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Kiionize Geparunant Charges; Dr
'V'V, 1*. v if MONDAY, MARCH 21, 194t gpgtttng ijeraUi The Weather Average Dally N at’Fraaa Run FuraaaiM at U. 8. Haathar Buiaus Wm lb s Mm Ui oI Fabmuy. Ift* ahip o f J e m la that H glvoa man morning ineludod tho- nnthema f f,ip*thiwg to live op to,” Bav. Bfl- “Ood So Loved the Wortd" by Cloudy and vary warm this aft- Mrs. Major BlaseU of Stresses Need arannn; eccasloaal rala tonight, wlU be the special "P^okm *t ^ To Be Director gar continnad. * Moore and *T^rd Moat Holy” by 9,713 amllng Wadnrwlay mornlag aad 'jlljboulTo^ Friendship Circle of the Salvation m w maponalMlity la oura. Th to Roaaini sung by the South Ckurch Btambar o l «ko ^ n iM fnliowad by clrariai. Arm y tonight at 7:30 p.m. love thht Jeaua glvea to othom choir and the organ prelude "Ada For Friendship mfleets through their Uvea. Jeaua Baraaa a< OrmdaMaoa ^ ^T M n to a POMlbUtty that tht gio” (SonaU No. 8) by Haydn Manchester-^4 City of Village Charm "Tredowata,” a Polish movie, still glvea ua thla challenge today and the poatlude “Cantablle” (So ilfi^ m eompattUra to Uvo.up to the bbat that U In ua. iM n S tha aaoetln# ot WlU be shown this Sunday after naU No. 8) by Haydn played by noon at 3 o’clock In W hlU B ^ le Rev.’Edgar Preaches the Chapter, Order o( DeMo- "Jeaua aleo gave people aotne- Oeorge G.* Ashton, organist ot the AivtrM M ag an Fags 18) MANiCHESTER, CONN., TUESDAY, MARCH 22,1949 (FULItlELN FACES) FUICE FOUR CENTS ■-f^ tly. -
A Computational Approach for Defining a Signature of Β-Cell Golgi Stress in Diabetes Mellitus
Page 1 of 781 Diabetes A Computational Approach for Defining a Signature of β-Cell Golgi Stress in Diabetes Mellitus Robert N. Bone1,6,7, Olufunmilola Oyebamiji2, Sayali Talware2, Sharmila Selvaraj2, Preethi Krishnan3,6, Farooq Syed1,6,7, Huanmei Wu2, Carmella Evans-Molina 1,3,4,5,6,7,8* Departments of 1Pediatrics, 3Medicine, 4Anatomy, Cell Biology & Physiology, 5Biochemistry & Molecular Biology, the 6Center for Diabetes & Metabolic Diseases, and the 7Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202; 2Department of BioHealth Informatics, Indiana University-Purdue University Indianapolis, Indianapolis, IN, 46202; 8Roudebush VA Medical Center, Indianapolis, IN 46202. *Corresponding Author(s): Carmella Evans-Molina, MD, PhD ([email protected]) Indiana University School of Medicine, 635 Barnhill Drive, MS 2031A, Indianapolis, IN 46202, Telephone: (317) 274-4145, Fax (317) 274-4107 Running Title: Golgi Stress Response in Diabetes Word Count: 4358 Number of Figures: 6 Keywords: Golgi apparatus stress, Islets, β cell, Type 1 diabetes, Type 2 diabetes 1 Diabetes Publish Ahead of Print, published online August 20, 2020 Diabetes Page 2 of 781 ABSTRACT The Golgi apparatus (GA) is an important site of insulin processing and granule maturation, but whether GA organelle dysfunction and GA stress are present in the diabetic β-cell has not been tested. We utilized an informatics-based approach to develop a transcriptional signature of β-cell GA stress using existing RNA sequencing and microarray datasets generated using human islets from donors with diabetes and islets where type 1(T1D) and type 2 diabetes (T2D) had been modeled ex vivo. To narrow our results to GA-specific genes, we applied a filter set of 1,030 genes accepted as GA associated. -
1946-03-15 [P
^ l» I NHHS Meets Calvin Morning Watch' Coolidge_ High__■ Today WITH DURHAM m Browns Will Have A The Pennant Pie Edward Sachs TO GET U M Finger Jn Fifth of a series from major' of 60 hits, a naverage of 15 pel over to third base. His .277 bat- or 12 that Sewell expects to awry when it Wonder league training camps. nine innings. They hoisted the ting mark of last season is far too into the campaign opans. ^^timesWe By CHESTER L. SMITH storm warnings then and there for valuable to be parked on the Lucadello and Leu March 14.—Sometimes we Interstate Play Includes Johnny DURHAM, wish that we had NEA Special Correspondent their rivals. bench, and in some respects he is Schulte have the inside track M s advice and — our father gone into March 14. Sewell’s this even a a followed the undertaking Kentucky, D. C., Vir- ANAHEIM, Cal., starting pitchers better hitter in pinch reserve infielders. He used to say that there was (NEA). — The St. Louis Browns year will be Galehouse, A1 than with men business. something peaceful Denny Stephens, especially There is an ironic twist to tht about ginia Aggregations probably aren’t going to win the Hollingsworth, Jack Kramer, Bob on bases. soul-sopthing Working with dead “No Shir- situation the Browns find them- and people pennant in the American League Muncrief, Nels Potter, Alvis hot corner isn’t he would March However, the selves in this year. They are • no fuss,” comment. “And no back DURHAM, 14.—(IF)—The this year, but have a ley and Steve Sundra. -
Ainst Seek Fleet Location Going on While
HATUICDAT, AUGXJIT 11, IM S . The Weather t A G B TWELVE Manchester Evening Herald ATfitago Dsily OrfiulathMi Fe'sseasff of U. S. Weathsr Bamno For Iba Moatb of 4alr> privileges by carving Initials on fusion that comes from having the little devila and hee'd attentloa at Partly doody toniglit aad Tues th^^setteesj and ,on pne bench at other three classes in. school when hopie. -'Not once, haa the' group WS JtZPBBSKNT THE STRONGBST 8 ,8 9 0 day; widsly scattered thuader- they are trying tb 16am their way been reprimanded for thslr actlona showers Trisaday afternoon; eoo- About Town le i^ .a portion of the wood had Member of the Audit itaaed sram and bamM. Heard 4 long Main Street lloen pried oft. Near anotb.prwas about. this season to our knowledge. The HtOCK AND DIYnMOOi ^a halfplat bt;own' whiskey bottle "I undqratand that thla is done youngsters will continue to "nlae Bureau of ClrculatloBa in some outer High schobls and. I the devir until sotnethjag is donp.' PATDNI hester— A City o f ViUage Charm bapt Jamea Hamilton, of P7 And on Some of Mvncliester’s Side Streets, Too and at another bench the broken aisO'understand tha^ some colleges Oardon atreet. wh<Tla a veteran of _____ • • _____.__L heck of a similar bottle, .g joefiace Tiays pre-Freshmatv'days jqat for O O M PA N m X" both World War 1 and World War to the playing children Who may the same purpose. ... Tom Dannaber, prominent Dem m Faie M) MANCHESTER, CONN., MONDAY,. -
National Pastime a REVIEW of BASEBALL HISTORY
THE National Pastime A REVIEW OF BASEBALL HISTORY CONTENTS The Chicago Cubs' College of Coaches Richard J. Puerzer ................. 3 Dizzy Dean, Brownie for a Day Ronnie Joyner. .................. .. 18 The '62 Mets Keith Olbermann ................ .. 23 Professional Baseball and Football Brian McKenna. ................ •.. 26 Wallace Goldsmith, Sports Cartoonist '.' . Ed Brackett ..................... .. 33 About the Boston Pilgrims Bill Nowlin. ..................... .. 40 Danny Gardella and the Reserve Clause David Mandell, ,................. .. 41 Bringing Home the Bacon Jacob Pomrenke ................. .. 45 "Why, They'll Bet on a Foul Ball" Warren Corbett. ................. .. 54 Clemente's Entry into Organized Baseball Stew Thornley. ................. 61 The Winning Team Rob Edelman. ................... .. 72 Fascinating Aspects About Detroit Tiger Uniform Numbers Herm Krabbenhoft. .............. .. 77 Crossing Red River: Spring Training in Texas Frank Jackson ................... .. 85 The Windowbreakers: The 1947 Giants Steve Treder. .................... .. 92 Marathon Men: Rube and Cy Go the Distance Dan O'Brien .................... .. 95 I'm a Faster Man Than You Are, Heinie Zim Richard A. Smiley. ............... .. 97 Twilight at Ebbets Field Rory Costello 104 Was Roy Cullenbine a Better Batter than Joe DiMaggio? Walter Dunn Tucker 110 The 1945 All-Star Game Bill Nowlin 111 The First Unknown Soldier Bob Bailey 115 This Is Your Sport on Cocaine Steve Beitler 119 Sound BITES Darryl Brock 123 Death in the Ohio State League Craig -
Crisp Celery*2»2S'
16 -THURSDAY—rrBRUARY 15, 1945 MONITOR-LEADER MOUNT CLEMENS. MICH. H. A. SMITH WAREHOUSE MARKET Marriage Honor Students Denies Laxity Licenses in Sending Son Arthur F. Rolph, 34. 8412 Are Revealed to Classes Gardenia, tenter Line, Bernice alleged- M. Backcnstose, 19, Romeo, fil* Utica Pupils ROSEVILLE—For his 12-year- e ’ teb. 5. ly failing to send Wins Honors school regu- Anthony Dissinger, 41. 20805 old son Donald to larly Sept. 1944, 'lversal, East Detroit, and A Honor Roll since 15, UTICA—The Shelby Townsend, 43, of len Ann Martin, 29, 20314 for the high school includes Mar- Ballanger, was ar- Detroit, filed Feb 2. garet Heinecke, Roland Schus- 26220 raigned in Justice Court be- W. Shaw. 25, 8292 ter, and Donna Turner, ninth Fancy California Clyde fore Judge Frank E. Jean- TEXAS Dodge, Dyke, and Constance grade; Doris Baumgartner, 10th Van nette on Tuesday afternoon SEEDLESS SEEDLESS NAVEL Juntti, 18, 8211 Maxwell, Van grade; Norma us, Mary K 1 a on complaint of the school's Dyke, filed Feb. 5. Walsh, 11th; Elsie Heinecke. Doris Rahn, Henry Scheper and truant officer. Townsend George Raschid, 30. Grosse re- Marilyn Ollsen, 12th grade. pleaded innocent and was ORANGES Pointe Park, and Mary Sofie. GRAPEFRUIT leased on personal bond, Baltimore, 5 The Honor Rail full fol- Sove 20. New filed Feb. in pending his trial, set for Feb. 25. 130 Gallup lows: Grade 8: Nancy Jen Criss- Elton O. Jobse. 23, at 10 a.m. H. A. Smith Fruits ond Vegetobles or# tho finest on tho market. Our «>*• avenue. Mt. Clemens, and Lil- man. -
F All Four Flag Rivals in a L Hunt Desperately for Pitcher
I fbettittg JMaf ^pfljs * f All Four D. Rivals in A L Washington, C., Tuesday, August 29, 1944—A—10 Flag Hunt Desperately for Pitcher Outcome of Lose or Draw Struggle Twin Bills Impose Big Burden Win, to By JOHN LARDNER. Likely Depend On Griffs' Slim Slab Corps Br JOHN B. KELLER, Ihurlers available until Saturday and Nelson 'Greatest' Golfer Stirs Star Staff Correspondent Rating Jones Fans On New Talent thent the only addition to the staff Out in Spokane, Wash., where the PGA golf tournament ended PHILADELPHIA, Pa., Aug. 29— will be the none too capable Bill BY with a bombshell effect when Byron Nelson was beaten in the final JACK HAND, A twilight-night double-header with Zinser,; a week-end performer. Associated Press Sports by an obscure pro from Evansville, Ind., name of Bob Hamilton, some Writer. Philadelphia's Athletics tonight So with another double-header World of the historians covering the match gave the surprise an extra Series talk was legitinmte opens the busiest six days of the duei Thursday in New York against business in four coat of paint by referring to Nelson as the top golfer of all time. American League American League season for the lthe Yankees and a third one sched- Specifically, I noticed one line of prose which said: “In fact, clubhouses today after a routine Nats. Before returning to Wash- uledi for Sunday against the same Nelson is considered one of the greatest, if not the best, the game has postseason planning session in Com- ington for a Labor Day twin bill club,< the Washington skipper will known." missioner K. -
Yank Terry, Red Sox Rookie,Hurls 3 -Hitter to Hand Yankees Their First Defeat, 5- 7
Yank Terry, Red Sox Rookie,Hurls 3 -Hitter to Hand Yankees Their First Defeat, 5- 7 ----- -.. A-— -------- Victory Lands Boston Probable Pitchers Phils' First Triumph Sons of Repulse Gain In Majors Today In Tie Br the Associated Press. Comes as Homers Three-Way • Two Victories NEW YORK. April II -Prob- Big able pitchers tn the major league* For First Place tomorrow: 2-1 American League. Nip Brooks, In Potomac Hunt Detroit at St Louis (2)—Ben- Coast League's '41 Ace ton and Fuchs vs. Niggeiing and Score With One Pilot Auker Champs Captures Exnicios When Misses Shutout Washington at Philadelphia <2> Hit Before Marthey, And Recall Triumphs Pinch Hitter Walks —Hudson and Newsome vs. Mar- chlldon and Harris. Etten Get Drives In Master's Plate Chicago at Cleveland—Rigney S) the Associated mu. By th» A«oct»t«J Pr«M. vs A1 Smith. By l.ARKY LAWRENCE. NEW YORK April 18 —The World BROOKLYN. 18 —The Phil- Boston at New York—H. New- April Two sons of the New York Yankees met great Repulse, Champion some vs Bruer adelphia Phil*, loser* of their first their match In Rookie Yank sire of celebrated hunter* and today National League. four National League games, finally Terry, who limited them to three as won the feature and an- St Louis at Pittsburgh—Beas- found the victory road today Jumpers, hit* in pitching the Boston Red out a 3-1 decision ley vs. Diet*. they squeesed other important event at the Po- Box to a 5-1 decision. New York »t Boston—Hubbell over the champion Brooklyn Dodg- In the their tomac Hunt's hunter trial* yester- handlnf champions vs Tobin. -
Supplementary Table S1. PCR Primer and Probe Set Information
Supplementary Table S1. PCR primer and probe set information NCBI Entrez Gene TaqMan Gene Expression Gene Name Gene ID* Symbol Assay ID 59085 Asl argininosuccinate lyase Rn01480437_g1 25698 Ass1 argininosuccinate synthase 1 Rn00565808_g1 292804 Gpi glucose-6-phosphate isomerase Rn01475756_m1 25104 Pc pyruvate carboxylase Rn00562534_m1 361596 Idh2 isocitrate dehydrogenase 2 Rn01478119_m1 81718 Cdo1 cysteine dioxygenasetype 1 Rn00583853_m1 25256 Fmo1 flavin containing monooxygenase 1 Rn00562945_m1 246248 Fmo5 flavin containing monooxygenase 5 Rn00595199_m1 81822 Actb β-actin Rn00667869_m1 *Gene IDs reference The National Center for Biotechnology Information database 1 Supplementary Table S2. Metabolite assignments and H NMR data in urine samples of rat* Urine Metabolite δ1H (ppm) 1 N-Methylnicotinamide 4.48(s) 8.18(t) 8.90(d) 8.97(d) 2 Nicotinamide N-oxide 7.73(dd) 8.12(m) 8.48(m) 3 Formate 8.46(s) 4 Hippurate 3.97(d) 7.55(t) 7.64(m) 7.84(dd) 8.56(s) 5 Tryptophan 3.30(dd) 3.47(dd) 4.05(dd) 7.20(m) 7.28(m) 7.50(d) 7.71(d) 6 Phenylalanine 3.11(dd) 3.28(dd) 3.99(dd) 7.36(m) 7.42(m) 7 Tyrosine 3.04(dd) 3.19(dd) 3.93(dd) 6.89(m) 7.17(m) 8 Fumarate 6.53(s) 9 Allantoin 5.39(s) 6.05(s) 7.26(s) 8.01(s) 10 Urea 5.80(s) 11 Glucose 3.24(dd) 3.39(t) 3.40(t) 3.45(m) 3.48(t) 3.53(dd) 3.70(t) 3.72(dd) 3.76(dd) 3.82(m) 3.84(dd) 3.89(dd) 4.65(d) 5.24(d) 12 Tartrate 4.36(s) 13 Threonine 1.33(d) 3.58(d) 4.24(m) 14 Creatinine 3.05(s) 4.06(s) 15 Creatine 3.02(s) 3.95(s) 16 Glycine 3.57(s) 17 Taurine 3.27(t) 3.43(t) 18 Choline 3.20(s) 3.51(m) 4.06(m) 19 cis-Aconitate -
July 26, 1944 Volume Xijv Number 255
aATJON OAL&MDAa l'Il~.:J) I'OOUS blue .tampa AI IhroUilh ZlI aud AS. Douk I valid IDdefllllt~y; MEAT Nd ItamPl AI Ibrouch ZI. book • Rain nlkI IDdtflnlleQI. SUCAR stamp 30. 31. U. IIqok • valJd lncIefl nI\oQ"; stamp 40 for annina • ..,., uplns )'ab. 18,. 1"5; SHOll Itamp, alrpw.. starnp 1 and :l bQOlt 3 v.Ud 7:E; OASO- DAILY IOWAN IOWA: Scattered Sbawera Lll'il: A-U coupon V1>Jld throu,h Sept. 21. lett; OIL ~rlOd THE .. 5, valid throllgh Sept. 30. 11144 ; period 1 voll4 Aba. 31, ,~ Iowa City/s Morning Newspaper t1V£ CENTS ..... AUOOIAT.., ..... IOWA CITY, IOWA WEDNESDAY, JULY 26, 1944 VOLUME XIJV NUMBER 255 Re d Armles . Ta k. e St an d J~nctiononEaslernYank Forces Effecf All-les 0 pen Coor d- Ina t ed . Seven Miles From Vistula Sl~::!~::~r Off - - . " " • I ' 443 Americans Killed ens Ive Normandy. Ihe Conquering Soviets At a Glane.- Hitler Gives Goering, In Guam Invasion ------------'-------------_ _ ______.,.- _-J' • . m, e in Ihrealen 10 Outflank Todoy' s GOebbels Increased Q~":;'::"~~'.~=~~~ 1,500 Allied Bombers WOUNDED NAZI GIVEN BOOST American Doughboys Warsaw, Drive West Power Over Germans I G~a~S~~~ti~ini!~i ~:la~~s, i~'::pd~ Hit 10-Square Miles Stage Heavy Assault Japan's innel' defense arc, with 0 Reuters Dispatch Says Iowan 'Big Four' of Nazism IAmerican forces effecting u junc- nNormandy Front In Sf. Lo Section Russian Frontal Drive * * * C nd d R II lion on Ihe eastern shOres ot ____ omma e to a Y Guam's strategic ApI'S harbor, Arrives at Vistula Allied al'JllJes In Normandy open All Existing Strength were unnounced yesterday by RAF Batters Nazis British Troops Face w d 1 AP greatest coordinated offensive of Adm. -
The American Legion Magazine [Volume 104, No. 6 (June 1978)]
! This year you have to try Haband's YOU WILL BE SHOCKED AT THIS VALUE.' but you can SEE FOR YOURSELF At No Risk! Who ever heard of buying a suit by mail? Literally hundreds of thousands of men today! Because Haband, the mail order people from Paterson, N.J., are fast becoming the Suit Capitol of America with this one ultra perfect, very dressy summer suit! Look, in local stores a seersucker suit can run you $90, $160, or $185! Yet here is a deluxe 100% polyester doubleknit No-Wrinkle Seersucker, in your exact size, delivered all ready to wear for only $39.95 ! Don't Let the Low Price Fool You / This is a beautiful fabric, soft and supple to touch, that moves easily with every turn of your body. You get excellent matching of patterns. Exact fit. And meticulous attention to tailoring details, like sharp clean lapels, full lining, and wool felt undercollar. Jacket has two inside coat pockets, center back vent, good natural shoulder — the Works! The slacks have "Ban-Rol®" inner waistband. Talon® zipper, deep no- hole pockets, and are 100% NO IRON Automatic WASH & WEAR ! The CLASSIC NftVY BLUE&K7//rf Fast, Reliable Service ( Haband sells direct thru the U.S. Mails to K over 2-million busy executives from Coast / to Coast. We specialize in a straight no- > nonsense deal: We will be proud to send / you our suit for your convenient, on- approval at-home inspection. Try it on. ^ Show the wife & family, and then decide 1978 is going to be the all time big year for the handsome Seersucker Summer Suit. -
Yanks Gaptiire Whole Forest Of
^ . The Weather Average Daily CircRlktinn Foreeiuit m i:. .h . wraiber Bdreai For the Month of 8fay. IW-I Fair, ttwalag nUghtly cooler In the Interior’ late tonight; ’TuMdn} 8,732 fair and aometvhat cooler with \ N e i e b e r o f t h e - A a W low humidity. \ Bareha of utjeohritaaa I Maneherter-^A City o f ViUage Charm X: (CtaMoifled AdrorUeBis oe Page MANCHESTER, CONN,, MONDAY, JUNE 12,1944 (TWELVE PAGES) PRICE m im E CENTS |vol ,L xiil NO. 2J5 le) »» | N- Yanks Gaptiire Whole Forest of ort \ 1 -. X 8'. Massive German Pillbox Sileiici |Strongest German Resistance in Air Is m.ric.b Flie^W Ing e on \, Invasion Forc^ Sue- w ceed in CariTlng Outj Fall o f (^arentan Ig Nol Help FoSter ^ Dive Bojtibing and “ ^ (Amfirinoil by A m ^ Reds Crack Missions Headquarters;, Am e^ Strafing Stomach Ills Behihd Nazi lanes. caus Within 14 Milea^ on ^ O f Cherliolirg; ThrcaL Wreme ijead,i«..ter.. Al-j en to Seal Off Tip ol ied Expeditionary . Force, Induce Vlcer»9 in Sug- i 'M u n c h fune 12.—<i<P)— U. S.' pilots ceptible Persons Med- Must Employ Cape; Caen Menaced bver France encountered to- By Eneirclenient. ly the strongest Luftwaffe ical Association Told. 'Nation Out o f War More People esistance since the invasion By Howard W. Blakeelee And Isolate Germans. Suf^Cme Headquarters, Al- egan. Eighth Air Force lied Expeditionary Force, [leadquarters annoUnc^ to- AssoHated I*re»s .Science Editor Chicago, June 12.— Itvldence Moscow', June 12.-*-(A*)— Thau Before June 12,-^yp)— A m e r i c a n light, but "pilots succeed that excessive amounts of caffetn