Magnesium and Glucose Homeostasis

Total Page:16

File Type:pdf, Size:1020Kb

Magnesium and Glucose Homeostasis Diabetologia (1990) 33:511-514 Diabetologia Springer-Verlag 1990 Review Magnesium and glucose homeostasis G. Paolisso 1, A. Scheen 3, E D'Onofrio 2 and R Lef6bvre 3 Istituto di Gerontologia e Geriatria, 2 Istituto di Medicina Generale, Terapia Medica e Malattie del Metabolismo, University of Naples, Naples, Italy and 3 Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, University of Libge, Li6ge, Belgium Summary. Magnesium is an important ion in all living cells losses and insulin resistance. The extent to which such a low being a cofactor of many enzymes, especially those utilising intracellular magnesium content contributes to the develop- high energy phosphate bounds. The relationship between in- ment of macro- and microangiopathy remains to be estab- sulin and magnesium has been recently studied. In particular lished. A reduced intracellular magnesium content might it has been shown that magnesium plays the role of a second contribute to the impaired insulin response and action which messenger for insulin action; on the other hand, insulin itself occurs in Type 2 (non-insulin-dependent) diabetes mellitus. has been demonstrated to be an important regulatory factor Chronic magnesium supplementation can contribute to an of intracellular magnesium accumulation. Conditions associ- improvement in both islet Beta-cell response and insulin ac- ated with insulin resistance, such as hypertension or aging, tion in non-insulin-dependent diabetic subjects. are also associated with low intracellular magnesium con- tents. In diabetes mellitus, it is suggested that low intracellu- Key words: Magnesium, insulin, glucose homeostasis, lar magnesium levels result from both increased urinary diabetic complications, dietary magnesium supplements. Magnesium homeostasis In normal man, daily magnesium intake should be be- tween 240 and 480 mg to maintain an adequate magne- Magnesium is one of the most abundant ions present in liv- sium balance. No single factor appears to play a leading ing organisms. It is distributed in three major compart- role in the regulation of magnesium metabolism as does, ments of the body: about 65 % in the mineral phase of skele - for instance, vitamin D for calcium homeostasis [2]. Data ton, some 34% in the intracellular space and only 1% in the collected from measurements performed in a large series extracellular fluid [1]. The levels of magnesium in the plas- of animal species have shown that the small intestine is the ma of healthy people are remarkably constant, being on main site of magnesium absorption, but that the pattern of average 0.85 mmol/1 and varying less than 15% from this absorption varies with the species studied [5]. Most likely value [2]. The distribution of normal values for serum or there is a common mechanism for the transport of calcium plasma magnesiumis similarin men and women and almost and magnesium across the small intestinal wall [5], a the- one third is bound to plasma proteins. The remaining two- ory, however, that has been challenged [6]. Magnesium ex- thirds, which is diffusible or ionized, appears to be the bio- cretion is performed through renal pathways since an logically active component [2]. As reviewed by Flatman [3] amount equivalent to one third of the daily magnesium in- many cells keep their magnesium content well below elec- take is excreted through the kidney [2]. troch emical equilibrium, indicating that they possess an ac- Magnesium balance appears to be regulated by differ- tive magnesium transport system. This is also true for mito- ent hormones known to affect magnesium transport. chondria. The source of energy for magnesium transport Among them, calcitonin [7] and parathormone [8] have may be the coupling of magnesium exit to the obligatory long been thought to play a major role. Noradrenaline entry of either sodium (as in the nerve or muscle cells), and adrenaline appear to have different effects depend- protons (as in mitochondria) or potassium (a s in synapto- ing upon the tissue considered, since they stimulate mag- somes or pancreatic Beta-cells), which travel down their nesium uptake by fat cells while they reduce magnesium electrochemical gradients. In fact there is some evidence uptake by cardiac muscle cells [2]. Insulin has also been that a separate magnesium extrusion pump, driven by me- suggested as a regulatory hormone of the magnesium tabolic energy directly, does exist [4]. balance. In fact, Lostroh and Krahl [9, 10] were the first 512 G. Paolisso et al.: Magnesium and glucose homeostasis to demonstrate that insulin added in vitro promptly pro- Magnesium and insulin action motes a net increase in the accumulation of magnesium and potassium in uterine smooth muscle cells. These au- Numerous in vitro studies have pointed out the major role thors [9, 10] suggested that insulin, after interacting with of magnesium in insulin action [9, 10, 19, 20]. Lostroh and its own receptor on the plasma membrane, can affect an Krahl [9, 10] suggested magnesium as a second messenger ATPase pump increasing magnesium and potassium for insulin action. In fact, cellular magnesium deficiency is cellular entry. Recently reported data support an effect of correlated to an impaired function of many enzymes uti- insulin on magnesium transport. Indeed, during the lising high energy phosphate bonds, which are involved in course of an oral glucose tolerance test, a significant glucose metabolism, and require magnesium as a cofactor. decline in plasma magnesium with a contemporary signi- Furthermore, Tonyai et al. [20] have demonstrated that a ficant increase in erythrocyte magnesium levels does low erythrocyte magnesium content per se can increase occur [11]. Such opposite changes in plasma and erythro- membrane microviscosity and have suggested that this cyte magnesium levels are also seen during the course of mechanism may impair the interaction of insulin with its a euglycaemic hyperinsulinaemic glucose clamp [11]. Fi- receptor on the plasma membrane. nally, in vitro investigations have shown that erythrocytes In vivo, Moles and McMullen [21] have suggested that accumulate magnesium in the presence of glucose hypomagnesaemia may contribute to the insulin resis- (5 mmol/1) and insulin (100 mU/1), an effect entirely tance observed during the treatment of diabetic ketoaci- abolished by ouabain, while glucose alone had no signifi- dosis, while Durlach and Rayssiguer [22] reported that cant effect [11]. These in vivo and in vitro results thus chronic magnesium deficiency Contributes to reduce in- suggest that insulin is an important modulator of intracel- sulin sensitivity. lular magnesium content; furthermore, there are indi- Recent studies have also shown that aging and essen- cations that, as in other energy producing system, an tial hypertension, two classic conditions associated with ATPase-dependent pump is involved in the mechanisms insulin resistance [23-25], are also associated with an im- by which insulin regulates the erythrocyte magnesium paired insulin-mediated accumulation of magnesium into content [11]. erythrocytes. In essential hypertension [26], a significant reduction in plasma and erythrocyte magnesium levels and a reduced erythrocyte magnesium uptake response to incubation in the presence of insulin and high extracellu- Magnesium deficiency in man lar magnesium levels have been reported; these abnor- malities were associated with an increase in erythrocyte The existence of a state of magnesium deficiency has been membrane microviscosity. It was suggested that changes doubted for many years. However, severe hypomagne- in the physical state of the plasma membrane as well as in saemia is a well recognized clinical syndrome charac- insulin sensitivity were co-responsible for the lower ery- terized by: a)muscular symptoms (spasmophilia, gross throcyte magnesium level found in these patients. In aging muscular tremour, ataxia, tetany); b)psychic disorders [27], the reduced erythrocyte magnesium content was ex- (agitation, confusion and hallucinations); and, c) cardio- plained on the grounds of the well known insulin-resistant logical signs (low-voltage T-wave at the ECG). Labora- state frequently observed in this condition [23, 24]. The tory data (low serum magnesium levels associated with a extent to which changes in plasma membrane liquid com- normal serum calcium concentration and a normal blood position, which frequently occur and impair the interac- pH) confirm the diagnosis. As recently reviewed by Rein- tion of insulin with its receptor in the elderly [28], also con- hart [12], measurement of magnesium levels in the plasma tribute remains an open question. or serum is the usual method for determining magnesium homeostasis. However, it is well known that there may be a dissociation between serum and intracellular levels of Magnesium and diabetes mellitus magnesium [13, 14] and that intracellular levels may in- deed better reflect homeostasis. In this respect, erythro- In 1971, Londono and Rosenbloom [29] were the first to cytes or lymphocytes are frequently used while muscle demonstrate, in diabetic children, that a glucagon injec- biopsies or magnesium balance studies, although more tion induced a significant decline in plasma magnesium sensitive indices of magnesium deficiency, are rarely per- and calcium levels. Subsequently, Rosenbloom [30] ob- formed [12]. served that the decline in plasma magnesium and calcium Among all clinical conditions associated with a deple- levels observed during the course of an oral glucose toler-
Recommended publications
  • Magnesium Sulfate
    MAGNESIUM SULFATE Prepared at the 68th JECFA (2007), published in FAO JECFA Monographs 4 (2007), superseding the specifications prepared at the 63rd JECFA (2004) and published the Combined Compendium of Food Additive Specifications, FAO JECFA Monographs 1 (2005). An ADI “not specified” was established at the 68th JECFA (2007). SYNONYMS Epsom salt (heptahydrate); INS No.518 DEFINITION Magnesium sulfate occurs naturally in sea water, mineral springs and in minerals such as kieserite and epsomite. It is recovered from them or by reacting sulfuric acid and magnesium oxide. It is produced with one or seven molecules of water of hydration or in a dried form containing the equivalent of between 2 and 3 waters of hydration. Chemical names Magnesium sulfate C.A.S. number Monohydrate: 14168-73-1 Heptahydrate: 10034-99-8 Dried: 15244-36-7 Chemical formula Monohydrate: MgSO4.H2O Heptahydrate: MgSO4.7H2O Dried: MgSO4.xH2O, where x is the average hydration value (between 2 and 3) Formula weight Monohydrate: 138.38 Heptahydrate: 246.47 Assay Not less than 99.0 % and not more than 100.5% on the ignited basis DESCRIPTION Colourless crystals, granular crystalline powder or white powder. Crystals effloresce in warm, dry air. FUNCTIONAL USES Nutrient; flavour enhancer; firming agent; and processing aid (fermentation aid in the production of beer and malt beverages) CHARACTERISTICS IDENTIFICATION Solubility (Vol. 4) Freely soluble in water, very soluble in boiling water, and sparingly soluble in ethanol. Test for magnesium (Vol. 4) Passes test Test for sulfate (Vol. 4) Passes test PURITY Loss on ignition (Vol. 4) Monohydrate: between 13.0 and 16.0 %, Heptahydrate: between 40.0 and 52.0 %, Dried: between 22.0 and 32.0 % (105°, 2h, then 400° to constant weight) pH (Vol.
    [Show full text]
  • Mechanosynthesis of Magnesium and Calcium Salt?Urea Ionic Cocrystal
    Letter pubs.acs.org/journal/ascecg Mechanosynthesis of Magnesium and Calcium Salt−Urea Ionic Cocrystal Fertilizer Materials for Improved Nitrogen Management Kenneth Honer, Eren Kalfaoglu, Carlos Pico, Jane McCann, and Jonas Baltrusaitis* Department of Chemical and Biomolecular Engineering, Lehigh University, B336 Iacocca Hall, 111 Research Drive, Bethlehem, Pennsylvania 18015, United States *S Supporting Information ABSTRACT: Only 47% of the total fertilizer nitrogen applied to the environment is taken up by the plants whereas approximately 40% of the total fertilizer nitrogen lost to the environment reverts back into unreactive atmospheric dinitrogen that greatly affects the global nitrogen cycle including increased energy consumption for NH3 synthesis, as well as accumulation of nitrates in drinking water. In this letter, we provide a mechanochemical method of inorganic magnesium and calcium salt−urea ionic cocrystal synthesis to obtain enhanced stability nitrogen fertilizers. The solvent-free mechanochemical synthesis presented can result in a greater manufacturing process sustainability by reducing or eliminating the need for solution handling and evaporation. NH3 emission testing suggests that urea ionic cocrystals are capable of decreasing NH3 emissions to the environment when compared to pure urea, thus providing implications for a sustainable global solution to the management of the nitrogen cycle. KEYWORDS: Fertilizers, Nitrogen, urea, Mechanochemistry, Cocrystal, pXRD, NH3 Emissions, Stability ■ INTRODUCTION ammonia as opposed to up to 61.1% of soil treated with urea 7,8 fi only, which suggests that major improvements to the global Atmospheric dinitrogen, N2, xation to synthesize ammonia, 9,10 ’ 1 nitrogen cycle are achievable. Additionally, urea molecular NH3, consumes more than 1% of the world s primary energy.
    [Show full text]
  • The Importance of Minerals in the Long Term Health of Humans Philip H
    The Importance of Minerals in the Long Term Health of Humans Philip H. Merrell, PhD Technical Market Manager, Jost Chemical Co. Calcium 20 Ca 40.078 Copper 29 Cu 63.546 Iron Magnesium 26 12 Fe Mg 55.845 24.305 Manganese Zinc 25 30 Mn Zn 55.938 65.380 Table of Contents Introduction, Discussion and General Information ..................................1 Calcium ......................................................................................................3 Copper .......................................................................................................7 Iron ...........................................................................................................10 Magnesium ..............................................................................................13 Manganese ..............................................................................................16 Zinc ..........................................................................................................19 Introduction Daily intakes of several minerals are necessary for the continued basic functioning of the human body. The minerals, Calcium (Ca), Iron (Fe), Copper (Cu), Magnesium (Mg), Manganese (Mn), and Zinc (Zn) are known to be necessary for proper function and growth of the many systems in the human body and thus contribute to the overall health of the individual. There are several other trace minerals requirements. Minimum (and in some cases maximum) daily amounts for each of these minerals have been established by the Institute of
    [Show full text]
  • Sulfate Resistance Study of Carbonated Low-Calcium Silicate Systems
    Sixth International Conference on Durability of Concrete Structures Paper Number PSE12 18 - 20 July 2018 University of Leeds, Leeds, West Yorkshire, LS2 9JT, United Kingdom Sulfate Resistance Study of Carbonated Low-Calcium Silicate Systems R. Tokpatayeva and J. Olek Lyles School of Civil Engineering, Purdue University, West Lafayette, IN, USA J. Jain, A. Seth and N. DeCristofaro Solidia Technologies Inc., Piscataway, NJ, USA ABSTRACT This paper summarizes the results of sulfate resistance study of carbonated mortar specimens made with Solidia Cement (SC) and tested for expansion according to ASTM C1012 specification while exposed to three types of soak solutions: sodium sulfate, magnesium sulfate and deionized water. A control set of ordinary portland cement (OPC) mortars was also evaluated. Besides the length change measurements, visual observations of changes in the appearance of specimens were conducted after various lengths of exposure. In addition, microstructural characterization of the specimens was conducted using scanning electron microscopy (SEM), X-ray diffraction (XRD) and thermo-gravimetric analysis (TGA) techniques. Finally, changes in the concentration of the chemical species present in the soak solutions in contact with the SC specimens were evaluated using both, the ion chromatography (IC) and the inductively coupled plasma optical emission spectrometry (ICP-OES). As expected, the OPC mortar specimens started deteriorating early and reached the critical (i.e.0.1%) level of expansion in about 4 months in case of sodium sulfate solution and in about 6 months in case of magnesium sulfate solution. With respect to the SC mortar specimens, those exposed to magnesium sulfate solution showed higher expansion than those exposed to sodium sulfate solution.
    [Show full text]
  • Managing Ferret Toxicoses J
    CLINICIAN’S NOTEBOOK Managing Ferret Toxicoses J. RICHARDSON AND R. BALABUSZKO Jill A. Richardson, DVM, Dipl ACFE ASPCA National Animal Poison Control Center 1717 South Philo Road Suite 36 Urbana, Illinois 61802 [email protected] FERRETS ARE EXTREMELY CURIOUS and adept at accessing areas where PRACTICE TIP baits, cleaners, chemicals and medica- Rachel A. Balabuszko, CVT tions are stored. Ferrets can even pry ASPCA National Animal Poison caps from child-resistant bottles or Control Center chew through heavy plastic contain- ers. Products such as antifreeze, Dr. Jill A. Richardson received her DVM flavored medications or pest control degree from Tuskegee University in baits have an appealing taste. Because 1994. In 1996, following experience in the average weight of the adult ferret small animal practices in Tennessee and is less than 2 kg, even small amounts in West Virginia, Dr. Richardson joined of toxins can be dangerous when the ASPCA National Animal Poison ingested. Therefore, prompt treatment Control Center as a Veterinary Poison of toxicoses is essential. Information Specialist. Rachel Balabuszko, CVT, joined the In cases of oral exposure, ferrets have ASPCA National Animal Poison Control the ability to vomit. However, the Center as a Certified Veterinary length of time since ingestion of the Ferrets can be restrained by scruffing Technician in 1998, after receiving her toxicant, the ferret’s age, its previous the loose skin on the back of the neck. associate degree in veterinary technol- medical history, and the type of ogy from Parkland College. poison ingested all affect the decision to induce emesis. Tom Schaefges Photography Sidney, Illinois [email protected] EXOTIC DVM VOLUME 2.4 2000 23 CLINICIAN’S NOTEBOOK STEPS IN MANAGING FERRET TOXICOSES START ASSESS THE SITUATION STABILIZE THE FERRET ✖ Is the ferret seizuring? ✖ Administer oxygen if necessary ✖ Is the ferret breathing? ✖ Control seizures ✖ What is the heart rate? ✖ Correct any cardiovascular ✖ What color are the mucous abnormality membranes? Table 1.
    [Show full text]
  • Magnesium Sulfate for Neuroprotection Practice Guideline
    [Type text] [Type text] Updated June 2013 Magnesium Sulfate for Neuroprotection Practice Guideline I. Background: Magnesium sulfate has been suggested to have neuro-protective effect in retrospective studies from 1987 and 1996. Since that time three randomized control trials have been performed to assess magnesium therapy for fetal neuroprotection. These studies have failed to demonstrate statistically significant decrease in combined outcome of cerebral palsy and death or improved overall neonatal survival. However, these results did demonstrate a significant decrease in cerebral palsy of any severity by 30%, particularly moderate-severe cerebral palsy (40-45%). The number needed to treat at less than 32 weeks gestation is 56. The presumptive mechanism of action for magnesium sulfate focuses on the N-methyl-D-aspartate receptor. Additional magnesium effects include calcium channel blockade resulting in cerebrovascular relaxation and magnesium mediated decreases in free radical production and reductions in the production of inflammatory cytokines. Magnesium sulfate should not be used as a tocolytic simply because of the potential for neuro-protective effects. In a recent committee opinion, ACOG states “the available evidence suggests that magnesium sulfate given before anticipated early preterm birth reduces the risk of cerebral palsy in surviving infants” but specific guidelines should be established. “The U.S. FDA has recently changed the classification of magnesium sulfate injection from Category A to Category D. However, this change was based on a small number of neonatal outcomes in cases in which the average duration of exposure was 9.6 weeks. The ACOG Committee on Obstetric Practice and the Society for Maternal-Fetal Medicine continue to support the use of magnesium sulfate in obstetric care for appropriate conditions and for appropriate, short term (usually less than 48 hours) durations of treatment.” II.
    [Show full text]
  • Disposal of Solid Chemicals in the Normal Trash
    Disposal of Solid Chemicals in the Normal Trash Many solid chemicals can be safety discarded into the normal trash, provided they are in containers that are not broken or cracked and have tightly fitting caps. These chemicals are considered acceptable for ordinary disposal because they display none of the properties of hazardous waste, are of low acute toxicity, and have not been identified as having any chronic toxic effects as summarized in the National Institute of Occupational Safety and Health (NIOSH) “Registry of Toxic Effects of Chemical Substances”. Examples of chemicals acceptable for disposal as regular trash are listed below. To dispose of these chemicals, place the containers in a box lined with a plastic bag, tape the top of the box shut, write “Normal Trash” on the box and then place the box next to the lab trash container. Only solid forms of these chemicals can be disposed in this manner. Any questions about these chemicals or other chemicals that may be disposed of in the normal trash should be directed to the Hazardous Materials Technician (610) 330-5225. Chemicals Generally Acceptable for Disposal as Regular Trash Acacia powder, gum Detergent (most) Methyl salicylate Sodium carbonate arabic Cation exchange resins Methylene blue Sodium chloride Acid, Ascorbic Chromatographic Methyl stearate Sodium citrate Acid, Benzoic absorbents Nutrient agar Sodium dodecyl sulfate Acid, Boric Crystal violet Octacosane (SDS) Acid, Casamind Dextrin Parafin Sodium formate Acid, Citric Dextrose Pepsin Sodium iodide Acid, Lactic Diatomaceous
    [Show full text]
  • Magnesium Sulfate
    MODULE III MAGNESIUM SULFATE Manual for Procurement & Supply of Quality-Assured MNCH Commodities MAGNESIUM SULFATE INJECTION, 500 MG/ML IN 2-ML AND 10-ML AMPOULE GENERAL PRODUCT INFORMATION Pre-eclampsia and eclampsia is the second-leading cause of maternal death in low- and middle-income countries. It is most often detected through the elevation of blood pressure during pregnancy, which can be followed by seizures, kidney and liver damage, and maternal and fetal death, if untreated. Magnesium sulfate is recognized by WHO as the safest, most effective, and lowest-cost medicine for treating pre-eclampsia and eclampsia. It is also considered an essential medicine by the UN Commission on Life-Saving Commodities for Women and Children. Other anticonvulsant medicines, such as diazepam and phenytoin, are less effective and riskier. Magnesium sulfate should be the sole first-line treatment of pre-eclampsia and eclampsia that should be procured over other anticonvulsants and made available in all health facilities to help lower maternal death rates and improve overall maternal health. MSꟷ1 | Manual for Procurement & Supply of Quality-Assured MNCH Commodities Magnesium Sulfate KEY CONSIDERATIONS IN PROCUREMENT Procurement should be made from trusted sources. This includes manufacturers prequalified by WHO or approved by a SRA for magnesium sulfate injection and 1. those with a proven record of quality products. Procurers need to focus on product quality to ensure that it is sterile and safe for patient use as magnesium sulfate is an injectable medicine. 2. KEY QUALITY CONSIDERATIONS Product specification Products that are procured must comply with pharmacopoeial specifications, such as those of the International Pharmacopoeia, US Pharmacopoeia, and British Pharmacopoeia, as detailed in the “Supply” section 4 below.
    [Show full text]
  • Plant Health Solutions
    Plant Health Solutions NUTRITION PORTFOLIO ■ Foliar Nutrients ■ Chelated Nutrients ■ Complexed Nutrients ■ Nutrient Efficiency Enhancers ■ Botanical Blends ■ Humic Acids About BRANDT ® BRANDT is a privately owned U.S. manufacturer and leading supplier of specialty inputs for the agriculture, turf, ornamental, and lawn and garden markets. BRANDT has one of the largest portfolios of micronutrients and OMRI Listed products available today. Its products are used on some of the world’s most notable farms, vineyards and orchards. Contact Us 800 300 6559 [email protected] Visit us online at: www.BRANDT.co 2 Contents Foliar Nutrients . 4 Chelated Nutrients . 8 Complexed Nutrients . 10 Nutrient Efficiency Enhancers. 14 Botanical Blends. 17 Humic Acid Soil Amendments . 18 Not all products are registered for sale in every country and all 50 U.S. states. Please check label for use and contact your BRANDT representative with any questions. 3 Foliar Nutrients BRANDT Smart System BRANDT Manni-Plex 4 BRANDT Smart System® Advanced Compatibility Foliar Nutrition Smarter Foliar Nutrient Delivery BRANDT Smart System foliar nutrients were designed for use in tank mix environments where compatibility concerns may have previously been a challenge. The proprietary formulations provide supplemental secondary and micronutrients to plant growing points quickly and effectively, and may be used in a wide range of tank mix solutions. BRANDT Smart System is an excellent option for in-season nutrient enhancement and replenishment and optimal plant health. Key Advantages
    [Show full text]
  • Calcium Carbonate Dissolution and Precipitation in Water: Factors Affecting the Carbonate Saturometer Method
    Utah State University DigitalCommons@USU All Graduate Theses and Dissertations Graduate Studies 5-1971 Calcium Carbonate Dissolution and Precipitation in Water: Factors Affecting the Carbonate Saturometer Method Lyle M. Dabb Utah State University Follow this and additional works at: https://digitalcommons.usu.edu/etd Part of the Chemistry Commons, and the Soil Science Commons Recommended Citation Dabb, Lyle M., "Calcium Carbonate Dissolution and Precipitation in Water: Factors Affecting the Carbonate Saturometer Method" (1971). All Graduate Theses and Dissertations. 2991. https://digitalcommons.usu.edu/etd/2991 This Thesis is brought to you for free and open access by the Graduate Studies at DigitalCommons@USU. It has been accepted for inclusion in All Graduate Theses and Dissertations by an authorized administrator of DigitalCommons@USU. For more information, please contact [email protected]. ACKNOWLEDGMENTS I would like to thank Dr. Jerome J . Jurinak for his patience and guidance during my classwork and lab experiments. I would also like t o thank Dr . R. L . Smith and Dr. H. B. Petersen for serving as committee members. I thank Robert A. Griffin and Dr. Sung-Ho Lai for their friendship, help, and encouragement. I thank Dr. John J. Hassett for his help when I started this research. Pa rtial support of this study by the Federal Water Quality Admin- istration is gr atefully acknowledged. I thank my wife, Sandy, for keeping our horne affairs running so smoothly and for her understanding and patience. ¥ m fJJt- Lyle M. Dabb TABLE OF CONTENTS Page INTRODUCTION 1 REVIEW OF LITERATURE 3 METHODS AND MATERIALS RESULTS AND DISCUSSION 10 EIGHT NATURAL WATERS FROM VERNAL, UTAH 31 SUMMARY AND CONCLUSIONS .
    [Show full text]
  • Solid Chemicals for the Normal Trash
    SOLID CHEMICALS FOR THE NORMAL TRASH Solid chemicals acceptable for disposal as regular trash are listed below: Acacia powder, gum arabic Calcium silicate Manganese sulfate Acid, Ascorbic Calcium sulfate Methyl red Acid, Benzoic Detergent (most) Methyl salicylate Acid, Boric Cation exchange resins Methylene blue Acid, Casamind Crystal violet Methyl stearate Acid, Citric Dextrin Nutrient agar Acid, Lactic Dextrose Octacosane Acid, Oleic Diatomaceous earth Parafin Acid, Phthalic Docosanoic acid Pepsin Acid, Salicycle Drierite (calcium sulfate, anhydrous) Peptone Acid, Silicic Ferric oxide Petroleum jelly Acid, Stearic Ferric phosphate Polyethylene, solid Acid, Succinic Ferric pyrophosphate Polystryene Acid, Tartaric Ferric sulfate Potassium acetate Acrylamide gels Ferrous ammonium sulfate Potassium bicarbonate Agar(s) Galactose Potassium bromide Albumen Geletin Potassium carbonate Alumina Gum arabic Potassium chloride Aluminum oxide Gum guaiac Potassium citrate Amino acids, naturally occurring Hexadecanol, 1- Potassium ferricyanide Ammonium bicarbonate Kaolin Potassium iodide Ammonium phosphate Lactose Potassium phosphate Ammonium sulfate Lanolin Potassium sodium tartrate Ammonium sulfamate Lauric acid Potassium sulfate Base, blood agar Lauryl sulfate Potassium sulfite Beef extract Lithium carbonate Potassium sulfocyanate Behenic acid Lithium chloride Pumice Bentonite Lithium sulfate Salts, naturally occurring Brain heart infusion Litmus Sand Bromphenol blue Magnesium carbonate Silica Broth, nutrient Magnesium chloride Silica gel, unused
    [Show full text]
  • Magnesium Sulfate in 5% Dextrose Injection, Usp
    MAGNESIUM SULFATE IN 5% DEXTROSE INJECTION, USP Flexible Plastic Container For Intravenous Use Only Rx only DESCRIPTION Magnesium Sulfate in 5% Dextrose Injection, USP is a sterile, nonpyrogenic solution of magnesium sulfate heptahydrate and dextrose in water for injection. Each 100 mL contains 1 or 2 g magnesium sulfate heptahydrate and dextrose, hydrous 5 g in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. The pH is 4.5 (3.5 to 6.5). It is available in 1% and 2% concentrations. See HOW SUPPLIED section for the content and characteristics of available dosage forms and sizes. Magnesium Sulfate, USP heptahydrate is chemically designated MgSO4 • 7H2O, colorless crystals or white powder freely soluble in water. Dextrose, USP is chemically designated D-glucose, monohydrate (C6H12O6 • H2O), a hexose sugar freely soluble in water. It has the following structural formula: Molecular weight 198.17. Water for Injection, USP is chemically designated H2O. The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly. Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials. Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.
    [Show full text]