Ernst Schering Prize 2017
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Medical Advisory Board September 1, 2006–August 31, 2007
hoWard hughes medical iNstitute 2007 annual report What’s Next h o W ard hughes medical i 4000 oNes Bridge road chevy chase, marylaNd 20815-6789 www.hhmi.org N stitute 2007 a nn ual report What’s Next Letter from the president 2 The primary purpose and objective of the conversation: wiLLiam r. Lummis 6 Howard Hughes Medical Institute shall be the promotion of human knowledge within the CREDITS thiNkiNg field of the basic sciences (principally the field of like medical research and education) and the a scieNtist 8 effective application thereof for the benefit of mankind. Page 1 Page 25 Page 43 Page 50 seeiNg Illustration by Riccardo Vecchio Südhof: Paul Fetters; Fuchs: Janelia Farm lab: © Photography Neurotoxin (Brunger & Chapman): Page 3 Matthew Septimus; SCNT images: by Brad Feinknopf; First level of Rongsheng Jin and Axel Brunger; iN Bruce Weller Blake Porch and Chris Vargas/HHMI lab building: © Photography by Shadlen: Paul Fetters; Mouse Page 6 Page 26 Brad Feinknopf (Tsai): Li-Huei Tsai; Zoghbi: Agapito NeW Illustration by Riccardo Vecchio Arabidopsis: Laboratory of Joanne Page 44 Sanchez/Baylor College 14 Page 8 Chory; Chory: Courtesy of Salk Janelia Farm guest housing: © Jeff Page 51 Ways Illustration by Riccardo Vecchio Institute Goldberg/Esto; Dudman: Matthew Szostak: Mark Wilson; Evans: Fred Page 10 Page 27 Septimus; Lee: Oliver Wien; Greaves/PR Newswire, © HHMI; Mello: Erika Larsen; Hannon: Zack Rosenthal: Paul Fetters; Students: Leonardo: Paul Fetters; Riddiford: Steitz: Harold Shapiro; Lefkowitz: capacity Seckler/AP, © HHMI; Lowe: Zack Paul Fetters; Map: Reprinted by Paul Fetters; Truman: Paul Fetters Stewart Waller/PR Newswire, Seckler/AP, © HHMI permission from Macmillan Page 46 © HHMI for Page 12 Publishers, Ltd.: Nature vol. -
ERNST SCHERING PRIZE 2021 for Pioneering Basic Research in Biology, Medicine and Chemistry
CALL FOR NOMINATIONS ERNST SCHERING PRIZE 2021 for pioneering basic research in biology, medicine and chemistry Awarded annually by the Schering Stiftung, Berlin, the 50,000-euro Ernst Schering Prize is one of the most prestigious German science awards honoring scientists worldwide whose research has pioneered fundamental breakthroughs in biomedicine. A particular focus is on researchers performing future-oriented top-level research and engaging in both scientific and public debates. INFORMATION ON THE PRIZE & THE NOMINATION PROCEDURE Prize money 50,000 EUR | There are no conditions attached to the prize money Nomination criteria • Eligible for application are individual scientists worldwide • who perform biological, medical or chemical research in the field of biomedicine, • whose pioneering research has in recent years resulted in new and inspiring avenues or led to breakthroughs in biomedical knowledge, and • who actively participate in relevant debates between science and society, or who have started initiatives to guide future generations and inspire them to further their career. A special focus is on nominees actively pursuing their scientific goals for the benefit of society. Nominations will be accepted from established scientists as well as from scientific societies or organizations. Submission deadline February 17, 2021 Nomination documents • Ernst Schering Prize nomination form (PDF on our website: www.scheringstiftung.de) • Brief summary of the research for which the nominee is nominated, explaining its significance and the -
GSA Welcomes 2012 Board Members
7INTERs3PRING 4HE'3!2EPORTER winter s spring 2012 New Executive GSA Welcomes 2012 Board Members Director Now on Board The Genetics Society of America New Members of the GSA Board of welcomes four new members elected Directors Adam P. Fagen, by the general membership to the Ph.D., stepped in as 2012 GSA Board of Directors. The VICE PRESIDENT: GSA’s new Executive new members are: Michael Lynch Michael Lynch, Director beginning (Indiana University), who serves as Distinguished December 1, 2011. vice president in 2012 and as GSA Professor of Dr. Fagen previously president in 2013 and Marnie E. Biology, Class of was at the American Halpern (Carnegie Institution for 1954 Professor, Society of Plant Science); Mohamed Noor (Duke Department of Biologists (ASPB), University); and John Schimenti Biology, Indiana where he was the director of public (Cornell University), who will serve as University, continued on page nineteen directors. Bloomington. Dr. Lynch is a population and evolutionary biologist and a In addition to these elected officers, long-time member of GSA. Dr. Lynch 2012 Brenda J. Andrews (University of sees GSA as the home for geneticists Toronto), Editor-in-Chief of GSA’s who study a broad base of topics GSA Award journal, G3: Genes|Genomes|Genetics, and organisms, and as a forum Recipients which was first published online in where general discussion occurs, June 2011, becomes a member of the whether based on the principles Announced Board of Directors. The bylaws have of genetics, the most pressing historically included the GENETICS GSA is pleased to announce the issues within the discipline itself, or editor-in-chief on the Board and as a responses to societal concerns and/ 2012 recipients of its five awards result of a 2011 bylaw revision, the G3 for distinguished service in the or conflicts within applied genetics. -
A REVOLUTION in the PHYSIOLOGY of the LIVING CELL FUTURE ANNUAL MEETINGS of by Gilbert N
A REVOLUTION IN THE PHYSIOLOGY OF THE LIVING CELL FUTURE ANNUAL MEETINGS OF by Gilbert N. Ling Orig. Ed. 1992 404 pp. $64.50 THE AMERICAN SOCIETY FOR ISBN 0-89464-398-3 CELL BIOLOGY The essence of a major revolution in cell physiology -the first since the cell was recognized as the basic unit of life a century and a half ago - is presented and altemative theories are discussed in this text. Although the conventional mem- brane-pump theory is still being taught, a new theory of the living cell, called the association-induction hypothesis has been proposed. It has successfullywfthstood 1995 twenty-five years of worldwide testing and has already generated an enhancing DC diagnostic tool ofgreat power, magnetic resonance imaging (MRI).This volume is Washington, intended forteachers, students and researchers ofbiology and medicine. December 9-13 i't...a correct basic theory of cell physiology, besides its great intrinsic value in mankind's search forknowledge aboutourselves and the world we live in, willalso play a crucial role in the ultimate conquest of cancer, AIDS, and other incurable 1996 diseases.'-from the Introduction. ASCB Annual Meeting/ on Cell Biology t When ordering please add t".Ling turns cellphysiology upside down. He Sixth International Congress $5.00 first bookl$1.50 each ad- practicallyredefines the cell. He provides com- San Francisco, California ditional book to cover shipping pellingevidencefor headequacyofhis theoryn December 7-11 charges. Foreign shipping costs evidence that cannot fail to impress even the available upon request. most extreme skeptics....'- Gerald H. Pollock, _ Ph.D., Univ. ofWashington. -
Humankind 2.0: the Technologies of the Future 6. Biotech
Humankind 2.0: The Technologies of the Future 6. Biotech Piero Scaruffi, 2017 See http://www.scaruffi.com/singular/human20.html for the full text of this discussion A brief History of Biotech 1953: Discovery of the structure of the DNA 2 A brief History of Biotech 1969: Jon Beckwith isolates a gene 1973: Stanley Cohen and Herbert Boyer create the first recombinant DNA organism 1974: Waclaw Szybalski coins the term "synthetic biology” 1975: Paul Berg organizes the Asilomar conference on recombinant DNA 3 A brief History of Biotech 1976: Genentech is founded 1977: Fred Sanger invents a method for rapid DNA sequencing and publishes the first full DNA genome of a living being Janet Rossant creates a chimera combining two mice species 1980: Genentech’s IPO, first biotech IPO 4 A brief History of Biotech 1982: The first biotech drug, Humulin, is approved for sale (Eli Lilly + Genentech) 1983: Kary Mullis invents the polymerase chain reaction (PCR) for copying genes 1986: Leroy Hood invents a way to automate gene sequencing 1986: Mario Capecchi performs gene editing on a mouse 1990: William French Anderson’s gene therapy 1990: First baby born via PGD (Alan Handyside’s lab) 5 A brief History of Biotech 1994: FlavrSavr Tomato 1994: Maria Jasin’s homing endonucleases for genome editing 1996: Srinivasan Chandrasegaran’s ZFN method for genome editing 1996: Ian Wilmut clones the first mammal, the sheep Dolly 1997: Dennis Lo detects fetal DNA in the mother’s blood 2000: George Davey Smith introduces Mendelian randomization 6 A brief History of Biotech -
CNIO FRONTIERS Meetings 2011 Recapturing Pluripotency: Links Between Cellular Reprogramming and Cancer
Spanish National Cancer Research Centre CNIO FRONTIERS Meetings 2011 Recapturing Pluripotency: links between cellular reprogramming and cancer 7-9 NOVEMBER 2011 Organisers: Maria A. Blasco CNIO, Madrid, Spain Konrad Hochedlinger Harvard University and Howard Hughes Medical Institute, Boston, USA Manuel Serrano CNIO, Madrid, Spain Inder Verma The Salk Institute, La Jolla, USA CNIO FRONTIERS Meetings 2011 Spanish National Cancer Research Centre Recapturing Pluripotency: links between cellular reprogramming and cancer 7-9 November 2011 2 Recapturing Pluripotency: links between cellular reprogramming and cancer CNIO FRONTIERS Meetings 2011 Summary 5 Detailed Programme 13 Session 1 21 Session 2 29 Session 3 39 Session 4 47 Session 5 55 Speakers’ Biographies 79 Poster session 101 CNIO Frontiers Meetings 2012 105 Previous CNIO Frontiers Meetings and CNIO Cancer Conferences Recapturing Pluripotency: CNIO FRONTIERS links between cellular Meetings 2011 reprogramming and cancer Detailed programme 5 CNIO FRONTIERS Meetings 2011 Detailed programme MONDAY, November 7th 09:30 Welcome Address Maria A. Blasco & Konrad Hochedlinger Session I: PLURIPOTENCY Chair: Rudolf Jaenisch 09:45 Rudolf Jaenisch, Whitehead Institute for Biomedical Research, Cambridge, USA Stem cells, pluripotency and nuclear reprogramming 10:20 Pablo Menéndez, GENyO (Pfizer-Universidad de Granada-Junta de Andalucía Centre for Genomics and Oncological Research), Granada, Spain Short talk: Residual expression of ectopic reprogramming factors prevents differentiation of iPSCs generated -
Evolutionarily Conserved Protein ERH Controls CENP-E Mrna Splicing and Is Required for the Survival of KRAS Mutant Cancer Cells
Evolutionarily conserved protein ERH controls CENP-E PNAS PLUS mRNA splicing and is required for the survival of KRAS mutant cancer cells Meng-Tzu Wenga,b,c, Jih-Hsiang Leea, Shu-Chen Weid, Qiuning Lia, Sina Shahamatdara, Dennis Hsua, Aaron J. Schettere, Stephen Swatkoskif, Poonam Mannang, Susan Garfieldg, Marjan Gucekf, Marianne K. H. Kima, Christina M. Annunziataa, Chad J. Creightonh, Michael J. Emanuelei, Curtis C. Harrise, Jin-Chuan Sheud, Giuseppe Giacconea, and Ji Luoa,1 aMedical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; bGraduate Institute of Clinical Medicine, National Taiwan University, Taipei 100, Taiwan; cFar-Eastern Memorial Hospital, Taipei 220, Taiwan; dDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei 100, Taiwan; eLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; fProteomics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; gConfocal Microscopy Core Facility, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; hDepartment of Medicine and Dan L. Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030; and iDepartment of Genetics, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115 Edited by Bert Vogelstein, Johns Hopkins University, Baltimore, MD, and approved November 12, 2012 (received for review June 1, 2012) Cancers with Ras mutations represent a major therapeutic prob- anaphase-promoting complex (APC/C) that coordinately maintain lem. Recent RNAi screens have uncovered multiple nononcogene the fidelity of chromosome segregation (6). Symmetrical distribu- addiction pathways that are necessary for the survival of Ras mu- tion of chromosomes during mitosis is critical for genomic stability tant cells. -
Biologie Moléculaire De LA CELLULE Biologie Moléculaire De Sixième Édition
Sixième édition BRUCE ALEXANDER JULIAN DAVID MARTIN KEITH PETER ALBERTS JOHNSON LEWIS MORGAN RAFF ROBERTS WALTER Biologie moléculaire de LA CELLULE Biologie moléculaire de Sixième édition LA CELLULESixième édition Biologie moléculaire de moléculaire Biologie LA CELLULE LA BRUCE ALBERTS BRUCE ALBERTS ALEXANDER JOHNSON ALEXANDER JOHNSON JULIAN LEWIS JULIAN LEWIS DAVID MORGAN DAVID MORGAN MARTIN RAFF MARTIN RAFF KEITH ROBERTS KEITH ROBERTS PETER WALTER PETER WALTER -:HSMCPH=WU[\]\: editions.lavoisier.fr 978-2-257-20678-7 20678-Albers2017.indd 1-3 08/09/2017 11:09 Chez le même éditeur Culture de cellules animales, 3e édition, par G. Barlovatz-Meimon et X. Ronot Biochimie, 7e édition, par J. M. Berg, J. L. Tymoczko, L. Stryer L’essentiel de la biologie cellulaire, 3e édition, par B. Alberts, D. Bray, K. Hopkin, A. Johnson, A. J. Lewis, M. Ra", K. Roberts et P. Walter Immunologie, par L. Chatenoud et J.-F. Bach Génétique moléculaire humaine, 4e édition, par T. Strachan et A. Read Manuel de poche de biologie cellulaire, par H. Plattner et J. Hentschel Manuel de poche de microbiologie médicale, par F. H. Kayser, E. C. Böttger, P. Deplazes, O. Haller, A. Roers Atlas de poche de génétique, par E. Passarge Atlas de poche de biotechnologie et de génie génétique, par R.D. Schmid Les biosimilaires, par J.-L. Prugnaud et J.-H. Trouvin Bio-informatique moléculaire : une approche algorithmique (Coll. IRIS), par P. A. Pevzner et N. Puech Cycle cellulaire et cytométrie en "ux, par D. Grunwald, J.-F. Mayol et X. Ronot La cytométrie en "ux, par X. Ronot, D. -
Facultad De Ciencias Universidad Autónoma De San Luis Potosí
Boletín de La Ciencia en San Luis Facultad de Ciencias Universidad Autónoma de San Luis Potosí No.1, 8 de junio de 1998 Presentación Boletín de información científica y El noticiero radiofónico La Ciencia en tecnológica de la Facultad de Ciencias San Luis que recientemente celebró su quinto aniversario, ha cumplido un ciclo. Publicación semanal A partir de esta fecha dejará de transmitirse por Radio Universidad; sin embargo, para continuar su labor de Edición y textos difusión el contenido del noticiero Fís. J. Refugio Martínez Mendoza aparecerá en forma de boletín. Además para recalcar su dependencia de la Facultad de Ciencias se incluirá una Cualquier información, artículo o sección que trata sobre las noticias e anuncio deberá enviarse al editor informaciones académicas de la e-mail: [email protected] Facultad, con lo cual se pretende sirva Este boletín puede consultarse por como un enlace y un medio de Internet en la página de la UASLP comunicación interna. Agradecemos las facilidades que se le den a este Boletín, así como cualquier colaboración que la · Einstein sigue dando de que hablar comunidad de la Facultad de Ciencias y de la Universidad quiera realizar. · Ahora la oveja clonada es madre Ponemos a disposición de los estudiantes de la Facultad este medio para cualquier · Argenina, un nutriente importante opinión o inquietud académica que tengan que comunicar, con respecto al · Más sobre terapias para tratar el desarrollo de nuestra Facultad y de SIDA nuestra Universidad. En principio, siempre y cuando se respeten las formas · Dinosaurios y aves de relación respetuosa, no habrá censura; por lo que se pueden expresar opiniones y críticas “positivas”. -
Activity 1 and 2 Overview
2013 Holiday Lectures on Science OVERVIEW OF CANCER DISCOVERY ACTIVITIES Medicine in the Genomic Era EDUCATOR MATERIALS OVERVIEW OF CANCER DISCOVERY ACTIVITIES This educator guide provides support for two Cancer Discovery activities, both based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video featuring researcher Dr. Charles L. Sawyers. Students begin by watching the online video clip, Cancer as a Genetic Disease (http://www.hhmi.org/biointeractive/ cancer-genetic-disease-video-highlights), and completing the accompanying Video Worksheet. After that assignment, instructors can decide which of the two activities to use in class. Activity 1: Classifying Cancer Genes In Activity 1, students identify the locations on chromosomes of genes involved in cancer, or “cancer genes.” Using the set of 139 Cancer Gene Cards and associated chromosome posters, students discover the following: • About 140 human genes are currently known to be involved in cancer. • Cancer genes are located throughout the human genome. • The proportion of oncogenes versus tumor suppressor genes is roughly equal. • The main cellular processes affected by mutations in cancer genes are cell survival, cell fate, and genome maintenance. • One way to visualize genetic data is to map genes onto chromosomes. Activity 2: Examining Cancer Patient Data In Activity 2, students explore the genetic basis of cancer by examining cards that list genetic mutations found in the DNA of actual cancer patients. Small-group work spurs discussion about the genes that are mutated in different types of cancers and the cellular processes that the affected genes control. Students are asked to identify patterns and trends in the data. -
Communicating Biochemistry: Meetings and Events
© The Authors. Volume compilation © 2011 Portland Press Limited Chapter 3 Communicating Biochemistry: Meetings and Events Ian Dransfield and Brian Beechey Scientific conferences organized by the Biochemical Society represent a key facet of activity throughout the Society’s history and remain central to the present mission of promoting the advancement of molecular biosciences. Importantly, scientific conferences are an important means of communicating research findings, establishing collaborations and, critically, a means of cementing the community of biochemical scientists together. However, in the past 25 years, we have seen major changes to the way in which science is communicated and also in the way that scientists interact and establish collabo- rations. For example, the ability to show videos, “fly through” molecular structures or show time-lapse or real-time movies of molecular events within cells has had a very positive impact on conveying difficult concepts in presentations. However, increased pressures on researchers to obtain/maintain funding can mean that there is a general reluctance to present novel, unpublished data. In addition, the development of email and electronic access to scientific journals has dramatically altered the potential for communi- cation and accessibility of information, perhaps reducing the necessity of attending meetings to make new contacts and to hear exciting new science. The Biochemical Society has responded to these challenges by progressive development of the meetings format to better match the -
Research Organizations and Major Discoveries in Twentieth-Century Science: a Case Study of Excellence in Biomedical Research Hollingsworth, J
www.ssoar.info Research organizations and major discoveries in twentieth-century science: a case study of excellence in biomedical research Hollingsworth, J. Rogers Veröffentlichungsversion / Published Version Arbeitspapier / working paper Zur Verfügung gestellt in Kooperation mit / provided in cooperation with: SSG Sozialwissenschaften, USB Köln Empfohlene Zitierung / Suggested Citation: Hollingsworth, J. R. (2002). Research organizations and major discoveries in twentieth-century science: a case study of excellence in biomedical research. (Papers / Wissenschaftszentrum Berlin für Sozialforschung, 02-003). Berlin: Wissenschaftszentrum Berlin für Sozialforschung gGmbH. https://nbn-resolving.org/urn:nbn:de:0168-ssoar-112976 Nutzungsbedingungen: Terms of use: Dieser Text wird unter einer Deposit-Lizenz (Keine This document is made available under Deposit Licence (No Weiterverbreitung - keine Bearbeitung) zur Verfügung gestellt. Redistribution - no modifications). We grant a non-exclusive, non- Gewährt wird ein nicht exklusives, nicht übertragbares, transferable, individual and limited right to using this document. persönliches und beschränktes Recht auf Nutzung dieses This document is solely intended for your personal, non- Dokuments. Dieses Dokument ist ausschließlich für commercial use. All of the copies of this documents must retain den persönlichen, nicht-kommerziellen Gebrauch bestimmt. all copyright information and other information regarding legal Auf sämtlichen Kopien dieses Dokuments müssen alle protection. You are not allowed