A REVOLUTION in the PHYSIOLOGY of the LIVING CELL FUTURE ANNUAL MEETINGS of by Gilbert N

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A REVOLUTION IN THE PHYSIOLOGY OF THE LIVING CELL FUTURE ANNUAL MEETINGS OF by Gilbert N. Ling Orig. Ed. 1992 404 pp. $64.50 THE AMERICAN SOCIETY FOR ISBN 0-89464-398-3 CELL BIOLOGY The essence of a major revolution in cell physiology -the first since the cell was recognized as the basic unit of life a century and a half ago - is presented and altemative theories are discussed in this text. Although the conventional membrane-pump theory is still being taught, a new theory of the living cell, called the association-induction hypothesis has been proposed. It has successfullywfthstood 1995 twenty-five years of worldwide testing and has already generated an enhancing DC diagnostic tool ofgreat power, magnetic resonance imaging (MRI).This volume is Washington, intended forteachers, students and researchers ofbiology and medicine. December 9-13 i't...a correct basic theory of cell physiology, besides its great intrinsic value in mankind's search forknowledge aboutourselves and the world we live in, willalso play a crucial role in the ultimate conquest of cancer, AIDS, and other incurable 1996 diseases.'-from the Introduction. ASCB Annual Meeting/ on Cell Biology t When ordering please add t".Ling turns cellphysiology upside down. He Sixth International Congress $5.00 first bookl$1.50 each ad- practicallyredefines the cell. He provides com- San Francisco, California ditional book to cover shipping pellingevidencefor headequacyofhis theoryn December 7-11 charges. Foreign shipping costs evidence that cannot fail to impress even the available upon request. most extreme skeptics....'- Gerald H. Pollock, _ Ph.D., Univ. ofWashington. Please call or write for our Free Biology catalog 1997 KRIEGER PUBLISHING COMPANY Washington, DC OP. Box 9542 ' Melbourne, FL32902-9542 December 13-17 (407) 724-9542 ' Order Dept. (407) 727-7270 2 \/ ~~~FAX(407)951-3671 + Statement of Ownership, Management and Circulation (Required by 39 U. S C. 3685) 1A lleo P,lbl--tro I PUBLICATION NO Grl .'AlP rilin,g

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Editor-in-Chief Editor David Botstein Keith R. Yamamoto Stanford University School of Medicine University of California, San Francisco

Associate Editors J. Michael Bishop Carl-Henrik Heldin Erkki Ruoslahti University of California, San Francisco Ludwig Institute for Cancer Research, La Jolla Cancer Research Foundation Elizabeth H. Blackburn Uppsala, Sweden Gottfned Schatz University of California, San Francisco Kenneth Holmes University of Basel, Switzerland Michael S. Brown Max-Planck-Institut fur Medizinische Randy W. Schekman University of Texas Southwestern Forschung, Heidelberg, Germany University of California, Berkeley Medical Center, Dallas Tim Hunt Joseph Schlessinger Gerald R. Fink ICRF Clare Hall Labs, United Kingdom New York University Medical Center Whitehead Institute, Cambridge Richard Hynes Lucy Shapiro Joseph Gall Massachusetts Institute of Technology, Stanford University School of Medicine Carnegie Institution, Baltimore Cambridge Judith Kimble Timothy A. Springer Mary-Jane Gething University of Wisconsin, Madison Center for Blood Research, Boston University of Texas Southwestern James A. Spudich Medical Center, Dallas Marc W. Kirschner Harvard Medical School, Boston Stanford University School of Medicine Alfred G. Gilman Masatoshi University of Texas Southwestern Timothy J. Mitchison Takeichi Medical Center, Dallas University of California, San Francisco Kyoto University, Japan Roger Y. Tsien Joseph L. Goldstein Elliot Meyerowitz San University of Texas Southwestern California Institute of Technology, Pasadena Universityk of California, Diego Michael H. Medical Center, Dallas Thomas D. Pollard Wigler Guido Guidotti Johns Hopkins University, Baltimore Cold Spring Harbor Laboratory Harvard University, Cambridge Mitsuhiro Yanagida Martin Raff Kyoto University, Japan Leland Hartwell University College London, United Kingdom University of Washington, Seattle Joan Ruderman Harvard Medical School, Boston

Essay Editors Art & History Editor Managing Editor Bruce M. Alberts Joseph Gall Rosalba A. Kampman University of California, San Francisco Carnegie Institution, Baltimore The American Society for Cell Biology, Henry R. Bourne Bethesda University of California, San Francisco Editorial Board Ken-Ichi Arai James R. Feramisco Chris Kaiser Gerald M. Rubin William Balch Douglass J. Forbes Mary B. Kennedy Melvin Simon Mary Beckerle Thomas D. Fox Michael Klagsbrun William S. Sly Merton Bemfield Margaret T. Fuller Stuart Komfeld Solomon H. Snyder Michael Berridge Michael M. Gottesman Robert J. Lefkowitz Paul W. Steinberg Melanie Cobb Dan Gottschling Marc Mumby Antti Vaheri Gerald Crabtree Warner Greene Paul Nurse Denisa Wagner Tom Curran Ed Harlow Bjorn Olsen Peter Walter Benoit de Crombrugghe Tony Hunter Suzanne R. Pfeffer Paul M. Wassarman Gregor Eichele Rudolf Jaenisch Steven I. Reed Tadashi Yamamoto Marilyn Farquhar Elizabeth Jones Publication Staff Kevin Flynn Kathryn King Georgia Monitor Edward Newman Editorial Assistant Production Manager Subscriptions Advertising

Owned and pubLished by The American Society for Cell Biology, Elizabeth Marincola, Executive Director Cover Sixty years ago the German cytologist E. Heitz introduced the terms heterochromatin and euchromatin to distinguish parts of chromosomes that remain condensed throughout the cell cycle from those that undergo the usual cycle of condensation at mitosis and decondensation during interphase. Studies by Heitz and others on Drosophila were particularly helpful in defining the genetic properties of heterochromatin. The upper left photo on the cover shows a prophase of D. melanogaster in which each chromosome except the Y contains a large block of heterochromatin surrounding the centromere. The Y consists entirely of heterochromatin. Homologous regions of the euchromatin in the two longest chromosomes are paired, a peculiarity of the Diptera. The chromosomes of D. virilis in the upper right photo have a large block of heterochromatin next to the terminal centromere and a distal euchromatic segment. In this metaphase configuration the euchromatin and heterochromatin are both condensed but can be distinguished by the separated sister chromatids in the euchromatin. Genetic analysis of inversions and translocations showed that all but one or two of the known genes were in the euchromatin, and that large parts of the heterochromatin could be deleted without genetic consequences. When the polytene chromosomes were rediscovered in 1933 and compared with their mitotic counterparts, the heterochromatin again stood out as unusual: the banded arms consisted entirely of euchromatin, whereas the heterochromatin from all the chromosomes was drastically reduced in amount and fused into a single region called the chromocenter. As shown for D. virilis in the bottom panel, Heitz distinguished a small, highly condensed mass of a-heterochromatin in the middle of the chromocenter from a larger, more diffuse region of f,-heterochromatin. He believed that the a-heterochromatin corresponded to the blocks of heterochromatin on mitotic chromosomes, which had failed to replicate in step with the euchromatin during formation of the polytene condition. The nature of the fl-heterochromatin was (and still is) less certain. The molecular basis for the lack of genes in the heterochromatin remained a mystery for a number of years. The answer came eventually from in situ hybridization, which showed that the heterochromatin consists of very short DNA sequences repeated millions of times. Drosophila provides the classic example of constitutive heterochromatin, which is genetically inactive because of its non-coding DNA. By contrast, facultative heterochromatin consists of otherwise normal chromosomes or parts of chromosomes that become inactive (and condensed) at special times or in specific tissues. The inactive X in female mammals is a well-known example of facultative heterochromatin. Author Index to Volumes 1-5 Aarhus, R., 2, 203-209 Banting, G., 4, 93-105 Blum, J.S., 1, 403-413 Abraham, S.E., 3, 655-665 Barakat, H., 4, 1295-1306 Blumenberg, M., 1, 965-973 Acton, S.L., 4, 647-660 Baranski, K.J., 2, 905-913 Bocckino, S.B., 2, 841-850 Adamczewski, J.P., 3, 1279-1294; Barcelo, G., 3, 875-893 Bockaert, J., 3, 961-969 4, 541-553 Barnes, G., 3, 29-47 Bodary, S.C., 3, 989-998 Adams, A.E.M., 4, 459-468 Barrett, J.T., 3, 507-520 Boettiger, D., 2, 271-283 Adams, J.C., 5, 423-437 Bar-Shavit, R., 1, 453-463 Boguski, M., 2, 453-465 Adams, S.R., 4, 993-1002 Barzilai, N., 3, 941-951 Bohlen, P., 4, 135-144 Adler, W.H., 2, 95-103 Bates, R.C., 2, 1035-1044 Boissy, R., 5, 497-509 Admon, A., 4, 931-939 Batistatou, A., 3, 363-371 Bokoch, G.M., 4, 261-269, 1217-1223 Agre, M.C., 1, 279-290 Batzer, A., 4, 1175-1188 Boldogh, I., 5, 807-818 Agrez, M.V.,-2, 1035-1044 Bauer, D.W., 5, 633-644 Bolten, S., 3, 699-709 Akai, H., 1, 707-713 Baukal, A.J., 5, 17-27 Bominaar, A.A., 3, 603-612 Akeson, R., 1, 567-576 Baum, M., 5, 747-761 Bomsel, M., 3, 1317-1328 Aktories, K., 5, 1199-1213 Baum, P., 3, 1443-1454 Bomsztyk, K., 2, 329-335 Alanko, T., 2, 285-297 Baumgartner, R.A., 5, 475-484 Bonifacino, J.S., 5, 1093-1103 Albelda, S.M., 4, 973-982 Baumgartner, S., 3, 287-298 Bonventre, J.V., 2, 251-260 Albert, K.A., 2, 229-239 Bayard, F., 2, 709-718 Borchelt, D.R., 3, 851-863 Alberts, B.M., 3, 1-11 Bayley, H., 2, 211-218 Borisy, G.G., 2, 861-874 Alfa, C.E., 4, 1087-1096 Bayley, S.T., 3, 1107-1115 Bomstein, P., 1, 487-498 Alitalo, K., 2, 651-661 Beach, D., 4, 337-345, 897-906 Bossie, M.A., 3, 875-893 Al-Khodairy, F., 5, 147-160 Beagle, G.J., 5, 29-43 Boto, W.M.O., 2, 95-103 Altin, J.G., 2, 383-390; 3, 323-333 Beaven, M.A., 5, 475-484 Botstein, D., 3, 29-47, 789-803; Amalric, F., 2, 709-718; 4, 1239-1250 Beckerle, M.C., 1, 227-236 4, 1017-1025, 1307-1316 Amano, F., 1, 747-761 Beermann, M.L., 5, 863-875 Boulton, T.G., 2, 357-371, 965-978; Amat, J.A., 3, 1215-1228 Bellot, F., 1, 173-188 3, 197-209 Amon, A., 3, 805-818 Bement, W.M., 1, 315-326 Bourret, R.B., 4, 469-482 Anderson, D.M., 3, 197-209 Bender, C., 5, 129-134 Bowden, S., 4, 583-592, 1069-1076 Anderson, K.P., 4, 1077-1085 Bendori, R., 1, 621-636 Boyd, A.W., 2, 1035-1044 Andersson, M., 2, 503-512 Benedetti, H., 4, 511-521; 5, 1023-1037 Boyer, B., 1, 975-988 Andreasen, P.A., 1, 1043-1056 Benedict, S., 2, 479-489 Boynton, A.L., 3, 865-874 Andrews, S.B., 5, 1105-1118 Benezra, M., 1, 453-463 Bradham, D.M., 4, 637-645 Aneskievich, B., 2, 271-283 Bennink, J.R., 2, 549-563 Bradshaw, R.A., 2, 383-390; 3, 323-333 Angel, P., 1, 269-278 Ben-Ze'ev, A., 1, 621-636 Bradshaw-Rouse, J., 4, 757-765 Anraku, Y., 4, 1017-1025 Bergelson, J.M., 5, 977-988 Bray, D., 4, 469-482 Antebi, A., 3, 633-654 Berger, M.S., 2, 403-412 Brewster, R., 2, 767-779 Apgar, J.R., 2, 181-191; 5, 313-322 Berkower, C., 5, 1185-1198 Brezina, L., 1, 567-576 Arai, K., 4, 983-992; 5, 119-128 Berlin, R.D., 2, 915-925 Briesewitz, R., 4, 593-604; 5, 1215-1223 Arai, N., 5, 119-128 Bemasconi, C., 2, 927-938 Brill, J.A., 5, 297-312 Arkinstall, S.J., 2, 767-779 Bernfield, M., 1, 27-35; 5, 797-805 Bringhurst, F.R., 2, 889-896 Armstrong, J., 4, 583-592, 1069-1076 Berridge, M.J., 1, 75-86, 675-681, 853-861 Britten, R.J., 3, 403-414; 4, 375-387 Aruffo, A., 2, 347-355 Berse, B., 3, 211-220, 1169-1180 Brock, T., 4, 121-133 Asai, D.J., 5, 57-70 Besmer, P., 3, 349-362 Brodsky, F.M., 4, 647-660 Ashom, C.L., 5, 135-145 Besner, G., 1, 811-819 Brown, A.J., 5, 921-932 Ast, G., 5, 1341-1352 Betsholtz, C., 2, 503-512 Brown, D., 2, 251-260 Atherton-Fessler, S., 5, 989-1001 Beushausen, S., 2, 211-218 Brown, K.D., 1, 75-86 Audebert, S., 4, 615-626 Bevilacqua, M.P., 2, 347-355 Brown, L., 2, 95-103 Austin, L.R., 5, 549-563 Bezprozvannaya, S., 5, 97-103 Brown, L.F., 3, 211-220; 1169-1180 Autieri, M.V., 1, 1015-1025 Bezprozvanny, I., 5, 97-103 Bruneau-Wack, C., 2, 65-72 Ayscough, K., 5, 519-528 Bezprozvanny, I.B., 4, 347-352 Bruzzone, R., 3, 711-720; 4, 7-20 Azpiroz, R., 4, 21-36 Bhalla, R.C., 1, 301-313 Buchkovich, K.J., 5, 1225-1241 Bi, G., 4, 963-972 Buck, C.A., 4, 973-982 Bienz-Tadmor, B., 2, 875-888 Buck, J., 3, 349-362 Bilbe, G., 3, 287-298 Bugler, B., 4, 1239-1250 Birrell, G.B., 2, 1067-1079 Buhler, F.R., 1, 649-659, 821-831 Baba, T., 4, 715-727 Bishop, J.M., 4, 353-361 Bulboaca, G.H., 5, 839-849 Bachi, T., 2, 549-563 Bishop, W.R., 2, 897-903 Burgess, A.W., 3, 1235-1243 Baichwal, V., 3, 1117-1130 Bismuth, G., 2, 513-522 Burgess, W.H., 2, 87-93; 3, 85-93 Bailey, J., 5, 339-347 Bissell, M.J., 1, 45-54; 2, 739-752; Burgin, K.E., 5, 511-517 Bainton, D.F., 3, 309-321 3, 699-709 Burgstahler, A.D., 3, 113-121 Balla, T., 5, 17-27 Bizik, J., 1, 895-905; 2, 87-93, 1057-1065 Burmester, J.K., 2, 467-477 Ballard, D.W., 3, 1339-1352 Blackwood, E.M., 5, 597-609 Bums, G.F., 2, 1035-1044 Ballotti, R., 4, 737-746 Blanchard, J.-M., 2, 575-588 Burridge, K., 5, 349-361 Bamberger, M., 2, 251-260 Blasi, F., 2, 793-803 Butow, R.A., 4, 21-36 Bandara, L.R., 5, 1081-1092 Blish, C., 5, 763-772 Byers, B., 3, 805-818, 1443-1454

Caddle, M.S., 5, 839-849 Clarke, L., 5, 747-761 Dedman, J.R., 1, 165-172 Cahalan, M.D., 1, 99-112 Clarke, M., 3, 1403-1413 Defilippi, P., 2, 1021-1033 Cai, J., 4, 1109-1119 Clarke, P.R., 4, 397-411 deGraffenried, L.A., 4, 185-194 Caleb, B.L., 1, 435-443 Clary, D.O., 5, 549-563 DeHoratius, C., 3, 875-893 Callow, M., 5, 173-181 Cleveland, D.W., 5, 645-654 Dell'Era, P., 2, 719-726 Calos, M.P., 5, 839-849 Cobb, M., 3, 197-209 Delwel, G.O., 5, 203-215 Campbell, C.L., 5, 899-905 Cobb, M.H., 2, 357-371, 965-978; DeMaggio, A.J., 5, 877-886 Campbell, J.L., 4, 195-208 3, 299-308, 1141-1154 de Melker, A.A., 5, 203-215 Campisi, J., 1, 215-226 Coffman, F.D., 1, 1015-1025 Denetclaw, W.F., Jr., 4, 963-972; Campos-Gonzaez, R., 2, 663-673 Cohen, P., 4, 669-677 5, 1159-1167 Candido, E.P.M., 3, 221-233 Cohen, S., 1, 1015-1025 Denoulet, P., 4, 615-626 Capco, D.G., 1, 315-326 Cole, G.J., 1, 567-576 Dent, P., 4, 483-493; 5, 1243-1251 Caplan, A.J., 4, 555-563 Collier, R.J., 3, 1269-1277 DePaoli-Roach, A.A., 3, 687-698 Capponi, A.M., 2, 767-779 Colombo, M.I., 1, 113-124 Derynck, R., 2, 599-612 Carlberg, K., 5, 81-95 Concino, M.F., 1, 907-919 Desai, D., 3, 571-582 Carmel, G., 5, 877-886 Connell-Crowley, L., 4, 79-92 Desbruyeres, E., 4, 615-626 Caron, M.G., 1, 445-451 Conroy, L., 4, 261-269 Deshaies, R., 3, 129-142 Carpentier, J.-L., 2, 41-55 Cooper, E.M., 5, 29-43 Deuter-Reinhard, M., 5, 105-118 Carr, A.M., 5, 147-160 Cooper, H.M., 2, 427-438 Deutsch, P.J., 3, 941-951 Carrel, F., 5, 7-16 Cooper, J.A., 2, 413-425; 3, 583-592; Devreotes, P.N., 3, 603-612, 1229-1234; Carson, G.R., 1, 907-919 4, 49-57, 459-468, 907-917 4, 283-292; 5, 691-702, 703-711 Carter, M.C., 3, 655-665 Coorssen, J.R., 1, 1027-1041 Dharmawardhane, S., 5, 7-16 Casperson, G.F., 3, 699-709 Corey, J.L., 1, 531-541 Dhillon, N., 5, 877-886 Casscells, W., 2, 241-249 Cork, R.J., 1, 543-554 Di, Y-P., 4, 1109-1119 Castellot, J.J., Jr., 1, 435-443 Corps, A.N., 1, 75-86 Diaz, R., 1, 113-124 Castle, D., 4, 0483-493 Cosson, J., 5, 1051-1063 Diglio, C.A., 2, 1045-1055 Catt, K.J., 5, 17-27 Couchman, J.R., 4, 605-613; 5, 183-192 DiMario, P.J., 4, 1189-1204 Cavadore, J.-C., 2, 575-588 Couderc, B., 2, 709-718 Dimster-Denk, D., 5, 655-665 Cereghini, S., 4, 59-69 Cox, G.A., 5, 1159-1167 Dinh, D.P., 2, 819-826 Chamberlain, J.S., 5, 1159-1167 Crable, S.C., 4, 1077-1085 Dinh, T.T., 2, 299-309 Chambon, P., 1, 291-299 Craighead, M.W., 4, 583-592, 1069-1076 DiPersio, C.M., 4, 59-69 Champlin, D.T., 5, 71-79 Crausaz, F., 5, 1023-1037 Dirksen, E.R., 1, 585-596 Chan, P.-Y., 3, 157-166 Creancier, L., 4, 1239-1250 Disdier, M., 3, 309-321 Chang, F., 1, 391-401; 3, 445-450 Cremel, G., 2, 65-72 Dixon, D.K., 3, 221-233 Chappel, J.C., 1, 403-413 Crossley, I., 2, 121-133; 3, 373-383 Djaffar, I., 2, 347-355 Chappell, T.G., 5, 519-528 Crouch, D.H., 5, 1177-1184 Dobek, E.A., 2, 897-903 Charles, A.C., 1, 585-596 Cubitt, A.B., 3, 735-747 Dohi, Y., 1, 649-659 Chatani, Y., 1, 747-761 Culbertson, M.R., 5, 1065-1080 Donoghue, D.J., 3, 73-84; 5, 587-596 Cheek, T.R., 1, 75-86 Cunha-Melo, J.R., 5, 475-484 Doree, M., 4, 1295-1306 Cheever, L., 1, 693-706 Cunningham, G.R., 2, 841-850 Douglas, M.G., 4, 555-563 Chen, H.-C., 5, 413-421 Cumutte, J.T., 4, 261-269, 1217-1223 Dower, S.K., 2, 329-335 Chen, L.-H., 1, 45-54 Currie, K.P.M., 3, 1415-1425 Draetta, G., 4, 397-411 Chen, S., 5, 1253-1263 Cutts, J.L., 2, 627-640 Drechsel, D.N., 3, 1141-1154, 1155-1167 Chenevert, J., 5, 1169-1175 Cybulsky, M.I., 2, 347-355 Drickamer, K., 1, 471-486 Cheng, H.-J., 5, 943-953 Cyr, D.M., 4, 555-563 Dror, R., 2, 105-120 Cheng, Q.-L., 3, 749-759 Drubin, D.G., 3, 429-444; 4, 459-468, Cheng, Y.-F., 2, 805-817 1277-1294; 5, 617-632 Chew, C.S., 2, 27-39 Du, X., 1, 883-893 Cheyette, T.E., 2, 827-840 Dahlseid, J.N., 5, 1265-1275 Dunn, K.W., 4, 1251-1266 Chiang, J.J., 1, 301-313 Dahmann, C., 3, 805-818 Dupont, G., 1, 853-861 Chiba, K., 4, 1027-1034 Daily, D.R., 4, 885-896 Durden, D.L., 2, 413-425 Chiba, S., 1, 327-335 Dalton, M.A., 5, 739-746 Dvorak, H.F., 3, 211-220, 1169-1180 Chikashige, Y., 3, 819-835 Daly, R.J., 4, 1175-1188 Chiquet, M., 2, 927-938 D'Andrea, R.J., 4, 1161-1174 Chiquet-Ehrismann, R., 2, 927-938; 5, 439- Danesh, S., 3, 865-874 453 Danielpour, D., 1, 87-97; 2, 467-477, Earwicker, D., 1, 731-740 Choi, Y., 1, 791-809; 2, 613-625 535-548 Ebbesen, P., 1, 1043-1056 Chou, S.-y., 3, 1117-1130 Daniels, M.P., 5, 1105-1118 Ebner, R., 2, 599-612 Chow, Y.-K., 1, 125-134 Dan0, K., 2, 793-803 Edde, B., 4, 615-626 Chrest, J., 2, 95-103 Dargie, P.J., 1, 279-290 Edwards, S.N., 5, 1325-1339 Christensen, E.I., 1, 1043-1056 Damell, J.E., Jr., 3, 1085-1094 Ehrlich, B.E., 4, 347-352; 5, 97-103 Chun, J.-S., 3, 481-492; 4, 271-281 Dautigny, A., 2, 819-826 Eisenman, R.N., 5, 597-609 Chung, S.W., 4, 695-704 Davidson, E.H., 3, 403-414; 4, 375-387 Eistetter, H.R., 2, 767-779 Church, D.J., 2, 767-779 Davidson, M.M.L., 1, 1027-1041 Elble, R., 3, 971-980 Churcher, Y., 1, 337-346, 523-530 Davis, L.I., 4, 209-222 Eldar, H., 3, 1049-1056 Clark, A.M., 5, 7-16 Deanin, G.G., 2, 627-640 Elder, P.K., 3, 1073-1083 Clark, I.B., 5, 1301-1310 Deaton, J.D., 3, 1427-1435 Eldor, A., 1, 453-463, 833-842 Clark, K.L., 2, 781-792 DeBiasio, R.L., 3, 1037-1048 Elgin, S.C.R., 3, 593-602 Clark, S.W., 5, 1301-1310 Decker, S.J., 2, 691-697 Eli, Y., 2, 1011-1019

1354 Molecular Biology of the Cell Author Index

Elion, E.A., 4, 495-510; 5, 297-312 Fujimori, T., 4, 37-47 Gliniak, B.C., 3, 535-544 Emr, S.D., 3, 415-427 Fukayama, S., 2, 889-896 Glover, D.M., 3, 287-298 Engvall, E., 1, 731-740 Fuller, G.M., 3, 103-112; 5, 819-828 Goalstone, M., 4, 435-443 Epel, D., 1, 65-74 Fuller, R.S., 3, 1353-1371 Gober, J.W., 3, 913-926 Eppenberger, U., 2, 491-502 Funabiki, H., 3, 819-835 Godfrey, P.P., 2, 767-779 Epstein, H.S., 1, 965-973 Funasaka, Y., 3, 197-209 Goebl, M., 2, 781-792; 3, 263-273 Erikson, R.L., 3, 1329-1337 Furcht, L.T., 4, 605-613 Goetsch, L., 3, 805-818, 1443-1454 Esquela, A., 4, 695-704 Furman, M.I., 3, 1015-1024 Goitein, R., 5, 1341-1352 Etscheid, B.G., 2, 229-239 Futcher, B., 3, 805-818 Goldberger, O.A., 5, 797-805 Evers, M.E., 5, 829-837 Goldbeter, A., 1, 853-861 Exton, J.H., 2, 841-850 Goldman, C.K., 4, 121-133 Goldschmidt-Clermont, P.J., 1, 937-950; Gabrielli, B., 5, 989-1001 3, 1015-1024 Gagnon, C., 5, 1051-1063 Gomperts, B.D., 1, 337-346, 523-530 Fabbro, D., 2, 491-502 Galas, S., 4, 1295-1306 Gonda, Y., 1, 237-248 Fafeur, V., 4, 135-144 Galione, A., 3, 1415-1425 Gonzalez-Kuyvenhoven, M., 5, 135-145 Falcone, D.J., 4, 315-322 Gall, J.G., 3, 249-261; 5, 633-644, Goode, N.T., 5, 907-920 Fan, B., 3, 197-209 1119-1127 Goodenough, D.A., 3, 711-720; 5, 363-373 Fang, H., 5, 933-942 Gallagher, I.M., 4, 1087-1096 Goodman, J.M., 4, 223-232 Fankhauser, C., 4, 531-539 Gallego, C., 3, 123-128 Gorbsky, G.J., 5, 1243-1251 Farooqui, J., 5, 497-509 Gallo, R.L., 5, 797-805 Gorodecki, B., 1, 621-636 Farquhar, M.G., 4, 413-424 Ganchi, P.A., 3, 1339-1352 Gottesman, M.M., 3, 507-520 Fausto, N., 2, 535-548 Gannon, J., 3, 1279-1294 Graupner, G., 2, 565-574 Fazeli, B., 4, 953-961 Garabedian, M.J., 3, 1245-1257 Gray, L.S., 4, 173-184 Feldheim, D., 4, 931-939 Garbers, D.L., 5, 1-5 Green, J.M., 5, 1265-1275 Fenton, J.W., II, 1, 453-463 Gardner, A.M., 5, 193-201 Green, N., 5, 933-942 Fenton, S.E., 4, 773-780 Garen-Fazio, S., 1, 125-134 Greene, L.A., 3, 363-371; 4, 71-78 Feramisco, J.R., 4, 705-713 Garrett, S., 5, 529-538 Greene, W.C., 3, 1339-1352 Ferguson, K., 2, 155-164 Gaskins, C., 5, 691-702 Greenfeder, S.A., 3, 999-1013 Fernandez, A., 2, 575-588 Gaspera, B.D., 2, 819-826 Grewal, N., 3, 721-734 Ferralli, J., 5, 511-517 Gauthier-Rouviere, C., 2, 575-588 Griffith, O.H., 2, 1067-1079 Ferrara, N., 4, 1317-1326 Gavrilovic, J., 1, 1003-1014 Griffiths, D.J.F., 5, 147-160 Ferreira, A., 4, 1225-1238 Geiger, B., 2, 105-120 Grim, M.G., 4, 695-704 Ferrell, J.E., Jr., 3, 1117-1130 Gepner, J., 5, 45-55 Grofova, M., 1, 895-905 Ferrigno, P., 4, 669-677 Gerbi, S.A., 2, 875-888 Gros, F., 4, 615-626 Field, J., 3, 167-180 Gerke, V., 4, 569-581 Gross, D.J., 2, 827-840; 3, 493-505 Figard, P.H., 1, 13-25 Gerst, J., 3, 167-180 Grotendorst, G.R., 4, 637-645 Finberg, R.W., 5, 977-988 Gerton, G.L., 2, 1097-1113 Gruenstein, E., 4, 293-302 Fincham, V.J., 5, 1177-1184 Gese, E., 3, 761-773 Gruszczynski, C., 4, 615-626 Fink, G.R., 3, 633-654; 4, 209-222; Getz, M.J., 3, 1073-1083 Gu, Y., 3, 571-582 5, 297-312, 1003-1022 Giancotti, F.G., 4, 871-884, 973-982 Guan, J.-L., 1, 597-604; 2, 951-964; 5, 413- Finlay, B.B., 5, 455-464 Gibbons, B.H., 5, 57-70 421 Firpo, E.J., 3, 389-401 Gibbons, I., 5, 45-55 Gudas, L.J., 3, 189-196 Firtel, R.A., 3, 735-747; 5, 7-16, 691-702 Gibbons, I.R., 5, 57-70 Guerrero, T., 3, 1427-1435 Fischer, R., 2, 337-345 Gil, R., 2, 41-55 Gupta, S.K., 3, 123-128 Fitch, I., 3, 805-818 Gilbert, L.I., 1, 771-780 Gusovsky, F., 5, 475-484 Flanagan, J.G., 5, 943-953 Gilbert, T., 1, 471-486 Flanders, K.C., 1, 87-97; 2, 467-477 Gill, G.N., 5, 539-547 Flaumenhaft, R., 3, 1057-1065 Gill, S.R., 5, 645-654 Fleming, A.M., 4, 747-756 Gillespie, G.Y., 4, 121-133 Haaparanta, T., 1, 731-740 Fles, D.L.A., 5, 203-215 Gilliland, L.K., 4, 523-530 Hack, N., 2, 641-649 Florio, M., 5, 283-296 Gilman, A.G., 3, 49-61 Haeffiger, J.-A., 4, 7-20 Florkiewicz, R., 2, 699-708 Gilmore, R., 5, 887-897 Hahn, A.W.A., 1, 649-659, 821-831 Flucher, B.E., 5, 1105-1118 Gimlich, R.L., 4, 7-20 Haimovich, B., 2, 271-283 Fogarty, P., 4, 885-896 Ginsberg, M.H., 1, 883-893 Hainaut, P., 2, 317-327 Fore, M.L., 2, 627-640 Giorgetti, S., 2, 317-327 Hajibagheri, M.A.N., 5, 519-528, 907-920 Foster, D.N., 3, 1073-1083 Girling, R., 5, 1081-1092 Halaban, R., 3, 197-209 Fotou, E., 5, 147-160 Giuliano, K.A., 3, 1037-1048 Hall, A., 3, 475-479 Fox, T.D., 4, 1327-1335 Givol, D., 1, 173-188; 2, 337-345 Hall, D., 5, 667-678 Frame, M.C., 5, 1177-1184 Glantz, S.B., 3, 1215-1228 Hall, M.N., 5, 105-118 Francesconi, S., 4, 145-157 Glass, A.A., 1, 883-893 Hamada, J., 4, 1205-1216 Franzusoff, A., 3, 789-803 Glass, D.J., 3, 677-686 Hampton, B.S., 3, 85-93 Freedberg, I.M., 1, 965-973 Gleavy, J., 2, 479-489 Hann, S.R., 1, 215-226 Fresa, K.L., 1, 1015-1025 Glenney, J.R., Jr., 2, 663-673 Hanna, P.C., 3, 1269-1277 Frizzell, R.A., 1, 951-963 Glick, A.B., 1, 87-97 Hannan, R., 5, 955-966 Fuchs, E., 1, 791-809; 2, 613-625 Glick, B.S., 5, 465-474 Hansen, L.K., 5, 967-975, 1281-1288 Fuchs, J.A., 3, 1095-1105 Glick, D.L., 2, 211-218 Hantzopoulos, P., 3, 677-686 Fugate, R.D., 3, 309-321 Gliemann, J., 1, 1043-1056 Harder, W., 5, 829-837 Fujiki, H., 1, 269-278 Gliksman, N.R., 4, 1035-1050 Harding, C.V., 1, 499-509

Vol. 5, December 1994 1355 Author Index

Harkonen, P., 2, 1-11 Howard, B.D., 1, 511-521 Jones, D., 3, 221-233 Harootunian, A., 1, 259-268 Howard, T.H., 3, 1427-1435 Jones, H.D., 4, 1277-1294 Harootunian, A.T., 4, 993-1002 Howlett, J., 2, 1045-1055 Jones, J.C.R., 2, 427-438 Harper, J.W., 4, 79-92 Huang, E.J., 3, 349-362 Jones, P.F., 2, 1001-1009 Hartwell, L., 3, 837-838 Huang, E.-S., 3, 1131-1139 Jones, T., 5, 921-932 Haslam, R.J., 1, 1027-1041 Huang, L.S., 5, 395-411 Jordan, K.L., 5, 667-678 Haslberger, A., 3, 451-460 Huang, S., 3, 555-569 Jouanneau, J., 1, 1003-1014; 5, 851-862 Hatier, C., 2, 739-752 Huber, B.T., 1, 425-434 Jung, V., 3, 721-734 Hauri, H.-P., 4, 679-693 Hubert, P., 2, 65-72 Just, I., 5, 1199-1213 Haverstick, D.M., 4, 173-184 Huffaker, T.C., 5, 29-43 Hays, T.S., 5, 45-55, 57-70 Hui, S.-W., 2, 57-64 Heasley, L.E., 2, 479-489; 3, 545-553 Huitorel, P., 5, 1051-1063 Hedberg, K.K., 2, 1067-1079 Hultsch, T., 3, 981-987 Kabiling, A.N., 2, 165-179 Heideman, W., 4, 757-765 Humphrey, J.S., 5, 1093-1103 Kadowaki, T., 5, 1253-1263 Heine, M.A., 4, 1189-1204 Hunt, T., 3, 1279-1294; 4, 541-553 Kaetzel, M.A., 1, 165-172 Heine, U.I., 2, 467-477 Hunter, T., 5, 273-282, 877-886 Kaftan, E., 4, 347-352 Heldin, C.-H., 1, 555-566, 577-584; Hy-Am, E., 1, 453-463 Kalman, D., 4, 353-361 2, 503-512 Hyams, J.S., 4, 1087-1096 Kamboj, R.K., 1, 715-729 Helenius, A., 5, 253-265 Hyman, A.A., 3, 1141-1154, 1155-1167 Kane, L.P., 2, 753-765 Helliwell, S.B., 5, 105-118 Hynes, N.E., 4, 849-858 Kanemitsu, M.Y., 3, 865-874; 4, 837-848 Hellman, U., 1, 577-584 Hynes, R.O., 1, 597-604; 2, 951-964 Kanstein, M., 5, 237-252 Hellmich, M.R., 2, 193-202, 211-218 Karin, M., 1, 269-278 Hemler, M.E., 5, 977-988 Karnovsky, M.J., 1, 435-443 Hemmings, B.A., 2, 491-502, 1001-1009; Karsenti, E., 4, 397-411 3, 287-298 lacopetta, B., 2, 41-55 Kashishian, A., 4, 49-57 Henderson, G.S., 2, 841-850 Igarashi, A., 4, 637-645 Katada, T., 4, 1027-1034 Hendricks, L.C., 4, 413-424 Ikai, A., 1, 237-248 Katz, M.E., 1, 1015-1025 Henrich, C.J., 1, 693-706; 2, 1081-1095 Ilic, D., 2, 979-987 Kawaguchi, S., 5, 977-988 Henriquez, R., 5, 105-118 Inagaki, M., 1, 237-248; 5, 161-172 Kawamukai, M., 2, 155-164; 3, 167-180 Her, J.-H., 5, 1243-1251 Ingber, D.E., 5, 389-393, 967-975, Kawashima, E., 2, 767-779 Hermann, T., 2, 565-574 1281-1288 Kazatchkine, M., 2, 41-55 Herrmann, J.L., 4, 1205-1216 Insall, R., 3, 1229-1234 Kazlauskas, A., 2, 413-425 Herskowitz, I., 1, 391-401; 3, 445-450; Insall, R.H., 5, 703-711 Kearns, A.K., 2, 889-896 4, 107-120 Ip, N.Y., 3, 677-686 Keller, G.-A., 3, 749-759; 4, 1317-1326 Heydt, C., 5, 763-772 Ishal-Michaeli, R., 1, 833-842 Kelley, L.L., 2, 841-850 Heyworth, P.G., 4, 261-269, 1217-1223 Ito, E., 1, 347-357 Kellogg, D.R., 3, 1-11 Hibbs, M.L., 1, 359-367 Iwasaki, T., 2, 329-335 Kennedy, M.B., 4, 159-172 Hicke, L., 3, 667-676 Izumi, T., 3, 927-939; 4, 1337-1350 Kennerly, D.A., 2, 299-309 Higashiyama, S., 1, 811-819 Kern, A., 4, 593-604 Hill, K.J., 5, 1039-1050 Khaner, H., 1, 693-706 Hille, M.B., 1, 1057-1067 Killen, P.D., 2, 219-227 Himmel, K.L., 5, 1065-1080 Jackson, A.P., 4, 647-660 Kim, C.W., 5, 797-805 Hiraoka, Y., 4, 1003-1015 Jacobson, B.S., 3, 481-492; 4, 271-281 Kim, J., 4, 121-133 Hirata, A., 5, 1129-1143 Jaffe, L.A., 1, 465-469 Kim, K.Y., 1, 269-278 Hirokawa, N., 1, 237-248; 3, 1181-1194; Jaken, S., 2, 491-502 Kim, S.-J., 1, 269-278 5, 161-172 Jakowlew, S.B., 2, 535-548 Kimble, J., 3, 461-473, 1199-1213 Hirsch, D.J., 3, 621-631 Jakubowicz, T., 2, 1001-1009 Kincaid, R., 4, 1225-1238 Hisanaga, S., 1, 237-248; 5, 161-172 Jalkanen, M., 2, 1-11; 4, 849-858; King, M.W., 5, 597-609 Hitomi, M., 5, 1253-1263 5, 1325-1339 King, V., 4, 121-133 Hitzemann, K., 5, 339-347 Jans, D.A., 2, 491-502 Kingsbury, J., 4, 859-870 Hoekstra, M.F., 5, 877-886 Jantsch, M., 3, 249-261 Kinoshita, N., 4, 303-313 Hofer, U., 2, 927-938 Jarett, L., 2, 1097-1113 Kirihara, J.M., 4, 523-530 Hoffmann, I., 4, 397-411 Jarpe, M., 2, 383-390 Kirjavainen, J., 4, 849-858 Hogervorst, F., 5, 203-215 Jaspars, L.H., 5, 203-215 Kirk, K.L., 1, 951-963 Hohman, R.J., 3, 981-987 Jaynes, C., 4, 435-443 Kirschner, M.W., 3, 13-27, 1141-1154; Hoitta, E., 2, 651-661 Jenness, D.D., 2, 439-452 5, 323-338 Holzbaur, E.L.F., 5, 1301-1310 Jensen, P.H., 1, 1043-1056 Kitajewski, J., 3, 521-533 Honegger, A.M., 1, 173-188 Jensen, P.J., 1, 843-852 Klagsbrun, M., 1, 811-819 Honn, K.V., 2, 1045-1055 Jensen, R.E., 5, 529-538 Klausner, R.D., 4, 1-5 Hood, L., 3, 761-773 Jiang, C.-K., 1, 965-973 Klein, S., 4, 973-982 Hook, M., 3, 181-188 Jiang, J.X., 5, 363-373 Knaus, U.G., 4, 261-269, 1217-1223 Hopf, F.W., 5, 1159-1167 Jimenez-Garcia, L.F., 5, 955-966 Kobayashi, H., 3, 1279-1294 Horazdovsky, B.F., 3, 415-427 John, U.P., 4, 1161-1174 Kobilka, B.K., 1, 445-451 Horn, M., 4, 93-105 Johnson, A.D., 1, 543-554 Kochi, S., 3, 1269-1277 Hosang, M., 1, 821-831 Johnson, D.I., 4, 1307-1316 Kodoyianni, V., 3, 1199-1213 Hoshi, M., 4, 1027-1034 Johnson, G.L., 2, 479-489; 3, 123-128, Koedam, J.A., 4, 791-801 Hosobuchi, M., 3, 129-142 545-553; 5, 193-201 Koerber, R., 3, 451-460 House, F.S., 2, 841-850 Johnson, L.S., 4, 1251-1266 Koesling, D., 5, 1-5 Howald-Stevenson, I., 3, 1389-1402 Jonas, J.-C., 5, 1199-1213 Kohno, M., 1, 747-761

1356 Molecular Biology of the Cell Author Index

Kokel, M., 4, 1175-1188 Lee, R.W.H., 3, 1107-1115 Machesky, L.M., 1, 937-950 Kolega, J., 3, 1037-1048; 4, 819-836 Lee, T., 3, 13-27 Madden, K., 3, 1025-1035 Komachi, K., 1, 391-401 Lee, T.H., 5, 323-338 Maeda, K., 3, 1181-1194 Kondaiah, P., 2, 241-249 Lefkowitz, R.J., 1, 445-451 Magnaldo, I., 1, 445-451 Kong, X.-P., 3, 953-957 Lehmann, A.R., 5, 147-160 Magun, B.E., 1, 379-390 Konopka, J.B., 2, 439-452 Lehner, C.F., 4, 1161-1174 Mahoney, M.G., 3, 493-505 Kontani, K., 4, 1027-1034 Lehtola, L., 2, 651-661 Maihle, N.J., 5, 339-347 Korf, G.M., 3, 1073-1083 Lehtonen, E., 2, 285-297 Maine, E.M., 3, 1199-1213 Kombluth, S., 5, 273-282 Le Marchand-Brustel, Y., 2, 65-72 Maller, J.L., 3, 73-84, 687-698, 927-939; Korzelius, C.A., 1, 249-257 Lennon, V.A., 2, 373-381 4, 1337-1350 Koshland, D., 4, 859-870 Leppa, S., 2, 1-11; 4, 849-858 Mandel, G., 1, 465-469 Kosik, K.S., 4, 1225-1238 Levine, R.A., 1, 215-226 Mandelkow, E., 4, 323-335 Kotecha, S., 5, 1081-1092 Levinson, A.D., 3, 989-998 Mandelkow, E.-M., 4, 323-335 Koulakoff, A., 4, 615-626 Levy, A.D., 4, 803-817 Maneckjee, R., 3, 613-619 Kowalik, T.F., 3, 1131-1139 Lew, D.P., 2, 41-55 Manning, D.R., 2, 1097-1113 Kowalski, A., 2, 317-327 Lewis, J.M., 2, 1097-1113 Manseau, E.J., 3, 1169-1180 Kowalski-Chauvel, A., 4, 737-746 Lewis, R.S., 1, 99-112 Marcantonio, E.E., 1, 597-604; 4, 593-604; Krabak, M., 2, 57-64 Li, G., 5, 1199-1213 5, 1215-1223 Kramer, Ij.M., 1, 523-530 Li, W., 2, 641-649 Marchetti, D., 4, 1205-1216 Kramer, J.M., 4, 803-817 Lill, R., 5, 1265-1275 Marcus, S., 4, 107-120 Kramer, R.H., 2, 805-817 Lim, R., 1, 741-746 Marengere, L.E.M., 4, 1175-1188 Kranz, J.E., 4, 495-510 Lin, H., 4, 1109-1119 Margolis, B., 2, 641-649 Kreiner, T., 1, 415-424 Lindberg, R.A., 5, 877-886 Markwardt, D., 4, 757-765 Kretzner, L., 5, 597-609 Lindblom, A., 5, 203-215 Marraccino, R.L., 3, 389-401 Kron, S.J., 5, 1003-1022 Linderman, J.J., 3, 493-505 Marshak, D.R., 3, 85-93 Kruse, K.B., 4, 729-736 Lindquist, S., 1, 135-149 Martin, G.S., 5, 283-296 Kuang, J., 5, 135-145 Lindsay, N.S., 3, 677-686 Martin, R., 3, 981-987 Kubalek, E.W., 3, 1455-1462 Lindsley, K.A., 1, 661-674 Martinez-Serrano, A., 3, 235-248 Kuikman, I., 5, 203-215 Lingrel, J.B., 4, 1077-1085 Martins-Green, M., 2, 739-752 Kumar, V., 1, 291-299 Linstedt, A.D., 4, 679-693 Maruta, H., 3, 1437-1442 Kunz, J., 5, 105-118 Lis, J.T., 5, 71-79 Marx, A., 4, 323-335 Kurata, W.E., 3, 865-874 Liscovitch, M., 2, 1011-1019 Mason, J.O., 3, 521-533 Kuret, J., 3, 275-286; 5, 877-886 Liska, D.J., 1, 487-498 Masso-Welch, P., 4, 1109-1119 Kurihara, T., 4, 919-930 Liu, B., 2, 1045-1055 Masucci, M.T., 2, 793-803 Kuriyan, J., 3, 953-957 Liu, F., 5, 989-1001 Masuda, E.S., 5, 119-128 Kurpakus, M.A., 2, 427-438 Liu, T., 3, 1403-1413 Masukata, H., 4, 1121-1132 Kuwabara, P.E., 3, 461-473 Livneh, E., 3, 1049-1056 Matera, A.G., 5, 1289-1299 Kyle, J.W., 1, 197-213 Lizonova, A., 1, 895-905 Matlin, K.S., 1, 921-936 Lloyd, C., 5, 1277-1280 Matsuki, S., 1, 327-335 Lloyd, J.A., 4, 1077-1085 Matsumoto, K., 5, 497-509 Loayza, D., 5, 1185-1198 Matsumoto, T., 4, 337-345 Lafyatis, R., 1, 269-278 Lochrie, M.A., 2, 135-154 Matsuoka, Y., 2, 927-938; 5, 161-172 L'Allemain, G., 2, 675-684 Loeb, J.D.J., 4, 209-222 Matus, A., 5, 511-517 Lalor, P., 1, 27-35 Loeber, C.P., 1, 301-313 Maxfield, F.R., 1, 369-377 Lam, E.W.-F., 5, 1081-1092 Loftus, J.C., 1, 883-893 Mayer-Jaekel, R.E., 3, 287-298 Lam, T.Y., 1, 715-729 Logan, T.J., 5, 667-678 Mayorga, L.S., 1, 113-124 Lamaze, C., 4, 715-727 Lohka, M.J., 5, 713-724 McCaffery, M., 4, 413-424 Lamb, N.J.C., 2, 575-588 Long, C.S., 2, 1081-1095 McCaffrey, T.A., 4, 315-322 Lamb, R.A., 3, 143-155 Longenecker, B.M., 2, 347-355 McCarthy, J.B., 4, 605-613 Langan, T.A., 4, 669-677 Longo, F.M., 1, 189-195 McCormick, F., 5, 173-181 Lange-Carter, C.A., 5, 193-201 Loo, S., 4, 195-208 McCracken, A.A., 4, 729-736 Langer, R., 5, 1281-1288 Loring, G., 5, 763-772 McDougall, A., 3, 373-383 Lark, G., 3, 555-569 Lotz, M.M., 1, 249-257 McEver, R.P., 3, 309-321 Lamer, A.C., 1, 707-713 Louie, K.A., 3, 29-47 McGeoch, J.E.M., 5, 485-496 Larson, R.S., 1, 359-367 Lowenstein, E.J., 4, 1175-1188 McGraw, T.E., 1, 369-377; 4, 1251-1266 Larsson, E., 1, 577-584 Luckey, C., 4, 1351-1359 McGrew, J.T., 3, 1443-1454 La Thangue, N.B., 4, 389-396; Ludin, B., 5, 511-517 McKinnon, C.A., 1, 605-614 5, 1081-1092 Luduefia, R.F., 4, 445-457 McLean, N., 5, 349-361 Lau, A.F., 3, 865-874; 4, 837-848 Lugo, T.G., 5, 597-609 McMahon, A.P., 4, 1267-1275 Lawler, J., 5, 423-437 Lyman, S.D., 3, 197-209 McMahon, J.A., 4, 1267-1275 Lax, I., 1, 173-188; 2, 337-345 McNamee, H., 1, 989-1002 Lazarow, P.B., 4, 1351-1359 McNeill, H., 1, 843-852 Lazzarino, D.A., 5, 807-818 McNew, J.A., 4, 223-232 Le Bivic, A., 5, 1093-1103 Ma, G.-P., 1, 661-674 Mead, J.E., 2, 535-548 Lecocq, J.-P., 3, 95-102 Macchi, M.J., 3, 677-686 Medh, J.D., 5, 227-235 Ledbetter, J.A., 4, 523-530 Macdonald, S.G., 5, 173-181 Medrano, E.E., 5, 497-509 Lee, H.C., 1, 279-290; 2, 203-209 MacGregor, R.R., 5, 725-737 Mehlman, T., 2, 87-93 Lee, K., 3, 1295-1307 Machamer, C.E., 4, 695-704 Mehta, P.P., 3, 839-850 Lee, M.S., 3, 73-84; 5, 989-1001 Machen, T.E., 1, 259-268; 2, 727-737 Meinkoth, J.L., 4, 993-1002

Vol. 5, December 1994 1357 Author Index

Melancon, P., 5, 237-252 Muto, A., 4, 983-992 Oka, J.A., 5, 227-235 Melchior, F., 4, 569-581 Myers, C.A., 3, 699-709 Okaichi, K., 3, 735-747 Meldolesi, J., 3, 1067-1072 Mymryk, J.S., 3, 1107-1115 Okamura, H.H., 3, 429-444; 4, 1145-1159 Meller, V., 1, 771-780 Okano, Y., 1, 747-761 Mellow, T., 1, 471-486 Okazaki, T., 4, 1121-1132 Meloche, S., 3, 63-71 Okishio, N., 4, 1003-1015 Mendel, J.E., 2, 135-154 Nabi, I.R., 4, 627-635 Okkema, P.G., 3, 461-473 Menold, M.M., 5, 529-538 Nachmias, V.T., 3, 1015-1024 Okochi, H., 4, 637-645 Menter, D.G., 4, 1205-1216 Nagafuchi, A., 1, 37-44 O'Lague, P.H., 4, 353-361 Mercurio, A.M., 1, 249-257; 5, 679-690 Nagamine, Y., 2, 491-502 Olashaw, N.E., 3, 1131-1139 Meredith, J.E., Jr., 4, 953-961 Naito, Y., 5, 119-128 Oliver, J.M., 2, 627-640 Meyer, D.I., 5, 1301-1310 Nakajima, M., 4, 1205-1216 Olivier, P., 4, 1175-1188 Michaelis, S., 5, 1185-1198 Nakano, A., 5, 1129-1143 Ondrias, K., 4, 347-352 Miesenbock, G., 5, 1093-1103 Nakata, T., 3, 1181-1194 Onrust, R., 3, 953-957 Miettinen, H.M., 5, 1325-1339 Narayanan, R., 1, 347-357, 863-872 Orlofsky, A., 2, 403-412 Miller, K.R., 3, 959-960 Nasmyth, K., 3, 805-818 Ormondroyd, E., 5, 1081-1092 Mills, A., 2, 767-779 Nathanson, M.H., 3, 113-121 Orr, S.L., 3, 761-773 Milne, J.L., 4, 283-292 Neer, E.J., 1, 125-134 Osborne, M.P., 1, 863-872 Minna, J.D., 3, 613-619 Negulescu, P.A., 1, 259-268 Ostman, A., 2, 503-512 Minor, J.E., 4, 375-387 Neilson, E.G., 2, 219-227 O'Toole, T.E., 1, 883-893 Mirkovitch, J., 3, 1085-1094 Neiman, A.M., 1, 391-401; 4, 107-120 Ouellette, A.J., 2, 251-260 Mishima, Y., 3, 197-209 Neiman, P.E., 5, 763-772 Ozawa, K., 5, 475-484 Miskimins, W.K., 1, 151-164 Nesbitt, J.E., 3, 103-112 Mitchell, E.J., 3, 1295-1307 Neumann, J.C., 4, 1077-1085 Mitcheson, T.G.M., 3, 275-286 Newberry, E.P., 5, 739-746 Mitchison, T.J., 3, 1155-1167, 1309-1315; Newlon, C.S., 3, 999-1013 Paccaud, J.-P., 2, 41-55 5, 217-226 Newport. J., 5, 273-282 Pages, G., 3, 63-71 Miyagawa, K., 1, 327-335 Ng, C., 2, 337-345 Pai, J.-K., 2, 897-903 Miyajima, A., 4, 983-992 Ng, D.T.W., 3, 143-155 Palade, G.E., 4, 413-424 Miyake, S., 4, 1003-1015 Ngan, V.K., 5, 747-761 Palfrey, H.C., 2, 229-239 Miyasaka, M., 2, 979-987 Ngsee, J.K., 4, 747-756 Papadopoulos-Sergiou, A., 3, 1169-1180; Miyazono, K., 1, 327-335, 577-584 Nicolson, G.L., 4, 1205-1216 5, 565-574 Mizuguchi, J., 2, 979-987 Nigg, E.A., 3, 775-787 Papkoff, J., 4, 1267-1275 Mizzen, L.A., 2, 165-179 Nishikawa, S., 5, 1129-1143 Paravicini, G., 3, 415-427 Mobley, W.C., 1, 189-195 Nishimoto, T., 2, 781-792; 3, 1373-1388 Parham, P., 4, 647-660 Mochly-Rosen, D., 1, 693-706 Nishitani, H., 3, 1373-1388 Park, H., 4, 145-157 Moens, G., 1, 1003-1014 Nishiyama, A., 4, 1097-1108 Park, H.-Y., 5, 497-509 Moghadam, M., 5, 839-849 Nishizawa, K., 5, 161-172 Park, J.E., 4, 1317-1326 Mohun, T., 5, 1081-1092 Nishizawa, N., 1, 747-761 Park, L.S., 3, 535-544 Molloy, S.S., 4, 159-172 Nister, M., 2, 651-661 Parker, L.L., 3, 73-84 Moncman, C.L., 4, 1051-1067 Niwa, O., 3, 819-835 Parker, P.J., 2, 491-502; 5, 907-920 Moolenaar, W.H., 1, 615-620 Nocka, K.H., 3, 349-362 Paschal, B.M., 5, 1301-1310 Mooney, D.J., 5, 967-975, 1281-1288 Noda, Y., 3, 1181-1194 Pasquale, E.B., 2, 523-534 Moore, H.-P.H., 1, 415-424 Nojima, H., 2, 819-826 Pastan, I., 3, 507-520 Moran, E., 3, 655-665 Nolan, C.M., 1, 197-213 Patel, R., 2, 391-402 Moreton, R.B., 1, 75-86 Nomoto, H., 1, 747-761 Patton, B.L., 4, 159-172 Morgan, D.O., 3, 571-582 Nomura, N., 1, 347-357 Paul, D.L., 1, 989-1002; 3, 711-720; Morielli, A.D., 5, 485-496 Norberg, L., 1, 577-584 4, 7-20; 5, 363-373 Morris, A.P., 1, 951-963 Nordlund, J.J., 5, 497-509 Paulovich, A., 4, 565-568 Morrissey, J.H., 3, 309-321 Nowlen, J.K., 5, 413-421 Paulsson, M., 5, 203-215 Mostov, K., 3, 1317-1328 Nozawa, Y., 1, 747-761 Pavirani, A., 3, 95-102 Mothe, I., 4, 737-746 Nur-E-Kamal, M.S.A., 3, 1437-1442 Pawson, T., 4, 1175-1188 Muldoon, L.L., 1, 379-390 Nurse, P., 5, 613-616 Pedersen, N., 2, 793-803 Mulero, J.J., 4, 1327-1335 Nye, S.H., 3, 677-686 Pelech, S.L., 3, 775-787 Mulholland, J., 3, 789-803; 4, 1307-1316 Pelletier, A.J., 3, 989-998 Mumby, M.C., 2, 589-598 Peloquin, J.G., 2, 861-874 Mumby, S.M., 3, 49-61 Peng, C.-Y., 5, 989-1001 Munioz, E., 1, 425-434 O'Brien, J.M., 4, 1307-1316 Penkala, J.E., 5, 135-145 Munoz, E.F., 2, 467-477 Obuse, C., 4, 1121-1132 Perkins, S.L., 1, 403-413 Munioz, J., 1, 425-434 Ochs, R.L., 5, 955-966 Perruzzi, C.A., 3, 1169-1180; 5, 565-574 Muntz, K.H., 3, 49-61 O'Connor-McCourt, M.D., 3, 1295-1307 Pessin, M.S., 2, 383-390 Murakami, S., 3, 819-835 O'Donnell, M., 3, 953-957 Peter, M., 3, 775-787 Murawsky, M.M., 1, 683-691 Ogg, S., 3, 73-84 Petersen, R.B., 1, 135-149 Muresan, Z., 5, 725-737 Ogg, S.C., 3, 895-911 Petropoulos, A.C., 2, 27-39 Murphy, C., 3, 249-261; 5, 633-644, O'Hara, B., 4, 135-144 Pfahl, M., 2, 565-574 1119-1127 Ohkura, H., 3, 287-298; 4, 303-313 Pfeffer, S.R., 4, 425-434 Murphy, D.B., 4, 323-335 Ohmichi, M., 2, 691-697 Pfeiffer, J.R., 2, 627-640 Murphy-Ullrich, J.E., 3, 181-188 Ohtsubo, M., 2, 781-792 Pham, D.V., 4, 963-972 Murrell, R.D., 2, 13-25 Ohya, Y., 4, 1017-1025 Piao, Y.-F., 1, 327-335

1358 Molecular Biology of the Cell Author Index

Picard, A., 4, 1295-1306 Rasmussen, U.B., 3, 95-102 Rubin, K., 1, 577-584 Picard, D., 1, 291-299 Rasmusson, K., 5, 45-55 Ruddle, F.H., 1, 151-164 Pickham, K.M., 5, 587-596 Raths, S., 5, 1023-1037 Ruderman, J.V., 4, 781-790 Pierce, M., 5, 519-528 Raymond, C.K., 3, 1389-1402 Ruggeri, Z.M., 1, 883-893 Pierce, S.K., 5, 1265-1275 Read, E.B., 3, 429-444 Ruggieri, R., 5, 173-181 Pike, L.J., 5, 739-746 Reaves, B., 4, 93-105 Rungger-Brandle, E., 5, 1199-1213 Pimpinelli, S., 4, 885-896 Redding, K., 3, 1353-1371 Runyan, R.B., 1, 301-313 Pitt, G.S., 3, 735-747, 1229-1234 Redelmeier, T.E., 4, 715-727 Ruoslahti, E., 1, 731-740 Pittelkow, M.R., 5, 339-347 Regan, J.W., 1, 445-451 Rusnati, M., 2, 719-726 Piwnica-Worms, H., 1, 989-1002; 3, 73-84; Reichardt, L.F., 5, 549-563 Russ, G., 2, 549-563 5, 989-1001 Reijo, R.A., 5, 29-43 Russell, M., 4, 757-765 Pledger, W.J., 3, 1131-1139; 4, 1133-1144 Reisberg, T., 2, 1057-1065 Russell, P., 3, 1373-1388 Plow, E.F., 1, 883-893 Reiss, R., 1, 621-636 Ryan, K., 4, 695-704 Pollard, T.D., 1, 937-950; 3, 1015-1024 Ren, Y.-L., 4, 871-884 Ryan, K.R., 5, 529-538 Pon, L.A., 5, 807-818 Resink, T.J., 1, 649-659 Ponce, E., 4, 1077-1085 Resink, T.J., 1, 821-831 Ponnambalam, S., 4, 583-592 Reyes, A.A., 1, 567-576 Safer, D., 3, 1015-1024 Poon, R., 3, 1279-1294 Rhee, S.G., 5, 17-27 Saint, R., 4, 1161-1174 Poritz, M.A., 3, 895-911 Riabowol, K.T., 3, 323-333 Saito, T., 5, 161-172 Posada, J., 3, 583-592 Rice, G.E., 2, 347-355 Saitoh, I., 4, 1003-1015 Possan, T., 2, 41-55 Rice, R.H., 4, 185-194 Saksela, O., 2, 285-297 Potter, B.V.L., 1, 675-681 Riches, D.W.H., 3, 335-347 Sakurai, S., 1, 771-780 Potts, J.D., 1, 301-313 Richler, C., 5, 1341-1352 Salmon, E.D., 4, 1035-1050 Potvin, B., 2, 989-1000 Riederer, M.A., 4, 425-434 Salser, S., 3, 1155-1167 Pouyssegur, J., 1, 445-451; 2, 675-684; Riezman, H., 4, 511-521; 5, 1023-1037 Saltiel, A.R., 2, 691-697 3, 63-71, 95-102 Rifkin, D.B., 2, 87-93, 699-708; Samejima, I., 4, 1003-1015 Powell, J., 1, 649-659 3, 1057-1065; 4, 973-982 Samuels, H.H., 1, 965-973 Powell, J.S., 1, 821-831 Riggs, M., 1, 763-769; 2, 453-465; Sanders, R., 4, 871-884 Powell-Coffman, J.A., 5, 7-16 3, 167-180, 721-734 Sanderson, M.J., 1, 585-596 Prats, H., 2, 709-718; 4, 1239-1250 Rindt, H., 4, 1051-1067 Sanderson, R.D., 1, 27-35 Presta, M., 2, 719-726; 4, 973-982 Rine, J., 5, 655-665 Sando, G.N., 1, 661-674 Preston, S.F., 2, 915-925 Rizzolo, L.J., 2, 939-949 Sanes, J.R., 1, 731-740 Preuss, D., 3, 789-803; 4, 1307-1316 Robbins, D.J., 2, 965-978; 3, 299-308 Sanghera, J.S., 3, 775-787 Pribnow, D., 1, 379-390 Robbins, J., 4, 1051-1067 Sano, K., 2, 261-270 Pringle, J.R., 4, 1017-1025 Roberts, A.B., 1, 269-278, 875-882; Santoro, S.A., 2, 905-913 Proulx, G., 1, 471-486 2, 241-249, 467-477, 535-548 Sanzo, K.T., 3, 699-709 Prusiner, S.B., 3, 851-863 Roberts, J.M., 3, 389-401 Sasaki, N., 1, 327-335 Pruss, R.M., 1, 683-691 Roberts, M.R., 1, 151-164 Satoh, H., 4, 1121-1132 Prystowsky, M.B., 2, 403-412 Robinson, K.R., 1, 543-554 Sato-Yoshitake, R., 3, 1181-1194 Pukac, L.A., 1, 435-443 Rodgers, L., 1, 763-769; 2, 453-465; Satr6stegui, J., 3, 235-248 Pupillo, M., 3, 1229-1234 3, 167-180, 721-734 Satterberg, B., 4, 495-510 Pytowski, B., 4, 1251-1266 Rodland, K.D., 1, 379-390 Savagner, P., 5, 851-862 Rodriguez, L., 5, 773-783 Sawin, K.E., 5, 217-226 Rodriguez-Boulan, E., 4, 627-635; Schaap, P., 3, 603-612; 5, 703-711 5, 1093-1103 Schadlow, V.C., 3, 941-951 Qadota, H., 4, 1017-1025 Rogers, M.B., 3, 189-196 Schatz, G., 5, 465-474 Qian, S.W., 2, 241-249 Rohrer, J., 4, 511-521 Schekman, R., 3, 129-142, 667-676; Qin, Q., 4, 185-194 Rohrschneider, L., 5, 81-95 4, 931-939 Qiu, Y., 5, 1265-1275 Rohrschneider, L.R., 3, 535-544 Scheller, R.H., 4, 747-756 Quaranta, V., 2, 427-438 Rollier, A., 4, 59-69 Schieven, G.L., 4, 523-530 Quarto, N., 2, 87-93, 699-708 Rolls, M., 4, 695-704 Schlegel, R., 4, 185-194 Quax, P.H.A., 2, 793-803 Romanin, C., 3, 451-460 Schlessinger, J., 1, 173-188, 615-620; Romer, L.H., 5, 349-361 2, 337-345, 641-649; 4, 1175-1188 Romero, G., 4, 483-493 Schmid, S.L., 4, 715-727 Rooney, J.W., 2, 329-335 Schmidhauser, C., 3, 699-709 Raben, D.M., 2, 311-316, 383-390 Rosand, J., 5, 807-818 Schmidt, A., 1, 173-188 Rachie, N.A., 2, 329-335 Rose, B., 3, 839-850 Schmidt, C.J., 1, 125-134 Raeber, A.J., 3, 851-863 Rose, M.D., 4, 1145-1159 Schmidt, L.J., 3, 1073-1083 Ragnotti, G., 2, 719-726 Rosen, V., 3, 189-196 Schoenlein, P.V., 3, 507-520 Rajasekaran, A.K., 5, 1093-1103 Rosenshine, I., 5, 455-464 Schreiber, S., 1, 403-413 Rajavashisth, T., 3, 721-734 Ross, A.H., 1, 605-614; 2, 685-690; Schroer, T.A., 5, 645-654 Ramos, D.M., 2, 805-817 4, 71-78 Schuh, S.M., 5, 739-746 Randall, C.J., 3, 493-505 Ross, C.A., 1, 781-790 Schultz, G., 5, 1-5 Randriamampita, C., 2, 513-522 Rossino, P., 2, 1021-1033 Schultz-Cherry, S., 3, 181-188 Rangan, L.A., 2, 311-316 Rothblatt, J., 3, 129-142 Schulz, M.-F., 2, 767-779 Rankin, M.L., 4, 1189-1204 Rothblum, L.I., 5, 955-966 Schwartz, M.A., 4, 953-961; 5, 389-393 Rapiejko, P.J., 5, 887-897 Rouault, T.A., 4, 1-5 Schwarz, R., 2, 739-752 Rasmussen, C., 5, 785-795 Rouge, M., 1, 821-831 Schwarzbauer, J.E., 4, 941-952 Rasmussen, G., 5, 785-795 Rubin, C.S., 3, 1215-1228 Scidmore, M.A., 4, 1145-1159

Vol. 5, December 1994 1359 Author Index

Scott, R.H., 3, 1415-1425 Sommer, J.M., 3, 749-759 Sykes, K., 4, 223-232 Scott-Burden, T., 1, 649-659, 821-831 Sonnenberg, A., 5, 203-215 Symington, B.E., 1, 637-648 Sebastian, B., 5, 273-282 Spector, A.A., 1, 13-25 Sedbrook, J.C., 5, 1065-1080 Spector, D.L., 3, 555-569; 5, 955-966 Segev, N., 3, 789-803 Spencer, C.S., 4, 941-952 Segre, J., 2, 337-345 Sperling, J., 5, 1341-1352 Segura-Valdez, M. de L., 5, 955-966 Sperling, R., 5, 1341-1352 Taagepera, S., 5, 1243-1251 Sehgal, I., 5, 339-347 Spinardi, L., 4, 871-884 Tadenuma, H., 4, 1027-1034 Seki, T., 3, 1373-1388 Sporn, M.B., 1, 87-97, 269-278, 875-882; Taichman, D.B., 2, 347-355 Senger, D.R., 3, 211-220, 1169-1180; 2, 241-249, 467-477 Takagi, T., 3, 1373-1388 5, 565-574 Sprague, G.F., Jr., 2, 781-792; 4, 107-120 Takahashi, K., 3, 819-835; 5, 1145-1158 Serban, D., 3, 851-863 Spring, J., 2, 927-938 Takaku, F., 1, 327-335 Serr, M., 5, 45-55 Springer, T.A., 1, 359-367; 3, 157-166 Takeichi, M., 1, 37-44; 4, 37-47 Seshadri, T., 1, 215-226 Spudich, J.A., 1, 1-11, 55-63; 3, 1455- Takeuchi, M., 2, 979-987; 4, 247-260 Settleman, J., 4, 1217-1223 1462; 4, 233-246 Talarico, D., 2, 699-708 Seuwen, K., 1, 445-451 Squinto, S.P., 3, 677-686 Tanaka, E., 1, 747-761 Sha'afi, R.I., 2, 915-925 Staatz, W.D., 2, 905-913 Tanaka, N., 5, 899-905 Shackelford, D.A., 2, 73-85 Staedel, C., 2, 65-72 Tang, P., 5, 455-464 Shah, V., 5, 497-509 Stahl, P.D., 1, 113-124, 403-413 Tang, W.-J.Y., 5, 57-70 Shalloway, D., 5, 413-421 Stallcup, M.R., 1, 531-541 Tanihara, H., 2, 261-270 Shapiro, L., 3, 913-926 Stallcup, W.B., 4, 1097-1108 Tansley, F., 2, 383-390 Sharma, R.V., 1, 301-313 Stanley, P., 2, 989-1000 Tapiovaara, H., 2, 1057-1065 Shattil, S.J., 1, 883-893 Staub, O., 5, 1301-1310 Taraboulos, A., 3, 851-863 Shaw, L.M., 5, 679-690 Stauderman, K.A., 1, 683-691 Tarone, G., 2, 1021-1033 Shea, T.B., 5, 863-875 Steinhardt, R.A., 4, 963-972; 5, 1159-1167 Tartakoff, A.M., 5, 1253-1263 Sheffield, L.G., 4, 773-780 Steinmann, K.E., 4, 185-194 Tartare, S., 4, 737-746 Sheldrick, K.S., 5, 147-160 Steitz, J.A., 5, 1289-1299 Tashjian, A.H., Jr., 2, 889-896 Shen, D.-w., 3, 507-520 Stendahl, O., 2, 41-55 Tavtigian, S.V., 5, 375-388 Shen, J., 4, 1109-1119 Stenson, W.F., 1, 403-413 Taylor, D.L., 3, 1037-1048; 4, 819-836 Shibuya, E.K., 4, 781-790 Stephens, R.W., 1, 895-905; 2, 1057-1065 Taylor, N., 4, 185-194 Shibuya, K., 1, 327-335 Stem, M.J., 4, 1175-1188 Taylor, S.J., 5, 413-421 Shih, F.F., 1, 907-919 Stemnberg, P.W., 2, 135-154; 5, 395-411 Taylor, S.S., 4, 993-1002 Shilling, F., 1, 465-469 Sternweis, P.C., 3, 49-61 Taylor, T.C., 5, 237-252 Shimanuki, M., 3, 263-273; 4, 303-313 Stevens, K., 4, 59-69 Teitelbaum, S.L., 1, 403-413 Shuttleworth, J., 5, 921-932 Stevens, T.H., 3, 1389-1402; 5, 1039-1050 Teixido, J., 2, 347-355 Sibley, C.H., 2, 329-335 Stevenson, B.J., 4, 107-120 Telang, N.T., 1, 863-872 Silengo, L., 2, 1021-1033 Stewart, E., 3, 1279-1294 Tempst, P., 2, 211-218 Silva, S., 4, 435-443 Stewart, S.J., 2, 841-850 Terhorst, C., 1, 907-919; 2, 753-765 Silver, P., 3, 875-893; 4, 919-930 Stirling, C.J., 3, 129-142; 5, 773-783 Theologis, A., 4, 363-373 Sim, S.S., 5, 17-27 Stith, B.J., 4, 435-443 Thiery, J.P., 1, 975-988, 1003-1014; Simanis, V., 4, 531-539 Stitt, T.N., 3, 677-686 5, 851-862 Simon, M.I., 2, 135-154; 4, 469-482 Stoflet, E.S., 3, 1073-1083 Thomas, H.A., 2, 727-737 Simpson, K., 5, 1177-1184 Stoll, L.L., 1, 13-25 Thomas, S.J., 5, 763-772 Simpson, P.C., 1, 693-706; 2, 1081-1095 Stoyanovsky, D.A., 4, 347-352 Thorbum, A.M., 4, 705-713 Singer, S.J., 3, 385-388 Stratmann, R., 4, 1161-1174 Thomer, J., 5, 283-296 Sitia, R., 3, 1067-1072; 5, 1311-1324 Strauch, A.R., 3, 1073-1083 Thorsness, M.K., 5, 655-665 Siu, C.-H., 1, 715-729 Street, A.J., 5, 597-609 Thorsness, P.E., 5, 899-905 Sizeland, A.M., 3, 1235-1243 Stringham, E.G., 3, 221-233 Tiberio, L., 2, 719-726 Skibbens, R.V., 4, 1035-1050 Strumwasser, F., 2, 193-202, 211-218 Tienari, J., 2, 285-297 Skorecki, K., 2, 641-649 Strupp, J.A., 2, 841-850 Tilley, C., 2, 739-752 Skurat, R.M., 2, 889-896 Stukenberg, P.T., 3, 953-957 Timar, J., 2, 1045-1055 Slack, J.L., 1, 487-498 Sturgill, T.W., 4, 483-493; 5, 1243-1251 Timpl, R., 2, 805-817; 5, 203-215 Slakey, L.L., 3, 493-505 Styles, C.A., 5, 1003-1022 Titorenko, V.I., 5, 829-837 Sly, W.S., 1, 197-213 Subjeck, J.R., 4, 1109-1119 Titus, M.A., 1, 55-63; 4, 233-246 Smilenov, L., 5, 1215-1223 Subramaniam, M., 4, 791-801 Tobias, S., 3, 1195-1197 Smith, H.S., 2, 875-888 Suidan, H.S., 2, 13-25 Toda, T., 3, 263-273; 4, 303-313, Smith, L.C., 3, 403-414 Sukhatme, V.P., 2, 251-260 1003-1015 Smith, L.D., 1, 543-554 Sullivan, W., 4, 885-896 Tojo, A., 1, 327-335 Smith, M.G., 5, 807-818 Sun, L., 3, 1095-1105 Tokumitsu, H., 5, 119-128 Smith, R.M., 2, 1097-1113 Sun, S.-C., 3, 1339-1352 Tolkovsky, A.M., 2, 13-25 Smith, V.L., 1, 165-172 Supattapone, S., 1, 781-790 Tombes, R.M., 2, 861-874 Smolich, B.D., 4, 1267-1275 Surana, U., 3, 805-818 Tomic, M., 1, 965-973 Snyder, M., 3, 1025-1035; 1259-1267 Suzuki, S., 2, 261-270 Trager, J.B., 5, 283-296 Snyder, S.H., 1, 781-790; 3, 621-631 Swann, K., 3, 373-383, 1415-1425 Trautmann, A., 2, 513-522 Soede, R.D.M., 5, 703-711 Swenson, K.I., 1, 989-1002 Tremble, P., 5, 439-453 Soldati, T., 4, 425-434 Sweterlitsch, L.A., 1, 863-872 Trevithick, J.E., 1, 597-604; 2, 951-964 Soll, D., 4, 233-246 Swezey, R.R., 1, 65-74 Trinczek, B., 4, 323-335 Solomon, M.J., 3, 13-27; 4, 79-92 Swift, A.M., 4, 695-704 Tronche, F., 4, 59-69

1360 Molecular Biology of the Cell Author Index

Trowbridge, I.S., 2, 73-85 Wachsstock, D., 3, 1015-1024 Wilcox, C.A., 3, 1353-1371 Tsien, R.Y., 1, 259-268; 4, 993-1002 Wachter, C., 5, 465-474 Wileman, T., 1, 907-919; 2, 753-765 Tsuboi, A., 5, 119-128 Waddle, J.A., 4, 907-917 Wiley, H.S., 5, 539-547 Tsvetkov, A., 3, 249-261 Waeber, C., 3, 961-969 Williams, C.L., 2, 373-381 Tucker, G.C., 1, 975-988 Wagner, D.D., 4, 791-801 Williams, D.E., 3, 197-209 Turck, C., 5, 323-338 Wagner, M., 5, 1093-1103 Williams, J.G., 3, 1403-1413 Turksen, K., 2, 613-625 Wagner, P., 5, 105-118 Williams, M.A., 1, 543-554 Turner, C.E., 5, 349-361 Wahl, M., 4, 293-302 Wills, K.N., 2, 565-574 Tycowski, K.T., 5, 1289-1299 Wahrman, J., 5, 1341-1352 Wilner, G.D., 1, 453-463 Tye, B.-K., 3, 971-980 Waleh, N., 2, 805-817 Wilson, L.K., 5, 283-296 Tzou, P., 5, 395-411 Walker, D.H., 3, 687-698, 927-939 Winkelmann, D.A., 4, 1051-1067 Tzukerman, M., 2, 565-574 Walsh, J.J., 2, 905-913 Winston, J.T., 4, 1133-1144 Walter, G., 2, 589-598 Witte, O.N., 5, 597-609 Walter, P., 2, 851-859; 3, 895-911 Wohlgemuth, J.G., 5, 839-849 Walton, P.A., 4, 705-713 Wold, B.J., 5, 375-388 Wang, C.C., 3, 749-759 Wolf, D.E., 1, 605-614 Uckun, F.M., 4, 523-530 Wang, H.-C.R., 3, 1329-1337 Wolf, G., 2, 219-227 Uhlinger, D.J., 4, 261-269 Wang, J., 2, 819-826 Wollheim, C.B., 5, 1199-1213 Ullrich, A., 1, 173-188; 2, 337-345, Wang, M., 3, 603-612 Wong, D.H., 4, 647-660 641-649 Wang, P.-C., 3, 275-286 Wong, W.-L., 4, 121-133 Unanue, E.R., 1, 499-509 Wang, T.S.-F., 4, 145-157 Woo, D.D.L., 1, 511-521 Underwood, G.A., 3, 335-347 Wang, Y., 1, 763-769; 2, 453-465; Woodman, P.G., 4, 541-553; 5, 773-783 Unwin, N., 3, 1155-1167 5, 819-828 Woods, A., 4, 605-613; 5, 183-192 Ursic, D., 5, 1065-1080 Ward, D.C., 5, 1289-1299 Woolkalis, M.J., 2, 1097-1113 Usuki, K., 1, 577-584 Ward, S., 5, 129-134 Worthylake, R., 5, 539-547 Uyeda, T.Q.P., 3, 1455-1462 Warren, G., 4, 541-553; 5, 519-528, Wozney, J.M., 3, 189-196 907-920 Wright, R., 3, 1353-1371 Warrick, H.M., 1, 55-63 Wright, S., 4, 661-668 Wartmann, M., 2, 491-502 Wright, T.C., Jr., 1, 435-443 Wasserman, S.A., 4, 767-771 Wright, T.M., 2, 311-316 Vacanti, J.P., 5, 967-975, 1281-1288 Watanabe, H., 1, 197-213 Wu, C.-H.H., 5, 633-644 Vaheri, A., 1, 895-905; 2, 1057-1065 Watanabe, S., 4, 983-992 Wu, J., 2, 535-548 Vaillancourt, R.R., 5, 193-201 Waterston, R.H., 4, 907-917 Wu, J., 4, 483-493 Valetti, C., 5, 1311-1324 Watowich, S.S., 3, 143-155 Wu, L., 5, 691-702 Valkema, R., 5, 575-585 Watson, R., 4, 583-592, 1069-1076 Wu, Z., 3, 249-261; 5, 633-644, 1119-1127 Vallee, R.B., 5, 1301-1310 Weber, K., 4, 569-581 Valles, A.M., 1, 975-988; 5, 851-862 Weber, M.J., 2, 675-684 Vancura, A., 3, 275-286 Weening-Verhoeff, E.J.D., 2, 793-803 van Daal, A., 3, 593-602 Wei, N., 4, 79-92 van der Klei, I.J., 5, 829-837 Wei, Y.-P., 1, 661-674 van der Velden, H.M.W., 5, 713-724 Weidman, P., 5, 237-252 Xing, Z., 5, 413-421 Van De Water, L., 3, 211-220, 1169-1180; Weigel, P.H., 5, 227-235 Xiong, Y., 4, 897-906 5, 565-574 Weinman, J., 2, 819-826 Xu, H.-P., 1, 763-769; 3, 721-734; Van Haastert, P.J.M., 3, 603-612; Weinman, S., 2, 819-826 4, 107-120 5, 575-585 Weiss, M.C., 4, 59-69 Xu, M., 3, 73-84 Van Obberghen, E., 2, 317-327; 4, 737-746 Welch, M.D., 5, 617-632 Xu, X., 4, 261-269; 5, 1265-1275 Van Obberghen-Schilling, E., 3, 95-102 Welch, W.J., 2, 165-179 Xu, Z., 1, 1057-1067 van Zeijl, M.J.A.H., 1, 921-936 Wells, M.A., 5, 129-134 Varmus, H., 5, 267-272 Welsh, J.B., 5, 539-547 Varmus, H.E., 3, 521-533 Wen, W., 4, 993-1002 Varrault, A., 3, 961-969 Werb, Z., 5, 439-453 Vater, C.A., 3, 1389-1402 Wemstedt, C., 1, 577-584 Veenhuis, M., 5, 829-837 Wertman, K.F., 4, 1277-1294 Yamada, H., 5, 1145-1158 Venkatakrishnan, G., 1, 605-614 Weskamp, G., 5, 549-563 Yamada, K., 5, 475-484 Verheijden, G.F., 1, 615-620 Wessels, D., 4, 233-246 Yamada, K.M., 5, 851-862 Verheijen, J.H., 2, 793-803 Westermark, B., 1, 555-566; 2, 503-512, Yamamoto, K.R., 1, 291-299; 3, 1245-1257 Verlaan, I., 1, 615-620 651-661 Yamamoto, M., 3, 839-850 Verma, A., 1, 781-790; 3, 621-631 Yamamoto, T., 2, 979-987 Verma, D., 1, 781-790 Wetts, R., 3, 323-333 Yamanashi, Y., 2, 979-987 Verrey, F., 1, 471-486 Whalley, T., 2, 121-133; 3, 373-383 Yamashita, K., 3, 1373-1388 Villereal, M.L., 2, 229-239 Whitaker, M., 2, 121-133, 391-402; Yanagida, M., 3, 263-273, 819-835; 4, 247- Vincent, L.A., 4, 483-493 3, 373-383 260, 303-313, 1003-1015; 5, 1145-1 158 Vlodavsky, I., 1, 453-463, 833-842 White, D., 5, 1051-1063 Yancopoulos, G.D., 3, 677-686 Volberg, T., 2, 105-120 White, K.H., 5, 899-905 Yang, C.H., 3, 1259-1267 Volonte, C., 3, 363-371; 4, 71-78 White, T.W., 3, 711-720; 5, 363-373 Yang, F., 5, 497-509 Vouret-Craviari, V., 3, 95-102 Whittaker, K., 4, 353-361 Yang, J., 4, 803-817 Vu, M.P., 2, 805-817 Wigler, M., 1, 763-769; 2, 155-164, 453- Yarden, Y., 3, 197-209 Vu, T.-K.H., 1, 189-195 465; 3, 167-180, 721-734; 4, 107-120 Yerram, N.R., 1, 13-25

Vol. 5, December 1994 1361 Author Index

Yewdell, J.W., 2, 549-563 Zabludoff, S.D., 5, 375-388 Zhang, M., 1, 511-521 Yokota, T., 4, 983-992 Zaheer, A., 1, 741-746 Zhang, X., 2, 565-574 Yook, K.J., 4, 885-896 Zakut, R., 3, 197-209 Zhong, W., 1, 741-746 Yoon, H.-J., 4, 195-208 Zamanian, M., 4, 389-396 Yorek, M.A., 1, 13-25 Zanibellato, C., 4, 1239-1250 Zhou, K., 5, 691-702 Yoshida, T., 4, 303-313 Zanolari, B., 4, 511-521 Zick, Y., 2, 105-120 Yoshihisa, T., 3, 667-676 Zarembinski, T.I., 4, 363-373 Ziff, E.B., 5, 1225-1241 Yoshimura, K., 4, 931-939 Zaret, K., 4, 59-69 Ziman, M., 4, 1307-1316 Young, D., 2, 155-164; 3, 167-180 Zhang, H., 4, 897-906 Zimmerman, D.L., 2, 851-859 Yuspa, S.H., 1, 87-97 Zhang, J.W., 4, 1351-1359 Zubiaga, A.M., 1, 425-434

1362 Molecular Biology of the Cell Subject Index to Volumes 1-5

A31 cells (BALB/c murine 3T3 fibroblasts) ACTH Adenosine interferon effects on, 1, 215-226 in secretory vesicles, rab proteins effects cyclic AMP production and, 2, 13-25 A375 melanoma cells on, 4, 747-756 receptor for, in actin polymerization, 5, laminin of, integrin binding to, 2, 805- Actin 313-322 817 binding of, in yeast mitochondria, 5, 807- Adenosine diphosphoribose, cyclic A431 cells 818 production of, egg-specific NADase for, epidermal growth factor stimulation of, 2, capping protein of, expression in yeast, 4, 2, 193-202, 2, 203-209, 2, 211-218 827-840 907-917 Adenosine diphosphoribosyl cyclase perforated, coated pit recruitment in, 4, in cytoskeleton characterization of, 2, 203-209, 2, 211- 715-727 organization of, ras-related GTPases in, 218 proliferation of, immunophilin ligands 3, 475-479 Adenosine triphosphate effects on, 3, 981-987 in Saccharomyces cerevisiae, Tcpl in actin binding, in yeast mitochondria, 5, A875 cells (melanoma) protein role in, 5, 1065-1080 807-818 nerve growth factor receptor diffusion in, filaments of, 3, 1309-1315 in crosslinking of IgE receptor with 1, 605-614 in insulin secretion, 5, 1199-1213 membrane skeleton, 2, 181-191 A23187 (calcium ionophore) functional changes in, in Saccharomyces depletion of, in neurons, agonists effects in amphibian egg activation, 1, 315-326 cerevisiae, Ancl protein in, 5, 617- on, 2, 13-25 brain calcium uptake and, 1, 781-790 632 in exocytosis, 1, 337-346, 1, 523-530 c-kit ligand expression and, 3, 349-362 genes of extracellular, in cytosolic calcium fibroblast effects of, 2, 229-239 muscle-specific promoter activation of, regulation, 3, 493-505 in interleukin-4 gene expression, 1, 425- 3, 1073-1083 in guanylyl cyclase activation, 5, 3-4 434 polymerization of, 3, 475-479 hydrolysis of, in recruitment into coated A kinase anchor proteins microtubules of, 3, 1309-1315 pits, 4, 715-727 in neurons, cAMP signaling and, 3, modulation of, in Rous sarcoma virus- in J774 macrophage-like cells, anthrax 1215-1228 modified chick lens cells, 2, 105-120 lethal toxin effects on, 3, 1269-1277 AA861 organization of, in Saccharomyces membrane binding protein for, in protein in HeLa spreading on substrates, 3, 481- cerevisiae, END3 gene in, 5, 1023- transfer across endoplasmic 492 1037 reticulum membrane, 2, 851-859 abm genes phorbol ester effects on, 1, 227-236 mitochondrial protein effects of, 2, 165- in Dictyostelium motion, 1, 55-63 polymerization of, 3, 1309-1315 179 abpl genes genes of, 3, 475-479 in mobilized calcium localization, 3, 613- in Saccharomyces cerevisiae mating nucleotide exchange regulation in, 3, 619 projection formation, 3, 429-444 1015-1024 requirements for, in mitochondrial in yeast, null mutation of, 4, 459-468 in polymorphonuclear neutrophils, 3, protein import, 5, 465-474 Acanthamoeba 1427-1435 Adenosine triphosphate-actin subunits myosins in, 1, 55-63 trigger mechanisms for, 5, 313-322 in actin polymerization, 3, 1015-1024 profilin of, in phospholipase C inhibition, reorganization of, heavy metal ions in, 2, Adenosine-5'-O-(3-thiotriphosphate) 1, 937-950 1067-1079 in phospholipase D activation, 2, 1011- Acetate in Saccharomyces cerevisiae budding, 3, 1019 in exocytosis from mast cells, 1, 337-436 429-444, 4, 1277-1294 Adenoviruses Acetylcholine receptors, muscarinic in yeast cytoskeleton, gene null mutations in cell transformation, small nuclear activation of, small cell lung carcinoma in, 4, 459-468 ribonucleoprotein particle inhibition by, 2, 373-381 Actin-based cytomatrix localization and, 3, 555-569 N-Acetyl-leu-leu-methionine aldehyde stress fibers in, myosin II phosphorylation ElA proteins of, in suppression of as protease inhibitor, in T-cell receptor and, 3, 1037-1048 myoblast differentiation, 3, 1107- chain degradation studies, 2, 753- Actin-based motors 1115 765 in cell movement, 1, 7-9 early response genes of, in N-Acetyl-leu-leu-nleu aldehyde in Dictyostelium, 1, 55-63 pheochromocytoma cell as protease inhibitor, in T-cell receptor Actin-binding protein differentiation, 2, 479-489 753- in 475-479 gene expression in, transcriptional chain degradation studies, 2, cytoskeleton organization, 3, attenuation in, 4, 661-668 765 Actinin transforming growth factor activity and, Acid cholesteryl ester hydrolase (lysosomal characterization of, 1, 166 3, 655-665 acid lipase) modulation of, in Rous sarcoma virus- Adenylyl cyclase in cholesteryl ester metabolism, 1, 661- modified chick lens cells, 2, 105-120 agonists effects on, 2, 13-25 674 Actin-related proteins in Dictyostelium, cAMP receptors in, 3, Acidic fibroblast growth factor. See under f,-centractin as, 5, 1301-1310 1229-1234 Fibroblast growth factor Activator of DNA replication in DNA synthesis, a-adrenergic agonists Acidification induction in lymphocytes, 1, 1015-1025 effects on, 1, 445-451 of endosomes, receptor trafficking and, 4, Activator protein-1 DNA motif inhibition of, 3, 735-747 1251-1266 dual, 3, 941-951 serotoninlA agonists in, 3, 961-969 Aconitase Acyl-CoA oxidase by thrombin receptor peptides, 3, 95- cytosolic, as regulatory RNA binding biogenesis of, in yeasts, 4, 1351-1359 102 protein, 4, 1-5 Adenocarcinoma cells prothoracic gland, regulation of, 1, 771- ACT1 gene vascular permeability factor expression 780 in yeast, null mutation of, 4, 459-468 in, 3, 211-220 of Schizosaccharomyces pombe, 2, 155-164

Adenylyl cyclase-associated protein, cap Affinity modulation Ammonium chloride gene of, characterization of, 3, 167- of integrins, 1, 883-893 proteolysis rate and, 1, 907-919 180 Age factors Amoebas Adenylyl imidodiphosphonate in transforming growth factor-beta cyclic AMP receptors of, in calcium ion in prothoracic gland function, 1, 771-780 response, in vascular smooth muscle influx promotion, 4, 283-292 Adherens-type junctions cells, 4, 315-322 motility of, myoA gene in, 4, 233-246 modulation of, in Rous sarcoma AKAP 150 protein profilin of, in phospholipase C inhibition, transformed cells, 2, 105-120 in neurons, cAMP signaling and, 3, 1, 937-950 Adhesion. See also Cell adhesion molecules; 1215-1228 Amphibian oocytes Integrin(s) Alanine lampbrush chromosome loops of, cell mutations to, in yeast ,B-tubulin gene, 5, transcription on, 3, 249-261 arachidonic acid metabolites in, 3, 481- 29-43 Amphiregulin 492, 4, 271-281 Albumin expression of, epidermal growth factor basic fibroblast growth factor effects gene expression regulation of, receptor-dependent stimulation of, 5, on, 4, 973-982 transcription factors in, 4, 59-69 339-347 cadherins in, 1, 37-44 thrombospondin-transforming growth Anaerobiosis fibronectin-derived synthetic peptide factor binding and, 3, 181-188 in rice plants, 1-aminocyclopropane-1- in, 4, 605-613 Alcohol dehydrogenase carboxylate synthase gene expression integrin receptor focal contact import into mitochondria, ATP and, 4, 363-373 localization and, 4, 593-604 requirements for, 5, 465-474 Ancl protein osteopontin in, 3, 1169-1180 Alcohol oxidase of Saccharyomyces cerevisiae, similarity to regulation of, thrombospondin in, 3, assembly of, in Hansenula polymorpha, human leukemia proteins, 5, 617- 181-188 flavin adenine dinucleotide 632 cell-cell, disruption of, with mutant requirements in, 5, 829-837 Anchorage-independent growth cadherins, 4, 37-47 Aldosterone endothelin-1 in, 1, 379-390 of colon carcinoma cells to laminin, 1, glucocorticoid receptor binding of, 3, Androgens 249-257 1245-1257 in prostate cancer cell stimulation, focal, syndecan 4 heparan sulfate Alkaline phosphatase amphiregulin expression and, 5, proteoglycan in, 5, 183-192 in ADR induction, 1, 1015-1025 339-347 hemidesmosome-like, integrin interaction release by SaOS-2 osteoblasts, 2, 889-896 Aneuploidy with, 4, 871-884 sorting of, in yeast, 3, 415-427 in Schizosaccharomyces pombe of integrin ,B1, 5, 1215-1223 1-O-Alkyl-2-acetyl-sn-glycerol, 1, 13-25 minichromosome loss, 5, 1145-1158 of integrin a2' focal adhesion formation 1-O-Alkyl-2-acetyl-sn-glycero-3- Angiogenesis and, 5, 977-988 phosphocholine (platelet-activating basic fibroblast growth factor modulation of myoblasts with thrombospondin-1, 5, factor) metabolites of, integrin expression in, 4, 973-982 423-437 smooth muscle activity of, 1, 13-25 epidermal growth factor stimulation of, of osteopontin, regulation of, 5, 565-574 N-Allylnormetazocine in glioblastoma multiforme, 4, 121- of tumor cells to endothelium, biologically active binding sites for, on 133, gro gene expression in, 2, 739- arachidonic acid metabolites and, 2, lung cancer cells, 3, 613-619 752 1045-1055 Alpha-factor platelet-derived endothelial cell growth Adhesion plaque protein (talin) yeast cell exposure to, FAR1 factor in, 1, 577-584 phosphorylation of, phorbol ester and, 1, phosphorylation and, 3, 445-450 Angiotensin(s) 227-236 Alpha-granules (platelet) calcium ion changes vs. catecholamine Adhesion plaque-localized integrin, 2, 271- factors affecting secretion from, 1, 1027- release and, 1, 683-691 283 1041 in endothelin-specific transcript ADP-actin subunits Alpha-1-protease inhibitor induction, 1, 649-659 in actin polymerization, 3, 1015-1024 in yeast exocytic pathway protein phosphoinositide hydrolysis and, 1, 615- ADP-ribosyl cyclase degradation study, 4, 729-736 characterization of, 2, 203-209, 2, 211- 620 218 ALR-2B cells Angiotensin II muscle-specific actin gene promoter tubular epithelial cell hypertrophy from, ADP-ribosylation factors activation 1073-1083 in Golgi function, 5, 237-252 in, 3, collagen secretion and, 2, 219-227 heterotrimeric G proteins and, 3, 1317- Aluminum chloride-fluoride complex in vascular smooth muscle cell 1328 in DNA synthesis, 1, 445-451 stimulation, 1, 821-831 ADR (activator of DNA replication) Alveoli-like structures Annexins induction whey acidic protein expression and, 1, calcium affinity of, 1, 166 in lymphocytes, 1, 1015-1025 45-54 identification of, 1, 168 Adrenal gland cells Amino acids, aromatic Anoxia catecholamine release from, calcium in transferrin receptor, 1, 369-377 in rice plants, 1-aminocyclopropane-1- levels in, 1, 683-691 1-Aminocyclopropane- 1 -carboxylate carboxylate synthase gene expression vascular permeability factor expression synthase and, 4, 363-373 in, 3, 211-220 genes encoding, in rice, 4, 363-373 Anthrax lethal toxin a-Adrenergic agonists N-(6-Aminohexyl)-5-chloro-1- effects on J774 macrophage-like cells, 3, DNA synthesis and, 1, 445-451 naphthalenesulfonate (W-7) 1269-1277 a-Adrenergic receptors in amphibian egg activation, 1, 315-326 Antibodies DNA synthesis and, 1, 445-451 2-Aminopurine to protein kinase C, neurite outgrowth AF-9 protein nerve growth factor activity effects of, 3, and, 3, 323-333 implicated in human leukemia, similarity 363-371 to syndecan 4 heparan sulfate to Ancl protein of Saccharyomyces in protein kinase activity inhibition, nerve proteoglycans, in focal adhesion cerevisiae, 5, 617-632 growth factor receptor and, 4, 71-78 studies, 5, 183-192

1364 Molecular Biology of the Cell Subject Index

Anti-CD3 antibody Arginine-vasopressin Autocrine growth factors T-cell stimulation with, phospholipase D in endothelin-specific transcript in carcinoma proliferation inhibition, 3, activity in, 2, 841-850 induction, 1, 649-659 1235-1243 Antigens Arizona, University of Autocrine stimulation monovalent, in crosslinking of IgE Undergraduate Biology Research platelet-derived growth factor in, 1, 561 receptor with membrane skeleton, 2, Program, 5, 129-134 Autonomous replication 181-191 ARS activity of chromosomal DNA fragments, 4, processing of, major histocompatibility in minichromosome propagation, 3, 971- 1121-1132 complex in, 1, 499-509 980 Autophosphorylation tumor, in oncogenic virus cell in Saccharomyces cerevisiae chromosome of extracellular signal-regulated kinases, transformation, 2, 589-598 III circular derivative, 3, 999-1013 3, 299-308, FUS3 mutations Antiparallel microtubules Arterial smooth muscle cells promoting, in yeast mating, 5, 297- microtubule flux independence of, 5, cytosolic calcium regulation in, in 312 217-226 response to extracellular ATP, 3, of insulin receptors, 2, 65-72 Antipeptide antibodies 493-505 of MEK-1 protein kinase, 5, 193-201 in extracellular signal-regulated kinases Arteries of neurotrophin receptors, inhibition of, identification, 2, 357-371 intimal hyperplasia of, age-related 3, 677-686 Antiproliferative activity transforming growth factor-beta of protein kinases of glia maturation factor ,B, 1, 741-746 vs. cell cycle stage, 4, 247-260 response and, 4, 315-322 in hippocampal neurons, 4, 159-172 Antisense oligonucleotide Asialoglycoprotein receptor activity of transforming growth factor-a, of Saccharomyces cerevisiae, cell cycle fatty acyl-coenzyme A regulation of, in and, 4, 195-208 carcinoma cell inhibition by, 3, hepatocytes, 5, 227-235 1235-1243 Avian gro gene Antisense RNA Aspartate expression of, in inflammation, 2, 739- of calmodulin, in Dictyostelium, bacterial chemotactic response to, 752 cytokinesis inhibition by, 3, 1403- computer simulation of, 4, 469-482 Axonemes 1413 in exocytosis from mast cells, 1, 337-346 flagellar, motility inhibition of, by dynein Antiviral activity Aspartic acid residues IC1 peptide monoclonal antibodies, of interferons, 1, 215-226 of collagen, in platelet adhesion/ 5, 1051-1063 Aorta activation, 2, 905-913 5-Azacytidine smooth muscle of, connexin43 in, 4, 7-20 Astrocytes in a(1,3)fucosyltransferase activation, 2, AP-1 growth factor effects on, 1, 511-521 989-1000 binding sites for, in collagenase gene ATCC 1573 cells Azatyrosine expression, 1, 269-278 platelet integrin expression on, spreading in mitogen-activated protein kinase in v-Src protein activity characterization, on fibrinogen, 3, 989-998 activation inhibition, 4, 483-493 5, 1177-1184 Atherosclerosis L-Azetidine-2-carboxylic acid Aplysia californica age-related transforming growth factor- mitochondrial protein effects of, 2, 165- egg-specific NADase of, characterization beta response and, 4, 315-322 179 of, 2, 193-202, 2, 203-209, 2, 211- endothelin in, 1, 649-659 218 lysosomal acid lipase in, 1, 661-674 Apoptosis thrombin involvement in, 1, 453-463 blocking of, extracellular matrix in, 4, ATP. See Adenosine triphosphate 953-961 ATPases B cell(s) in bursa of Fabricius lymphoblasts, cell calcium-pumping, in Golgi function, 3, differentiation of, syndecan in, 1, 27-35 cycle control loss in, 5, 763-772 633-654 nuclear factor kappa B activation in, 2, Aporeceptors in sodium regulation in gastric cells, 1, 329-335 of steroid hormones, nuclear localization 259-268 291-299 syndecan expression in, 5, 797-805 regulation in, 1, subunits of, import into mitochondria, B cell antigen receptor Apyrase ATP requirements for, 5, 465-474 stimulation by lyn gene products, 2, 979- in cyclic adenosine diphosphate-ribose Atrial natriuretic peptide 987 action, 1, 279-290 as guanylyl cyclase ligand, 5, 1-5 mitochondrial protein effects of, 2, 165- B28 cell line 179 Atrioventricular canal collagen binding to, NG2 proteoglycan Arachidonic acid embryonic development of, signal and, 4, 1097-1108 metabolism of, IgE receptor crosslinking transduction in, 1, 301-313 B52 protein, Drosophila, distribution within in, 2, 181-191 Atropine chromosomal locus, 5, 71-79 metabolites of cyclic AMP production and, 2, 13-25 B snurposomes in cell spreading, 4, 271-281 muscarinic acetylcholine receptor transcription in, small nuclear RNA cyclic AMP production and, 2, 13-25 activation and, 2, 373-381 effects on, 3, 249-261 in HeLa cell spreading on substrates, 3, AtT-20 cells Bacillus anthracis lethal toxin 481-492 P-selectin transfection of, sorting into effects on J774 macrophage-like cells, 3, in tumor cell adhesion modulation, 2, regulated secretion pathway and, 3, 1269-1277 1045-1055 309-321 Bacteria mobilization of, neurokinin receptors in, secretory granule localization in, rab chemotaxis of, phosphorylation cascade 2, 767-779 proteins in, 4, 747-756 in, computer simulation of, 4, 469- release of, protein kinase C**sub gamma selectin distribution in, 4, 791-801, Wnt 482 effects on, 5, 475-484 gene family in, 4, 1267-1275 GroEL proteins of, interactions with Arginine residues AUG translational start codons mitochondrial proteins, 2, 165-179 of basic fibroblast growth factor, in basic fibroblast growth factor Bafilomycin Al methylation of, 2, 87-93 oncogenicity, 2, 709-718 in receptor trafficking, 4, 1251-1266

Vol. 5, December 1994 1365 Subject Index

Balb fibroblasts endoplasmic reticulum-to-Golgi Brain cyclin D mRNA expression in, growth transport, 5, 1119-1127 cadherins in, 2, 261-270 factor regulation of, 4, 1133-1144 Binding protein bodies calcium ion distribution in, 1, 781-790 BALB/c-3T3 cells formation of, 5, 1119-1127 calmodulin gene expression regulation in, interferon effects on, 1, 215-226 Biology education, 3, 959-960 2, 819-826 nuclear factor kappa B-like activity Biotinylated proteins extracellular signal-regulated kinases in, induced in, 3, 1131-1139 binding to fibronectin, 2, 927-938 2, 357-371 vinculin gene expression in, 1, 621-636 2',7'-Bis-(2-carboxyethyl)-5(and - microtubules of, dynamics of, 4, 323-335 Balbiani rings, Drosophila B52 protein 6)carboxyfluorescein rat distribution on, 5, 71-79 in parietal cell chloride/bicarbonate drug bindings sites on, 3, 613-619 BALB-3T3 cells exchange studies, 2, 727-737 A kinase anchor protein distribution in, mitogen effects on, 1, 747-761 1,2-Bis(o-aminophenoxy)ethane-N,N,N',N'- 3, 1215-1228 BAPTA (1,2 bis(2-aminophenoxy)ethane tetraacetic acid scrapie prion degradation in, 3, 851-863 N',N',N',N'-tetraacetic acid) in amphibian egg activation, 1, 315-326 Brefeldin A in calcium flux regulation studies, 2, 915- Bladder carcinoma cells action of, on G protein-coupled receptors, 925 acidic fibroblast growth factor effects on, 3, 1317-1328 in calcium inhibition, cell cycle effects of, 1, 975-988 in endoplasmic reticulum-Golgi transport 4, 293-302 of rat, fibroblast growth factor alternate disruption, coat protein accumulation cyclic AMP production and, 2, 13-25 splicing in, epithelial-mesenchymal in, 4, 413-424 okadaic acid-induced mitosis and, 2, 391- transition in, 5, 851-862 influenza virus-infected cells treated 402 transforming growth factor effects on, 1, with, hemagglutinin trimers and BAPTA (1,2 bis(2-aminophenoxy)ethane 1003-1014 monomers intracellular distribution N',N',N',N'-tetraacetic acid) Blistering diseases and, 2, 549-563 acetoxymethyl ester, in actin hemidesmosomes dysfunction in, 2, 427- in prion protein synthesis inhibition, 3, reorganization, 2, 1067-1079 438 851-863 Barium chloride Blood vessels, endothelium of proteolysis rate and, 1, 907-919 tumor necrosis factor release and, 3, 451- connexin40 in, 4, 7-20 in trans-Golgi network protein 460 tumor cell adhesion to, 2, 347-355 redistribution, 4, 93-105 Basement membrane Bombesin Bromide laminin in, 1, 731-740 DNA synthesis induction by, muscarinic in exocytosis from mast cells, 1, 337-346 merosin in, 1, 731-740 acetylcholine receptor activation 8-Bromo cGMP in polarized distribution of integrins, 2, effects on, 2, 373-381 in ion channel function, 5, 485-496 939-949 effects on cellular calcium responses, 2, 5-Bromo-2-deoxyuridine Basic fibroblast growth factor. See under 75-86 in serum response element studies, 2, Fibroblast growth factor mitogenic signaling pathways of, 1, 747- 575-588 Basic science 761 Bruch's membrane in human disease research, essay on, 3, Bone in stimulation of polarized distribution of 837-838 osteopontin in, 3, 1169-1180 integrins, 2, 939-949 National Institutes of Health and, 5, 267- Bone marrow Bryostatin 272 culture of, macrophage inflammatory in CD4 expression modulation, 2, 95-103 leukemia cells proteins produced by, colony- Basophilic stimulating factor and, 2, 403-412 BUD genes proliferation of, immunophilin ligands in cytoskeleton organization, 3, 475-479 981-987 macrophage precursor cells of, effects on, 3, prostaglandin E effects on, 1, 403- Budding B16-BL6 melanoma cells 413 in Saccharomyces cerevisiae, 3, 1025-1035 laminin of, integrin binding to, 2, 805- stromal cells of, SV40-transformed, of yeast, polarization in, extracellular 817 collagen gene transcription cues in, 5, 1169-1175 BCE1 (transcriptional enhancer) regulation in, 1, 487-498 Burkitt's lymphoma cell line in ,B-casein gene expression, 3, 699-709 syndecan expression in, 1, 27-36 phosphorylation in, ultraviolet radiation BD3 Hi cells Bone morphogenetic proteins induction of, 4, 523-530 differentiation of, ElA protein in embryonal carcinoma cell Bursa of Fabricius suppression of, 3, 1107-1115 differentiation, 3, 189-196 apoptotic lymphoblasts of, cell cycle Benzyladenine Bovine aortic endothelial cells control loss in, 5, 763-772 1-aminocyclopropane-1-carboxylate growth of, thrombospondin effects on, 3, Buspirone synthase gene expression and, 4, 181-188 in DNA synthesis, serotoninlA receptor 363-373 transfected with basic fibroblast growth activation and, 3, 961-969 BeWo cells factor Butyrate transforming growth factor receptors on, oncogenic effects on, 2, 709-718 leukocyte integrin activity on 3, 1295-1307 protein kinase C action on, 2, 719-726 nonhematopoietic cells and, 1, 359- Bicarbonate/chloride exchange Bovine ,B-casein promoter, 3, 699-709 367 in gastric parietal cells, regulation of, 2, Bovine proteins BW755C 727-737 heparin-binding growth-associated in HeLa spreading on substrates, 3, 481- Bindin molecule, 3, 85-93 492 peptides derived from, in species-specific Bradykinin BW1J cell line fertilization inhibition, 4, 375-387 cyclic AMP production stimulation by, in in liver gene regulation study, fetal vs. Binding protein(s) neurons, 2, 13-25 adult, 4, 59-69 in endoplasmic reticulum, 3, 1067-1072 fibroblast treatment with, diacylglycerol byr3 gene for growth factors, 3, 1057-1065 production in, 2, 229-239 in yeast sexual differentiation, 3, 721-734 mitosis effects on, 1, 419 mitogenic signaling pathways of, 1, 747- byrl protein kinase, of Schizosaccharomyces relocalization of, in inhibition of 761 pombe

1366 Molecular Biology of the Cell Subject Index

homology with Saccharomyces cerevisiae in chromaffin cells, catecholamine release in phosphatidate mitogenic activity, 2, protein kinases, 4, 107-120 and, 1, 683-691 57-64 byr2 protein kinase, of Schizosaccharomyces in crosslinking of IgE receptor with phospholipase D inhibition by, 2, 1011- pombe membrane skeleton, 2, 181-191 1019 homology with Saccharomyces cerevisiae in cyclic GMP accumulation, in in platelet granule secretion, 1, 1027- protein kinases, 4, 107-120 Dictyostelium discoideum, 5, 575-585 1041 cytosolic in protein kinase phosphorylation, in oscillation of, 1, 853-861 hippocampal neurons, 4, 159-172 protein kinase C**sub gamma action in prothoracic gland regulation, 1, 771- on, 5, 475-484 780 C6 glioma cells distribution of, in lymphocytes, radioactive, in calcium-binding protein Gi protein in, a subunit(s) of, subcellular ultraviolet radiation effects on, 4, characterization, 1, 167, ras oncogene distribution of, 2, 1097-1113 523-530 effects on, 1, 543-554 C10 mRNA in Duchenne myotubes, 4, 963-972 in rat brain endoplasmic reticulum, 1, in macrophage inflammatory protein in egg activation, 1, 315-326 781-790 formation, 2, 403-412 in epidermoid carcinoma cells, epidermal regulation of CAB proteins growth factor effects on, 2, 827-840 with full-length dystropin, 5, 1159- characterization of, 1, 167 in epithelial intercellular communication, 1167 Cadherins 1, 585-596 by intrasynaptic mitochondria, 3, 235- in cell adhesion, 1, 37-44 in exocytosis from mast cells, 1, 337-346, 248 mutant, cell-cell adhesion disruption 1, 523-530 in response to extracellular ATP, 3, with, 4, 37-47 extracellular 493-505 in nervous tissue, 2, 261-270 influx to Dictyostelium discoideum, 4, in sarcoplasmic reticulum, 3, 1067-1072 Caenorhabditis elegans 283-292 sensitivity to, Schizosaccharomyces pombe capping protein of, expression in yeast, 4, influx to T lymphocytes, 4, 173-184 stsl+ gene in, 3, 263-273 907-917 in parathyroid hormone release, 5, suppression of, in Schizosaccharomyces collagen genes of, 4, 803-817 725-737 pombe, nda gene mutation in, 4, G proteins in, characterization of, 2, 135- in fertilization, guanosine 5'- 1003-1015 154, glp-1 gene of, loss-of-function thiotriphosphate in, 2, 121-133 tumor necrosis factor release and, 3, 451- mutations in, 3, 1199-1213, sem-5 in Golgi function, 3, 633-654 460 gene of, replacement of, 4, 1175- in HeLa cell spreading on substrates, 3, in Xenopus egg fertilization, 4, 435-443 1188 481-492 Calcium binding proteins, Caenorhabditis sex determination of, tra-2 gene in, 3, in histamine-stimulated gastric acid elegans homologue of, functions of, 461-473 secretion, thapsigargin effects on, 2, 4, 941-952 small heat shock. protein gene expression 27-39 Calcium channels in, 3, 221-233 homeostatic mechanisms of, 1, 168-169 inositol 1,4,5-trisphosphate-gated, SPARC homologue of, functions of, 4, hormone-induced signals of, coordination caffeine-induced inhibition of, 5, 97- 941-952 of, 3, 113-121 103 vulval development in, negative in immunogloblin E receptor-mediated Calcium ion-induced calcium ion release regulators of, 5, 395-412 signal transduction, 2, 627-640 in macrophages, platelet-activating Caffeine inositol triphosphate effects on, 1, 675- factor-induced, 2, 513-522- in inositol 1,4,5-trisphosphate-gated 681 Calcium ionophores calcium channel inhibition, 5, 97- in interphase cells, regulation of, 2, 915- in calcium ion-stimulated chloride 103 925 conductance in epithelial cells, 1, in intracellular calcium release, 2, 513- intracellular 951-963 522 in cell cycle, of fibroblasts, 4, 293-302 fibroblast effects of, 2, 229-239 in mobilized calcium localization, 3, 613- release of, in macrophages stimulated in gene activation 619 by platelet-activating factor, 2, 513- in FOS-expressing cels, 1, 347-357 sensitivity to, Schizosaccharomyces pombe 522 interleukin-4 in, 1, 425-434 stsl+ gene in, 3, 263-273 Calcium mediator proteins Calbindin-D128 in macrophage activity, 3, 335-347 review of, 1, 165-172 characterization of, 1, 166 mitogen-induced effects on, 1, 75-86 Calcium release channel Calcimedins (annexins), 1, 166, 1, 168 in human leukemic T cells, 1, 99-112 activation of, heparin in, 4, 347-352 Calcineurin in mitosis Calcium-ATPase homologue (PMR1) characterization of, 1, 167 okadaic acid effects on, 2, 391-402 localization of, in Golgi system, 3, 633- in granulocyte-macrophage colony- regulation of, 2, 915-925 654 stimulating factor gene activation, 5, mobilization/release of, 1, 279-290 Calcyclin (2A9) 119-128 adenosine diphosphoribosyl cyclase in, characterization of, 1, 166 in neuron cytoskeleton, action of, 4, 2, 203-209, 2, 211-218 Caldesmon 1225-1238 by carboxy-terminally truncated phosphorylation of, 4, 669-677 Calcium and calcium ion epidermal growth factor, 2, 641-649 Calelectrins (annexins), 1, 166, 1, 168 in anthrax lethal toxin action, 3, 1269- in cell spreading, 3, 989-998 Calf serum 1277 cGMP in, 3, 373-383 fetal, in mitogen-activated protein kinase in calcium release channel activation, differential localization of, 3, 621-631 activation, 3, 63-71 heparin effects on, 4, 347-352 in dorsal root ganglion neurons, 3, Caligulin (CAB-27) in cell adhesions, cadherins and, 1, 37-44 1415-1425 characterization of, 1, 167 cellular entry of, insulin-sensitive ion neurokinin receptors in, 2, 767-779 Calmodulin channel for, 5, 485-496 in T-cell activation, 2, 841-850 antisense RNA of, in Dictyostelium, in chloride conductance in colonic in neurons, cyclic AMP production and, cytokinesis inhibition by, 3, 1403- epithelial cells, 1, 951-963 2, 13-25 1413

Vol. 5, December 1994 1367 Subject Index

in calcium influx to T lymphocytes, 4, Capping protein cARs (cyclic AMP receptors) 173-184 of Caenorhabditis elegans, expression in in calcium ion influx promotion, in gene of, expression of, developmental yeast, 4, 907-917 Dictyostelium discoideum, 4, 283-292 regulation of, 2, 819-826 in yeast, genes for, null mutation in, 4, ,B-Casein inhibitors of, cyclic AMP production and, 459-468 synthesis of, promotion of, 3, 699-709 in neurons, 2, 13-25 Carbachol Casein kinase 1 in prothoracic gland regulation, 1, 771- in cell cycle inhibition, 2, 373-381 genes for, in Saccharomyces cerevisiae, 3, 780 cyclic AMP production stimulation by, in 275-286 review of, 1, 165-167 neurons, 2, 13-25 of yeasts, dual-specificy activity of, 5, Calmodulin kinase II in gastric acid secretion, 2, 27-39 877-886 mutant, Schizosaccharomyces pombe cell in phospholipid metabolism, 2, 383-390 Catalase cycle effects of, 5, 785-795 sodium flux and, 1, 259-268 biogenesis of, in yeasts, 4, 1351-1359 Calmodulin-dependent protein 5-Carbo aminotryptamine in tubulin assembly, 3, 1141-1154 in DNA synthesis, serotoninlA receptor Catecholamines Calmodulin-regulated kinase activation and, 3, 961-969 release from chromaffin cells, calcium ion in sea urchin embryo mitosis, okadaic Carbobenzoxyphenylalanine chloromethyl levels and, 1, 683-691 acid effects on, 2, 391-402 ketone Catenins Calnexin as protease inhibitor, in T-cell receptor cadherin complexes with, 4, 37-47 as endoplasmic reticulum chaperone, 5, chain degradation studies, 2, 753- Cation-independent mannose 6-phosphate 253-265 765 receptor/insulin-like growth factor II Calpactins (annexins), 1, 166-168 Carbohydrate synthesis receptor Calpain a(1,3)fucosyltransferase activation in, 2, insulin-like growth factor II binding by, characterization of, 1, 166 989-1000 1, 197-213 Calpain inhibitors Carbon monoxide Caulobacter crescentus as protease inhibitors, in T-cell receptor in guanylyl cyclase activation, 5, 4 cell cycle of, flagellar promoter in, 3, 913- chain degradation studies, 2, 753- Carbonyl cyanide m-chlorophenyl 926 765 hydrazone C3b receptors (CR1) Calphostin C, in protein kinase inhibition mitochondrial protein effects of, 2, 165- internalization of, in neutrophils, 2, 41- cell spreading and, 4, 271-281 179 55 in tumor cell adhesion, 2, 1045-1055 proteolysis rate and, 1, 907-919 CCL39 cells Calregulin (CAB-63) Carboxypeptidase Y phospholipase activity in, thrombin characterization of, 1, 167 sorting of, in yeast, 3, 415-427 peptides effects on, 3, 95-102 Calreticulin Carcinoma cells. See also Choriocarcinoma CD 1.4 isozyme of protein kinase C as endoplasmic reticulum chaperone, 5, cells activation/translocation of, 1, 693-706 253-265 acid fibroblast growth factor effects on, 1, CD4+ cells CaM kinase 975-988 in antigen processing, 1, 500-501 of hippocampus, autophosphorylation of, adhesion to laminin, 1, 249-257 interleukin-4 gene expression regulation 4, 159-172 adhesion to vascular endothelium, 2, in, 1, 425-434 cAMP. See Cyclic adenosine 347-355 CD4 expression monophosphate cell cycle inhibition of, acetylcholine modulation of, bryostatin in, 2, 95-103 cAMP-dependent protein kinase receptor activation in, 2, 373-381 CD8+ cells catalytic subunit of embryonal, differentiation of, bone in antigen processing, 1, 501 in neurofilament phosphorylation, 5, morphogenetic protein effects on, 3, 161-172 189-196 CD62 (P-selectin, GMP-140, PADGEM) free catalytic subunit of, nuclear epidermal growth factor stimulation of, 2, cytoplasmic domain of, in sorting into translocation of, 4, 993-1002 827-840 regulated pathway of secretion, 3, in neurofilament L protein multidrug resistance chromosomes 309-321 phosphorylation, 1, 237-248 generated from, 3, 507-520 CDC genes Cancer proliferation of, inhibition by mutation in yeast signal transduction, 1, mammary, Wnt-1 proto-oncogene of, transforming growth factor-a 391-401 characterization of, 3, 532-533 oligonucleotides, 3, 1235-1243 Cdc2 protein metastasis of. See Metastasis squamous cell, transforming growth activation of, 3, 571-582 Cancer cells factor-a in, 2, 613-625 in cdc25 phosphorylation, 4, 1337-1350 integrin deficiency in, 5, 389-393 transforming growth factor effects on, 1, inhibition by INH protein phosphatase prostate, amphiregulin expression 791-809, 1, 1003-1014 in maturation-promoting factor stimulation in, epidermal growth vascular permeability factor expression activation, 5, 135-145 factor receptor in, 5, 339-347 in, 3, 211-220 mutant, in Xenopus oocyte maturation, 5, Candida boidinii Carcinosarcoma cells 587-596 peptide from, cyclophilin cross-linking to, adhesion to endothelium, arachidonic phosphorylation of, 5, 273-282 4, 223-232 acid metabolites and, 2, 1045-1055 regulation of, in cell cycle, 5, 989-1001 cap genes Cardiac myocytes in spontaneously immortalized of adenylyl cyclase-associated protein, growth factor for, 2, 1081-1095 keratinocytes, 4, 185-194 characterization of, 3, 167-180 protein kinase C translocation in, 1, 693- in Xenopus cyclin B2 degradation, 5, 713- nematode, expression in yeast, 4, 907- 706 724 917 vascular permeability factor expression CDC25 gene capl genes in, 3, 211-220 expression of, in Saccharomyces cerevisiae yeast, null mutation of, 4, 459-468 Cardiovascular system growth arrest, 4, 757-765 CAP protein, cap gene of, characterization connexins in, 4, 7-20 Cdc25 phosphatase of, 3, 167-180 CArG element of Xenopus, phosphorylation oscillations in Schizosaccharomyces pombe, 2, 155-164 in actin gene promotion, 3, 1073-1083 in, 3, 927-939

1368 Molecular Biology of the Cell Subject Index

Cdc25 protein spreading of, arachidonic acid phases of, calcium regulation in, 2, 915- in maturation-promoting factor metabolites in, 4, 271-281 925 activation, 5, 135-145 transformation of, platelet-derived protein kinase phosphorylation and in p34CdC2 regulation, 3, 73-84 growth factor and, 1, 560-561 localization during, 4, 247-260 phosphorylation site elimination in, 4, Cell adhesion. See Adhesion, cell protein phosphatase 2A, regulation in, 4, 1337-1350 Cell adhesion molecules. See also Integrin(s) 669-677 Cdc25C protein adhesion efficiency of, 3, 157-166 proteins of, in spontaneously in chromosome condensation, 3, 1373- in Dictyostelium discoideum slug size immortalized keratinocytes, 4, 185- 1388 regulation, 1, 715-729 194, ras oncogene effects on, 543- Cdc28 kinase disappearance of, in Rous sarcoma virus- 554 v-src gene expression effects on, 5, 283- modified chick lens cells, 2, 105-120 regulation of 296 in hemidesmosomes, integrin function in, calcium in, in fibroblasts, 4, 293-302 Cdc42 protein 2, 427-438 cdc25 phosphatase in, 4, 1337-1350 in cytoskeleton organization, 3, 475-479 receptor for of Saccharomyces cerevisiae prenylation of, yeast growth and, 4, in laminin isoform recognition, 5, 203- Golgi complex characterization 1017-1025 215 through, 3, 789-803 in Saccharomyces cerevisiae polarity signal transduction in, 3, 989-998 protein kinase activity, 4, 195-208 regulation, 4, 1307-1316 on tumor cell surfaces, in hematogenous ras/adenylate cyclase system in, 4, Cdk2 protein kinases metastasis, 2, 347-355 757-765 expression of, in PC12 cells, nerve Cell cycle signal transduction mediation in, 4, growth factor regulation of, 5, 1225- arrest of 107-120 1241 FAR1 protein phosphorylation in, 3, of Saccharomyces cerevisiae Cdk-activating kinase 445-450 pseudohyphae, 5, 1003-1022 in p4OMOI5 activation, in Xenopus in yeast, 391-401 of Schizosaccharomyces pombe oogenesis and embryogenesis, 5, in yeast ,B-tubulin gene mutation, 5, cedl4 gene product in, 4, 531-539 921-932 29-43, Caulobacter crescentus, DNA polymerase expression in, 4, 145- cDNA flagellar promoter in, 3, 913-926 157 casein kinase-1, isolation of, 3, 275-286 cdc2 phosphorylation in, 5, 273-282 minichromosome loss during, 5, 1145- dimerization of, multidrug resistance CDC2 protein kinase activation in, 3, 1158 chromosomes generated from, 3, 389-401 mutant calmodulin kinase II effects on, 507-520 checkpoint identification and 5, 785-795 of extracelllar signal-regulated kinases, 2, characterization in, in nda gene function in, 4, 1003-1015 965-978 Schizosaccharomyces pombe, 5, 147- in sea urchin embryos, okadaic acid in nematodes, 2, 135-154 160 effects on, 2, 391-402 chicken gro gene expression in, 2, 739- v-src gene expression effects on, 5, 283- cDNA library 752 296, Xenopus cyclin B2 degradation for immature T cells, 3, 761-773 cyclin D gene expression in, 4, 1133-1144 during, cdc2 protein kinase in, 5, cedl4 gene in Drosophila melanogaster embryo 713-724 of Schizosaccharomyces pombe, in septum growth, anaphase initiation delays of Xenopus egg extract, protein kinase formation, 4, 531-539 in, 4, 885-896 activation regulation in, 4, 397-411 CED46 gene dysregulation of, in apoptotic of Xenopus eggs, phosphorylation vs. nda gene, 4, 1003-1015 lymphoblasts from bursa of oscillations in, 3, 927-939 Cek5 (chicken embryo kinase 5) Fabricius, 5, 763-772, Escherichia coli of Xenopus embryo, protein phosphatase identification of, 2, 523-534 ribonucleotide reductase expression 1 regulation of, 3, 687-698 Cell(s) in, 3, 1095-1105, espl gene in, 3, Cell retention signals growth of 1443-1454 in platelet-derived growth factor anchorage-independent, endothelin-1 of fibroblasts, expressing E2D1 isoforms, 2, 503-512 in, 1, 379-390 transcription factor, 5, 667-678 Cell-cell interactions interferon effects on, 1, 215-226 fidelity of, monitoring of, in Drosophila, 4, cadherins in, 2, 261-270 invasion of, plasminogen activator in, 1, 885-896 Cell-free translation system 1043-1056 Gl period, gene modulation during, for protein synthesis study, 1, 1057-1067 membrane of, secretory pathway traffic nuclear proteins for, 2, 575-588 Cell-surface expression through, during mitosis, 1, 415-424 of hepatocytes, integrin binding and cell of mutant factor- migration/movement of spreading effects in, 5, 967-975 epidermal growth acidic fibroblast growth factor in, 1, inhibition of, acetylcholine receptor receptors, 1, 173-188 975-988 activation in, 2, 373-381 Cell-surface extension actin-based motors in, 1, 7-9 inositol polyphosphate formation in, mechanisms for, 1, 3 in epidermal raft cultures, transforming factors affecting, 5, 17-27 Cellular nucleic acid binding protein growth factor-a in, 2, 613-625 kinase complexes of, proliferating cell similarity to byr3 gene product, 3, 721- mechanisms for, 1, 3 nuclear antigen association with, 4, 734 myosin in, 1, 2-3 897-906, mcml-l1OL gene, arrest of, C(2)EN chromosome myosin-independent, 1, 3-4, 1, 55-63 3, 971-980 of Drosophila, anaphase initiation delay transforming growth factor in, 1, 1003- microtubule dynamics in, 4, 1035-1050 and, 4, 885-896 1014 mid-GI serum response gene cloning and, f,-Centractin urokinase plasminogen activator and, 5, 375-388 characterization of, 5, 1301-1310 1, 843-852 myogenic determination protein MyoD Centrin morphogenesis of, of Schizosaccharomyces effects on, 4, 705-713 characterization of, 1, 168 pombe, ppel+ gene in, 4, 303-313 nerve growth factor effects on, in PC12 Centromeres shape of, syndecan suppression and, 2, cells, 4, 353-361 function of, on minichromosomes from 1-11 in p34cdc2 kinases regulation, 5, 989-1001 budding yeast, 4, 859-870

Vol. 5, December 1994 1369 Subject Index

of Schizosaccharomyces pombe, 3, 819-835 of, integrin polarization on, 2, 939- Chironomus tentans function of, DNA requirements for, 5, 949 46-KDa protein of, vs. Drosophila B52 747-761 fibroblasts of protein, 5, 71-79 Centrosomes integrin cellular partitioning in, 2, 271- Chloramphenicol microtubule flux independence of, 5, 283 sensitivity to, Schizosaccharomyces pombe 217-226 myelin basic protein kinases in, stsl+ gene in, 3, 263-273 proteins of, from Drosophila embryo, activation of, 3, 1329-1337 Chloramphenicol acetyltransferase purification of, 3, 1-11 tenascin variants in, characterization in FOS-expressing cells, 1, 347-357 spindle proteins in, 2, 861-874 of, 2, 927-938 okadaic acid effects 269-278 Cerebellum on, 1, v-Src-induced mitogenesis and Chloramphenicol acetyltransferase reporter calcium channels from, inositol 1,4,5- morphologic transformation in, 5, plasmid trisphosphate-gated, caffeine- 1177-1184, gro gene of, expression in alkaline phosphatase release from induced inhibition of, 5, 97-103 of, in inflammation, 2, 739-752 cyclic AMP-resistant osteoblasts, 2, neurons of, calcineurin in, 4, 1225-1238 hepatoma cells of, mitogen-activated 889-896 c-fms gene protein kinases of, immunologic receptor for, cDNA of, 3, 761-773 characterization of, 3, 775-787 Chloride transregulation of, by granulocyte- lamin B receptor of, vs. calcium-stimulated conductance of, in macrophage colony-stimulating Schizosaccharomyces pombe stsl+ epithelial cells, 1, 951-963 factor, 3, 535-544 gene product, 3, 263-273 in exocytosis from mast cells, 1, 337-346 c-Fms protein lens epithelial cells of, transformed by Chloride/bicarbonate exchange activating mutations of, 5, 81-95 Rous sarcoma virus, intercellular in gastric parietal cells, regulation of, 2, c-fos gene adherens-type junction modulation 727-737 adenovirus early gene ElA product in, 2, 105-120 Chloroquine effects on, 2, 479-489 proteins of, heparin-binding growth- proteolysis rate and, 1, 907-919 AP-1 complex effects on, 1, 269-278 associated molecule, 3, 85-93 Chlorpromazine diisopropyl fluorophosphonate- tissue from, extracellular signal-regulated in calcium influx to T lymphocytes, 4, conjugated thrombin effects on, 1, kinases in, 2, 357-371 173-184 453-463 Chicken embryo kinase 5 CHO-Kl cells expression of identification of, 2, 523-534 P-selectin transfection of, sorting into fibronectin and tenascin regulation of, Chicken epidermal growth factor regulated secretion pathway and, 3, 5, 439-453 ligand-binding specificity of, 2, 337-345 309-321 genistein effects on, 4, 983-992 Chicken liver glycoprotein receptor 3-[(3-Cholamidopropyl)- nerve growth factor effects on, 3, 363- in endocytosis, 1, 471-486 dimethylammonio]-1-propane 371 Chicken tendon fibroblasts sulfonate (CHAPS) buffer in protein kinase C overexpression, 2, collagen gene transcription regulation in, integrins soluble in, 2, 271-283 491-502 1, 487-498 Cholera toxin transcriptional attenuation in, 4, 661- Chief cells in embryonic heart development, 1, 301- 668 sodium flux in, 1, 259-268 313 heparin effects on, 1, 435-443 Chimera, chicken/human in melanocyte terminal differentiation induction of, neurokinin receptors in, 2, epidermal growth factor receptor, ligand- and senescence, 5, 497-509 767-779 binding specificity of, 2, 337-345 in prothoracic gland function, 1, 771-780 interferon effects on, 1, 215-226 Chinese hamster lung fibroblasts Cholesterol esterase (lysosomal acid lipase) serum response element/factor action on, DNA synthesis in, a-adrenergic agonists in cholesteryl ester metabolism, 1, 661- 2, 575-588 effects on, 1, 445-451 674 transcriptional regulation of, 1, 347-357 Chinese hamster ovary cells c-Fos protein extracellular signal-regulated kinases in, Cholesteryl ester in neurite outgrowth, 3, 323-333 2, 357-371 metabolism of, lysosomal acid lipase in, CGS 9343B (calmodulin inhibitor) focal adhesion complex formation on, 1, 661-674 cyclic AMP production and, in neurons, integrin a2 in, 5, 977-988 Choline 2, 13-25 a(1,3)fucosyltransferase in, 5-azacytidine production of, in phosphatidylcholine CHAPS (3-[(3-cholamidopropyl)- activation of, 2, 989-1000 hydrolysis, 2, 299-303 dimethylammonio]-1-propane Golgi transport in, ADP-ribosylation Cholinergic response sulfonate) buffer factors in, 5, 237-252 of parietal cells, thapsigargin effects on, integrins soluble in, 2, 271-283 integrins of, 1, 883-893 2, 27-39 Checkpoint genes lymphocyte function-associated antigen 3 Chondroitin sulfate in cell cycle, mutations of, in expressed in, adhesion efficiency of, effects on gene expression in vascular Schizosaccharomyces pombe, 5, 147- 3, 157-166 smooth muscle cels, 1, 435-443 160 metaphase spindles of, microtubule- in myoblast-thrombospondin-1 adhesive Chelating agents associated proteins in, 2, 861-874 interactions, 5, 423-437 in actin reorganization modulation, 2, mitosis of, secretory pathway traffic Choriocarcinoma cells 1067-1079 during, 1, 415-424 granulocyte-macrophage colony- Chemoattractants neurokinin receptors in, 2, 767-779 stimulating factor receptor in, 1, CR1 internalization effects of, 2, 41-55 platelet-derived growth factor isoforms 327-335 Chemotaxis in, secretory pattems of, 2, 503-512 plasminogen activator degradation in, 1, of amoebas, myoA gene in, 4, 233-246 receptor trafficking in, endosome 1043-1056 of bacteria, phosphorylation cascade in, acidification and, 4, 1251-1266 stimulation by platelet-derived computer simulation of, 4, 469-482 in syndecan-1 cytoplasmic tail deletion endothelial cell growth factor, 1, myosin in, 1, 4-7 studies, 5, 1325-1339 577-584 Chicken transfected with T-cell receptor chains, transforming growth factor receptors on, embryos of, retinal pigment epithelium cysteine proteases in, 2, 753-765 3, 1295-1307

1370 Molecular Biology of the Cell Subject Index

Chromaffin cells c-kit proto-oncogene Collagen catecholamine release from, calcium ligand of, expression of, 3, 349-362 of Caenorhabditis elegans, genes of, 4, levels in, 1, 683-691 in melanocyte proliferation, 3, 197-209 803-817 Chromatin Clamp protein degradation of, transforming growth alteration of, in Schizosaccharomyces in DNA polymerase III holoenzyme factor-a in, 2, 613-625 pombe, nda gene mutation in, 4, activity, 3, 953-957 endothelial cell adhesion to, basic 1003-1015 Clathrins fibroblast growth factor effects on, 4, structure of, in Schizosaccharomyces expression of, in Schizosaccharomyces 973-982 pombe, 3, 819-835 pombe, mammalian protein kinase C HeLa cell spreading on, arachidonic acid Chromatography, Drosophila centrosomal isotypes and, 5, 907-920 metabolites in, 3, 481-492 protein purification by, 3, 1-11 light chain expression alteration in, 4, mRNA for, expression of, transforming Chromobindins (annexins), 1, 166, 1, 168 647-660 growth factor-# effects on, 2, 535- Chromosomes CLB genes 548 aberrations of, in spontaneously of Saccharomyces cerevisiae, receptors of, for integrins, 2, 905-913 immortalized keratinocytes, 4, 185- characterization of, 3, 805-818 al(I)Collagen gene 194 CLN2 protein transcriptional regulation of, 1, 487-498 disjunction of, in Drosophila melanogaster inhibition of, in yeast mating, 3, 445-450 Collagen I embryogenesis, 4, 1161-1174 Clonidine colon carcinoma cell adhesion to, 1, 249- division errors in, monitoring of, in in DNA synthesis, 1, 445-451 257 Drosophila, 4, 885-896 Cloning neurite response to, in retinoic acid- DNA fragments of, autonomous of serine/threonine protein kinase, 2, treated neuroblastoma cells, 2, 1021- replication of, 4, 1121-1132 1001-1009 1033 double minute, carrying multidrug Clostridium botulinum toxin Collagen IV resistance genes, 3, 507-520 in actin filament disruption, in insulin in fibronectin/integrin interactions lampbrush, transcription in, small nuclear secretion studies, 5, 1199-1213 studies, 2, 951-964 RNA effects on, 3, 249-261 C57MG cells polarized distribution of integrins loss of, from mcml-11OL gene, 3, 971-980 transformation of, Wnt-1 proto-oncogene stimulated by, 2, 939-949 microtubule flux independence of, 5, in, 3, 532-533 secretion of, after angiotension II-induced 217-226 c-myc gene tubular epithelial cell hypertrophy, 2, of Saccharomyces cerevisiae, replication adenovirus early gene ElA product 219-227 map of, 3, 999-1013 effects on, 2, 479-489 Collagen VI C3H/lOT1/2 fibroblast cells expression of retention on cell surface, NG2 mitogenic activity in, phosphatidates and, genistein effects on, 4, 983-992 proteoglycan and, 4, 1097-1108 2, 57-64 transcriptional attenuation in, 4, 661- Collagenase production Chymostatin 668 fibronectin and tenascin regulation of, 5, as protease inhibitor, in T-cell receptor heparin effects on, 1, 435-443 439-453 chain degradation studies, 2, 753- interferon effects on, 1, 215-226 regulation of, 1, 269-278 765 c-Myc protein transforming growth factor-a CID 9 cells mutations of, functional analysis of, 5, enhancement of, 2, 613-625 ,B-casein gene expression in, regulation of, 597-609 Colon carcinoma cells 3, 699-709 Coat proteins adhesion to laminin, 1, 249-257 Ciliary neuronotrophic factor accumulation of, in pancreatic acinar adhesion to vascular endothelium, 2, neurotrophic activity of, 1, 189-195 cells, 4, 413-424 347-355 Ciliation binding to membranes, heterotrimeric G proliferation of, inhibition by in sea urchin embryos, dynein in, 5, 57- proteins and, 3, 1317-1328 transforming growth factor-a 70 Coated pits oligonucleotides, 3, 1235-1243 Cimetidine CR1 internalization and, 2, 41-55 Colonic epithelial cells effects on chloride/bicarbonate exhange in endocytosis mediated by glycoprotein calcium-ion-stimulated chloride in parietal cells, 2, 727-737 receptor, 1, 471-486 conductance in, 1, 951-963 Cistemal stacks recruitment into, requirements for, 4, Colony stimulating factor-1 in endoplasmic reticulum, 3, 1067-1072 715-727 extracellular regulation of, 3, 1057-1065 c-jun gene Coated vesicles Colony-stimulating factor-1 adenovirus early gene ElA product in Golgi transport, independent of ADP- in prostaglandin D-regulated macrophage effects on, 2, 479-489 ribosylation factors, 5, 237-252 mannose receptor expression, 1, 403- AP-1 complex effects on, 1, 269-278 Cobalt ion 413 DNA binding inhibition in, mitogen- in actin reorganization, 2, 1067-1079 COMMA-1D cells activated protein kinases in, 3, 1117- Coelomocytes ,B-casein gene expression in, regulation of, 1130 SpCoell gene expression in, 3, 403-414 3, 699-709 expression of Coiled bodies Communication, intracellular genistein effects on, 4, 983-992 small nuclear ribonucleoprotein particles calcium ion in, 1, 585-596 nerve growth factor effects on, 3, 363- in, cell transformation and, 3, 555- Complement component factor B 371 569 in macrophage cytocidal activation, 3, induction of, neurokinin receptors in, 2, in Xenopus egg extract, 5, 633-644 335-347 767-779 Coilin Complement receptors transcriptional regulation of, 1, 347-357 insertion into amphibian germinal vesicle, internalization of, in neutrophils, 2, 41- CK11 gene 5, 1119-1127 55 in casein kinase-1 expression, 3, 275-286 Colchicine-selected KB carcinoma cells Complementation CK12 gene multidrug resistance chromosomes of protein kinases, for yeast sexual in casein kinase-1 expression, 3, 275-286 generated from, 3, 507-520 differentiation, 4, 107-120

Vol. 5, December 1994 1371 Subject Index

Computer simulation CR1 Cyclin(s) of microtubule dynamics, 4, 1035-1050 internalization in neutrophils, 2, 41-55 in cdc2 kinase inhibition, 5, 323-338 of phosphorylation cascade, in bacterial ClR lymphoid cells inhibition of, in yeast mating, 3, 445-450 chemotaxis, 4, 469-482 clathrin light chain alteration in, 4, 647- in protein kinase activation regulation, in Concanavalin A 660 Xenopus egg extract, 4, 397-411 in fibronectin/integrin interactions Creativity workshops of Saccharomyces cerevisiae, genes of, 3, studies, 2, 951-964 in graduate education, 4, 565-568 805-818 T helper cell response to, 1, 425-434 Crosslinking of Xenopus, p34"'2 binding to, 3, 13-27 Concotoxin-GVIA of IgE receptor with membrane skeleton, Cyclin A brain calcium uptake and, 1, 781-790 2, 181-191 binding to protein kinase subunits, 3, Confocal microscopy Cubane structure 1279-1294 in calcium signal coordination studies, 3, in aconitase, 4, 1-5 in cyclin-dependent kinase 2 activation, 113-121 CUG translational start codons 4, 79-92 Connective tissue growth factor in basic fibroblast growth factor in kinase activation, 3, 571-582 regulation of, in wound repair, 4, 637- oncogenicity, 2, 709-718 in p34 CDC2 kinase activation, 3, 389- 645 Cuticle 401 Connexin(s) of Caenorhabditis elegans, collagen genes in spontaneously immortalized genes for, transcription of, cAMP of, 4, 803-817 keratinocytes, 4, 185-194 regulation of, 3, 839-850 Cyclase associated protein Cyclin A-cdc2 kinase identification of, mouse gap junction in cytoskeleton organization, 3, 475-479 in endocytosis inhibition, 4, 541-553 Cx5O protein, 3, 711-720 Cyclin B phosphorylation of, inhibition of, 1, 989- Cyclic adenosine diphosphate-ribose activation of, 4, 1337-1350 1002 in calcium ion mobilization, 1, 279-290 in meiosis regulation, of starfish oocytes, Connexin37 in dorsal root ganglion neurons, 3, 4, 1295-1306 in cardiovascular system, interactions 1415-1425 in Schizosaccharomyces pombe nucleus, 4, with other connexins, 4, 7-20 Cyclic adenosine diphosphoribose 1087-1096 Connexin40 production of, egg-specific NADase for, in spontaneously immortalized in vascular endothelium, 4, 7-20 2, 193-202, 2, 203-209, 2, 211-218 keratinocytes, 4, 185-194 Connexin43 Cyclic adenosine monophosphate Cyclin Bi distribution of, 4, 7-20 in connexin43 gene transcription in kinase activation, 3, 571-582 phosphorylation of, epidermal growth regulation, 3, 839-850 Cyclin B2 factor in, 3, 865-874, 4, 837-848 in DNA synthesis, mitogen-induced, 3, of Xenopus, cell cycle-regulated Connexin45.6 961-969 degradation of, 5, 713-724 chick lens, characterization of, 5, 363-373 in enzyme activation, inhibition by G Cyclin D Conserved lymphokine element 0 protein variants, 3, 735-747 mRNA expression of, growth factor in granulocyte-macrophage colony- in growth arrest at diauxic shift, in regulation of, 4, 1133-1144 stimulated factor activation, 5, 119- Saccharomyces cerevisiae, 4, 757-765 Cyclin/cyclin-dependent kinase complexes 128 in HeLa cell spreading on substrates, 3, proliferating cell nuclear antigen d-COP (coat protein) 481-492 association with, 4, 897-906 accumulation of, in pancreatic acinar mutant osteoblasts resistant to, alkaline Cyclin-dependent kinases cells, 4, 413-424 phosphatase release and, 2, 889-896 activation of, 3, 571-582 Copper ion production of cyclin A in, 4, 79-92 in actin reorganization, 2, 1067-1079 neurokinin receptors in, 2, 767-779 dephosphorylation of, 4, 669-677 sensitivity to, Schizosaccharomyces pombe in neurons, agonist effects on, 2, 13-25 in prostaglandin E-regulated macrophage Cycloheximide stsl+ gene in, 3, 263-273 in actin gene promotion, 3, 1073-1083 Corpus luteum mannose receptor expression, 1, 403- 413 in cyclin D mRNA expression regulation, vascular permeability factor expression 4, 1133-1144 in, 3, 211-220 in prothoracic gland activity, 1, 771-780 in 3, 1229- in vinculin gene expression induction, 1, Cortical granule exocytosis receptors for, Dictyostelium, 621-636 in starfish eggs, serotonin in, 1, 453-463 1234 in calcium ion influx promotion, 4, Cyclooxygenase inhibitors COS cells cyclic AMP production and, 2, 13-25 c-kit ligand expression in, 3, 349-362 283-292 leukocyte integrin expression on, 1, 359- second messenger regulation of, 3, Cyclophilin 367 603-612 cross-linking to non-proline-containing myosin filament assembly in, 4, 105 1- signaling pathway activation in, 5, peptide, 4, 223-232 703-711 Cyclosporin A 1067 in calcineurin nerve growth factor receptor diffusion in, synthesis of, G protein oncogenes and, 3, localization, 4, 1225-1238 1, 605-614 123-128 hematopoietic cell line proliferation platelet-derived growth factor isoforms Cyclic adenosine monophosphate signaling inhibition by, 3, 981-987 in, secretory patterns of, 2, 503-512 in neurons, AKAP 150 protein in, 3, Cyproterone acetate COS-7 cells 1215-1228 syndecan expression and, 2, 1-11 P-selectin transfection of, sorting into Cyclic adenosine monophosphate-resistant cyrl gene regulated secretion pathway and, 3, phenotype of osteoblasts expression of, in Saccharomyces cerevisiae 309-321 alkaline phosphatase release by, 2, 889- growth arrest, 4, 757-765 COS-M6 cells 896 of Schizosaccharomyces pombe, 2, 155-164 guanine nucleotide-binding regulatory Cyclic GMP Cysteine proteases protein distribution in, 3, 49-61 in calcium release, in sea urchin egg in endoplasmic reticulum, in T-cell COX2 gene activation, 3, 373-383 receptor chain degradation, 2, 753- of Saccharomyces cerevisiae, mRNA cyclic AMP-mediated accumulation of, in 765 alteration in, 4, 1327-1335 Dictyostelium discoideum, 5, 575-585 CYT cells

1372 Molecular Biology of the Cell Subject Index

integrin receptor focal contact localization Cytosolic free sodium flux in myoblast-thrombospondin-1 adhesive in, 4, 593-604 in gastric cells, 1, 259-268 interactions, 5, 423-437 Cytochalasin Cytotoxic mouse T cells Diabetes mellitus in calcineurin localization, 4, 1225-1238 interleukin-2 receptor phosphorylation insulin resistance in, lipid-induced, 2, 65- Cytochalasin B and, 2, 73-85 72 in CR1 internalization, 2, 41-55 Cytotoxicity Diacylglycerol Cytochalasin D of macrophages, calcium ion in, 3, 335- in cell adhesion and spreading, 4, 271- chicken embryo fibroblasts treated by, 347 281 integrins in, 2, 271-283 mitogenic activity of, 2, 57-64 in Listeria monocytogenes invasion in phosphorylation, 3, 583-592 inhibition, 5, 455-464 production of myosin II phosphorylation and, 3, 1037- in bradykinin-stimulated fibrobasts, 2, 1048 DATP. See Adenosine triphosphate 229-239 Cytochrome c reductase Deacylcortivazol endothelin-1 in, 1, 379-390 iron-sulfur protein of, import into glucocorticoid receptor binding of, 3, in phosphatidylcholine hydrolysis, 2, mitochondria, ATP requirements for, 1245-1257 299-309 5, 465-474 Deciliation sea urchin in phospholipase D activation, 2, 841- Cytochrome oxidase of embryos, dynein gene 850, 2, 897-903 subunit of, import into mitochondria, characterization in, 5, 57-70 Decorin in sea urchin eggs, guanosine 5'- ATP requirements for, 5, 465-474 thiotriphosphate in, 2, 121-133 Cytokines thrombospondin-transforming growth factor binding and, 3, 181-188 thrombin effects on, 2, 311-316 signal transduction mechanisms of, 4, Diauxic shift 135-144 DEDA (arachidonic acid metabolism inhibitor) of Saccharomyces cerevisiae, growth arrest Cytokinesis at, 4, 757-765 in Dictyostelium, inhibition by calmodulin in calcium influx to T lymphocytes, 4, 173-184 Dibutyryl cyclic adenosine monophosphate antisense RNA, 3, 1403-1413 in alkaline phosphatase release from Cytoplasm Deglutamylation of tubulin, in mouse brain neurons, 4, cyclic AMP-resistant osteoblasts, 2, of oocytes, ras oncogene effects on, 1, 889-896 543-554 615-626 Degranulation in angiotensin II-induced tubular Cytoplasmic domain epithelial hypertrophy, 2, 219-227 of P-selectin, in sorting into regulated of IgE receptors, 2, 181-191 Dense granules (platelet) in gene activation in FOS-expressing pathway of secretion, 3, 309-321 cells, 1, 347-357 Cytoplasmic dynein factors affecting secretion from, 1, 1027- 1041 leukocyte integrin activity on light chain subunit characterization in, 5, nonhematopoietic cells and, 1, 359- 645-654 Deoxycorticosterone glucocorticoid receptor binding of, 3, 367 Cytoplasmic microtubule complex 1245-1257 in prostaglandin E-regulated macrophage interphase, microtubule dynamics in, 4, mannose receptor expression, 1, 403- 1035-1050 Deoxymannojirimycin in cell adhesion efficiency testing, 3, 157- 413 Cytoplasmic tail 166 sodium metabolism and, 1, 259-268 in endocytosis, 1, 471-486 Dephosphokinase 3,4-Dichloroisocoumarin of tissue factor, in P-selectin activity, 3, in hippocampal neurons, localization of, as protease inhibitor, in T-cell receptor 309-321 4, 159-172 chain degradation studies, 2, 753- Cytoskeleton Dephosphorylation 765 of actin, reorganization of, metal ions in, of protein, in exocytosis, 1, 523-530 Dictyostelium 2, 1067-1079 of protein kinases, protein phosphatases actin-based motor genes in, 1, 55-63 of hemidesmosomes, integrin interaction in, 4, 397-411 adenylyl cyclase in, cAMP receptors in, 3, with, 4, 871-884 1229-1234 of neurons, calcineurin in, 4, 1225-1238 Dermatan sulfate effects on gene expression in vascular calmodulin antisense RNA expression in, organization of cytokinesis inhibition by, 3, 1403- END3 gene in, 5, 1023-1037 smooth muscle cells, 1, 435-443 in myoblast-thrombospondin-1 adhesive 1413 integrins in, 5, 389-393 cell adhesion molecule effects on, 1, 715- ras-related GTPases in, 3, 475-479 interactions, 5, 423-437 Desmosome internalization 729 protein kinase C translocation to, 1, 693- AMP on 706 transforming growth factor a in, 1, 1003- cyclic receptors 1014 in calcium ion influx promotion, 4, of Saccharomyces cerevisiae, formation of, 283-292 Tcpl protein role in, 5, 1065-1080 1-Desoxymannojirmicin as mannosidase inhibitor, in influenza second messenger regulation of, 3, of yeast, actin gene null mutations in, 4, 603-612 459-468 virus hemagglutinin modification Cytosol study, 2, 549-553 G protein gene mutation in, 5, 691-702 calcium concentration of, regulation by Detergent insolubility enzyme activation and, 3, 735-747 intrasynaptic mitochondria, 3, 235- of IgE receptor, 2, 181-191 motility of, myoA gene in, 4, 233-246 248 Dexamethasone in myosin function studies, 1, 1-7 in endosome fusion, guanosine 5'-(3-O- in cytokine receptor regulation, 3, 103- myosin II of, lacking 58kD tail portion, 3, thio)triphosphate and, 1, 113-124 112 1455-1462 in recruitment into coated pits, 4, 715- glucocorticoid receptor binding of, 3, signaling pathway activation in, cAMP 727 1245-1257 receptors in, 5, 703-711 Cytosolic aconitase in virus envelope protein maturation, 1, Dictyostelium discoideum as regulatory RNA binding protein, 4, 1- 531-541 cAMP-mediated cGMP response in, 5, 5 Dextran 575-585

Vol. 5, December 1994 1373 Subject Index

Ga protein subunit Ga2 of, in DNA of platelet-derived growth factor developmental regulation, 5, 7-16 centromere, in budding yeast, 4, 859-870 receptors, 2, 651-661 2',5'-Dideoxy adenosine chromosomal, autonomous replication of, DP proteins in DNA synthesis, 3, 961-969 4, 1121-1132 of Xenopus, characterization of, 5, 1081- Differentiation of c-jun, inhibition of binding of, 3, 1092 of B cells, 1, 27-35 1117-1130 dpy genes of epidermal cells, growth factor effects damage of, cell cycle checkpoint and of Caenorhabditis elegans, 4, 803-817 on, 1, 791-809 feedback control elements for, 5, drk gene Diffusion 147-160 of Drosophila, replacing Caenorhabditis of cAMP-dependent protein kinase free mitochondrial, sorting patterns of, in elegans sem-5 gene, 4, 1175-1188 catalytic subunit, to/from nucleus, 4, yeast, 4, 21-36 Drosophila 993-1002 modification of B52 protein of, distribution within Digitonin TREF proteins in, 1, 151-164 chromosomal locus, 5, 71-79 in yeast peroxisome localization, 4, 1351- nuclear factor kappa B binding to, cells from 1359 inhibition of, 3, 1339-1352 G protein subunits from, neuronal 1,2-Diglycerides requirements of, for Schizosaccharomyces expression of, 1, 125-134 formation of, in phospholipid pombe centromere function, 5, 747- heat-shock proteins in, regulation of, 1, metabolism, carbachol effects on, 2, 761 135-149 383-390 synthesis of centrosomal proteins from, purification Dihydropyridine receptor activator of, induction in lymphocytes, of, 3, 1-11 distribution of, in transverse tubule/ 1, 1015-1025 dorsoventral polarity establishment in, 4, sarcoplasmic reticulum junctions, 5, a-adrenergic agonists stimulation of, 1, 767-771, drk gene of, replacing 1105-1118 445-451 Caenorhabditis elegans sem-5 gene, 4, Diisopropyl fluorophosphate-conjugated endothelin-1 in, 1, 379-390 1175-1188 thrombin in liver regeneration, 2, 535-548 dynein gene characterization in, 5, 45-55 as vascular smooth muscle cell mitogen, mcml-1 gene in, 3, 971-980 embryo of, anaphase initiation delays in, 1, 453-463 neurokinin receptors in, 2, 767-779 4, 885-896 4,4'-Diisothiocyanatodihydrostilbene-2,2'- phosphatidates effects on, 2, 57-64 gene expression in, transcriptional disulfonic acid retinoic acid effects on, 1, 87-97 attenuation in, 4, 661-668 effects on chloride/bicarbonate exchange ribunucleotide reductase expression histone variant H2AvD in, 3, 593-602 in parietal cells, 2, 727-737 and, 3, 1095-1105 salivary glands of, Sciara puff gene Dilauroyl phosphatidate in Saccharomyces cerevisiae, 3, 999- promoter effects on, 2, 875-888, mitogenic activity of, 2, 57-64 1013 three rows gene of, 4, 1161-1174 Dimethyl BAPTA serotoninlA receptor activation in, 3, DRTF1/E2F transcription factor in calcium inhibition, cell cycle effects of, 961-969 retinoblastoma-related protein binding to, 4, 293-302 DNA polymerase(s) 4, 389-396 Dimethyl sulfoxide of Schizosaccharomyces pombe, cell cycle Drug resistance in amphibian egg activation, 1, 315-326 expression of, 4, 145-157 genes for, double minute chromosomes leukocyte integrin activity on DNA polymerase III holoenzyme carrying, 3, 507-520 nonhematopoietic cells and, 1, 359- sliding clamp of, 3, 953-957 Drug sensitivity, Schizosaccharomyces pombe 367 DNA puff genes stsl+ gene in, 3, 263-273 Dinitrophenyl-bovine serum albumin promoters of, in Sciara coprophila, 2, 875- dskl+ gene in crosslinking of IgE receptor with 888 protein encoded by, phosphorylation of, membrane skeleton, 2, 181-191 DNA tumor viruses vs. cell cycle stage, 4, 247-260 Dinitrophenyl-lysine protein phosphatases alterations by, 2, in crosslinking of IgE receptor with 589-598 DU249 cells membrane skeleton, 2, 181-191 DnaJ mitogen-activated protein kinases of, Dinoflagellates of Escherichia coli, homologues of, immunologic characterization of, 3, motility of, dynein IC1 peptide in, 5, function with 70-kD heat shock 775-787 1051-1063 proteins, 4, 555-563 Duchenne muscular dystrophy 1,2-Dioctanoyl-sn-glycerol eukaryotic homologues of, 4, 1145-1159 dystrophin expression in, 4, 963-972 basic fibroblast growth factor mitogenic DnaK dystrophin studies in, 5, 1159-1167 activity and, 2, 719-726 eukaryotic homologues of, 4, 1145-1159 Dynamin Dioleoyl phosphatidate Dog purification and microtubule interaction mitogenic activity of, 2, 57-64 extracellular signal-regulated kinases in, of, 3, 1181-1194 Dipeptidylaminopeptidase B 2, 357-371 Dynein assembly of, sec genes in, 3, 129-142 Domain deletion cytoplasmic, light chain subunit Diphenylamine carboxylate in epidermal growth factor-receptor, 1, characterization in, 5, 645-654 effects on chloride/bicarbonate exchange 173-188 Dynein genes in parietal cells, 2, 727-737 Dorsal protein of Drosophilia melanogaster, Distearoyl phosphatidate regulation of, signal transduction characterization of, 5, 45-55 mitogenic activity of, 2, 57-64 pathway for, 4, 767-771 of sea urchins, phylogeny and expression Dithiothreitol Dorsal root ganglion neurons of, 5, 57-70 in endoplasmic reticulum-to-Golgi calcium releasing agents effects on, 3, Dynein IC1 peptide transport of immunoglobulin G, 5, 1415-1425 monoclonal antibodies to, in axoneme 1311-1324 Double minute chromosomes motility inhibition, 5, 1051-1063 Divalent cations carrying multidrug resistance genes, 3, Dystropin sensitivity to, Schizosaccharomyces pombe 507-520 full-length, in transgenic mice, normal stsl+ gene in, 3, 263-273 Down-regulation calcium regulation in, 5, 1159-1167

1374 Molecular Biology of the Cell Subject Index

Ela oncogene from bindin, 4, 375-387, Xenopus Endocytosis in transcriptional repression reversal, 4, cell cycle of, p34cdc2 regulation in, 5, Brefeldin A effects on, 4, 93-105 389-396 989-1001 in CR1 internalization, 2, 41-55 ElA proteins cyclin A in, 3, 1279-1294 cyclin A-cdc2 kinase inhibition of, 4, of adenovirus, in suppression of myoblast fertilization of, inositol 1,4,5- 541-553 differentiation, 3, 1107-1115 trisphosphate mass changes in, 4, epidermal growth factor recruitment for, in nerve growth factor inhibition of PC12 435-443 4, 715-727 cell differentiation, 4, 353-361 protein kinase activation in, protein glycoprotein receptors in, 1, 471-480 transforming growth factor activity and, phosphatases in, 4, 397-411 of insulin receptors, kinase-dependent, 5, 3, 655-665 Egg extract, Xenopus 539-547 Early response genes cdc2 kinase inhibition in, 5, 323-338 mannose 6-phosphate-dependent, 1, of adenovirus, in pheochromocytoma cell cdc2 phosphorylation in, 5, 273-282 197-213 differentiation inhibition, 2, 479-489 coiled body assesmbly in, 5, 633-644 of pheromone receptor, in Saccharomyces induction of, neurokinin receptors in, 2, cyclin B2 of, cell cycle-regulated cerevisiae, 4, 511-521 767-779 degradation of, 5, 713-724 in Saccharomyces cerevisiae, END3 gene in, in kidney, after ischemia and reperfusion, maturation-promoting factor in 5, 1023-1037 2, 251-260 MPM-2 antigen activation of, 5, in Schizosaccharomyces pombe regulation of 135-145 mammalian protein kinase C isotypes granulocyte-macrophage colony- microtubule flux independence studies and, 5, 907-920 stimulating factor in, 4, 983-992 in, 5, 217-226 ypt5 gene product in, 4, 583-592 transcriptional, 1, 347-357 egr-1 (immediate early growth response of selectins, fate after, 4, 791-801 serum response element/factor action on, gene) of STE6 protein, of Saccharomyces 2, 575-588 adenovirus early gene ElA product cerevisiae, 5, 1185-1198 Early response kinase effects on, 2, 479-489 transferrin receptor recruitment for, 4, activation of, 3, 123-128 in kidney, after ischemia and reperfusion, 715-727 E-cadherin 2, 251-260 Endoglycosidase H resistance in cell adhesion, 1, 37-44 transcriptional regulation of, 1, 347-357 in secretory pathway during mitosis, 1, Ecdysone EGTA (ethylene glycol bis(beta-aminoethyl 415-424 as DNA puff gene promoter, 2, 875-888 ether)-N'N'N'N'-tetraacetic acid) Endoplasmic reticulum Ecdysteroids in crosslinking of IgE receptor with of brefeldin A-treated cells, influenza prothoracic gland production of, 1, 771- membrane skeleton, 2, 181-191 virus hemagglutinin trimers and 780 cyclic AMP production and, 2, 13-25 monomers in, 2, 549-563 9E3/CEF4 (chicken gro gene) expression okadaic acid-induced mitosis and, 2, 391- compartments of, 3, 1067-1072 in inflammation, 2, 739-752 402 cysteine proteases in, 2, 753-765 E2D1 transcription factor Eicosanoids glycoprotein folding in, N-linked in fibroblasts, alterations produced by, 5, in HeLa spreading on substrates, 3, 481- oligosaccharides in, 5, 253-265 667-678 492 interactions of Kar2 protein and SEC63 Education ELAM-1 (endothelial leukocyte adhesion protein in, 4, 1145-1159 biology, 3, 959-960 molecule-1) membrane of, protein translocation graduate, creativity workshops in, 4, 565- endothelial cell activation by, tumor cell across, 2, 851-859 568 adhesion and, 2, 347-355 polypeptide insertion into, sec6lp gene in, science, 3, 1195-1197 Electrolytes 3, 129-142 undergraduate, improvement of, 5, 129- in exocytosis from mast cells, 1, 337-346 134 Electron microscopy proteolysis in, 1, 907-919 E2F proteins in visualization of G, protein in a of rat brain, calcium ion distribution in, 1, of Xenopus, DP protein interactions with, subunit(s) subcellular distribution, 2, 781-790 5, 1081-1092 1097-1113 ribosome targeting to, by signal EF-hand motif Electrophoresis recognition particle, 5, 887-897 of calcium binding proteins, 1, 166-167 in Saccharomyces cerevisiae chromosome secretory protein translocation to, 3, 895- Eg5 (microtubule motor protein) III circular derivative mapping, 3, 911 microtubule flux independence of, 5, 999-1013 stress on, stress protein formation in, 4, 217-226 Electroporation 1109-1119 Egg(s). See also Oocytes of sea urchin eggs, 1, 65-74 transport to Golgi apparatus activation of Embryo, Drosophila disruption of, coat protein calcium ion increase in, 1, 315-326 anaphase initiation delays in, 4, 885-896 accumulation in, 4, 413-424 serotonin in, 1, 453-463 centrosomal proteins from, purification of immunoglobulin G, 5, 1311-1324 calcium ion mobilization in, 1, 279-290 of, 3, 1-11 inhibition of, binding protein electroporation of, 1, 65-74 Embryogenesis relocalization in, 5, 1119-1127 molluscan, NADase of, characterization in Xenopus, p40MO15 in, 5, 921-932 during mitosis, 1, 415-424 of, 2, 193-202, 2, 203-209, 2, 211- Embryonal carcinoma cells vesicle budding in, promotion of, 3, 667- 218 urokinase-type plasminogen activator 676 sea urchin expression in, factors affecting, 2, vma2l membrane protein in, in hydrogen activation of, by cGMP, 3, 373-383 285-297 ion-ATPase complex assembly, 5, adenosine diphosphoribosyl cyclase Embryonic heart development 1039-1050 effects on, 2, 203-209 signal transduction in, 1, 301-313 yeast guanosine 5'-thiotriphosphate effects END3 gene polypeptide translocation into, 4, 931- on, 2, 121-133, Strongylocentrotus, in Saccharomyces cerevisiae endocytosis 939 fertilization of, species-specific and actin cytoskeleton organization, protein degradation in, 4, 729-736 inhibition of, by peptides derived 5, 1023-1037 protein translocation into, 4, 919-930

Vol. 5, December 1994 1375 Subject Index

Endosomes egg-specific, molluscan, characterization heparin effects on, 1, 435-443 acidification of, receptor trafficking and, of, 2, 193-202, 2, 203-209, 2, 211- stimulation by, 1, 821-831 4, 1251-1266 218 in vinculin gene expression induction, 1, fusion of Enzyme assay 621-636 guanosine 5'-(3-O-thio)triphosphate in, sea urchin egg pore formation for, 1, 65- Epidermal raft cultures 1, 113-124 74 cell migration in, transforming growth ypt5 protein in, 4, 583-592 EpH family of tyrosine kinase factor-a in, 2, 613-625 selectins in, 4, 791-801 in chicken embryo, 2, 523-534 Epidermis vesicle fusion in, N-ethylmaleimide Epidermal growth factor growth factor effects on, 1, 791-809 inhibition of, 5, 773-783 action of, on spontaneously immortalized retinoic acid effects on, 1, 791-809, 1, Endothelial cell growth factor-like protein keratinocytes, 4, 185-194 965-973 (heparin-binding growth-associated in connexin43 phosphorylation, 3, 865- Epidermoid carcinoma cells molecule) 874 proliferation of, immunophilin ligands characterization of, 3, 85-93 in cyclin D mRNA expression regulation, effects on, 3, 981-987 Endothelial cell-fibroblast coculture system 4, 1133-1144 Epinephrine cholesteryl ester metabolism in, 1, 661- in DNA synthesis, serotoninlA receptor in DNA synthesis, 1, 445-451 674 activation and, 3, 961-969 Epithelial cells and epithelium Endothelial cells and endothelium with endothelin-1, in cell proliferation, 1, actin reorganization in, heavy metal ions of atrioventricular canal, embryonic 379-390 in, 2, 1067-1079 transformation of, 1, 301-313 epidermoid carcinoma cell stimulation by, adhesion in, disruption with mutant glycosylation-deficient, response to 2, 827-840 cadherins, 4, 37-47 transforming growth factor-beta, 4, extracellular regulation of, 3, 1057-1065 calcium-ion-stimulated chloride 135-144 fibroblast effects of, 2, 229-239 conductance in, 1, 951-963 invasion by Listeria monocytogenes, fibroblast treatment with, microtubule- hemidesmosomes in, integrin function in, mitogen-activated protein kinase associated protein kinase 2, 427-438 phosphorylation in, 5, 455-464 phosphorylation of, 2, 663-673 intercellular communication of, 1, 585- laminin in, 1, 731-740 in gap junction communication 596 microvascular, integrin expression in, disruption, 4, 837-848 laminin in, 1, 731-740 basic fibroblast growth factor in gene activation in FOS-expressing mouse mammary modulation of, 4, 973-982 cells, 1, 347-357 epidermal growth factor receptor programmed death of, extracellular in glioblastoma multiforme down-regulation in, 4, 773-780 matrix blocking of, 4, 953-961 pathophysiology, 4, 121-133, gro ras-transformed, syndecan-1 P-selectin of, in sorting into regulated gene expression and, 2, 739-752 translational expression in, 4, 849- secretion pathway, 3, 309-321 intracellular calcium levels affected by, 2, 858 stimulation by platelet-derived 57-64 neoplastic transformation by deregulated endothelial cell growth factor, 1, intracellular routing of, 2, 599-612 myc expression, 1, 863-872 577-584 in keratinocyte proliferation, 2, 613-625 vascular permeability factor expression transfected with basic fibroblast growth mitogenic signaling pathways of, 1, 747- in, 3, 211-220 factor 761, myc-transformed mouse of villi, tenascin variants under, 2, 927- oncogenic effects on, 2, 709-718 mammary epithelial cells response 938 protein kinase C action on, 2, 719-726 to, 1, 863-872 viral glycoprotein transport in, tumor cell adhesion to, arachidonic acid in neuronal differentiation, 3, 545-553 microtubule perturbation and, 1, metabolites in, 2, 1045-1055 vs. pheochromocytoma cell-derived 921-936 umbilical vein, G, protein in, a subunit(s) factor, 1, 511-521 Epithelial phenotype of, subcellular distribution of, 2, in phosphoinositide hydrolysis induction, conversion to fibroblastic phenotype, 1097-1113 1, 615-620 steroid-induced, 2, 1-11 vascular protein kinase activity and, 4, 71-78 Epithelial-mesenchymal transition connexin40 in, 4, 7-20 receptor for, 1, 173-188 acidic fibroblast growth factor and, 1, injury of, tyrosine phosphorylation in, in amphiregulin expression stimulation, 975-988 5, 349-361 5, 339-347 fibroblast growth factor receptor tumor cell adhesion to, 2, 347-355 carboxy-terminal region of, activity of, alternative splicing in, 5, 851-862 vascular endothelial growth factor 2, 641-649 ER-1 (bovine fl-casein promoter), 3, 699- stimulation in, in glioblastoma desensitization of, in PC12 cells, 4, 709 multiforme, 4, 121-133 737-746 ERK2 (mitogen activated protein kinase) Endothelial leukocyte adhesion molecule-1 in insulin receptor endocytosis, 5, 539- homology to yeast protein kinases, 4, endothelial cell activation by, tumor cell 547 107-120 adhesion and, 2, 347-355 ligand-binding specificity of, 2, 337- ERKs. See Extracellular signal-regulated Endothelin(s) 345 kinases in vascular smooth muscle cell mutation of, responsiveness Erythrocytes stimulation, 1, 649-659 enhancement by, 5, 739-746 marginal bands of, microtubule dynamics Endothelin-1 neu tyrosine kinase activation effects of, 4, 323-335 DNA synthesis stimulation mechanism on, 2, 651-661 Erythroleukemia cells of, 1, 379-390 prolactin down-regulation of, 4, 773- fibronectin receptor overexpression in, 1, in phospholipase D activation, 2, 897- 780 637-648 903 transforming growth factor binding to, integrin transfection of, in laminin ENL protein 3, 1235-1243 isoform recognition, 5, 203-215 implicated in human leukemia, similarity recruitment for endocytosis, 4, 715-727 Erythropoiesis to Ancl protein of Saccharyomyces in urokinase-type plasminogen activator globin gene promoters in, 4, 1077-1085 cerevisiae, 5, 617-632 expression, 2, 285-297 Escherichia coli Enzyme(s) in vascular smooth muscle preparation chemotaxis in, phosphorylation cascade

1376 Molecular Biology of the Cell Subject Index

in, computer simulation of, 4, 469- guanosine-5'-O-(thiotriphosphate)- in cell cycle, mutations of, in 482 induced, protein dephosphorylation Schizosaccharomyces pombe, 5, 147- DNA polymerase III holoenzyme of, 3, in, 1, 523-530 160 953-957 of proteoglycan, in parathyroid hormone Ferrous ion dnaJ of, homologues of, function with release, extracellular calcium ion in, in actin reorganization, 2, 1067-1079 70-kD heat shock proteins, 4, 555- 5, 725-737 Fertilization 563 in Saccharomyces cerevisiae, protein egg activation in, 1, 453-463 enteropathic, invasion mechanisms of, 5, degradation in, 4, 729-736 guanosine 5'-thiotriphosphate in, 2, 121- 455-464 in Schizosaccharomyces pombe, ypt2 gene 133 ribonucleotide reductase expression in, 3, in, 4, 1069-1076 inhibition of, by peptides derived from 1095-1105 Experimentation bindin, 4, 375-387 E-selectin ideas in, essay on, 3, 385-388 inositol 1,4,5-trisphosphate mass changes fate of, after expression on plasma Extracellular matrix in, 4, 435-443 membrane, 4, 791-801 in f,-casein synthesis, 3, 699-709 okadaic acid effects on, 2, 391-402 espl gene as cell survival factor, 4, 953-961 Fetus in Saccharomyces cerevisiae nuclear in cell-cycle control, integrin binding and globin gene expression in, 4, 1077-1085 division, 3, 1443-1454 cell spreading effects on, 5, 967-975 liver gene regulation in, 4, 59-69 of Schizosaccharomyces pombe, mitosis collagenase gene expression regulation in, fgdC gene product and, 4, 337-345 fibronectin and tenascin in, 5, 439- in cAMP receptor regulation, 3, 603-612 Estrogen 453 Fibrinogen in amphiregulin expression, in prostate degradation of, urokinase-type binding to integrins, 1, 883-893 cancer cells, 5, 339-347 plasminogen activator in, 2, 793-803 cell spreading on, platelet integrin receptor for growth factor interactions in, 3, 1057- expression and, 3, 989-998 nuclear localization regulation ion, 1, 1065 Fibroblast(s) 291-299 of hepatocytes, in tubulin monomer actin reorganization in, heavy metal ions thyroid hormone receptor activity and, regulation, 5, 1277-1280 in, 2, 1067-1079 2, 565-574 melanoma invasion of, nerve growth bradykinin effects on, 2, 229-239 Ethanol factor in, 4, 1205-1216 cAMP-dependent protein kinase free effects on phosphatidylcholine proteins of, fibronectin binding to, 2, catalytic subunit injection into, metabolism, endothelin-1 stimulated, 927-938 nuclear translocation of, 4, 993-1002 2, 897-903 signal integration in, integrins in, 5, 389- cardiac, in myocyte growth modulation, n-Ethyl maleimide 393 2, 1081-1095 glycosaminoglycan transport and, 1, 415- vascular endothelial growth factor cell cycle of, regulation of, calcium in, 4, 424 isoforms in, 4, 1267-1275 293-302 5'-(N-Ethylcarboxamido)-adenosine Extracellular signal-regulated kinases chicken embryo in actin polymerization, 5, 313-322 activation of, 3, 63-71, 3, 299-308 integrin cellular partitioning in, 2, 271- Ethylene in epidermal growth factor receptor 283 in deepwater rice growth, 1- phosphorylation, 4, 737-746 tenascin variants in, characterization aminocyclopropane- 1-carboxylate identification of, 2, 357-371 of, 2, 927-938 synthase gene expression and, 4, phosphorylation of, repression of, v-Src-induced mitogenesis and 363-373 melanocyte growth and, 5, 497-509 morphologic transformation in, 5, Ethylene glycol bis(beta-aminoethyl ether)- review of, 2, 965-978 1177-1184 N'N'N'N'-tetraacetic acid. See EGTA cholesteryl ester metabolism in, 1, 661- [Ethylene-bis(oxyethylenenitrilo)] tetraacetic 674 acid collagen gene transcription regulation in, in cyclic adenosine diphosphate-ribose F9 embryonal carcinoma cells 1, 487-498 action, 1, 279-290 transcriptional activity in, retinoblastoma- collagen receptors on, wound healing N-Ethylmaleimide related protein effects on, 4, 389-396 and, 2, 1035-1044 in endosomal vesicle fusion inhibition, 5, F-actin collagenase gene expression in, regulation 773-783 binding of, in yeast mitochondria, 5, 807- of, 5, 439-453 as protease inhibitor, in T-cell receptor 818 cyclin D mRNA expression in, growth chain degradation studies, 2, 753- Factor B (complement) factor regulation of, 4, 1133-1144 765 in macrophage cytocidal activation, 3, diacylglycerol production in, 2, 311-316 Ethylmethane sulfonate 335-347 DNA synthesis in, a-adrenergic agonists in a(1,3)fucosyltransferase studies, 2, FA-K562 erythroleukemia cells effects on, 1, 445-451 989-1000 fibronectin receptor overexpression in, 1, endothelin-1 effects on, 1, 379-390 Ethylnitrosourea 637-648 epidermal growth factor treatment of, in a(1,3)fucosyltransferase activation, 2, FAR1 protein, phosphorylation of microtubule-associated protein 989-1000 in cell-cycle arrest, 3, 445-450 kinase phosphorylation of, 2, 663- Eukaryotes FUS3 in, 4, 107-120 673 gene expression in, transcriptional Famesyl transferase expressing E2D1 transcription factor, attenuation in, 4, 661-668 in yeast growth, 4, 1017-1025 alterations in, 5, 667-678 Eukaryotic homologues Fatty acyl-coenzyme A fibronectin/integrin interactions in, of Escherichia coli dnaJ, function with 70- in asialoglycoprotein receptor activity protein (120-kDa) phosphorylation kD heat shock proteins, 4, 555-563 regulation, in hepatocytes, 5, 227- in, 2, 951-964 Excitation-contraction coupling 235 focal adhesion in, syndecan 4 heparan in skeletal muscle, transverse tubule/ FDC-P1/MAC cells sulfate proteoglycan in, 5, 183-192 sarcoplasmic reticulum junction growth factor receptors on, G, protein in, a subunit(s) of, subcellular organization in, 5, 1105-1118 transregulation of, 3, 535-544 distribution of, 2, 1097-1113 Exocytosis Feedback control genes growth factor-stimulated, inositol

Vol. 5, December 1994 1377 Subject Index

polyphosphate formation in, 5, 17- in myocyte growth modulation, 2, Fimbrin 27 1081-1095 in yeast, gene for, null mutation in, 4, heparanase activity and, 1, 833-842 in neurite outgrowth, 3, 323-333 459-468 in human skin, connective tissue growth in neuronal differentiation, 3, 545-553 Firefly luciferase factor gene expression in, 4, 637-645 oncogenic effects of, 2, 709-718 import of, into Trypanosoma brucei interferon effects on, 1, 215-226, 1, 707- in phospholipid metabolism, 2, 383- glycosomes, 3, 749-759 713 390 Fission yeast. See Schizosaccharomyces pombe locomotion of, myosin II concentration protein kinase C activation of, 2, 719- FK506 and assembly in, 4, 819-836 726 hematopoietic cell line proliferation mitogen-activated protein kinases of, 2, signal transduction mechanisms of, 4, inhibition by, 3, 981-987 675-684, 3, 63-71 135-144 Flagellar movement mitogenic activity in, phosphatidates and, in urokinase-type plasminogen by dynein IC1 peptide in, 5, 1051-1063 2, 57-64 activator expression, 2, 285-297 Flagellar promoter muscle-specific actin gene promoter in cellular protein phosphorylation, 3, in Caulobacter crescentus cell cycle, 3, activation in, 3, 1073-1083 1049-1056 913-926 myelin basic protein kinases in, activation heparanase release of, 1, 833-842 Flavin adenine dinucleotide of, 3, 1329-1337 receptor for, alternate splicing in, in alcohol oxidase assembly, in Hansenula neural cell adhesion molecule-heparin epithelial-mesenchymal transition in, polymorpha, 5, 829-837 interaction in, 1, 567-576 5, 851-862 Fluorescein indicators neurotrophin receptor in vascular smooth muscle cell in parietal cell chloride/bicarbonate autophosphorylation inhibition in, 3, stimulation, 1, 821-831 exchange studies, 2, 727-737 677-686 in vinculin gene expression induction, 1, Fluorescence in situ hybridization nuclear factor kappa B-like activity 621-636 in small nucleolar ribonucleoproteins induced in, 3, 1131-1139 Fibroblastic changes, in mouse mammary organization characterization, 5, phorbol-ester exposed, talin tumor cells, steroid-induced, 2, 1-11 1289-1299 phosphorylation and, 1, 227-236 Fibroblastoid cells Fluorescent indicators protein kinase C overexpression in, leukocyte integrin expression on, 1, 359- in sodium flux study, 1, 259-268 endothelin-1 effects on, 2, 897-903 367 Focal adhesion protein kinase C translocation in, 1, 693- Fibronectin complexes of, formation of, integrin a2 in, 706 adhesive interactions with skeletal 5, 977-988 serum-deprived, myosin II myoblasts, 5, 423-437 syndecan 4 heparan sulfate proteoglycan phosphorylation in, 3, 1037-1048 cellular localization on, 4, 593-604 in, 5, 183-192 small nuclear ribonucleoprotein particle colon carcinoma cell adhesion to, 1, 249- Focal adhesion kinase localization in, 3, 555-569 257 activity of, in injured endothelial cells, 5, spreading of, fibronectin-derived endothelial cell adhesion to, basic 349-361 synthetic peptide in, 4, 605-613 fibroblast growth factor effects on, 4, v-Src protein interaction with, 5, 413-421 transfected with serotoninlA receptors, 3, 973-982 Folding 961-969 interaction with integrin, protein (120- of glycoproteins, in endoplasmic vinculin gene expression in, 1, 621-636 kDa) phosphorylation induced by, 2, reticulum, N-linked oligosaccharides Fibroblast growth factor 951-964 in, 5, 253-265 acidic interferon effects on, 1, 215-226 Formyl methionyl Jeucyl phenylalanine function of, vs. cell density, 1, 975-988 mouse mammary tumor cells binding to, CR1 internalization effects of, 2, 41-55 with glia maturation factor f3, steroid effects on, 2, 1-11 Forskolin antiproliferative function of, 1, 741- mRNA for, expression of, transforming cyclic AMP production and, 2, 13-25 746, 1, 741-746 growth factor-,B effects on, 2, 535- effects on angiotensin II-induced tubular gro gene expression stimulation by, 2, 548 epithelial hypertrophy, 2, 219-227 739-752 neurite response to, in retinoic acid- in gap junction communication, of in myocyte growth modulation, 2, treated neuroblastoma cells, 2, 1021- hepatoma cells, 3, 839-850 1081-1095 1033 in gastric acid secretion, 2, 27-39 in urokinase-type plasminogen polarized distribution of integrins and, 2, leukocyte integrin activity on activator expression, 2, 285-297 939-949 nonhematopoietic cells and, 1, 359- basic production of, in endothelial cells, 367 in epidermal growth factor receptor cytokine effects on, 4, 135-144 Frog desensitization, 4, 737-746 receptors for, overexpression in K562 cell extracellular signal-regulated kinases in, extracellular regulation of, 3, 1057- variants, 1, 637-648 2, 357-371 1065 synthetic peptide derived from, in cell Fucoidan gene activation by, in FOS-expressing adhesion, 4, 605-613 in myoblast-thrombospondin-1 adhesive cells, 1, 347-357 with tenascin, in collagenase gene interactions, 5, 423-437 in gro gene expression, 2, 739-752 expression regulation, 5, 439-453 a(1,3)Fucosyltransferase high molecular weight tenascin variant binding to, in chicken 5-azacytidine activation of, 2, 989-1000 methylated argininine residues on, 2, embryo fibroblasts, 2, 927-938 FUS gene expression 87-93 thrombospondin-transforming growth in yeast gene mutation, 1, 391-401 oncogenicity of, 2, 709-718 factor binding and, 3, 181-188 FUS3 genes selective expression of, 2, 699-708 Fibrosarcoma cells mutations of, promoting in integrin modulation, in vascular vascular permeability factor expression autophosphorylation, in yeast endothelial cells, 4, 973-982 in, 3, 211-220 mating, 5, 297-312 in mitogen-activated protein kinase Filamentous structures FUS3 protein kinase stimulation, 2, 675-684 phosphorylation effects on, 1, 237-248 of Saccharomyces cerevisiae, homology mitogenic signaling pathways of, 1, Filaments with Schizosaccharomyces pombe 747-761 actin, 3, 1309-1315 protein kinases, 4, 107-120

1378 Molecular Biology of the Cell Subject Index

in signal transduction mediation, in GAP (GTPase activating protein of Ras) in embryonic heart development, 1, 301- yeasts, 4, 495-510 tyrosine phosphorylation of, 2, 413-425 313 Fusion Gap junction(s) in Listeria monocytogenes invasion of endosomes, guanosine 5'-(3-O- channels in, in calcium signal inhibition, 5, 455-464 thio)triphosphate in, 1, 113-124 coordination, 3, 113-121 in recruitment into coated pits, 4, 715- communication at 727 disruption of, epidermal growth factor in signal transduction, 2, 627-640 in, 3, 865-874 Geranylgeranylation epidermal growth factor effects on, 4, of rab9 protein, 4, 425-434 Ga protein 837-848 Geranylgeranyltransferase I subunit Ga2 of, Dictyostelium discoideum, in vascular endothelium, connexin40 in, of yeasts, defect in, GTPase prenylation in developmental regulation, 5, 7-16 4, 7-20 and, 4, 1017-1025 Gi protein Gap junction protein connexin43 Germinal vesicles a subunit(s) of, subcellular distribution gene for, transcription of, cAMP amphibian, human p80-coilin insertion of, 2, 1097-1113 regulation of, 3, 839-850 into, 5, 1119-1127, 5, 1119-1127 G proteins (guanine nucleotide-binding phosphorylation of, epidermal growth of starfish oocytes, breakdown of, 4, regulatory proteins) factor in, 3, 865-874 1027-1034, 4, 1295-1306 in actin polymerization, 5, 313-322 Gap junction protein connexin5O GF-6B3 (growth factor) of Dictyostelium, amino acid substitutions identification as lens fiber protein MP70, activity of, 1, 511-521 in, enzyme activation and, 3, 735- 3, 711-720 Giantin 747 Gap junction proteins in Golgi membrane, characteristics of, 4, distribution of, gamma-subunit phosphorylation of, inhibition of, 1, 989- 679-693 prenylation in, 3, 49-61 1002 Gizzard in fertilization, 2, 121-133 Gastric acid secretion tenascin variants in, 2, 927-938 heterotrimeric, in membrane traffic, 3, calcium role in, 2, 27-39 Glia maturation factor a 1317-1328 chloride/bicarbonate exchange in, antiproliferative function of, 1, 741-746 in mitogen-activated protein kinase regulation of, 2, 727-737 Glioblastoma cells activity, 2, 675-684 Gastric cells in RAP gene studies, 1, 763-769 in nematodes, characterization of, 2, 135- cytosolic free sodium flux in, 1, 259-268 Glioblastoma multiforme 154 GDP-dissociation inhibitors pathophysiology of, epidermal growth in neutrophil NADPH oxidase activation, in cytoskeleton organization, 3, 475-479 factor in, 4, 121-133 4, 261-269 GDP-dissociation proteins Glioma cells oncogenes of, in mitogenesis regulation, complexation with Rab proteins, 4, 425- collagen binding to, NG2 proteoglycan 3, 123-128 434 and, 4, 1097-1108 pertussis toxin-sensitive, in serotoninlA Gelatin G, protein in, a subunit(s) of, subcellular receptor mitogenicity, 3, 961-969 HeLa cell spreading on, arachidonic acid distribution of, 2, 1097-1113 in phosphoinositide hydrolysis, 1, 615- metabolites in, 3, 481-492 vascular endothelial growth factor 620 Gelatinase production stimulation in, 4, 121-133 in phospholipase D activation, 2, 1011- transforming growth factor-a 1019 Globin gene expression enhancement of, 2, 613-625 1077-1085 in platelet granule secretion, 1, 1027- Gelsolin promoters for, 4, 1041 in actin polymerization, 3, 1427-1435 glp-1 gene in Saccharomyces cerevisiae polarity Gene(s) of Caenorhabditis elegans, loss-of-function regulation, 4, 1307-1316 amplification of, for multidrug resistance mutations in, 3, 1199-1213 in starfish egg activation, 1, 453-463 studies, 3, 507-520 mutation of, dpy gene suppression of, 4, in starfish oocyte maturation, 4, 1027- early response, regulation of, 803-817 1034 granulocyte-macrophage colony- Glucocorticoids subunits of stimulating factor in, 4, 983-992 receptors for in Dictyostelium, mutation of, 5, 691- induction of, platelet-derived growth characterization of, 3, 1245-1257 702 factor in, 1, 558 nuclear localization regulation in, 1, in Drosophila, neuronal expression of, regulation of 291-299 1, 125-134 collagenase, 1, 269-278 in virus envelope protein maturation, 1, in prothoracic gland, 1, 771-780 early growth response, 1, 347-357 531-541 as yeast microtubule-associated proteins, growth factor-inducible, 1, 215-226 Gluconate 3, 29-47 heparin effects on, in vascular smooth in exocytosis from mast cells, 1, 337-346 in yeast signal transduction, 1, 391-401 muscle cells, 1, 435-443 Glucose uptake ,-Galactosidase interferon-induced, 1, 707-713 in Xenopus laevis oocytes, vanadate expression of, in cell cycle, 3, 1095-1105 interleukin-4, 1, 425-434 effects on, 2, 317-327 synthesis of, in Caenorhabditis elegans, 3, vinculin, 1, 621-636 Glucose-regulated protein 221-233 transcription of mitosis effects on, 1, 419 f3-Galactosidase-receptor protein fusion in collagen, 1, 487-498 Glucose-regulated proteins derivatives, 1, 291-299 TREF proteins effect on, i, 151-164 in endoplasmic reticulum, 4, 1109-1119 a 1,2 Galactosyltransferase activity Gene therapy interactions with mitochondrial proteins, localization of, in Schizosaccharomyces in Duchenne muscular dystrophy, animal 2, 165-179 pombe Golgi apparatus, 5, 519-528 studies of, 5, 1159-1167 Glucose-regulated/Ig heavy-chain binding Gallbladder Gene transcription factors protein osteopontin in, 3, 1169-1180 activation of, 2, 329-335 gene of, regulation of, 3, 143-155 Gamma-subunit prenylation Genistein ,B-Glucuronidase in guanine nucleotide-binding regulatory in early response gene activation, 4, 983- in insulin-like growth factor II binding, 1, protein distribution, 3, 49-61 992 197-213

Vol. 5, December 1994 1379 Subject Index

Glutamate protein transport to, yeast proteins in, 3, insulin-like, in cyclin D mRNA in exocytosis from mast cells, 1, 337-346 667-676 expression regulation, 4, 1133-1144 Glutamic acid residues of Saccharomyces cerevisiae, through cell integrin synergism with, 5, 389-393 of collagen, in platelet adhesion/ cycle, 3, 789-803 keratinocyte, in epithelial-mesenchymal activation, 2, 905-913 of Schizosaccharomyces pombe, a 1,2 transition, in rat bladder carcinoma Glutamylation galactosyltransferase activity cells, 5, 851-862 of tubulin, in mouse brain neurons, 4, localization in, 5, 519-528 macrophage-derived, 1, 811-819 615-626 secretory pathway from, during mitosis, in mitogen-activated protein kinase Glyceraldehyde 3-phosphate 1, 415-424 activation, 3, 63-71 dehydrogenase selectins in, 4, 791-801 mitogenic signaling pathways of, 1, 747- as yeast microtubule-associated protein, gpl30 761, myc-transformed mouse 3, 29-47 phosphorylation of, in Jak2 kinase mammary epithelial cells response Glycoproteins activation, in hepatocytes, 5, 819- to, 1, 863-872 binding to transforming growth factor, 3, 828 nerve. See Nerve growth factor 1295-1307 regulation of, 3, 103-112 neuronal effects of, 1, 511-521 folding of, in endoplasmic reticulum, N- Granules in phosphoinositide hydrolysis induction, linked oligosaccharides in, 5, 253- platelet, factors affecting secretion from, 1, 615-620 265 1, 1027-1041 platelet-derived. See Platelet-derived receptors for, in endocytosis, 1, 471-486 secretory, of AtT-20 cells, localization of, growth factor viral, transport of, microtubule rab proteins in, 4, 747-756 transforming. See Transforming growth perturbation in, 1, 921-936 Granulocyte-macrophage colony- factor(s) Glycosaminoglycans stimulating factor vascular endothelial, isoforms of, 4, effects on gene expression in vascular in bone marrow cultures, macrophage 1267-1275 smooth muscle cells, 1, 435-443 inflammatory proteins produced by, in vascular smooth muscle cell sulfated, transport during mitosis, 1, 415- 2, 403-412 stimulation, 1, 821-831 424 genes of, in T cells, calcineurin activation in vinculin gene expression induction, 1, Glycosomes, Trypanosoma brucei, luciferase of, 5, 119-128 621-636 import into, 3, 749-759 in receptor expression transregulation, in Growth hormone(s) Glycosylation myeloid cells, 3, 535-544 plant, in deepwater rice growth, 1- defective, in endothelial cells, response to receptor for aminocyclopropane-1-carboxylate transforming growth factor-beta, 4, characterization of, 1, 327-335 synthase gene expression and, 4, 135-144 in early response gene activation, 4, 363-373 of lysosomal associated membrane 983-992 transport during mitosis, 1, 415-424 proteins, 4, 627-635 GRB2 protein Growth hormone-releasing factor replacing Caenorhabditis elegans sem-5 in cAMP synthesis, 3, 123-128 of N-linked oligosaccharides, 5, 253-265 gene, 4, 1175-1188 gmal2 gene gro gene expression GRP78-BiP (glucose-regulated/Ig heavy- localization of, in Schizosaccharomyces in inflammation, 2, 739-752 chain binding protein) pombe Golgi apparatus, 5, 519-528 GroEL proteins gene of, regulation of, 3, 143-155 GMP-140 (P-selectin, CD62, PADGEM) interactions with mitochondrial proteins, GTP. See Guanosine triphosphate cytoplasmic domain of, in sorting into 2, 165-179 GTPase(s) regulated pathway of secretion, 3, Growth ADP-ribosylation factors as, in Golgi 309-321 arrest of, in Schizosaccharomyces pombe, transport, 5, 237-252 GMPCPP (guanylyl-(a,fl)-methylene- mammalian protein kinase C dynamin as, 3, 1181-1194 diphosphonate) isotypes and, 5, 907-920 ras-related in microtubule assembly, 3, 1155-1167 inhibition of, signal transduction for, 4, in actin cytoskeleton organization, 3, Golgi apparatus 135-144 475-479 calcium-ATPase homologue (PMR1) of Saccharomyces cerevisiae, inhibition of, activation of, 3, 1437-1442 localization in, 3, 633-654 aberrant phosphorylation in, 5, 283- GTPase activating protein endoplasmic reticulum transport to 296 in cytoskeleton organization, 3, 475-479 disruption of, coat protein Growth factors of Ras accumulation in, 4, 413-424 antiproliferative function of, 1, 741-746 platelet-derived growth factor receptor of immunoglobulin G, 5, 1311-1324 connective tissue, regulation in wound binding to, 4, 49-57 inhibition of, binding protein repair, 4, 637-645 tyrosine phosphorylation of, 2, 413- relocalization in, 5, 1119-1127 in endothelin-specific transcript 425 enzymes associated with, influenza virus induction, 1, 649-659 in ras GTPase activation, 3, 1437-1442 hemagglutinin modification by, 2, epidermal. See Epidermal growth factor rasl regulation by, in Schizosaccharomyces 549-563 in epidermal growth/differentiation, 1, pombe, 2, 453-465 function of, ADP-ribosylation factors in, 791-809 tyrosine phosphorylation of, 2, 73-85 5, 237-252 in epithelial-mesenchymal transition, 1, GTP*gammaS giantin in, characteristics of, 4, 679-693 975-988 in recruitment into coated pits, 4, 715- localization signal for, in yeast, disruption extracellular regulation of, 3, 1057-1065 727 of, 3, 1353-1371 fibroblast. See Fibroblast growth factor N-(2-Guanidinoethyl)-5- lysosomal associated membrane protein in gene activation, in FOS-expressing isoquinolinesulfonamide (HA-1004) transit through, 4, 627-635 cells, 1, 347-357 in ADR induction, 1, 1015-1025 prion protein synthesis and, 3, 851-863 in gene regulation, interferon suppression Guanine nucleotide(s) protein delivery from, Brefeldin A effects of, 1, 215-226 in phospholipase D activation, 2, 1011- on, 4, 93-105 heparanase activity and, 1, 833-842 1019 protein retention in, polar residues in, 4, in inositol polyphosphate formation, 5, in platelet granule secretion, 1, 1027- 695-704 17-27 1041

1380 Molecular Biology of the Cell Subject Index

Guanine nucleotide-binding regulatory HAl cells U3 snRNA-containing bodies in, 5, proteins. See G proteins integrin receptor focal contact localization 955-966 Guanine 5'-O-(2-thiodiphosphate) in, 4, 593-604 small nuclear ribonucleoprotein particle in phosphoinositide hydrolysis, 1, 615- Halothane localization in, 3, 555-569 620 as intracellular communication blocker, 1, spreading of, arachidonic acid Guanine 5'-O-(3-thiotriphosphate) 585-596 metabolites in, 3, 481-492, 4, 271- in phosphoinositide hydrolysis, 1, 615- Hamster 281 620 mitogen-activated protein kinases of, transferrin receptor nuclear proteins Guanine triphosphate activation of, 3, 63-71 from, 1, 151-165 in signal recognition particle activity, 5, Hansenula polymorpha Helper T cells 887-897 alcohol oxidase assembly in, flavin mouse, interleukin-2 receptor Guanosine 5'-thiotriphosphate adenine dinucleotide requirements phosphorylation and, 2, 73-85 in endosome fusion, 1, 113-124 in, 5, 829-837 type II, interleukin-4 gene expression in exocytosis, 1, 337-346, 1, 523-530 Ha-ras transformed mouse mammary regulation in, 1, 425-434 in fertilization, 2, 121-133 epithelial cells Hemagglutinin, influenza in phospholipase D activation, 2, 1011- syndecan-1 translational expression in, 4, transport of, microtubule perturbation in, 1019 849-858 1, 921-936 in platelet granule secretion, 1, 1027- H2AvD histone variant trimers and monomers of, distribution in 1041 in Drosophila, 3, 593-602 brefeldin A-treated cells, 2, 549-563 Guanosine triphosphate H2A.Z protein Hemagglutinin 9-residue peptide chimeric analogues of in Drosophila, 3, 593-602 kinase in crosslinking of IgE receptor with Healing activation of, 3, 63-71 membrane skeleton, 2, 181-191 fibroblast collagen receptors and, 2, Hemagglutinin-neuraminidase glycoprotein in phospholipase D activation, 2, 1011- 1035-1044, gro gene expression in, 2, GRP78-BiP (heat shock protein) effects 1019 739-752 on, 3, 143-155 in signal transduction, 2, 627-640 hemidesmosomes function in, 2, 427-438 Hematogenous metastasis in crosslinking of IgE receptor with heparanase activity in, 1, 833-842 tumor cell integrins in, 2, 347-355 membrane skeleton, 2, 181-191 myosin dynamics in, 4, 819-836 Hematopoietic cells hydrolysis of, microtubule assembly and, of skin, connective tissue growth factor messenger RNA in, 2, 403-412 3, 1155-1167 gene expression in, 4, 637-645 proliferation of, immunophilin ligands in phosphoinositide hydrolysis, 1, 615- urokinase plasminogen activator in, 1, effects on, 3, 981-987 620 843-852 Heme in Rac proteins, NADPH oxidase activity Heart in guanylyl cyclase structure, 5, 4 and, 4, 1217-1223 cells of Hemidesmosomes Guanylyl cyclase rat, drug bindings sites on, 3, 613-619 cytoskeleton of, integrin interaction with, activation of, inhibition of, 3, 735-747 vascular permeability factor expression 4, 871-884 receptors for, 5, 1-5 in, 3, 211-220 integrin function in, 2, 427-438 Guanylyl-(a,/3)-methylene-diphosphonate connexins in, 4, 7-20 Hemopoietic cells in microtubule assembly, 3, 1155-1167 embryonic development of, signal granulocyte-macrophage colony- Guinea pig cells transduction in, 1, 301-313 stimulating factor receptor in, 1, vascular permeability factor expression infarcted, transforming growth factor-a-1 327-335 in, 3, 211-220 mRNA in, 2, 241-249 Heparan sulfate murine, transforming growth factor-,B1 in myoblast-thrombospondin-1 adhesive in, 2, 467-477 interactions, 5, 423-437 myocytes in, growth factor for, 2, 1081- proteoglycans of 1095 syndecan 4 heparan sulfate, in focal H-7 (1-(5-isoquinolinylsulfonyl)-2- Heat shock protein(s) adhesion, 5, 183-192 methylpiperazine) eukaryotic proteins similar to, 4, 1145- syndecans of, selective expression of, 5, in ADR induction, 1, 1015-1025 1159 797-805 in amphibian egg activation, 1, 315-326 genes of Heparanase basic fibroblast growth factor mitogenic expression in Caenorhabditis elegans, 3, in fibroblast growth factor release, 1, activity and, 2, 719-726 221-233 833-842 in embryonic heart development, 1, 301- regulation of, 3, 143-155 Heparin 313 interactions with mitochondrial proteins, brain calcium uptake and, 1, 781-790 in interleukin-4 gene expression, 1, 425- 2, 165-179 in calcium release channel activation, 4, 434 70-kD, Escherichia coli dnaJ homologues 347-352 nuclear factor kappa B activation and, 2, function with, 4, 555-563 cyclic adenosine diphosphate-ribose 329-335 PBP74 as, characterization of, 5, 1265- action and, 1, 279-290 as protein kinase inhibitor, in tumor cell 1275 effects on gene expression in vascular adhesion, 2, 1045-1055 synthesis of, regulation of, 1, 135-149 smooth muscle cells, 1, 435-443 H-8 (N-[(2-methylamino)ethyl]-5- Heat shock protein 60 interaction with neural cell adhesion isoquinoline sulfonamide import into mitochondria, ATP molecule, 1, 567-576 dehydrochloride) requirements for, 5, 465-474 in prostate cancer cell stimulation, in ADR induction, 1, 1015-1025 Heat-shock loci, Drosophila B52 protein amphiregulin expression and, 5, H-89 distribution on, 5, 71-79 339-347 in calcium influx to T lymphocytes, 4, HeLa cells signal transducing mechanisms of, 4, 173-184 calcium regulation in, 2, 915-925 135-144 HA-1004 (N-(2-guanidinoethyl)-5- cell cycle of, p34cdc2 regulation in, 5, 989- thrombospondin-transforming growth isoquinolinesulfonamide) 1001 factor binding and, 3, 181-188 in ADR induction, 1, 1015-1025 nucleogenesis in in vascular endothelial growth factor

Vol. 5, December 1994 1381 Subject Index

release from extracellular matrix, 4, Hirudin calcium role in, 2, 27-39 1267-1275 as thrombin inhibitor, in diacylglycerol chloride/bicarbonate exchange regulation Heparin binding-epidermal growth factor regulation, 2, 311-316 in, 2, 727-737 extracellular regulation of, 3, 1057-1065 Histamine Hydrogen ion-ATPase complex assembly Heparin-binding domain of fibronectin calcium ion changes vs. catecholamine in Saccharomyces cerevisiae, vma21 peptide related to, in cell adhesion, 4, release and, 1, 683-691 membrane protein in, 5, 1039-1050 605-613 in calcium ion regulation, 2, 915-925 Hydrolysis Heparin-binding growth factor in gastric acid secretion of phosphatidylcholine, receptor- macrophage-derived, characterization of, agonists interaction with, 2, 27-39 dependent, 2, 299-303 1, 811-819 chloride/bicarbonate exhange and, 2, Hydrophobic sites nonmyocyte-derived, in myocyte growth 727-737 on calcium mediator proteins, 1, 167-168 modulation, 2, 1081-1095 Histone 25-Hydroxycholesterol Heparin-binding growth-associated variant of, in Drosophila, 3, 593-602 insulin resistance affected by, 2, 65-72 molecule Histone Hi 8-Hydroxy-di-(n-propyl)aminotetralin characterization of, 3, 85-93 phosphorylation of, 4, 669-677 in DNA synthesis, serotoninlA receptor Hepatocytes Histone Hi kinase activation and, 3, 961-969 asialoglycoprotein receptor activity in, cyclin binding to, 3, 1279-1294 12(S.)-Hydroxyeicosatetraenoic acid fatty acyl-coenzyme A regulation of, in metaphase spindles, 2, 861-874 in tumor cell adhesion modulation, 2, 5, 227-235 HIT-T15 cells 1045-1055 calcium ion oscillation in, 1, 853-861 insulin secretion in, actin filament role in, Hydroxymethylglutaryl CoA reductase growth of, integrin binding and cell 5, 1199-1213 domain-histidinol dehydrogenase spreading effects on, 5, 967-975 HL-60 cells chimera jak2 kinase activation in, interleukin-6 in, small nuclear ribonucleoprotein particle assembly of, sec genes in, 3, 129-142 5, 819-828 localization in, 3, 555-569 in liver gene regulation study, fetal vs. HNF1 3-Hydroxy-3-methylglutaryl coenzyme A adult, 4, 59-69 inefficient function of, in hepatoma cells reductase feedback murine, transforming growth factor-,81 of fetal phenotype, 4, 59-69 in Saccharomyces cerevisiae, regulation of, in, 2, 467-477 H-ras proteins 5, 655-665 rat effector functions of, Raf-1 protein kinase 13(S)-Hydroxyoctadecadienoic acid cytokine receptor regulation in, 3, 103- interference with, 5, 135-145 in tumor cell adhesion modulation, 2, 112 Hrr25 protein 1045-1055 hormone-induced calcium signal of Saccharomyces cerevisiae, activity of, 5, Hydroxyurea coordination in, 3, 113-121 877-886 sensitivity to, Schizosaccharomyces pombe transforming growth factor-,B effects on, hspl6 genes stsl+ gene in, 3, 263-273 2, 535-548 expression in Caenorhabditis elegans, 3, Hyperrecombination tubulin monomer levels in, extracellular 221-233 of mcml-11OL gene, 3, 97X-980 matrix control of, 5, 1277-1280 HSSI gene Hypersensitive sites Hepatoma cells in yeast endoplasmic reticulum protein of globin genes, for correct expression, 4, lipid-induced insulin resistance in, 2, 65- translocation, 4, 919-930 1077-1085 72 HT 1080 fibrosarcoma cells Hypertension mitogen-activated protein kinases of, vascular permeability factor expression platelet-derived growth factor in, 1, 167- immunologic characterization of, 3, in, 3, 211-220 168 775-787 HT-29 cells Hypoxia rat, connexin43 gene transcription calcium-ion-stimulated chloride in rice plants, 1-aminocyclopropane-1- regulation in, 3, 839-850 conductance in, 1, 951-963 carboxylate synthase gene expression HepB2 (hepatoma) cell line Human cell-cycle gene 1 and, 4, 363-3.73 in liver gene regulation.study, fetal vs. cDNA of, 3, 761-773 adult, 4, 59-69 Human immunodeficiency virus her-12 gene gene expression in in Caenorhabditis elegans sex nuclear factor kappa B effects on, 2, ICAM-1 (intercellular adhesion molecule-1) determination, 3, 461-473 329-335 endothelial cell activation by, tumor cell Herbimycin transcriptional attenuation in, 4, 661- adhesion and, 2, 347-355 in early response gene activation, 4, 983- 668 Ideas 992 receptor for, modulation by bryostatin, 2, Heterokarynon myotubes 95-103 on experimentation, essay on, 3, 385-388 dystrophin expression in, 4, 963-972 Human immunodeficiency virus type 1 Ig. See Immunoglobulin Heterotrimeric G proteins *kappaB enhancer, 3, 1339-1352 I*kappaB/MAD-3 complex in membrane traffic, 3, 1317-1328 Human umbilical vein endothelial cells in nuclear factor kappa B localization Hhpl and Hhp2 vascular endothelial growth factor signal masking, 3, 1339-1352 of Schizosaccharomyces pombe, activity of, stimulation in, epidermal growth Immediate early genes 5, 877-886 factor in, 4, 121-133 induction of, neurokinin receptors in, 2, High copy suppressor protein HUT 102B2 cells 767-779 in yeast endoplasmic reticulum protein interleukin-2 receptor phosphorylation in kidney, after ischemia and reperfusion, translocation, 4, 919-930 and, 2, 73-85 2, 251"..260 High-affinity nerve growth factor receptor, Hyaluronic acid Immortalizatibn 2, 685-690 effects on gene expression in vascular of keratinocytes, cell cycle control protein Hippocampus smooth muscle cells, 1, 435-443 levels in, 4, 185-194 protein kinases of, autophosphorylation Hydrochloric acid secretion from parietal small nuclear ribonucleoprotein particle of, 4, 159-172 cells localization in, 3, 555-569

1382 Molecular Biology of the Cell Subject Index

Immunity cytokine receptor regulation in, 3, 103- cation channel sensitive to, 5, 485-496 major histocompatibility complex 112, gro gene expression in, 2, 739- in DNA synthesis molecules in, 1, 499-509 752 muscarinic acetylcholine receptor Immunoaffinity chromatography, heparanase activity in, 1, 833-842 activation effects on, 2, 373-381 Drosophila centrosomal protein macrophage inflammatory proteins in, 2, serotoninlA receptor activation and, 3, purification by, 3, 1-11 403-412 961-969 Immunocytochemistry platelet-derived growth factor in, 1, 559- extracellular signal-regulated kinase in small nucleolar ribonucleoproteins 560 activity and, 2, 357-371, 3, 299-308 organization characterization, 5, Influenza hemagglutinin in mitogen-activated protein kinase 1289-1299 transport of, microtubule perturbation in, activation, in NIH-3T3 cells, 4, 483- Immunoelectron microscopy 1, 921-936 493 in Saccharomyces cerevisiae cell cycle, 3, trimers and monomers of, distribution in neurite response to, in retinoic acid- 789-803 brefeldin A-treated cells, 2, 549-563 treated neuroblastoma cells, 2, 1021- Immunofluorescence, indirect INH protein phosphatase type 2A 1033 in visualization of Gi protein in a in cdc2 kinase inhibition, 5, 323-338 receptors for, endocytosis of, kinase- subunit(s) subcellular distribution, 2, Inheritance dependent, 5, 539-547 1097-1113 mitochondrial, in yeast, 4, 21-36 resistance to, in hepatoma cells, lipid- Immunoglobulin(s) Initiation factors induced, 2, 65-72 glucose-regulated stress protein binding in meiosis, cell-free translation system secretion of, actin filaments in, 5, 1199- to, in endoplasmic reticulum, 4, for, 1, 1057-1067 1213 1109-1119 Injury in Xenopus laevis oocytes, vanadate kappa gene expression of, nuclear factor SpCoell gene expression in, 3, 403-414 effects on, 2, 317-327 kappa B effects on, 2, 329-335 Inositides Insulin-like activity Immunoglobulin E receptors brain calcium uptake and, 1, 781-790 of vanadate, in Xenopus laevis oocytes, 2, in actin polymerization, 5, 313-322 Inositol phosphates 317-327 crosslinking with membrane skeleton, 2, in DNA synthesis, 1, 445-451 Insulin-like growth factors 181-191 production of in cyclin D mRNA expression regulation, in phosphatidylcholine hydrolysis, 2, carbachol effects on,.2, 383-390 4, 1133-1144 299-309 epidermal growth factor in, 1, 615-620 DNA synthesis induction by, muscarinic in signal transduction, isoprenoid in T-cell activation, 2, 841-850 acetylcholine receptor activation pathway activity in, 2, 627-640 Inositol phospholipids effects on, 2, 373-381 Immunoglobulin G hydrolysis of, protein kinase C**sub extracellular regulation of, 3, 1057-1065 endoplasmic reticulum-to-Golgi transport gamma inhibition of, 5, 475-484 in neuronal differentiation, 3, 545-553 of, 5, 1311-1324 Inositol polyphosphates in urokinase-type plasminogen activator Immunoglobulin gene superfamily formation of, factors affecting, 5, 17-27 expression, 2, 285-297 cDNA of, 3, 761-773 Inositol triphosphate in vascular smooth muscle cell Immunoglobulin M analogues of, calcium oscillations and, 1, stimulation, 1, 821-831 crosslinking of, lyn gene products in, 2, 675-681 in Xenopus laevis oocytes, vanadate 979-987 brain calcium uptake and, 1, 781-790 effects on, 2, 317-327 Immunogold labeling calcium ion'mobilization by, 1, 279-290 Integration host factor in visualization of G, protein in. a calcium oscillations and, 1, 853-861 in Caulobacter crescentus cell cycle, 3, subunit(s) subcellular distribution, 2, in calcium release, platelet-activating 913-926 1097-1113 factor-induced, 2, 513-522 Integrin(s) Immunophilin(s) in epithelial intercellular communication, activation of, 1, 883-893 cross-linking to non-proline-containing 1, 585-596 affinity modulation'of, 1, 883-893 peptide, 4, 223-232 formation of, neurokinin receptors in, 2, binding of, in hepatocyte growth, 5, 967- Immunophilin ligands 767-779 975 hematopoietic cells proliferation and, 3, profilin affinity for, 1, 937-950 as cell survival factors, 4, 953-961 981-987 stimulation of, in sea urchin eggs, in chicken embryo fibroblasts, Rous Immunosuppressive drugs guanosine 5'-thiotriphosphate in, 2, sarcoma virus effects on, 2, 271-283 hematopoietic cell line proliferation 121-133 as collagen receptors, 2, 1035-1044 inhibition by, 3, 981-987 Inositol 1,4,5-trisphosphate in colon carcinoma cell adhesion, 1, 249- IMR32 neuroblastoma cells in calcium channel gating, caffeine effects 257 retinoic acid differentiation of, integrin on, 5, 97-103 expression of, modulation of, basic expression and, 2, 1021-1033 in calcium mobilization, calcium pool fibroblast growth factor in, 4, 973- INCAM-110 (inducible cell adhesion localization and, 3, 613-619 982 molecule 110) mass changes in, in Xenopus egg fibronectin interaction with, protein (120- endothelial cell activation by, tumor cell fertilization, 4, 435-443 kDa) phosphorylation induced by, 2, adhesion and, 2, 347-355 in sea urchin egg activation, 3, 373-383 951-964 Indoleacetic acid Inositol 1,4,5-trisphosphate 3-kinase functional determinants mapping of, 1, 1-aminocyclopropane-1 -carboxylate overexpression of, in growth factor- 597-604 synthase gene expression and, 4, stimulated fibroblasts, 5, 17-27 hemidesmosome cytoskeleton interaction 363-373 Insects with, 4, 871-884 Indomethacin prothoracic glands of, calmodulin- integrating functions of, 5, 389-393 cyclic AMP production and, 2, 13-25 dependent adenylate cyclase activity leukocyte, expression on Inducible cell adhesion molecule 110 in, 1, 771-780 nonhematopoietic cell line, 1, 359- endothelial cell activation by, tumor cell pupation of, Sciara puff gene promoters 367 adhesion and, 2, 347-355 and, 2, 875-888 in myoblast-thrombospondin-1 adhesive Inflammation Insulin interactions, 5, 423-437

Vol. 5, December 1994 1383 Subject Index

osteopontin binding of, 3, 1169-1180 receptor for, proteolysis of, 1, 907-919 of cytochrome c reductase, import into overexpression in K562 cell variants, 1, receptor for, tyrosine phosphorylation of, mitochondria, ATP requirements for, 637-648 2, 73-85 5, 465-474 platelet, in cell spreading, 3, 989-998 transcription of, immunosuppressive Ischemia polarization of, on retinal pigment drugs effects on, 3, 981-987 kidney, immediate early growth response epithelium, 2, 939-949 Interleukin-4 gene in, 2, 251-260 receptors for, focal contact localization of, gene expression regulation of, in T helper Isethionate 4, 593-604 cells, 1, 425-434 in exocytosis from mast cells, 1, 337-346 1215-1223 Interleukin-6 ISG54 gene Integrin a,#, in Jak2 kinase activation, in hepatocytes, RNA polymerase mapping on, 3, 1085- up-regulation of, in retinoic acid- 5, 819-828 1094 differentiated neuroblastoma cells, 2, receptor for, regulation of, 3, 103-112 ISG-54K gene expression 1021-1033 Intermediate filaments interferon-induced, down regulation of, Integrin a2 phosphorylation effects on, 1, 237-248 1, 707-713 adhesive activity of, focal adhesion Internalization Isobutyl methylxanthine formation and, 5, 977-988 of CR1, in neutrophils, 2, 41-55 cyclic AMP production and, 2, 13-25 Integrin a2f1 of transferrin receptor, 1, 369-377 effects on angiotensin II-induced tubular collagen receptor for, 2, 905-913 Interphase cells epithelial hypertrophy, 2, 219-227 Integrin a3A01 calcium ion regulation in, 2, 915-925 leukocyte integrin activity on ligand specificity of, 5, 203-215 Intracellular communication nonhematopoietic cells and, 1, 359- Integrin a4#1 calcium ion in, 1, 585-596 367 on tumor cell surfaces, adhesion to Intracellular particles sodium metabolism and, 1, 259-268 vascular endothelium, 2, 347-355 movement of, 1, 3-4 Isoprenaline Integrin a6/1 Intracellular vesicles cyclic AMP production and, 2, 13-25 structural variants of, in macrophage localization of, rab proteins in, 4, 747- Isoprenoid pathway migration modulation, 5, 679-690 756 in signal transduction, 2, 627-640 Integrin a6#4 Intrasynaptic mitochondria 1-(5-Isoquinolinesulfonyl)-2- in hemidesmosomes, 2, 427-438 cytosolic free calcium regulation by, 3, methylpiperazine (H-7) Integrin a731 235-248 basic fibroblast growth factor mitogenic laminin binding of, in melanocytes, 2, Invasiveness activity and, 2, 719-726 805-817 of melanoma, nerve growth factor in, 4, nuclear factor kappa B activation and, 2, Integrin jB1 1205-1216 329-335 cytoplasmic domain of, adhesive lodoacetamide as protein kinase inhibitor, in tumor cell properties of, lysophosphatidic acid as protease inhibitor, in T-cell receptor adhesion, 2, 1045-1055 effects on, 5, Intercellular adhesion chain degradation studies, 2, 753- 1-(5-Isoquinolinylsulfonyl)-2- molecule-1 765 methylpiperazine. See H-7 endothelial cell activation by, tumor cell Ion channels ITTR gene adhesion and, 2, 347-355 insulin-sensitive, 5, 485-496 RNA polymerase mapping on, 3, 1085- leukocyte integrin binding to, in Ionomycin 1094 nonhematopoietic cells, 1, 359-367 in calcium inhibition, cell cycle effects of, Interferon(s) 4, 293-302 antiproliferative effects of, 1, 215-226 in calcium ion-stimulated chloride in gene expression, down regulation of, 1, conductance in epithelial cells, 1, J774 macrophage-like cells 707-713 951-963 anthrax lethal toxin effects on, 3, 1269- in macrophage cytocidal activation, in crosslinking of IgE receptor with 1277 calcium ion in, 3, 335-347 membrane skeleton, 2, 181-191 Jak2 kinase Interferon-gamma in gastric acid secretion, 2, 27-39 in hepatocytes, activation of, with nuclear factor kappa B activation and, 2, in interleukin-4 gene expression, 1, 425- interleukin-6, 5, 819-828 329-335 434 JAR cells signal transducing mechanisms of, 4, in intracellular calcium release, 2, 513- plasminogen activator degradation in, 1, 135-144 522 1043-1056 Interleukin(s) in macrophage cytocidal activation, 3, jun-B gene in gene activation in FOS-expressing 335-347 transcriptional regulation of, 1, 347-357 cells, 1, 347-357 Ipsaspirone jun-D gene in urokinase-type plasminogen activator in DNA synthesis, serotoninlA receptor transcriptional regulation of, 1, 347-357 expression, 2, 285-297 activation and, 3, 961-969 Jurkat cells Interleukin-1 IRA genes calcium influx to, 4, 173-184 in cytokine receptor regulation, 3, 103- expression of, in Saccharomyces cerevisiae mitogen-induced calcium ion oscillations 112 growth arrest, 4, 757-765 in, 1, 99-112 in nuclear factor kappa B activation, 2, Iron phosphorylation in, ultraviolet radiation 329-335 metabolism of, transferrin receptor induction of, 4, 523-530 Interleukin- 1 a activity in, 1, 369-377 stimulated, in phospholipase D signal transducing mechanisms of, 4, Iron (II) activation, 2, 841-850 135-144 in actin reorganization, 2, 1067-1079 Interleukin-2 Iron-responsive element binding protein, 4, genes of, in T cells, calcineurin activation 1-5 of, 5, 119-128 Iron-sulfur clusters K562 cell variants production of, bryostatin effects on, 2, in aconitase, 4, 1-5 fibronectin receptor overexpression in, 1, 95-103 Iron-sulfur protein 637-648

1384 Molecular Biology of the Cell Subject Index

K1735 melanoma cells Kit ligand signal transduction in, isoprenoid laminin of, integrin binding to, 2, 805- cleavage of, control of, 5, 943-953 pathway activity in, 2, 627-640 817 KL-1 and KL-2 (kit ligands) Leukemic human T lymphoblastoid cells K252a expression of, 3, 349-362 activator of DNA replication induction in, in crosslinking of IgE receptor with KT5720 1, 1015-1025 membrane skeleton, 2, 181-191 in calcium influx to T lymphocytes, 4, Leukocyte integrins K-252a kinase inhibitor 173-184 expression on nonhematopoietic cell line, in neurotrophin receptor lacZ reporter gene 1, 359-367 autophosphorylation, 3, 677-686 expression of, in cell cycle, 3, 1095-1105 Leupeptin Kalinin proteolysis rate and, 1, 907-919 integrin adherence to, 5, 203-215 Lewis X determinant Kar2 protein in LEC mutants, a(1,3)fucosyltransferase interactions with Sec63 protein, in yeast Lamin B receptor activity and, 2, 989-1000 endoplasmic reticulum, 4, 1145-1159 chicken, vs. Schizosaccharomyces pombe Ligand(s) Karyokinesis stsl+ gene product, 3, 263-273 of cAMP receptors, binding of, second mechanisms of, 1, 4 Laminin messenger regulation of, 3, 603-612 KB carcinoma cells colon carcinoma cells adhesion to, 1, Ligand-binding specificity multidrug resistance chromosomes 249-257 of epidermal growth factor, 2, 337-345 generated from, 3, 507-520 endothelial cell adhesion to, basic of mutant epidermal growth factor KDEL-bearing proteins fibroblast growth factor effects on, 4, receptors, 1, 173-188 in endoplasmic reticulum, 3, 1067-1072 973-982 Light chains Keratinocyte(s) in fibronectin/integrin interactions of clathrins, alteration of, 4, 647-660 growth factor effects on, 1, 791-809 studies, 2, 951-964 LIM 1215 cells growth factor ligand-receptor binding in, integrin binding to, in melanocytes, 2, proliferation of, inhibition by 2, 599-612 805-817 transforming growth factor-a proliferation of, transforming growth isoforms of, recognition of, 5, 203-215 oligonucleotides, 3, 1235-1243 factor-a in, 2, 613-625 mRNA for, expression of, transforming lin-15 gene retinoic acid effects on, 1, 87-97, 1, 791- growth factor-,B effects on, 2, 535- in vulval development regulation, in 809, 1, 965-973 548 Caenorhabditis elegans, 5, 395-412 spontaneous immortalization of, cell cycle neurite response to, in retinoic acid- Linoleic acid control protein levels in, 4, 185-194 treated neuroblastoma cells, 2, 1021- insulin resistance affected by, 2, 65-72 urokinase plasminogen activator 1033 metabolites of, in tumor cell adhesion receptors on, 1, 843-853 polarized distribution of integrins modulation, 2, 1045-1055 Keratinocyte growth factor stimulated by, 2, 939-949 Lipid A in epithelial-mesenchymal transition, in receptor for, a6fl1 integrin structural in tumor necrosis factor release, rat bladder carcinoma cells, 5, 851- variants interactions with, in membrane potential modulation of, 862 macrophage functional modulation, 3, 451-460 Kex2 protease 5, 679-690 Lipocortins (annexins), 1, 166, 1, 168 yeast, tyrosine localization signal in, variants of, distribution of, 1, 731-740 Lipopolysaccharides disruption of, 3, 1353-1371 Lampbrush chromosome loops in nuclear factor kappa B activation, 2, Kidney transcription on, small nuclear RNA 329-335 ischemia and reperfusion of, immediate effects on, 3, 249-261 in tumor necrosis factor release, early growth response gene in, 2, Latency membrane potential modulation of, 251-260 vs. oscillation of cytosolic calcium ion, 1, 3, 451-460 osteopontin in, 3, 1169-1180 853-861 Lipoprotein cholesteryl ester metabolism vascular permeability factor expression LEC mutants of Chinese hamster ovary lysosomal acid lipase in, 1, 661-674 in, 3, 211-220 cells Lipoxygenase metabolites, of arachidonic Kidney cells a(1,3)fucosyltransferase activity in, 2, acid carcinoma, adhesion to vascular 989-1000 in HeLa cell spreading on collagen, 3, endothelium, 2, 347-355 Lectins 481-492 fibroblasts, G, protein in, a subunit(s) of, calnexin properties resembling, 5, 253- in tumor cell adhesion modulation, 2, subcellular distribution of, 2, 1097- 265 1045-1055 1113 resistance to, of Chinese hamster ovary Listeria monocytogenes Madin-Darby canine LEC mutants, 2, 989-1000 endothelial cell invasion by, mitogen- polarized, TGN38 protein recycling in, Lens fiber protein MP70 activated protein kinase 5, 1093-1103 mouse gap junction Cx5O protein phosphorylation in, 5, 455-464 in syndecan-1 cytoplasmic tail deletion identified as, 3, 711-720 Lithium chloride studies, 5, 1325-1339 Leukemia 1 -aminocyclopropane-1 -carboxylate rat, nucleogenesis in, U3 snRNA- proteins implicated in, similarity to Ancl synthase gene expression and, 4, containing bodies in, 5, 955-966 protein of Saccharyomyces cerevisiae, 363-373 tubular epithelial, angiotensin II-treated, 5, 617-632 Liver collagen secretion from, 2, 219-227 Leukemia cells cells of, vascular permeability factor kin 1 gene interleukin-2 receptor phosphorylation expression in, 3, 211-220 mutation of, in Schizosaccharomyces and, 2, 73-85 murine, transforming growth factor-fit pombe, 5, 613-616 mitogen-induced calcium ion oscillations in, 2, 467-477 Kinases. See Protein kinase(s); Tyrosine in, 1, 99-112 regeneration of, transforming growth kinase(s) plasminogen activation in, alpha2- factor-# isoforms in, 2, 535-548 Kinetochores macroglobulin effects on, 2, 1057- transcription factors in, fetal vs. adult, 4, spindle proteins in, 2, 861-874 1065 59-69

Vol. 5, December 1994 1385 Subject Index

LLC-PKI (porcine kidney epithelial) cells in integrin #1 adhesive properties study, in syndecan-1 cytoplasmic tail deletion protein kinase C overexpression in, 5, 1215-1223 studies, 5, 1325-1339 effects of, 2, 491-502 Lysosomal acid lipase viral glycoprotein transport in, Localization in cholesteryl ester metabolism, 1, 661- microtubule perturbation and, 1, of calcium, after mobilization, 3, 621-631 674 921-936 nuclear factor kappa B signals for, Lysosomal associated membrane proteins Magnesium ATP masking of, 3, 1339-1352 polylactosamine glycosylation of, 4, 627- in phospholipase D activation, 2, 1011- of nuclear proteins, in Saccharomyces 635 1019 cerevisiae mutant, 3, 875-893 Lysosomal enzymes Magnesium ion signals for, in yeast, disruption of, 3, in insulin-like growth factor II bonding, in mobilized calcium localization, 3, 613- 1353-1371 1, 196-213 619 of small nuclear ribonucleoprotein in receptor-bound plasminogen activator in phospholipase D activation, 2, 1011- particles, in transformed and degradation, 1, 1043-1056 1019 nontransformed cells, 3, 555-569 Lysosomes in platelet adhesion/activation, 2, 905- Locus control region selectins in, 4, 791-801 913 of globin genes, hypersensitive sites on, Lysostearoyl phosphatidate sensitivity to, Schizosaccharomyces pombe 4, 1077-1085 mitogenic activity of, 2, 57-64 stsl+ gene in, 3, 263-273 Lovastatin Lytechnus pictus eggs Major histocompatibility complex molecules as isoprenoid pathway inhibitor, in pore formation in, 1, 65-74 in antigen processing, 499-509 immunogloblin E receptor-mediated Malignant transformation signal transduction, 2, 627-640 syndecan-1 translational expression in, 4, Low-affinity nerve growth factor receptor, 849-858 2, 685-690 M40 cell line Mammary epithelial cell culture Luciferase glycosylation-deficient, response to whey acidic protein expression in, 1, 45- import of, into Trypanosoma brucei transforming growth factor-beta, 4, 54 glycosomes, 3, 749-759 135-144 Manganese ion Luminal bodies Mac-1 in actin reorganization, 2, 1067-1079 in endoplasmic reticulum, 3, 1067-1072 expression on nonhematopoietic cell line, in calcium influx to T lymphocytes, 4, Lung carcinoma 1, 359-367 173-184 cell cycle inhibition of, acetylcholine a-Macroglobulin sensitivity to, Schizosaccharomyces pombe receptor activation in, 2, 373-381 secretion by melanoma cells, 1, 895-904 stsl+ gene in, 3, 263-273 Lung cells a2-Macroglobulin Mannose 6-phosphate cancer, binding sites on, for non-opioid in plasminogen activation, in leukemia cholesteryl ester metabolism and, 1, 661- substances, 3, 613-619 cells, 2, 1057-1065 674 vascular permeability factor expression thrombospondin-transforming growth Mannose 6-phosphate/insulin-like growth in, 3, 211-220 factor binding and, 3, 181-188 factor II receptor Lymphoagglutinin Macrophage(s) insulin-like growth factor II binding by, in a(1,3)fucosyltransferase studies, 2, anthrax lethal toxin effects on, 3, 1269- 1, 197-213 989-1000 1277 Mannose receptors Lymphoblasts cytocidal activation of, calcium ion in, 3, 335-347 prostaglandin E effects on, 1, 403-413 of bursa of Fabricius, apoptotic, cell cycle Mannosidases control loss in, 5, 763-772 function of, a6#1 integrin structural variants effects on, 5, 679-690 influenza virus hemagglutinin Lymphocyte(s). See also B cell(s); T cell(s) heparin-binding growth factor derived modification by, 2, 549-563 activator of DNA replication induction in, from, 1, 811-819 in virus envelop protein maturation, 1, 1, 1015-1025 mannose receptors on, prostaglandin D 531-541 differentiation of, syndecan in, 1, 27-35 effects on, 1, 403-413 MAP kinases. See Mitogen-activated protein phosphorylation in, ultraviolet radiation platelet-activating factor-stimulated, kinase(s) induction of, 4, 523-530 calcium response of, 2, 513-522 Mapping Lymphocyte function-associated antigen 1 proteins of, 1, 167 of RNA polymerase on mammalian expression on nonhematopoietic cell line, tumor necrosis factor release from, genes, 3, 1085-1094 1, 359-367 membrane potential modulation of, of Saccharomyces cerevisiae chromosome Lymphocyte function-associated antigen 3 3, 451-460 III circular derivative, 3, 999-1013 adhesion efficiency of, 3, 157-166 vascular permeability factor expression MARCKS (myristoylated and alanine-rich Lymphokines in, 3, 211-220 C-kinase substrate) gene expression regulation in T helper Macrophage colony-stimulating factor antibody to, in bradykinin response cells, 1, 425-434 in receptor expression transregulation, in studies, 2, 229-239 Lymphoma cells myeloid cells, 3, 535-544 phosphorylation of, in response to heparanase activity expression by, 1, receptor for, activating mutations effects phorbol esters in cells overexpressing 833-842 on, 5, 81-95 protein kinase C, 3, 1049-1056 virus envelope protein maturation in, Macrophage inflammatory proteins Mas6 protein glucocorticoids in, 1, 531-641 novel expression pattern of, 2, 403-412 in protein import into mitochondria, in lyn gene Macropinocytosis Saccharomyces cerevisiae, 5, 529-538 proteins produced by, 2, 979-987 in CR1 internalization, 2, 41-55 Mast cell(s) Lysooleoyl phosphatidate Madin-Darby canine kidney cells exocytosis mechanisms in, ATP in, 1, mitogenic activity of, 2, 57-64 lysosomal associated membrane protein 337-346 Lysophosphatidate polylactosamine glycosylation in, 4, permeabilized, exocytic mechanisms of, 1, in phosphoinositide hydrolysis, 1, 615- 627-635 523-530 620 polarized, TGN38 protein recycling in, 5, proliferation of, immunophilin ligands Lysophosphatidic acid 1093-1103 effects on, 3, 981-987

1386 Molecular Biology of the Cell Subject Index

receptor-dependent phosphatidylcholine laminin of, integrin binding to, 2, 805- arachidonic acid metabolites in, 2, 1045- hydrolysis in, 2, 299-303 817 1055 Mast cell growth factor nerve growth factor receptor diffusion in, hematogenous, tumor cell integrins in, 2, in melanocyte proliferation, c-kit proto- 1, 605-614 347-355 oncogene role in, 3, 197-209 plasminogen activation on, 1, 895-905 of melanoma Mating, of yeasts Membrane laminin receptors in, 2, 805-817 FAR1 phosphorylation and, 3, 445-450, G protein interaction with, gamma- nerve growth factor in, 4, 1205-1216 FUS3 mutations in, 5, 297-312 subunit prenylation effects on, 3, 49- 6-Methoxy-N-(3-sulfopropyl)-quinolinium pheromone for, in yeast signal 61 in parietal cell chloride/bicarbonate transduction, 1, 391-401 Membrane fraction exchange studies, 2, 727-737 polarization in, extracellular cues in, 5, of Xenopus egg extract, in cdc2 1-Methyladenine 1169-1175 phosphorylation, 5, 273-282 in starfish oocyte maturation, 4, 1027- projection formation in, 3, 429-444, 3, Membrane potential 1034 1025-1035 in tumor necrosis factor regulation, in N-[(2-Methylamino)ethyl]-5-isoquinoline Matrigel lipopolysaccharide stimulation, 3, sulfonamide dehydrochloride (H-8) in polarized distribution of integrins, 2, 451-460 in ADR induction, 1, 1015-1025 939-949 Membrane proteins Methylation Matrix processing peptidase subunit in Caenorhabditis elegans sex of basic fibroblast growth factor arginine import into mitochondria, ATP determination, 3, 461-473 residues, 2, 87-93 requirements for, 5, 465-474 ideas about, essay on, 3, 385-388 5-Methyl-10,11-dihydro-5H- Matrix receptors sorting into regulated pathway of dibenzo[a,b]cyclohepten-5,10-imine steroid-induced suppression of, 2, 1-11 secretion, P-selectin in, 3, 309-321 hydrogen maleate (SKF-10 047) Maturation translocation of, sec genes in, 3, 129-142 biologically active binding sites for, 3, meiotic, cell-free translation system for, 1, Membrane skeleton 613-619 1057-1067 crosslinking with IgE receptor, 2, 181-191 N-Methyl-N'-nitro-N-nitrosoguanidine Maturation-promoting factor Membrane traffic in a(1,3)fucosyltransferase activation, 2, activation of, cdc25 in, 5, 135-145 heterotrimeric G proteins in, 3, 1317- 989-1000 in Xenopus laevis oocytes, vanadate 1328 N-Methylscopolamine effects on, 2, 317-327 Membrane-associated protein kinase muscarinic acetylcholine receptor mcml-l gene in ADR induction, 1, 1015-1025 activation and, 2, 373-381 in DNA synthesis, 3, 971-980 Merosin Mevalonate synthesis MCM2 protein integrin adherence to, 5, 203-215 3-hydroxy-3-methylglutaryl coenzyme A vs. nda gene product, 4, 1003-1015 variants of, distribution of, 1, 731-740 reductase feedback regulation in, 5, mcml-11OL1 gene Mesenchymal cells 655-665 cell cycle arrest in, 3, 971-980 inhibition of, 1, 301-313 MeWo melanoma cells MCT cells Messenger RNA invasiveness of, nerve growth factor in, 4, angiotensin II-treated, collagen secretion cadherin, 2, 261-270 1205-1216 from, 2, 219-227 calmodulin, 2, 819-826 laminin of, integrin binding to, 2, 805- MDR genes in cAMP receptors, second messenger 817 in drug resistance, 3, 507-520 regulation of, 3, 603-612 Mezerein mdx cells endothelin, 1, 649-659 in embryonic heart development, 1, 301- dystrophin expression in, 4, 963-972 in heat-shock protein regulation, 1, 135- 313 Mechanical signaling 149 Microbial peptidyl epoxide E64 integrins in, 5, 389-393 hematopoietic-specific, granulocyte- as protease inhibitor, in T-cell receptor Mechanical stimulation macrophage colony-stimulating chain degradation studies, 2, 753- in epithelial intercellular communication, factor effects on, 2, 403-412 765 1, 585-596 heparin effects on, 1, 435-443 Microfilaments Meiosis interferon effects on, 1, 435-443 protein kinase C translocation to, 1, 693- cell-free translation system for, 1, 1057- interleukin-4, 1, 425-434, lyn gene 706 1067 products, 2, 979-987 Microscopy of starfish oocytes, regulation of, 4, 1295- in meiosis, cell-free translation system confocal, in calcium signal coordination 1306 for, 1, 1057-1067 studies, 3, 113-121 MEK-1 protein kinase for membrane proteins, 1, 453-463 immunoelectron, in Saccharomyces phosphorylation activity of, 5, 193-201 nuclear accumulation of, nucleolar cerevisiae cell cycle, 3, 789-803 Melanocytes fragmentation in, 5, 1253-1263, ras Microsomes adhesion to vascular endothelium, 2, oncogene, effects on oocytes, 1, 543- trypsinized, protein translocation in, 2, 347-355 554, Saccharomyces cerevisiae COX2 851-859 laminin of, integrin binding to, 2, 805- gene, alteration of, 4, 1327-1335 Microtubule(s) 817 transforming growth factor-, actin, structure of, 3, 1309-1315 proliferation of, c-kit proto-oncogene in, expression/activation of, 2, 535-548 assembly of 3, 197-209 in infarcted rat heart, 2, 241-249 GTP hydrolysis in, 3, 1155-1167 terminal differentiation and senescence Metabolic enzymes tau protein and, 3, 1141-1154 in, 5, 497-509 as yeast microtubule-associated proteins, in cytoskeleton formation, in Melanoma 3, 29-47 Saccharomyces cerevisiae, Tcpl extracellular matrix invasion by, nerve Metal ions protein role in, 5, 1065-1080 growth factor in, 4, 1205-1216 in actin reorganization, 2, 1067-1079 dynamics of, computer simulation of, 4, c-kit proto-oncogene role in, 3, 197-209 Metalloproteinases 1035-1050 Melanoma cells in NBT-II cells, transforming growth dynamin interaction with, 3, 1181-1194 adhesion to vascular endothelium, 2, factor-induced, 1, 1003-1014 of erythrocyte marginal bands, dynamics 347-355 Metastasis of, 4, 323-335

Vol. 5, December 1994 1387 Subject Index

formation of, in hepatocytes, extracellular proteins of, interactions with stress of phosphatidates, acyl chain length and, matrix control of, 5, 1277-1280 proteins, 2, 165-179 2, 57-64 in mitotic spindle formation, 3, 1259- of Saccharomyces cerevisiae, actin function regulation of, G protein oncogenes in, 3, 1267 in, 4, 1277-1294 123-128 of mouse brain neurons, tubulin transforming growth factor-,fl in, in of thrombin, mechanism of, 3, 95-102 polyglutamylation in, 4, 615-626 murine heart and liver, 2, 467-477 of v-Src protein, 5, 1177-1184 in neurite outgrowth and stabilization, 5, of yeasts Mitosis 863-875 actin-binding activity in, 5, 807-818 of amphibian eggs, calcium ion in, 1, perturbation of, viral glycoprotein function of, Ymel protein in, 5, 899- 315-326 transport and, 1, 921-936 905 blockage of, cdc25 protein of stationary plant cells, 5, 1281-1288 Mitogen(s) phosphorylation site elimination in, tubulin isotypes in, functional vs. antiproliferative growth factors, 1, 4, 1337-1350 significance of, 4, 445-457 741-746 calcium ion regulation in, 2, 915-925 yeast effects on cellular calcium responses, 1, cdc2 kinase inhibition in, by INH protein minichromosome binding to, 4, 859- 75-86, 1, 99-112 phosphatase type 2A, 5, 323-338 870 endothelin-1 as, 1, 379-390 in Drosophila melanogaster embryogenesis, proteins associated with, 3, 29-47 fibroblast response to, 2, 229-239 three rows gene in, 4, 1161-1174, Microtubule flux pertussis toxin-sensitive guanosine espl gene in, 3, 1443-1454 in mitosis, independence of, 5, 217-226 triphosphate-binding protein effects metaphase of, microtubule-associated Microtubule-affinity chromatography on, 1, 747-761 proteins in, 2, 861-874 columns thrombin as, 1, 453-463 microtubule dynamics in, 4, 1035-1050 in Drosophila protein purification, 3, 1-11 Mitogen-activated protein kinase(s) microtubule flux in, independence of, 5, Microtubule-associated protein(s) activation of, 3, 63-71 217-226 in plants, regulation of, 5, 1281-1288 by growth factors, 3, 545-553 nucleologenesis in, U3 snRNA-containing spindle, 2, 861-874 molecular signal integration in, 3, 583- bodies in, 5, 955-966 in tubulin assembly, 3, 1141-1154 592 onset of, okadaic acid effects on, 2, 391- Microtubule-associated protein 1B mos oncogenic protein kinase in, 4, 402 in neurite outgrowth and stabilization, 5, 781-790 protein phosphatase 1 in, 3, 687-698 863-875 in NIH-3T3 cells, 4, 483-493 regulation of, protein kinase dskl in, 4, Microtubule-associated protein-2 avian, immunologic characterization of, 3, 247-260 in microtubule bundling, 5, 511-517 775-787 of Schizosaccharomyces pombe phosphorylation of, by extracellular in c-jun DNA binding inhibition, 3, inhibition of, 4, 531-539 signal-regulated kinases, 2, 357-371 1117-1130 ppel+ gene in, 4, 303-313 Microtubule-associated protein kinase in epidermal growth factor-induced protein phosphatase effects on, 4, 337- activation of, 2, 965-978 processes, 4, 837-848 345 in phosphorylation, of epidermal growth FUS3 homologue of, in signal secretory pathway traffic during, 1, 415- factor-treated fibroblasts, 2, 663-673 transduction mediation, 4, 107-120 424 Microvascular endothelial cells homology to yeast protein kinases, 4, serum response elements/factors in, 2, integrin expression in, basic fibroblast 107-120 575-588 growth factor modulation of, 4, 973- inhibition of, 5, 1243-1251 Mitotic spindle apparatus 982 phosphorylation of formation and maintenance of, 3, 1259- Midbodies in Listeria monocytogenes invasion, 5, 1267 spindle proteins in, 2, 861-874 455-464 MK-801 Milk proteins, synthesis of MEK-1 protein kinase in, 5, 193-201 biologically active binding sites for, on promotion of, 3, 699-709 repression of, melanocyte growth and, lung cancer cells, 3, 613-619 regulatory mechanism for, 1, 45-54 5, 497-509 MNNG HOS osteosarcoma cells Minichromosomes regulation of, 3, 583-592 vascular permeability factor expression propagation of, mcml-l gene in, 3, 971- stimulation of, c-kit proto-oncogene in, 3, in, 3, 211-220 980 197-209 Mollusks of Saccharomyces cerevisiae, centromere in tubulin assembly, 3, 1141-1154 egg-specific NADase of, characterization function on, 4, 859-870 of, 2, 193-202, 2, 203-209, 2, 211- of Schizosaccharomyces pombe, loss of, 5, tyrosine phosphorylation of, growth 218 1145-1158 factor effects on, 2, 675-684 MOLT-4 cells Mink lung epithelial cells Mitogen-activated protein kinase homologs activator of DNA replication induction in, transforming growth factor inhibition of in yeast mating, 5, 297-312 1, 1015-1025 p34Cdc2 in, 3, 655-665 Mitogen-activated protein kinase kinase Monensin mis genes activation of, in NIH-3T3 cells, 4, 483- effects on epidermal growth factor in Schizosaccharomyces pombe, 493 receptor, 1, 174-188 abnormalities in, 5, 1145-1158 Mitogenic activity glycosaminoglycan transport and, 1, 415- Mitochondria of acidic fibroblast growth factor, 1, 975- 424 DNA of, sorting patterns of, in yeast, 4, 988 in growth factor ligand-receptor binding, 21-36 of basic fibroblast growth factor, protein 2, 599-612 intrasynaptic, cytosolic free calcium kinase C-activated, 2, 719-726 in prion protein synthesis study, 3, 851- regulation by, 3, 235-248 diacylglycerol formation in, thrombin 863 PBP74 heat shock protein in, 5, 1265- effects on, 2, 311-316 proteolysis rate and, 1, 907-919 1275 of endothlin-1, 2, 897-903 Monoclonal antibodies protein import into extracelllar signal-regulated kinase to dynein IC1 peptide, in axoneme ATP requirements for, 5, 465-474 activation by, 2, 965-978 motility inhibition, 5, 1051-1063 essential inner membrane protein for, of mast cell growth factor, c-kit proto- in phosphorylation site localization, in 5, 529-538 oncogene and, 3, 197-209 hippocampal neurons, 4, 159-172

1388 Molecular Biology of the Cell Subject Index

Monovalent antigen globin gene expression in, promoters of glp-1 gene, in Caenorhabditis elegans, 3, in crosslinking of IgE receptor with for, 4, 1077-1085 1199-1213 membrane skeleton, 2, 181-191 transthyretin gene of, RNA polymerase of keratinocytes, cell cycle protein levels Morphologic transformation mapping on, 3, 1085-1094 in, 4, 185-194 v-Src protein in, 5, 1177-1184 tumor necrosis factor regulation in, in of macrophage colony-stimulating factor Morris hepatoma cells lipopolysaccharide stimulation, 3, receptor gene, 5, 81-95 connexin43 gene transcription regulation 451-460, Wnt-1 proto-oncogene of, of mouse mammary cells, Wnt-1 proto- in, 3, 839-850 characterization of, 3, 532-533 oncogene in, 3, 532-533 Mos oncogenic protein kinase MP70 lens fiber protein of mtr2 gene, nucleolar fragmentation in, in mitogen-activated protein kinase mouse gap junction Cx5O protein 5, 1253-1263 activation, 4, 781-790 identified as, 3, 711-720 of N-linked oligosaccharide synthesis and Motility MPM-2 antigens processing genes, 5, 253-265 of Dictyostelium, myoA gene in, 4, 233- in maturation-promoting factor of protein kinase cdc2, in Xenopus oocyte 246 activation, 5, 135-145 maturation, 5, 587-596 Mouse MRC-5 cells of rad genes, in Schizosaccharomyces brain neurons of, tubulin small nuclear ribonucleoprotein particle pombe, 5, 147-160 polyglutamylation in, 4, 615-626 localization in, 3, 555-569 of Saccharomyces cerevisiae, nuclear BW1J cell line of, in liver gene regulation mRNA. See Messenger RNA protein localization defects in, 3, study, fetal vs. adult, 4, 59-69 MT-2 cells 875-893 c-kit ligand expression in, 3, 349-362 interleukin-2 receptor phosphorylation of Schizosaccharomyces pombe genes, extracellular signal-regulated kinases in, and, 2, 73-85 morphogenesis and, 5, 613-616 2, 357-371 mtr2 gene of sec71-1 and sec72-1 genes, in fibroblasts of mutation of, nucleolar fragmentation in, Saccharomyces cerevisiae, 5, 933-942 muscle-specific actin gene promoter 5, 1253-1263 of tcp genes, in Saccharomyces cerevisiae, activation in, 3, 1073-1083 Multi-colony-stimulating factor 5, 1065-1080 nuclear factor kappa B-like activity in receptor expression transregulation, in of TORI and TOR2 genes, in induced in, 3, 1131-1139 myeloid cells, 3, 535-544 Saccharomyce cerevisiae, 5, 105-118 gap junction Cx5O protein of, mup-1 gene of f,-tubulin gene, in yeasts, 5, 29-43 identification as lens fiber protein mutation of, dpy gene suppression of, 4, of v-src genes, Saccharomyces cerevisiae MP70, 3, 711-720 803-817 growth inhibition in, 5, 283-296 LB6 cells of, urokinase-type plasminogen Murine epidermal growth factor of yeast CDC genes, signal transduction activator in, 2, 793-803 ligand-binding specificity of, 2, 337-345 path and, 1, 391-401 mammary epithelial cells of Muscarine of YNT1 gene, yeast mitochondrial cyclic AMP production and, 2, 13-25 function and, 5, 899-905 ,B-casein gene expression in, regulation MvlLu cells of, 3, 699-709 Muscarinic acetylcholine receptors transforming growth factor inhibition epidermal growth factor receptor activation of, small cell lung carcinoma of down-regulation in, 4, 773-780 inhibition by, 2, 373-381 p34Cdc2 in, 3, 655-665 Ha-ras transformed, syndecan-1 myc gene Muscle in cellular growth arrest bypass, 5, 375- translational expression in, 4, 849- calmodulin gene expression regulation in, 858 2, 819-826 388 neoplastic transformation of, by excitation-contraction coupling in, myc protooncogene deregulated myc expression, 1, 863- transverse tubule/sarcoplasmic in epithelial cell neoplastic 872 reticulum junction organization in, 5, transformation, 1, 863-872 steroid-induced syndecan suppression 1105-1118 Myelin basic protein in, 2, 1-11 smooth, connexin expression in, 4, 7-20 in fibroblast growth factor methylation mammary tumor virus of striated, merosin in, 1, 731-740 studies, 2, 87-93 envelope protein of, maturation of, tenascin variants in, 2, 927-938 phosphorylation of, by extracellular glucocorticoids in, 1, 531-541 Muscular dystrophy signal-regulated kinases, 2, 357-371 promoter for, in casein synthesis study, Duchenne, dystrophin studies in, 5, Myelin basic protein kinases 3, 699-709 1159-1167 activation of, 2, 965-978, 3, 1329-1337 mitochondria of, transforming growth dystrophin expression in, 4, 963-972 Myelo-monocytic cells factor-fll in, 2, 467-477 Mutagenesis proliferation of, immunophilin ligands platelet-derived growth factor receptors in integrin functional determinant effects on, 3, 981-987 of, 3, 545-553 mapping, 1, 597-604 Myoblasts proximal tubular epithelial cells of, Mutation differentiation of, ElA protein angiotensin II-treated, collagen of actin gene, of yeast, 4, 459-468 suppression of, 3, 1107-1115 secretion from, 2, 219-227 of Dictyostelium G proteins, enzyme skeletal, adhesive interactions with T cells of, interleukin-2 receptor activation and, 3, 735-747 thrombospondin-1, 5, 423-437 phosphorylation and, 2, 73-85 of epidermal growth factor receptor gene, Myocardial infarction 3T3 fibroblasts of, Gi protein in, a responsiveness enhancement by, 5, experimental, transforming growth subunit(s) of, subcellular distribution 739-746 factor-fl1 mRNA in, 2, 241-249 of, 2, 1097-1113 of epidermal growth factor-receptor, 1, Myocardium T lymphoma cells of, virus envelope 173-188 connexin43 in, 4, 7-20 protein maturation in, of FUS3 genes, promoting Myocytes glucocorticoids in, 1, 531-541 autophosphorylation, in yeast cardiac, vascular permeability factor transgenic mating, 5, 297-312 expression in, 3, 211-220 full-length dystrophin expression in, of G protein subunit genes, of growth factor for, 2, 1081-1095 normal calcium regulation in, 5, Dictyostelium, 5, 691-702 murine, transforming growth factor-fll 1159-1167 of G proteins, 3, 123-128 in, 2, 467-477

Vol. 5, December 1994 1389 Subject Index

protein kinase C translocation in, 1, 693- Neoplastic cells. See also Carcinoma cells factors affecting, 5, 863-875 706 glia maturation factor d effects on, 1, protein kinase C effects on, 3, 323-333 Myofibrils 741-746 in retinoic acid-treated neuroblastoma protein kinase C translocation to, 1, 693- transformation to, myc protooncogene in, cells, response to laminin, 2, 1021- 706 1, 863-872 1033 Myogenic determination protein MyoD Neovascularization Neurite extension assay in cell cycle arrest, 4, 705-713 heparanase in, 1, 833-842 in heparin-binding growth-associated Myo-inositol Nerve(s) molecule characterization, 3, 85-93 brain calcium uptake and, 1, 781-790 merosin in, 1, 731-740 Neuro 2A cells Myosin Nerve cells guanine nucleotide-binding regulatory in fibroblasts, concentration and assembly nerve growth factor activity in, 3, 363- protein distribution in, 3, 49-61 of, 4, 819-836 371 Neuroblastoma cells filaments of, assembly of, in nonmuscle Nerve growth factor phospholipase D regulation in, 2, 1011- cells, 4, 1051-1067 activity of, in pheochromocytoma cells, 3, 1019 function of, review of, 1, 1-11 363-371 Myosin I retinoic acid differentiation of, integrin binding to trkA receptor, 5, 549-563 expression and, 2, 1021-1033 in cell movement, 1, 55-63 in epidermal growth factor receptor Myosin II desensitization, 4, 737-746 Neuroendocrine cells, Wnt gene family in, of Dictyostelium, lacking 58kD tail in extracellular signal-related kinase 4, 1267-1275 portion, 3, 1455-1462 phosphorylation, 3, 299-308 Neurofilament(s) phosphorylation of, dynamics of, 3, in gene activation in FOS-expressing in neurite outgrowth and stabilization, 5, 1037-1048 cells, 1, 347-357 863-875 Myotubes mechanisms of action of, 2, 685-690, 2, phosphorylation of, by catalytic subunit dystrophin expression in, 4, 963-972 691-697 of cAMP-dependent protein kinase, Myristoylated and alanine-rich C-kinase in melanoma extracellular matrix 5, 161-172 substrate (MARCKS) antibody invasion, 4, 1205-1216 Neurofilament L protein phosphorylation in bradykinin response studies, 2, 229- in neurite outgrowth, 3, 323-333 structural effects of, 1, 237-248 239 neurite response to, in retinoic acid- Neurokinin receptors Myristoyl-coenzyme A treated neuroblastoma cells, 2, 1021- physiological actions of, 2, 767-779 in asialoglycoprotein receptor activity 1033 Neuron(s) regulation, in hepatocytes, 5, 227- in neuronal differentiation, 3, 545-553 cAMP signaling in, AKAP 150 protein in, 235 in PC12 cell differentiation, inhibition of, 3, 1215-1228 4, 353-361 cyclic AMP production in, agonist effects pheochromocytoma cell differentiation on, 2, 13-25 by, adenovirus early response gene cytoskeleton of, calcineurin in, 4, 1225- NADase product inhibition of, 2, 479-489 1238 egg-specific, molluscan, characterization in phospholipid metabolism, 2, 383-390 differentiation of, platelet-derived growth of, 2, 193-202, 2, 203-209, 2, 211- in protein kinase expression, in PC12 factor receptors in, 3, 545-553 218 cells, 5, 1225-1241 dorsal root ganglion, calcium releasing NADPH oxidase receptor for agents effects on, 3, 1415-1425 of neutrophils, activation of, Rac proteins antibodies to, 2, 691-697 growth factor effects on, 1, 189-195, 1, in, 4, 261-269 lateral diffusion of, 1, 605-614 511-521 regulation of, Rac GTPase activating protein kinase activity of, purine- hippocampal, protein kinases of, proteins in, 4, 1217-1223 analogue-sensitive, 4, 71-78 autophosphorylation of, 4, 159-172 National Institutes of Health tyrosine kinase as, 2, 685-690 mouse brain, tubulin polyglutamylation basic science and, 5, 267-272 receptor-activating site of, 1, 189-195 in, 4, 615-626 NBT cells Nerve terminals Neuronal expression acidic fibroblast growth factor effects on, presynaptic, calcium concentration of Drosophila G protein subunits, 1, 125- 1, 975-988 regulation in, mitochondrial in, 3, 134 transforming growth factor effects on, 1, 235-248 Neurotensin 1003-1014 Nervous tissue in calcium ion-stimulated chloride N-cadherin cadherins in, 2, 261-270 conductance in epithelial cells, 1, mutant, cell-cell adhesion disruption neu receptor tyrosine kinase activation with, 4, 37-47 951-963 in platelet-derived growth factor receptor Neurotrophin receptors NCI-H187 cells down-regulation, 2, 651-661 binding sites on, for non-opioid autophosphorylation of, inhibition of, 3, substances, 3, 613-619 Neural cell adhesion molecule 677-686 nda gene heparin interaction with, 1, 567-576 in melanoma invasion, 4, 1205-1216 of Schizosaccharomyces pombe, functions Neural cells Neutrophils of, 4, 1003-1015 collagen binding to, NG2 proteoglycan actin polymerization in, 3, 1427-1435 Nematode(s) and, 4, 1097-1108 CR1 internalization in, 2, 41-55 G proteins in, characterization of, 2, 135- Neuraminidase heparanase activity expression by, 1, 154 in cell adhesion efficiency testing, 3, 157- 833-842 Nematode actin capping protein 166 NADPH oxidase activation in, Rac expression in yeast, 4, 907-917 Neurite(s) proteins in, 4, 261-269 neo gene formation of, growth factor induction of, NF1 expression of, in Trypanosoma brucei, 3, 1, 511-521 in ras GTPase activation, 3, 1437-1442 749-759 growth of, in PC12 cells, nerve growth NF-*kappaB protein Neoplasia factor effects on, 4, 353-361 regulation of, signal transduction G protein oncogenes in, 3, 123-128 outgrowth of pathway for, 4, 767-771

1390 Molecular Biology of the Cell Subject Index

NG108-15 neuroblastoma cells NPL3 gene NUP2 gene phospholipase D regulation in, 2, 1011- characterization of, 3, 875-893 isolation of, 4, 209-222 1019 NR 6 cells NG2 proteoglycan mitogen effects on, 1, 747-761 in collagen retention on cell surface, 4, nrd gene 1097-1108 expression of, cell cycle regulation of, 3, Nickel ion 1095-1105 Octanol in actin reorganization, 2, 1067-1079 NRK-49F cells in intracellular calcium release, 2, 513- bacterial chemotactic response to, thrombospondin-transforming growth 522 computer simulation of, 4, 469-482 factor complexes in, 3, 181-188 Okadaic acid in calcium influx to T lymphocytes, 4, Nuclear envelope in collagenase gene expression, 1, 269- 173-184 of endoplasmic reticulum, 3, 1067-1072 278 Nicotine Nuclear factor kappa B effects on mitosis onset, 2, 391-402 cyclic AMP production and, 2, 13-25 activation of, 2, 329-335 in gap junction communication, 3, 865- Nifedipine nuclear localization signal of, masking of, 874 brain calcium uptake and, 1, 781-790 3, 1339-1352 myosin II phosphorylation and, 3, 1037- NIH 3T3 cells Nuclear factor kappa B-like activity 1048 epidermal growth factor-receptor domain induced by platelet-derived growth 1-Oleoyl-2-acetoyl glycerol deletion and, 1, 173-188, 1, 173-188 factor, 3, 1131-1139 mitogenic activity of, 2, 57-64 fibroblast growth factor effects on, Nuclear localization domains 1-Oleyl phosphatidate heparanase activity and, 1, 833-842 of steroid hormone receptors, 1, 291-299 mitogenic activity of, 2, 57-64 Nuclear pore complex Oligomerization fibronectin/integrin interactions in, proteins of, functions of, 4, 209-222 in epidermal growth factor-receptor protein (120-kDa) phosphorylation Nuclear proteins activity, 1, 173-188 in, 2, 951-964 in gene modulation, in G1 period, 2, 575- Oligosaccharides high molecular weight basic fibroblast 588 N-linked, in endoplasmic reticulum growth factor expression in, 2, 699- localization of, in Saccharomyces cerevisiae glycoprotein folding, 5, 253-265 708 mutant, 3, 875-893 Oncogenes mitogen effects on, 1, 75-86, 1, 747-761 Nuclear receptors effects on oocytes, 1, 543-554 mitogen-activated protein kinase keratin gene transcription and, 1, 965- of G proteins, in mitogenesis regulation, pathway in, activation of, 4, 483-493 973 3, 123-128 neurotrophin receptor Nuclear-mitotic apparatus protein autophosphorylation inhibition in, 3, in bipolar mitotic spindle apparatus, 3, Oncogenic viruses 677-686 1259-1267 protein phosphatases alterations by, 2, phosphoinositide hydrolysis in, epidermal Nucleation 589-598 growth factor-induced, 1, 615-620, in actin polymerization, 3, 1309-1315 Oncogenicity. See also Tumorigenicity 1, 615-620 Nucleic acids of basic fibroblast growth factor, 2, 709- transfected with serotoninlA receptors, 3, binding of, Xenopus nucleolin in, 4, 1189- 718 961-969 1204 Oocytes. See also Egg(s) transformation of Nucleolin calcium oscillations in, inositol Wnt-1 proto-oncogene in, 3, 532-533 nucleolar targeting of, 4, 1239-1250 trisphosphate analogues in, 1, 675- vinculin gene expression in, 1, 621-636 of Xenopus, in nucleic acid binding, 4, 681 Nitric oxide 1189-1204 cell-free translation system preparation in guanylyl cyclase activation, 5, 4 Nucleolus from, 1, 1057-1067 N-[7-(4-Nitrobenzo-2-oxa-1,3-diazole)]-6- formation of, U3 snRNA-containing gap junction protein communication ion, aminocaproyl D-erythro-sphingosine bodies in, 5, 955-966 1, 989-1002, ras oncogene effects on, dispersion during mitosis, 1, 415-424 nucleolin localization in, 4, 1239-1250 1, 543-554 NK receptors of Saccharomyces cerevisiae, fragmentation starfish physiological actions of, 2, 767-779 of, in mRNA accumulation, 5, 1253- maturation of, effectors for, 4, 1027- NMuMG cell line 1263 1034 epidermal growth factor receptor down- of Xenopus, nucleolin localization in, 4, meiosis of, regulation of, 4, 1295-1306, regulation in, 4, 773-780 1189-1204 Xenopus Nocodazole Nucleoporins cdc25 protein phosphorylation site in calcineurin localization, 4, 1225-1238 functions of, 4, 209-222 elimination in, 4, 1337-1350 as glutamylation inhibitor, in mouse Nucleotide(s) glucose uptake in, vanadate effects on, brain neurons, 4, 615-626 membrane binding protein for, in protein 2, 317-327 in viral glycoprotein transport, 1, 921- transfer across endoplasmic human p80-coilin insertion into, 5, 936 reticulum membrane, 2, 851-859 1119-1127 NOG-8 ras cells Nucleotide exchange maturation of, mutant cdc2 protein syndecan-1 translational expression in, 4, in actin polymerization, 3, 1015-1024 kinase in, 5, 587-596 849-858 Nucleus mitogen-activated protein kinase Nonmyocyte-derived growth factor cAMP-dependent protein kinase free activation in, 4, 781-790 (NMDGF), 2, 1081-1095 catalytic subunit translocation in, 4, Oogenesis Nordihydroguaiaretic acid 993-1002 in Xenopus, p40mol' in, 5, 921-932 in crosslinking of IgE receptor with nucleolin localization in, 4, 1239-1250 Opioids membrane skeleton, 2, 181-191 of Schizosaccharomyces pombe, cyclin B binding sites for, on lung cancer cells, 3, in HeLa spreading on substrates, 3, 481- distribution in, 4, 1087-1096 613-619 492 of yeast, mRNA accumulation in, o-rab3 protein Norepinephrine nucleolar fragmentation in, 5, 1253- in secretory granule localization, in AtT- cyclic AMP production and, 2, 13-25 1263 20 cells, 4, 747-756

Vol. 5, December 1994 1391 Subject Index

ORF YGLO22 protein p80 protein nerve growth factor receptors of, protein yeast, vs. Schizosaccharomyces pombe phosphorylation of, in response to kinase inhibition in, 4, 71-78 stsl+ gene product, 3, 263-273 phorbol esters in cells overexpressing neurotrophin receptor Organelles protein kinase C, 3, 1049-1056 autophosphorylation inhibition in, 3, sphere, of amphibian germinal vesicles, p90 protein 677-686 human p80-coilin targeted to, 5, phosphorylation of, in response to protein kinase antibody introduction to, 1119-1127 phorbol esters in cells overexpressing neurite outgrowth and, 3, 323-333 Ornithine decarboxylase protein kinase C, 3, 1049-1056 protein kinase expression in, nerve interferon effects on, 1, 215-226 p105 yeast protein growth factor regulation of, 5, 1225- OS-ACS genes in endoplasmic reticulum vesicle 1241 expression of, in deepwater rice plants, 4, budding, 3, 667-676 tyrosine kinase receptors in, epidermal 363-373 growth factor receptor Oscillations desensitization in, 4, 737-746 in calcium concentration, in smooth peb genes muscle cells responding to of Saccharomyces cerevisiae, 4, 1351-1359 extracellular ATP, 3, 493-505 PADGEM (P-selectin, CD62, GMP-140) Pentosan polysulfate of cytosolic calcium ion, 1, 853-861 cytoplasmic domain of, in sorting into in calcium release channel activation, 4, Osmoregulation, Schizosaccharomyces pombe regulated pathway of secretion, 3, 347-352 stsl+ gene in, 3, 263-273 309-321 Pepstatin Osteoblasts Palmitoyl-coenzyme A as protease inhibitor, in T-cell receptor alkaline phosphatase release by, in asialoglycoprotein receptor activity chain degradation studies, 2, 753- inhibition of, 2, 889-896 regulation, in hepatocytes, 5, 227- 765 Osteonectin, Caenorhabditis elegans 235 Peptide(s) homologue of, functions of, 4, 941- Pancreatic acinar cells arg-gly-asp-containing, in fibroblast 952 coat protein accumulation in, in collagen receptor location, 2, 1035- Osteopontin endoplasmic reticulum-Golgi 1044 adhesive properties of, regulation of, 5, transport disruption, 4, 413-424 immunogenic, production during antigen 565-574 Pancreatic islet cells processing, 1, 502-506 expression and distribution of, 3, 1169- insulin secretion in, actin filament role in, nerve growth factor inhibition by, 1, 189- 1180 5, 1199-1213 195 Osteosarcoma cells Papovaviruses non-proline-containing, cyclophilin cross- adhesion to vascular endothelium, 2, protein phosphatases alterations by, 2, linking to, 4, 223-232 347-355 589-598 from sperm bindin protein, in species- vascular permeability factor expression Parathyroid hormone specific fertilization inhibition, 4, in, 3, 211-220 alkaline phosphatase inhibition by, in 375-387 Oxalate mutant osteoblasts, 2, 889-896 Peptide mapping brain calcium uptake and, 1, 781-790 release of, extracellular calcium ion in, 5, in extracellular signal-regulated kinases Oxyrrhis marina 725-737 phosphorylation, 3, 299-308 motility of, dynein IC1 peptide in, 5, Parietal cells Peptide-mating factor 1051-1063 chloride/bicarbonate exchange in, yeast cell exposure to, FAR1 p33""2 protein regulation of, 2, 727-73 phosphorylation and, 3, 445-450 expression of, in PC12 cells, nerve gastric acid secretion from, calcium role Peptidyl epoxide E64 growth factor regulation of, 5, 1225- in, 2, 27-39 as protease inhibitor, in T-cell receptor 1241 sodium flux in, 1, 259-268 chain degradation studies, 2, 753- p34c protein Parthogenesis 765 regulation of second messengers in, 1, 279-290 Peptite-2000 cdc25+ protein in, 3, 73-84 Parvalbumin in fibronectin/integrin interactions in cell cycle, 5, 989-1001 dissociation constant of, 1, 165 studies, 2, 951-964 in Xenopus cyclin B2 degradation, 5, 713- structure of, 1, 166 Period of oscillations 724 PBP74 heat shock protein of calcium vs. p34' protein characterization of, 5, 1265-1275 cytosolic ion, latency, 1, expression of, in PC12 cells, nerve PC12 cells. See also Pheochromocytoma 853-861 growth factor regulation of, 5, 1225- cells Peripheral nerves 1241 clathrin light chain alteration in, 4, 647- merosin in, 1, 731-740 p4OM015 660 Peroxisomal membrane protein in Xenopus oogenesis and embryogenesis, differentiation of cyclophilin cross-linking to, 4, 223-232 5, 921-932 induced by nerve growth factor, Peroxisome(s) p42 mitogen-activated protein kinase inhibition of, 4, 353-361 of Hansenula polymorpha, alcohol oxidase tyrosine phosphorylation of, growth platelet-derived growth factor receptors assembly in, flavin adenine factor effects on, 2, 675-684 in, 3, 545-553 dinucleotide requirements in, 5, 829- p42 protein kinase early growth response gene regulation in, 837 activation of, 3, 1329-1337 1, 347-357 Peroxisome biogenesis p52 protein gene expression in in yeasts, 4, 1351-1359 phosphorylation of, in response to pituitary adenylate cyclase activating Pertussis toxin phorbol esters in cells overexpressing polypeptide in, 3, 941-951 CR1 internalization and, 2, 41-55 protein kinase C, 3, 1049-1056 growth factor effects on, 1, 511-521 in DNA synthesis, 3, 961-969 p63 protein kinase nerve growth factor binding sites on, 5, in embryonic heart development, 1, 301- activation of, 3, 1329-1337 549-563 313 p87 protein kinase nerve growth factor receptor diffusion in, as mitogen-activated protein kinase activation of, 3, 1329-1337 1, 605-614 inhibitor, 2, 675-684

1392 Molecular Biology of the Cell Subject Index

in phosphoinositide hydrolysis, 1, 615- Pheromones hydrolysis of, receptor-dependent, 2, 620 of Saccharomyces cerevisiae 299-303 PET111 protein in mating projection formation, 3, 429- metabolism of, endothelin-1 effects on, 2, in Saccharomyces cerevisiae COX2 gene 444, 3, 1025-1035 897-903 alteration, 4, 1327-1335 receptors for, 2, 439-452, 4, 511-521 mitogenic activity of, 2, 57-64 pH in signal transduction, 4, 107-120, 4, profilin affinity for, 1, 937-950 intracellular, in gastric parietal cells, 2, 495-510 Phosphatidylethanolamine 727-737 in yeast signal transduction, 1, 391-401 mitogenic activity of, 2, 57-64 role of, in HeLa cell spreading on Phorbol esters Phosphatidylinositol substrates, 3, 481-492 in interferon-induced gene expression profilin affinity for, 1, 937-950 Phalloidin-binding site inhibition, 1, 707-713 Phosphatidylinositol kinase on actin, of Saccharomyces cerevisiae, 4, in protein kinase C overexpression, 3, platelet-derived growth factor receptor 1277-1294 1049-1056 binding to, 4, 49-57 1,10-Phenanthroline Phorbol 12-myristate 13-acetate of TOR1 and TOR2 protein homology as protease inhibitor, in T-cell receptor in actin reorganization modulation, 2, with, 5, 105-118 chain degradation studies, 2, 753- 1067-1079 Phosphatidylinositol phosphates 765 in amphibian egg activation, 1, 315-326 profilin affinity for, 1, 937-950 Phencycidine in angiotensin II-induced tubular Phosphatidylinositol serine biologically active binding sites for, on epithelial hypertrophy, 2, 219-227 profilin affinity for, 1, 937-950 lung cancer cells, 3, 613-619 c-kit ligand expression effects of, 3, 349- 362 Phosphoinositide(s) Phenothiazines in crosslinking of IgE receptor with brain calcium uptake and, 1, 781-790 in calcium influx to T lymphocytes, 4, membrane skeleton, 2, 181-191 hydrolysis of, epidermal growth factor- 173-184 in embryonic heart development, 1, 301- induced, 1, 615-620 Phenylarsinoxide 313 stimulation of, in sea urchin eggs, in growth factor ligand-receptor binding, in interleukin-4 gene expression, 1, 425- guanosine 5'-thiotriphosphate in, 2, 2, 599-612 434 121-133 Phenylbutyryl-leu-norleu-chloromethyl leukocyte integrin activity on Phosphoinositide pathway ketone nonhematopoietic cells and, 1, 359- in sea urchin egg activation, 3, 373-383 as protease inhibitor, in T-cell receptor 367 Phosphokinase chain degradation studies, 2, 753- neurite response to, in retinoic acid- in hippocampal neurons, localization of, 765 4, 159-172 treated neuroblastoma cells, 2, 1021- Phospholipase(s), in phosphatidylcholine Phenylephrine 1033 hydrolysis, receptor-dependent, 2, in calcium signal coordination, 3, 113- neurographic activity of, 1, 189-195 299-303 121 nuclear factor kappa B activation and, 2, Phospholipase A2 cyclic AMP production and, 2, 13-25 329-335 in HeLa cell spreading on substrates, 3, Phenylmethylsulfonyl fluoride in platelet granule secretion, 1, 1027- 481-492 as protease inhibitor, in T-cell receptor 1041 inhibition of, cell spreading and, 4, 271- chain degradation studies, 2, 753- as protein kinase inhibitor, in tumor cell 281 765 adhesion, 2, 1045-1055 Phospholipase C Phenylthiohydantoin derivatives in talin phosphorylation, 1, 227-236 activation of in fibroblast growth factor methylation T-cell stimulation with, phospholipase D inhibition of, 3, 735-747 studies, 2, 87-93 activity in, 2, 841-850 by thrombin receptor peptides, 3, 95- Pheochromocytoma cells. See also PC12 in vascular smooth muscle cell 102 cells preparation, heparin effects on, 1, activity of, neurokinin receptors in, 2, differentiation of, platelet-derived growth 435-443 767-779 factor receptors in, 3, 545-553 Phorbol-12,13-dibutyrate in DNA synthesis, a-adrenergic agonists early growth response gene regulation in, in angiotensin II-induced tubular effects on, 1, 445-451 1, 347-357 epithelial hypertrophy, 2, 219-227 epidermal growth factor effects on, 1, gene expression in, pituitary adenylate in interferon-induced gene expression 615-620 cyclase activating polypeptide in, 3, inhibition, 1, 707-713 inhibition of, profilins in, 1, 937-950 941-951 Phosphatases phosphorylation of, 3, 583-592 growth factor effects on, 1, 511-521 alterations of, oncogenic viruses in, 2, in platelet granule secretion, 1, 1027- nerve growth factor activity in, 3, 363- 589-598 1041 371 inhibitors of, in collagenase gene Phospholipase C*gamma nerve growth factor receptor diffusion in, expression, 1, 269-278 tyrosine phosphorylation of, 2, 641-649 1, 605-614 in protein kinase regulation, 3, 299-308 Phospholipase C*gammal nerve growth factor receptors in, of Schizosaccharomyces pombe binding to platelet-derived growth factor phosphoprotein association with, 2, cell morphogenesis and, 4, 303-313 receptor, 4, 49-57 691-697 mitosis and, 4, 337-345 phosphorylation of, ultraviolet radiation nerve growth factor-induced Phosphate buffer induction of, 4, 523-530 differentiation of, adenovirus early effects on microtubule dynamics, 4, 323- tyrosine phosphorylation of, 2, 413-425 gene inhibition of, 2, 479-489 335 Phospholipase D neurotrophin receptor Phosphatidates activation of autophosphorylation inhibition in, 3, mitogenic properties of, 2, 57-64 endothelin-1 in, 2, 897-903 677-686 Phosphatidic acid T-cell antigen receptor/CD3 complex phospholipid metabolism in, carbachol production of, in phosphatidylcholine in, 2, 841-850 effects on, 2, 383-390 hydrolysis, 2, 299-309 guanine nucleotide-activated, calcium protein kinase C effects on, 3, 323-333 Phosphatidylcholine inhibition of, 2, 1011-1019

Vol. 5, December 1994 1393 Subject Index

Phospholipid(s) receptor, phospholipase C*gammal urokinase-type. See Urokinase-type metabolism of, carbachol effects on, 2, binding and, 4, 49-57 plasminogen activator 383-390 on platelet-derived growth factor receptor Plasminogen activator inhibitor, 1, 1043- mitogenic properties of, 2, 57-64 subunits, 2, 413-425 1056 Phospholipid-binding proteins of ppl25 protein, platelet integrin in, 3, expression of, in teratocarcinoma cells, 2, calcium-dependent, 1, 168 989-998 285-297 Phosphomannosyl receptors of protein kinases type 1, production of, in endothelial cells, cholesteryl ester metabolism and, 1, 661- vs. cell cycle stage, 4, 247-260 cytokine effects on, 4, 135-144 674 in hippocampal neurons, 4, 159-172 Platelet(s) Phosphoproteins of Saccharomyces cerevisiae, cell cycle actin polymerization in, 3, 1427-1435 in pheochromocytoma cells, nerve and, 4, 195-208 adhesion/activation of, integrin a2fll- growth factor receptor association of talin, 1, 227-236 mediated, 2, 905-913 with, 2, 691-697 of tau protein, tubulin assembly and, 3, GPIIb-IIIa, affinity modulation of, 1, 883- Phosphorylation. See also 1141-1154 893 Autophosphorylation; Tyrosine in vascular endothelial cell injury, 5, 349- granules of, factors affecting secretion phosphorylation 361 from, 1, 1027-1041 aberrant, in Saccharomyces cerevisiae of Xenopus cdc25 phosphatase, heparanase activity expression by, 1, growth inhibition, 5, 283-296 oscillations in, 3, 927-939 833-893 of adherens-type junctions in Rous in Xenopus p34CdC2 activating kinase integrins of, signal transduction by, 3, sarcoma virus-transformed cells, 2, identification, 3, 13-27 989-998 105-120 in yeast signal transduction, FUS3 profilin of, in phospholipase C inhibition, in bacterial chemotaxis, computer mediation of, 4, 107-120 1, 937-950 simulation of, 4, 469-482 Phosphorylcholine P-selectin of, in sorting into regulated of cAMP receptors, second messenger production of, in phosphatidylcholine secretion pathway, 3, 309-321 regulation of, 3, 603-612 hydrolysis, 2, 299-303 of cdc2 protein kinase, 5, 273-282 Phytohemagglutinin-P Platelet-activating factor of cellular proteins, in response to effects on cellular calcium responses in macrophages stimulated by, calcium phorbol esters in cells overexpressing human leukemic T cells, 1, 99-112 response of, 2, 513-522 protein kinase C, 3, 1049-1056 Pinocytosis metabolites of, smooth muscle activity of, in collagenase gene expression, 1, 269- in CR1 internalization, 2, 41-55 1, 13-25 278 PIPES buffer tumor necrosis factor release and, 3, 451- of connexin43, epidermal growth factor effects on microtubule dynamics, 4, 323- 460 in, 3, 865-874, 4, 837-848 335 Platelet-derived endothelial cell growth of extracellular signal-regulated kinase 2, Pirenzipine factor repression of, melanocyte growth cyclic AMP production and, 2, 13-25 in placenta, 1, 577-584 and, 5, 497-509 Pituitary adenylate cyclase activating Platelet-derived growth factor of extracellular signal-regulated kinases, polypeptide cellular calcium responses and, 1, 75-86 2, 965-978, 3, 299-308 in pheochromocytoma gene expression, 3, in cellular protein phorphorylation, 3, of FAR1 protein, in cell-cycle arrest, 3, 941-951 1049-1056 445-450 Pituitary somatotrophs in cyclin D mRNA expression regulation, of gap junction proteins, inhibition of, 1, G protein oncogenes and, 3, 123-128 4, 1133-1144 989-1002 Placenta extracellular regulation of, 3, 1057-1065, of gpl3O, in Jak2 kinase activation, in laminin/merosin in, 1, 731-740 gro gene expression stimulation by, hepatocytes, 5, 819-828 platelet-derived endothelial cell growth 2, 739-752 of integrins, factors affecting, 2, 271-283 factor in, 1, 577-584 vs. heparin-binding growth factor, 1, of interleukin-2 receptors, 2, 73-85 Placental membrane cells 811-819 of lymphocytes, ultraviolet radiation granulocyte-macrophage colony- in inositol polyphosphate formation, 5, induction of, 4, 523-530 stimulating factor receptor in, 1, 17-27 MEK-1 protein kinase in, 5, 193-201 327-335 isoforms of, secretory patterns of, 2, 503- of microtubule-associated spindle Plakoglobin 512 proteins, 2, 861-874 cadherin complexes with, 4, 37-47 in mitogen-activated protein kinase of mitogen-activated protein kinase, in Plasma cells activation, 3, 63-71, 4, 483-493 Listeria monocytogenes invasion, 5, syndecan expression on, 1, 27-35 mitogenic signaling pathways of, 1, 747- 455-464 Plasma membrane 761 molecular signal integration in, 3, 583- permeability of, in anthrax lethal toxin in myocyte growth modulation, 2, 1081- 592 action, 3, 1269-1277 1095 of MPM-2 antigens, 5, 135-145 prion protein export to, 3, 851-863 nuclear factor kappa B-like activity of myosin II, dynamics of, 3, 1037-1048 selectin expression, fate after, 4, 791-801 induced by, 3, 1131-1139 of neurofilament L protein, structural Plasmin receptor for effects of, 1, 227-236 in vascular endothelial growth factor cDNA of, 3, 761-773 of neurofilaments, by catalytic subunit of release from extracellular matrix, 4, down-regulation of, 2, 651-661 cAMP-dependent protein kinase, 5, 1267-1275 in neuronal differentiation, 3, 545-553 161-172 Plasminogen activation phospholipase C*gammal binding to, in neurons, calcineurin in, 4, 1225-1238 in leukemia cells, alpha2-macroglobulin 4, 49-57 of oocyte receptors, vanadate effects on, effects on, 2, 1057-1065 subunits of, tyrosine phosphorylation 2, 317-327 Plasminogen activator on, 2, 413-425 of platelet granule secretion, 1, 1027- on melanoma cell surface, 1, 895-905 review of, 1, 555-566 1041 receptors for, on keratinocytes, 1, 843- subunits of, tyrosine phosphorylation on, on platelet-derived growth factor 852 2, 413-425

1394 Molecular Biology of the Cell Subject Index

in urokinase-type plasminogen activator Polymorphonuclear neutrophils Prion proteins expression, 2, 285-297 actin polymerization in, 3, 1427-1435 synthesis of, 3, 851-863 in vascular smooth muscle cell growth Polyomavirus Profilins stimulation, 1, 821-831 protein phosphatases alterations by, 2, in actin nucleotide exchange, 3, 1015- in vinculin gene expression induction, 1, 589-598 1024 621-636 Polypeptides in injury response, 3, 403-414 Platelet-derived growth factor-AA transfer across endoplasmic reticulum in phospholipase C inhibition, 1, 937-950 homodimer membrane, ATP-binding protein in, Progesterone in endothelin-specific transcript 2, 851-859 glucocorticoid receptor binding of, 3, induction, 1, 649-659 translocation of, across endoplasmic 1245-1257 Pleckstrin phosphorylation reticulum membrane, in yeast, 4, in Xenopus laevis oocytes, vanadate in platelet granule secretion, 1, 1027- 931-939 effects on, 2, 317-327 1041 Polyphosphoinositides Programmed cell death Pleiotropic drug sensitivity, profilin affinity for, phospholipase C blocking of, extracellular matrix in, 4, Schizosaccharomyces pombe stsl+ inhibition and, 1, 937-950 953-961 gene in, 3, 263-273 Polyvinyl sulfate Prolactin Pleotrophin (heparin-binding growth- in calcium release channel activation, 4, in f,-casein synthesis, 3, 699-709 associated molecule) 347-352 in epidermal growth factor receptor characterization of, 3, 85-93 Porcine kidney epithelial cells down-regulation, 4, 773-780 PMR1 (calcium-ATPase homologue) protein kinase C overexpression in, Proliferating cell nuclear antigen localization of, in Golgi system, 3, 633- effects of, 2, 491-502 in cyclin/cyclin-dependent kinase 654 Pore formation complexes, 4, 897-906 Polar residues in sea urchin eggs, 1, 65-74 in DNA polymerase III holoenzyme in protein retention, in Golgi apparatus, Posttranscriptional mechanism activity, 3, 953-957 4, 695-704 in suppression of gene expression, 1, Proliferation, cellular Polarity 215-226 granulocyte-macrophage colony- of cell, genes controlling, 3, 475-479 Potassium ion stimulating factor in, 4, 983-992 of neurons, calcineurin in, 4, 1225-1238 calcium ion-stimulated conductance of, in Proliferin of Saccharomyces cerevisiae, regulation of, epithelial cells, 1, 951-963 cation-independent mannose 6- 4, 1307-1316 cyclic AMP production stimulation by, in phosphate receptor/insulin-like Polarization neurons, 2, 13-25 growth factor II receptor binding to, of integrins on retinal pigment in exocytosis from mast cells, 1, 337-346 1, 197-213 epithelium, 2, 939-949 membrane permeability to, anthrax lethal Proline isomerases of yeast cells, extracellular cues in, 5, toxin effects on, 3, 1269-1277 cross-linking to non-proline-containing 1169-1175 tumor necrosis factor release and, 3, 451- peptide, 4, 223-232 Polarized growth 460 Promethazine in Saccharomyces cerevisiae, 3, 1025-1035 Potassium permanganate in calcium influx to T lymphocytes, 4, Polarized Madin-Darby canine kidney cells in RNA polymerase mapping on 173-184 TGN38 protein recycling in, 5, 1093- mammalian genes, 3, 1085-1094 Promoters 1103 pp6O tyrosine kinase transferrin receptor, protein binding to, 1, Polyanions in gap junction protein communication 151-164 in calcium release channel activation, 4, inhibition, 1, 989-1002 Propranolol 347-352 ppel+ gene effects on phosphatidylcholine Polyclonal antibodies of Schizosaccharomyces pombe, cell metabolism, endothelin-1 stimulated, in Drosophila centrosomal protein morphogenesis and, 4, 303-313 2, 897-903 purification, 3, 1-11 p2lrac enzyme Prostaglandin E Polyglutamylation in cytoskeleton organization, 3, 475-479 in mannose receptor upregulation, 1, of tubulin, in mouse brain neurons, 4, Preinitiation complex 403-413 615-626 in DNA polymerase III holoenzyme Prostaglandin E2 synthesis Polylactosamine glycosylation activity, 3, 953-957 neurokinin receptors in, 2, 767-779 of lysosomal associated membrane Prenylation Prostaglandin F proteins, 4, 627-635 casein kinase-1 in, 3, 275-286 effects on cellular calcium responses, 1, Polylysine gamma-subunit, in guanine nucleotide- 75-86 in fibronectin/integrin interactions binding regulatory protein Prostate cancer cells studies, 2, 951-964 distribution, 3, 49-61 amphiregulin expression stimulation in, Polymerization of rab9 protein, 4, 425-434 epidermal growth factor receptor in, of actin, 3, 1309-1315 Pre-rRNA transcription 5, 339-347 genes for, 3, 475-479 U3 snRNA-containing bodies in, 5, 955- Proteases nucleotide exchange regulation in, 3, 966 in endoplasmic reticulum, in T-cell 1015-1024 Presecretory proteins receptor chain degradation, 2, 753- in polymorphonuclear neutrophils, 3, translocation of, across endoplasmic 765 1427-1435 reticulum membrane, in yeast, 4, yeast, tyrosine localization signal in, trigger mechanisms for, 5, 313-322 931-939 disruption of, 3, 1353-1371 of tubules, in hepatocytes, extracellular Presynaptic nerve terminals Protein(s) matrix control of, 5, 1277-1280 calcium concentration regulation in, ATP-binding, in protein translocation of tubulin mitochondrial in, 3, 235-248 across endoplasmic reticulum GTP hydrolysis in, 3, 1155-1167 p21rho enzyme membrane, 2, 851-859 tau protein and, 3, 1141-1154 in cytoskeleton organization, 3, 475-479 calcium mediator, 1, 165-172

Vol. 5, December 1994 1395 Subject Index

centrosomal, from Drosophila embryo, Xenopus oogenesis and activation of, 1, 693-706 purification of, 3, 1-11 embryogenesis, 5, 921-932 in embryonic heart development, 1, dephosphorylation of, in exocytosis, 1, in cell adhesion and spreading, 4, 271- 301-313 523-530 281 activation of, correlation with import into mitochondria, ATP cyclin binding to, 3, 1279-1294 diacylglycerol production in requirements for, 5, 465-474 cyclin-dependent, dephosphorylation of, bradykinin response, 2, 229-239 mitochondrial, interactions with stress protein phosphatase 2A, in, 4, 669- alpha-type, overexpression of, urokinase- proteins, 2, 165-179 677 type plasminogen activator soluble, transport during mitosis, 1, 415- dskl, phosphorylation of, vs. cell cycle production in, 2, 491-502 424 stage, 4, 247-260 in amphibian egg activation, 1, 315-326 synthesis of dual-specificity, 3, 299-308 arachidonic acid metabolite effects on, 2, in cell-free translation system, 1, 1057- expression of, in PC12 cells, nerve 1045-1055 1067 growth factor regulation of, 5, 1225- in basic fibroblast growth factor interferon effects on, 1, 215-226 1241 activation, mitogenic potential of, 2, translocation of, across endoplasmic extracellular signal-regulated, 2, 357-371 719-726 reticulum membrane, 2, 851-859 focal adhesion calcium affinity of, 1, 166 transport of, in endoplasmic reticulum, 3, activity of, in injured endothelial cells, in crosslinking of IgE receptor with 667-676 5, 349-361 membrane skeleton, 2, 181-191 yeast microtubule-associated, v-Src protein interaction with, 5, 413- depletion of, mitogen-induced calcium identification of, 3, 29-47 421 response of, 1, 75-86 Protein 21 functional homology of, in yeasts, 4, in endothelin-1-stimulated fibroblast in cyclin/cyclin-dependent kinase 107-120 growth, 1, 379-390 complexes, 4, 897-906 FUS3, promoting autophosphorylation, in in gastric acid secretion, 2, 27-39 Protein disulfide isomerase yeast mating, 5, 297-312 in growth factor mitogenic pathway in endoplasmic reticulum, 3, 1067-1072 of hippocampus, autophosphorylation of, activity, 1, 747-761 Protein kinase(s). See also Mitogen-activated 4, 159-172 in HeLa cell spreading on substrates, 3, protein kinase(s) in insulin receptor endocytosis, factors 481-492 activation of, 3, 1329-1337 required for, 5, 539-547 identification of, 1, 165 cyclin A in, 4, 79-92 MEK-1, phosphorylation activity of, 5, inhibitors of molecular signal integration in, 3, 583- 193-201 in embryonic heart development, 1, 592 in melanocyte terminal differentiation 310-313 by phosphatase inhibition, 1, 269-278 and senescence, 5, 497-509 in exocytosis from mast cells, 1, 337- associated with metaphase spindle, 2, membrane-associated, in ADR induction, 346 861-874 1, 1015-1025 in ion channel function, 5, 485-496 cAMP-dependent microtubule-associated, in isoenzymes of, 1, 693-706 catalytic subunit of, in neurofilament phosphorylation of epidermal in lymphokine gene expression phosphorylation, 5, 161-172 growth factor-treated fibroblasts, 2, regulation, 1, 425-434 free catalytic subunit of, nuclear 663-673 mammalian, expression in translocation of, 4, 993-1002 p32cdc2 cyclin binding to, 3, 1279-1294 Schizosaccharomyces pombe, 5, 907- casein kinase I, of yeasts, dual-specificy p34cdc2 920 activity of, 5, 877-886 activation of, 3, 389-401 in neurite outgrowth, 3, 323-333 cdc2 in cec25+ regulation, 3, 73-84 in neurofilament L protein activation of, 3, 389-401 cyclin binding to, 3, 1279-1294 phosphorylation, 1, 237-248 in cdc25 phosphorylation, 4, 1337- inhibition of, by transforming growth in nuclear factor kappa B activation, 2, 1350 factor,B1, 3, 655-665 329-335 inhibition by INH protein phosphatase regulation of, 3, 299-308, 5, 989-1001 overexpression of, phosphatidylcholine type 2A, 5, 323-338 from Xenopus, phosphorylation and, 3, metabolism and, endothelin-1 effects in maturation-promoting factor 13-27 on, 2, 897-903 activation, 5, 135-145 proliferating cell nuclear antigen in platelet granule secretion, 1, 1027- mutant, in Xenopus oocyte maturation, associated with, 4, 897-906 1041 5, 587-596 protein 21 associated with, 4, 897-906 platelet-activating factor metabolite phosphorylation of, 5, 273-282 Raf, in MEK-1 protein kinase action of, 1, 13-25 in Xenopus cyclin B2 degradation, 5, phosphorylation, 5, 193-201 in talin phosphorylation, 1, 227-236 713-724 Raf-1, interference with Ras and RaplA Protein kinase C-a CDC7, of Saccharomyces cerevisiae, cell effector functions overexpression of, in Swiss/3T3 cells, cycle and, 4, 195-208 in yeast, 5, 135-145 cellular protein phosphorylation and, cdc13, in Schizosaccharomyces pombe serine/threonine, molecular cloning of, 2, 3, 1049-1056 nucleus, 4, 1087-1096 1001-1009 Protein kinase C**sub gamma cdc25 STE7, in FUS3 phosphorylation, 5, 297- inhibitory properties of, 5, 475-484 in maturation-promoting factor 312 Protein kinase II,B activation, 5, 135-145 weel, in cdc2 phosphorylation, 5, 273- A kinase anchor protein interaction with, phosphorylation site elimination in, 4, 282 3, 1215-1228 1337-1350 Protein kinase A Protein kinase N cdc25.22, in Schizosaccharomyces pombe in alkaline phosphatase release from activity of, purine analogue inhibition of, nucleus, 4, 1087-1096 cyclic AMP-resistant osteoblasts, 2, nerve growth factor receptor and, 4, cdc25-C, dephosphorylation of, protein 889-896 71-78 phosphatases in, 4, 397-411 in nuclear factor kappa B activation, 2, Protein M cdc28, v-src gene expression effects on, 5, 329-335 retention of, in Golgi apparatus, 4, 695- 283-296 Protein kinase C 704 cdk-activating, in p40Mol5 activation, in in actin reorganization, 2, 1067-1079 Protein phosphatase(s)

1396 Molecular Biology of the Cell Subject Index

alterations of, oncogenic viruses in, 2, PTK2 epithelial cells phosphorylation in, ultraviolet radiation 589-598 actin reorganization in, heavy metal ions induction of, 4, 523-530 gene of, Schizosaccharomyces pombe, cell in, 2, 1067-1079 Rapl ATPase morphogenesis and, 4, 303-313 Puff genes, DNA activation of, 3, 1437-1442 inhibition in collagenase gene expression, promoters of, in Sciara coprophila, 2, 875- RAP genes 1, 269-278 888 mammalian, expression in yeast, 1, 763- in protein kinase activation, in Xenopus Pulse-chase labeling 769 egg extract, 4, 397-411 in mitochondrial protein studies, 2, 165- RaplA protein Protein phosphatase 1 179 effector functions of, Raf-1 protein kinase in Xenopus embryonic cell cycle, 3, 687- Pupation interference with, 5, 135-145 698 DNA puff gene promoters for, 2, 875- Rapamycin Protein phosphatase 2A, Drosophila, 888 hematopoietic cell line proliferation characterization of, 3, 287-298 Purine analogues inhibition by, 3, 981-987 Protein phosphatase 2A, in protein kinase activity inhibition, nerve resistance to, of TOR1 and TOR2 in protein kinase dephosphorylation, 4, growth factor receptor and, 4, 71-78 proteins in, 5, 105-118 669-677 PlWl clone Ras, GTPase activator protein of Proteinase A autonomous replication of, 4, 1121-1132 platelet-derived growth factor receptor sorting of, in yeast, 3, 415-427 binding to, 4, 49-57 Proteinase B ras gene sorting of, in yeast, 3, 415-427 effects on oocytes, 1, 543-554 Protein-I(Y) Quercetin rasl gene high mobility group, phosphorylation of, in crosslinking of IgE receptor with mutation of, in Schizosaccharomyces 4, 669-677 membrane skeleton, 2, 181-191 pombe, 5, 613-616 Proteoglycans Quinacrine regulation of, by Schizosaccharomyces in B-cell differentiation, 1, 27-35 in crosslinking of IgE receptor with pombe gene, 2, 453-465 in collagen retention on cell surface, 4, membrane skeleton, 2, 181-191 RAS genes 1097-1108 Quinine interaction with RAP genes, 1, 763-769 exocytosis of, in parathyroid hormone tumor necrosis factor release and, 3, 451- Ras proteins release, extracellular calcium ion in, 460 activation of, 3, 583-592 5, 725-737 effector functions of, Raf-1 protein kinase heparan sulfate interference with, 5, 135-145 of syndecan 4, in focal adhesion, 5, in mitogen-activated protein kinase 183-192 Rab protein(s) activation, in NIH-3T3 cells, 4, 483- syndecans of, selective expression of, 5, complexation with GDP dissociation 493 797-805 proteins, 4, 425-434 Ras/adenylate cyclase system in myoblast-thrombospondin-1 adhesive in secretory granule localization, in AtT- of Saccharomyces cerevisiae, gene interactions, 5, 423-437 20 cells, 4, 747-756 expression in, 4, 757-765 Proteolysis Rab5 protein Ras-related GTPases of T-cell antigen receptor, 1, 907-919 as ypt5 protein homologue, 4, 583-592 activation of, 3, 1437-1442 urokinase-type plasminogen activator in, Rab9 protein in cytoskeleton organization, 3, 475-479 2, 793-803 cytosolic, complexation with GDP ras-transformed mouse mammary epithelial Prothoracic gland dissociation protein, 4, 425-434 cells of insects, calmodulin-dependent Rac proteins syndecan-1 translational expression in, 4, adenylate cyclase activity in, 1, 771- molecular cloning of, 2, 1001-1009 849-858 780 in NADPH oxidase activity regulation, 4, Rat 1217-1223 asialoglycoprotein receptor of, in Protooncogenes 1, 471-486 interferon effects on, 1, 215-226 in neutrophil NADPH oxidase activation, endocytosis, 560 4, 261-269 basophilic leukemia cells of platelet-derived growth factor and, 1, rad genes actin polmerization in, trigger Proximal tubular cells mutation of, in Schizosaccharomyces mechanisms for, 5, 313-322 angiotensin II-treated, collagen secretion pombe, 5, 147-160 IgE receptor crosslinking on, 2, 181- from, 2, 219-227 Radiation 191 P-selectin (CD62, GMP-140, PADGEM) of apoptotic lymphoblasts from bursa of signal transduction in, isoprenoid cytoplasmic domain of, in sorting into Fabricius, 5, 763-772 pathway activity in, 2, 627-640 regulated pathway of secretion, 3, cell cycle checkpoint and feedback bladder carcinoma cells of 309-321 control element damage in, in acidic fibroblast growth factor effects fate of, after expression on plasma Saccharomyces pombe, 5, 147-160 on, 1, 975-988 membrane, 4, 791-801 Raf-1 protein fibroblast growth factor alternate Pseudohyphae in mitogen-activated protein kinase splicing in, epithelial-mesenchymal of Saccharomyces cerevisiae, symmetric activation, in NIH-3T3 cells, 4, 483- transition in, 5, 851-862 cell division in, 5, 1003-1022 493 hemidesmosomes in, integrin function Pseudopods Raf protein kinase in, 2, 427-438 formation of, in amoebas, myoA gene in, in MEK-1 protein kinase bladder epithelial cells of, integrin 4, 233-246 phosphorylation, 5, 193-201 interaction with, 4, 871-884 p67SRF (serum response factor) Raf-1 protein kinase brain of in gene modulation, in Gl period of cell interference with Ras and RaplA effector drug bindings sites on, 3, 613-619 cycle, 2, 575-588 functions, in yeast, 5, 135-145 A kinase anchor protein distribution in, PT 18 cells Raf serine kinase 3, 1215-1228 proliferation of, immunophilin ligands activation of, 3, 583-592 calcium localization in, after mobilization, effects on, 3, 981-987 Ramos Burkitt's lymphoma cell line 3, 621-631

Vol. 5, December 1994 1397 Subject Index

dorsal root ganglion neurons of, calcium carcinoma cell adherence, 1, 249-257 in retinoic acid-treated neuroblastoma releasing agents effects on, 3, 1415- cation-independent mannose 6- cells, 2, 1021-1033 1425 phosphate/insulin-like growth factor macrophage colony-stimulating factor extracellular signal-regulated kinases in, II, 1, 197-218 activating mutations effects on, 5, 81- 2, 357-371 C3b (CR1), internalization of, in 95 glucocorticoid receptors of, neutrophils, 2, 41-55 mannose, prostaglandin E upregulation characterization of, 3, 1245-I257 cell adhesion, in laminin isoform of, 1, 403-413 hepatic lectin-1 of, in endocytosis, 1, recognition, 5, 203-215 matrix, steroid-induced suppression of, 2, 471-486 c-fms oncogene, cDNA of, 3, 761-773 1-11 hepatocytes of collagen nerve growth factor cytokine receptor regulation in, 3, 103- clustering of, in HeLa spreading on antibodies to, 2, 691-697 112 substrates, 3, 481-492 lateral diffusion of, 1, 605-614 hormone-induced calcium signal on fibroblasts, wound healing and, 2, protein kinase activity of, purine- coordination in, 3, 113-121 1035-1044 analogue-sensitive, 4, 71-78 hepatoma cells of, connexin43 gene for integrins, 2, 905-913 tyrosine kinase as, 2, 685-690 transcription regulation in, 3, 839- cyclic adenosine diphosphate-ribose, 1, neurokinin, physiological actions of, 2, 850 279-290 767-779 kidney cells of, nucleogenesis in, U3 cyclic AMP neurotrophin snRNA-containing bodies in, 5, 955- in calcium ion influx promotion, in autophosphorylation of, inhibition of, 966 Dictyostelium discoideum, 4, 283-292 3, 677-686 kidney fibroblasts of, Gi protein in, a in Dictyostelium, signaling pathway in melanoma invasion, 4, 1205-1216 subunit(s) of, subcellular distribution activation in, 5, 703-711 oocyte, phosphorylation of, vanadate of, 2, 1097-1113 dihydropyridine, distribution of, in effects on, 2, 317-327 liver epithelial cells of, gap junction transverse tubule/sarcoplasmic pheromone, of Saccharomyces cerevisiae, communication disruption in, reticulum junctions, 5, 1105-1118 2, 439-452 epidermal growth factor in, 3, 865- epidermal growth factor. See under in phosphatidylcholine hydrolysis, 2, 874 Epidermal growth factor 299-303 liver regeneration in, transforming estrogen phosphomannosyl, cholesteryl ester growth factor-j isoforms in, 2, 535- nuclear localization regulation in, 1, metabolism and, 1, 661-674 548 291-299 plasminogen activator, inhibitor action mitogen-activated protein kinases of, 3, thyroid hormone receptor activity and, on, 1, 1043-1056 63-71 2, 565-574 platelet-derived growth factor, 1, 556- RAW 269 cells fibroblast growth factor, alternate splicing 558, 1, 561. See under Platelet- tumor necrosis factor release from, in, epithelial-mesenchymal transition derived growth factor membrane potential modulation of, in, 5, 851-862 hypertension and, 1, 821-831 3, 451-460 fibronectin, overexpression in K562 cell retinoic acid RBL 2H3 cells variants, 1, 637-648 keratin gene transcription and, 1, 965- proliferation of, immunophilin ligands glucocorticoid, nuclear localization 972 effects on, 3, 981-987 regulation in, 1, 291-299 thyroid hormone receptor activity and, signal transduction in, isoprenoid glycoprotein, in endocytosis, 1, 471-486 2, 565-574 pathway activity in, 2, 627-640 granulocyte-macrophage colony- ryanodine RC2A leukemia cells stimulating factor, 1, 327-335, 3, activation of, heparin in, 4, 347-352 plasminogen activation in, alpha2- 535-544 distribution of, in transverse tubule/ macroglobulin effects on, 2, 1057- guanylyl cyclase, 5, 1-5 sarcoplasmic reticulum junctions, 5, 1065 immunoglobulin E 1105-1118, Saccharomyces cerevisiae RCC1 gene in actin polymerization, 5, 313-322 pheromone, endocytosis of, 4, 511- loss of, cdc25C protein and, 3, 1373- crosslinking with membrane skeleton, 521 1388 2, 181-191 serotonin, in starfish egg activation, 1, RCC1 protein in signal transduction, isoprenoid 453-462 human, vs. yeast SRM1 protein, 2, 781- pathway activity in, 2, 627-640 serotoninlA, activation of, DNA synthesis 792 inositol trisphosphate, 1, 279-290 potentiation by, 3, 961-969 Receptor(s). See also Integrin(s) insulin signal recognition particles, in acetylcholine, activation of, small cell endocytosis of, kinase-dependent, 5, Saccharomyces cerevisiae, 3, 895-911 lung carcinoma inhibition by, 2, 373- 539-547 signal sequence, in protein transfer across 381 tyrosine kinase activity of, lipid effects endoplasmic reticulum membrane, 2, adenosine, in actin polymerization, 5, on, 2, 65-72 851-859' 313-322 integrin, focal contact localization of, 4, steroid, characterization of, 3, 1245-1257 a-adrenergic, DNA synthesis and, 1, 593-604 T-cell antigen, proteolysis of, 1, 907-919 445-451 interaction with ligands, in membrane thyroid hormone asialoglycoprotein, fatty acyl-coenzyme A traffic regulation, 3, 1317-1328 isoforms of, 2, 565-574 regulation of, in hepatocytes, 5, 227- interleukin-6, regulation of, 3, 103-112 keratin gene transcription and, 1, 965- 235 interleukin-2, tyrosine phosphorylation 973 B cell antigen, stimulation by lyn gene of, 2, 73-85 trafficking of, endosome acidification and, products, 2, 979-987 lamin B, vs. Schizosaccharomyces pombe 4, 1251-1266 basement membrane, retinal pigment stsl+ gene product, 3, 263-273 transferrin, 1, 369-377 epithelium integrin polarization on, laminin recruitment for endocytosis, 4, 715-727 2, 939-949 a6,B1 integrin structural variants transforming growth factor-#, in cAMP, in Dictyostelium, 3, 1229-1234 interactions with, in macrophage choriocarcinoma cells, 3, 1295-1307 second messenger regulation of, 3, functional modulation, 5, 679-690 transforming growth factor-a, ligand 603-612 in melanoma metastasis, 2, 805-817 affinity for, 2, 599-612

1398 Molecular Biology of the Cell Subject Index

trkA, in nerve growth factor binding, 5, differentiation, bone morphogenetic carboxylate synthase gene expression 549-563 proteins effects on, 3, 189-196 and, 4, 363-373 tyrosine kinase, in PC12 cells, epidermal in epidermal growth/differentiation, 1, Rough endoplasmic reticulum growth factor receptor 791-809 as classical subcompartment, 3, 1067- desensitization in, 4, 737-746 in neuroblastoma cell differentiation, 1072 urokinase plasminogen activator integrin expression and, 2, 1021- Rous sarcoma virus in extracellular matrix degradation, 2, 1033 transforming protein of, in Saccharomyces 793-803 receptor for cerevisiae growth inhibition, 5, 283- on keratinocytes, 1, 843-852 keratin gene transcription and, 1, 965- 296 vitronectin, on fibroblasts, 2, 1035-1044 973 Rous sarcoma virus-transformed cells Receptor tyrosine kinase thyroid hormone receptor activity and, chick lens epithelial, intercellular in neurotrophin receptor 2, 565-574 adherens-type junction modulation autophosphorylation inhibition, 3, transforming growth factor induction by, in, 2, 105-120 677-686 1, 87-97 chicken embryo fibroblasts, integrins in, Recycling activity in urokinase-type plasminogen activator 2, 271-283 of transferrin receptor, 1, 369-377 expression, 2, 285-297 myelin basic protein kinases in, activation REF-52 cells Retrovirus envelope protein maturation of, 3, 1329-1337 cAMP-dependent protein kinase free glucocorticoids in, 1, 531-541 Rsk serine kinase catalytic subunit injection into, Rho GTPase activation of, 3, 583-592 nuclear translocation of, 4, 993-1002 activation of, 3, 1437-1442 RU 24969 small nuclear ribonucleoprotein particle Rholp protein in DNA synthesis, serotoninlA receptor localization in, 3, 555-569 prenylation of, yeast growth and, 4, activation and, 3, 961-969 rel-like proteins 1017-1025 RU 28362 regulation of, signal transduction Ribonuclease glucocorticoid receptor binding of, 3, pathway for, 4, 767-771 in granulocyte-macrophage colony- 1245-1257 Replication stimulating factor receptor Ruthenium red abnormalities of, in Schizosaccharomyces expression, 3, 535-544 brain calcium uptake and, 1, 781-790 pombe minichromosome loss, 5, Ribonucleoproteins in intracellular calcium release, 2, 513- 1145-1158 small nucleolar, organization of, 5, 1289- 522 autonomous 1299 in mobilized calcium localization, 3, 613- of chromosomal DNA fragments, 4, Ribonucleotide reductase 619 1121-1132 expression of, in Escherichia coli, 3, 1095- Ryanodine receptor in Schizosaccharomyces pombe, physical 1105 activation of, heparin in, 4, 347-352 mapping of, 5, 839-849 Ribosomes distribution of, in transverse tubule/ Replication map targeting to endoplasmic reticulum, by sarcoplasmic reticulum junctions, 5, of Saccharomyces cere,isiae chromosome signal recognition particle, 5, 887- 1105-1118 III circular derivative, 3, 999-1013 897 Replicative polymerases Rice sliding clamp of, 3, 953-957 1-aminocyclopropane- 1 -carboxylate Research synthase in, genes encoding, 4, 363- S phase basic, National Institutes of Health and, 373 of cell cycle, p34 CDC2 protein kinase 5, 267-272 Ricin activation in, 3, 389-401 in human disease, basic science in, 3, in a(1,3)fucosyltransferase studies, 2, 989-1000 S100 protein 837-838 characterization of, 1, 166-167 Reticulocytes RLB-2H3 cells protein kinase C**sub gamma inhibitory SAC6 gene mitogen-activated protein kinase in yeast, null mutation of, 4, 459-468 activation in, 4, 781-790. properties in, 5, 475-484 Retina RNA $accharomyces cerevisiae cadherins in, 2, 261-270 antisense, of calmodulin, cytokinesis actin in inhibition by, 3, 1403-1413 cytoskeleton organization in, END3 Retinal pigment epithelium gene in, 5, 1023-1037 polarized distribution of integrins on, 2, messenger. See Messenger RNA small nuclear, in Xenopus egg extract phalloidin-binding site of, 4, 1277- 939-949 1294 Retinoblastoma susceptibility gene product coiled body assembly, 5, 633-644 RNA binding protein adenylyl cyclase-associated protein of, ElA protein binding to, 4, 353-361 cap gene characterization of, 3, 167- interaction with adenovirus early cytosolic aconitase as, 4, 1-5 180d response gene polypeptides, 2, 479- RNA1 gene product Ancl protein of, similarity to human 489 homologue of, in Schizosaccharomyces leukemia proteins, 5, 617-632 Retinoblastoma tumor suppressor protein pombe, characterization of, 4, 569- binding protein localization studies in, 5, relationship to myogenic determination 581 1119-1127 protein MyoD, 4, 705-713 RNA polymerase budding of Retinoblastoma tumor susceptibility gene mapping of, on mammalian genes, 3, actin structure and function in, 4, product 1085-1094 1277-1294 transforming growth factor inhibition of RNA polymerase II, Drosophila B52 protein minichromosomes from, centromere p34cdc2 3, 655-665 interaction with, 5, 71-79 function on, 4, 859-870 Retinoblastoma-related protein and related RNA-binding domains calcium-ATPase homologue (PMR1) of, proteins of nucleolin, in nucleolar targeting, 4, localization in Golgi system, 3, 633- transcriptional repression by, 4, 389-396 1239-1250 654 Retinoic acid Roots casein kinase I isoforms of, dual-specificy in embryonal carcinoma cell hypoxia of, 1-aminocyclopropane-1- activity of, 5, 877-886

Vol. 5, December 1994 1399 Subject Index

cell cycle of, protein kinase activity in, 4, signal recognition particle receptors in, 3, mitosis of, protein phosphatase effects 195-208 895-911 on, 4, 337-345 cell polarization in, extracellular cues in, signal transduction of, CDC gene morphogenesis of, 5, 613-616 5, 1169-1175 mutation in, 1, 391-401 mutants of, 5, 613-616, nda gene of, chromosome III circular derivative of, SRM1 protein of, vs. human RCC1 functions of, 4, 1003-1015 replication map of, 3, 999-1013, protein, 2, 781-792 nucleus of, cyclin B distribution in, 4, COX2 gene of, mRNA alteration in, STE6 protein in, intracellular trafficking 1087-1096 4, 1327-1335 of, 5, 1185-1198, tcp gene mutations protein kinases of cytoskeletal genes of, null mutation of, 4, in, 5, 1065-1080, TORI and TOR2 cell cycle stage and, 4, 247-260 459-468 genes of, characterization of, 5, 105- functional homology of, 4, 107-120 endocytosis in, END3 gene in, 5, 1023- 118 protein phosphatase gene of, cell 1037 /3-tubulin gene of, mutational analysis of, morphogenesis and, 4, 303-313 endoplasmic reticulum of 5, 29-43 rasl function in, regulation of, 2, 453- polypeptide translocation into, 4, 931- tubulin of, in yeast-microtubule- 465 939 associated protein identification, 3, replication sites in, physical mapping of, protein translocation into, 4, 919-930 29-47 5, 839-849, RNA1 gene product, exocytic pathway of, protein degradation vacuolar protein sorting in, 3, 415-427, 3, homologue of, characterization of, 4, in, 4, 729-736 DecG 569-581 FAR1 phosphorylation in, alpha-factor Vma2l membrane protein in, in sexual differentiation of, 3, 721-734, effects on, 3, 445-450 hydrogen ion-ATPase complex stsl+ gene of, in drug sensitivity, 3, genes of assembly, 5, 1039-1050 263-273, ypt genes of, in exocytosis, in casein kinase-1 encoding, 3, 275- zygotes of, mitochondrial sorting patterns 4, 583-592, 4, 1069-1076 286 in, 4, 21-36 Schwann cells cyclin, 3, 805-818 Salivary gland chromosomes glia maturation factor ,B effects on, 1, geranylgeranyltransferase I defect in, of Sciara coprophila, DNA puff genes in, 741-746 GTPase prenylation and, 4, 1017- 2, 875-888 Sciara coprophila 1025 SaOS-2 osteoblasts DNA puff genes in, 2, 875-888 Golgi complex of, cell cycle of, 3, 789- alkaline phosphatase release by, Science education, 3, 959-960 .803 inhibition of, 2, 889-896 reform of, 3, 1195-1197 growth inhibition in, aberrant sar gene Scrapie prion proteins phosphorylation in, 5, 283-296 in yeast microtubule-associated protein synthesis of, 3, 851-863 3-hydroxy-3-methylglutaryl coenzyme A synthesis, 3, 29-47 Sea urchin reductase feedback regulation in, 5, sarl gene dynein genes in, phylogeny and 655-665 of Schizosaccharomyces pombe, 2, 453-465 expression of, 5, 57-70 mammalian RAP gene expression in, 1, Sarcoplasmic reticulum, 3, 1067-1072 eggs of 763-769 junction with transverse tubules, activation of, by cGMP, 3, 373-383 mating of organization of, in excitation- adenosine diphosphoribosyl cyclase FUS3 mutations in, 5, 297-312 contraction coupling, 5, 1105-1118 effects on, 2, 203-209 projection formation in, 3, 429-444 Scaffold protein, RNA1 gene product as, 4, guanosine 5'-thiotriphosphate effects nuclear division of, espl gene in, 3, 1443- 569-581 on, 2, 121-133 1454 SCC-13 cells embryos of, mitosis in, okadaic acid nuclear mRNA accumulation in, transforming growth factor effects on, 1, effects on, 2, 391-402 nucleolar fragmentation in, 5, 1253- 791-809 SpCoell gene of, expression in injury, 3, 1263 Schizosaccharomyces pombe 403-414 nuclear protein localization in, 3, 875-893 adenylyl cyclase of, analysis of, 2, 155- sperm of, motility of peroxisome biogenesis in, 4, 1351-1359 164 dynein IC1 peptide in, 5, 1051-1063 pheromone receptors of adenylyl cyclase-associated protein of, sec genes endocytosis of, 4, 511-521 cap gene characterization of, 3, 167- in dipeptidylaminopeptidase B insertion genetic analysis of, 2, 439-452 180d into endoplasmic reticulum, 3, 129- polarity of, regulation of, 4, 1307-1316 casein kinase I isoforms of, dual-specificy 142 polarized growth in, sites for, 3, 1025- activity of, 5, 877-886, cedl4 gene Secl2 protein 1035 of, in septum formation, 4, 531-539 formation of, in yeast cells, binding protease of, tyrosine localization signal cell cycle of protein relocalization and, 5, 1119- in, disruption of, 3, 1353-1371 checkpoint identification and 1127 protein import into mitochondria, characterization in, 5, 147-160 Sec23 protein essential inner membrane protein mutant calmodulin kinase II effects on, in reticulum vesicle for, 5, 529-538 5, 785-795 endoplasmic protein kinases of, functional homology centromeres of, 3, 819-835 budding, 3, 667-676 of, 4, 107-120 function of, DNA requirements for, 5, sec6lp gene pseudohyphae of, symmetric cell division 747-761 isolation of, 3, 129-142 in, 5, 1003-1022 DNA polymerases of, cell cycle Sec63p-BiP complex Ras effector functions in, RAF-1 protein expression of, 4, 145-157 of Saccharomyces cerevisiae, mutations kinase interference with, 5, 173-181 Golgi apparatus of, c 1,2 affecting, 5, 933-942 Ras/adenylate cyclase system of, gene galactosyltransferase activity Sec63 protein expression in, 4, 757-765 localization in, 5, 519-528 interactions with Kar2 protein, in yeast replication sites in, physical mapping of, mammalian protein kinase C expression endoplasmic reticulum, 4, 1145-1159 5, 839-849, RNA1 gene product of, in, 5, 907-920 sec65 gene vs. Schizosaccharomyces pombe gene mammalian RAP gene expression in, 1, isolation of, 3, 129-142 product, 4, 569-581, sec71-1 and 763-769 mutation of, suppression of, 4, 919-930 sec72-1 mutations in, 5, 933-942 minichromosome loss in, 5, 1145-1158 Sec66 protein

1400 Molecular Biology of the Cell Subject Index

in polypeptide translocation in yeast in gene modulation, in Gl period of cell Simian kidney cells endoplasmic reticulum, 4, 931-939 cycle, 2, 575-588 myosin filament assembly in, 4, 1051- sec71-1 and sec72-1 genes Serum response genes 1067 mutations of, in Saccharomyces cerevisiae, characterization of, 5, 375-388 Simian virus 40 5, 933-942 Sex determination protein phosphatases alterations by, 2, Second messengers in Caenorhabditis elegans, tra-2 gene in, 3, 589-598 in angiotensin II-induced tubular 461-473 Single-stranded antisense epithelial hypertrophy, 2, 219-227 Sex hormones oligodeoxynucleotides in bradykinin response, 2, 229-239 syndecan suppression by, 2, 1-11 against small nuclear RNAs, in in cAMP receptor regulation, on Sexual differentiation lampbrush chromosome loop Dictyostelium cells, 3, 603-612 of Schizosaccharomyces pombe, 3, 721-734 transcription, 3, 249-261 in crosslinking of IgE receptor with of yeasts, protein kinase homology in, 4, Skeletal muscle membrane skeleton, 2, 181-191 107-120 excitation-contraction coupling in, cyclic adenosine diphosphate-ribose Shionogi 115 mouse mammary tumor cells transverse tubule/sarcoplasmic action as, 1, 279-290 steroid-induced syndecan suppression in, reticulum junction organization in, 5, dual, in pheochromocytoma cell gene 2, 1-11 1105-1118 expression, 3, 941-951 Signal integration Skeletal myoblasts in endothelin-1 activity, 1, 379-390 integrins in, 5, 389-393 adhesive interactions with enzymes of, egg-specific NADase, 2, 193- Signal recognition particle thrombospondin-1, 5, 423-437 202, 2, 203-209, 2, 211-218 activity of, GTP role in, 5, 887-897 SKF-10 047 (N-allylnormetazocine) in HeLa cell spreading on substrates, 3, receptors for, in Saccharomyces cerevisiae, biologically active binding sites for, on 481-492 3, 895-911 lung cancer cells, 3, 613-619 inositol trisphosphate as, 1, 279-290 Signal sequence receptor Skin in phosphorylation, 3, 583-592 in protein transfer across endoplasmic fibroblasts in, connective tissue growth Secretagogues reticulum membrane, 2, 851-859 factor gene expression in, 4, 637-645 calcium ion changes vs. catecholamine Signal sequence recognition Skin cancer release and, 1, 683-691 GTP role in, 5, 887-897 transforming growth factor-a in, 2, 613- sodium metabolism and, 1, 259-268 Signal transducing protein 625 Secreted protein acidic and rich in cysteine gpl3O, regulation of, 3, 103-112 S6-kinase (SPARC), Caenorhabditis elegans Signal transduction growth factor effects on, 1, 821-831 homologue of, functions of, 4, 941- chicken embryo kinase 5 in, 2, 523-534 Sliding clamp 952 in Dictyostelium, cyclic AMP receptors in, of DNA polymerase III holoenzyme, 3, Secretion 5, 703-711 953-957 from platelet granules, factors affecting, in embryonic heart development, 1, 301- SIP20 1, 1027-1041 313 in ADR induction, 1, 1015-1025 Secretory granules extracellular signal-regulated kinases in, Slug size of AtT-20 cells, localization of, rab 2, 357-371 of yeasts, cell adhesion molecule effects proteins in, 4, 747-756 focal adhesion kinase in, 5, 413-421 on, 1, 715-729 Secretory pathways in hematopoietic cells, Small cell lung carcinoma mitosis effects on, 1, 415-424 immunosuppressive drugs effects on, cell cycle inhibition of, acetylcholine Selectins 3, 981-987 receptor activation in, 2, 373-381 fate of, after expression on plasma heterotrimeric G proteins and, 3, 1317- Small heat shock proteins membrane, 4, 791-801 1328 genes of, expression in Caenorhabditis sem-5 gene immunoglobulin E receptor-mediated, elegans, 3, 221-233 of Caenorhabditis elegans, replacement of, isoprenoid pathway in, 2, 627-640 Small nuclear ribonucleoprotein particles 4, 1175-1188 interleukin-2 receptor phosphorylation in chromosome transcription, 3, 249-261 Septum formation and, 2, 73-85 localization of, in transformed and in Schizosaccharomyces pombe, cedl4 gene in lymphocytes, ultraviolet radiation nontransformed cells, 3, 555-569 in, 4, 531-539 effects on, 4, 523-530 Small nuclear RNA Serine kinases mechanisms of, in cytokines, 4, 135-144 in Xenopus egg extract coiled body activation of, molecular signal integration myelin basic protein kinases in, 3, 1329- assembly, 5, 633-644 in, 3, 583-592 1337 Small nucleolar ribonucleoproteins Serine/threonine protein kinase nerve growth factor receptors in, 2, 691- organization of, 5, 1289-1299 molecular cloning of, 2, 1001-1009 697 Smooth endoplasmic reticulum Serotonin neurokinins in, 2, 767-779 as classical subcompartment, 3, 1067- in DNA synthesis by platelet integrin, 3, 989-998 1072 a-adrenergic agonists effects on, 1, in rel-like protein regulation, 4, 767-771 Smooth muscle 445-451 by steroid hormones, 1, 291-299 actin gene of, 3, 1073-1083 serotoninlA receptor activation and, 3, by steroid receptor proteins, 3, 1245- cytosolic calcium regulation in, in 961-969 1257 response to extracellular ATP, 3, in starfish egg activation, 1, 453-463 tyrosine kinase in, isoprenoid pathway 493-505 SerotoninlA receptors activity in, 2, 627-640 vascular, response to transforming activation of, DNA synthesis potentiation in yeasts growth factor-beta, age-related by, 3, 961-969 CDC gene mutation in, 1, 391-401 dysfunction of, 4, 315-322 Serum FUS3 mediation of, 4, 495-510 Smooth muscle cells fibroblast stimulation with, 2, 229-239 protein kinase conservation in, 4, 107- endothelin stimulation of, 1, 649-659 Serum growth factors 120 growth factor stimulation of, 1, 821-831 in vinculin gene expression induction, 1, SIK cells laminin in, 1, 731-740 621-636 cell cycle control protein levels in, 4, 185- platelet-activating factor metabolite Serum response elements/factors 194 action on, 1, 13-25

Vol. 5, December 1994 1401 Subject Index

thrombin mitogenic effects on, 1, 453- of amphibian germinal vesicles, human nonhematopoietic cells and, 1, 359- 463 p80-coilin targeted to, 5, 1119-1127 367 Smsl protein Sphingosine myosin II phosphorylation and, 3, 1037- in protein import into mitochondria, in in amphibian egg activation, 1, 315-326 1048 Saccharomyces cerevisiae, 5, 529-538 in crosslinking of IgE receptor with neurotrophin receptor Snurposomes membrane skeleton, 2, 181-191 autophosphorylation and, 3, 677- transcription in, small nuclear RNA in protein kinase inhibition, cell 686 effects on, 3, 249-261 spreading and, 4, 271-281 as protein kinase inhibitor, in tumor cell Sodium dodecyl sulfate spil protein adhesion, 2, 1045-1055 sensitivity to, Schizosaccharomyces pombe of Schizosaccharomyces pombe, mitosis sensitivity to, Schizosaccharomyces pombe stsl+ gene in, 3, 263-273 and, 4, 337-345 stsl+ gene in, 3, 263-273 Sodium fluoride Spinal cord STE2 gene in prothoracic gland function, 1, 771-780 extracellular signal-regulated kinases in, pheromone receptor encoded by, 2, 439- Sodium ion 2, 357-371 452 cellular entry of, insulin-sensitive ion Spindles STE gene expression channel for, 5, 485-496 of Chinese hamster ovary cells, in yeast gene mutation, 1, 391-401 cytosolic free, flux of, 1, 259-268 microtubule-associated proteins in, 2, STE6 protein membrane permeability to, anthrax lethal 861-874 of Saccharomyces cerevisiae, intracellular toxin effects on, 3, 1269-1277 defects of, in espl mutation, 3, 1443- trafficking of, 5, 1185-1198 Sodium orthovanadate 1454 STE7 protein kinase brain calcium uptake and, 1, 781-790 formation and maintenance of, 3, 1259- of Saccharomyces cerevisiae, homology Sodium-potassium ATPase 1267 with Schizosaccharomyces pombe distribution of, on retinal pigment microtubule flux in, independence of, 5, protein kinases, 4, 107-120 epithelium, 2, 939-949 217-226 STE11 protein kinase Sodium-potassium pump Spiperone of Saccharomyces cerevisiae, homology in gastric cells, 1, 259-268 in DNA synthesis, serotoninlA receptor with Schizosaccharomyces pombe Sodium-potassium-ATPase glycoprotein activation and, 3, 961-969 protein kinases, 4, 107-120 receptor hybrid spkl protein kinase STE12 transcription factor in endocytosis, 1, 471-486 of Schizosaccharomyces pombe, homology phosphorylation of, FUS3 in, 4, 107-120 Somatic cells with Saccharomyces cerevisiae protein 1-Stearoyl phosphatidate mitogen-activated protein kinase kinases, 4, 107-120 mitogenic activity of, 2, 57-64 activation in, 4, 781-790 Splicing components Steel loci Sorbitol exclusion of, in spermatogenesis, 5, 1341- of c-kit ligand, 3, 349-362 sensitivity to, Schizosaccharomyces pombe 1352 Steroid(s) stsl+ gene in, 3, 263-273 SPRIOI gene signal transduction by, 1, 291-299 Sorcin in Saccharomyces cerevisiae growth, 3, syndecan suppression by, 2, 1-11 characterization of, 1, 167 895-911 Steroid receptor proteins SPARC, Caenorhabditis elegans homologue Spreading characterization of, 3, 1245-1257 of, functions of, 4, 941-952 of cells, on fibrinogen, platelet integrin Steroidogenesis SpCoell gene expression and, 3, 989-998 prothoracic gland regulation of, 1, 771- expression of, in injury, 3, 403-414 of HeLa cells, arachidonic acid 780 Spec proteins metabolites in, 3, 481-492 Stimulus-response coupling characterization of, 1, 166 sqt-1 gene, dpy gene interaction with, 4, in calcium homeostasis. See Calcium Specific antigen 803-817 mediator proteins in interleukin-4 gene expression, 1, 425- Squamous cell carcinoma cells Stomach mucosa cells 434 transforming growth factor in, 1, 791- vascular permeability factor expression Speckled distribution 809, 2, 613-625 in, 3, 211-220 of small nuclear ribonucleoprotein Src SH2 domain Streptolysin 0, cells permeabilized with, 1, particles, cell transformation and, 3, focal adhesion kinase binding to, 5, 413- 615-620 555-569 421 signal transduction in, 2, 627-640 Sperm SRM1 protein of yeast Stress, Escherichia coli dnaJ synthesis in, 4, bindin protein of, peptides derived from, vs. human RCC1 protein, 2, 781-792 555-563 in species-specific fertilization Starfish eggs/oocytes Stress fibers inhibition, 4, 375-387 activation of, serotonin in, 1, 453-463 in myosin II phosphorylation, 3, 1037- calcium transient induced by, at cell-free translation system preparation 1048 fertilization, 2, 121-133 from, 1, 1057-1067 Stress proteins. See also Heat shock egg activation mechanism of, 1, 453-463 maturation of, effectors for, 4, 1027-1034 protein(s) motility of, dynein IC1 peptide in, 5, meiosis of, regulation of, 4, 1295-1306 in endoplasmic reticulum, 4, 1109-1119 1051-1063, Xenopus, inositol 1,4,5- START-arrest mutants interactions with mitochondrial proteins, trisphosphate mass changes in, in yeast, 1, 403-413 2, 165-179 during fertilization, 4, 435-443 Staurosporine Strongylocentrotus Sperm factor in calcium influx to T lymphocytes, 4, bindin peptides derived from, in species- in calcium release, in dorsal root ganglion 173-184 specific fertilization inhibition, 4, neurons, 3, 1415-1425 in CD4 expression modulation, 2, 95-103 375-387 Spermatocytes in crosslinking of IgE receptor with eggs of, pore formation in, 1, 65-74 transcription cessation in, splicing membrane skeleton, 2, 181-191 SpCoell gene expression in, 3, 403-414 components excluded in, 5, 1341- in embryonic heart development, 1, 301- stsl+ gene 1352 313 of Schizosaccharomyces pombe, in drug Sphere organelles leukocyte integrin activity on sensitivity, 3, 263-273

1402 Molecular Biology of the Cell Subject Index

Subtraction cloning T cell(s) with fibronectin, in collagenase gene in T cell developmental study, 3, 761-773 activation of, phospholipase D activity in, expression regulation, 5, 439-453 Succinate 2, 841-850 variants of, characterization of, 2, 927- in exocytosis from mast cells, 1, 337-346 in antigen processing, 1, 500-501 938 Sucrose calcium influx to, 4, 173-184 Tendon in anthrax lethal toxin inhibition, 3, CD2, lymphocyte function-associated tenascin variants in, 2, 927-938 1269-1277 antigen 3 binding to, 3, 157-166 Teratocarcinoma cells Suicide CD4, bryostatin effects on, 2, 95-103 urokinase-type plasminogen activator cell, blocking of, extracellular matrix in, 4, development of, subtraction cloning expression in, 2, 285-297 953-961 study of, 3, 761-773 Teratogens Sulfate granulocyte-macrophage colony- retinoic acid as, interaction with bone in exocytosis from mast cells, 1, 337-346 stimulating factor genes in morphogenetic proteins, 3, 189-196 Sulfhydryl compounds calcineurin activation of, 5, 119-128 Testis as protease inhibitors, in T-cell receptor helper extracellular signal-regulated kinases in, chain degradation studies, 2, 753- interleukin-2 receptor phosphorylation 2, 357-371 765 and, 2, 73-85 Testosterone Superoxide type II, interleukin-4 gene expression syndecan suppression by, 2, 1-11 in, 4, 261-269 regulation in, 1, 425-434 Tetracaine formation of, Rac proteins localization, 3, 613- Suramin interleukin-2 receptor phosphorylation in mobilized calcium basic fibroblast growth factor mitogenic and, 2, 73-85 619 activity and, 2, 719-726 leukemic, mitogen-induced calcium ion 12-0-Tetradecanoyl phorbol-13-acetate oscillations in, 1, 99-112 fibroblast stimulation with, 2, 229-239 SV40-transformed marrow stromal cells nuclear factor kappa B activation in, 2, genes inducible by, protein kinase C collagen gene transcription regulation in, 329-335 overexpression effects on, 2, 491-502 1, 487-498 phosphorylation in, ultraviolet radiation interactions with thapsigargin, in gastric Swainsonine, in mannosidase inhibition, 1, induction of, 4, 523-530 acid secretion, 2, 27-39 531-541 receptors of, protease degradation of, in Tetradecanoyl phorbol-13-acetate in influenza virus hemagglutinin endoplasmic reticulum, 2, 753-765 effects on endothelin-1 activity, 1, 379- modification study, 2, 549-553 triple negative, subtraction cloning 390 Swiss 3T3 cells characterization of, 3, 761-773 in interferon-induced gene expression actin reorganization in, heavy metal ions T cell antigen receptor/CD3 complex inhibition, 1, 707-713 in, 2, 1067-1079 in phospholipase D activation, 2, 841- mitogenic signal pathways of, 1, 747-761 mitogen effects on, 1, 75-86, 1, 747-761 850 in vinculin gene expression induction, 1, myosin II phosphorylation in, 3, 1037- 3T3 cells. See NIH 3T3 cells 621-636 1048 T3 nuclear receptor Tetradecanoylphorbol acetate Sympathetic neurons keratin gene transcription and, 1, 965- action of, on spontaneously immortalized cyclic AMP production in, agonist effects 973 keratinocytes, 4, 185-194 on, 2, 13-25 Talin Tetraethylammonium synag7 gene product modulation of, in Rous sarcoma virus- tumor necrosis factor release and, 3, 451- in cAMP receptor regulation, 3, 603-612 modified chick lens cells, 2, 105-120 460 Synaptophysin phosphorylation of, phorbol ester and, 1, N,N,N'N'-Tetrakis(2-pyridylmethyl)ethy- characterization of, 1, 167 227-236 lenediamine Synaptosomes Tartrate in actin reorganization modulation, 2, in calcium cytosolic concentration in exocytosis from mast cells, 1, 337-346 1067-1079 regulation, 3, 235-248 Tau protein TGN proteins, recycling of Syndecan(s) in neurite outgrowth and stabilization, 5, with cell surface, 4, 93-105 in B-cell differentiation, 1, 27-35 863-875 in Madin-Darby canine kidney cells, 5, of heparan sulfate proteoglycans, in tubulin assembly, 3, 1141-1154 1093-1103 expression of, selective patterns in, 5, Taxol Thapsigargin 797-805 effects on glutamylation of mouse brain in calcium ion regulation, 2, 915-925 steroid-induced suppression of, 2, 1-11 neurons, 4, 615-626 effects on calcium influx to T Syndecan-1 in viral glycoprotein transport, 1, 921- lymphocytes, 4, 173-184 cytoplasmic tail deletions in, transport 936 in gastric acid secretion, 2, 27-39 and targeting effects of, 5, 1325- in yeast microtubule-associated protein Thiabendazole 1339 identification, 3, 29-47 sensitivity to, Schizosaccharomyces pombe translational expression of, in Ha-ras T51B rat liver epithelial cells stsl+ gene in, 3, 263-273 transformed mouse mammary gap junction communication disruption 6-Thioguanine epithelial cells, 4, 849-858 in, epidermal growth factor in, 3, nerve growth factor activity effects of, 3, Syndecan 4 heparan sulfate proteoglycan 865-874 363-371 in focal adhesion, 5, 183-192 T-cell antigen receptor in protein kinase activity inhibition, nerve Synexin proteolysis of, 1, 907-919 growth factor receptor and, 4, 71-78 characterization of, 1, 168 tcp genes Thiolase Synoviocytes mutations of, in Saccharomyces cerevisiae, biogenesis of, in yeasts, 4, 1351-1359 collagenase gene expression in, 1, 269- 5, 1065-1080 three rows gene 278 TDH genes of Drosophila melanogaster, 4, 1161-1174 SY5Y neuroblastoma cells in yeast microtubule-associated protein Threonine kinases retinoic acid differentiation of, integrin synthesis, 3, 29-47 activation of, molecular signal integration expression and, 2, 1021-1033 Tenascin in, 3, 583-592

Vol. 5, December 1994 1403 Subject Index

Thrombin on lampbrush chromosome loops, small age-related dysfunction of, 4, 315- in diacylglycerol production, 2, 311-316 nuclear RNA effects on, 3, 249-261 322 in DNA synthesis, 1, 445-451 in Saccharomyces cerevisiae, FUS3 receptor binding to, 1, 197-213 in mitogen-activated protein kinase mediation of, 4, 107-120 Transforming growth factor-,B1 activation, 2, 675-684, 3, 63-71 TREF proteins effects on, 1, 151-164 in infarcted rat heart, 2, 241-249 mitogenic activity of, mechanism of, 3, Transcription factor(s) in mitochondria, murine, 2, 467-477 95-102 liver, fetal vs. adult, 4, 59-69, mcml-l in p34"C2 inhibition, 3, 655-665 mitogenic signaling pathway of, 1, 747- gene as, 3, 971-980 precursor of, cation-independent 761 regulation of, signal transduction mannose 6-phosphate receptor/ in platelet granule secretion, 1, 1027- pathway for, 4, 767-771 insulin-like growth factor II 1041 retinoblastoma-related protein binding to, Transforming growth factor-,82 as vascular smooth muscle cell mitogen, 4, 389-396 retinoic acid induction of, 1, 87-97 1, 453-463 of Xenopus, characterization of, 5, 1081- Transgenic mouse Thrombin-cleavage site 1092 full-length dystrophin expression in, in osteopontin, adhesive properties and, Transcription factor growth hormone normal calcium regulation in, 5, 5, 565-574 in cAMP synthesis, 3, 123-128 1159-1167 Thrombospondin Transcriptional attenuation Trans-Golgi network in endothelin-specific transcript in eukaryotic gene expression, 4, 661-668 proteins of, recycling with cell surface, 4, induction, 1, 649-659 Transcriptional enhancer 93-105 transforming growth factor-beta in ,B-casein gene expression, 3, 699-709 TGN38 protein recycling in, 5, 1093- complexes with, 3, 181-188 Transferrin receptor 1103 Thrombospondin-1 characterization of, 1, 369-377 Translation adhesive interactions with skeletal promoter for, protein binding to, 1, 151- of COX2 gene mRNA, 4, 1327-1335 myoblasts, 5, 423-437 164 Translational regulation in meiosis Thymosinf4 recruitment for endocytosis, 4, 715-727 cell-free translation system for, 1, 1057- in actin nucleotide exchange, 3, 1015- trafficking of, endosome acidification and, 1067 1024 4, 1251-1266 Translocation Thyroid cells Transformed cells of membrane proteins, sec genes in, 3, G protein oncogenes and, 3, 123-128 small nuclear ribonucleoprotein particle 129-142 Thyroid hormone receptors localization in, 3, 555-569 of polypeptides, across endoplasmic isoforms of, regulatory functions of, 2, Transforming growth factor(s), gro gene reticulum membrane, in yeast, 4, 565-574 expression stimulation by, 2, 739- 931-939 keratin gene transcription and, 1, 965- 752, myc-transformed mouse of proteins 973 mammary epithelial cells response across endoplasmic reticulum TIS genes to, 1, 864-872 membrane, 2, 851-859, 4, 919-930 expression of, nerve growth factor effects in vascular smooth muscle cell interactions of Kar2 protein and SEC63 on, 3, 363-371 stimulation, 1, 821-831 protein in, 4, 1145-1159 Tissue plasminogen activator Transforming growth factor-a Transmembrane anchors on melanoma cell surfaces, 1, 895-905 in cell motility, 1, 1003-1014 of T-cell antigen receptor, proteolysis TORI and TOR2 genes extracellular regulation of, 3, 1057-1065 and, 1, 907-919 of Saccharomyce cerevisiae, intracellular routing of, 2, 599-612 Transmembrane proteins characterization of, 5, 105-118 in keratinocyte proliferation, 2, 613-625 c-kit ligand as, 3, 349-362 Tosyl-lysine chloromethyl ketone neuronal effects of, 1, 511-521 Transthyretin gene as protease inhibitor, in T-cell receptor oligonucleotides of, in inhibition of RNA polymerase mapping on, 3, 1085- chain degradation studies, 2, 753- carcinoma cell proliferation, 3, 1235- 1094 765 1243 Transverse tubules Tosyl-phenylalanine chloromethyl ketone Transforming growth factor-# junction with sarcoplasmic reticulum, as protease inhibitor, in T-cell receptor action of, on spontaneously immortalized organization of, in excitation- chain degradation studies, 2, 753- keratinocytes, 4, 185-194 contraction coupling, 5, 1105-1118 765 in activation of connective tissue growth TREF proteins Toxin factor gene, 4, 637-645 binding to transferring receptor gene, 1, anthrax, effects on J774 macrophage-like biochemistry of, 1, 875-882 151-164 cells, 3, 1269-1277 in endothelin-specific transcript Triamcinolone acetonide TPEN (N,N,N'N'-tetrakis(2- induction, 1, 649-659 glucocorticoid receptor binding of, 3, pyridylmethyl)ethy- in epidermal growth/differentiation, 1, 1245-1257 lenediamine) 791-809 Trifluoperazine in actin reorganization modulation, 2, isoforms of, in rat liver regeneration, 2, in calcium influx to T lymphocytes, 4, 1067-1079 535-548 173-184 TPM1 gene in myocyte growth modulation, 2, 1081- Triiodothyronine in yeast, null mutation of, 4, 459-468 1095 thyroid hormone receptor activity and, 2, tra-2 gene receptors for, in choriocarcinoma cells, 3, 565-574 in Caenorhabditis elegans sex 1295-1307 Triton X-100 determination, 3, 461-473 signal transducing mechanisms of, 4, in NIH-3T3 cell disruption, mitogen- Transcription 135-144 activated protein kinase pathway cessation of, in spermatogenesis, 5, 1341- thrombospondin complexes with, 3, 181- activation in, 4, 483-493 1352 188 trk proto-oncogene in collagen genes, 1, 487-498 in urokinase-type plasminogen activator nerve growth factor receptors and, 2, of connexin43, cAMP regulation of, 3, expression, 2, 285-297 685-690 839-850 vascular smooth muscle cells response to, trkA gene

1404 Molecular Biology of the Cell Subject Index

melanoma invasiveness and, 4, 1205- regulation of, in lipopolysaccharide growth factor receptor 1216 stimulation, 3, 451-460 desensitization in, 4, 737-746 TrkA receptor Tumor necrosis factor-a in signal transduction, isoprenoid in nerve growth factor binding, 5, 549- extracellular regulation of, 3, 1057-1065 pathway activity and, 2, 627-640 563 in myocyte growth modulation, 2, 1081- Tyrosine phosphorylation Trophoblast cells 1095 in extracellular signal-regulated kinases, merosin in, 1, 731-740 signal transducing mechanisms of, 4, 2, 357-371 plasminogen activator degradation in, 1, 135-144 in interleukin-2 receptors, 2, 73-85 1043-1056 in urokinase-type plasminogen activator in microtubule-associated protein kinase, transforming growth factor receptors on, expression, 2, 285-297 2, 663-673 3, 1295-1307 Tumor promoters in mitogen-activated protein kinase, 2, Tropomyosin in collagenase gene expression, 1, 269- 675-684 in yeast, gene for, null mutation in, 4, 278 in phospholipase C.,, 2, 641-649 459-468 in talin phosphorylation, 1, 227-236 in platelet-derived growth factor receptor, Troponin C Tumor viruses, DNA 2, 413-425, 2, 651-661 calcium affinity of, 1, 166 protein phosphatases alterations by, 2, in protein (120-kDa), fibronectin/integrin identification of, 1, 165 589-598 interaction in, 2, 951-964 TRPM-2 gene in Rous sarcoma virus-modified chick in programmed cell death, 4, 953-961 Tumorigenesis lens cells, 2, 105-120 Trypanosoma brucei glycosomes basic fibroblast growth factor in, 2, 709- Tyrphostins luciferase import into, 3, 749-759 718 in signal transduction, 2, 627-640 tsBN2 cells in cells transfected with high molecular chromosome condensation in, 3, 1373- weight basic fibroblast growth factor, 1388 2, 699-708 d-Tubocurarine urokinase-type plasminogen activator in, AMP 13-25 2, 793-803, Wnt gene family in, 4, cyclic production and, 2, 1267-1275 U118 MG cells Tubular epithelial cells in RAP gene studies, 1, 764-769 angiotensin II-treated, collagen secretion Tunicamycin from, 2, 219-227 effects on epidermal growth factor- U3 snRNA-containing bodies Tubulin(s) receptor, 1, 173-188 in nucleologenesis, 5, 955-966 assembly of Tyrophostin Ultraviolet radiation GTP hydrolysis in, 3, 1155-1167 in endothelial cell migration inhibition, 5, of lymphocytes, phosphorylation in, 4, microtubule-associated tau protein in, 349-361 523-530, mcml-11OL gene sensitivity 3, 1141-1154 Tyrosine to, 3, 971-980 vs. dynamin, 3, 1181-1194 in transferrin receptor, 1, 369-377 Umbilical vein endothelial cells of erythrocyte marginal bands, dynamics Tyrosine binding sites G1 protein in, a subunit(s) of, subcellular of, 4, 323-335 on platelet-derived growth factor distribution of, 2, 1097-1113 isotypes of, functional significance of, 4, receptor, phospholipase C*gammal injury of, tyrosine phosphorylation in, 5, 445-457 binding to, 4, 49-57 349-361 in mitotic spindle formation, 3, 1259- Tyrosine kinase(s) U251MG cell line 1267 activated neu receptor of, in platelet- collagen binding to, NG2 proteoglycan monomer of, in hepatocytes, extracellular derived growth factor receptor and, 4, 1097-1108 matrix control of, 5, 1277-1280 down-regulation, 2, 651-661 Undergraduate Biology Research Program polyglutamylation of, in neurons, 4, 615- activation of, molecular signal integration University of Arizona, 5, 129-134 626 in, 3, 583-592 University education in Saccharomyces cerevisiae mating activity of, macrophage colony- undergraduate, improvement of, 5, 129- projection formation, 3, 429-444 stimulating factor regulation of, 5, 134 in yeast-microtubule-associated protein 81-95 University of Arizona identification, 3, 29-47 at adherens-type junctions, 2, 105-120 Undergraduate Biology Research ,B-Tubulin gene in B-cell antigen receptor stimulation, 2, Program, 5, 129-134 of yeasts, mutational analysis of, 5, 29-43 979-987 Tumor(s) of EpH family, in chicken embryo, 2, Untranslated region angiogenesis in, epidermal growth factor 523-534 nonhomologous, in transforming growth stimulation of, 4, 121-133 in epidermal growth factor factor-# mRNA, 2, 241-249 invasion of, transforming growth factor-a intemalization, 4, 715-727 Urokinase in, 2, 613-625 epidermal growth factor-receptor and, 1, on melanoma cell surfaces, 1, 895-905 Tumor antigens 173-188 Urokinase-type plasminogen activator in oncogenic virus cell transformation, 2, in gap junction protein communication expression of 589-598 inhibition, 1, 989-1002 in protein kinase C overexpression, 2, Tumor cells inhibitors in embryonic heart 491-502 adhesion to endothelium development, 301-313 in teratocarcinoma cells, factors arachidonic acid metabolites and, 2, in insulin receptors, lipid effects on, 2, affecting, 2, 285-297 1045-1055 65-72 in extracellular matrix degradation, 2, integrins in, 2, 347-355 as nerve growth factor receptor, 2, 685- 793-803 vascular permeability factor expression 690 inhibitors of, 1, 1043-1056 in, 3, 211-220 phosphorylation of, in melanocyte in leukemia cells, a2-macroglobulin Tumor necrosis factor(s) proliferation, c-kit proto-oncogene effects on, 2, 1057-1065 endothelial cell activation by, tumor cell role in, 3, 197-209 Uvomorulin (E-cadherin) adhesion and, 2, 347-355 receptors for, in PC 12 cells, epidermal in cell adhesion, 1, 37-44

Vol. 5, December 1994 1405 Subject Index

Vacuolar protein sorting mutants cytosolic ADP-ribosylation factors in, 5, in calcium influx to T lymphocytes, 4, in Saccharomyces cerevisiae, 3, DecG 237-252 173-184 Vacuolar proteins in Schizosaccharomyces pombe, W256 carcinosarcoma cells sorting of, in yeast, 3, 415-427 mammalian protein kinase C adhesion to endothelium, arachidonic Vacuole isotypes and, 5, 907-920 acid metabolites and, 2, 1045-1055 transport to, in yeast Kex2 protease fusion of, guanosine 5'-(3-O- Walker carcinosarcoma cells mutation, 3, 1353-1371 thio)triphosphate in, 1, 113-124 adhesion to endothelium, arachidonic VAMP protein intracellular, localization of, rab proteins acid metabolites and, 2, 1045-1055 in secretory vesicles, rab proteins effects in, 4, 747-756 weel kinase on, 4, 747-756 Vesicular stomatitis virus glycoprotein, in cdc2 phosphorylation,-5, 273-282 Vanadate transport of WEHI-3 cells brain calcium uptake and, 1, 781-790 microtubule perturbation in, 1, 921-936 proliferation of, immunophilin ligands insulin-like effects of, in Xenopus laevis during mitosis, 1, 415-424 effects on, 3, 981-987 oocytes, 2, 317-327 Villi Weibel-Palade bodies mitogenic signaling pathways of, 1, 747- epithelial lining of, tenascin variants selectin storage in, 4, 791-801 761 under, 2, 927-938 Wheat germ agglutinin in signal transduction, 2, 627-640 Vimentin production in a(1,3)fucosyltransferase studies, 2, Vascular cell adhesion molecule-i transforming growth factor in, 1, 1003- 989-1000 endothelial cell activation by, tumor cell 1014 Whey acidic protein gene expression adhesion and, 2, 347-355 Vinculin regulatory mechanisms for, 1, 45-54 Vascular endothelial cells and endothelium gene expression, serum-growth factor White spotting loci injury of, tyrosine phosphorylation in, 5, stimulation of, 1, 621-636 of c-kit ligand, 3, 349-362 349-361 phosphorylation of, phorbol ester and, 1, WISH cells integrin expression in, basic fibroblast 227-236 interferon-induced gene expression of, growth factor modulation of, 4, 973- Vinculin modulation down regulation of, 1, 707-713 982 in Rous sarcoma virus-modified chick Wnt gene family tumor cell adhesion to, 2, 347-355 lens cells, 2, 105-120 associations with cell surface, 4, 1267- Vascular endothelial growth factor Viruses 1275 isoforms of, 4, 1267-1275 envelope protein maturation in, Wnt-1 proto-oncogene stimulation of, in glioblastoma glucocorticoids and, 1, 531-541 characterization of, 3, 532-533 multiforme, 4, 121-133 gene expression in, transcriptional Wolman disease Vascular permeability factor (vascular attenuation in, 4, 661-668 cholesteryl ester metabolism in, 1, 661- endothelial growth factor) glycoproteins of, transport of, 1, 415-424, 674 expression of, in various cell types, 3, 1, 921-936 Wound healing 211-220 oncogenic, protein phosphatases connective tissue growth factor gene Vascular smooth muscle cells alterations by, 2, 589-598 expression in, 4, 637-645 endothelin stimulation of, 1, 649-659 Vitronectin fibroblast collagen receptors and, 2, growth factor stimulation of, 1, 821-831 endothelial cell adhesion to, basic 1035-1044 heparin effects on gene expression in, 1, fibroblast growth factor effects on, 4, Wound-factor-induced expression 435-443 973-982 of chicken gro gene, 2, 739-752 thrombin mitogenic effects on, 1, 453- mRNA for, expression of, transforming Xenopus 463 growth factor-,B effects on, 2, 535- cdc25 phosphatase of, phosphorylation Vasoactive hormones 548 oscillations in, 3, 927-939 in endothelin-specific transcript receptors of, on fibroblasts, 2, 1035-1044 DP proteins of, characterization of, 5, induction, 1, 649-659 Vma2l membrane protein 1081-1092 Vasoactive intestinal peptide in Saccharomyces cerevisiae, in hydrogen egg extract of cyclic AMP production and, 2, 13-25 ion-ATPase complex assembly, 5, cdc2 kinase inhibition in, 5, 323-338 Vasopressin 1039-1050 cdc2 phosphorylation in, 5, 273-282 in calcium signal coordination, 3, 113- vps35 gene coiled body assesmbly in, 5, 633-644 121 in vacuolar protein sorting defect, 3, 415- cyclin B2 of, cell cycle-regulated effects on cellular calcium responses, 1, 427 degradation of, 5, 713-724 75-86 v-scr gene expression maturation-promoting factor in, MPM- fibroblast stimulation with, 2, 229-239 in gap junction protein communication 2 antigen activation of, 5, 135-145 in vascular smooth muscle cell inhibition, 1, 989-1002 microtubule flux independence studies stimulation, 1, 821-831 v-Src protein in, 5, 217-226 activity of, characterization of, 5, 1177- eggs of Vasospasm 1184 activation of, calcium ion increase in, 1, endothelin in, 649-659 interaction with focal adhesion kinase, 5, 315-326 VCAM-1 (vascular cell adhesion molecule- 413-421 cell cycle of, p34CdC2 regulation in, 5, 1) in Saccharomyces cerevisiae growth 989-1001 endothelial cell activation by, tumor cell inhibition, 5, 283-296 cyclin A in, 3, 1279-1294 adhesion and, 2, 347-355 Vulval development fertilization of, inositol 1,4,5- Verapamil in Caenorhabditis elegans, negative trisphosphate mass changes in, 4, brain calcium uptake and, 1, 781-790 regulators of, 5, 395-412 435-443 Vesicles protein kinase activation in, protein budding of, in endoplasmic reticulum, phosphatases in, 4, 397-411 promotion of, 3, 667-676 embryonic cell cycle of, protein endosomal, fusion of, N-ethylmaleimide W-7 phosphatase 1 regulation of, 3, 687- inhibition of, 5, 773-783 in amphibian egg activation, 1, 315-326 698 formation of W-7 (calmodulin inhibitor) mitogen-activated protein kinases of

1406 Molecular Biology of the Cell Subject Index

in c-jun DNA binding inhibition in, 3, endoplasmic reticulum of protein kinase conservation in, 4, 107- 1117-1130 interactions of Kar2 protein and SEC63 120 oocytes of protein in, 4, 1145-1159 SRM1 protein of, vs. human RCC1 calcium oscillations in, inositol polypeptide translocation into, 4, 931- protein, 2, 781-792, TORI and TOR2 trisphosphate analogues in, 1, 675- 939 genes of, characterization of, 5, 105- 681 protein translocation into, 4, 919-930 118 cdc25 protein phosphorylation site fission. See Schizosaccharomyces pombe ,B-tubulin gene of, mutational analysis of, elimination in, 4, 1337-1350 geranylgeranyltransferase I defect in, 5, 29-43 connexin expression in, 4, 7-20 GTPase prenylation and, 4, 1017- zygotes of, mitochondrial sorting patterns gap junction protein communication in, 1025 in, 4, 21-36 1, 989-1002 glucocorticoid receptor action in, 3, 1245- Yeast hydroxymethylglutaryl CoA glucose uptake in, vanadate effects on, 1257 reductase domain-histidinol 2, 317-327 Golgi apparatus of, a 1,2 dehydrogenase chimera human p80-coilin insertion into, 5, galactosyltransferase activity assembly of, sec genes in, 3, 129-142 1119-1127 localization in, 5, 519-528 Yeast microtubule-associated proteins maturation of, mutant cdc2 protein mammalian RAP gene expression in, 1, identification of, 3, 29-47 kinase in, 5, 587-596 763-769 Yersinia enterocolitica mitogen-activated protein kinase mating of invasin from, Escherichia coli transfected activation in, 4, 781-790 extracellular cues in, 5, 1169-1175 with, cellular invasive properties of, nucleolin of, in nucleic acid binding, 4, FUS3 mutations in, 5, 297-312 5, 455-464 1189-1204 mitochondria of Ymel protein in ras oncogene effects on, 1, 543-554 actin-binding activity in, 5, 807-818 in yeast mitochondrial function, 5, 899- oogenesis in, p40MO` in, 5, 921-932 function of, Ymel protein in, 5, 899- 905 p34cdc2 activating kinase from, 905 YNT1 gene phosphorylation and, 3, 13-27 nematode actin capping protein mutation of, yeast mitochondrial function expression in, 4, 907-917 and, 5, 899-905 nuclear mRNA accumulation in, Yohimbine nucleolar fragmentation in, 5, 1253- in DNA synthesis, 1, 445-451 Yeast(s). See also Saccharomyces cerevisiae; 1263 ypt2 gene Schizosaccharomyces pombe nucleoporins of, functions of, 4, 209-222 of Schizosaccharomyces pombe, in actin cytoskeleton organization in, peroxisome biogenesis in, 4, 1351-1359 exocytosis, 4, 583-592, 4, 1069-1076 GTPases in, 3, 475-479 pheromone receptors of adenylyl cyclase of, analysis of, 2, 155- endocytosis of, 4, 511-521 164 genetic analysis of, 2, 439-452 alcohol oxidase assembly in, flavin protease of, tyrosine localization signal adenine dinucleotide requirements in, disruption of, 3, 1353-1371 Zajdela hepatoma cells in, 5, 829-837 protein import into mitochondria, insulin resistance in, lipid-induced, 2, 65- budding essential inner membrane protein 72 actin structure and function in, 4, for, 5, 529-538 Zinc ion 1277-1294 protein kinases of, functional homology in actin reorganization, 2, 1067-1079 minichromosomes from, centromere of, 4, 107-120 in alkaline phosphatase release from function on, 4, 859-870 proteins of, in endoplasmic reticulum cyclic AMP-resistant osteoblasts, 2, calcium-ATPase homologue (PMR1) of, vesicle budding, 3, 667-676 889-896 localization in Golgi system, 3, 633- Ras effector functions in, RAF-1 protein sensitivity to, Schizosaccharomyces pombe 654, cedl4 of, in septum formation, kinase interference with, 5, 173-181 stsl+ gene in, 3, 263-273 4, 531-539 rasl function in, regulation of, 2, 453- Zygotes cell polarization in, extracellular cues in, 465 of Drosophila melanogaster, three rows 5, 1169-1175 signal transduction in gene in, 4, 1161-1174 cytoskeleton of, actin gene mutation in, 4, CDC gene mutation in, 1, 391-401 of yeast, mitochondrial sorting patterns 459-468 FUS3 modification of, 4, 495-5 10 in, 4, 21-36

Vol. 5, December 1994 1407 Instructions to Authors

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[. J:;` President ; INTERNATIONAL CONGRESS fUSON CELL BIOLOGY J. Michael Bishop Secretary General Bill R. Brinkley Vice Presidents Douglass J. Forbes Marc W. Kirschner George M. Langford Ira Meliman Suzanne R. Pfeffer AMERICAN SOCIETY FOR CELL Thomas D. Pollard BIOLOGY ANNUAL MEETING Janet Rossant Kai Simons December 7-11, 1996 '- San Francisco, (ulifornia, USA

Mark you calendar for the 6 International Congress on Cell Biology and the 36th American Society for Cell Biology Annual Meeting San Francisco, California, USA, December 7-11, 1 996

International Advisory Commiffee Program Committee Organizing Committee Kai Simons - Germany, Chair Mina Bissell, Chair Bill R. Brinkley, Chair Denise Barlow - Austria Richard Anderson Mina J. Bissell Carl-Henrik Heldin - Sweden Judy Campisi Don W. Cleveland Colin Hopkins - United Kingdom Douglass Forbes George M. Langford David James - Australia Elaine Fuchs Elizabeth Marincola Daniel Louvard - France Michael Gottesman Suzanne R. Pfeffer Jacopo Meldolesi - Italy Richard Hynes Ira Mellman Mary Osborn - Germany Joshua Sanes Andrew W. Murray Gottfried Schatz - Switzerland Peter Walter James H. Wyche Yoshimi Takai - Japan Zena Werb

Local Arrangements Committee Andrew Murray, Chair Chris Field Tim Mitchison Frances Brodsky Susan Gasser Michel Phillipe Caroline Damsky Tim Hunt Ron Vale Heather Deacon Lena Hwang Jim Wilhelm Rick Derynck Mike Ignatius Mitsuhiro Yanagida

Call for Abstracts will be mailed in April, 1996 to all attendees of the ASCB 34th Annual Meeting. Contact the Congress Secretariat for meeting information.

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Volume 5 Issue 12 December 1994

Essay Why Should Stationary Plant Cells Have Such Dynamic Microtubules? C. Lloyd ...... 1277-1280 Articles Extracellular Matrix Controls Tubulin Monomer Levels in Hepatocytes by Regulating Protein Turnover D.J. Mooney, L.K. Hansen, R. Langer, J.P. Vacanti, and D.E. Ingber ...... 1281-1288 Organization of Small Nucleolar Ribonucleoproteins (snoRNPs) by Fluorescence In Situ Hybridization and Immunocytochemistry A.G. Matera, K.T. Tycowski, J.A. Steitz, and D.C. Ward ...... 1289-1299 f,-Centractin: Characterization and Distribution of a New Member of the Centractin Family of Actin-related Proteins S.W. Clark, 0. Staub, I.B. Clark, E.L.F. Holzbaur, B.M. Paschal, R.B. Vallee, and D.I. Meyer ...... 1301-1310 The Differential Effects of Dithiothreitol and 2-Mercaptoethanol on the Secretion of Partially and Completely Assembled Immunoglobulins Suggest that Thiol-mediated Retention Does Not Take Place in or Beyond the Golgi C. Valetti and R. Sitia ...... 1311-1324 Analysis of Transport and Targeting of Syndecan-1: Effect of Cytoplasmic Tail Deletions H.M. Miettinen, S.N. Edwards, and M. Jalkanen ...... 1325-1339 Splicing Components Are Excluded from the Transcriptionally Inactive XY Body in Male Meiotic Nuclei C. Richler, G. Ast, R. Goitein, J. Wahrman, R. Sperling, and J. Sperling ...... 1341-1352 Author Index ...... 1353-1362 Subject Index ...... 1363-1407

Cover Sixty years ago the German cytologist E. Heitz introduced the terms heterochromatin and euchromatin to distinguish parts of chromosomes that remain condensed throughout the cell cycle from those that undergo the usual cycle of condensation at mitosis and decondensation during interphase. Studies by Heitz and others on Drosophila were particularly helpful in defining the genetic properties of heterochromatin. The upper left photo on the cover shows a prophase of D. melanogaster in which each chromosome except the Y contains a large block of heterochromatin surrounding the centromere. The Y consists entirely of heterochromatin. Homologous regions of the euchromatin in the two longest chromosomes are paired, a peculiarity of the Diptera. The chromosomes of D. virilis in the upper right photo have a large block of heterochromatin next to the terminal centromere and a distal euchromatic segment. In this metaphase configuration the euchromatin and heterochromatin are both condensed but can be distinguished by the separated sister chromatids in the euchromatin. Genetic analysis of inversions and translocations showed that all but one or two of the known genes were in the euchromatin, and that large parts of the heterochromatin could be deleted without genetic consequences. When the polytene chromosomes were rediscovered in 1933 and compared with their mitotic counterparts, the heterochromatin again stood out as unusual: the banded arms consisted entirely of euchromatin, whereas the heterochromatin from all the chromosomes was drastically reduced in amount and fused into a single region called the chromocenter. As shown for D. virilis in the bottom panelA Heitz distinguished a small, highly condensed mass of a-heterochromatin in the middle of the chromocenter from a larger, more diffuse region of ,3-heterochromatin. He believed that the a-heterochromatin corresponded to the blocks of heterochromatin on mitotic chromosomes, which had failed to replicate in step with the euchromatin during formation of the polytene condition. The nature of the f3-heterochromatin was (and still is) less certain. The molecular basis for the lack of genes in the heterochromatin remained a mystery for a number of years. The answer came eventually from in situ hybridization, which showed that the heterochromatin consists of very short DNA sequences repeated millions of times. Drosophila provides the classic example of constitutive heterochromatin, which is genetically inactive because of its non-coding DNA. By contrast, facultative heterochromatin consists of otherwise normal chromosomes or parts of chromosomes that become inactive (and condensed) at special times or in' specific tissues. The inactive X in female mammals is a well-known example of facultative heterochromatin.