Human Th17 Cells Share Major Trafficking Receptors with Both Polarized Effector T Cells and FOXP3+ Regulatory T Cells
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Enhanced Monocyte Migration to CXCR3 and CCR5 Chemokines in COPD
ERJ Express. Published on March 10, 2016 as doi: 10.1183/13993003.01642-2015 ORIGINAL ARTICLE IN PRESS | CORRECTED PROOF Enhanced monocyte migration to CXCR3 and CCR5 chemokines in COPD Claudia Costa1, Suzanne L. Traves1, Susan J. Tudhope1, Peter S. Fenwick1, Kylie B.R. Belchamber1, Richard E.K. Russell2, Peter J. Barnes1 and Louise E. Donnelly1 Affiliations: 1Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK. 2Chest Clinic, King Edward King VII Hospital, Windsor, UK. Correspondence: Louise E. Donnelly, Airway Disease, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK. E-mail: [email protected] ABSTRACT Chronic obstructive pulmonary disease (COPD) patients exhibit chronic inflammation, both in the lung parenchyma and the airways, which is characterised by an increased infiltration of macrophages and T-lymphocytes, particularly CD8+ cells. Both cell types can express chemokine (C-X-C motif) receptor (CXCR)3 and C-C chemokine receptor 5 and the relevant chemokines for these receptors are elevated in COPD. The aim of this study was to compare chemotactic responses of lymphocytes and monocytes of nonsmokers, smokers and COPD patients towards CXCR3 ligands and chemokine (C-C motif) ligand (CCL)5. Migration of peripheral blood mononuclear cells, monocytes and lymphocytes from nonsmokers, smokers and COPD patients toward CXCR3 chemokines and CCL5 was analysed using chemotaxis assays. There was increased migration of peripheral blood mononuclear cells from COPD patients towards all chemokines studied when compared with nonsmokers and smokers. Both lymphocytes and monocytes contributed to this enhanced response, which was not explained by increased receptor expression. -
CCR5 Deficiency Impairs CD4+ T Cell Memory Responses and Antigenic Sensitivity
bioRxiv preprint doi: https://doi.org/10.1101/2020.02.14.948893; this version posted February 14, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. CCR5 deficiency impairs CD4+ T cell memory responses and antigenic sensitivity through increased ceramide synthesis Ana Martín-Leal1§, Raquel Blanco1§, Josefina Casas2,3, María E. Sáez4, Elena Rodríguez- Bovolenta5, Itziar de Rojas6, Carina Drechsler7,8,9, Luis Miguel Real10,11, Gemma Fabrias2,3, Agustín Ruíz6,12, Mario Castro13, Wolfgang W.A. Schamel7,8,14, Balbino Alarcón5, Hisse M. van Santen5, Santos Mañes1* 1Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB/CSIC), Madrid, Spain; 2Department of Biological Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain and 3CIBER Liver and Digestive Diseases (CIBER-EDH), Instituto de Salud Carlos III, Madrid, Spain; 4Centro Andaluz de Estudios Bioinformáticos (CAEBi), Seville, Spain; 5Department of Cell Biology and Immunology, Centro de Biología Molecular Severo Ochoa (CBMSO/CSIC), Madrid, Spain; 6Alzheimer Research Center and Memory Clinic of the Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain; 7Signaling Research Centers BIOSS and CIBSS, 8Department of Immunology, Faculty of Biology and 9Institute for Pharmaceutical Sciences, University of Freiburg, Freiburg, Germany; 10Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, -
CXCR6 Within T-Helper (Th) and T-Cytotoxic
European Journal of Endocrinology (2005) 152 635–643 ISSN 0804-4643 EXPERIMENTAL STUDY CXCR6 within T-helper (Th) and T-cytotoxic (Tc) type 1 lymphocytes in Graves’ disease (GD) G Aust, M Kamprad1, P Lamesch2 and E Schmu¨cking Institute of Anatomy, 1Department of Clinical Immunology and Transfusion Medicine and 2Department of Surgery, University of Leipzig, Phillipp-Rosenthal-Str. 55, Leipzig, 04103, Germany (Correspondence should be addressed to G Aust; Email: [email protected]) Abstract Objective: In Graves’ disease (GD), stimulating anti-TSH receptor antibodies are responsible for hyperthyroidism. T-helper 2 (Th2) cells were expected to be involved in the underlying immune mech- anism, although this is still controversial. The aim of this study was to examine the expression of CXCR6, a chemokine receptor that marks functionally specialized T-cells within the Th1 and T-cyto- toxic 1 (Tc1) cell pool, to gain new insights into the running immune processes. Methods: CXCR6 expression was examined on peripheral blood lymphocytes (PBLs) and thyroid- derived lymphocytes (TLs) of GD patients in flow cytometry. CXCR6 cDNA was quantified in thyroid tissues affected by GD (n ¼ 16), Hashimoto’s thyroiditis (HT; n ¼ 2) and thyroid autonomy (TA; n ¼ 11) using real-time reverse transcriptase PCR. Results: The percentages of peripheral CXCR6þ PBLs did not differ between GD and normal subjects. CXCR6 was expressed by small subsets of circulating T-cells and natural killer (NK) cells. CXCR6þ cells were enriched in thyroid-derived T-cells compared with peripheral CD4þ and CD8þ T-cells in GD. The increase was evident within the Th1 (CD4þ interferon-gþ (IFN-gþ)) and Tc1 (CD8þIFN- gþ) subpopulation and CD8þ granzyme Aþ T-cells (cytotoxic effector type). -
Human Th17 Cells Share Major Trafficking Receptors with Both Polarized Effector T Cells and FOXP3+ Regulatory T Cells
Human Th17 Cells Share Major Trafficking Receptors with Both Polarized Effector T Cells and FOXP3+ Regulatory T Cells This information is current as Hyung W. Lim, Jeeho Lee, Peter Hillsamer and Chang H. of September 28, 2021. Kim J Immunol 2008; 180:122-129; ; doi: 10.4049/jimmunol.180.1.122 http://www.jimmunol.org/content/180/1/122 Downloaded from References This article cites 44 articles, 15 of which you can access for free at: http://www.jimmunol.org/content/180/1/122.full#ref-list-1 http://www.jimmunol.org/ Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication by guest on September 28, 2021 *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2008 by The American Association of Immunologists All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. The Journal of Immunology Human Th17 Cells Share Major Trafficking Receptors with Both Polarized Effector T Cells and FOXP3؉ Regulatory T Cells1 Hyung W. Lim,* Jeeho Lee,* Peter Hillsamer,† and Chang H. Kim2* It is a question of interest whether Th17 cells express trafficking receptors unique to this Th cell lineage and migrate specifically to certain tissue sites. -
Haplotypes in CCR5-CCR2, CCL3 and CCL5 Are Associated with Natural Resistance to HIV-1 Infection in a Colombian Cohort Jorge A
Biomédica 2017;37:267-73 Haplotypes associated with resistance to HIV-1 doi: http://dx.doi.org/10.7705/biomedica.v37i3.3237 BRIEF COMMUNICATION Haplotypes in CCR5-CCR2, CCL3 and CCL5 are associated with natural resistance to HIV-1 infection in a Colombian cohort Jorge A. Vega1,2,3, Simón Villegas-Ospina1, Wbeimar Aguilar-Jiménez1, María T. Rugeles1, Gabriel Bedoya3, Wildeman Zapata1,4 1 Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia 2 Laboratorio de Genética, Dirección Regional Noroccidente, Instituto Nacional de Medicina Legal y Ciencias Forenses, Medellín, Colombia 3 Genética Molecular, Instituto de Biología, Universidad de Antioquia, Medellín, Colombia 4 Grupo Infettare, Facultad de Medicina, Universidad Cooperativa de Colombia, Medellín, Colombia Introduction: Variants in genes encoding for HIV-1 co-receptors and their natural ligands have been individually associated to natural resistance to HIV-1 infection. However, the simultaneous presence of these variants has been poorly studied. Objective: To evaluate the association of single and multilocus haplotypes in genes coding for the viral co-receptors CCR5 and CCR2, and their ligands CCL3 and CCL5, with resistance or susceptibility to HIV-1 infection. Materials and methods: Nine variants in CCR5-CCR2, two SNPs in CCL3 and two in CCL5 were genotyped by PCR-RFLP in 35 seropositive (cases) and 49 HIV-1-exposed seronegative Colombian individuals (controls). Haplotypes were inferred using the Arlequin software, and their frequency in individual or combined loci was compared between cases and controls by the chi-square test. A p’ value <0.05 after Bonferroni correction was considered significant. Results: Homozygosis of the human haplogroup (HH) E was absent in controls and frequent in cases, showing a tendency to susceptibility. -
CXCR6 Deficiency Impairs Cancer Vaccine Efficacy and CD8+ Resident Memory T-Cell Recruitment in Head and Neck and Lung Tumors
Open access Original research J Immunother Cancer: first published as 10.1136/jitc-2020-001948 on 10 March 2021. Downloaded from CXCR6 deficiency impairs cancer vaccine efficacy and CD8+ resident memory T- cell recruitment in head and neck and lung tumors Soumaya Karaki,1,2 Charlotte Blanc,1,2 Thi Tran,1,2 Isabelle Galy- Fauroux,1,2 Alice Mougel,1,2 Estelle Dransart,3 Marie Anson,1,2 Corinne Tanchot,1,2 Lea Paolini,1,2 Nadege Gruel,4,5 Laure Gibault,6 Francoise Lepimpec- Barhes,7 Elizabeth Fabre,8 Nadine Benhamouda,9 Cecile Badoual,6 Diane Damotte,10 11 12,13 14 Emmanuel Donnadieu , Sebastian Kobold, Fathia Mami- Chouaib, 15 3 1,2,9 Rachel Golub, Ludger Johannes, Eric Tartour To cite: Karaki S, Blanc C, ABSTRACT explains why the intranasal route of vaccination is the Tran T, et al. CXCR6 deficiency most appropriate strategy for inducing these cells in the Background Resident memory T lymphocytes (TRM) impairs cancer vaccine efficacy are located in tissues and play an important role in head and neck and pulmonary mucosa, which remains a and CD8+ resident memory immunosurveillance against tumors. The presence of T major objective to overcome resistance to anti- PD-1/PD- T- cell recruitment in head and RM prior to treatment or their induction is associated to the L1, especially in cold tumors. neck and lung tumors. Journal for ImmunoTherapy of Cancer response to anti- Programmed cell death protein 1 (PD- 2021;9:e001948. doi:10.1136/ 1)/Programmed death- ligand 1 (PD- L1) immunotherapy jitc-2020-001948 and the efficacy of cancer vaccines. -
HIV-1 Infection: the Functional Importance of SDF1, CCR2 And
: Curre re nt a R C e h v t i l e a w Mahla, Health Care Current Reviews 2015, 3:2 e s H Health Care: Current Reviews DOI: 10.4172/2375-4273.1000150 ISSN: 2375-4273 Review Article Open Access HIV-1 Infection: The Functional Importance of SDF1, CCR2 and CCR5 in Protection and Therapeutics Ranjeet Singh Mahla* Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, India Abstract The acute or chronic infection of HIV1 resulting to AIDS pandemics is one of the major causes of morbidity and mortality worldwide. The infection, prevalence and propagation of HIV1 depend both on adaptive mutation in virus and host genetic factors. Virus infection to human CD4+ immune cells together is assisted and restricted by various host factors. Presence of mutations in CCR2, CCR5 and CXCR4 ligands SDF1 are associated to protection against HIV1 infection and restriction to AIDS progression. Globally, individuals in various populations harbouring CCR2 (64I), CCR5 (Δ32) and SDF1-3’A mutations are less susceptible to HIV1 infection and decipher delayed onset of AIDS. This review emphasizes the distribution and functional importance of CCR2 (64I), CCR5 (Δ32) and SDF1 (3’A) mutations in protection against HIV1 infection. Lastly the review discuss how CCR2, CCR5 and SDF1 can be explored for development of antagonistic for protection against HIV1 infection. Keywords: HIV1; Host genetic factors; Chemokine receptors; SDF1 and HIV1 Therapeutics The chemokine SDF1 is natural ligand of C-X-C chemokine Introduction receptor type 4 (CXCR4) has been investigated for its inhibitory role onto entry of HIV1 into its target CD4+ cells through bindings to Infection of human immunodeficiency virus (HIV)-1, the causative CXCR4 which is a co receptor for T tropic HIV1 entry. -
Aging T Cell Chemokine Receptor Expression In
The Journal of Immunology T Cell Chemokine Receptor Expression in Aging1 Ruran Mo,* Jun Chen,* Yin Han,* Cecelia Bueno-Cannizares,* David E. Misek,† Pascal A. Lescure,† Samir Hanash,† and Raymond L. Yung2* Changes in chemokine receptor expression are important in determining T cell migration and the subsequent immune response. To better understand the contribution of the chemokine system in immune senescence we determined the effect of aging on CD4؉ T cell chemokine receptor function using microarray, RNase protection assays, Western blot, and in vitro chemokine transmi- ,gration assays. Freshly isolated CD4؉ cells from aged (20–22 mo) mice were found to express a higher level of CCR1, 2, 4, 5, 6 and 8 and CXCR2–5, and a lower level of CCR7 and 9 than those from young (3–4 mo) animals. Caloric restriction partially or completely restored the aging effects on CCR1, 7, and 8 and CXCR2, 4, and 5. The aging-associated differences in chemokine receptor expression cannot be adequately explained by the age-associated shift in the naive/memory or Th1/Th2 profile. CD4؉ cells from aged animals have increased chemotactic response to stromal cell-derived factor-1 and macrophage-inflammatory protein- 1␣, suggesting that the observed chemokine receptor changes have important functional consequences. We propose that the aging-associated changes in T cell chemokine receptor expression may contribute to the different clinical outcome in T cell chemokine receptor-dependent diseases in the elderly. The Journal of Immunology, 2003, 170: 895–904. he precise mechanisms linking the aging immune system (6–8). T cell-tropic HIV-1 isolates (X4 strains) preferentially use to diseases in the elderly are poorly understood. -
Role of Chemokines in Hepatocellular Carcinoma (Review)
ONCOLOGY REPORTS 45: 809-823, 2021 Role of chemokines in hepatocellular carcinoma (Review) DONGDONG XUE1*, YA ZHENG2*, JUNYE WEN1, JINGZHAO HAN1, HONGFANG TUO1, YIFAN LIU1 and YANHUI PENG1 1Department of Hepatobiliary Surgery, Hebei General Hospital, Shijiazhuang, Hebei 050051; 2Medical Center Laboratory, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai 200065, P.R. China Received September 5, 2020; Accepted December 4, 2020 DOI: 10.3892/or.2020.7906 Abstract. Hepatocellular carcinoma (HCC) is a prevalent 1. Introduction malignant tumor worldwide, with an unsatisfactory prognosis, although treatments are improving. One of the main challenges Hepatocellular carcinoma (HCC) is the sixth most common for the treatment of HCC is the prevention or management type of cancer worldwide and the third leading cause of of recurrence and metastasis of HCC. It has been found that cancer-associated death (1). Most patients cannot undergo chemokines and their receptors serve a pivotal role in HCC radical surgery due to the presence of intrahepatic or distant progression. In the present review, the literature on the multi- organ metastases, and at present, the primary treatment methods factorial roles of exosomes in HCC from PubMed, Cochrane for HCC include surgery, local ablation therapy and radiation library and Embase were obtained, with a specific focus on intervention (2). These methods allow for effective treatment the functions and mechanisms of chemokines in HCC. To and management of patients with HCC during the early stages, date, >50 chemokines have been found, which can be divided with 5-year survival rates as high as 70% (3). Despite the into four families: CXC, CX3C, CC and XC, according to the continuous development of traditional treatment methods, the different positions of the conserved N-terminal cysteine resi- issue of recurrence and metastasis of HCC, causing adverse dues. -
CCR5 in T Cell-Mediated Liver Diseases: What's Going On? Maureen N
CCR5 in T Cell-Mediated Liver Diseases: What's Going On? Maureen N. Ajuebor, Jillian A. Carey and Mark G. Swain This information is current as J Immunol 2006; 177:2039-2045; ; of September 29, 2021. doi: 10.4049/jimmunol.177.4.2039 http://www.jimmunol.org/content/177/4/2039 Downloaded from References This article cites 62 articles, 20 of which you can access for free at: http://www.jimmunol.org/content/177/4/2039.full#ref-list-1 Why The JI? Submit online. http://www.jimmunol.org/ • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication *average by guest on September 29, 2021 Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2006 by The American Association of Immunologists All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. THE JOURNAL OF IMMUNOLOGY BRIEF REVIEWS CCR5 in T Cell-Mediated Liver Diseases: What’s Going On?1 Maureen N. Ajuebor, Jillian A. Carey, and Mark G. Swain2 The chemokine receptor CCR5 came into worldwide Over the past 10 years, chemokines have been the focus of a prominence a decade ago when it was identified as one of great deal of research pertaining to their role in promoting leu- the major coreceptors for HIV infectivity. -
Origin of CCR5-Delta 32 Mutation
Origin of CCR5-Delta 32 Mutation Name Date What is the CCR5-Delta 32 Mutation anyway? “The transmembrane CCR5 chemokine receptor is used by HIV strains to enter cells of the immune system such as macrophages and CD4+ T cells. The CCR5-Δ32 deletion prevents the expression of the receptor on the cell surface and provides almost complete resistance to HIV-1 infection in homozygous individuals and partial resistance in the heterozygous state.” The average occurrence of the CCR5-Delta 32 deletion allele is estimated to be 10% in Caucasian European inhabitants, but it is almost absent among native Sub-Saharan African, Asian, and American Indian populations. Thesis: The origin of CCR5-Delta 32 and the reason of why only such selective group of Europeans carry this mutation has now been a topic of discussion. When it was first discovered, scientists believed that the bubonic plague, also known as the Black Death (1346-50 approx.), was the answer to the mutation. Recent studies have suggested that this mutation has been present since before the bubonic plague, being the Black Death only part of the history behind the origin of CCR5-Delta 32. Previous Theories: The single pandemic of the Black Death, which killed Theory 1 about 40% of the population of Europe. Epidemics of bubonic plague every 10 years for Theory 2 400 years. Smallpox epidemics every five years in Europe Theory 3 for at least 620 years from 1347 to 1970. Theory One: “The single pandemic of the Black Death, which killed about 40% of the population of Europe.” This theory is perhaps the most popular, but studies have demonstrated that the mutation did not result form a single disease strike, but from recurrence over several centuries. -
CCR6 IL-17 Express the Chemokine Receptor Human T Cells That Are
Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR6 This information is current as Satya P. Singh, Hongwei H. Zhang, John F. Foley, Michael of September 26, 2021. N. Hedrick and Joshua M. Farber J Immunol 2008; 180:214-221; ; doi: 10.4049/jimmunol.180.1.214 http://www.jimmunol.org/content/180/1/214 Downloaded from References This article cites 58 articles, 27 of which you can access for free at: http://www.jimmunol.org/content/180/1/214.full#ref-list-1 http://www.jimmunol.org/ Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication by guest on September 26, 2021 *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2008 by The American Association of Immunologists All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. The Journal of Immunology Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR61 Satya P. Singh, Hongwei H. Zhang, John F. Foley, Michael N. Hedrick, and Joshua M. Farber2 Some pathways of T cell differentiation are associated with characteristic patterns of chemokine receptor expression.