İstanbul University Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula

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Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 1/125 Table of Contents 1st Year Courses ...... 3 Course 1.1: Introduction to Medical Sciences ...... 3 Course 1.2: Cell Tissue and Organ Systems I ...... 8 Course 1.3: Cell Tissue and Organ Systems II ...... 12 Course 1.4: Introduction to Clinical Medicine ...... 19 2nd Year Courses ...... 25 Course 2.1: Locomotor System ...... 25 Course 2.2: Cardiovascular System ...... 28 Course 2.3: Respiratory System ...... 32 Course 2.4: Hematopoietic System, Immunology, Microbiology ...... 35 Course 2.5: Gastrointestinal System ...... 39 3rd Year Courses ...... 43 Course 3.0: Introduction to Internal Medicine Practice ...... 43 Course 3.1: Nerve System and Sensory Organs ...... 45 Course 3.2: Genitourinary System ...... 49 Course 3.3: Topographic Anatomy - Biostatistics - Deontology ...... 53 Course 3.4: Endocrine System and Metabolism ...... 56 Course 3.5: Clinical Microbiology and Infectious Diseases ...... 59 4th Year Clerkships ...... 62 Internal Medicine ...... 63 Çocuk Sağlığı ve Hastalıkları / Pediatrics ...... 67 Gynecology and Obstetrics ...... 71 General Surgery ...... 74 Radiology ...... 77 Anesthesiology and Reanimation...... 83 Urology ...... 85 5th Year Clerkships ...... 87 Orthopedics and Traumatology ...... 88 Physical Medicine and Rehabilitation...... 90 Neurology...... 92 Neurosurgery ...... 94 Psychiatry ...... 96 Ophtalmology...... 98 Otorhinolaryngology ...... 100 Pulmonary Medicine ...... 102 Cardiovascular Surgery ...... 104 Thoracic Surgery ...... 106 Pediatric Surgery ...... 108 Radiation Oncology ...... 109 Plastic and Reconstructive Surgery...... 111 Nuclear Medicine ...... 113 Cardiology ...... 114 Infectious Diseases ...... 118 Forensic Medicine ...... 120 Dermatology...... 121 Public Health ...... 123 6th Year Internships ...... 125

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 2/125 1st Year Courses Course 1.1: Introduction to Medical Sciences Chair: Assoc. Prof. Dr. M. Selman Demirci, Anatomy Phone: +902124143000/21568 Secretary: +902124143000/21561 E-mail: [email protected] Vice Chairs: Prof. Dr. Remisa Gelişgen, Biochemistry Assoc. Prof. Dr. Semra Özdemir, Biophysics

Members: Prof. Dr. Ayten Altıntaş, Deontoloji ve Tıp Tarihi, Deontology and History of Medicine Assoc. Prof. Dr. Suphi Vehid, Biostatistics

Semester: 1

Credit of Course: 10

ECTS Credit of Course: 10

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%) Anatomy 15 4 20 Biophysics 10 4 14 Biostatistics 14 8 21 Biochemistry 18 6 26 Deontology and History of Medicine 13 0 15 Computer in Medicine 0 6 4 Total 70 28 100

Course aims and learning outcomes Course content Multidisciplinary course “Introduction to Medical Sciences” contains,Anatomy,Biophysics,Biostatistics,Biochemistry,Deontology and History of Medicine,Computer in Medicine lessons.

Course aims Through anatomy lessons, to the newly started students to medical school, to introduce 'what is anatomy?' and basic terminology, to teach the basic knowledge and classification about the places, names, anatomic features of „organs‟ in all systems to the students of this semester. Thus, to enable them to realize the importance of anatomy in medical education.

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 3/125 With Biophysics lessons, it‟s aimed that principle function of laser; formation and properties of ultrasound with the use of these features in medicine and explanation of the research areas; understanding of the cybernetic concept and specifying the importance of the clinical use through determining the research areas; determining the basic biophysical properties of protection from radiation use of radionuclides in medicine in vitro-in vivo conditions; the importance of optimization of necessary radiation dose in the treatment planning; education of study areas and biophysical principles of medical imaging methods as endoscopy, x-ray, computed tomography (CT), magnetic resonance imaging (MRI), SPECT and PET techniques..

Through the biochemistry lectures; after providing the students gain the basic knowledge and concepts about the elemental structures, chemical bonds, functional groups and chemical reactions of biomolecules in human organism, teaching the classification, structural properties and biomedical importance of nucleic acids, carbohydrate, lipid, amino acid and protein molecules which are the basic molecules of cells and tissues, stating the basic knowledge about the relevance of the molecular structures and functions of hemoglobin and myoglobin, plasma lipoproteins, serum proteins, immunoglobulins and acute phase reactants, getting to comprehend the importance of plasma proteins which are clinically important and their significance in the diagnosis and following up of the diseases, providing this basic biochemistry knowledge a basis, primarily for the biochemistry lectures which will be taught in the cell, tissue and organ system lecture course and for the clinical lectures which will be taught afterwards is intended.

The purpose of Biostatistics course in this committee is : Ensuring appropriate reasoning about the concepts and issues related to the processes of scientific research such as variables, , sampling, experimental design, probabilistic interpretation , capability for their applications and the tendency of adaptation to solve similar issues.

The purpose of the History of Medicine courses is to provide information about development of medicine in order to introduce the current medicine to new students. It is provided information about identity of physician, things made for diagnosis of disease and treatment method from the primitive man to the Ancient Age and from there to the Middle Age. It is explained the beginning of the Enlightenment in the West and how mathematics, physics and chemistry have affected the medicine. It is tried to be comprehended the system of thought that have given shape to the current medicine, the beginning of the experimental medicine and how the discovery of the world of microbiology was made. In this way the History of Medicine courses intend to be comprehended better education of the current medicine with information about the science from which the Modern Medicine has arisen and its affection to the medicine.

Learning A student who completes anatomy lesson in that course; can count out, description outcomes of anatomy, basic terminology, motion system, circulation system, respiratory system, digestive system, urinery and reproductive system, endocrin system, nervous system and sensory organs by their Latin names; explain the organs places, boundaries and basic anatomic features in these systems. He/she can recognise and show the organs of these systems on cadaver and scaled model. He/she knows the basic working mechanisms of body systems and their relations with each other.

Students, who attend the biophysics lessons, can know the intended use of laser and ultrasound in medical treatment and surgery, potential hazards and the selection of the appropriate laser; can do similar simulations with organism, applying the cybernetic principles in various medical fields; can evaluate the relative errors of detected counts on radiation detection; can measure absorption of radiation and can calculate the half-value thickness in variety tissue sections; can identify the most accurate method for imaging the internal structures of living organisms and can explain the biophysical properties of the method.

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 4/125 Students completing this biochemistry lectures in this course should be defining and arguing the structural properties, functions and biomedical importance of nucleic acids, carbohydrates, lipids, amino acids and proteins which are the basic biomolecules of the cells and tissues in human organism, should be defining and arguing the importance of the relevance of the molecular structures and functions of hemoglobin and myoglobin, plasma lipoproteins, serum proteins, immunoglobulins and acute phase reactants and plasma proteins which are important in clinical diagnosis. Students should be integrating the basic knowledge learned via these subjects with the knowledge which will be taught in the cell, tissue and organ systems lectures and should be interpreting and evaluating the resultant changes related to the biomolecules in physiological and pathological conditions in human metabolism from a biochemical point of view.

Students who completed the biostatistics course: Can explain the uncertainty , a feature common in the field of medicine, knows the use of methods to ensure the analysis and evaluation of such issues. Can examine the types and elements of the concept of causality , can evaluate basic concepts of biostatistics in the framework of probability, probability distributions, and probabilistic judgement criteria , acquires the ability of making scientific analysis based on these informations and to recognize the structure of the elements in this area.

At the end of the History of Medicine courses; students learn how the medicine was understood in historical processes commentated in the History of Medicine courses and definitions about rational drugs in treatment. Thus it will be raised awareness in students who study the current medicine knowledge. The target of the History of Medicine courses is to understand, comprehend the current medicine and in particular to ensure that the future medicine is adapted. At the end of these courses, the Faculty of Medicine students are provided to comprehend the system of thought which the medicine has experienced. These courses intend to allow them distinguish that diagnosis and treatment to be learnt by students during their training of medicine have arrived at the present days with which development and to allow them be open for innovations which will rise to the surface in the future.

Teaching Lectures and laboratory practices. methods and strategies

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 5/125 Lectures of the Course No Title 1. The Medical Practitioner in History 2. Philosophical Bases of Medicine 3. Introduction to Anatomy 4. Locomotor System (1/3) 5. Introduction To Biostatistics, Aims, Brief History, Basic Concepts 6. Biomolecules: General structural properties 7. Locomotor System (2/3) 8. Basic Concepts Of Biostatistics, Measuring, Coding, Collection And Presentation Of Data. 9. Locomotor System (3/3) 10. Functional groups in biomolecules 11. The Research Methodology in Medicine, Causality, Research Designs 12. Vascular System (1/2) 13. Descriptives Of The Quantitative Data Series 14. Biochemical reactions 15. Vascular System (2/2) 16. Nucleic acids and nucleotides: Structure and functions (1/2) 17. Nucleic acids and nucleotides: Structure and functions (2/2) Probability, Basic Concepts, Introduction To Theoretical Probability Distributions 18. (Binomial, Poisson) 19. Anatomy of the Human Body as Described and Illustrated in Historical Sources 20. Introduction To Continuous Probability Distributions (Normal Distribution) 21. Tests Of Significance I (Parametric Hypothesis Tests) 22. Respiratory System 23. Functions of Organs As Viewed in History 24. Carbohydrates : Structure and classification 25. Nervous System (1/2) 26. Nervous System (2/2) 27. Tests Of Significance II (Parametric Hypothesis Tests) 28. Tests Of Significance III (Nonparametric Methods) 29. Monosaccharides, glycosides, oligosaccharides 30. Polysaccharides and glycoproteins 31. Etiology of Disease and Methods Used in Diagnosis Before the Scientific Era 32. Cybernetics and Medical Practices 33. Proteoglycans, mucopolysaccharides 34. Gastrointestinal System (1/2) 35. Evaluation Of Qualitative Data (Chi-Square Test) 36. Gastrointestinal System (2/2) 37. Laser and Medical Practices 38. Lipids: Functions. Fatty acids: Nomenclature and classification 39. Relation Between Variables I (Correlation) 40. Relation Between Variables II (Regression) 41. Urogenital System (1/2) 42. Ultrasound and Medical Practices 43. Empirical Methods of Treatment 44. Struggle Against Infectious Epidemic Diseases in History 45. Urogenital System (2/2) 46. Triacylglylcerols, phospholipids, glycolipids 47. Design Of Experiments, Elements Of Multivariate Analysis 48. Radiation Biophysics 49. Isoprenoids, poliprenoids, steroids 50. Sampling Techniques, Sample Size 51. Endocrine System 52. Development of Surgical Instruments and Operations 53. Sensory Organs 54. Radiation Biophysics 55. Plasma lipoproteins

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 6/125 No Title 56. Biological Effects of Non-Ionisan Radiation and Protection Principles 57. Introduction of Measurement and Medical Instruments 58. Amino acids : Structural properties 59. Medical Experimentation and Evolution of Medicine Evidence 60. Peptides and proteins : Structural properties 61. Imaging Techniques 62. Hemoglobin and myoglobin: Structure and function 63. Institutionalization in the Field of Medicine 64. Imaging Techniques: Endoscopy, Rontgen 65. Historical Bases of Alternative Medicine 66. Serum proteins, immunoglobulins, acute phase reactants 67. Computerized Tomography (CT), Magnetic Resonance (MR) 68. Change of Ethical Values in Medical Practice Through History 69. Plasma proteins in clinical diagnosis 70. SPECT, PET

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 7/125 Course 1.2: Cell Tissue and Organ Systems I

Chair: Prof. Dr. Selma Yılmazer, Tıbbi Biyoloji (Medical Biology) Phone: +902124143000/22032 Secretary: +902124143000/21801 E-mail: [email protected] Vice Chairs: Prof. Dr. Ş. Selmin Toplan, Biophysics Prof. Dr. Gülnur Andican, Biyokimya Biochemistry

Semester 1

Credit of Course: 13

ECTS Credit of Course: 13

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%) Biophysics 35 12 36 Biochemistry 25 12 28 Medical Biology 36 8 36 Total 96 32 100

Course aims and learning outcomes Course content Cell Tissue and Organ Systems I course informs molecular cell biology, biochemistry and biophysics. Also this course includes acid-base balance parameters, elements, biomolecules vitamins, enzymes, and basic metabolism subjects. Course aims Teaching the structure and function of cells at molecular level and understanding the structure and function of biomolecules, vitamins, enzymes and their clinical importance which will provide basis for course 1003 (Cell, tissue and organ systems II). Defining the importance of molecular mechanisms of cellular functions in order to understand the molecular basis of human diseases. Learning At the end of this course the students will be able to: outcomes Explain properties of Prokaryotic and eukaryotic cells and Evolution of cell Get information about the examination methods of cell; Cell culture, hybrid cells Practice of microsurgical procedures to the living cells, fractionation of cells and analysis of their molecules and Microscopic examination methods of cell Explain the molecular structure and function of cellular membranes,permeability specialities , Diffusion Osmosis and Active Transport ,membrane potantiel, nörobiyofizik,iyon kanalları ve voltaj-klamp tekniği ile Phagocytosis, pinocytosis, receptor mediated endocytosis Provide information about the specializations of the cell surface: Microvillus, cilia and flagella, Cell adhesion molecules and Cell-cell junctions ,Cell to cell communication and gap junctions, Cell- Extracellular Matrix junctions ,Extracellular matrix and its proteases Explain the structural and molecular properties and functions of the cell organelles; Structure, function and biosynthesis of ribosome, Protein synthesis and genetic

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 8/125 code The mitochondrion, mitochondrial DNA and inheritance, Structure and function of the endoplasmic reticulum , The Golgi complex and protein sorting, Lysosomes and lysosomal diseases Peroxisom and peroxsizomal diseases, centriole Get information about the cell nucleus, nuclear envelope, nuclear pores and Transport through the nuclear envelope The nucleolus, nuclear matrix Active and inactive chromatin, The fine structure of chromatin Chromosomes and higher order structure of chromosomes, centromers, telomers Explain structure and function of cytoskeleton, microtubulles and intracellular transport, microfilaments and intermediate filaments Point out the importance of Cell signalling,signal molecules, Signal transmission with cell surfaces receptors and intracellular receptors,intracellular signalling pathways Explain molecular basis of cell aging, Cell death (apoptosis) and Molecular basis of cell differentiation Get information about the Immunobiology and Stem Cell Biology Dscuss the importance of water metabolism, body water and electrolytes. define the concept of pH. explain acid-base balance and disorders. point out the importance of physiological buffers and blood gases. prepare a buffer solution and calculate the pH of buffer solution and the change in the pH. Describe the basic information (structures, sources, properties, absorption, transport, storage, functions, metabolic reactions they participate in, clinical significance, deficiency states, interactions) on each of the water- and fat- soluble vitamins as well as macrominerals, electrolytes, essential trace elements required during the metabolic pathways of macromolecules as well as for a healthy and an balanced nutrition. explain the methods and principles for the determination of Ca and P and perform at least one procedure of Ca and P determinations. discuss the laboratory findings. Explain general enzyme characteristics, classification, kinetics, mechanism of action, regulation, its importance in diagnosis and therapy. in laboratory analysis to be able to draw a grafics, based on experimental conditions related to enzyme kinetics and to discuss the importance of the findings. Define the concept of bioenergetics, the laws of thermodynamics and the role of ATP. explain the anabolic and catabolic pathways, the regulation of overall flux through a pathway and the location and integration of metabolic pathway. Discuss the importance of the energy that must use for living cells. explain reactions involving oxidation and reduction. notice the importance of the respiratory chain and oxidative phosphorylation and the related diseases Describe the principles of spectrophotometry and apply this method on experimental conditions. Explain the basic mechanisms of vision and hearing Learn and gain the ability in practicing the electrical currents on tissue both in diagnosis and therapy Gain ability in observing the biophysical mechanisms in circulatory system and the aroused problems Use the knowledge related to action potential, synaptic transmission and muscle contraction in laboratory and clinical applications. Teaching Lectures and laboratory practices methods and strategies

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 9/125 Lectures of the Course No Title 1. Body Fluids; Special Features, General Composition, Determination Methodes 2. Distribution Types of the Matters in Body Fluids 3. Water, water metabolism and balance of electrolytes 4. Examination methods of cell; Cell culture, hybrid cells 5. Biophysical Characterictics of Living structures, Surface Tension Practice of microsurgical procedures to the living cells, fractionation of cells and analysis 6. of their molecules 7. Buffering systems, acid-base balance and its disorders 8. Vitamins: General properties 9. Microscopic examination methods of cell 10. Description and Measurement of pH, Activity of Hydrogen Ions 11. Regulation of the Acid-Base Equilibrium, Buffering Power of Body Fluids 12. Prokaryotic and eukaryotic cells 13. Fat-soluble vitamins 14. Effects of Systems on Compensation of Asid-Base Equilibrium Disorders 15. Changes in Acid-Base Parameters in Acid-Base Equilibrium Disorders 16. Water-soluble vitamins (1/2) 17. Structure and function of cellular membranes 18. Biophysical Properties of Blood Gases, Blood Gas Measutrement methods Blood Gas Electrodes, Blood Sample Drawing and Determination of Acid-Base 19. Equilibrium Parameters by Nomogram 20. Organisation of cell membrane and permeability Specialities 21. Structure and function of cellular membranes 22. Structure, function and biosynthesis of ribosome 23. The mitochondrion, mitochondrial DNA and inheritance 24. Water-soluble vitamins (2/2) 25. Biophysical Bases of Ionic Diffusion and Osmosis 26. Biophysical Mechanisms in Active Transport Membrane Potential, Neurobiophysics and Biophysical Bases of Data Transmission in 27. Organism 28. Calcium, phosphate, magnesium 29. Sodium, potassium, chloride 30. Formation Mechanisms of Resting Membrane Potential, Ion Channels 31. Protein synthesis and genetic code 32. Structure and function of the endoplasmic reticulum 33. Action Potentials, Ionic Currents,Voltage Clamb Technique 34. Iron, zinc, copper, manganese, chromium 35. Molecular mechanisms of protein synthesis in endoplasmic reticulum 36. Biophysics of Synaptic Conduction 37. Selenium, cobalt, molybdenum, nickel, lithium and others 38. The Golgi complex and protein sorting 39. Potentials in Synaptic Conduction 40. Bioenergetics 41. Lysosomes and lysosomal diseases 42. Biophysics of Muscle Contraction 43. Enzymes: General properties 44. Peroxisome, centriole 45. General concepts of enzymatic action 46. Mechanism of action of various enzymes 47. Specializations of the cell surface: Microvillus, cilia and flagella 48. Enzyme kinetics 49. Circulaton Biophysics,Hydrostatic Factor in Circulation and Hemodynamic Principles 50. Mechanisms of ciliary motility 51. Cell adhesion molecules 52. Cell-cell junctions and tight junctions 53. Efficiency and Power of the Heart , Blood Flow and Pressure Measuring Methods

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 10/125 No Title 54. Enzyme inhibition 55. Extracellular matrix and its proteases 56. Cell to cell communication and gap junctions 57. Hemarheology; Aims, Fluidity Specialities of blood Flow 58. Blood Viscosity, Erythrocyte Deformability and Other Rheological Specialities 59. Nucleus, nuclear envelope, nuclear pores 60. Regulation of enzyme activity (1/2) 61. The nucleolus, nuclear matrix 62. Transport through the nuclear envelope 63. Regulation of enzyme activity (2/2) Atomic Specialities That Determine the Structural Physical Characterictics of 64. Biomolecules, Reasons of Moleculer Changes and liveness Interactions Between Molecules and Orientation, Intermolecular Recognation and 65. Relation of Recognation With Structural Specialities 66. Membranes: Chemical structure and organisation 67. Active and inactive chromatin, The fine structure of chromatin 68. Chromosomes and higher order structure of chromosomes, centromers, telomers 69. Molecular movements at membrane; passive transport systems Biomoleculer Activation and Inactivation, Principles and Laws of Biomoleculer Life 70. Success; Intercellular and Intracellular Regulation of Molecular Processes 71. Phagocytosis, pinocytosis, receptor mediated endocytosis 72. Enviromental Specialities that Biomolecules Take Place In 73. Cytoskeleton I: Microtubulles and intracellular transport 74. Active transport systems 75. Receptors and signal transduction 76. Cytoskeleton II: Microfilaments and intermediate filaments 77. Cell signalling 78. Introduction to metabolism, Biologic oxidation 79. Regulation of molecular functioning inside and outside the cell 80. Classification of Principles of Spectrophotometry, Light Energy, Organism Relation Molecular Mechanisms of Convertion of the Light Energy in Organism, Electrogenic 81. Action Potential 82. Electron transport chain 83. Signal transmission with cell surfaces receptors and intracellular receptors 84. Molecular basis of cell aging 85. Oxidative phosphorylation 86. Mechanical Energy Organism Relation, Organisation of Coclear Potential and Ionic Bases 87. Cell death (apoptosis) 88. Physical and Chemical Effects of Direct Current, Effects of Direct Current on Tissue 89. Evolution of cell 90. Current specialties According to Frequency and Intensity 91. Molecular basis of cell differentiation 92. Immunobiology 93. Control Mechanisms in Replication and External Intervention 94. Stem Cell Biology 95. Immunobiophysics General Concepts, Reorganisation of DNA 96. Choronaxie, Rhobase, Stimulation of human by Direct Currents, Surgical Galvanism

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 11/125 Course 1.3: Cell Tissue and Organ Systems II

Chair: Prof. Dr. Turgut Ulutin, Tıbbi Biyoloji (Medical Biology) Phone: +902124143000/22208 Secretary: +902124143000/21801 E-mail: [email protected] Vice Chairs: Prof. Dr. Gökhan Metin, Physiology Assoc. Prof. Dr. Emine Elif Güzel, Histology and Embryology Members: Prof. Dr. Bora Barutçu, Biophysics Prof. Dr. Orkide Donma, Biochemistry

Semester: 2

Credit of Course: 13

ECTS Credit of Course: 13

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%) Biophysics 9 10 11 Biochemistry 10 0 8 Physiology 19 4 18 Genetics 28 8 27 Histology and Embryology 37 12 36 Total 103 34 100

Course aims and learning outcomes Course content Multidisciplinary course “Cell Tissue and Organ Systems II” contains, anatomy, biophysics, biostatistics, biochemistry, history in medicine and computer in medicine lessons.

Course aims Biophysics: Functional Structure of the Proteins and It‟s Biophysical Specific Features, Thermodynamic Principles and Regulation of Energy Transfer in Living Structures, Biophysical specialties of Usage of Metabolic Energy in Biological Work, Irregular Cell Proliferation Mechanisms, Nanotechnology and its medical applications, Biomechanics, Biological Effects of Ionian Radiation, Effects of Radiation in Cell, Biophysics of Cell Proliferation and Differentiation, Tracers, Radio sensitivity, Radiopharmaceuticals and Their Biological Behavior. The course board should provide groundwork about, the main structure of a cell, the functions and structures of cells & tissues, cell cycles, the types of transmission between cells, the normal structures & functions of a body system. Even it seems like every vital is moving independently, the effects from inner & outer dynamics are bonded to the mechanic rules. Because of this, it should have information about the important research & development area of biomechanics. The nanotechnology could create intervention of the living systems in the molecular levels, in this aim the nanotechnology should be considered as the new and

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 12/125 providing diagnosis & cure method. It should explain the biological affects & protection methods about radiation. It should understand the radiopharmaceuticals Biological Behavior Mechanisms.

Biochemistry: Digestion of dietary nucleoproteins. Metabolisms of purine and pyrimidine nucleotides. Diseases related to the synthesis as well as degradation pathways. DNA mutations and repair mechanisms. Stages of replication and transcription. Posttranscriptional events. General principles and stages of translation. Posttranslational modifications. General mechanisms on the regulation of gene expression and protein targeting. Growth, differentiation, the loss of control on growth and tumor development. Biochemical alterations observed in tumor cells. Laboratory tests for the detection of such alterations. To discuss the importance of metabolism of nucleotides, stages of replication and transcription in prokaryotes and eukaryotes, their regulations, associated enzymes and accessory proteins as well as types of mutations caused by several agents for the understanding of metabolic alterations at molecular level, particularly in genetic diseases. To emphasize the clinical significance of repair mechanisms and the related defects. To acquire proficiency about the importance of the inhibition of transcription in treatment protocols. To explain posttranscriptional events and their regulations. To explain the mechanism of action of HIV inhibitors. To explain the stages of translation and the effects of inhibitors during the course of treatment. To explain regulation of gene expression within the scope of metabolic events in the body. To explain the processes those take place within the scope of protein targeting. To introduce what type of a disease cancer is, how it develops, the roles of oncogenes during the course of cancer development. To emphasize the role of the laboratory during the monitoring of cancer patients as well as the clinical significance of tumor markers on diagnosis.

Physiology: This course is a continuation of the Cell Tissue and Organ Systems I and provides basis for Clinical Medical Sciences. This course aims to apprehension of the structure and function of cells and tissues and their clinical importance in physiological level.

Basic genetics: Organization of human genom and gene structure,DNA structure and replication, mutations, DNA repair ,gene expression;transcription and protein synthesis ,regulation of gene expression, recombinant DNA technology Genetic engineering and human genom project . cell division and cell cycle control system ,Cell cycle regulation and cancer development, cancer causing genes, Meiotic division and formation of gamets, chromosome structure,Isolation of chromosomes ,Chromosomal abnormalities, Mendelian inheritance , autosomal inheritance Multifactorial inheritance, mitochondrial inheritance, Recessive inheritance, X linked inheritance, concept of Genomic imprinting, uniparental disomy,immunogenetics. To discuss the importance of genetics and explain the basic principles of molecular genetics, organization of human genom and gene structure,DNA structure and replication ,the clinical significance of mutations, To explain molecular steps of gene expression;transcription and protein synthesis ,regulation of gene expression , To acquire proficiency about the principles of recombinant DNA technology Genetic engineering and human genom project . To emphasize the significance of the cell division and cell cycle control system for the understanding of cancer development and cancer causing genes.To explain structure of chromosomes,Isolation of chromosomes and Chromosomal abnormalities, Mendelian inheritance (definitions), autosomal inheritance Multifactorial inheritance, mitochondrial inheritance, Recessive inheritance, X linked inheritance, concept of Genomic imprinting, uniparental disomy, To explain The general properties of genetic disorders

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 13/125 Histology: General histology Histology & its methods of study The microscopical structure of the cell and the four fundamental tissues of the body (epithelial, connective, nerve, and muscle tissue). General embryology Embryonic molecular regulation and signaling. Gametogenesis: Conversion of germ cells into male and female gametes. First week of development: Ovulation to implantation. Second week of development: Bilaminar germ disc. Third week of development: Trilaminar germ disc. Third to eighth weeks: The embryonic period. The gut tube and the body cavities. Third month to birth: The fetus and placenta. General aspects of birth defects and prenatal diagnosis.

General Histology To teach and discuss the importance of the General Histology, it‟s methods of study, and the microscopical structure of the epithelial, connective, nerve, and muscle tissues. General Embryology To teach and discuss; the importance of the embryonic molecular regulation and signaling, what is gametogenesis and how germ cells convergence to male and female gametes, the important events in the 1st week of development from ovulation to implantation, the events in 2nd week of development and formation of bilaminar germ disc, 3rd week of development and formation of trilaminar germ disc, the embryonic period of 3rd to 8th weeks of development, formation of the gut tube and the body cavities, development and growth of the fetus during 3rd month to birth and formation of placenta, and finally emphasize the general aspects of the birth defects and their prenatal diagnosis.

Learning Biophysics: The cell in the living organism, should recognize the organs & the outcomes systems, should define them with the proper terminology, compare & explain between the related tool, methods & principles. The main structures of cells & tissues should comprehend the fundamentals, functions and relations. It should understand & regard the principle of biochemical & physical chemistry affects between the inner cell & between the cells. To ensure & protection of the homeostasis in the organism, the structure & functions of the systems should be defined & thought as a whole.

Biochemistry: The student will be able to -introduce digestion of nucleic acids, -find out the synthesis pathways of purine nucleotides, key regulatory points and their significance -explain the clinical consequences of deficiencies or overactivities of the related enzymes.

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 14/125 -provide information about uric acid and the related diseases. -explain the defects related to synthesis and degradation pathways of pyrimidine nucleotides. -explain the general features of replication in prokaryotes and eukaryotes as well as how DNA synthesis is performed with great fidelity. -find out the compounds and the intermediates participating in replication process as well as the enzymes in the replication fork and their functions. -explain the control mechanisms during replication -explain the inhibition of replication and DNA mutations -get information about repair mechanisms and their significance -list the types of RNA -list the key molecules, stages and control mechanisms of transcription -notice the importance of transcription during physiological and pathological events -explain defects in transcription -point out the importance of the inhibition of transcription during treatment protocols -explain posttranscriptional events, parameters, which are involved in the process and the period prior to translation -List the basic principles and steps of translation, posttranslational modifications and the inhibitors of translation along with their mechanisms of action -Give some information about the general biochemical mechanisms, which play roles in regulation of gene expression as well as protein targeting and also diseases caused by the defects in these regulatory mechanisms -provide information about genes regulating cell cycle, DNA repair genes, prooncogenes, oncogenes, tumor suppressor genes, genes regulating apoptosis and the events during the course of cancer development -define the concept of tumor marker. Know the roles of tumor markers in cancer screening, diagnosis, differential diagnosis, staging, prognosis determination, planning and monitoring of treatment, detection of recurrence. Know the properties of an ideal tumor marker. List tumor markers used in the clinical disciplines. Know that they are detectable in serum and also other physiological fluids such as urine, CSF, BAL as well as in the cancerous tissues of the patients, but also in some benign conditions. Know the necessity of preferring noninvasive and low-cost techniques

Physiology: Understanding the concept of homeostasis in the organism. Understanding the properties of body fluid compartments and their interrelations. Understanding the exchange of fluids between the intracellular and extracellular fluid compartments, and how the osmotic equilibrium is established. Learning the physical properties of blood and the conditions that change these properties. Understanding the physiologic structure of the cell membrane. Learning the mechanisms which allow the passage of substances through the cell membrane and the tissue specific transport mechanisms. Understanding how resting membrane potential occurs and the role of ion channels in this process. Describing the ionic basis and conditions of excitation and types of action potential. Understanding the mechanism of excitation in excitable tissues.Understanding the physiological properties of nerve cells which have an excitable and conducting nature. Describing the classification of the nerve fibers and their fiber specific functions. Understanding the types of communication in the intercellular communication processes and the intra-and extracellular mechanisms that take part in intercellular communication. Understanding the cellular and electrical properties of smooth and cardiac muscle. Describing the

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 15/125 ionic basis of contraction and relaxation processes. Understanding the differences of these muscles from skeletal muscle. Understanding the general theories about aging physiology. Understanding the mechanisms of aging and death and their relationship between apoptosis and oxidant systems.

Basic genetics: The student will be able to: Explain the organization of human genome ,DNA structure,Gene structure, gene families, repetitive DNA sequences, Find out DNA replication ,DNA damage and repair; The nature of mutations . Provide information about principles of recombinant DNA technology Genetic engineering and human genom project Transcription and regulation of gene expression Explain cell cycle, mitosis and Molecular genetics of the cell cycle control systems .Cell cycle regulation and cancer cells, proto-oncogenes, oncogenes tumor suppressor genes and the genetics of cancer Point out the importance of Meiosis and formation of germ cells, genetic recombination Get information about the Molecular and biochemical basis of genetic disorders Treatment of genetic diseases and gene therapy Explain Isolation of chromosomes and Chromosomal abnormalities , Provide information about Mendelian inheritance (definitions), autosomal inheritance Multifactorial inheritance, mitochondrial inheritance, Recessive inheritance, X linked inheritance ,The general properties of genetic disorders Define the concept of Genomic imprinting, uniparental disomy, Give some information about Immunogenetics

Histology: The student will be able to understand what histology and its methods are. They will learn and recognize the microscopical structure of the four basic tissues of the human body. On the next step they will be prepared to identify these tissues in organs and systems of the body. This will help the student to realize how they blend with each other to form the organs, organ systems and the body. As far as embryology is concerned the student will understand the steps in molecular regulation and signaling of the embryonic cells and how they influenced themselves in body formation. They will learn how gametes are formed. They will learn the differentiation and development of the structures during embryonic period. They will understand the formation of gut and the body cavities. They will have an idea about the development and growth of the fetus and the placenta. All through these steps the student will have a chance to learn the congenital abnormalities and their relationships that may occur and understand how prenatal diagnosis is important.

Teaching Lectures and laboratory practices. methods and strategies

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 16/125 Lectures of the Course No Title 1. Digestion of nucleic acids. Metabolism of purine nucleotides 2. Introduction, Gene structure 3. Histology & Its Methods of Study 4. Metabolism of pyrimidine nucleotides 5. Epithelial Tissue I 6. Introduction to Physiology 7. Organization of genomes 8. Epithelial Tissue II 9. Homeostasis 10. Body fluids and body fluid compartmens 11. Epithelial Tissue III 12. Gene families, pseudogenes, repetitive DNA sequences 13. DNA replication 14. DNA synthesis 15. Connective Tissue I 16. DNA damage and repair; The nature of mutations 17. Fluid exchange between intra- and extracellular compartmens 18. Connective Tissue II 19. Connective Tissue III 20. DNA repair and mutations 21. Physical properties of the blood 22. Physiological properties of the cell membrane 23. RNA synthesis 24. Connective Tissue IV 25. Cartilage Posttranscriptional modifications of RNA, RNA-dependent synthesis of nucleic acids.HIV 26. inhibitors 27. Principles of recombinant DNA technology 28. Bone I 29. Biosynthesis of proteins 30. Transport of ions and molecules across the cell membrane 31. Membrane potentials, Genesis of resting membrane potentials 32. Bone II 33. Genetic engineering and human genom project 34. Transcription, control of the gene expression 35. Excitation of the excitable tissues 36. Bone III 37. Regulation of gene expressıon and protein targeting 38. Blood Cells I 39. Blood Cells II 40. Cell cycle, mitosis 41. The cell cycle control system 42. Blood Cells III 43. Hematopoiesis 44. Molecular genetics of the cell cycle control systems 45. Ionic basis of excitation, types of action potentials Cell cycle regulation and cancer cells, proto-oncogenes, oncogenes and tumor 46. suppressor genes 47. Oncogenes, Tumor Supressor Genes and cancer 48. Tumor markers 49. Nervous Tissue I 50. Nervous Tissue II 51. Physiological properties of nerve cells,Classification and function of nerve fibers 52. Intracellular Communication-I 53. Intracellular Communication-II 54. The genetics of cancer

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 17/125 No Title 55. Functional Structure of the Proteins and It‟s Biophysical Spesific Features 56. Meiosis and genetic recombination 57. Nervous Tissue III 58. Nervous Tissue IV 59. Muscle Tissue I 60. Smooth muscle and electrical properties 61. Molecular and biochemical basis of genetic disorders 62. General theories about aging, cellular death and apoptosis 63. Mechanisms of aging, cellular death and apoptosis 64. Ionic mechanisms of the Smooth muscle contraction and relaxation 65. Muscle Tissue II 66. Molecular basis of genetic disorders 67. Treatment of genetic diseases and gene therapy Electrical Properties of the cardiac muscle, cellular and ionic mechanisms of the heart 68. muscle contraction and relaxation Comparition of the cellular, electrical and mechanical properties of the smooth and 69. cardiac muscles with skeletal muscle 70. Muscle Tissue III 71. Mendelian inheritance (definitions), autosomal inheritance 72. Recessive inheritance, X linked inheritance 73. Multifactorial inheritance, mitochondrial inheritance 74. Muscle Tissue IV 75. Introduction to Embryology-Molecular Regulation & Signalling 76. Genomic imprinting, uniparental disomy 77. Gametogenesis I 78. Gametogenesis II 79. Isolation of chromosomes 80. 1st Week of Development Ovulation to implantation 81. 2nd Week of Development (Bilaminar Germ Disc) Thermodynamic Principles and Regulation of Energy Transfer in Living Structures, 82. Biophysical specialities of Usage of Methabolic Energy in Biological Work 83. The methods of isolating chromosomes 84. 3rd Week of Development (Trilaminar Germ Disc) 85. 3rd To 8th Weeks of Development (Embriyonic Period) I 86. 3rd To 8th Weeks of Development (Embriyonic Period) II 87. Irregular Cell Proliferation Mechanisms 88. Chromosomal abnormalities I 89. Chromosomal abnormalities II 90. The general properties of genetic disorders 91. Nanomedicine concept: from laboratory to current practice 92. Fetal Period 93. Immunogenetics 94. Biological Effects of Ionian Radiation 95. Biomechanics 96. Fetal Membranes and Placenta 97. Twins and birth 98. Tracers, radiosensitivity, radiopharmaceuticals and their biological behavior 99. Biophysical approaches in cell cycle and differentiation 100. The general properties of genetic disorders 101. Tracers, Radiosensitivity, Radiopharmaceuticals and Their Biological Behavior 102. Birth Defects and Prenatal Diagnosis 103. Body cavities and serous membranes

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 18/125 Course 1.4: Introduction to Clinical Medicine Chair: Prof. Dr. Hacı Murat Emül, Psychiatry Phone: +902124143000/23013 Secretary: +902124143000/21768 E-mail: [email protected] Vice Chairs: Prof. Dr. Oktay Demirkıran, Anesthesiology and Reanimation Prof. Dr. Suat Hilal Akı, Pathology

Members: Prof. Dr. Ahmet Gökhan Akkan, Pharmacology Prof. Dr. Hrısi Bahar, Microbiology

Semester: 2

Credit of Course: 10

ECTS Credit of Course: 10

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%) Anesthesiology and Reanimation 6 8 10 Child and Adolescent Psychiatry 3 0 3 Pharmacology 20 0 21 Microbiology and Clinical Microbiology 10 2 12 Nuclear Medicine 2 0 2 Pathology 28 8 33 Psychiatry 19 0 19 Total 88 18 100

Course aims and learning outcomes Multidisciplinary course “Introduction to Clinical Medicine” contains, Anesthesiology Course content and Reanima,Pharmacology,Microbiology and Clinical Microbiology,Nuclear Medicine,Pathology,Psychiatry lessons. Pharmacology Course aims 1. Introduction to Pharmacology Teaching the branches and divisions of pharmacology and their role in medical sciences, related terminology and their historical prospective.

2. Pharmacokinetics Learning pharmacokinetic properties of drugs 3. Pharmacodinamics Learning the mechanism of action of drugs and their underlying basic principles, treatment design based on these principles

Microbiology and Clinical Microbiology In this course, it was aimed the students, to learn the theories related wıth microbiology in a level which will constitue a base for their learnings in advanced

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 19/125 classes, to have notion about bacteria, fungi, parasites ,vıruses and prions, to gain proficiency in a level which will serve them for microscobic examination of bacteria cine,

Pathology: Description of factors and morphological features of cell degeneration and cell death, description of features of inflammatory reactions, explanation of tumor- neoplasia concept and their mechanisms, description and explanation of morphological features of hemodynamic disorders and their consequences.

Psychiatry The students throughout this course: They should scrutinize the possible contributions of central nerve system and related biological systems to forming of human behavior Alongside biological developing, they should think about the influences of psychosocial development on the existence of human beings. They should recognize the psychological sub structures and causals of the behavior and attitudes in normal human beings. They should analyze the role of biological and psychic structures in the development of mental illnesses. Alongside psychiatric illnesses, they should handle medical diseases and all patients within all biopsychosocial dimensions. Pharmacology Learning a. Knowledge outcomes Terminologies of pharmacology, drug and medicine The perspective of historical development of pharmacology in the world and in our country Pharmacology and its sub branches Pharmacodynamics, Pharmacokinetics, Pharmacognosy, Pharmacogenetics, Pharmacy, Pharmacotherapy, Clinical pharmacology and Toxicology Source of drugs, natural and synthetic drugs, herbal medicines, chemistry of active drug(substance), pharmaceutical formulation, drug dose and dosage form Pre clinical drug development and stages of drug development (Phase I, II, III, IV), Legislative provisions for drug, and to get knowledge regarding pharmacopoeia.

b. Skills The course is theoretical, knowledge will be applied in clinical practice.

c. Attitute Pharmacology and related concepts are applicable in other fields of medical sciences.

2. Pharmacokinetics: a. Knowledge Introduction to the pharmacokinetic process, stages (absorption, distribution of drug in the organs, process of absorption) Factors affecting the drug absorption ( Cell membrane, tissue cells, biochemical and vascular properties), simple diffusion, active diffusion, facilitated diffusion, to articulate mathematical parameters of digestion and absorption Molecular size and polarity of the active ingredient, effect of dosage form, pre systemic elimination Bioavailability Dosage form and routes of administration of drugs (systemic enteral and parenteral routes, local drug administration), dosage form according to the route of administration Drug distribution, volume of distribution and its mathematical description, factors affecting the tissues and distribution of drug molecules, plasma protein binding,

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 20/125 sequestration and redistribution Biotransformation of Drugs, phase I and phase II biochemical reactions, factors affecting the biotransformation and pharmacogentics. Disposal of drugs and metabolites from the body (excretion), route of excretion like renal excretion, liver and biliary excretion, hepatic and renal clearance, elimination half-life and mathematical calculations, Alternative Therapies in Health and Medicine-(ATHM) (types of dialysis) Study of pharmacokinetic models, Single compartment, two compartment and multiple compartment model, dose-concentration relationship, plasma concentration-time curve after I.V and PO single dose administration, its mathematical calculations, plasma concentration-time curve after repeated drug administration (I.V, PO), concept of steady-state plasma concentration and its mathematical calculations, degree of drug accumulation, loading dose and mathematical expressions will be discussed.

b. Skills Calculation of dosage form according to the pharmacokinetic parameters, time to reach steady-state plasma concentration and therapeutic drug monitoring. c. Attitute Rational use of drugs based on pharmacokinetic parameters.

3. Pharmacodynamics a. Knowledge The principle mechanism involved in drug action (role of receptors and other mechanism) Role of cellular mechanism (endogenous ligand receptors) in drug action, ion channels, genetic determination of these basic elements along with enzymes and carrier molecules, receptor subunits, agonist and antagonist of these substances, physico-chemical structure of the drug and molecule-receptor specificity, role of chemical bonds Postreceptor signal transduction mechanisms: G protein and adenylate cyclase / cAMP system, phospholipase C / inositol phosphate system and calcium ion, guanylate cyclase / cGMP system, phospholipase A2. Examples of drugs that affect these systems. Other mechanism affecting the drugs mode of action Drug effect–(response) measurements, types of pharmacological dose-response (graded, Quantal or all or none response, fixed and variable factors affecting dose response), dose-response curves and related mathematical considerations, theoretical approach to drug receptor interaction and its mathematical expressions, factors modifying drug action (body weight and volume, age, gender, organ diseases and physiological conditions that affect the dynamics and kinetics of a drug, time and route of administration of the drug, social and geographical environment and dietary patterns of the person, genetic factors, biological variability, change in drug response after continuous use, tolerance, tachyphylaxis, desensitization, combination of drugs and the placebo effect) and compliance. Pharmacokinetic and pharmacodynamic interactions of combined drug therapy, types of pharmacodynamics interactions (types of antagonism and agonistic interactions). Demonstration of dose-response curves and mathematical expression of these interactions with specific examples. Types of pharmacokinetic interaction (absorption, distribution and protein binding, metabolism and excretion with related interactions) along with specific examples. Effect of the drug according to the time period, response-time graph

b. Skills Drug therapy can be selected according to patient‟s pathology with knowledge about mechanism of drug action and change in it.

c. Attitute Rational use drug therapy based on the pharmacodynamic principles Microbiology and Clinical Microbiology At the end of this course, the students can

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 21/125 explain the basic theories related with microbiology. They can discuss the general characteristics of bacteria, fungi, parasites, virus and prions.They can examine bacteria in microscope preparing a slide and they can realise the importance of microorganisms and microscope .

Pathology Knowledge Define and explain of the types of cell injury. Identify and categorize the adaptive changes. Explain of cell aging. Explain the etiology and mechanisms of inflammation. Categorize the pathogenesis and episods of inflammation. Describe the types and morphology of inflammation. Explain and categorize the types, circumstances and affecting factors of wound healing. Describe neoplasia and designate neoplasia according to the tissue type orginating from. State differential diagnostic features of benign and malignant tumors. Explain mechanisms of carcinogenesis. Explain tumor immunity. Explain mechanisms and clinical reflections of edema and hydration states. Explain reasons, morphological features and clinical reflections of hyperemia and hemorrhage. Categorize and explain mechanisms, types, consequences and complications of thrombus and embolism. Explain mechanisms, morphological types and styles of repair of ischemia and infarction. Define and explain reasons, types, mechanisms, morphological features and clinical reflections of shock. Categorize and explain reasons, types, mechanisms, clical and morphological fetures of hypertension.

Ability Define cellular mechanisms of pathological basis of diseases and categorize morphlogical and clinical findings of inflammatory lesions and hemodynamic disorders. Lectures and laboratory practices. Teaching methods and strategies

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 22/125 Lectures of the Course No Title 1. Introduction to pharmacology (1/2) 2. Introduction to Pathology, Definitions 3. Introduction to C.N.S: psychology and behavior theories. neurons and synapses 4. Introduction to Medical Microbiology, 5. Cell injury and the mechanisms 6. Introduction to C.N.S: cognitive functions 7. Cell injury and the mechanisms II 8. Introduction to pharmacology (2/2) 9. Cellular response to injury: Degeneration, necrosis, apoptosis 10. Perception 11. What is first aid? 12. Routes of Practice of Drugs (1/2) 13. Routes of Practice of Drugs (2/2) 14. Cellular adaptation: Hyperplasia, hypertrophia 15. Attention and voliton 16. Microbial Taxononomy Eucaryotes and Procaryotes and classification of bacteria 17. Cellular adaptation: Atrophia and metaplasia 18. Motivation and Drive 19. Pharmacokinetics (1/4) 20. Intracellular accumulations and pathologic calcifications 21. Defense mechanisms and theories 22. Evaluation of patient and vital signs 23. Body fluids, edema, dehidratation 24. Pharmacokinetics (2/4) 25. Pharmacokinetics (3/4) 26. Genetics in psychiatry 27. Psychoneuroendocrinology 28. Bacterial morphology, physiology and metabolism 29. Hyperemia, congestion, hemorrhage 30. Pharmacokinetics (4/4) 31. Hemostasis and thrombosis 32. Memory 33. Mechanisms of Drug Actions (1/2) 34. Intelligence and related psychopathology 35. Introduction to Bacterial genetics 36. Basic life support I (Automated external defibrilator) 37. Thromboembolism 38. Ischemia and infarct 39. Shock, Hypertension 40. The concept of inflammation, inflammatory cells and elements 41. Personality Disorder 42. Mechanisms of Drug Actions (2/2) 43. Normal Microbial flora 44. Chemical mediators of of inflammation 45. Stres reaction and coping mechanisms 46. Drug Receptors, Signal Transduction and Drug-Receptor İnteraction (1/2) 47. Pathogenesis of acute inflammation 48. Basic life support II - Airway Obstruction, Recovery Position 49. General Properties of Viruses and prions 50. Leukocyte extravasation, adhesion and transmigration; chemotaxis and phagocytosis 51. Addiction 52. Drug Receptors, Signal Transduction and Drug-Receptor İnteraction (2/2) 53. Chronic inflammation, angiogenesis, fibrosis 54. Emotions and feelings 55. Dose (Concentration)-Effect Relationship (1/2)

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 23/125 No Title 56. Healing of the inflammation: Regeneration and reperation 57. Neurotransmitters in Psychiatry 58. Behavioral and Emotional Problems in Children 59. Introduction to neoplasia, definition nomenclature of tumor 60. Paediatric Basic Life Support 61. General Properties of Fungi 62. Properties of benign and malign neoplasias, epithelial and nonepithelial tumors (1/3) 63. Dose (Concentration)-Effect Relationship (2/2) 64. Properties of benign and malign neoplasias, epithelial and nonepithelial tumors (2/3) 65. Adolescent Psycology 66. Factors That Modify Drug Actions and Drug İnteractions (1/2) 67. Pschosocial and physical development theories 68. Factors That Modify Drug Actions and Drug İnteractions (2/2) 69. Properties of benign and malign neoplasias, epithelial and nonepithelial tumors (3/3) 70. Simple and conditioned reflexes and behaviour 71. Chemical and viral carcinogenesis 72. Bleeding management and Shock Roles of oncogenes, tumour supressor genes, and genes that regulate DNA repair at 73. cancer generation; steps of cancer generation (1/2) 74. General properties of protozoa and helmints 75. Basic Physics in Nuclear Medicine and Instrumentation 76. Perception Roles of oncogenes, tumour supressor genes, and genes that regulate DNA repair at 77. cancer generation; steps of cancer generation (2/2) 78. Radiopharmacy and Tracer Kinetics 79. Adverse drug reactions (drug toxicology) (1/2) 80. Psycholgy in late life Tumor kinetics and progression; pathogenesis of invasion and metastasis; angiogenesis 81. (1/2) 82. General Properties of Arthropods Tumor kinetics and progression; pathogenesis of invasion and metastasis; angiogenesis 83. (2/2) 84. Developmental Pathologies in Children 85. Adverse drug reactions (drug toxicology) (2/2) 86. Environment and microorganisms 87. Pharmacogenetics (1/2) 88. Pharmacogenetics (2/2)

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 24/125 2nd Year Courses Course 2.1: Locomotor System Chair: Prof. Dr. Güler Kahraman Yıldırım, Anatomy Phone: +902124143000/22496 Secretary: +902124143000/21563 E-mail: [email protected] Vice Chairs: Prof. Dr. Kenan Akgün, Physical Medicine and Rehabilitation Prof. Dr. Nuran Darıyerli Toktamış, Physiology Members: Prof. Dr. Tania Marur, Anatomy Assoc. Prof. Dr. Mehmet Can Ünlü, Orthopedics

Semester: 3

Credit of Course: 8

ECTS Credit of Course: 8

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%) Anatomy 21 14 42 Biochemistry 3 0 4 Pediatrics 3 0 4 Infectious Diseases 2 0 3 Pharmacology 5 0 7 Physical Medicine and Rehabilitation 3 0 5 Physiology 5 2 9 Histology and Embryology 3 0 5 Internal Medicine 3 0 5 Nuclear Medicine 1 0 1 Orthopedics and Traumatology 3 0 5 Pathology 5 2 9 Radiodiagnostics 1 0 1 Total 58 18 100

Course aims and learning outcomes Course content Locomotor system course gives information about the normal structure, development and functions of bones, joints and muscles, system related diseases, (etiology,symptoms, basic clinical and laboratory findings, diagnostic methods) and drugs used for system related diseases.

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 25/125 Course aims At the end of the course; the students should learn function, structure, development, and physiopathology of Locomotor System ( bones, joints, muscles) and basic clinical and laboratory diagnostic methods, drugs used for system related diseases. Learning By the end of the Locomotor System course the student should be able to: outcomes 1. Describe anatomical structures, 2. Describe development and embryonic origins, 3. Describe histological structures, 4. Describe functional mechanisms, 5. Describe Etiopathogenesis, clinical findings, 6. Describe radiological images, 7. Describe terapoetic methods, 8. Describe mechanism of action and effects of system related drugs of the Locomotor System. Teaching Lectures, laboratory practices, homework, interactive presentation, demonstration, methods and strategies

Lectures of the Course No Title 1. Locomotor System, Introduction 2. Bones of Upper Limb 3. Biochemistry of bone 4. Bones of Lower Limb 5. Bones of Axial Skeleton, Vertebra, Ribs, Sternum 6. Biochemistry of connective tissue 7. Histology of Bone, Cartilage and Muscle 8. Development of the Skeletal System 9. Cranium, Neurocranium 10. Fracture and healing of fracture, bone infection 11. Physiology of Bone 12. Viscerocranium 13. Head as a whole I 14. Bone diseases due to metabolic dysfunction 15. Head as a whole II 16. Bone scintigraphy and bone densitometry 17. Osteomyelitis 18. Bone lesions of unknown origin / tumour like lesions , Bone tumors 1 19. Joints, Introduction 20. Joints of Upper limbs 21. Bone lesions of unknown origin / tumour like lesions , Bone tumors 2 22. Joints of Lower Limb I 23. Joints of Lower Limb II 24. Septic arthritis 25. Joint diseases and soft tissue tumors 26. Joints of Axial Skeleton 27. Peripheral Nervous System (1/2) 28. Peripheral Nervous System (2/2) 29. Muscles, Introduction 30. Muscles of Head and Neck 31. Biochemistry of muscle 32. Development of the Muscle Tissue 33. Neuromuscular transmission 34. Muscles of Upper Limb 35. Muscles of Lower Limb 36. Muscles of Trunk (1/2)

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 26/125 No Title 37. Muscles of Trunk (2/2) 38. Physiological anatomy and electrical properties of skeletal muscle 39. General aproach to Rheumatic Diseases Introduction to muskuloskeletal system radiology and the radiologic anatomy of 40. extremities 41. Physical Examination of the Locomotor System 42. Introduction to the Biomechanics of the Musculoskeletal System Mechanism of contraction and relaxation, Molecular Characteristics of theContractile 43. Filaments 44. Skeletal-Muscle EnergyMetabolism,Motor unit, Mechanics of Single-FiberContraction 45. Physical Examination of the Locomotor System in childhood 46. Drugs Effecting Neuromuscular Transmission 47. NSAIDs (1/2) 48. NSAIDs (2/2) 49. Epidemiology of Rheumatic Diseases 50. Laboratory Evaluation of Rheumatic Diseases 51. The Evaluation of Locomotor System Pains 52. Arthritis in Childhood I 53. Arthritis in Childhood II 54. General Approach to the Fractures and Dislocations I 55. Physical Medicine and Rehabilitation in Locomotor System 56. General Approach to the Fractures and Dislocations II 57. Skeletal muscle relaxants and spasmolytics (1/2) 58. Skeletal muscle relaxants and spasmolytics (2/2)

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 27/125 Course 2.2: Cardiovascular System Chair: Prof. Dr. Gülderen Şahin, Physiology Phone: +902124143000/21614-22572 Secretary: +902124143000/21572 E-mail: [email protected] Vice Chairs: Prof. Dr. Zeki Öngen, Cardiology Prof. Dr. Ercan Tanyeli, Anatomy Members: Prof. Dr. Funda Öztunç, Pediatrics Prof. Dr. Öner Süzer, Pharmacology

Semester: 3

Credit of Course: 14

ECTS Credit of Course: 14

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%) Anatomy 13 14 16 Biochemistry 2 2 2 Pediatrics 7 0 6 Infectious Diseases 1 0 1 Pharmacology 26 0 20 Physiology 22 8 20 Histology and Embryology 8 2 7 Internal Medicine 1 0 1 Cardiovascular Surgery 2 0 2 Cardiology 22 0 17 Nuclear Medicine 2 0 2 Pathology 6 4 6 Total 112 30 100

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 28/125 Course aims and learning outcomes Course content Cardiovascular System course provides information about the normal structure, development and functions, system-related diseases, etiology, symptoms, basic clinical and laboratory findings, diagnostic methods for Cardiovascular System and drugs used for related diseases. Course aims Teaching function, structure, development and physiopathology of Cardiovascular System, and basic clinical and laboratory diagnostic methods, drugs used for related diseases. Learning By the end of Cardiovascular System course the students should be able to: outcomes Describe anatomical structures, Describe development and embryonic origins of cardiovascular system Describe histological structure, Describe Regulatory Mechanism of Cardiovascular System Describe etiopatogenesis, symptoms, clinical and laboratory findings of cardiovascular system diseases. Describe diagnostic imaging modalities for investigation of the cardiovascular system List the treatment options for cardiovascular system diseases. Describe the effects, mechanisms of action, pharmacokinetics, side effects and interactions of the drugs used in the treatment of diseases of the cardiovascular system Describe pharmacology of the autonomic nervous system and autocoids Teaching Lectures, clinical and laboratories, homework, demonstration. methods and strategies

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 29/125 Lectures of the Course No Title 1. Introduction to Systemic Anatomy, Circulatory System 2. General Anatomy of Autonomic Nervous System 3. Morphology of Heart 4. Vessels of Heart 5. Autonomic nervous system (1/2) 6. Autonomic nervous system (2/2) 7. Introduction to autonomic nerve system and neurotransmission (1/2) 8. Introduction to autonomic nerve system and neurotransmission (2/2) 9. Nerves of Heart and Pericardium 10. Arteries: Head-Neck and Upper Limb Artreries 11. Electrical activity of the heart, spread of excitation 12. Parasympathomimetics and cholinesterase inhibitors and reactivators (1/2) 13. Arteries of Thorax and Abdomen 14. Arteries of Pelvis and Lower Limb 15. Sinus rhythm, mechanism of abnormal rhythm production 16. Parasympathomimetics and cholinesterase inhibitors and reactivators (2/2) 17. Parasympatholytics and ganglion blockers (1/2) 18. Parasympatholytics and ganglion blockers (2/2) 19. Veins of Head-Neck and Upper Limb 20. Sympathomimetic drugs (1/2) 21. Sympathomimetic drugs (2/2) 22. Sympatholytic drugs: Alpha adrenoceptor blockers (1/2) 23. Sympatholytic drugs: Alpha adrenoceptor blockers (2/2) 24. Sympatholytic drugs: Beta adrenoceptor blockers (1/2) 25. Sympatholytic drugs: Beta adrenoceptor blockers (2/2) 26. Veins of Thorax, Abdomen, Pelvis and Lower Limb 27. Circulatory System, Adult and Fetal Circulation 28. Antiarrhythmics (1/2) 29. Antiarrhythmics (2/2) 30. Lymphatic Organs and Structures, Lymphatic Circulation 31. Spread of cardiac excitation through atria and ventricle muscle 32. Circulatory System Histology (1/4) 33. Circulatory System Histology (2/4) 34. Mechanical events of the heart, cardiac cycle 35. Pressure and volume changes in the atria and ventricles, Heart sounds 36. Factors controling cardiac output, stroke work and O2 consumption of the heart 37. Electrocardiogram (1/2): bipolar limb leads, cardiac vector 38. Lymphatic Vessels, Regional Lymph Nodes 39. Electrocardiogram (2/2): unipolar limb leads, cardiac axis 40. Physiology of the circulation: Hemodynamics of circulation 41. Arterial and arteriolar circulation, arterial pressure and arterial pulse 42. Circulatory System Histology (3/4) 43. Circulatory System Histology (4/4) 44. Histamine agonist and antagonists 45. Serotonine agonist and antagonists 46. Capillary circulation, Lymphatic system and edema formation 47. Symptoms in cardiology (1/2) 48. Cardiovascular System Embryology (1/4) 49. Cardiovascular System Embryology (2/4) 50. Angiotensins, Kinins, Nitric oxide 51. Symptoms in cardiology (2/2) 52. Cardiovascular System Examination 53. Cynosis 54. Eicosanoids (1/2) 55. Eicosanoids (2/2)

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 30/125 No Title 56. Edema 57. Edema 58. Venous circulation and factors effecting venous circulation 59. Examination of arterial and venous disease 60. Local control of blood flow by tissues 61. Neural regulation of the circulation and rapid control of arterial pressure 62. Inspection and palpation of precordium 63. Auscultation of the heart (1/2) 64. Auscultation of the heart (2/2) 65. Long -term regulation of arterial pressure, regulation of blood pressure during exercise 66. Cyspnea-Chest Pain 67. Introduction to cardiac radiology 68. Congenital acyanotic heart defect 69. Valvular heart disease 70. Infective endocarditis Etiopathogenesis and laboratory findings 71. Congenital Syanotic Heart Disease 72. Cardiovascular System Embryology (3/4) 73. Cardiovascular System Embryology (4/4) 74. Basics of electrocardiogram (1/2) 75. Basics of electrocardiogram (2/2) 76. The ECG of conduction disturbances 77. Congenital heart disease 78. Infective endocarditis and valvular heart disease 79. Coronary circulation 80. Specific circulation (1/2) 81. Infective endocarditis 82. Measurement of blood pressure and concept of hypertension (1/2) 83. Measurement of blood pressure and concept of hypertension (1/2) 84. Antihypertensives (1/2) 85. Atherosclerosis and risk factors 86. Hypertension in children 87. The ECG of supraventricular arrhythmias 88. Antihypertensives (2/2) 89. Specific circulation (2/2) 90. The ECG of ventricular arrhythmias 91. Biochemistry of endothelial cells 92. Endothel function, atherosclerosis, types of anevrisms 93. Chronic ischemic heart disease 94. Physiologic mechanisms of shock 95. Hypolipidemic drugs 96. Clinical laboratory tests in cardiac disease 97. Acute coronary syndromes 98. Antianginals and peripheral vasodilators (1/2) 99. Antianginals and peripheral vasodilators (2/2) 100. Pathogenesis of ischemic heart disease and Myocardial infarction 101. Myocard perfusion scintigraphy 102. Circulatory parameters in Heart failure 103. Physiopathology of heart failure 104. Heart failure 105. Shock 106. Treatment of heart failure 107. Cardiomyopathies 108. Myocardial diseases, cardiomyopathies, myocarditis, pericarditis 109. Lymphoscintigraphy and Gamma Probe applications 110. Pericard diseases 111. Introduction to cardiovascular surgery

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 31/125 Course 2.3: Respiratory System Chair: Prof. Dr. Nermin Yelmen, Physiology Phone: +902124143000/21612 Secretary: +902124143000/21572 E-mail: [email protected] Vice Chairs: Prof. Dr. Gül Öngen, Pulmonary Medicine Prof. Dr. Ali İhsan Soyluoğlu, Anatomy Members: Prof. Dr. Büge Öz, Pathology Prof. Dr. Akif Turna, Thoracic Surgery

Semester: 3

Credit of Course: 8

ECTS Credit of Course: 8

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%) Anatomy 4 4 10 Pediatrics 2 0 3 Infectious Diseases 1 0 2 Pharmacology 6 0 10 Physiology 11 4 21 Thoracic Surgery 1 0 2 Pulmonary Medicine 14 0 22 Histology and Embryology 4 2 8 Otorhinolaryngology 1 0 2 Nuclear Medicine 1 0 2 Pathology 8 2 15 Radiodiagnostics 2 0 3 Toplam / Total 55 12 100

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 32/125 Course aims and learning outcomes Course content Respiratory System course provides knowledge about the normal structure, development and functions, system-related diseases, etiology, symptoms, basic clinical and laboratory findings, diagnostic methods for Respiratory System and drugs used for related diseases. Course aims At the end of the Course students should gain knowledge of the function, structure, development and physiopathology of Respiratory System, and basic clinical and laboratory diagnostic methods, drugs used for related diseases. Learning At the end of Respiratory System course the students should be able to: outcomes 1. Describe anatomical structures, 2. Describe development and embryonic origins of respiratory system 3. Describe histological structure, 4. Describe functions of respiratory system and regulation of respiration 5. List the normal values of the arterial blood gases 6. Describe lung volumes and capacities and evaluate them 7. Describe etiopatogenesis, symptoms, clinical and laboratory findings of respiratory system disorders. 8. Describe diagnostic imaging modalities for investigation of the respiratory system 9. List the treatment options for diseases of the respiratory system. 10. Describe the effects, mechanisms of action, pharmacokinetics, side effects and interactions of the drugs used in the treatment of diseases of the respiratory system. Teaching Lectures, clinical and laboratory practices, homework, demonstration. methods and strategies

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 33/125 Lectures of the Course No Title 1. Respiratory System: Nose, Paranasal Sinuses 2. Physiology of Respiratory System, Mechanics of breathing 3. The Respiratory System, Conducting portion 4. The Respiratory System , Larenx and Trachea Histology 5. Larynx, Trachea and Bronchi 6. Inspiratory and expiratory mechanisms 7. Pressure-Volume changing, compliance 8. Histology of the alveoli and the Lung 9. Lungs and Pleura, Mediastinum 10. Lung volume and capacities 11. Respiratory System Development 12. Clinical Anatomy of Respiratory System 13. The radiologic anatomy of Respiratory System-I 14. Ventilation-perfusion relationship: V/P ratio 15. The radiologic anatomy of Respiratory System-II 16. Lung function tests: Diffusion capacity 17. History and Symptoms in Pulmonary Diseases (dyspnea, chest pain) 18. Cellular values of respiratory system 19. Gases Transport in the Blood, Oxygen Carriage 20. Examination of the chest (pulmonary function tests) 21. Pathology of upper airways 22. Anamnesis in Upper Respiratory Tract Diseases 23. Physical examination of thorax and lung (inspection, palpation) 24. Carbondioxide transport and Respiratory quotient 25. Atelectasis, diseases of vascular origin in lung 26. Chemical regulation and respiratory regulation in sleep 27. Drugs used in Upper Respiratory Tract Diseases 28. Physical examination of thorax and lung (percussion oscultation) 29. Pathology of Obstructive pulmonary diseases 30. History and Symptoms in Pulmonary Diseases (cough, sputum, hemoptysis) 31. Obstructive pulmonary diseases 32. Respiratory physiology at high and low pressures 33. Bronchodilators ve other antiastmatic drugs 34. Development of respiratory system in children 35. Examination of the chest (radiology) 36. Restrictive pulmonary diseases 37. Cough, Stridor, wheezing 38. Other Laboratory methods 39. Approach to respiratory system infection in adults 40. Bronchodilators ve other antiastmatic drugs 41. Pulmonary infections 42. Antitussives, expectorants, mucolytics, surfactants 43. Lung tumors 44. Pneumonia 45. Drugs used in Lung Cancer 46. Lung tumors II, plevral diseases 47. Lung cancer 48. Symptoms and signs in pulmonary surgery 49. Nuclear Medicine in Respiratory System 50. Pulmonary tuberculosis 51. Drugs used in Lung Tuberculosis 52. Environmental Physiology 53. Tuberculosis 54. Smoking and enviromental lung diseases (1/2) 55. Smoking and enviromental lung diseases (2/2)

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 34/125 Course 2.4: Hematopoietic System, Immunology, Microbiology Chair: Prof. Dr. Gökhan Aygün, Microbiology and Clinical Microbiology Phone: +902124143000/22754 Secretary: +902124143000/21647 E-mail: [email protected] Vice Chairs: Prof. Dr. Teoman Soysal, Internal Medicine Prof. Dr. Yıldız Camcıoğlu, Pediatrics Üyeler (Members)*: Prof. Dr. Aydın Barlas, Pharmacology Prof. Dr. Gönül Şimşek, Physiology

Semester: 4

Credit of Course: 16

ECTS Credit of Course: 16

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%) Biochemistry 6 2 5 Pediatrics 6 0 5 Pharmacology 12 0 8 Physiology 9 4 8 General Surgery 2 0 2 Histology and Embryology 3 2 3 Internal Medicine 20 0 13 Microbiology and Clinical Microbiology 47 6 35 Nuclear Medicine 1 0 1 Pathology 9 4 8 Medical Education 0 36 12 Total 115 54 100

Course aims and learning outcomes Course content Hematopoietic System, Immunology, Microbiology course provides knowledge and skills about the normal structure, development and functions, system-related diseases, etiology, symptoms, basic clinical and laboratory findings, diagnostic methods for Hematopoietic System, Immunology, Microbiology and drugs used for related diseases. Also this course covers a clinical skills module (patient encounter and communication skills, ethics, patient transportation, basic clinical procedures, hand hygiene, the prevention of nosocomial infections and, CPR)

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 35/125 Course aims By the end of the this Course students should learn function, structure, development and physiopathology of Hematopoietic System, Immunology, Microbiology, and basic clinical and laboratory diagnostic methods, drugs used for related diseases. Learning By the end of the Hematopoietic System, Immunology, Microbiology course the outcomes students should be able to: 1. Describe basic subjects of microbiology, characteristics of viruses 2. Describe the diseases of these systems 3. Describe the etiopatogenesis of hematopoietic and immunologic systems diseases. 4. Describe the laboratory findings of hematopoietic and immunologic systems diseases. 5. List the treatment options for hematopoietic and immunologic systems diseases 6. Describe the factors, diagnosis and treatment options of viral and fungal infections 7. Be aware of the importance of professional and ethical behaviour in the act of medical care

Teaching Lectures, laboratory practices, basic clinical skills training, homework methods and strategies

Lectures of the Course No Title 1. Organs and tissues of immune system -I 2. Organs and tissues of immune system -II 3. Organs and tissues of immune system -III 4. Naturel immune system 5. Introduction to clinical microbiology 6. Phagocytes and inflammation 7. Cell structure and classification of medically important bacteria 8. Bacterial pathogenesis 9. Bacterial genetics, diagnosis, cultivation 10. Endotoxins and exotoxins 11. Sterilisation, Disinfection, and Antisepsis (1/2) 12. Sterilisation, Disinfection, and Antisepsis (2/2) 13. Colonisation, infection and infectious diseases 14. Innate immune response 15. Cell mediated immunity 16. Introduction to medical mycology 17. Dermatophytes, other superficial mycoses, subcutaneous mycoses 18. Mechanisms of specific host defense 19. Candida, Cryptococcus neoformans and other yeasts 20. Complement System 21. Antigens and antigen recognition 22. Humoral immunity 23. Dimorphic fungi 24. Opportunistic mycoses and Pneumocystis 25. Mycotoxins 26. Antifungal chemotherapy 27. Immun receptors and signal transduction 28. Acquired immune system 29. Cytokines and interferons 30. Active and passive immunity 31. Immunity to fungi 32. Antifungals

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 36/125 No Title 33. Classification, cultivation and identification of viruses 34. Prevention and treatment of viral infections 35. Immunotolerance 36. Dysenfectans and antiseptics 37. Herpesviruses 1 38. Herpesviruses 2 39. Active Immunization 40. Assessment of functional immune responses 41. Adenoviruses and parvoviruses 42. Poxviruses 43. Prions 44. Hepatitis viruses 1 45. Primary immune deficiencies 46. Laboratory methods in immunology -1 47. Laboratory methods in immunology -2 48. Autoimmunity 49. Autoimmune diseases 50. Transplantation immunology 51. Hepatitis viruses 2 52. Hepatitis viruses 3 53. Picornaviruses 54. Papillomaviruses and polyomaviruses 55. Basic principles of transplantation surgery 56. Paramyxoviruses and Rubella virus 57. Orthomyxoviruses and coronaviruses 58. Rhabdoviruses 59. Arboviruses 60. Retroviruses 1/2 61. Retroviruses 2/2 62. Arenaviruses, Hantaviruses and filoviruses 63. Human Cancer Viruses 64. Antiviral drugs 65. Immunopharmacology 66. Microorganisms and autoimmunity 67. Viral pathogenesis and immunology of viral infections 68. Biochemistry of red blood cells and white blood cells 69. History taking characteristics in Hematopoietic System Disorders 70. Physical Examination characteristics in Hematopoietic System Disorders 71. Hypersensitivity Type III, IV 72. Synthesis of heme and porphyrias 73. Peripheral blood and bone marrow examination 74. Hematopoetic System 75. Hematopoesis –I: mechanisms of Eritropoiesis 76. Hematopoesis –II: mechanisms of Leukopoiesis and types of leukocytes 77. Catabolism of heme and hyperbilirubinemia 78. Anemia in children 79. Hematopoesis –III: mechanisms of thrombopoiesis 80. Iron metabolism and hemoglobin 81. Hemostasis,Coagulation and fibrinolysis mechanisms 82. The blood groups 83. Classification of anemias in adults 84. Biochemical evaluation of anemias 85. Iron deficiency anemia 86. Antianemic drugs Introduction to chronic myeloproliferative disorders Polystemia vera and essential 87. thrombocytemia 88. Laboratory diagnosis in disorders of hemoglobin metabolism

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 37/125 No Title 89. General principles of hemolytic anemias 90. Hemostatic mechanisms and routine tests for hemorrhagic diathesis-2 91. Hemostatic mechanisms and routine tests for hemorrhagic diathesis-1 92. Haemostatic drugs 93. Acquired hemolytic anemias 94. Bleeding tendency 95. Acute leukemias 96. Anti-thrombocyte, anticoagulant, thrombolytic drugs (1/2) 97. Anti-thrombocyte, anticoagulant, thrombolytic drugs (2/2) 98. Hereditary hemolytic anemias 99. Hodgkin lymphoma 100. Aplastic anemia and myelodysplastic syndrome 101. Surgical bleeding and hemostasis 102. Megaloblastic anemias 103. Non Hodgkin lymphoma 104. Pancytopenias and aplastic anemia 105. Chronic myeloproliferative diseases 106. Chronic myeloid leukemia, idiopatic myelofibrosis 107. Antineoplastics (1/2) 108. Antineoplastics (2/2) 109. Clinical characteristics of lymphomas 110. Pathology of the diseases of spleen 111. Lymphadenopathies 112. PET scintigraphy in Hematologic Malignancies 113. Plasma cell dyscrasias 114. Splenomegaly 115. Stem cell concept and its applications

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 38/125 Course 2.5: Gastrointestinal System Chair: Prof. Dr. Arzu Seven, Biochemistry Phone: +902124143000/21478 Secretary: +902124143000/21514 E-mail: [email protected] Vice Chairs: Prof. Dr. Serdar Yüceyar, General Surgery Prof. Dr. Ahmet Merih Dobrucalı, Internal Medicine Members: Prof. Dr. Gülderen Şahin, Physiology Prof. Dr. Ayşe Derya Ertem, Anatomy

Semester: 4

Credit of Course: 14

ECTS Credit of Course: 14

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%) Anatomy 8 8 8 Biochemistry 25 10 21 Pediatric Surgery 2 0 1 Pediatrics 8 0 5 Infectious Diseases 2 0 1 Pharmacology 4 0 3 Physiology 14 2 10 General Surgery 20 0 14 Histology and Embryology 8 8 8 Internal Medicine 22 0 15 Nuclear Medicine 1 0 1 Pathology 10 4 8 Radiodiagnostics 1 0 1 Medical Education 0 10 4 Total 125 42 100

Course aims and learning outcomes Course content Gastrointestinal System course provides knowledge and skills about the normal structure, development and functions, system-related diseases, etiology, symptoms, basic clinical and laboratory findings, diagnostic methods for Gastrointestinal System and drugs used for related diseases. Course aims Teaching function, structure, development and physiopathology of Gastrointestinal System, and basic clinical and laboratory diagnostic methods, drugs used for related diseases.

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 39/125 Learning By the end of gastrointestinal system course the students should be able to: outcomes Describe anatomical structures of the gastrointestinal system, Describe development and embryonic origins of the gastrointestinal system, Describe histological structure, Describe function mechanisms. Describe etiopatogenesis, symptoms, clinical and laboratory findings of gastrointestinal system diseases. Describe diagnostic imaging modalities for investigation of the gastrointestinal system List the treatment options for gastrointestinal system diseases. Describe the effects, mechanisms of action, pharmacokinetics, side effects and interactions of the drugs used in the treatment of diseases of the gastrointestinal system Teaching Lectures, laboratory practices, homework, demonstration methods and strategies

Lectures of the Course No Title 1. Digestion and absorption of carbohydrates 2. Glycolysis 3. Digestive System Oral cavity, Tongue 4. Digestive System Pharynx and Teeth 5. The citric acid cycle 6. Metabolism of glycogen 7. Digestive System Esophagus and Stomach 8. Digestive System: Introduction, Mouth 9. Gluconeogenesis and control of blood glucose 10. The pentose phosphate pathway and other pathways of hexose metabolism 11. Digestive System Small and Large Intestine 12. Disorders of carbohydrate metabolism 13. Digestion and absorption of lipids 14. Pharynx and Esophagus 15. Digestive System Accessory glands-I Salivary Glands, Pancreas 16. Organs Associated with Digestive Tract: Salivary Glands and Pancreas 17. Biosynthesis of fatty acids 18. Oxidation of fatty acids and.Ketogenesis 19. Neural control of gastrointestinal function,enteric nervous system 20. Mechanical and chemical digestion in the mouth 21. Metabolism osf acyl Glycerols,sfingolipids and eicozinoids 22. Lipid transport and storage Inflammation and neoplastic lesions of oral cavity and salivary glands,anatomic,motor 23. and inflammatory disorders of esophagus 24. Saliva secretion and function 25. Digestive bladder system accessory glands II liver 26. Cholesterol synthesis, transport and excretion 27. Disorders of lipid metabolism 28. Stomach 29. Digestion of dietary proteins 30. Amino acid transport and associated hereditary disorders 31. Mechanism of swallowing and functions of esophagus 32. Basic rules for stomach motility 33. Catabolism of proteins and of amino acid nitrogen 34. Catabolism of proteins and of amino acid nitrogen 35. Organs Associated with Digestive Tract: Liver and Biliary Ducts 36. Digestive System Development-I

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 40/125 No Title Catabolism of the carbon skeletons of amino acids. Biosynthesis of nonessential amino 37. acids Conversion of amino acids to specialized products. Hereditary disorders of amino acid 38. metabolism 39. Mechanism and regulation of salivation in stomach 40. Inhibition of gastric secretion by other post-stomach factors 41. Laboratory diagnosis in liver diseases 42. Laboratory diagnosis in liver diseases 43. Small and Large Intestine 44. Digestive System Development-II 45. Biochemical evaluation of gastrointestinal dysfunctions 46. Biochemical evaluation of pancreatic disorders 47. Role of pancreas in digestion and regulation of salivation 48. Production of bile and its role in digestion 49. Intestinal motility and secretions 50. Mechanism of regulation of intestinal motility and secretion 51. Peritoneum 52. Topographical Anatomy of Abdomen 53. Gastrointestinal Development 54. Nuclear Medicine in Gastrointestinal and Hepatobiliary System 55. History and physical examination in gastrointestinal system 56. History taking characteristics in gastrointestinal System Disorders 57. Vomiting 58. Radiologic examination and anatomy of the abdomen 59. Surgical symptomatology and diagnosis in diseases of gastrointestinal system 60. Physical examination of the abdomen 61. Abdominal Pain 62. Surgical symptomatology and diagnosis of liver and biliary tract diseases 63. Abdominal pain 64. Diarrhea Constipation 65. Vomiting and gastrointestinal bleeding in childhood 66. Acute abdomen (symptomatology and diagnosis) 67. Dsyphagia 68. Abdominal and Lymphois System 69. Emetics, antiemetics, prokinetics 70. Acute appendicitis (symptomatology and diagnosis) 71. Gastroesophageal reflux disease 72. Icterus 73. Abdominal pain in childhood 74. Gastrointestinal bleeding in surgery 75. Gastritis, H pylori and related diseases 76. Abdominal masses 77. Intestinal obstruction 78. Peptic ulcer disease 79. Hepatomegaly - Ascites 80. Diarrhea, constipation and meteorism 81. Drugs to treat peptic ulcer 82. Metabolic homeostasis in fasting and fed state 83. Splenomegaly 84. Benign and malignant diseases of anus and perianal region 85. Acute cholecystitis (symptomatology and diagnosis) 86. Malabsorption: Symptoms and classification 87. Infectious diseases of small intestine and colon 88. Pathology of esafagus diseases 89. Pathology of stomach diseases 90. Inflammatory bowel disease: Ethiopathogenesis, and clinical presentation 91. Hernias

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 41/125 No Title 92. Colon motility, digestion in colon, and defecation 93. Acute pancreatitis (symptomatology and diagnosis) 94. Gastrointestinal diverticular disease 95. Bile Stones; Ethiopathogenesis, clinical presentation andlaboratory findings 96. Surgical equipments (drains, catheters, suture materials) 97. Digestans, choletics, cholagogues, cholelithics, other drugs effecting on GIS 98. Cholestasis and cholestatic liver disease Basic mechanisms of absorbtion; transport and storage of absorbed carbonhyrates, 99. lipids and proteins 100. Chronic pancreatitis 101. Stomach tumors 102. Viral hepatitis 103. Basic mechanism of absorption,transport and storage of electrolytes and vitamins 104. Medical approach to gastrointestinla bleeding 105. GI symptoms in systemic diseases and systemic findings in GI diseases 106. Idiopathic inflammatory bowel diseases, vascular Disorders of bowel 107. Tumors of small and large bowels and appendix 108. History taking and physical examination characteristics in hepatic and bile duct disease 109. Gastrointestinal tumors (upper) 110. Laboratory findings and diagnostic methods in hepatic and bile duct disorders 111. Jaundice, approach to patient with jaundice 112. Gastrointestinal tumors (lower) 113. Pancreas (exocrine) pathology 114. Chronic liver disease / Cirrhosis 115. Viral Hepatitis 116. Approach to infectious diarrheae in adults-Clinical features and Diagnosis 117. Laxatives, purgatives, antidiareics, oral rehidratation salts 118. Gastrointestinal system injuries 119. Hepatobiliary and pancreatic tumors 120. Approach to patient with ascites 121. Surgical nutrition and metabolism 122. The principles of basic surgical techniques 123. Intraabdominal infections (peritonitis and abscess) 124. Cirrhosis 125. Liver tumors

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 42/125 3rd Year Courses Course 3.0: Introduction to Internal Medicine Practice Chair: Prof. Dr. Aydın Tunçkale, Internal Medicine Phone: +902124143000/22412-22938 Secretary: +902124143000/21629 E-mail: [email protected] Vice Chairs: Prof. Dr. Zeki Öngen, Cardiology Assoc. Prof. Dr. Derya Uğurlu Uludüz, Neurology Members: Prof. Dr. Benan Müsellim, Pulmonary Medicine Assoc. Prof. Dr. Burhan Engin, Dermatology

Semester: 5

Credit of Course: 2

ECTS Credit of Course: 2

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%) Dermatology 0 2 4 Infectious Diseases 1 0 4 Physical Medicine and Rehabilitation 1 2 7 Pulmonary Medicine 2 4 14 Internal Medicine 6 10 39 Cardiology 3 6 21 Neurology 1 4 11 Total 14 28 100

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 43/125 Lectures of the Course No Title 1. Interviewing and history taking skills 2. History taking and general apperance examination 3. General apperance and vital signs 4. History taking and general apperance examination 5. Physical examination of the head, face and neck. Examination of the lymp nodes 6. Respiratory system symptoms (cough, dyspnea, haemopthysis) 7. Physical examination of the respiratory system 8. Cardiac symptoms 9. Physical examination of the cardiovascular system 10. Gastroenterological symptoms-1 (jaundice, Haematemesis, melena, ascites) 11. Gastroenterological symptoms-2 (dyspepsia, constipation, diarrhea, dysphagia) 12. Dermatological examination 13. Neurologic System Examination 14. Physical examination of the locomotor system 15. Evaluating the patient with fever and rash 16. Physical examination of the locomotor system

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 44/125 Course 3.1: Nerve System and Sensory Organs Chair: Prof. Dr. Ertan Yurdakoş, Physiology Phone: +902124143000/21609 Secretary: +902124143000/21572 E-mail: [email protected] Vice Chairs: Prof. Dr. Sibel Ertan, Neurology Prof. Dr. Ayşe Derya Ertem, Anatomy Members: Prof. Dr. Aydın Barlas, Pharmacology Assoc. Prof. Dr. Emine Elif Güzel, Histology

Semester: 5

Credit of Course: 15

ECTS Credit of Course: 15

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%)

Anatomy 32 14 24 Biochemistry 1 0 1 Dermatology 2 0 2 Infectious Diesases 5 0 3 Pharmacology 18 0 11 Physiology 30 10 21 Opthalmology 2 0 2 Histology 18 2 11 Otorhinolaryngology 2 0 2 Neurology 13 0 8 Neurosurgery 3 0 2 Nuclear Medicine 1 0 1 Pathology 12 4 9 Pediatrics 1 0 1 Radiology 2 0 2 Total 142 30 100

Course aims and learning outcomes Course content This course provides information about the normal structure,development and functions,system related diseases,etiology,symptoms basic clinical and laboratory findings, diagnostic methods and also drugs used for the treatment of related diseases of the nerve system and sensory organs

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 45/125 Course aims The aim is to teach the basic information about the functions, structure, development and physiopathology of Nerve System and Sensory Organs, and basic clinical and laboratory diagnostic methods, drugs used for the treatment of related diseases Learning At the end of Nerve System and Sensory Organs course the students should be outcomes able to: 1. Describe the anatomical structures, 2. Describe the development and embryonic origins, 3. Describe the histological structures, 4. Describe the functional mechanisms, 5. Describe the sysmptoms, etiopathogenesis and histopathology of the diseases, 6. Describe the imaging techniques, 7. Describe the treatment methods, 8. Describe the drugs,their pharmacology,side effects and drug interactions for the treatment of related diseases of the nervous system and sensory organs Teaching Lectures,laboratory practices,clinical practices and demonstrations. methods and strategies

Lectures of the Course No Title 1. Neuroanatomy General View 2. Central Nervous System; Peripheral Nervous System: Definition 3. Synaptic and junctional transmission: Electrical and chemical events 4. Development of Head and Neck (1/3) 5. General characteristics of synapses and reflexes 6. Monosynaptic reflexes- The strech reflex 7. Development of Head and Neck (2/3) 8. Meninges 9. Prosencephalon 10. Development of Head and Neck (3/3) 11. General histology of nervous system 12. Polysynaptic reflexes: The withdrawal reflex 13. Subcortical gray matter 14. Subcortical white matter The protection of the Central Nervous System (CNS): Physiologic characteristics of 15. cerebro-spinal-fluid and the blood-brain-barrier 16. Histology of medulla spinalis, brain stem and peripheral nervous system 17. Initiation of impulses in sense organs and the antero lateral system 18. The consideration of Sensory information: cuteneous, deep and visceral sensation 19. Histology of cerebellum and cerebrum 20. Diencephalon Early development of neural tube- Development of medulla spinalis and peripheral 21. nervous system 22. Development of brain stem, cerebellum and cerebrum 23. The physiologic characteristics of the pain 24. Mesencephalon 25. Pons 26. Medulla oblongata 27. Cerebral Cortex 28. Congenital malformations of the nervous system 29. Thalamus and The Reticular Formation 30. EEG,Sleep and Evoked Potentials 31. Cerebellum 32. Corticospinal and Corticobulber Systems 33. Vessels of Central Nervous System I 34. Vessels of Central Nervous System II 35. Histology of the skin

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 46/125 No Title 36. Posture Regulating Systems 37. Brain Ventricles and CSF (Cerebrospinal Fluid) 38. Spinal cord Anatomy 39. Medullary Mechanisms and The Decebrate Rigiditiy 40. Posture and The Vestibular System 41. Midbrain 42. Spinal cord: Ascending Tracts 43. Spinal cord: Descending Tracts 44. The Basal Ganglia 45. Cranial nerves 46. Cranial nerves 47. The Cerebellum Interaction of The Cerebellum and The Basal Ganglia in The Control of The Motor 48. Functions 49. The Speech Formation and The Lateralization in The Brain 50. Association Areas of The Cerebral Cortex 51. Cranial nerves 52. Spinal Nerve Plexuses I 53. Spinal Nerve Plexuses II 54. The Hypothalamus 55. The Limbic System 56. Autonomic Nervous System 57. Autonomic Plexuses I 58. The Physiology of Learning and Memory 59. Histology of the skin 60. Biochemistry of Neurotransmission 61. Autonomic Plexuses II 62. The physiologic characteristics of hearing 63. The physiologic mechanisms of central audition 64. Autonomic Innervation of organs 65. Sense organs 66. Development of skin 67. Ear I 68. Ear II 69. Taste and Smell Sensations 70. Histology of Ear 71. Skin; Tongue; Nose 72. Eye I 73. Eye II 74. Development of Ear 75. Histology of Eye (1/2) 76. Histology of Eye (2/2) 77. Vision, Photoreceptor Mechanisms 78. Responses in the Visual Pathways 79. Development of Eye 80. Image forming mechanism 81. I Introduction to anomalies, edema CNS pathology 82. Red Eye 83. Transmission of pain, inflammation and their mediators 84. Neurological examination 1/2 85. Vascular disease of CNS travma 86. The symptoms in ocular disease 87. Introduction to central nervous system pharmacology 88. Encephalitis and brain absces 89. Anxiolytic, Sedative and Hypnotic drugs 90. Neurological examination 2/2 91. Antidepressant drugs

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 47/125 No Title 92. Antimanic drugs 93. Frontal and temporal lobes; Anatomical localization and clinical findings 94. Mental Retardation 95. Rabies: Clinical manifectations and prophylaxis 96. Parietal and occipital lobes; Anatomical localization and Clinical findings 97. CNS Tumors 98. CNS Tumors 99. Cerebellum ;Anatomical localization and clinical findings 100. Head and Neck Radiology 101. Menengitis and encephalitis 102. Degenerative and demyelinazing disesaes 103. CNS stimulants and psychotomimetic drugs 104. Clinical findings of cranial nerve diseases 105. Tetanus: Clinical presentations and prophylaxis 106. CNS Radiology 107. Basal ganglia; Anatomical localization and clinical findings 108. Spinal cord; Anatomical localization and clinical findings 109. Viral Encephalitis 110. Alcohols and alcohol intoxication 111. Peripheric nerve system 112. Drugs used in the treatment of Alzheimer‟s disease 113. Drugs used in the treatment of Parkinson‟s disease 114. Brain stem ; Anatomical localization and clinical findings 115. General anesthetics: inhalation anesthetics 116. Inflammatory skin diseases I 117. Inflammatory skin Diseases II 118. Central nervous system developmental abnormalities and clinical findings 119. General anesthetics: intravenous anesthetics 120. Clinical findings in peripheral nerve diseases 121. Principles of dermatologic diagnosis 122. Eye Pathology 123. Clinical findings in neuromuscular junction and muscle disease 124. Local anesthetics 125. Symptom and Practice in Dermatology 126. Opioid analgesics and antagonists (1/2) 127. Opioid analgesics and antagonists (2/2) 128. Tumoral Lesions of skin 129. Clinical diagnosis in chronic menengitis 130. Sleep and wakefulness 131. Introduction to Neurosurgery 132. Coma and delirium 133. Antiepileptic drugs (1/2) 134. Antiepileptic drugs (2/2) 135. Nuclear Medicine in Central Nervous System 136. Raised Intracranial Pressure 137. Vertigo and Tinnitus 138. Vertigo and Tinnitus 139. Clinical diagnosis in Acute menengitis Neurosurgical Approach to Neurological Symptoms: From Symptom to Diagnosis (Case 140. Discussion) 141. Neuroleptic drugs (1/2) 142. Neuroleptic drugs (2/2)

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 48/125 Course 3.2: Genitourinary System

Chair: Prof. Dr. Altay Gezer, Gynecology and Obstetrics Phone: +902124143000/21406 Secretary: +902124143000/21539 E-mail: agezer@superonlıne.com Vice Chairs: Prof. Dr. Mehmet Rıza Altıparmak, Internal Medicine Prof. Dr. Mehmet Seven, Medical Genetics Members: Prof. Dr. İsmail Seçkin, Histology Prof. Dr. Şennur İlvan, Pathology

Semester: 5

Credit of Course: 13

ECTS Credit of Course: 13

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%) Anatomy 7 14 9 Biochemistry 3 4 3

2 0 2 Infectious Diseases Pharmacology 6 0 4 Physiology 12 2 9 General Surgery 2 0 2 Histology 12 6 10 Internal Medicine 9 0 6 Gynecology and Obstetrics 23 0 15 Nuclear Medicine 1 0 1 Pathology 14 4 11 Pediatrics 4 0 3 Radiology 3 0 2 Medical Genetics 28 0 19 Urology 6 0 4 Total 132 30 100

Course aims and learning outcomes Course content The course provides the information about the normal structure, development and function of the genitourinary system. System related disaeses are reviewed to teach the basic knowledge on etiology, physiopathology and to gain basic skills on signs and symptoms,diagnostic methods, laboratory investigation and treatment.

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 49/125 Course aims The course aims to teach the information about the normal structure, development and function of the genitourinary system. System related disaeses are reviewed aiming to teach the basic knowledge on etiology, physiopathology and to gain basic skills on signs and symptoms,diagnostic methods, laboratory investigation and treatment Learning By the end of the course, students should be able to; outcomes 9. Describe the anatomical structures, 10. Describe the embriological origins and the development 11. Describe the histological pattern 12. Describe the fuctions and mechanisms of the genitourinary system. 13. Describe the etiology, physiopathology of the diases of the genitourinary system and the pathological changes due to related diseases. 14. List the basic clinical signs and symtoms of the diseases of the genitourinary system, the diagnostic tests (radiological and biochemical etc.) and the results of this tests 15. List the basic treatment of diseases of the genitourinary sysytem, drugs used in the treatmet (concerning the action, mechanism of action, pharmacokinetics, adverse effects, drug and drug relations). Teaching Lectures, clinical and laboratory practical workshop, question & answer, methods and demonstrations strategies

Lectures of the Course No Title 1. Urinary and Genital Systems: Introduction 2. The Neurohypophysis and ADH 3. Gonad Hormones: Male 4. Histology of Urinary System 5. Endocrine Physiology: The male gonad hormones 6. Histology of Urinary System 7. Kidneys, Ureters, 8. Gonad Hormones: Female 9. Endocrine Physiology: The female gonad hormones 10. Male reproductive organs I 11. Histology of Urinary System 12. Biochemical evaluation in renal disorders 13. Endocrine Physiology: The physiologic characteristics of the menstruel cycle 14. Male reproductive organs II 15. Histology of Urinary System 16. Female reproductive organs I 17. Female reproductive organs II 18. Histology of Male Genital System 19. Endocrine Physiology: Pregnancy, labor and lactation 20. Lactation and fertility control 21. Perineum 22. Histology of Male Genital System 23. Histology of Male Genital System 24. Functions of the Kidneys and Its importance, Physiology of Nephron Urine Formation by the Kidneys: Glomerular Filtration, Tubular Reabsorption and 25. Tubular Secretion 26. Regulation of Glomerular Filtration Rate and Renal Blood Flow 27. Histology of Female Genital System 28. Histology of Female Genital System 29. Development of Urogenital System (1/3) 30. History taking and physical examination in kidney disease 31. Renal mechanisms of Urine Dilution and Concentration 32. Control of Potassium and Sodium Concentration in Extracellular Fluid 33. Micturition Reflex, Renal Control of Acid-Base Balance

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 50/125 No Title 34. Development of Urogenital System (2/3) 35. Renal anomalies, cystic diseases of kidney 36. Proteinüria - Hematuria 37. Development of Urogenital System (3/3) 38. Gynecologic and obstetric history taking and examination 39. Urinalysis and its clinical importance 40. Gene structure and function 41. Mendelian inheritance 42. Urologic examination and taking history 43. Radiology of the Urological System 44. Non-mendelian inheritance 45. Glomeruler Diseases Pathogenesis and Histologic Features 46. Newborn 47. Oliguria and polyuria 48. Menstrual cycle and its neuroendocrine control 49. Urolithiasis 50. Gonodal Hormones and inhibitors (1/4) 51. Urological malignancy 52. Urinary tract infections 53. Primary GN 54. Multifactorial - Polygenetic Inheretance 55. Abnormal uterine bleeding 56. Secondary GN 57. Gonodal Hormones and inhibitors (2/4) 58. Evaluation of renal functions 59. Chromosome disorders and analysis methods 60. Gonodal Hormones and inhibitors (3/4) 61. Urinary System Development 62. Normal and abnormal variations in genetic structure 63. Pelvic pain 64. Tubulointerstitial diseases of kidney 65. Sexually transmitted diseases 66. Fluid and electrolyte balance 67. Gonodal Hormones and inhibitors (4/4) 68. Fluid and electrolyte imbalance, dehydration 69. Physiology and disorders of voiding 70. Urinary system infections and sexually transmitted diseases 71. Diagnostic methods in molecular genetics 72. New diagnostic methods in genetics 73. Vaginal flour and abnormal vaginal discharge 74. Hydronephrosis, renal stones 75. Diagnostic tests and methods in obstetrics 76. Uteruse Pathology 77. Cytogenetic approach in pretanal and preimplantation genetics 78. Breast examination and Symptomatology 79. Renal tumors, urinary bladder carcinoma 80. Molecular approach in pretanal and preimplantation genetics 81. Hyper and hypopotassemia 82. Diagnostic tests and methods in gynecology 83. Erectile dysfunction 84. Acid-base balance and its disturbances 85. Testis pathology :Infertility, congenital anomailes, inflammation and tumors 86. Human reproduction 87. Nuclear Medicine in Genitourinary System 88. Cervical Pathology 89. Developmental genetics 90. Assisted reproduction in humans

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 51/125 No Title 91. Breast cancer 92. Screening of invasive and preinvasive lesions 93. Radiology of the Genital System 94. Dismorphology and multiple congenital abnormalities 95. Neural development disorders 96. Benign and melignant breast diseases 97. Vaginal and Vulvar Pathology 98. Fetal Radiology 99. Hereditary mental retardations and Fragile-X Syndrome 100. Gynecological cancers 101. Reproductive stages of women‟s life 102. Ovarian Pathology 103. Hyperandrogenism 104. Fetal and Placental Pathology 105. Breast Pathology 106. Chrosomal breakage syndromes 107. Obesity in obstetrics and gynecology 108. Diagnosis of pregnancy and prenatal care; screening tests in obstetrics 109. Microdeletion syndromes 110. Genetics of metabolic disorders 111. Cancer genetics 112. Molecular features of hematopoietic malignancies and genetic diagnosis 113. Development of fetus and placenta 114. Maternal changes and adaptation to pregnancy 115. Hereditary disorders of the cancer 116. Hereditary disorders of the blood 117. Premature 118. Bleeding in pregnancy 119. Pharmacogenetics, pharmacogenomics and personalized medicine in clinical practice 120. Effects of teratogens on human health 121. Normal labor 122. Effect of genetically modified organisms on human organism 123. Therapy of genetic disorders and gene therapy 124. Abnormal labor 125. Bioinformatics in medical genetics 126. Breast examination and diseases 127. Oxytocic drugs 128. Principles and problems in genetic counseling 129. Principles of drug use in pregnancy 130. Ethical and legal problems in medical genetics 131. Shock in Ob&Gyn 132. Family planning and contraception

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 52/125 Course 3.3: Topographic Anatomy - Biostatistics - Deontology

Chair: Prof. Dr. M. Yakup Tuna, Anatomy Phone: +902124143000/21563 Secretary: +902124143000/21563 E-mail: [email protected] Vice Chairs: Prof. Dr. Gürsel Çetin Forensic Medicine Prof. Dr. Hatun Hanzade Doğan, Deontology and History of Medicine Members: Prof. Dr. Mustafa Şükrü Şenocak, Biostatistics Assoc. Prof. Dr. Nurver Turfaner, Primary Care

Semester: 6

Credit of Course: 8

ECTS Credit of Course: 8

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%) Forensic Medicine 15 0 17 Primary Care 7 0 8 Anatomy 34 14 45 Biostatistics 12 0 13 Deontology and History of Medicine 11 0 12 Clinical Practices 0 12 5 Total 79 26 100

Course aims and learning outcomes Course content Topographic anatomy, forensic medicine, clinical biostatistics, medical ethics, primary care. Course aims Topographic Anatomy - Biostatistics - Deontology course provides knowledge about topographic structures, forensic Medicine,ethics, clinical biostatistics, and primary care. Learning By the end of this course the students should be able to: outcomes 16. Describe the topographic anatomy of human body, 17. Describe basic concepts of forensic medicine, 18. Have information about medical ethics, 19. Hold an opinion about biostatistics methods. 20. Describe the essentials of primary care. Teaching Lectures, clinical and laboratory practices, homework, demonstration. methods and strategies

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 53/125 Lectures of the Course No Title Introduction to the Aims and Significance of Medical and Clinical Ethics from a Global 1. Perspective 2. Upper Extremity 3. Shoulder 4. Introduction to Clinical Biostatistics 5. Legal responsibilities of physicians 6. Arm and forearm 7. History and Essentials of Primary Care, Global Applications and Applications in Turkey 8. Variables and Basic Design of Clinical Trials 9. Lower extremity 10. Hip and thigh 11. Clinical Problem Solving in Primary Care 12. Hands 13. Introduction to Theoretical and Applied Ethics 14. Back: General anatomy 15. Basics of death 16. Observation of Beneficence and Nonmaleficence During Clinical Practice 17. Foot 18. Periodic Health Examinations 19. Probability Evaluation, Bivariate and Multivariate Analysis 20. Knee and leg 21. Wounds 22. Pediatric death 23. Back: Clinical anatomy 24. Relative Risk Measures – OR, RR (1/2) 25. Upper Extremity: Clinical Anatomy 26. Lower Extremity: Clinical Anatomy 27. Justice and Allocation of Health in Clinical Practice 28. Approach to Hyperlipidemia in Primary Care 29. Approach to Hypertension in Primary Care 30. Relative Risk Measures – OR, RR (2/2) 31. Head: Surface anatomy 32. Head: Regions I 33. Violation of human rights 34. Head: Regions II 35. Diagnostic Tests (1/2) 36. Patient Autonomy and Implementation of Informed Consent in Medical Practice 37. Neck: Surface anatomy 38. Turkish Penal Code and Wounds I 39. Face 40. Head: Clinical Anatomy 41. Diagnostic Tests (1/2) 42. Neck: I Regions 43. Observation of Moral Values in Clinical Decision Making 44. Methods of Ethical Decision Making and Case Discussions 45. Neck: III Fasciae Thyroid and parathyroid glands 46. Neck: Clinical Anatomy 47. Neck: II Triangles 48. Alcohol and Drug Dependency 49. Ethical Dilemmas in Medical Practice and Clinical Ethics Committees 50. Survival Analysis (1/2) 51. Forensic Psychiatry and Behavorial Sciences 52. Approach to Geriatric Patient in Primary Care 53. Thorax: Mediastinum 54. Thorax: Surface anatomy 55. Thorax

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 54/125 No Title 56. Survival Analysis (2/2) 57. Evaluation of Association Among Clinical Decision Makers 58. Thorax: walls and Breasts 59. Clinical Trials and Research Ethics Committees 60. Abdomen:Surface Anatomy 61. Approach to Pain in Primary Care 62. Child Abuse and Parental Violence 63. Thorax: Clinical Anatomy 64. Natural Death 65. Patient and Physician Rights 66. Abdomen: Walls 67. Abdomen: Inguinal region 68. Abdomen 69. Abdomen: Clinical Anatomy 70. Asphyxia 71. Sampling 72. Forensic Identification 73. Craniocerebral Trauma 74. Pelvic regions 75. Significance of Virtue Ethics for Physicians 76. Pelvis and Perineum: Clinical Anatomy 77. Methodology and Biostatistics Concepts in Clinical Research Protocol 78. Forensic Toxicology 79. Turkish Penal Code and Wounds II

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 55/125 Course 3.4: Endocrine System and Metabolism Chair: Prof. Dr. Volkan Demirhan Yumuk, Internal Medicine Phone: +902124143000/21594 Secretary: +902124143000/21629 E-mail: [email protected] Vice Chairs: Prof. Dr. Dildar Konukoğlu, Biochemistry Prof. Dr. Saadet Olcay Evliyaoğlu, Pediatrics Members: Prof. Dr. Ayşe Sibel Erdamar Çetin, Pathology Prof. Dr. Nuran Darıyerli Toktamış, Physiology

Semester: 6

Credit of Course: 12

ECTS Credit of Course: 12

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%) Anatomy 2 2 3 Biochemistry 19 0 18 Pharmacology 13 0 12 Physiology 12 6 14 General Surgery 3 0 3 Histology 4 2 5 Internal Medicine 22 0 22 Nuclear Medicine 1 0 1 Pathology 6 4 8 Pediatrics 8 0 8 Radiology 1 0 1 Clinical Practices 0 15 5 Total 91 29 100

Course aims and learning outcomes Course content Endocrine System and Metabolism course gives information and skills about the normal structure, development and functions, system-related diseases, etiology, symptoms, basic clinical and laboratory findings, diagnostic methods for Endocrine System and Metabolism and drugs used for related diseases. Course aims Teaching function, structure, development and physiopathology of Endocrine System and Metabolism, and basic clinical and laboratory diagnostic methods, drugs used for related diseases.

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 56/125 Learning By the end of Endocrine System and Metabolism course the students should be outcomes able to: 21. Describe anatomical structures, 22. Describe development and embryonic origins, 23. Describe histological structure, 24. Describe functions and mechanisms of the endocrine system, 25. List the etiology, physiopathology, symptoms and laboratory findings of the diseases of the endocrine system and the pathological changes due to related disases 26. Describe the imaging techniques 27. List the treatment options of endocrin system diseases, 28. Describe the effects, mechanisms of action, pharmacokinetics, side effects and interactions of the drugs used in the treatment of diseases of the endocrine system Teaching Lectures, clinical and laboratory practices, homework, demonstration. methods and strategies

Lectures of the Course No Title 1. Endocrine system (1/2) 2. Endocrine system (2/2) 3. General Features of Hormones (1/2) 4. General Features of Hormones (2/2) 5. Endocrine System: Pituitary 6. Mechanisms of Hormone Action (1/2) 7. Mechanisms of Hormone Action (2/2) 8. Pituitary and Hypothalamic Hormones 9. Endocrine System: Adrenal and pineal gland 10. Adrenal cortex hormones: Glucocorticoids 11. Pituitary Hormones and The Hypotahalamic Control(1/2) 12. Pituitary Hormones and The Hypotahalamic Control(2/2) 13. The Adrenal Gland: Glucocorticoids 14. The Adrenal Medulla and The Renin Angiotensin System 15. Adrenal cortex hormones: Mineralocorticoids 16. Endocrine System: Thyroid and parathyroid glands 17. Hormones of the Adrenal Medulla 18. Hormonal Regulation of The Bone Formation 19. Adrenal gland: Medullary hormones 20. The Thyroid Gland 21. Hormonal regulatıon mechanisms of hypo and hyperglycemia 22. Thyroid Hormones 23. Parathyroid Hormones 24. Pancreas hormones 25. Fuel metabolism in diabetes 26. Biochemistry of acute and chronic diabetic complications 27. The Endocrine Functions of The Pancreas 28. Endocrine System: DNS system, islets of Langerhans 29. Neurotransmitters and hormones that influence food intake 30. Short and long term regulation of food intake 31. Metabolism and factors that affect basal metabolic rate 32. Metabolic homeostasis: Metabolic relationship among adipose tissue, muscle and liver 33. Hormones of the Adipocyte 34. Biochemical Evaluation of Inborn Errors of Metabolism 35. Biochemical Evaluation of Vitamin Metabolism Disorders 36. Biochemical Evaluation of Trace Element Metabolism Disorders 37. Lipoprotein Metabolism 38. Surgery of the Endocrine system: Adrenal

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 57/125 No Title 39. Introduction to endocrine pharmacology 40. Hypothalamus and pituitary Hormones and inhibitors (1/2) 41. Endocrine System Development 42. Symptomatology of endocrinology 43. Hypothalamus and pituitary Hormones and inhibitors (2/2) 44. Growth - Puberty 45. Pituitary Tumors 46. Adolescent 47. Neonatal endocrinology 48. Puberty 49. Anterior pituitary disorders 50. Adrenal Diseases 51. Short Stature 52. Hypothalamus and posterior pituitary disorders 53. Hypocorticism 54. Thyroid Hormones and Antithyroid drugs (1/2) 55. Adrenal cortex Hormones and inhibitors (1/2) 56. Adrenal cortex Hormones and inhibitors (2/2) 57. Thyroid Hormones and Antithyroid drugs (2/2) 58. Surgery of the endocrine system: Thyroid 59. Hypercorticism 60. Endocrine hypertension 61. Hyperplastic Lesions of thyroid gland 62. Basedow Disease, thyroiditis, thyroid tumors 63. Nontoxic diffuse and nodular goiter-thyroid cancer 64. Thyrotoxicosis 65. Hypothyroidism and thyroidites 66. Drugs affecting bone and mineral homeostasis (1/2) 67. Surgery of the endocrine system: Parathyroid 68. Nucleer Medicine in Endocrine System 69. Calcium homeostasis and metabolic bone diseases 70. Drugs affecting bone and mineral homeostasis (2/2) 71. Parathyroid Diseases 72. Male reproductive system disorders 73. Principals of nutrition 74. Female reproductive system disorders 75. Insulin and Oral Antidiabetic Drugs (1/3) 76. Tip -II Diabetes Mellitus 77. Introduction to inherited metabolic disorders 78. Diabetic neuropathy 79. Obesity 80. Insulin and Oral Antidiabetic Drugs (2/3) 81. Insulin and Oral Antidiabetic Drugs (3/3) 82. Type 1 diabetes mellitus 83. Endocrine Pancrease Pathology 84. Acute complications of diabetes 85. Diabetic nephropathy 86. GI hormones and endocrine tumors 87. Lipoprotein metabolism disorders 88. Macrovascular complications of diabetes 89. Endocrine System Radiology 90. Drugs used in the treatment of obesity 91. Hypoglycemias

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 58/125 Course 3.5: Clinical Microbiology and Infectious Diseases

Chair: Prof. Dr. Neşe Saltoğlu, Infectious Diseases Phone: +902124143000/22848 Secretary: +902124143000/21688 E-mail: [email protected] Vice Chairs: Prof. Nevriye Gönüllü, Microbiology Prof. Dr. Sibel Özyazgan, Pharmacology Members: Prof. Dr. Ayşe Eroğlu, Pediatrics Assoc. Prof. Dr. Kağan Zengin, General Surgery

Semester: 6

Credit of Course: 10

ECTS Credit of Course: 10

Departments Included in the Course Lecture (hour) Practice (hour) Proportion (%) Infectious Diseases 19 0 19 Pharmacology 18 0 17 General Surgery 1 0 1 Microbiology and Clinical Microbiology 52 12 54 Nuclear Medicine 1 0 1 Pediatrics 3 0 3 Clinical Practices 0 18 5 Total 94 30 100

Course aims and learning outcomes Course content Includes the basic informations about microorganisms, parasites, bacteria and fungi, clinical and laboratory properties of common infectious diseases and properties of drugs used for infectious diseases. Course aims It is aimed to teach basic informations about microorganisms and caused diseases, tools for diagnosis, treatment modalities for future use. Learning At the end of Clinical Microbiology and Infectious Diseases Course, the studens outcomes should be able to:

Describe pathogenic microorganisms and their characteristics Describe symptoms of infectious diseases, clinical, laboratory and, histopathological basic findings Describe the procedures for diagnosis of infectious diseases Describe the differential diagnosis and management of infectious diseases Describe the effects, mechanisms of action and pharmacokinetics of chemotherapeutics used for infectious disease. Teaching Lectures, clinical and laboratory practices, demonstrations. methods and strategies

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 59/125 Lectures of the Course No Title 1. Cell structure of bacteria and medically important bacterial pathogens 2. Genetic exchanges in bacteria and its outcomes 3. Immunology of bacterial infections 1 4. Immunology of bacterial infections 2 5. Vaccination Principles 6. Vaccination in adults and immunosuppressive patients 7. Septic shock 8. Principles of Diagnostic Medical Microbiology 1 9. Principles of Diagnostic Medical Microbiology 2 10. Basic principles of chemotherapy 11. Spectra of antibiotics 12. Antibiotic resistance in bacteria 13. Anamnesis and Physical Examination in Infectious Diseases 14. Laboratory findings in Infectious Diseases 15. Clinical uses of antimicrobials 16. Beta lactam Antibiotics (1/3) 17. The streptococci 1 18. The streptococci 2 19. The staphylococci 20. Bacillus species 21. Fever 22. Fever pathogenesis and clinical fever features 23. Approach to the patients with fever and rash 24. Rash 25. Emergency in Infectious diseases 26. Beta lactam Antibiotics (2/3) 27. Beta lactam Antibiotics (3/3) 28. Antistaphylococcal antibiotics and drugs used against urinary system infections 29. Other cell wall synthesis inhibitors 30. Protein synthesis inhibitors: Amphenicols 31. Corynebacterium and Listeria species 32. Nocardia and actinomycetes species and other facultative anaerob gram positive rods 33. Antimicrobial chemoprophylaxis in clinical practice 34. Differential Diagnosis in Infectious Diseases 35. Protein synthesis inhibitors: Macrolides- Lincosamides 36. Protein synthesis inhibitors: Tetracyclines 37. Extrapulmonary tuberculosis 38. Mycobacterium tuberculosis 1 39. Mycobacterium tuberculosis 2 40. Protein synthesis inhibitors: Aminoglycosides 41. Quinolones 42. Mycobacterium leprae and other mycobacteria 43. The Neisseriae 44. Enteric Gram negative rods 1 45. Enteric Gram negative rods 2 46. Salmonellosis 47. Vibrios and other associated bacteria 48. Campylobacter and Helicobacter 49. The Brucellae 50. Brucellosis 51. Nonfermentative Gram negative bacteria 52. The Haemophilus species 53. Bordatella and Legionella species 54. Sulphonamides 55. Francisella,Pasteurella, and Eikenella

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 60/125 No Title 56. Antianaerob drugs 57. Spirochets and other spiral microorganisms 58. Anaerobic gram positive rods 59. Anaerobic gram negative rods and cocci 60. Antiprotozoals (1/2) 61. Nosocomial Infections 62. Importance of Dysinfection and sterilization in Hospital infection control 63. Transfusion related infections 64. Chlamydia and Chlamydophila species 65. Rickettsia, Ehrlichia, Coxiella, Bartonella 66. Infections in special hosts 67. HIV, AIDS: Clinical features, laboratory diagnosis 68. Introduction to parasitology 69. Intestinal protozoa 1 70. Intestinal protozoa 2 71. Epidemiology of infections 72. Interpretation of epidemiological data 1 73. Interpretation of epidemiological data 2 74. Blood and Tissue protozoa 1 75. Antiprotozoals (2/2) 76. Antihelmintic drugs 77. Malaria 78. Blood and Tissue protozoa 2 79. Trichomanos vaginalis and other amebas 80. Soft tissue infections 81. Scintigraphic imaging of Infection and Inflammation 82. Introduction to Helminthology and general characteristics of helminths 83. Nematodes 1 84. Nematodes 2 85. Trematodes 1 86. Trematodes 2 87. Drugs against ectoparasides 88. Cestodes 1 89. Cestodes 2 90. The classification and general characteristics of arthropods 91. Arthropoda Class Insecta mosquitoes, sandflies, bedbugs, fleas and louses 92. Arachnida class of arthropods ticks and mites 93. Clinical use of antimicrobials

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 61/125 4th Year Clerkships  Internal Medicine (10.5 weeks)  Pediatrics (10.5 weeks)  Gynecology and Obstetrics (7 weeks)  General Surgery (7 weeks)  Anesthesiology and Reanimation (2 weeks)  Radiodiagnostics (1.5 weeks)  Urology (3.5 weeks) Total: 42 weeks.

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 62/125 Internal Medicine Head of Department: Prof. Dr. Teoman Soysal Phone: +902124143000/22008 Secretary: +902124143000/21629 E-mail: [email protected]

Semester: 7-8

Credit of Course: 15

ECTS Credit of Course: 15

Clerkship aims and learning outcomes Clerkship content Internal Medicine Clerkship provides an overview of important aspects of internal Medicine. Course aims At the end of the clerkship period students should acquire proficiency in the diagnosis and the treatment of common primary health care problems that are related to internal medicine Learning Theoretical Knowledge outcomes Students who have completed their training of Internal Medicine should be able to discuss the differential diagnosis of basic symptoms related to internal medicine: Fever, abdominal pain, chest pain, shortness of breath, cough, and hemoptysis, weight loss, headache, For the following topics; they should be able to describe the condition, make the correct diagnosis, plan the treatment, organize follow up, able to count situations that a referral should be made. Osteoporosis, and metabolic bone disease, hypertension, type 2 diabetes mellitus, hyperlipidemias, and obesity, complications and treatment of morphological and functional changes in aging, drug use characteristics in elderly, peptic ulcer disease, gastritis, arthritis differential diagnosis of common rheumatic diseases, local and generalized pain, laboratory tests in rheumatology, emergencies in nephrology, anemia, the basic principles of medical oncology, cancer epidemiology and etiology, screening and early diagnosis of cancer For the following topics; they should be able to describe the condition, make the preliminary diagnosis, (if necessary) plan the emergency treatment, able to count situations that a referral should be made, help the long term the follow up (under supervision of secondary health care provider) Resistant hypertension, poisoning, pulmonary thromboembolism, systemic sarcoidosis, type 1 diabetes mellitus, hypothyroidism, thyroiditis, hyperthyroidism, functional diseases of the digestive system, diseases of the esophagus, gastrointestinal system bleeding, gastrointestinal polyps and diverticular disease, complications and treatment, chronic diarrhea, gall bladder stones, extrahepatic biliary tract diseases, metabolic liver diseases, chronic hepatitis B, chronic hepatitis C, liver cirrhosis, alcoholic liver disease and nonalcoholic fatty liver disease, rheumatoid arthritis, crystal arthritis, seronegative spondyloarthropathy, Behcet's syndrome, familial Mediterranean fever (FMF), chronic renal failure , Interstitial kidney disease, polycystic kidney, and congenital-hereditary kidney disease, diabetic nephropathy, cancer screening and early diagnosis, oncologic emergencies For the following topics; they should be able to describe the condition, make the preliminary diagnosis, (if necessary) plan the emergency treatment, able to organize timely referral to appropriate unit. Sarcoidosis, systemic, pituitary disease, adrenal disease, nodular goiter and thyroid cancer, parathyroid disease, reproductive system disorders, inflammatory bowel disease, acute and chronic pancreatitis, mesenteric ischemia, systemic diseases, liver, autoimmune liver disease, acute liver failure, systemic vasculitis,

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 63/125 systemic sclerosis, systemic lupus erythematosus, dermatomyositis polimiyozitve, autoinflammatory diseases, glomerular diseases, acute renal failure, systemic diseases and kidney, renal replacement therapy, pancytopenia, thrombocytopenia and qualitative platelet disorders, bleeding diathesis, hemophilia and von Willebrand disease, disseminated intravascular coagulation, principles of treatment of thrombophilia and anticoagulation, paraproteinemias and multiple myeloma, MDS and acute leukemias, chronic leukemias, Hodgkin's Disease, Non- Hodgkin's Lymphoma, lung cancer, breast cancer, gastrointestinal cancers, liver, pancreas, GEP-NET and GIST, gynecological cancers, urological cancers, paraneoplastic syndromes, palliative and supportive care of cancer, metastatic cancer of unknown primary, molecular oncology, cytotoxic chemotherapy and targeted therapies

Skills - Be able to take the correct and detailed (general and problem oriented) history, be able to keep accurate records. Be able to do a complete and accurate physical examination. - Be able to help during the implementation of the basic procedures that are related to internal medicine (thoracentesis, paracentesis, intravenously, İ.M, S.C. drug application). Be able to make blood glucose monitoring, prepare peripheral blood smear, able to provide oxygen for the patient with oxygen set.

Attitude -Health team and the staff helpful and able to communicate effectively and compatible. -Questioning and searching for new sources of information Teaching methods Bedside teaching, ward-rounds, seminars and strategies

Lectures No 1. History-taking and interwiew techniques 2. Exemination of the general condition of the patient, evaluation of patient appereance 3. History-taking and physical examination of the respiratory system, pulmonary function testing 4. History-taking and physical examination in nephrology, urinanalysis 5. History-taking and physical examination in gastroenterology 6. History-taking and physical examination symptoms and findings of the endocrine syystem 7. History-taking and physical examination rheumatology 8. History-taking and physical examination and the findings of the hematopoietic system 9. Interpretation of the diagnostic tests (specifity, sensitivity, positive and negative predictive tests) 10. Differential diagnosis in a patient presenting with abdominal pain 11. Differential diagnosis in a patient presenting with edema 12. Differential diagnosis in a patient presenting with dyspnea 13. Differential diagnosis in a patient presenting with chest pain 14. Differential diagnosis in a patient presenting with hemoptysis 15. Differential diagnosis in a patient presenting with weight loss 16. Resistant hypertension 17. Pulmonary emboli 18. Systemic sarcoidosis 19. Atypical pneumonias 20. Community acquired pneumonias 21. Preoperative assessment of surgical patients 22. Anterior pituitary disorders 23. Posterior pituitary disorders 24. Adrenal disorders-1

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 64/125 No 25. Adrenal disorders-2 26. Hypothyroidism & thyroidites 27. Hyperthyroidism 28. Nodular goiter & thyroid cancer 29. Parathyroid diseases 30. Osteoporosis & metabolic bone disease 31. Reproductive system disorders 32. Management of type 1 diabetes mellitus 33. Management of type 2 diabetes mellitus 34. Acute complications of diabetes mellitus 35. Chronic complications of diabetes mellitus 36. Diabetes & pregnancy 37. Hyperlipidemias and their management 38. Obesity: Management & its complications 39. History taking & PE in the elderly 40. Morphological & functional changes of aging 41. Multifaceted geriatric evaluation 42. Laboratory evaluation in the elderly 43. Nutrition principles in the elderly 44. Geriatric syndromes-1 45. Geriatric syndromes-2 46. Infectious diseases in the elderly 47. Drug treatment in the elderly 48. Functional disorders of the digestive system 49. Clinical findings & diagnosis of esophageal disorders 50. Treatment of esophageal disorders 51. Peptic ulcer disease: Etiopathogenesis & clinical presentation 52. Gastrites 53. Gastrointestinal system bleeding 54. GI polyps and diverticulae 55. Inflammatory bowel disease: Complications & management 56. Chronic diarrhea 57. Gall stones 58. Acute & chronic pancreatites 59. Mesenteric ischemia 60. Extrahepatic bile duct disorders 61. Liver in systemic diseases 62. Metabolic liver disease 63. Chronic Hepatitis B 64. Chronic Hepatitis C 65. Autoimmune liver disease 66. Acute hepatic failure 67. Liver cirrhosis 68. Alcoholic liver disease & Non-alcoholic steatohepatitis 69. Differential diagnosis of arthritis 70. Widespread pain & local rheumatological diseases 71. Laboratory in Rheumatology 72. Rheumatoid arthritis 73. Systemic vasculitis-1 74. Systemic vasculitis-2 75. Seronegative spondylarthrities 76. Systemic sclerosis 77. Systemic lupus erythematosus 78. Behçet‟s disease 79. Polimyositis & Dermatomyositis 80. Autoinflammatory diseases 81. Familial Mediterrannean Fever

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 65/125 No 82. Glomerular diseases-1 83. Glomerular diseases-2 84. Glomerular diseases-3 85. Acute renal injury-1 86. Acute renal injury-2 87. Chronic renal failure -1 88. Chronic renal failure -2 89. Chronic renal failure -3 90. Interstitial diseases of the kidney 91. Policystic kidney & congenital kidney diseases 92. Systemic diseases & kidney 93. Diabetic nephropathy 94. Renal replacement therapy-1 95. Renal replacement therapy-2 96. Emergencies in nephrology-1 97. Emergencies in nephrology-2 98. Emergencies in nephrology-3 99. Differential diagnoses of anemias 100. Pancytopenia 101. Thrombocytopenias & qualitative thrombocyte disorders 102. Bleeding disorders 103. Hemophilias & von Willebrand Disease 104. Disseminated intravascular coagulation 105. Trombophilia & principles of anticoagulation 106. Transfusion medicine 107. Paraproteinemias & multiple myeloma 108. MDS & acute leukemias-1 109. Acute leukemias-2 110. Chronic leukemias 111. Hodgkin‟s disease 112. Non-Hodgkin lymphomas 113. Basic principles of medical oncology 114. Etiology &epidemiology of cancer 115. Early diagnosis & screening in cancer 116. Lung Cancer 117. Breast cancer 118. Gastrointestinal cancers-1 119. Gastrointestinal cancers-2 120. Liver, pancreas GEP-NET & GIST 121. Gynecologic cancers 122. Urologic cancers-1 123. Urologic cancers-2 124. Paraneoplastic syndromes 125. Palliative and supportive care of cancer 126. Cancer of unknown origin 127. Molecular oncology 128. Cytotoxic chemotherapy & targeted therapies 129. Emergencies in oncology

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 66/125 Çocuk Sağlığı ve Hastalıkları / Pediatrics Head of Department: Prof. Dr. Salim Çalışkan Phone: +902124143000/22036 Secretary: +902124143000/21831 E-mail: [email protected]

Semester: 7-8

Credit of Course: 15

ECTS Credit of Course: 15

Clerkship aims and learning outcomes Clerkship content 1. Child development 2. Child alimentation 3. The problems of newborn period 4. Gastrointestinal system diseases in children 5. Kidney and urinary tract diseases in children 6. Cardiovascular diseases in children 7. Genetic diseases 8. Metabolic diseases 9. Adolescent Problems 10. Endocrine diseases 11. Neurological diseases 12. Treatments and immunization 13. Hematologic diseases and malignant diseases in children 14. The problems requiring emergency intervention for child. Course aims The goal of this clerkship is to provide students knowledge related child development, nutrition, preventive medicine, diagnosis and treatment of common pediatric diseases. Learning To teach things on the aim of the course part to students. outcomes Teaching methods Lectures, case presentations, clinical practices. and strategies

Lectures No 1. Primary Care of the newborn 2. Neonatal Hiperbilirubinemia 3. High Rish Neonate 4. Metabolic Problem in Newborn 5. Upper Respiratory Infek. - I 6. Upper Respiratory Infek. - II 7. Encephalitis 8. Meningitis 9. Parotitis 10. Atophy Eczema 11. Pertussis 12. Respiratory Problems of Neonatal 13. Intrauterin Inf. 14. Neonatal Sepsis 15. Hypoxemic Newborn 16. Growth and Development - I

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 67/125 No 17. Growth and Development - II 18. Bronciholitis – Asthma - I 19. Bronciholitis – Asthma - II 20. Pneumonia - I 21. Pneumonia - II 22. Pubertal Disorders 23. Vaccination - I 24. Vaccination - II 25. Complementary Nutrition 26. Nutrition - I 27. Nutrition - II 28. Lysosomal Dysplasia 29. Skeletal Diseases 30. Down Syndrome 31. Mycocarditis 32. Acute Hepatitis 33. Cholestasis 34. Tubercülosis - I 35. Tubercülosis - II 36. Peptic Disease 37. Exanthem - I 38. Exanthem - II 39. Febril Seizures and Non Epileptic P.D. 40. Immun Deficiency – I 41. Immun Deficiency - II 42. Breastfeeding 43. Parositosis 44. Rachitis 45. Growth Hormone Deficiency 46. Pubertal Disorders 47. Coma 48. Adrenogenital Sydrome 49. Hypotirodyzm 50. Metabolic Diseases - I 51. Metabolic Diseases - II 52. Metabolic Diseases - III 53. Malabsorpsion Coeliac D.– I 54. Articanria - Angioedema 55. Diabetes Mellitus 56. Cystic Fibrosis 57. Obesity 58. Cardiologic Diseases - I 59. Cardiologic Diseases - II 60. Muscle Disease 61. ASD - PDA 62. VSD 63. Congenital Cyanotic Hearth Disease 64. Valve Disorders 65. Endocarditis - Pericarditis 66. Epilepsy 67. Atophy Eczema 68. Abnormal Findings in neurology 69. Polyradicüloneuritis 70. Neuro – behavioral Problems in C. 71. Fluid Therapy - I 72 Fluid Therapy - II 73. Intoxications

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 68/125 No 74. Iron Deficiency Anemia 75. Solid Tumors 76. Emercery in Pediatric Hematology - Oncology 77. Transfusion 78. Thrombosis - DIC 79. Hemophilia and Secondary bleeding disorders 80. Childhood Leukemias and Lymphomas 81. Childhood Anemias Etiology – Clinical signs and diagnosis 82. Thrombocyte disorders and ITP 83. Haemopoesis and morphology 84. Hemolitic Anemias 85. Providing Care to Adolescent - I 86. Providing Care to Adolescent - II 87. Somatic Symptoms in Adolescence 88. Common Problems and Heath Risk Behaviors in Adolescent 89. Adolescent Preventile Services 90. Child Rights 91. Vasculitis 92. Systemic Lupus, Scleroderma 93. FMF 94. Juvenile İdiopatic Artrit 95. Acute Remal Failure 96. Acute Poststreptococcal Glomerulonephritis 97. Hypertension 98. Chronic Renal Failure 99. Hemolytic Uremic Syndrome 100. Congenital Urinary tract Anomalies 101. Voiding dysfunction and Enüresis 102. Tubular Disorders 103. Urinary tract Infection 104. Rabdomiyolis 105. Hypoglisemi 106. Malabsorpsion Coeliac D.– I,II 107. Otoenflamatuary diseases and Familial meditarian fever - I 108. Otoenflamatuary diseases and Familial meditarian fever - II

Case Discussions No 1. History Taking I 2. History Taking II 3. Newborn Screening tests 4. Nutrition in Chronic Disease 5. Approch in Upper Respiratory tract Infection 6. Poisoning 7. Respiratory Problems of the Neonate 8. Primary Heath Care 9. Upper Gastro intestinal bleeding 10. Chronic Diarrhea 11. Tetralogy of Fallot 12. Aort Coarctation 13. Chest Pain 14. Genetic Counselling 15. Psyrosocial Problems 16. Prenatal Diagnosis 17. Tuberculosis Treatment 18. Approach in frequent infection

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 69/125 19. Differantial Diagnosis Inflammatory Disease 20. Differantial Diagnosis in Non-inflammatory D. 21. Hyperbilirubinemia 22. Prematurity 23. Cough, case presentations 24. Approach to prolonged fever 25. Anaphylaxis 26. Anemia 27. Salt Losing Syndrome 28. Short Child 29. Tumor 30. Leukemia 31. Thrombosis 32. Bleeding 33. Dehydration 34. Nephrotic Syndrome 35. Nephritic Syndrome 36. Urinary Infection 37. Vaccination practices 38. Enurezis 39. Guillain Barre Syndrome 40. Urine Analysis 41. 42.

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 70/125 Gynecology and Obstetrics Head of Department: Prof. Dr. Velittin Yedigöz Phone: +902124143000/21409 Secretary: +902124143000/21532 E-mail: [email protected]

Semester: 7-8

Credit of Course: 10

ECTS Credit of Course: 10

Clerkship aims and learning outcomes English Clerkship content Definitions: 1 Obstetrics: Pregnancy / delivery 2 Gynecology: female genital tract diseases Content: ensuring pregnancy, during pregnancy and maternal and infant health along with the systemic / regional disease screening, diagnosis and treatment of the female genital tract diseases screening, diagnosis and treatment Course aims Obstetrics and Gynecology knowledge and practical skills to ensure learning Learning Knowledge and skills in the field of obstetrics and gynecology to have. outcomes Teaching methods Interactive lectures, bedside teaching and strategies

Lectures No 1. Introduction to Obst&Gyn and its subdivisions 2. Historical highlights of Obst&Gyn. History of Obs&Gyn in Turkiye 3. Statistics and epidemiology in Obs&Gyn 4. Embryology and developmental defects of female reproductive tract 5. Anatomy of the female genital tract: Gross anatomy,microscopic anatomy 6. Menstruel cycle and its neuroendocrine control (Hormone biosynthesis, metabolism and mechanism of action 7. The patient in Obst&Gyn.History, physical examination and methods 8. Physiology and development of fetus and adnexes I 9. Physiology and development of fetus and adnexes II 10. Maternal Physiology throughout pregnancy 11. Abortion and early pregnancy losses 12. Antenatal follow-up 13. Assessment of fetal well-being and its methods 14. Normal Labor and Delivery I (Mechanism and Conduct of labor) 15. Normal Labor Labor and Delivery II (Obstetric analgesia and and anesthesia) 16. Normal Labor Labor and Delivery III (Newborn resuscitation) 17. Drugs,physical and chemical exposures during pregnancy and lactation 18. Ultrasonography in Obs&Gyn 19. Preterm labor and premature rupture of the membranes, Intrauterine growth restriction 20. Dystocia, fetopelvic dysproportion, abnormal uterine action of labor 21. Breech,deflexion presentations and transverse lying 22. Operative delivery, birth trauma and treatment 23. Bleeding in the late pregnancy:Placenta previa and plecantal abruption 24. Abnormalities of placenta, Membranes and fetus- Gestational trophoblastic Disease 25. Hemolytic Disease of the Newborn (Rh isoimmunisation) 26. Multiple pregnancy

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 71/125 No 27. Diabetes and pregnancy 28. Hypertension and pregnancy, Preeclampsia 29. Postpartum bleeding and obstetric shock 30. Systemic diseases and pregnancy I (Other diseases due to pregnancy) 31. Systemic diseases and pregnancy II (Coincidentalmedical and surgical disorders) 32. Amenorhea 33. Abnormal Gynecological Bleeding 34. Ectopic pregnancy (Eccyesis) 35. Puerperium 36. Infections of reproductive tract and sexually transmitted diseases 37. Hirsutism and PCOD 38. Disorders of menstruation and other gynecologic endocrine disorders 39. Infertility I (General) 40. Infertility II (Infertile Couple;Male and Female)Reproductive Endocrinology and Assisted Reproductive Techniques) 41. Infertility III (Reproductive Endocrinology) 42. Infertility IV (Diagnostic and therapeutic aspects) 43. Infertility V (Assisted Reproductive Techniques) 44. Pelvic support defects and its treatment/Gynecological urology 45. Benign Lesions of vulva, vagina and cervix 46. Benign Lesions of uterus, tubes and ovaries 47. Gynecological surgery 48. Family Planning I (General Aspects) 49. Family Planning II ( Contraceptive Methods) 50. Endoscopic Surgery 51. Puberty and its disorders, adolescence 52. Climacterium, senium, menopause and its management 53. Endometriosis 54. Gynecologic cytopathology and general aspects of cancerology (Oncology I) 55. Premalignant lesions of the genital tract (Oncology II) 56. Malignant Lesions of Vulva and Vagina (Oncology III) 57. Malignant Lesions of Cervix (Oncology IV) 58. Premalignant and Malignant Lesions of Uterine Corpus (Oncology V) 59. Malignant Lesions of Fallopian Tubes and Ovaries (Epithelial) (Oncology VI) 60. Malignant Lesions of Ovaries (Sex cord stromal and germ cell,Choriocarcinoma) (Oncology VII) 61.

Case Discussions No 1. Contraceptive Methods and Devices 2. Acute Abdomen and Rupture of Ovarian Cysts 3. Precancerous Changes in Endometrium and Treatment 4. Equipment used in Gynecological Examination 5. Fetal Diagnosis and Treatment 6. Stress Incontinence 7. Gynecological Examination Methods 8. Premenopausal Transition and Menopause 9. Differentiation of Ex tema I Genitalia and Repercussions 10. Obstetrical Examination 11. Leiomyomas 12. Hirsutism 13. Multiple Pregnancies 14. Growth Retardations 15. Management of Ovarian Tumors and Treatment

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 72/125 16. Bleedings in Late Pregnancy: Placenta previa and Ablatio Placenta 17. Screening and Diagnosis in Gynecological Cancers 18. Abnormal Presentations 19. Non-menstrual Bleeding 20. Difficult Labor 21. Ectopic Pregnancy 22. Operative deliveries 23. Diagnosis and Treatment of Pelvic Inflammatory Disease: What to do? 24. Cervical Lesions 25. Vaginal Discharges 26. Genetics in Gynecology 27. Diagnosis and Treatment of Vulvar Precancerous Lesions 28. Genital Organ Prolapse 29. Normal Vaginal Delivery 30. Breast Examination 31. Uterine factors in Abortions 32. Dysmenorrhea and Premenstrual Tension 33. Hemorrahgias 34. Fetal Abnormalities 35. Preterm Labor 36. Premature Rupture of the Membranes 37. Abortions 38. Puerperium and manaqement

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 73/125 General Surgery Head of Department: Prof. Dr. Ertuğrul Göksoy Phone: +902124143000/21900 Secretary: +902124143000/21385 E-mail: [email protected]

Semester: 7-8

Credit of Course: 10

ECTS Credit of Course: 10

Clerkship aims and learning outcomes English Clerkship content In this program subjects of diseases included in general surgery are given therotically and supported with clinical applications. Course aims During the clerkship, sufficient informations are given to students about diseases of gastro-intestinal, hepato-pancretico-biliary and endocrine system, breast diseases, abdominal wall hernias, organ transplantation , emergency surgery and trauma diseases. Students, who are the practitioner doctors of future, are also prepared to gain the ability of diagnosing and treating the ordinary patients at first level medical centers and direct the complicated patients to the advanced centers Learning At the end of clerkship period, student should obtain the history of patient, outcomes recognize and interprete the symptoms and signs of the disease, know the diagnostic and therapeutic methods and list the diseases in differantial diagnosis. Student must have an ability to diagnose and treat the ordinary patient at first level medical centers and distinguish the right patient who will be send to 2. and 3. level medical centers. Teaching methods Teaching methods and strategies in clerkship of general surgery includes lectures and strategies and case presentations given by academic members, presentations prepared by students, clinical rounds, practical applications on hospitalized and outpatient patients.

Lectures No 1. Introduction to surgery, principles, history of surgery 2. Evidence- based surgery 3. History and physical examination in surgery 4. Wound healing and management 5. Asepsis, antisepsis and disinfection 6. Surgical infection and usage of antibiotics 7. Metabolic and endocrine response to injury 8. Bleeding, hemostasis blood transfusion, and its complications 9. Shock 10. Fluid and electrolyte, acid-base inbalance and treatment 11. Surgical metabolism and nutrition 12. Surgical instruments and materials 13. Minör surgical procedures 14. Surgical techniques 15. Surgical endoscopy 16. Preoperative management 17. Postoperative complications and patient care 18. Principles of surgical oncology

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 74/125 No 19. Organ transplantations 20. History taking, symptoms, physical examination, and diagnostic methods in breast diseases 21. Benign breast diseases ( Masses, cysts, mastalgia, nipple discharge, breast infections ) 22. Breast carcinoma: Symptoms and diagnosis 23. Treatment of breast carcinoma 24. Goitre and thyroiditis 25. Hyperthyroidism 26. Thyroid carcinoma 27. Parathyroid diseases 28. Adrenal diseases 29. Acute abdominal pain 30. Acute abdomen 31. Gastrointestinal bleedings 32. Bowel obstructions 33. Gastrointestinal fıstulas 34. Approach to trauma patient 35. Abdominal injuries 36. Motility disorders of esophagus 37. Esophageal tumors 38. Gastroesophageal reflux and hiatal hernia 39. Morbid Obesity 40. Surgical treatment of peptic ulcer and its complications 41. Esophageal perforations, burns and foreign body 42. Gastric tumors 43. Small bowel tumors (Bening-malingnant) 44. Acute appendicitis 45. Peritonitis and intraabdominal abscess 46. Short bowel syndrome, Meckel diverticulum, radiation enterocholitis 47. Diseases of the mesenterium, retroperitoneum and omentum 48. Abdominal compartment syndrome 49. Inflammatory bowel diseases 50. Colorectal polyps, polyposis syndromes 51. Diverticular diseases of the colon 52. Colonic carcinoma 53. Rectal carcinoma 54. Diseases of the anal region (Tumors, anal incontinence, rectal prolapsus) 55. Hemorrhoidal disease 56. Perianal abscess, fîstula and anal fissure 57. Pilonidal sinüs 58. Inguinal hernias (Inguinal-femoral) 59. Abdominal wall and incisional hernias 60. Biliary stoııes and their complications 61. Acute and chronic cholecystitis 62. Extrahepatic cholestasis 63. Principles of liver surgery 64. Liver tumors (Benign, malignant, and metastatic) 65. Tumors of gallbladder and biliary tract 66. Pancreatic tumors 67. Hydatid disease of liver 68. Liver abscesses and non-parasitic cysts 69. Acute pancreatitis 70. Chronic pancreatitis 71. Portal hypertension 72. Splenic diseases

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 75/125 Case Discussions No 1. Thyroid nodule 2. Goiter 3. Lump in the Neck 4. Axillary mass 5. Breast lump 6. Nipple discharge 7. Acute abdomen 8. Acute abdominal pain ( Upper quadrants) 9. Acute abdominal pain (Right lower quadrant) 10. Acute abdominal pain (Left lower quadrant) 11. Postoperative acute abdomen 12. Abdominal mass 13. Abdominal mass ( Upper quadrants) 14. Abdominal mass (Right lower quadrant) 15. Abdominal mass (Left lower quadrant) 16. Jaundice 17. Liver mass 18. Dysphagia 19. Haematemesis 20. Melaena 21. Rectal bleeding 22. Bowel obstruction 23. Abdominal distension 24. Constipation 25. Perianal paiıı 26. Perianal swelling 27. Bulge in the groin area 28. Scrotal mass-acute pain 29. Multitrauma patient 30. Abdominal trauma

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 76/125 Radiology Head of Department: Prof. Dr. İsmail Mihmanlı Phone: +902124143000/21951 Secretary: +902124143000/21209 E-mail: [email protected]

Semester: 7-8

Credit of Course: 3

ECTS Credit of Course: 3

Clerkship aims and learning outcomes Clerkship content Radiology clerkship designed to familiarize students with the interpretation of medical images, as well as to provide opportunities for observation in various subspecialty areas of radiology. Course aims The goal of clerkship (Diagnostic Radiology) is to teach the fundamental principles of interpreting radiographic studies. The medical student will learn the value and limitations of such studies in commonly encountered clinical problems. The concept of what constitutes an adequate radiographic study will be examined. An introduction to the principles of radiation protection and the public health implications of diagnostic radiation will also be discussed. Learning A specialty clerkship provides further experience for students considering a career outcomes in radiology or other specialties. Opportunities are provided for students to visit the clinical areas of the various radiology subspecialties and work on the day-to-day diagnostic problems encountered by clinicians. Teaching methods Lectures: Students will be scheduled in various clinical reading rooms in the and strategies morning, where they will be expected to independently assess the radiologic findings of two or three cases and arrive at a defendable interpretation. Whenever possible, differential diagnosis based upon roentgenographic findings will be discussed.

Lectures No 1. Introduction to Radiology 2. Abdominal Radiology 3. GİS Radiology 4. Musculoskeletal Radiology 5. Interventional Radiology 6. Invasive Neuroradiological Procedures 7. Noninvasive Neuroradiological Procedures 8. Breast Radiology 9. Pediatric Radiology 10. Ultrasound – Doppler 11. Chest Radiology Case Discussions No 1. İmaging techniques of lung 2. Pneumothorax 3. Bronchiectasis 4. Biliary tract

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 77/125 No 5. Abdominal Plain Film and CT (normal) 6. İntestinal obstruction (Plain Film+CT) 7. Cruris and knee Plain Film (normal) 8. Cervical costa Plain Film 9. Osteosarcoma of humerus (plain film + MR) 10. Lumbar spondylosis (plain film) 11. Ankylosing spondylitis (plain film ) 12. Cervical spondylitis (MR) 13. Disc protrusion (MR) 14. Zencer‟s diverticulum (Barium graphy) 15. Achalasia (barium graphy) 16. Benign gastric ulcer (barium graphy) 17. Crohn‟s disease (barium graphy) 18. Colon ca (barium graphy) 19. Diverticulosis coli 20. Liver 21. Hepatocellular ca (CT) 22. Splenic subcapsular hematoma 23. Liver hemangioma (CT) 24. Renal cyst and tm (CT) 25. Renal cell ca 3D CT 26. Gallbladder stone (Plain film + US) 27. I.V.P. (normal) 28. Renal angiography (normal) 29. Abdominal DSA 30. Epidural,acute subdural,subdural hematoma CT 31. Subarachnoid, parenchymal hemorrhage 32. Brain artefacts (CT) 33. MCA İnfarkt (CT) 34. Breast invaziv ductal ca (mammography) 35. Breast tm ,cyst (US-MR) 36. Ankylosing spondylitis 37. Osteosarcoma 38. Perthes' disease 39. Hyperparathyroidism 40. Congenital developmental dysplasia of the Hip 41. İmaging techniques of lung 42. Pneumothorax 43. Bronchiectasis 44. Biliary tract 45. Abdominal Plain Film and CT (normal) 46. İntestinal obstruction (Plain Film+CT) 47. Cruris and knee Plain Film (normal) 48. Cervical costa Plain Film 49. Osteosarcoma of humerus (plain film + MR) 50. Lumbar spondylosis (plain film) 51. Ankylosing spondylitis (plain film) 52. Cervical spondylitis(MR) 53. Disc protrusion(MR) 54. Zencer‟s diverticulum (Barium graphy) 55. Achalasia (barium graphy) 56. Benign gastric ulcer (barium graphy) 57. Crohn‟s disease (barium graphy) 58. Colon ca (barium graphy) 59. Diverticulosis coli 60. Liver 61. Hepatocellular ca (CT)

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 78/125 No 62. Splenic subcapsular hematoma 63. Liver hemangioma (CT) 64. Renal cyst and tm (CT) 65. Renal cell ca 3D CT 66. Gallbladder stone (Plain film + US) 67. I.V.P. (normal) 68. Renal angiography (normal) 69. Abdominal DSA 70. Epidural,acute subdural,subdural hematoma CT 71. Subarachnoid, parenchymal hemorrhage 72. Brain artefacts (CT) 73. MCA İnfarkt (CT) 74. Breast invaziv ductal ca (mammography) 75. Breast tm ,cyst (US-MR) 76. Ankylosing spondylitis 77. Osteosarcoma 78. Perthes' disease 79. Hyperparathyroidism 80. Congenital developmental dysplasia of the Hip 81. Hamartoma 82. Fibroadenoma 83. Secretuar disease 84. Benign cysts of breast 85. İnvaziv ductal carcinoma 86. Radial scar 87. Insitu ductal carcinoma 88. Metastatic axillary lymph nodes 89. Postoperative scar 90. Multicentric breast carcinoma 91. Metastatic cancer with unknown primary 92. Liver cyst hydatid 93. Liver hemangioma 94. Hepatocellular ca 95. Focal nodular hyperplasia 96. Renal Stone 97. Liver hematoma 98. Renal hematoma 99. Liver hemangioma 100. Appendicitis 101. İnvagination 102. Pyloric stenosis 103. Urinary tract infection 104. Testicular torsion 105. Epididymo-orchitis 106. Hepatoblastoma 107. Portal vein thrombosis 108. Lymphoma 109. Neuroblastoma 110. Lung infection 111. Liver laceration 112. Lung contusion 113. Renal laceration 114. Foreign body in bronchus 115. Corrosive esophageal strictures 116. Constipation 117. Duodenal stenosis 118. Crohn‟s disease

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 79/125 No 119. Hirschsprung 120. Vesicoureteral reflux (VUR) 121. Subclavian stenosis; PTA 122. Fibromuscular Dysplasia (FMD), right renal artery stenosis PTA 123. Thorocoabdominal aortic stenosis in a 9-month-old infant 124. Carotid stent 125. Left renal artery stent 126. Bilateral renal artery stent 127. Right common iliac artery occlusion , stent (contralateral approach) 128. Left SFA occlusion ; stent 129. Fibrosing mediastinitis; SVC occlusion, treatment with stent 130. Left external iliac artery aneurysm, cover stent 131. Acute transsection 132. İnfrarenal abdominal aortic aneurysm,treatment with endograft 133. Aneurysmal bone cyst of right humerus;embolization 134. İliac wing metastasis of malign melanoma; preoperative devascularization 135. Cervix ca; vaginal hemorrhage,tumoral devascularization 136. Right groin AVM; embolization with onyx 137. High-flow priapism; embolization of pudental pseudoaneurysm 138. Behcet disease, Hemoptysis embolization with NBCA (histoacryl) Postpartum hemorrhage; subtotal hysterectomy 139. Pseudoaneurysm embolization 140. Right PFA post-traumatic pseudoaneurysm embolization with onyx 141. Post biopsy intrarenal pseudoaneurysm embolization with NBCA 142. HCC, Chemoembolization 143. Vena cava filter 144. Biopsies 145. Lytic expansile lesion in sacrum 146. Sclerotic lesion in distal femur, high grade osteosarcom 147. Lytic lesion in iliac wing; aneurysmal bone cyst 148. Lytic destructive soft tissue mass in thoracic vertebra Chronic renal failure, hemodialysis patient, ossified mass in forearm, ossification related to 149. hyperparathyroidism,FNAB; pilomatrixoma 150. Necrotizing granulomatous infection TB 151. İliac bone post destruction and soft tissue mass ,folliculer ca metastasis 152. C5 destructive mass 153. Thyroid mass,destructive scapular mass 154. Lytic lesion in lumbar vertebrae Carcinoma of the ampulla of Vater 155. Percutaneous transhepatic biliary drainage (external) 156. Percutaneous transhepatic biliary drainage (internal) 157. Percutan antegrad nefrostomy 158. RF ablation 159. Cement injection 160. Hemangioma of vertebra 161. Osteoporosis 162. Metastasis 163. Subarachnoid hemorrhage 164. Epidural hematoma 165. Subdural hematoma 166. Arteriovenous malformation 167. Cerebrovascular event 168. MRI 169. CT 170. RDUS 171. DSA 172. Congenital metabolic disease

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 80/125 No 173. Hypoxic ischemic encephalopathy 174. Esophagus barium graphy 175. Anatomy of esophagus, primary and secondary wave 176. Esophageal diverticula ,real diverticula, pseudodiverticula 177. Complication of diverticula 178. Functional motility disorder of esophagus Primary disorders ;Acalasia, Chalasia, Nutcracker 179. Esophagus, Diffuse esophageal spasm, Presbyesophagus, Tracheo-esophageal fistula Secondary disorders; Connective tissue disorders, reflux esophagitis,caustic esophagitis, 180. vagotomy, radiotherapy, infectious esophageal disorders Esophagitis;bacterial esophagitis ,viral esophagitis,fungal esophagitis,reflux esophagitis, 181. caustic esophagitis 182. GER, Grade I, Grade II ,Grade III 183. Reflux esophagitis 184. Barrett esophagus,ulcer,fibrosis,mucosal traction,intramural divertikulosis 185. Esophageal webb, Plummer-Vinson Syndrome Neoplastic processes;mukosal (papilloma,polip,cancer),submucosal 186. (Leiomyoma,Lipoma,Hemangioma,Neurofibroma), Extrensek (ekstrensek tumoral process) 187. Esophagus ca (squamous,adeno ca) 188. Esophagus ca morfologic types(polipoid,ulcerous,annular,mixt,varicoid) 189. Submucosal tm Algoritm for disfagia(esophagus barium graphy if neoplastic sign exist ; endoscopy +biopsy Stage first choise CT ,second choise MR ,third choise for early stage tumor 190. endosonography) 191. Stent aplication (inop esophagus ca, palliative treatment of fistula) 192. Normal double contrast stomach graphy 193. Bezoar,phytobezoar,trichobezoar 194. Hiatal hernia (sliding,rolling, congenital hiatal hernia; morgagni , bochdalek) 195. Benign ulcer 196. Malign ulcer 197. Early gastric ca and classsification 198. Gastric tumors a)Mucosal gastric tumors(hyperplastic polip, hamartomatous polip, adenoma,retantion 199. polips,adenocancer) b) Submucosal gastric tumors(Leiomyoma, Neurofibroma, Lipoma, Hemangioma, 200. Leiomyosarcoma, Neurofibrosarcoma, Liposarcoma, Hemangiosarcoma, Lymphoma) 201. Gastric ca (ulcerovegetan type,polipoid type ulcerous type ,infiltrative type) 202. Primary GIS lymphoma criteria 203. Primary lymphoma localization 204. The most common localization of lymphoma is stomach 205. Small bowel localization is rare 206. Small bowel radiologic imaging (enteroclysis,small bowel barium graphy) 207. Normal small bowel anatomy 208. Meckel diverticulum 209. CT enteroclysis, MR enteroclysis 210. Malabsorption syndrome 211. a)İntestinal (celiac,whipple,short bowel syndrome giardiasis, amyloidosis) b)Extraintestinal (pancreatic enzyme deficiency,gallbladder diseases, İmmerslund- 212. Grasbeck syndrome, drugs) 213. Radilogic findings of Celiac diseases 214. İntestinal diverticulosis coli İntestinal adhesion and brids(serosal adhesion, angulasyon, tenting,brid formation,gatto 215. formation) 216. Small bowel tumors Primary intestinal lymphoma types(polipoid,multiple nodular,circumferential segmenter 217. aneurysmatic,endoexoenteric with cavitation and fistula,mesenteric and mixt )

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 81/125 No Polyposis syndromes(herediter multiple polyposis Peutz-Jeghers syndrome, Gardner syndrome, Turcot syndrome, Crohnkide-Canada, 218. Juvenil polyposis, Cowden disease 219. Adenomas,adenocancer,carcinoid tm 220. Metastatic tumors of small bowel(hematogenic,direct invasion,peritoneal implantation) 221. inflammatory bowel disease a) Crohn's disease(aftous ulcer,ulceronodular pattern,complications,strictures,fistula 222. ,abscess formation) b)Extraintestinal findings of Crohn's disease(arthritis, sacroileitis and ankylosing spondylitis, sclerosing cholangitis, cholangiocarcinoma, cirrhosis, granulomatous hepatitis, amyloidosis, 223. ürolithiasis, episcleritis, pyoderma gangrenosum,thromboembolic events) Ulcerative colitis(mucosal granularity,pseudopolip formation,polips and ca ,”lead pipe” 224. appearance, Backwash ileitis, toxic megacolon) Crohn's disease (asymmetric involvement, scip area,right hemicolon,deep spicular 225. ulcers,fistulas, abscess formation) Ulcerative colitis (consantric involvement, continue involvement,submucous hollow 226. ulcers,”lead pipe”appearance, toxic megacolon 227. Differential diagnosis depend on the pathologic findings 228. Tuberculosis 229. Ischemic bowel diseases 230. Normal colon anatomy 231. Congenital aganglionic megacolon 232. Diverticular diseases, diverticulitis 233. Polip (flat,spheric ,pedinculated 234. Benign –malign differentiation 235. Colon ca ( first choice CT) 236. Duke's classification İmaging techniques; chest radiography,conventional tomography, 237. fluoroscopy,CT,HRCT,MR,USG Chest radiography,PA graphy,lateral graphy,lateral decubitus graphy, apicolordotic 238. graphy,oblique graphy 239. Chest film;PA film,AP film,technique and positional situations 240. Diaphragma 241. Plevra ,pulmoner fissurs,pulmoner sinus 242. Mediastinum;right contour ,left contour Lateral radiography(retrosternal,retrocardiac area, aortopulmoner window,vertebral 243. radiolucency,posterior tracheal wall,sternum,vertebrae, diaphragma,fissurs 244. Aortopulmoner window 245. Chest radiography 246. CT (sectional imaging) 247. How should optimal CT be ? 248. Sectional anatomy (mediastinum window, parenchym window) 249. Advantages of CT 250. HRCT Thoracal MR(mediastinum mass ,vascular pathologies ,lung ca staging, parenchymal 251. assesment 252. Hilar expansion 253. Anterior mediastinum 254. Middle mediastinum 255. Posterior mediastinum

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 82/125 Anesthesiology and Reanimation Head of Department: Prof. Dr. Fatiş Altındaş Phone: +902124143000/22489 Secretary: +902124143000/21876 E-mail: [email protected]

Semester: 7-8

Credit of Course: 2

ECTS Credit of Course: 2

Clerkship aims and learning outcomes Clerkship content Anaesthesia techniques, drugs used in anaesthesia practice, regional anaesthesia, pain treatment, critical illness, foundations of critical care and cardiopulmonary resuscitation are thought with thematic lectures and clinical practices carried by academic staff. Course aims Obtain information on anaesthesia and intensive care,learn to define critically ill patient who needs urgent care, learn pain mechanisms and pain treatment, apply advanced life support. Learning 1. Defines anaesthesia outcomes 2. Defines general anaesthesia indications and application methods 3. Can discuss uptake and distribution of inhalational anaesthetics and defines MAC 4. Can list four complications which can be seen during anaesthesia 5. Can list regional anaesthesia techniques 6. Can define the pharmacologic features of local anaesthetics 7. Defines physiological basis of intracranial pressure and pathophysiology of iotracranial hypertension 8. Can define trauma and list mechanisms of trauma. Defines primary evaluation and resuscitation of trauma victim 9. Can specify the tasks of anaesthesiologist in trauma team 10. Can list sepsis criteria completely and diagnose severe sepsis 11. Can diagnose a patient with respiratory insuffıciency 12. Can define the initial resuscitation of sepsis patient 13. Can list the criteria of acute respiratory distress syndrome (ARDS) 14. Can evaluate blood gas and acid base measurements 15. Defines the uptake and transport of oxygen, defines oxyhaemoglobin dissociation curve, and lists the factors shift in the curve to left or right 16. Defines oxygen treatment indications and application methods 17. Can list the indications and complications of blood component transfusions 18. Can specify the fluid compartments, defines hypovolemia and hypervolemia and lists the clinical findings of these events 19. Can diagnose electrolyte imbalances and specify the importance ofthese for anaesthesia 20. Defines pain mechanisms 21. Can specify the principles of treatment of pain 22. Can apply advanced life support on manikin 23. Can apply emergency treatment in hypothermia, anaphylaxis and near drowning 24. Can specify principles of clinical nutrition 25. Can list the important features of initial evaluation of unconscious patient 26. Defines the initial therapy in intoxicated patient 27. Defines the concepts of death, somatic death and brain death 28. Knows that traditional deathand brain death ara similar 29. Diagnose brain death and knows the tests for brain death

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 83/125 30. Knows the aethiology and pathophysiology of brain death 31. Knows the lagal framework of organ donation in the country.

Teaching methods Classes and clinical practice and strategies

Lectures No 1. Introduction / information 2. Basic Life Support 3. Oxygen transport and oxygen therapy 4. Advanced Life Support and cardiac arrest scenarios 5. General anesthesia and postoperative complications

6. Fluid and electrolyte disorders and treatment 7. Arterial blood gases, acid base disorders 8. Acute respiratory failure 9. Anaphylaxis, near drowning and hypothermia 10. Transfusion of blood and blood components 11. Management of unconscious patient 12. Management of trauma patient 13. Local anesthetics 14. Regional anesthesia 15. Pathophysiology of pain 16. Assessment of pain and therapeutic approaches 17. Intoxications 18. ARDS 19. Sepsis 20. Intracranial pressure in traumatic brain injury 21. Basic concepts in clinical nutrition 22. Brain death and organ donation 23. Pediatric physiology and pediatric anaesthesia

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 84/125 Urology Head of Department: Prof. Dr. Nur Ahmet Erözenci Phone: +902124143000/21928 Secretary: +902124143000/21011 E-mail: [email protected]

Semester: 7-8

Credit of Course: 5

ECTS Credit of Course: 5

Clerkship aims and learning outcomes Clerkship content Familarity about approaches to urological diseases. Course aims To teach Symptomatology and diagnostic pathways in urological diseases. Learning Knowledge on when to forward the patient to a urologist Experience as a GP in outcomes the management of urologic patients. Teaching methods Seminars, case presentation, bedside teaching and strategies Lectures No 1. Introduction to urology 2. Patient-physician relationship 3. History taking 4. Physical examination 5. Urological emergencies 6. Urological surgical emergencies in the view of general practitioner 7. Cystic diseases of the kidney 8. Introduction to urooncology 9. Uroepithelial tumours 10. Tumors of the kidney 11. Bladder and renal cancers in the view of general practitioner 12. Anomalies of the GU system 13. Vesico ureteral reflux 14. Benign Prostate Hyperplasia 15. Male infertility 16. Infections of the GU system 17. Ethical considerations 18. Adjunct fertility methods in infertile patients, when, how? 19. Prostate cancer 20. Testicular tumors 21. PSA elevation 22. Physiology of erection 23. Erectile dysfunction 24. Peyronie disease, diagnosis and treatment 25. Premature ejeculation, diagnosis and treatment Case Discussions No 1. History taking 2. Physical examination methods 3. Evaluation of symptomatology 4. Case study: stone disease

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 85/125 No 5. Case study: BPH 6. Case study: incontinence 7. Case study: Scrotal diseases 8. Case study: andrology 9. Case study: instrumentation in urology 10. Case study: infertility 11. Case study: endourology 12. Case study: pediatric urology 13. Case study: uroepithelial carcinoma 14. Case study: prostate cancer

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 86/125 5th Year Clerkships  Orthopedics and Traumatology (3 weeks)  Psychiatrics (2 weeks)  Neurosurgery (1 week)  Physical Medicine and Rehabilitation (3 weeks)  Neurology (3 weeks)  Ophthalmology (3 weeks)  Otorhinolaryngology (3 weeks)  Pulmonary Medicine (3 weeks)  Cardiovascular Surgery (2 weeks)  Thoracic Surgery (1 week)  Pediatric Surgery (2 weeks)  Radiation Oncology (1 week)  Plastic Surgery (2 weeks)  Nuclear Medicine (1 week)  Cardiology (3 weeks)  Infectious Diseases (3 weeks)  Forensic Medicine (2 weeks)  Public Health (2 weeks)  Dermatology (2 weeks) Total: 42 weeks.

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 87/125 Orthopedics and Traumatology Head of Department: Prof. Dr. Önder Aydıngöz Phone: +902124143000/21398 Secretary: +902124143000/21338 E-mail: [email protected]

Semester: 9-10

Credit of Course: 4

ECTS Credit of Course: 4

Clerkship aims and learning outcomes Clerkship content The 3 weeks of the Orthopaedics and Traumatology course are intended to provide the clerk with the broad principles of orthopaedic surgery and the basics in the individual orthopaedic surgical specialties as a foundation for pregraduate trainingo Course aims This is a course that provides a wide exposure to inpatient and outpatient orthopaedic surgery ranging from trauma and sports medicine to reconstruction. The student integrates medical, surgical, pathological, and radiological patient information. Patients are evaluated in both the inpatient and outpatient settings. The student is expected to integrate book knowledge with patient care. Learning At the end of this clerkship, students: outcomes 1. Describe the relevant anatomy and pathophysiology of common orthopaedic problems including disorders involving the musculoskeletal system (muscles, bones, joints) and neurologic system (spinal cord, and peripheral nerves). 2. Obtain an accurate, focused history from, and perform an appropriate physical examination of, patients presenting with surgical disorders of the before mentioned systems. 3. Request and interpret the results of appropriate laboratory and imaging investigations for these surgical conditions, while making efficient use of limited resources. 4. Describe the management options and appropriate strategies for treatment of these orthopaedic conditions. 5. Participate in the initial assessment and management of a polytraumatized patient, and Describe the priorities of resuscitation, investigation and treatment. 6. Apply clinical knowledge to recognize and prioritize Iife- and limb-threatening illnesses and perform preliminary assessment ("sick" vs. "not sick”) of undifferentiated emergency patients. 7. Describe and discuss the concept of triage. Teaching methods All clerks entering clerkship will be required to attend daily mandatory teaching and strategies seminars (power point presentations, interactive discussions). Clerks will also be required to attend weekly mandatory policlinic and bed side teaching seminars.

Lectures No 1. Introduction to orthopaedics and traumatology 2. Approach to the trauma patient 3. Classification of fractures 4. Fracture healing 5. Open fractures 6. Bone and joint infections 7. Complications of fractures and dislocations 8. Osteochondroses and Legg-Calvé Perthes Disease 9. Developmental hip dysplasia

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 88/125 No 10. Pediatric fractures 11. Fractures of spine 12. Deformities of the spine 13. Spondylolisthesis and congenital spinal disorders 14. Radiological examination in orthopaedics & traumatology 15. Physical examination of the hip 16. Spinal infections 17. Physical examination of the pediatric patients 18. Fractures of the proximal femur 19. Benign bone lesions 20. Malignant bone tumors 21. Physical examination of the knee 22. Injuries of the knee 23. Injuries around the shoulder and elbow 24. Physical examination of the upper extremity 25. Injuries of the wrist and hand 26. Rotator cuff tears and shoulder instabilities 27. Physical examination of the foot and ankle 28. Injuries of the foot and ankle 29. Foot deformities 30. Foot diseases 31. Congenital club foot 32. Metabolic bone diseases 33. Pelvis fractures and traumatic hip dislocations 34. Connective tissue diseases

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 89/125 Physical Medicine and Rehabilitation Head of Department: Prof. Dr. Halil Koyuncu Phone: +902124143000/21945 Secretary: +902124143000/21759 E-mail: [email protected]

Semester: 9-10

Credit of Course: 4

ECTS Credit of Course: 4

Clerkship aims and learning outcomes Clerkship content Contents: Physical medicine and rehabilititaion methods, rehabilitation team definition of the vocations of the rehabilitation team members, diseases concerning the specialty ( locomotor system as well as chronic disease processes ), physical examination, physical therapy and rehabilitation interventions. Course aims To teach physical medicine and rehabilitation methods, and the comprehensive neurologic, orthopedic and rheumatologic evaluation of a disease involving the muskuloskeletal system. Learning By the end of the the clerkship students should be able to: outcomes 1. Describe the definition of physical medicine and rehabilitation concepts, disease, disfunction, disability and handicap 2. Take a comprehensive patient history, perform a physical examination, diagnose disease, disfunction, disability and handicap, to manage or refere the patient for rehabilitation. Teaching methods Lectures, case presentations, bedside teaching, multidisciplinary meetings and strategies

Lectures No 1. Physical Medicine and Rehabilitation Definitions and Aims: Past, Present and Future 2. Physical Examination of the Spine 3. Physical Examination of the Lower Extremities 4. Physical Examination of the Upper Extremities 5. Degenerative Joint Diseases 6. Shoulder Pain 7. Rehabilitation of Spinal Cord Injury 8. Cervical and Lumbar Disc Herniations 9. Neck Pain 10. Spondyloarthritis 11. Physical Therapy Agents 12. Rehabilitation of Rheumatoid Arthritis 13. Soft Tissue Rheumatism 14. Pediatric Rehabilitation 15. Stroke Rehabilitation 16. Low Back Pain 17. Orthopedic Rehabilitation 18. Osteoporosis

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 90/125 Case Discussions No 1. Diagnostic Approach to the Patient with Back Pain1 2. Diagnostic Approach to the Patient with Back Pain2 3. Diagnostic Approach to the Patient with Arm Pain1 4. Diagnostic Approach to the Patient with Arm Pain2 5. Assessment of the Patient with Osteoporosis 1 6. Assessment of the Patient with Osteoporosis 2 7. Assessment of the Patient with Neck Pain 1 8. Assessment of the Patient with Neck Pain 2 9. Assessment of the Patient with Polyarthritis 1 10. Assessment of the Patient with Polyarthritis 2 11. Assessment of the Patient with Leg Pain 1 12. Assessment of the Patient with Leg Pain 2 13. Assessment of the Patient with Monoarthritis 1 14. Assessment of the Patient with Monoarthritis 2 15. Assessment of the Patient with Generalized Pain1 16. Assessment of the Patient with Generalized Pain 2 17. Assessment of the Patient with Shoulder Pain 1 18. Assessment of the Patient with Shoulder Pain 2 19. Assessment of the Patient with Neck-Arm Pain1 20. Assessment of the Patient with Neck-Arm Pain2 21. Assessment of the Patient with Knee Pain 1 22. Assessment of the Patient with Knee Pain 2 23. Assessment of the Stroke Patient 1 24. Assessment of the Stroke Patient 2 25. Assessment of the Disabled Child Patient 1 26. Assessment of the Disabled Child Patient 2 27. Assessment of the Patient with Low Back Pain 1 28. Assessment of the Patient with Low Back Pain 2 29. Assessment of the Patient with Limited Low Back Motion 1 30. Assessment of the Patient with Limited Low Back Motion 2 31. Assessment of the Paraplegic Patient 1 32. Assessment of the Paraplegic Patient 2 33. Assessment of the Acute Traumatic Patient 1 34. Assessment of the Acute Traumatic Patient 2

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 91/125 Neurology Head of Department: Prof. Dr. Sabahattin Saip Phone: +902124143000/22002 Secretary: +902124143000/21236 E-mail: [email protected]

Semester: 9-10

Credit of Course: 4

ECTS Credit of Course: 4

Clerkship aims and learning outcomes Clerkship content Neurologic Semiology, Neurologic Examination, Principles of Neurologic Diagnosis. Course aims Practical approach to the neurologic patients, principles of neurologic diagnosis according to the presenting symptom of the patient, neurologic examination Learning To make differential diagnosis of the presenting symptoms, to make complete outcomes neurologic examination Teaching methods Lectures, clinical practices, case presentations and strategies

Lectures No 1. Semiology: Motor System 2. Semiology: Sensory System 3. Semiology: Mental Function 4. Semiolgy: Cerebellar System 5. Semiology: Cranial Nerves 6. Epilepsy: Clinic 7. Epilepsy: Diagnosis 8. Epilepsy: Treatment 9. Sleep and it‟s Disorders 10. Sleep and it‟s Disorders 11. Multiple Sclerosis: Clinic 12. Multiple Sclerosis: Diagnosis and Treatment 13. Pediatric Neurology: Epilepsy 14. Pediatric Neurology: Neurodegenerative Disorders 15. Pediatric Neurology: Mental Disorders 16. Neurological Complications of Sys.Disease 17. Cerebrovascular Disease: Ischemic 18. Cerebrovascular Disease: Hemorrhagic 19. Dementia 20. Neuropathies 21. Muscle Disorders 22. Vertigo 23. Neurological Complications of Sys.Disease 24. Primary Headache 25. Sekondary Headache 26. Movement Disorders: Parkinson‟s Disease 27. Movement Disorders: Dystonia and Tremor 28. Movement Disorders: Degenerative Disease 29. Movement Disorders: Treatment

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 92/125 Case Discussions No 1. Neurological Examination 2. Neurological Examination 3. Neurological Examination 4. Neurological Examination 5. Neurological Examination 6. Patients with Epilepsy 7. Patients with Sleep Disorders 8. Patients with Multiple Sclerosis 9. Patients with Epilepsy 10. Patients with Vascular Disease of the Nervous System 11. Patients with Dementia 12. Patients with Neuropathy 13. Patients with Myopathy 14. Patients with Vertigo and Disequilibrium 15. Patients with Headache 16. Patients with Movement Disorders

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 93/125 Neurosurgery Head of Department: Prof. Dr. Galip Zihni Sanus Phone: +902124143000/22455 Secretary: +902124143000/21223 E-mail: [email protected]

Semester: 9-10

Credit of Course: 1

ECTS Credit of Course: 1

Clerkship aims and learning outcomes English Clerkship content Neurosurgery course is carried out in five days. Lectures on main neurosurgical topics are given and clinical practice is carried out by the academic staff. A study- work is given by the academic staff who is responsible for the student is prepared. Course aims The main aim of this course is to deliver the core knowledge of diseases related with neurosurgery, which are most commonly seen during daily medical practice, to the medical students. The learning outcomes are the minimal aim of this course. Planning the appropiate management strategy in emergency cases related with neurosurgey and understanding the importance, that correct decisions in these cases are life saving is another aim. Evaluation and making the differential diagnosis in patients with neurological symptoms is also aimed. Learning 1. Defines Glasgow Coma Scale without any mistakes and uses in clinical outcomes practice 2. Defines at least 3 cardinal signs and symptoms of raised intracranial pressure and cerebral herniation syndromes 3. Defines main concepts of head injury and performs the first evaluation, plans the appropriate transportation of the patient 4. Defines the main concepts of spinal trauma and facilitates the transportation accurately 5. Lists the brain tumors according to the age and location and also defines the clinical signs, plans the radiological investigation; lists the current treatment options 6. Defines the clinical findings and reasons of hydrocephalus in different age groups, lists the treatment options 7. Defines major congenital neurosurgical pediatric malformations and stresses their clinical importance 8. Can correctly diagnose the clinical findings of the subarachnoid hemorrhage and transports appropriately to an upper level medical center 9. Can discuss the differential diagnosis of lumbar disc herniation, plans the radiological investigations and lists the definitive surgical indications Teaching methods Lectures (Power point presentations), video presentations, interactive discussions, and strategies bed-side teaching and mini-clinical evaluation, after the examination evaluation of the course and the examination

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 94/125 Lectures No 1. Introduction to Neurosurgery and Guidelines of the Course 2. Functional Neuroanatomy and Clinical Neuroradiology 3. Cerebral Edema and Raised Intracranial Pressure 4. Head Injury Part I 5. Congenital malfomations and Craniosynostozis 6. Hydrocephalus 7. Brain Tumors Part I 8. Brain Tumors Part II 9. Cerebrovascular Diseases 10. Spinal Degenerative Diseases 11. Spinal Tumor 12. Spinal Trauma 13. Peripheral Nerve Surgery 14. Central Nervous System Infections 15. Epilepsy and Functional Surgery Case Discussions No 1. Lumbar Disc Herniation 2. Cervical Disc Herniation 3. Head Injury – Epidural Hematoma 4. Brain Tumor – Glial Tumor 5. Brain Tumor – Meningioma 6. Raised Intracranial Pressure 7. Hydrocephalus 8. Meningomyelocele and Tethered Cord 9. Spinal Tumor 10. Carpal Tunel Syndrome 11. Subarachnoid Hemorrhage 12. Intracerebral Hematoma 13. Spinal Infection 14. Arteriovenous Malformation 15. Epilepsy 16. Cerebello – Pontine Angle Tumor 17. Posterior Fossa Tumor 18. Spinal Trauma 19. Trigeminal Neuralgia 20. Head Injury – Subdural Hematoma 21. Head Injury – Multipl Trauma 22. Intracranial Abscess 23. Pituitary adenoma – Micro 24. Pituitary adenoma – Macro

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 95/125 Psychiatry Head of Department: Prof. Dr. Alaattin Duran Phone: +902124143000/22004 Secretary: +902124143000/21768 E-mail: [email protected]

Semester: 9-10

Credit of Course: 3

ECTS Credit of Course: 3

Clerkship aims and learning outcomes English Clerkship content Basic skills on approach to the psychiatric patient are aimed to be achived Course aims 10. The genetics, neurobiology, clinical presentations, and diagnostic criteria, treatment algorhythms about psychiatric disorders 11. In addition, knowledge about relationship between psychiatric ilnesses and general medical conditions, interaction between psychopharmacological drugs and drugs due to general medical conditions is aimed to be achived. 12. Skills about approaching to emergent psychiatric patients, information about contemporay therapies are aimed to be taught Learning Handling a psychiatric patient from initation to the conclusion such as: diagnose, outcomes differential diagnose,knowing how and where to treat is aimed to be achieved. Teaching methods Lectures and clinical practices. and strategies

Lectures No 1. Introduction to Psychiatry (Neurobiological Approach) 2. Introduction to Psychiatry (Dynamic Approach) 3. Introduction to Psychiatry (Defense mechanisms) 4. Psychiatric İnterview and examination 5. Psychiatric signs 6. Schizophrenia 7. Other Psychotic Disorders 8. Psyhologic Factors Effecting Medical Conditions 9. Somotoform Disorders 10. Eating and Sleeping Disorders 11. Anxiety Disorders 12. Sexual Disorders 13. Psychiatric Disorders Due To Alcohol 14. Psychiatric Disorders Due To Substance abuse 15. Impulse Control Disorders 16. Affective Disorders 17. Personality Disorders 18. Dissociative Disorders 19. Social Psychiatry 20. Factitious Disorders and Malingering 21. Delirium, Demantia (Geropsychiatry) 22. Emergency Psychiatry 23. Forensic Psychiatry 24. Treatment in Psychiatry 25. Psychotherapies 26. Child and Adolescent Psychiatry

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 96/125 Case Discussions No 1. Psychosis 2. Bipolar depression 3. Differential Diagnosis in Bipolar Disorder 4. Neurosis (Generalized Anxiety + Panic Attack + OCD ) 5. Delirium + Dementia 6. Bipolar Disorder in elderly 7. Psychosis in elderly

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 97/125 Ophtalmology Head of Department: Prof. Dr. Güzin İskeleli Phone: +902124143000/21116 Secretary: +902124143000/21117 E-mail: [email protected]

Semester: 9-10

Credit of Course: 4

ECTS Credit of Course: 4

Clerkship aims and learning outcomes English Clerkship content To teach the diagnosis and differential diagnosis of the major ocular diseases and the treatment of some of them Course aims To teach the diagnosis and differential diagnosis of the major ocular diseases and the treatment of some of them. Learning Observation of the specialist doctor in subspecialty clinics while they are working outcomes on the patients. Also observation of different surgeries from the video camera system Teaching methods Lectures, Observation of live surgery, video, case presentations, bed-side and strategies teaching. Lectures No 1. Anatomy- Phvsiology 2. Refractive Errors 3. Methods of Examination 4. Strabismus 5. Orbital Diseases 6. Lachrymal Diseases 7. Lasers 8. Conjunctival Diseases 9. Contact Lenses 10. Lens Diseases 11. Corneal Diseases 12. Macular Diseases 13. Disorders of Retina I (Retinal Vascular Diseases) 14. Optic Nerver Diseases 15. Lid Disorders 16. Nystagmus 17. Tumors of the eye 18. Disorders of Retina II (Retinal Detachment) 19. Glaucoma I (Primary Open Angle Glaucoma) 20. Uveal Diseases 21. Glaucoma II (Congenital Glaucoma) 22. Red Eye 23. Acute Glaucoma

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 98/125 Case Discussions No 1. Viral and bacterial conjunctivitis 2. Uveitis 3. Congenital glaucoma 4. Strabismus 5. Central and branch retinal vein occlusions 6. Macular edema 7. A case of exotropia and esotropia Dacryocyctitis 8. Keratoplasty (penetrating, lamellar) Cataracts (congenital, senil) Keratitis 9. Primary open angle glaucoma Juvenil glaucoma Ocular hypertension Acute glaucoma 10. Retinal detachment 11. Thyroid ophtalmopathy Optic neuropathy 12. Allergic conjunctivitis 13. Diabetic retinopathy 14. Expulsive hemorrhage

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 99/125 Otorhinolaryngology Head of Department: Prof. Dr. Özgün Enver Phone: +902124143000/21871 Secretary: +902124143000/21520 E-mail: [email protected]

Semester: 9-10

Credit of Course: 4

ECTS Credit of Course: 4

Clerkship aims and learning outcomes English Clerkship content Diagnosis and treatment of diseases of ear, throat, nose, head and neck. Contents: Diagnosis and treatment methods, definition of the vocations of the ENT team members, diseases concerning the speciality , physical examination, medical and surgical treatment. Course aims To acquire skills to examine, diagnose and treat ENT diseases Learning At the end of the ENT rotation the students should learn the definition of the ENT outcomes concepts, diseases, physical examination methods and treatments, how to take comphrensive patient history, perform physical examination, diagnose and treat ENT disesase Teaching methods Lectures,case reports,bed-side teaching,multidisciplinary meetings and strategies

Lectures No 1. Anatomy of the ear 2. Physiology of hearing 3. Infectious and inflammatory diseases of the ear 4. Otogenous complications 5. Diseases of the external ear 6. Basic Odiology 7. Development of hearing and language in children 8. Rehabilitation in hearing and language disorders 9. Infectious diseases of middle ear 10. Otogenous complications 11. Hearing loss 12. Treatment of hearing loss 13. Vestibuler system physiology and disorders 14. Anatomy and physiology of the nose and paranasal sinuses 15. Allergy and ENT 16. Infections of nose and PNS 17. ENT Emergencies I 18. ENT Emergencies II 19. Esthetic and reconstructive surgery in ENT 20. İnfectious and inflammatory diseases of the Salivary Glands 21. Benign and Malignant Tumors of the Salivary Glands 22. Facial paralysis 23. Sore throat and infectious-inflammatory Diseases of the oral cavity and pharynx I 24. Sore throat and infectious-inflammatory Diseases of the oral cavity and pharynx II 25. Snoring and OSAS 26. Anatomy of the neck and approach to neck masses

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 100/125 No 27. Physiology and Anatomy of the Larynx 28. Malignanat neoplasia of the larynx 29. Hoarseness and inflammatory diseases of the larynx 30. Benign disorders of the larynx 31. Paralysis of the larynx 32. Tumors of the nasaopharynx 33. Deep neck space infections 34. Thyroid and Parathyroid Diseases-I 35. Thyroid and Parathyroid Diseases-II 36. Noplasia of the oral cavity, oropharynx and hypopharynx 37. Neoplasia of the Nose and PNS

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 101/125 Pulmonary Medicine Head of Department: Prof. Dr. Sema Umut Phone: +902124143000/21814 Secretary: +902124143000/21686 E-mail: [email protected]

Semester: 9-10

Credit of Course: 4

ECTS Credit of Course: 4

Clerkship aims and learning outcomes English Clerkship content 3 weeks duration "Pulmonary Diseases probation" includes the theoretical lectures and clinical practice that are accompanied by faculty members Course aims The aim is transferring the information about the diseases related to respiratory system and diagnostic methods those medical students should aware for routine practical application. The aim is to understand the importance of emergency situations related to pulmonary diseases and to understand the importance of common diseases of the respiratory system in the community. Tha aim is the right differential diagnosis of diseases of the respiratory system. Learning 1- To be aware of the important point of taking history and to be able to take outcomes complete medical history. 2- To apply all methods of physical examination of respiratory system 3- To evaluate chest x-ray 4- To evaluate spirometry, and knowing the indications of other respiratory function tests (diffusing capacity, lung volumes, pulmonary pressures, reversibility, bronchial provocation testing, exercise testing). Able to take and to interpret the outcome of arterial blood gas. 5- To properly apply and interpret tuberculin skin test, 6-To be able to count indications, contraindications and complications of bronchoscopy 7- To be able to put the diagnosis and giving the first treatment of asthma attack,COPD attack, pulmonary embolism, pneumothorax, ARDS. 8-To be aware of the importance of epidemiology of tuberculosis disease; to be able to put the diagnosis, giving right treatment and know the side effects of treatment. 9- To be aware of the clinical and laboratory findings of lung cancer, pleural disease, occupational lung disease, interstitial lung disease, bronchiectasis, sleep- related breathing disorders, lung abscess and pulmonary hypertension. 10- To be aware of the importance of cigarettes for lung diseases and to be able to discuss smoking cessation methods. 11-To be able to count the indications for oxygen therapy. Teaching methods Giving lecture (slide presentations), interactive case presentations, practical and strategies application at the bedside, laboratory applications

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 102/125 Lectures No 1. The aims and objectives of Chest Diseases internship 2. General symptoms 3. Physical examination 4. Macro and microstructure of the lung 5. Chest radiology I 6. Chest radiology II 7. Lung function tests 8. Routine diagnostic procedures 9. Patogens of pulmonary tuberculosisesi 10. Clinic and laboratory of pulmonary tuberculosis 11. Pulmonary tuberculosis treatment 12. COPD I 13. COPD II 14. Pulmonary hypertension and cor Pulmonale 15. Respiratory failure and oxygen treatment 16. Lung cancer I 17. Lung canser II 18. İdiopathic pulmonary fibrosis 19. Sarcoidosis 20. Pulmonary emboli 21. Asthma I 22. Asthma II 23. Pneumonia I 24. Pneumonia II 25. Empyema-Abscess 26. Pulmonary Edema 27. Pleural diseases I 28. Pleural diseases II 29. Occupational Diseases 30. Smoking and lung 31. Bronchiectasis, and Cystic Fibrosis 32. Sleep related breathing disorders 33. Emergencies in pulmonary diseases

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 103/125 Cardiovascular Surgery Head of Department: Prof. Dr. Hasan Tüzün Phone: +902124143000/21083 Secretary: +902124143000/22025 E-mail: [email protected]

Semester: 9-10

Credit of Course: 3

ECTS Credit of Course: 3

Clerkship aims and learning outcomes English Clerkship content To learn surgical treatment of vascular and cardiac diseases. Course aims To teach surgical perspectives in cardiovascular patients. Learning To give the correct vision diagnose and to take proper surgical treatment by a 1st outcomes hospital doctor. Teaching methods Lectures, bed-side teaching case presentations,operating room, visits and and strategies observations

Lectures No 1. Acute Arterial Occlusions 2. Peripheral Vascular Injuries 3. Introduction to Cardıovascular Surgery 4. Acute Arterial Aneurysms 5. ASD and AV Canal Defects 6. T.O.S and Venospatic Diseases 7. Coarctation of Aorta and Anomalies of The Aortic Arch 8. Peripheral Occlusive Arterial Diseases 9. Aortic Dissection 10. Mitral Valve Diseases 11. Aortic Valve Diseases 12. Upper Extremity and Carotid Artery Diseases 13. PDA 14. Cyanotic Cardiac Malformations Other Than Fallot 15. VSD 16. Vasculitis, Buergers and A-V Malformations 17. Heart and Heart-Lung Transplantation 18. Tetralogy of Fallot 19. Pericardial Diseases 20. Chronic Venous Diseases and Deep Vein Trombosis 21. Surgical Therapy Ischemic Heart Disease

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 104/125 Case Discussions No 1. Constrictive pericarditis 2. Mitral valve stenosis 3. Aortic valve stenosis 4. Acute arterial embolia 5. Deep vein thrombosis and pulmonary embolia 6. Coronary arterial disease 7. Buerger disease 8. Carotid Artery Disease 9. Venous insufficiency 10. Abdominal aortic aneurysm 11. Tetralogy of Fallot 12. Chronic aorto iliac occlusions

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 105/125 Thoracic Surgery Head of Department: Prof. Dr. Akif Turna Phone: +902124143000/22486/139 Secretary: +902124143000/22484 E-mail: [email protected]

Semester: 9-10

Credit of Course: 1

ECTS Credit of Course: 1

Clerkship aims and learning outcomes English Clerkship content 1. Lung Tumors and Surgical Therapy 2. Mediastinal Cysts and Tumors 3. Cystic and Suppurative Diseases of the Lung 4. Tracheal Dıseases And TOS 5. Chest Wall Deformities and Tumors 6. Pleural Diseases and Tumors 7. Thoracic Traumas and Foreign Body Aspiration Course aims To teach and to define; 1. What we know about lung cancer , which patients are candidate for surgery, and steps of thoracic surgical intervention 2. Management of Mediastinal Cysts and Tumors and surgical treatment 3. Cystic and Suppurative Diseases of the Lung, to define which patients are candidate for surgery,and steps of thoracic surgical intervention 4. What we know about tracheal Dıseases and TOS, which patients are candidate for surgery, and steps of thoracic surgical intervention 5. Surgical treatment of Chest Wall Deformities and Tumors 6. Surgical treatment of Pleural Diseases and Tumors and patient selection criterias 7. Emergency interventions for Thoracic Traumas and Foreign Body Aspiration, supportive therapy and surgery Learning The students can define and numerate in order to acknowledge outcomes 1. The importance and , management of lung cancer and surgical treatment options, 2. Clinical and surgical characteristics of Mediastinal Cysts and Tumors, management and surgical treatment options 3. Importance of Cystic and Suppurative Diseases of the Lung, management of the patient , and surgical treatment options 4. Clinical Evaluation of Tracheal Diseases and TOS, management of Tracheal Diseases,TOS and surgical treatment options 5. Management of Chest Wall Deformities and Tumors, patient selection criteria 6. Approach to a patient with pleural effusion and surgical treatment of pleural tumors 7. Importance of Thoracic Traumas and Foreign Body Aspiration, emergency interventions and supportive therapy Teaching methods Lectures and interactive case presentations and strategies

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 106/125 Lectures No 1. Lung Tumors and Surgical Therapy 2. Mediastinal Cyst and Tumors 3. Cystic and Suppurative Diseases of the Lung 4. Tracheal Dıseases And TOS 5. Chest Wall Deformities and Tumors 6. Pleural Diseases and Tumors 7. Thoracic Traumas and Foreign Body Aspiration Case Discussions No 1. Pleural Diseases and Thoracic Emergency 2. Management of Lung Mass 3. Management of Mediastinal Mass 4. Management of Chest Wall Mass 5. Management of Tracheal Problem

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 107/125 Pediatric Surgery Head of Department: Prof. Dr. Haluk Emir Phone: +902124143000/22260 Secretary: +902124143000/21203 E-mail: [email protected]

Semester: 9-10

Credit of Course: 3

ECTS Credit of Course: 3

Clerkship aims and learning outcomes English Clerkship content 24 main courses in Pediatric Surgery Course aims To inform the students on the diagnosis and treatment of Pediatric Surgical Main Topics Learning To master the theoretical and practical skills of Pediatric Surgical Problems outcomes Teaching methods Theoretical and practical applications, clinical rounds and strategies Lectures No 1. Esophageal Atresia, GIS Atresia, Meconium ileus 2. Anorectal Malformations 3. Hirschsprung‟s Disease and Chronic constipation 4. Acute Abdomen, Appendicitis, Meckel‟s diverticulum, invaginasyon 5. Gastrointestinal bleeding (NEC,Polyps) 6. Infantile Hypertropic pyloric Stenosis and GER 7. Fluid electrolyte therapy 8. Surgical congenital Lung lesions, CDH 9. Abdominal Wall Defects and Thoracic deformities 10. Head-Neck Pathologies 11. Trauma, Child Abuse 12. Extrophy-Epispadias Complex 13. Penile anomalies, hypospadias, circumcission 14. Disorders of Sex Development 15. Urinary tract infections and VUR 16. Urinary Incontinence 17. Inguinal canal pathologies 18. Obstructive Uropathies 19. Urolithiasis 20. Pediatric age solid Tumors:(Noroblastom, Wilms, Rhabdomyosarcoma, Teratoma and gonadal tumors) 21. Portal Hypertension, Surgical Jaundice, Transplantasyon 22. Hepatoblastoma, Congenital Malformations pf the Spleen and Pancreas

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 108/125 Radiation Oncology Head of Department: Prof. Dr. İsmet Şahinler Phone: +902124143000/22495 Secretary: +902124143000/21289 E-mail: [email protected]

Semester: 9-10

Credit of Course: 1

ECTS Credit of Course: 1

Clerkship aims and learning outcomes English Clerkship content General concept of oncology and radiation oncology Course aims Students must gain general concept of oncology and radiation oncology Learning Students must understand role of radiotherapy in the management of cancer outcomes Teaching methods Classes,clinical and laboratory practices and strategies

Lectures No 1. The basic principles of radiation oncology 2. Clinical radiation oncology 3. Head and neck cancer 4. Central Nervous System Tumors 5. Gynecologic cancer 6. Pediatric tumors 7. Lung cancer 8. Urologic tumors 9. Breast cancer 10. Gastrointestinal tumors 11 Lymphomas 12. Skin tumors 13. Bone and soft tissue sarcomas

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 109/125 Case Discussions No 1. Laryngeal tumors 2. Tumors of the prostate 3. Oral cavity tumors 4. Breast cancer 5. Gastrointestinal system tumors 6. Lung cancer 7. Uterus tumors 8. Cervix tumors 9. Central Nervous System Tumors 10. Bladder tumors 11. Lymphomas 12. Pediatric tumors 13. Nasopharyngeal tumor 14. Oropharyngeal tumors 15. Tumors of the ovary 16. Tumors of the vulva 17. Tumors of the testis

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 110/125 Plastic and Reconstructive Surgery Head of Department: Prof. Dr. Yağmur Aydın Phone: +902124143000/21552 Secretary: +902124143000/21315 E-mail: [email protected]

Semester: 9-10

Credit of Course: 3

ECTS Credit of Course: 3

Clerkship aims and learning outcomes English Clerkship content General plastic surgery, skin cancer, burned treatment, microsurgery topics, head and neck cancer. Course aims Provide basic plastic, reconstructive and aesthetic surgery topics and techniques Learning At the end of Plastic Surgery internship the students should: outcomes 1) Describe treatment methods, 2) Describe basic subjects plastic surgery. Teaching methods Theoretical and practical expression and active participation. and strategies

Lectures No 1. Wound Healing 2. Hypertrophic Scar and Keloid 3. Flaps & Grafts 4. Burns 5. Complications of Burns 6. Autogenous Tissue Transplantation and Use of Alloplastic Implants in Plastic Surgery 7. Diabetic and Chronic Wounds 8. Lymphedema 9. Hemangiomas and Vascular Malformations 10. Pigmented benign Lesions of Skin 11. Basal Cell & Squamous Cell Carcinomas of Skin 12. Malignant Melanoma 13. Intraoral Cancers 14. Cancers of the Perioral Region 15. Face Embryology, Cleft Lip & Cleft Palate 16. Introduction to the Craniofacial Surgery Craniofacial Microsomia and Hypertelorism 17. Craniosynostoses and Craniofacial Clefts 18. Facial Injuries 19. Fractures of the Lower Face 20. Fractures of the Mid-Face 21. Fractures of the Upper Face 22. Basic Hand Anatomy and Principles of the Hand Surgery 23. Congenital Anomalies of the Hand 24. Tendon and Nerve Injuries of the Hand 25. Hand Replantation 26. Nerve Entrapment Syndromes, Dupuytren‟s disease 27. Breast Reconstruction after Mastectomy 28. Rhinoplasty

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 111/125 No 29. Face lifting 30. Blephoroplasty 31. Minimal invasive aesthetic procedure of the face 32. Breast reduction, mastopexy, breast augmentation 33. Abdominoplasty 34. Body countering and Liposuction 35. Postbariatric surgery

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 112/125 Nuclear Medicine Head of Department: Prof. Dr. Kerim Sönmezoğlu Phone: +902124143000/*22340 Secretary: +902124143000/21938 E-mail: [email protected]

Semester: 9-10

Credit of Course: 1

ECTS Credit of Course: 1

Clerkship aims and learning outcomes English Clerkship content The Diagnostic and therapeutic methods by using radioactive elements Course aims To provide students the ability in diagnosis and therapy of diseases by nuclear medicine methods Learning To make correct and appropriate indications for Nuclear Medicine procedures and outcomes to guide patients accordingly in their medical practice Teaching methods The lectures will be given theoretically supported by experimental and clinical and strategies examples

Case Discussions No 1. Hyperthyroidism 2. Hypothyroidism 3. Thyroid Cancer 4. Thyroid Nodule 5. Thyroiditis 6. Patient with Ischemic Heart Disease 7. Viability Assessment in Myocardium 8. Cardiomyopathy 9. Myocardial Infarct 10. Cardiac Pet 11. Metastatic Bone Disease 12. Primary Bone Tumor 13. Osteomyelitis and Prosthetic Infection 14. Metabolic Bone Disease 15. Patient With Pulmonary Embolus 16. Gastric Emptying and Reflux 17. Neonatal Hepatitis and Biliary Atresia 18. Obstructive Disease of Biliary System 19. Patient with Lymphoma 20. Lung Cancer 21. Colon Cancer 22. Frequent Urinary System Infections 23. Hydronephrosis 24. Hydrocephalia 25. Dementia 26. Meckel Diverticula 27. Neuroroblastoma 28. Renovascular Hypertension 29. Neuroendocrine Tumor 30. Watery Eye

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 113/125 Cardiology Head of Department: Prof. Dr. Hüsniye Yüksel Phone: +902124143000/21249 Secretary: +902124143000/21664 E-mail: [email protected]

Semester: 9-10

Credit of Course: 4

ECTS Credit of Course: 4

Clerkship aims and learning outcomes Clerkship content In cardiology clerkship, case discussions and analyses are led by the academic staff in the morning hours and then bed-site clinical practices are carried out under the supervisionof academicians. Lectures on main cardiology topics are given by the academic staff in the afternoon.

Course aims The aim of the clerkship of cardiology is to equip the students with the knowledge and skill of implementation of the methods for prevention from cardiovascular disease, train them to manage and diagnose the life threatening cardiac emergencies and teach how to follow up and treat the patients with known cardiovascular disease.

Learning 1. Can correctly diagnose valvular disease with the means of physical examination outcomes and laboratory examinations, knows medical management, surgical indications and perioperative anticoagulation management. 2. To point out the significance of this subject which is a common health problem in the community and should be acknowledged not only by cardiology specialists but also general practitioners. 3. To emphasize the importance of symptoms and physical examination in the diagnosis of heart failure. 4. To elucidate the necessity of support of the diagnosis with the objective findings. 5. To discuss the challenges in diagnosis and to teach the contemporary diagnostic methods 6. To reveal the importance of evidence based medicine. 7. To teach the contemporary management. 8. To emphasize the importance of history taking and physical examination in diagnosis of the infective endocarditis. 9. To discuss the challenges in diagnosis and criteria of diagnosis 10. To notify the importance od early diagnosis and management 11. To emphasize the importance of multidisciplinary approach in diagnosis of infective endocarditis. 12. To discuss the frequency of common cardiac tumors in the society, to teach how to make differential diagnosis. The topics to learn these objectives are; 13. Epidemiology (primary and metastatic cardiac tumors) 14. Benign and malignant tumors, types, sizes and localization of tumors, clinical characteristics, diagnostic methods and management. 15. Discuss the role of physical examination, symptoms and diagnostic methods in the diagnosis of cardiyomyopathies. 16. Defines the classification of cardiomyopathies. 17. Elaborates on the differential diagnosis and contemporary management

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 114/125 methods. 18. Acquire awareness on the importance of symptoms and clinical findings in aortic diseases. 19. Discuss the differential diagnosis and use of contemporary diagnostic tools. 20. Discuss the contemporary management of aortic diseases 21. Discuss how to prevent the complications of aortic diseases with the implementation of contemporary management 22. Defines the types of syncope predicting sudden cardiac deaths, sudden etiology of cardiac deaths below 30 years of age, causes of orthostatic syncope, prevention of sudden cardiac death 23. Learns the concept of systolic pressure gradient at the level of aorta in aortic stenosis (LV-Aorta). 24. Learns the concept diastolic pressure gradient at mitral valve in mitral stenosis (PCWP-LVEDP). 25. Defines pulmonary capillary wedge pressure; importance and its role in definition of pulmonary hypertension 26. Discuss contraindications and patients with high risk of death 27. Discuss contrast induced nephropathy; predisposing factors and prevention 28. Defines patients with high risk of death following the 30 days of NSTEMI 29. Defines acute management of patients with STEMI and medical management at discharge 30. Defines advantages and disadvantages of bare metal and drug eluting stents in patients undergoing PCI 31. Acknowledges antiplatelet management and its importance during and following PCI 32. Classifies types of pulmonary hypertension, defines etiologic and physiopathology factors of each type, acknowledges differential diagnosis, management and prognosis of pulmonary hypertension. Acquires awareness of the importance of early diagnosis. 33. Defines corpulmonale and acknowledge the diseases associated with corpulmonale. Knows the approach in diagnosis and management of the disease. 34. Can discuss the ECG findings of corpulmonale. 35. Acknowledges the physiologic cardiovascular changes and the associated physical findings in normal pregnancy. 36. Can recognize the symptom and findings in cardiac diseases. 37. Defines the high risk cardiovascular states in pregnancy and knows how to guide the patient. 38. Defines the symptoms and findings of physical of peripartum cardiomyopathy 39. Recognizes and knows the clinical significance of ventricular premature beats, escape beat, ventricular tachycardia, ventricular fibrillation, Torsade des pointes, idioventricular rhythm, accelerated idioventricular rhythm, ventricular asystole, 40. Defines the characteristics of stable angina pectoris and discuss the significance. 41. Defines the features of cardiac and non-cardiac chest pain and discuss the differential diagnosis. 42. Defines the diagnostic methods used in investigation of myocardial ischemia. 43. Acknowledges the drugs prescribed in medical management of stable angina pectoris. 44. Recognize pulmonary emboli and discuss its significance. 45. Acknowledges the etiology of pulmonary emboli. 46. Can list the diagnostic tools. 47. Can list the findings of acute right ventricular dysfunction. 48. Defines the indications of thrombolytic and anticoagulant management. 49. What are cardiovascular risk factors 50. The impact of smoking on heart 51. How to perform physical exercise? 52. How to measure body mass index and waist circumference and their normal limits. 53. How to diagnose diabetes? 54. Correct measurement of blood pressure, normal limits and management.

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 115/125 55. What's dyslipidemja, what are the normal limits and how to manage dyslipídemia? 56. What is metabolic syndrome and what are the criteria of metabolic syndrome? 57. What are the non-invasive diagnostic methods? 58. Which diagnoses are made by ECG? 59. What are the indications, contraindications and criteria for termination of the exercise stress EGC test? 60. What is Holter examination and what are the indications for the use of Holter monitoring? 61. Who deserves ambulatory blood pressure monitoring and what are the normal limits? 62. What are the superiorities of echocardiography examination? 63. How and why a myocardial perfusion scintigraphy is performed? 64. Defines the pathologic cardiac findings on x-ray examination. 65. Interprets the ECG findings of supraventricular tachycardias, classifies and manages supraventricular tachycardias in acute setting. 66. Discuss the complications and management principles of atrial fibrillation.. 67. Interprets the ECG of conduction disorders and correctly diagnoses different types of conduction abnormalities 68. Discuss the basic approach to management of patients undergoing non-cardiac surgery. 69. Defines the concept of evidence based medicine. 70. Defines the classification of level of evidence, defines meta-analysis and guidelines. 71. Discuss the evidence based management of cardiovascular disease. 72. Defines the symptoms and ECG findings of acute coronary syndromes, acknowledges that the decisive management can only be done in the hospital setting, learns what to do during the referral and transport to the hospital.

Teaching methodsThe first hours of the morning, accompanied by faculty members with the ability to and strategies obtain recognition in cardiology applications and how to use them in discussion and case analysis in bulk for faculty members, accompanied by a patient applications, as described in the corporate information to the afternoon lessons.

Lectures No 1. Heart valve disease l, II, III 2. Acute Coronary Syndrome l, II, III 3. Cardiac tumors 4. Physiopathology 5. Cardiomyopathies 6. Aortic diseases 7. Sybcop and sudden death 8. Heart catheterization and basic indications 9. Coronary angiography and indications 10. Clinical indications and contraindications of percutaneous coronary interventions 11. PCI in acute coronary syndromes: primary PCI in STEMI and urgent PCI in NSTEMI 12. ICD significance and indications 13. CRT mechanism and indications 14. Percutaneous mitral balloon valvuloplasty- indications and contraindications 15. Heart failure 16. Infective endocarditis 17. Clinical approach to supraventricular tachcardias 18. Clinical approach to conduction disorders. 19. Evaluation of cardiac patients undergoing non- cardiac surgery 20. Pulmonary hypertension and corpulmonale

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 116/125 Case Discussions No 1. Basic ECG 2. Pathological ECG samples 3. Plain chest radiogram 4. Cardiac symptoms 5. Cardiac physical examination

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 117/125 Infectious Diseases Head of Department: Prof. Dr. Recep Öztürk Phone: +902124143000/21957 Secretary: +902124143000/21688 E-mail: [email protected]

Semester: 9-10

Credit of Course: 4

ECTS Credit of Course: 4

Clerkship aims and learning outcomes English Clerkship content Course programme includes lectures and training in order to provide general approaches about epidemiology, diagnosis, treatment, prevention and referral practices of the most common infectious diseases in our country and worldwide. Course aims Trainees should gain familiarity about the etiopathogenesis, clinical and diagnostic features, prevention measures of the most common community acquired infections; should gain skills for diagnosis, differantial diagnosis, treatment and follow up of outpatients; should know the basic principles the initial response of emergent cases and referral practices. Learning By the end of Infectious Diseases clerkship, students should be able to: outcomes 1. Describe the most important infectious diseases for the region and the country 2. Describe the symptoms, clinical and laboratory findings of the most common community acquired infectious diseases and the infectious and non-infectious diseases in the differential diagnosis and apply the required medical interventions on the primary-care level. 3. Be aware of the infections in immunocompromised hosts, infections related with foreign devices and healthcare related infections. 4. Rationally use and interpret the diagnostic tools in community acquired infectious diseases 5. Treat the most important community acquired infections for region and country, recognize the complicated cases and refer to the reference centers. 6. Recognize and report the diseases those are obligatory to be reported on the primary healhcare level. 7. Recognize emerging diseases and outbreaks in the community, get in contact and establish relationships with relevant sides and subjects, carry out preliminary investigations. List the principles of rational use of 8. List the principles of rational antimicrobial use , mechanisms of activity of antimicrobial agents, spectra, side effects and drug interactions 9. Be aware of antimicrobial resistance rates and mechanisms in the most common community acquired infections, interpret the antimicrobial susceptibility test results. 10. Know the principles of adult immunization and chemoprophylaxis, implement and follow up.

Teaching methods Lectures, case discussions, clinical and laboratory practices. and strategies

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 118/125 Lectures No 1. Differential diagnosis in Infectious Diseases 2. Diagnosis, differential diagnosis and treatment approaches in Infectious diseases emergencies 3. Differential diagnosis in acute respiratory diseases and influenza 4. Diagnosis, differential diagnosis and treatment in CVS Infections I 5. Diagnosis, differential diagnosis and treatment in CVS Infections II 6. Diagnosis, differential diagnosis and treatment in intraabdominal infections I 7. Rational laboratory use in Infectious Diseases 8. Antifungal and antiviral drugs 9. Infectious diarrhea 10. Bone and joint infections 11. HIV infection 12. Infections related to health services 13. Infections of immunocompromised hosts 14. Immunization in adults 15. Travel medicine 16. Important protozoal infections 17. Fever of unknown origin 18. Extrapulmonary tuberculosis 19. Mononucleosis syndrome (EBV, CMV) 20. Antibacterial drugs I 21. Antibacterial drugs II 22. Zoonotic infections I (leptospirosis, brucellosis) 23. Zoonotic infections II (ricketsiosis, Bartonella diseaseı, Lyme disease) 24. Lower respiratory tract infections 25. Diabetic foot infection 26. Urinary system infections 27. Skin and soft tissue infections 28. Treatment of intestinal paracytosis 29. Rational antibiotic use in clinical practice 30. Sepsis syndrome 31. Sexually transmitted diseases 32. Acute viral hepatitis 33. Chroniz viral hepatitis 34. New and recently importantly emerging infections

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 119/125 Forensic Medicine Head of Department: Prof. Dr. Gürsel Çetin Phone: +902124143000/21782 Secretary: +902124143000/21786 E-mail: gcetin@ istanbul.edu.tr

Semester: 9-10

Credit of Course: 4

ECTS Credit of Course: 4

Clerkship aims and learning outcomes English Clerkship content Turkish Penal Code and Wounds, Legal responsibilities of physicians, Violation of human rights, Basics of death, Evaluation of forensic cases and reporting, Firearm and explosive wounding, Wounds, Asphyxia, Forensic Psychiatry and drug addiction, Sexual assault, Child abuse, Pregnancy and birth, Forensic Toxicology Course aims Acquitance of Knowledge and practice by physicians in the framework of core content for forensic medicine. Learning At the end of the practice, students, besides knowdlegdes of Forensic Medicine, outcomes should have achieved basic knowledge of death, forensic autopsy, asphyctic deatahs, knowledge sufficient fort he diagnosis of wounds, legal respyonsibilities of the physician, physical hazards, sexual assaults, cihid abuse ant intra-family violence, graviditiy, pregnanciy and abortus amd related aspects, forensic toxicology, approach to the legal case in the level of material obtaining and further emergency activities, issuing of legal reports, natural deaths, extenral examination of the deceased, Traumatisation yin the framework of the Turkish Penal Code Teaching methods Lectures and practices and strategies Lectures No 1. Introduction into Forensic Medicine 2. Turkish Penal Code and Wounds 3. Legal responsibilities of physicians 4. Violation of human rights 5. Basics of death 6. Filling up death form 7. Obtaining of a burial permit 8. Natural death 9. Evaluation of forensic cases and reporting 10. Firearm and explosive wounding 11. Wounds 12. Asphyxia 13. Forensic Psychiatry and drug addiction 14. Sexual assault 15. Child abuse 16. Pediatric death 17. Pregnancy and birth 18. Forensic Toxicology 19. Physical and chemical hazards 20. Forensic Identification 21. Medicolegal autopsy 22. Drowning 23. Medicolegal reporting

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 120/125 Dermatology Head of Department: Prof. Dr. Yalçın Tüzün Phone: +902124143000/21500 Secretary: +902124143000/21546 E-mail: [email protected]

Semester: 9-10

Credit of Course: 4

ECTS Credit of Course: 4

Clerkship aims and learning outcomes English Clerkship content Dermatology internship gives information and skills about the etiology and classification of leprosy, clinical symptoms and complication of the diseases. Course aims Teaching clinical types, clinical symptoms and clinical complications and treatments. Learning At the end of dermatology clerkship the students should describe clinical types, outcomes clinical symptoms and clinical complications and treatments. Teaching methods Lectures, clinical practices and strategies

Lectures No 1. Dermatologic Diagnosis 2. Structure and Features of Skin 3. Differential Diagnosis of Diseses Localized Hand and Foot 4. Acne 5. Topical Therapy 6. Viral Skin Diseases 7. Psoriasis 8. Other Papulosquamous Diseases 9. Autoimmune Bullous Disorders 10. Syphilis 11. Genital Discharge 12. Genital HPV Infections 13. Genital Ulcer Diseases 14. Scabies, Pediculosis 15. Leishmaniasis Cutis 16. Recurrent Aphthous Stomatitis 17. Behçet‟s Disease 18. Atopic Dermatitis 19. Contact Dermatitis 20. Etiology of Skin Cancers 21. Malign Melanoma 22. Non-melanoma Skin Cancer 23. Precancerous Lesions 24. Superficial Mycoses 25. Streptococcal Infections 26. Staphylococcal Infections 27. Urticaria 28. Angioedema

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 121/125

Case Discussions No 1. Viral skin diseases 2. Psoriasis and psoriasiform diseses 3. Autoimmune bullous disorders 4. Sexually transmitted diseses 5. Mycobacterial skin infection 6. Parasitic infestation of the skin 7. Differential diagnosis of diseses localized hand and foot 8. Precancerous lesions 9. Skin cancer 10. Eczematous dermatitis 11. Superficial mycoses 12. Bacterial infections 13. Urticaria

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 122/125 Public Health Head of Department: Prof. Dr. Mehmet Sarper Erdoğan Phone: +902124143000/22902 Secretary: +902124143000/21566 E-mail: [email protected]

Semester: 9-10

Credit of Course: 4

ECTS Credit of Course: 4

Clerkship aims and learning outcomes English Clerkship content Try to teach the students with the consept of public health thinking and approach to the problems and ensure to find solution with this consept. Course aims Try to teach the students with the consept of public health thinking and approach to the problems and ensure to find solution with this consept. Learning Possession of information of the students on infectious diseases of global public outcomes struggle, the mother and child programs, chronic diseases and related public wearing protective programs, occupational safety and worker health, environmental health, health care organizations Teaching methods Interactive lectures and strategies

Lectures No 1. Control of communicable diseases: bacterial vaccines 2. Control of communicable diseases: viral vaccines 3. Control of communicable diseases: parasitic vaccines 4. Vaccines of gastrointestinal system 5. Vaccines for adults 6. Prevention of communicable diseases 7. Prevention of zoonotic diseases I 8. Prevention of zoonotic diseases II 9. Development of medical services in Turkey and basic health services 10. Health management 11. Health legislation 12. Health economics 13. Epidemiology of chronic diseases 14. Work injuries 15. Occupational health and safety 16. Occupational hygiene 17. Inequalities in health sector 18. Principles preventive medicine and actual problems 19. Organization of maternal and infant health services in Turkey 20. Causes of maternal death from a Public Health perspective 21. Causes of infant death from a Public Health perspective 22. Food additives and their contaminants 23. Nutrition of public 24. Methodology in medical researchs (Introduction and descriptive studies) 25. Methodology in medical researchs (Analytic studies) 26. Methodology in medical researchs (Trials) 27. Methodology in medical researchs (Methodological studies)

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 123/125 No 28. Occupational diseases caused by physical effects 29. Occupational diseases caused by chemical and biological effects 30. Informatics implementations in health sector 31. Health management in secondary care 32. Health legislation in secondary care 33. Effects of electromagnetism on human health 34. Health effects of ionized radiation and preventive measures 35. Evaluation of environmental effects 36. Climatic changes and possible effects on human health 37. Investigation of an outbreak with examples 38. Air pollution (physical, biological, chemical) 39. Heavy metalls and effects on health 40. Relation between water and health 41. Important environmental pollutants (Radon, PCBS, Dioxin, Furan, Radon)

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 124/125 6th Year Internships  Emergency Medicine (8 weeks)  Pediatrics (8 weeks)  Internal Medicine (8 weeks)  Public Medicine (6 weeks)  General Surgery (6 weeks)  Pschiatry (3 weeks)  Neurology (3 weeks)  Gynecology and Obstetrics (4 weeks),  Dermatology ( 2 weeks)  Elective ( 4 weeks) Total: 52 weeks.

Istanbul University, Cerrahpaşa Medical Faculty 2015-2016 Academic Year Synopsis of Curricula; Version 14-Jul-15; Page 125/125