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Program and Abstracts PROGRAM AND ABSTRACTS CONFERENCE ORGANIZED BY: PROGRAM AND ABSTRACTS The Eighth ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine International Society for Applied Biological Sciences (ISABS) June 24—28, 2013, Split, Croatia ORGANIZED UNDER THE AUSPICES OF: Croatian Academy of Sciences and Arts GENERAL SPONSOR: OFFICIAL JOURNAL: Croatian Medical Journal CO-ORGANIZED BY: PROGRAM AND ABSTRACTS Publisher: THE EIGHTH ISABS CONFERENCE International Society for Applied Biological Sciences (ISABS) IN FORENSIC, ANTHROPOLOGIC AND MEDICAL GENETICS Editors: AND MAYO CLINIC LECTURES IN TRANSLATIONAL MEDICINE Stanimir Vuk-PavloviÊ, Dragan Primorac, Moses Schanfield Assistant Editors: Inga MarijanoviÊ, Bojana Kriænik Prepress: Forma ultima, Zagreb Printed by: Graphic Art, Zagreb, 2013 Circulation: 700 copies JUNE 24—28, 2013 ISBN 978-953-57695-0-7 Le Meridien Lav Hotel, Split, CROATIA A CIP catalogue record for this book is available in the Online Catalogue of the National and University Library in Zagreb as 845789 www.isabs.hr [email protected] Copyright ISABS 2013 Video and/or audio-taping of any session is not permitted without prior approval from speakers and Scientific Committee of the 8th ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine Conference floor layout Contents TABLE OF CONTENTS Welcome note .................................................................................................. 7 Foreword .......................................................................................................... 8 Conference organizer ....................................................................................... 9 ISABS committees ........................................................................................... 12 GrljevaËka 2A, Podstrana Young investigator awards ............................................................................. 15 21312 Split Scientific program information ....................................................................... 16 General information ....................................................................................... 18 Invited speakers .............................................................................................. 19 Scientific program .......................................................................................... 22 Keynote addresses .......................................................................................... 29 Abstracts of invited lectures ............................................................................ 35 Workshops ................................................................................................... 101 Young investigator award presentations ....................................................... 135 Submission selected for podium presentations ............................................. 141 Abstracts of poster presentations ................................................................. 153 About invited speakers ................................................................................. 339 Sponsor information ..................................................................................... 349 Author index ................................................................................................ 359 Keyword index ............................................................................................. 369 4 8th ISABS Conference in Forensic, Anthropologic and Medical Genetics 8th ISABS Conference in Forensic, Anthropologic and Medical Genetics 5 and Mayo Clinic Lectures in Translational Medicine and Mayo Clinic Lectures in Translational Medicine June 24—28, 2013, Split, Croatia June 24—28, 2013, Split, Croatia Welcome note WELCOME TO THE EIGHTH ISABS CONFERENCE IN FORENSIC, ANTHROPOLOGIC AND MEDICAL GENETICS AND MAYO CLINIC LECTURES IN TRANSLATIONAL MEDICINE! The conference is next in the series of biennial events organized by the Interna- tional Society for Applied Biological Sciences, a society dedicated to promotion of applied molecular biology (www.isabs.hr). This conference is organized with par- ticipation of Mayo Clinic, Penn State University, University of New Haven, George Washington University, Universities of Split, Osijek and Rijeka, Ruer BoπkoviÊ In- stitute, Institute of Anthropology, Genos Ltd, Croatian Society of Human Genetics, Croatian Forensic Association, Children’s Hospital Srebrnjak, St. Catherine Hospi- tal, Croatian Society of Human Genetics, Croatian Academy of Technical Sciences, Croatian Academy of Legal Sciences and the City of Split. As in the past, this con- ference is organized under the auspices of the Croatian Academy of Sciences and Arts. Croatian Medical Journal, the official journal of ISABS, will publish the con- ference papers in its ninth special ISABS edition. Since the initiation of the series in 1997, we have strived both to focus and broad- en the scope of the conferences. The focus has been on the application of cutting- edge analytical methodology in forensic science. Since 2007 we have broadened the area of interest by the introduction of molecular anthropology that, in large part, shares the methodology with forensic genetics. In 2009, we introduced selected topics from individualized medicine, another applied discipline based on the advances in mapping of the human genome. In 2011, the conference dis- cussed the new molecular methods in early cancer diagnosis, new approaches to AIDS treatment, non-invasive prenatal diagnostics, gene and cell therapy, pheno- type prediction from genetic information, identification of victims of mass disas- ters, plant and animal DNA analysis, cold-case forensics, and selected topics in molecular anthropology. This year we are pleased to introduce the up-to-date advances in genetics applied to the crossing of forensic science, anthropology and translational medicine. More than 500 participants and 80 lecturers including Nobel Laureates Aaron Ciechan- over, Robert Huber and Ada Yonath will participate in the conference. Principal sponsors of the conference are Pliva, Inc., Belupo, Inc. and the Seventh Framework Program of the European Union. As before, the conference is structured to allow close interaction of the interna- tional faculty and attendees. Together with formal presentations, there will be meet-the-professor sessions and other social occasions that are meant to enhance opportunities for scientific intercourse, but also to introduce the participants to the city of Split, the ancient maritime capital of Croatia and a vibrant modern Medi- terranean city. Enjoy! Moses Schanfield, Dragan Primorac, Stanimir Vuk-PavloviÊ Program/Conference Directors 8th ISABS Conference in Forensic, Anthropologic and Medical Genetics 7 and Mayo Clinic Lectures in Translational Medicine June 24—28, 2013, Split, Croatia Foreword ISABS Committees ISABS CONFERENCES JOIN FORCES 8TH ISABS CONFERENCE, WITH THE FP7-INTEGRA-LIFE PROJECT SPLIT, CROATIA, JUNE 24-28, 2013 From the very beginning in 1997, ISABS Conferences have been the flagship of • Organizer Croatian science, demonstrating that events of global importance can have their International Society for Applied Biological Sciences home in Croatia. Since the time of Ancient Rome, for nearly 2000 years, Croatia URL: http://www.isabs.hr was on the forefront of science and education in Europe. However, after the end of World War I, the Treaty of Versailles exiled Croatia to the Balkans, with devas- The conference is organized under the auspices of the Croatian Academy of tating consequences to its science and culture. After 95 years of exile, on July 1st, Science and Arts. 2013, only three days after the conclusion of the 8th ISABS Conference, Croatia will “return home” as the 28th member state of the European Union. • Program/Conference Directors Research and innovation are strategic objectives of the European Union, and the Moses Schanfield (George Washington University, Washington, DC, USA) Framework Programme (Horizon 2020 in the future) is its main tool for their pro- Dragan Primorac (University of Split and University of Osijek, Croatia; Penn State motion. Among the programmes of the FP7 are the highly competitive Research University and University of New Haven, USA) Potential (REGPOT) projects aimed at supporting centres of excellence in the EU Stanimir Vuk-PavloviÊ (College of Medicine, Mayo Clinic, Rochester, MN, USA) Convergence and Outermost regions. Integra-Life is one such Research Potential project whereby the European Commission will invest over 3,2 million Euros in the • Program Advisory Committee network of five research groups at the University of Zagreb. Frederick Bieber (Harvard Medical School, Boston, MA, USA) The main objective of Integra-Life project is to functionally integrate and reinforce Davor DerenËinoviÊ (University of Zagreb, Zagreb, Croatia) most promising research groups in molecular life sciences at the Faculty of Science Gordan Lauc (Genos, Ltd, DNA Laboratory, Zagreb, Croatia) and Faculty of Pharmacy and Biochemistry, University of Zagreb. All participating Damir MarjanoviÊ (IGEB, Sarajevo, Bosnia and Herzegovina) research groups have already demonstrated excellence in research and success in Damir Primorac (University of Split, Split, Croatia) raising international research funds. Integra-Life will support these groups through Pavao Rudan (University of Zagreb, Zagreb, Croatia) coherent acquiring
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