DOCSLIB.ORG

A REVOLUTION in the PHYSIOLOGY of the LIVING CELL FUTURE ANNUAL MEETINGS of by Gilbert N

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

A REVOLUTION IN THE PHYSIOLOGY OF THE LIVING CELL FUTURE ANNUAL MEETINGS OF by Gilbert N. Ling Orig. Ed. 1992 404 pp. $64.50 THE AMERICAN SOCIETY FOR ISBN 0-89464-398-3 CELL BIOLOGY The essence of a major revolution in cell physiology -the first since the cell was recognized as the basic unit of life a century and a half ago - is presented and altemative theories are discussed in this text. Although the conventional mem- brane-pump theory is still being taught, a new theory of the living cell, called the association-induction hypothesis has been proposed. It has successfullywfthstood 1995 twenty-five years of worldwide testing and has already generated an enhancing DC diagnostic tool ofgreat power, magnetic resonance imaging (MRI).This volume is Washington, intended forteachers, students and researchers ofbiology and medicine. December 9-13 i't...a correct basic theory of cell physiology, besides its great intrinsic value in mankind's search forknowledge aboutourselves and the world we live in, willalso play a crucial role in the ultimate conquest of cancer, AIDS, and other incurable 1996 diseases.'-from the Introduction. ASCB Annual Meeting/ on Cell Biology t When ordering please add t".Ling turns cellphysiology upside down. He Sixth International Congress $5.00 first bookl$1.50 each ad- practicallyredefines the cell. He provides com- San Francisco, California ditional book to cover shipping pellingevidencefor headequacyofhis theoryn December 7-11 charges. Foreign shipping costs evidence that cannot fail to impress even the available upon request. most extreme skeptics....'- Gerald H. Pollock, _ Ph.D., Univ. ofWashington. Please call or write for our Free Biology catalog 1997 KRIEGER PUBLISHING COMPANY Washington, DC OP. Box 9542 ' Melbourne, FL32902-9542 December 13-17 (407) 724-9542 ' Order Dept. (407) 727-7270 2 \/ ~~~FAX(407)951-3671 + Statement of Ownership, Management and Circulation (Required by 39 U. S C. 3685) 1A lleo P,lbl--tro I PUBLICATION NO Grl .'AlP rilin,g M1,,lcI. lar Aiolo9y ,f th Ce.l'r,1l 0 Ii| 4 1 11/1/94 3Feeni Iss- 3A N. ra P,t,,,Ih.d 3B | ks--e A-1-1llSbctir Pr-c A--nvIa,y Mb6 r Sf3No$10 1 $150 Mo.,t8UIy 12 - iist1 $300 Stud 140 NO MORE RABBIT WRANGLING ASnCI, 965,))l1ockwil1, P6ik^, 111.61111111, ML) 20814-3112 Sam,e_.11~1 a:;_BI t:er_._4...4 2 _ ,11.,__.,II20. .65)0. _ _ _.1 1,. ._ 6 F.11 Nia-re -ld PoiPlt A.rilrq Add-lRres 0r FVA1h,15t. fd-IIrr. -dle M.-,,y Ul Fd,tear iTh.l r .1 .7hJ1 ln^ ASCBII 9461 R88ck6ill) [like, B11tl)S,la, MD 20814-1912 Dla,,vid6 RII1t911t1e8iAS C6B 0 Roc8k16vi Iiko B1t. 151s,la1 M4D 208I14-3992 Ma ag,nq Ed-orlN......i./Jr...IB /rAhfrJS,rt.il,' R5a1 IIha KaAA,ABmaAASiBR, LA1651 Rltykv.i1j1ePiike1Bet.11,21BH2I1--3932BBI ~~~~~~~~~F.....N..... C..p__Fl.gNl.sCrnlMaIlingAdd,... The AmL.Li=:ai SQLcieLy fur .Cclll Tiolocy... ... 9651} RoDckville Pike, Bethesda MD 2s1Si4-3992 41.B.,.......11B d I,I Il 11B11p11*BB,.) ...... Ad'. K r,-,,B.'1111.1. B,.. _11g.,;-..J..,0B1-B_ 1r..M1- .I -i__B_..$M-BBB H OB1..1.. A_..._ T.W Secrre rOf h,tesr rtrr rr A11oilPh."":1 - CC'T1994 F.11 Nnm....C-mpllw. M.i0lng Add,... .1B1 _ 21111,1 14 _____......._.__..._. ANIMAL PHARM SERVICES 9 F B,C BmBleBo-b N.-,p,o 0rg-B 1i,-i-rs.A -BiBBdT.11Aa BtSpIBR.t.s SBBrBB4B12BIBB)B 111: B TheF1dC f-- 8 1.d B IN, .,Id lh. W26622100Mr I ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~. * r l-n - r n ,c. H.. N., Ch.ar,g,d O u r n g (:l1-,rg.J D,-rarg 1/f I-hrJnr0eI ......he...J "PW-evptafiterrJ P.B..B PrBdB, 2 11,Pr-d,rBdIB1 BBr1-.BIBIB1IBBIBB12 M- 11Ih- - - *n EXl rulad N-llr. 1,f (:tllAerl.g. Ne C..,i.. E.r.h I-.v Ouring Acr-I N.D C.pi.. Single I.... We will supply you with high quality polyclonal -Weeri4e.r, el,f ,11r eeel 17 Moral.hs PLbh.hhed N--es 10 Filing D... A ta N,, P-,le(N,R.rPrl Vr 2&fi2 210{} antibodies. We use specific pathogen free BIPard *nd:o,rRqeed.. C,.d aio 1. SleI.. ue -.1er*n 1er1-eedor *nd onesle .. _ _.___ ._ . ____ _ _ 2 NI. Sb ,rP,,-n animals. Rabbits, guinea pigs and goats are 1324 $409 C T.Wa Ps,d -dWe, R.,,...(.d lesto immediately available. Other animals by special IS1u90J1-11 111121 13 24 1409 O. T".. Dwlsrb.t-n by M.ti1. C-4,ie or Olh., hl-an order. Best Prices. Best Service. Best Animals. B.116B.1C1111p,I-V.11.1dO1b., F-ree C.p-B 4 .3_ 158 E rOl1w 1,D 8rb-- Bn d101 1777 1 559 . For complete pricing and availability call: F. C.p..s NolDsrbue Off .1P.o.ve- - -d111BIBB-d.1 ., R885 5_4$ 2. Relurr f-o N.,- Ag.nts 0} 1 B 6I G '.TOTAL S111B1 F. Fl -d2 -1I118$Bld9-1- p1-1B B1r4A 2662 21.00 11 5~~~~~~~~~~~~~~~~-g.--Jr-rd T,tI. ,f Fd,M,t. Pu,ble"r B...... M@ne-go- O ne cBrtify that the statemIiBts made bY B- 7 BB g110BB USDA-NIH assurances "GLP' available me abo,ve aB corBect Bnd complete ,4112ZJ9%raB.I'-11. 9"wY-t PS FB.- 3526.____199BBB_.....~~~~~~... /Srr r. Molecular Biology * 0* ¢* O* ** 0 4p 0 of the Cell 0f* .t 4 Editor-in-Chief Editor David Botstein Keith R. Yamamoto Stanford University School of Medicine University of California, San Francisco Associate Editors J. Michael Bishop Carl-Henrik Heldin Erkki Ruoslahti University of California, San Francisco Ludwig Institute for Cancer Research, La Jolla Cancer Research Foundation Elizabeth H. Blackburn Uppsala, Sweden Gottfned Schatz University of California, San Francisco Kenneth Holmes University of Basel, Switzerland Michael S. Brown Max-Planck-Institut fur Medizinische Randy W. Schekman University of Texas Southwestern Forschung, Heidelberg, Germany University of California, Berkeley Medical Center, Dallas Tim Hunt Joseph Schlessinger Gerald R. Fink ICRF Clare Hall Labs, United Kingdom New York University Medical Center Whitehead Institute, Cambridge Richard Hynes Lucy Shapiro Joseph Gall Massachusetts Institute of Technology, Stanford University School of Medicine Carnegie Institution, Baltimore Cambridge Judith Kimble Timothy A. Springer Mary-Jane Gething University of Wisconsin, Madison Center for Blood Research, Boston University of Texas Southwestern James A. Spudich Medical Center, Dallas Marc W. Kirschner Harvard Medical School, Boston Stanford University School of Medicine Alfred G. Gilman Masatoshi University of Texas Southwestern Timothy J. Mitchison Takeichi Medical Center, Dallas University of California, San Francisco Kyoto University, Japan Roger Y. Tsien Joseph L. Goldstein Elliot Meyerowitz San University of Texas Southwestern California Institute of Technology, Pasadena Universityk of California, Diego Michael H. Medical Center, Dallas Thomas D. Pollard Wigler Guido Guidotti Johns Hopkins University, Baltimore Cold Spring Harbor Laboratory Harvard University, Cambridge Mitsuhiro Yanagida Martin Raff Kyoto University, Japan Leland Hartwell University College London, United Kingdom University of Washington, Seattle Joan Ruderman Harvard Medical School, Boston Essay Editors Art & History Editor Managing Editor Bruce M. Alberts Joseph Gall Rosalba A. Kampman University of California, San Francisco Carnegie Institution, Baltimore The American Society for Cell Biology, Henry R. Bourne Bethesda University of California, San Francisco Editorial Board Ken-Ichi Arai James R. Feramisco Chris Kaiser Gerald M. Rubin William Balch Douglass J. Forbes Mary B. Kennedy Melvin Simon Mary Beckerle Thomas D. Fox Michael Klagsbrun William S. Sly Merton Bemfield Margaret T. Fuller Stuart Komfeld Solomon H. Snyder Michael Berridge Michael M. Gottesman Robert J. Lefkowitz Paul W. Steinberg Melanie Cobb Dan Gottschling Marc Mumby Antti Vaheri Gerald Crabtree Warner Greene Paul Nurse Denisa Wagner Tom Curran Ed Harlow Bjorn Olsen Peter Walter Benoit de Crombrugghe Tony Hunter Suzanne R. Pfeffer Paul M. Wassarman Gregor Eichele Rudolf Jaenisch Steven I. Reed Tadashi Yamamoto Marilyn Farquhar Elizabeth Jones Publication Staff Kevin Flynn Kathryn King Georgia Monitor Edward Newman Editorial Assistant Production Manager Subscriptions Advertising Owned and pubLished by The American Society for Cell Biology, Elizabeth Marincola, Executive Director Cover Sixty years ago the German cytologist E. Heitz introduced the terms heterochromatin and euchromatin to distinguish parts of chromosomes that remain condensed throughout the cell cycle from those that undergo the usual cycle of condensation at mitosis and decondensation during interphase. Studies by Heitz and others on Drosophila were particularly helpful in defining the genetic properties of heterochromatin. The upper left photo on the cover shows a prophase of D. melanogaster in which each chromosome except the Y contains a large block of heterochromatin surrounding the centromere. The Y consists entirely of heterochromatin. Homologous regions of the euchromatin in the two longest chromosomes are paired, a peculiarity of the Diptera. The chromosomes of D. virilis in the upper right photo have a large block of heterochromatin next to the terminal centromere and a distal euchromatic segment. In this metaphase configuration the euchromatin and heterochromatin are both condensed but can be distinguished by the separated sister chromatids in the euchromatin. Genetic analysis of inversions and translocations showed that all but one or two of the known genes were in the euchromatin, and that large parts of the heterochromatin could be deleted without genetic consequences. When the polytene chromosomes were rediscovered in 1933 and compared with their mitotic counterparts, the heterochromatin again stood out as unusual: the banded arms consisted entirely of euchromatin, whereas the heterochromatin from all the chromosomes was drastically reduced in amount and fused into a single region called the chromocenter. As shown for D.
Recommended publications
  • Characterisation of the Α1b-Adrenoceptor by Modeling, Dynamics and Virtual Screening Kapil Jain B.Pharm, M.S.(Pharm.)

    Characterisation of the Α1b-Adrenoceptor by Modeling, Dynamics and Virtual Screening Kapil Jain B.Pharm, M.S.(Pharm.)

    Characterisation of the α1B-Adrenoceptor by Modeling, Dynamics and Virtual Screening Kapil Jain B.Pharm, M.S.(Pharm.) A Thesis submitted for the degree of Master of Philosophy at The University of Queensland in 2018 Institute for Molecular Bioscience 0 Abstract G protein-coupled receptors (GPCRs) are the largest druggable class of proteins yet relatively little is known about the mechanism by which agonist binding induces the conformational changes necessary for G protein activation and intracellular signaling. Recently, the Kobilka group has shown that agonists, neutral antagonists and inverse agonists stabilise distinct extracellular surface (ECS) conformations of the β2-adrenergic receptor (AR) opening up new possibilities for allosteric drug targeting at GPCRs. The goal of this project is to extend these studies to define how the ECS conformation of the α1B-AR changes during agonist binding and develop an understanding of ligand entry and exit mechanisms that may help in the design of specific ligands with higher selectivity, efficacy and longer duration of action. Two parallel approaches were initiated to identify likely functional residues. The role of residues lining the primary binding site were predicted by online web server (Q-Site Finder) while secondary binding sites residues were predicted from molecular dynamics (MD) simulations. Predicted functionally significant residues were mutated and their function was established using FLIPR, radioligand and saturation binding assays. Despite the α1B-AR being pursued as a drug target for over last few decades, few specific agonists and antagonists are known to date. In an attempt to address this gap, we pursued ligand-based approach to find potential new leads.
  • Computational Methods for Prediction and Classification of G Protein-Coupled Receptors Khodeza Begum University of Texas at El Paso, Kbegum@Miners.Utep.Edu

    Computational Methods for Prediction and Classification of G Protein-Coupled Receptors Khodeza Begum University of Texas at El Paso, [email protected]

    University of Texas at El Paso DigitalCommons@UTEP Open Access Theses & Dissertations 2017-01-01 Computational methods for prediction and classification of G protein-coupled receptors Khodeza Begum University of Texas at El Paso, [email protected] Follow this and additional works at: https://digitalcommons.utep.edu/open_etd Part of the Bioinformatics Commons, Computer Sciences Commons, and the Mathematics Commons Recommended Citation Begum, Khodeza, "Computational methods for prediction and classification of G protein-coupled receptors" (2017). Open Access Theses & Dissertations. 408. https://digitalcommons.utep.edu/open_etd/408 This is brought to you for free and open access by DigitalCommons@UTEP. It has been accepted for inclusion in Open Access Theses & Dissertations by an authorized administrator of DigitalCommons@UTEP. For more information, please contact [email protected]. COMPUTATIONAL METHODS FOR PREDICTION AND CLASSIFICATION OF G PROTEIN-COUPLED RECEPTORS KHODEZA BEGUM Master’s Program in Computational Science APPROVED: Ming-Ying Leung, Ph.D., Chair Rachid Skouta, Ph.D. Xiaogang Su, Ph.D. Charlotte M. Vines, Ph.D. Charles Ambler, Ph.D. Dean of the Graduate School Copyright © by Khodeza Begum 2017 COMPUTATIONAL METHODS FOR PREDICTION AND CLASSIFICATION OF G PROTEIN-COUPLED RECEPTORS by KHODEZA BEGUM, B.S. THESIS Presented to the Faculty of the Graduate School of The University of Texas at El Paso in Partial Fulfillment of the Requirements for the Degree of MASTER OF SCIENCE COMPUTATIONAL SCIENCE PROGRAM THE UNIVERSITY OF TEXAS AT EL PASO December 2017 Acknowledgements I would first like to thank my advisor Dr. Ming-Ying Leung for the continuous support and encouragement in my study and thesis.
  • Molecular Dissection of G-Protein Coupled Receptor Signaling and Oligomerization

    Molecular Dissection of G-Protein Coupled Receptor Signaling and Oligomerization

    MOLECULAR DISSECTION OF G-PROTEIN COUPLED RECEPTOR SIGNALING AND OLIGOMERIZATION BY MICHAEL RIZZO A Dissertation Submitted to the Graduate Faculty of WAKE FOREST UNIVERSITY GRADUATE SCHOOL OF ARTS AND SCIENCES in Partial Fulfillment of the Requirements for the Degree of DOCTOR OF PHILOSOPHY Biology December, 2019 Winston-Salem, North Carolina Approved By: Erik C. Johnson, Ph.D. Advisor Wayne E. Pratt, Ph.D. Chair Pat C. Lord, Ph.D. Gloria K. Muday, Ph.D. Ke Zhang, Ph.D. ACKNOWLEDGEMENTS I would first like to thank my advisor, Dr. Erik Johnson, for his support, expertise, and leadership during my time in his lab. Without him, the work herein would not be possible. I would also like to thank the members of my committee, Dr. Gloria Muday, Dr. Ke Zhang, Dr. Wayne Pratt, and Dr. Pat Lord, for their guidance and advice that helped improve the quality of the research presented here. I would also like to thank members of the Johnson lab, both past and present, for being valuable colleagues and friends. I would especially like to thank Dr. Jason Braco, Dr. Jon Fisher, Dr. Jake Saunders, and Becky Perry, all of whom spent a great deal of time offering me advice, proofreading grants and manuscripts, and overall supporting me through the ups and downs of the research process. Finally, I would like to thank my family, both for instilling in me a passion for knowledge and education, and for their continued support. In particular, I would like to thank my wife Emerald – I am forever indebted to you for your support throughout this process, and I will never forget the sacrifices you made to help me get to where I am today.
  • Steven, Stacy (2012) the Pharmacology of the 5-HT2A Receptor and the Difficulty Surrounding Single Taret Models

    Steven, Stacy (2012) the Pharmacology of the 5-HT2A Receptor and the Difficulty Surrounding Single Taret Models

    Steven, Stacy (2012) The pharmacology of the 5-HT2A receptor and the difficulty surrounding single taret models. MSc(R) thesis. http://theses.gla.ac.uk/3636/ Copyright and moral rights for this thesis are retained by the author A copy can be downloaded for personal non-commercial research or study, without prior permission or charge This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the Author The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the Author When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given Glasgow Theses Service http://theses.gla.ac.uk/ [email protected] The pharmacology of the 5-HT2A receptor and the difficulty surrounding functional studies with single target models A thesis presented for the degree of Master of Science by research Stacy Steven April 2012 Treatment of many disorders can be frequently problematic due to the relatively non selective nature of many drugs available on the market. Symptoms can be complex and expansive, often leading to symptoms representing other disorders in addition to the primary reason for treatment. In particular mental health disorders fall prey to this situation. Targeting treatment can be difficult due to the implication of receptors in more than one disorder, and more than one receptor in a single disorder. In the instance of GPCRs, receptors such as the serotonin receptors (and in particular the 5-HT2A for the interest of this research) belong to a large family of receptors, the GPCR Class A super family.
  • Nov. Issue of ASCB Newsletter

    Nov. Issue of ASCB Newsletter

    ASCB NOVEMBER 2010 NEWSLETTER VOLUME 33, NUMBER 10 Improving Submit Images to Work–Life Satisfaction The Cell: An Image Library Page 15 Published Images and Videos Accepted To further discovery and education, the ASCB’s repository for cellular images and videos accepts Are You First published and unpublished work. According to Caroline Kane, the PI for The Cell: An Image Author or Last? Library, “This new repository of cell images is expertly reviewed and annotated to provide a valuable resource for researchers, educators, and the general public. Access to the database is Page 21 free and open. The Cell aims to advance research and, ultimately, have a positive impact upon human health and education.” The Cell’s expanded licensing options for contributors and users will promote faster growth and enhanced usefulness. The Cell is available as a repository for images in published articles Cell Biology and supplementary materials. It can also serve as an archive for additional images and movies Italian Style that helped lead to discovery. Page 23 Understanding Distribution Rights The Cell welcomes unpublished and previously published images, but contributors must have the distribution rights. Many publishers, like the ASCB, which publishes Molecular Biology of the Cell, allow authors to retain copyright. However, publishers may nevertheless limit distribution Inside of the work. Limitations may relate to intended use (commercial and/or educational), alteration, and attribution. Authors should confirm the distribution rights before selecting the appropriate Public Policy Briefing 3 option when contributing to The Cell. Contributors with appropriate distribution rights might select a public domain license. Annual Meeting Program 6 This license is appropriate for those who own copyright without limitations as well as for those Networking at Annual Meeting 11 submitting images or videos where all authors are U.S.
  • Insights Into Nuclear G-Protein-Coupled Receptors As Therapeutic Targets in Non-Communicable Diseases

    Insights Into Nuclear G-Protein-Coupled Receptors As Therapeutic Targets in Non-Communicable Diseases

    pharmaceuticals Review Insights into Nuclear G-Protein-Coupled Receptors as Therapeutic Targets in Non-Communicable Diseases Salomé Gonçalves-Monteiro 1,2, Rita Ribeiro-Oliveira 1,2, Maria Sofia Vieira-Rocha 1,2, Martin Vojtek 1,2 , Joana B. Sousa 1,2,* and Carmen Diniz 1,2,* 1 Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal; [email protected] (S.G.-M.); [email protected] (R.R.-O.); [email protected] (M.S.V.-R.); [email protected] (M.V.) 2 LAQV/REQUIMTE, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal * Correspondence: [email protected] (J.B.S.); [email protected] (C.D.) Abstract: G-protein-coupled receptors (GPCRs) comprise a large protein superfamily divided into six classes, rhodopsin-like (A), secretin receptor family (B), metabotropic glutamate (C), fungal mating pheromone receptors (D), cyclic AMP receptors (E) and frizzled (F). Until recently, GPCRs signaling was thought to emanate exclusively from the plasma membrane as a response to extracellular stimuli but several studies have challenged this view demonstrating that GPCRs can be present in intracellular localizations, including in the nuclei. A renewed interest in GPCR receptors’ superfamily emerged and intensive research occurred over recent decades, particularly regarding class A GPCRs, but some class B and C have also been explored. Nuclear GPCRs proved to be functional and capable of triggering identical and/or distinct signaling pathways associated with their counterparts on the cell surface bringing new insights into the relevance of nuclear GPCRs and highlighting the Citation: Gonçalves-Monteiro, S.; nucleus as an autonomous signaling organelle (triggered by GPCRs).
  • Biased Signaling of G Protein Coupled Receptors (Gpcrs): Molecular Determinants of GPCR/Transducer Selectivity and Therapeutic Potential

    Biased Signaling of G Protein Coupled Receptors (Gpcrs): Molecular Determinants of GPCR/Transducer Selectivity and Therapeutic Potential

    Pharmacology & Therapeutics 200 (2019) 148–178 Contents lists available at ScienceDirect Pharmacology & Therapeutics journal homepage: www.elsevier.com/locate/pharmthera Biased signaling of G protein coupled receptors (GPCRs): Molecular determinants of GPCR/transducer selectivity and therapeutic potential Mohammad Seyedabadi a,b, Mohammad Hossein Ghahremani c, Paul R. Albert d,⁎ a Department of Pharmacology, School of Medicine, Bushehr University of Medical Sciences, Iran b Education Development Center, Bushehr University of Medical Sciences, Iran c Department of Toxicology–Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Iran d Ottawa Hospital Research Institute, Neuroscience, University of Ottawa, Canada article info abstract Available online 8 May 2019 G protein coupled receptors (GPCRs) convey signals across membranes via interaction with G proteins. Origi- nally, an individual GPCR was thought to signal through one G protein family, comprising cognate G proteins Keywords: that mediate canonical receptor signaling. However, several deviations from canonical signaling pathways for GPCR GPCRs have been described. It is now clear that GPCRs can engage with multiple G proteins and the line between Gprotein cognate and non-cognate signaling is increasingly blurred. Furthermore, GPCRs couple to non-G protein trans- β-arrestin ducers, including β-arrestins or other scaffold proteins, to initiate additional signaling cascades. Selectivity Biased Signaling Receptor/transducer selectivity is dictated by agonist-induced receptor conformations as well as by collateral fac- Therapeutic Potential tors. In particular, ligands stabilize distinct receptor conformations to preferentially activate certain pathways, designated ‘biased signaling’. In this regard, receptor sequence alignment and mutagenesis have helped to iden- tify key receptor domains for receptor/transducer specificity.
  • Suffrage Science Contents

    Suffrage Science Contents

    Suffrage science Contents Introduction Brenda Maddox and Vivienne Parry on sex and success in science 3 Love Professor Sarah-Jayne Blakemore and Dr Helen Fisher on love and social cognition 6 Life Professor Liz Robertson and Dr Sohaila Rastan on developmental biology and genetics 10 Structure Professor Dame Louise Johnson and Professor Janet Thornton on structural biology 15 Strife Professors Fiona Watt and Mary Collins on cancer and AIDS 19 Suffrage Heirloom Jewellery Designs to commemorate women in science 23 Suffrage Textiles Ribbons referencing the suffrage movement 33 Index of Featured Women Scientists Pioneering female contributions to Life Science 43 Acknowledgements Contributions and partnerships 47 Tracing Suffrage Heirlooms Follow the provenance of 13 pieces of Suffrage Heirloom Jewellery 48 1 A successful career in science is always demanding of intellect “ hard work and resilience; only more so for most women. ” Professor Dame Sally C Davies From top, left to right: (Row 1) Anne McLaren, Barbara McClintock, Beatrice Hahn, Mina Bissell, Brenda Maddox, Dorothy Hodgkin, (Row 2) Brigid Hogan, Christiane Nüsslein-Volhard, Fiona Watt, Gail Martin, Helen Fisher, Françoise Barré-Sinoussi, (Row 3) Hilde Mangold, Jane Goodall, Elizabeth Blackburn, Janet Thornton, Carol Greider, Rosalind Franklin, (Row 4) Kathleen Lonsdale, Liz Robertson, Louise Johnson, Mary Lyon, Mary Collins, Vivienne Parry, (Row 5) Uta Frith, Amanda Fisher, Linda Buck, Sara-Jayne Blakemore, Sohaila Rastan, Zena Werb 2 Introduction To commemorate 100 years of International Women’s Day in 2011, Suffrage Science unites the voices of leading female life scientists Brona McVittie talks to Vivienne Parry and Brenda Maddox about sex and success in science Dorothy Hodgkin remains the only British woman to Brenda Maddox is author of The Dark Lady of DNA, have been awarded a Nobel Prize for science.
  • Biologie Moléculaire De LA CELLULE Biologie Moléculaire De Sixième Édition

    Biologie Moléculaire De LA CELLULE Biologie Moléculaire De Sixième Édition

    Sixième édition BRUCE ALEXANDER JULIAN DAVID MARTIN KEITH PETER ALBERTS JOHNSON LEWIS MORGAN RAFF ROBERTS WALTER Biologie moléculaire de LA CELLULE Biologie moléculaire de Sixième édition LA CELLULESixième édition Biologie moléculaire de moléculaire Biologie LA CELLULE LA BRUCE ALBERTS BRUCE ALBERTS ALEXANDER JOHNSON ALEXANDER JOHNSON JULIAN LEWIS JULIAN LEWIS DAVID MORGAN DAVID MORGAN MARTIN RAFF MARTIN RAFF KEITH ROBERTS KEITH ROBERTS PETER WALTER PETER WALTER -:HSMCPH=WU[\]\: editions.lavoisier.fr 978-2-257-20678-7 20678-Albers2017.indd 1-3 08/09/2017 11:09 Chez le même éditeur Culture de cellules animales, 3e édition, par G. Barlovatz-Meimon et X. Ronot Biochimie, 7e édition, par J. M. Berg, J. L. Tymoczko, L. Stryer L’essentiel de la biologie cellulaire, 3e édition, par B. Alberts, D. Bray, K. Hopkin, A. Johnson, A. J. Lewis, M. Ra", K. Roberts et P. Walter Immunologie, par L. Chatenoud et J.-F. Bach Génétique moléculaire humaine, 4e édition, par T. Strachan et A. Read Manuel de poche de biologie cellulaire, par H. Plattner et J. Hentschel Manuel de poche de microbiologie médicale, par F. H. Kayser, E. C. Böttger, P. Deplazes, O. Haller, A. Roers Atlas de poche de génétique, par E. Passarge Atlas de poche de biotechnologie et de génie génétique, par R.D. Schmid Les biosimilaires, par J.-L. Prugnaud et J.-H. Trouvin Bio-informatique moléculaire : une approche algorithmique (Coll. IRIS), par P. A. Pevzner et N. Puech Cycle cellulaire et cytométrie en "ux, par D. Grunwald, J.-F. Mayol et X. Ronot La cytométrie en "ux, par X. Ronot, D.
  • Communicating Biochemistry: Meetings and Events

    Communicating Biochemistry: Meetings and Events

    © The Authors. Volume compilation © 2011 Portland Press Limited Chapter 3 Communicating Biochemistry: Meetings and Events Ian Dransfield and Brian Beechey Scientific conferences organized by the Biochemical Society represent a key facet of activity throughout the Society’s history and remain central to the present mission of promoting the advancement of molecular biosciences. Importantly, scientific conferences are an important means of communicating research findings, establishing collaborations and, critically, a means of cementing the community of biochemical scientists together. However, in the past 25 years, we have seen major changes to the way in which science is communicated and also in the way that scientists interact and establish collabo- rations. For example, the ability to show videos, “fly through” molecular structures or show time-lapse or real-time movies of molecular events within cells has had a very positive impact on conveying difficult concepts in presentations. However, increased pressures on researchers to obtain/maintain funding can mean that there is a general reluctance to present novel, unpublished data. In addition, the development of email and electronic access to scientific journals has dramatically altered the potential for communi- cation and accessibility of information, perhaps reducing the necessity of attending meetings to make new contacts and to hear exciting new science. The Biochemical Society has responded to these challenges by progressive development of the meetings format to better match the
  • Research Organizations and Major Discoveries in Twentieth-Century Science: a Case Study of Excellence in Biomedical Research Hollingsworth, J

    Research Organizations and Major Discoveries in Twentieth-Century Science: a Case Study of Excellence in Biomedical Research Hollingsworth, J

    www.ssoar.info Research organizations and major discoveries in twentieth-century science: a case study of excellence in biomedical research Hollingsworth, J. Rogers Veröffentlichungsversion / Published Version Arbeitspapier / working paper Zur Verfügung gestellt in Kooperation mit / provided in cooperation with: SSG Sozialwissenschaften, USB Köln Empfohlene Zitierung / Suggested Citation: Hollingsworth, J. R. (2002). Research organizations and major discoveries in twentieth-century science: a case study of excellence in biomedical research. (Papers / Wissenschaftszentrum Berlin für Sozialforschung, 02-003). Berlin: Wissenschaftszentrum Berlin für Sozialforschung gGmbH. https://nbn-resolving.org/urn:nbn:de:0168-ssoar-112976 Nutzungsbedingungen: Terms of use: Dieser Text wird unter einer Deposit-Lizenz (Keine This document is made available under Deposit Licence (No Weiterverbreitung - keine Bearbeitung) zur Verfügung gestellt. Redistribution - no modifications). We grant a non-exclusive, non- Gewährt wird ein nicht exklusives, nicht übertragbares, transferable, individual and limited right to using this document. persönliches und beschränktes Recht auf Nutzung dieses This document is solely intended for your personal, non- Dokuments. Dieses Dokument ist ausschließlich für commercial use. All of the copies of this documents must retain den persönlichen, nicht-kommerziellen Gebrauch bestimmt. all copyright information and other information regarding legal Auf sämtlichen Kopien dieses Dokuments müssen alle protection. You are not allowed
  • Physiology News

    Physiology News

    PHYSIOLOGY NEWS summer 2009 I number 75 Calcium signalling insights from Sir Michael Berridge Physiology 2009 – back at UCD after an 18 year break Conference networking leads to post-doc position on a Japanese tropical island PowerLab : buy or rent Easy to use, easy to acquire PowerLab® Teaching Systems with LabTutor® and LabChart® soft ware have set the benchmarks in quality, ease-of-use, safety and fl exibility for over 20 years. Now, we’re proud to introduce another industry fi rst...the option to either buy or rent this powerful technology! Th e choice of purchase or rental options makes it even easier to get the world’s leading data acquisition system for Buy or Rent life science education. Our new Smart Rent Option off ers brand-new systems, low entry cost and free experiment soft ware upgrades. Talk to us to fi nd out more. Intuitive PowerLab Teaching Systems include experiments for human physiology, exercise physiology, pharmacology, Flexible Tool neurophysiology, psychophysiology, biology and more. Th e fl exibility of PowerLab systems adds to their cost- eff ectiveness – for purchasers and renters. Choose from over 100 experiments and 400 exercises More for introductory through to advanced levels. You can select the software for your courses and use authoring tools to modify/create experiments. Choose from over Experiments 20 Teaching Systems or let us create a customised solution. Contact us for an obligation-free demonstration. Tel: 01865 891 623 Email: [email protected] Web: www.adinstruments.com/buy_rent EQUIPMENT CERTIFIED FOR HUMAN CONNECTION UK • GERMANY • USA • BRAZIL • CHILE • INDIA • JAPAN • CHINA • MALAYSIA • NEW ZEALAND • AUSTRALIA CELEBRATING OVER 20 YEARS OF INNOVATIONS ADI_InstStudent_UK_PhysioNews.indd 1 15/5/09 2:32:20 PM PHYSIOLOGY NEWS Editorial 3 Meetings The Society’s dog.