DOCSLIB.ORG

2014 ADA Posters 389-1318.Indd

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
2014 ADA Posters 389-1318.Indd COMPLICATIONS—HYPOGLYCEMIA COMPLICATIONS—HYPOGLYCEMIA & 390-P The Novel Glucagon Analogue ZP-GA-1 has Superior Physico- Guided Audio Tour: Predictors, Morbidity, and Mortality (Posters: 389-P to chemical Properties while Maintaining the Pharmacokinetic and 395-P), see page 17. Pharmacodynamic Profi le of Native Glucagon & 389-P DITTE RIBER, ANDERS VALEUR, METTE SVENDGAARD, FRANCESCA MACCHI, Benefi t-Risk Relationship between A1C and Hypoglycemia for LISE GIEHM, KELD FOSGERAU, PIA NOERREGAARD, Copenhagen, Denmark Glucagon is used in diabetic patients for treatment of severe episodes of Addition of Exenatide BID to Insulin Glargine in Patients with T2DM POSTERS JARET MALLOY, MING ZHOU, JENNY HAN, San Diego, CA, Hopewell, NJ hypoglycemia. Pharmaceutically, however, native glucagon possesses poor Complications Exenatide BID (ExBID) improves postprandial glucose and A1C with low physicochemical properties, making convenient dosing in a ready-to-use Acute and Chronic hypoglycemia (hypo) risk. Two 30-wk studies evaluated insulin glargine (IG; rescue pen or the development of an artifi cial pancreas diffi cult. Accordingly titrated per algorithm based on fasting glucose [goal <100 mg/dL]) + ExBID. In the development of novel glucagon analogues such as ZP-GA-1 is pursued. Study 1 (N=627), ExBID or insulin lispro (IL) was added to IG + metformin. In Study The solubility of ZP-GA-1 at physiological pH was shown to be >25 mg/mL 2 (N=259), ExBID or placebo was added to IG ± metformin and/or pioglitazone. and thus highly superior to that of native glucagon ~0.2 mg/mL. In addition, IL was titrated based on pre-meal glucose (goal =100 mg/dL with no hypo). We the stability data suggests that ZP-GA-1 is suitable for long term storage as quantifi ed the benefi t-risk relationship between A1C lowering and hypo risk a liquid formulation. The pharmacokinetic (PK) and pharmacodynamic (PD) versus comparators using Poisson regression models to evaluate hypo exposure- properties of ZP-GA-1 and native human glucagon were investigated in dogs. adjusted event rates (EAER) adjusted for the lowest A1C observed over 30 wks. In Animals were administered either subcutaneously (SC, 20 and 120 nmol/ both studies, IG + ExBID signifi cantly reduced A1C and weight. Study 1: With the kg) or intravenously (IV, 75 nmol/kg). Our data demonstrated overall similar same A1C achieved, hypo EAER was 58% less with IG + ExBID vs. IG + IL (risk ratio PK profi les as well as blood glucose (BG) profi les of ZP-GA-1 and glucagon. [RR] 0.42; p<.0001; Figure 1A). IG + ExBID reduced daytime (RR 0.19; p<.0001) and Further, the SC effect of ZP-GA-1 on BG in a rat model of hypoglycemia nocturnal hypo EAER (0.86; p=.076) vs. IG + IL. Overall, being female, lower BMI was investigated (Figure). Both ZP-GA-1 and glucagon restored BG to or longer diabetes duration resulted in signifi cantly higher hypo EAER. Study 2: baseline levels or above in a dose-dependent manner during insulin-induced hypo EAER was slightly lower for IG + ExBID than IG + placebo (RR=0.75; p=.107; hypoglycemia. In conclusion, ZP-GA-1 displays improved physicochemical Figure 1B). IG + ExBID signifi cantly reduced A1C and weight, and the modeled properties while maintaining similar PK and PD profi les compared to native A1C and hypo ben efi t-risk relationship further supported use of ExBID with IG glucagon. for patients with T2DM not at goal with titrated IG. & 391-P Naltrexone for Treatment of Hypoglycemia Unawareness in Type 1 Diabetes: A Randomized Clinical Trial AMIR MOHEET, SILVIA MANGIA, ANJALI KUMAR, NOLA TESFAYE, LYNN E. EBERLY, YUN BAI, ELIZABETH R. SEAQUIST, Minneapolis, MN Hypoglycemia unawareness (HU) is a limiting factor in the treatment of type 1 diabetes (T1D) and is a challenging problem to reverse. Previous studies have suggested that the opioid receptor antagonist naltrexone might be of benefi t in treatment of HU. The objective of this study was to test the hypothesis that naltrexone therapy in subjects with T1D and HU will improve counterregulatory (CR) hormone response, recognition of hypoglycemia (HG) symptoms and increase brain activation during HG in regions involved in the regulation of CR response to HG as measured by cerebral blood fl ow (CBF) using fMRI. We performed a pilot randomized double blind trial of 4 weeks of naltrexone 50 mg bid (n=11) or placebo (n=12) given orally in subjects with T1D and HU. Outcome measures included HG symptom scores, CR hormone levels and CBF measurement obtained during experimental HG in all subjects before and after 4 weeks of intervention. Subjects were defi ned as having HU based on Cox questionnaire. Baseline subject characteristics were similar between the naltrexone (A1C 7.0 ±0.6, Cox score 5.3±0.9) and placebo (A1C 6.5±0.7, Cox score 5.8±0.9) arms. After 4 weeks of therapy with naltrexone or placebo, no signifi cant differences were seen in any outcomes of interest within each group or between the treatment and placebo arms. At the end of study HG symptom scores (10±7 vs. 14±12, P=0.47) and CR hormone response including epinephrine (116±154 vs. 97±99 pg/ml, P=0.75), glucagon (65±40 vs. 47±12 pg/ml, P=0.25) and cortisol (19±7 vs. 20±8 mg/dl, P=0.35) were similar between the 2 groups. No differences were also seen in the brain activation pattern in response to HG between the 2 groups. In this small pilot study, treatment with naltrexone did not improve recognition of HG symptoms or CR hormone response during experimental HG in subjects with T1D and HU. Future studies with larger sample sizes and different dosing regimens will be necessary to fully evaluate the effi cacy of naltrexone as a treatment of HU. Supported By: ADA (7-07-DCS-02) Supported By: Bristol-Myers Squibb/AstraZeneca ADA-Funded Research & Guided Audio Tour poster For author disclosure information, see page A743. A103 COMPLICATIONS—HYPOGLYCEMIA & 392-P & 394-P Recent vs. Remote History of Severe Hypoglycemia (SH) as a Predictors of Hypoglycemia in Insulin-Treated Type 1 (T1) and Type Predictor of Mortality in Type 1 Diabetes (T1D) 2 (T2) Diabetes Patients: Analysis of Self-Reported Hypoglycemic GEORGIA PAMBIANCO, TINA COSTACOU, TREVOR J. ORCHARD, Pittsburgh, PA Events in 10 European Countries A history of SH has been associated with increased mortality in type 2 DOMINGO OROZCO-BELTRAN, PEDRO MEZQUITA-RAYA, WERNER KERN, BERN- diabetes. While in T1D up to 10% of deaths can be attributable to acute HARD KULZER, JORMA LAHTELA, ULRIK PEDERSEN-BJERGAARD, RAIMUND hypoglycemia, the role of a history of SH is unclear. We thus examined WEITGASSER, PETRONELLA GEELHOED-DUIJVESTIJN, CHANTAL MATHIEU, POSTERS Complications data from the ongoing Epidemiology of Diabetes Complications study of HENRIK HOLM JENSEN, ANTONIO RAMIREZ DE ARELLANO, MARIE MARKERT Acute and Chronic childhood onset T1D (mean age 28 and duration 19 years, n=658 at baseline JENSEN, San Juan de Alicante, Spain, Almería, Spain, Ulm, Germany, Bad (1986-88)) to determine if a self reported history of SH in the prior 2 years, Mergentheim, Germany, Tampere, Finland, Hillerød, Denmark, Salzburg, Austria, The is associated with total (n=76), CAD (no renal, n=27), renal (no CAD, n=14) or Hague, Netherlands, Leuven, Belgium, Holte, Denmark, Madrid, Spain, Copenhagen, CAD+renal (n=19) mortality, in 443 participants attending the 1990-92 exam Denmark when these questions were fi rst asked. SH was defi ned as unconsciousness, Unpredictability of hypoglycemia is an ever-present threat of insulin requiring assistance and/or having a low blood sugar (<50 mg/dl) without therapy and measures to prevent its incidence depend on knowledge of recognition. Death was classifi ed according to Diabetes Epidemiology predictors. The identifi cation of clinical and socio-demographic factors as Research International (DERI protocol) by a physician committee. Baseline markers of hypoglycaemia may improve diabetes management. (1990-1992) and most recent history of SH analyses were performed. The “Hypoglycemia in Insulin Treated diabetes” (HIT) Study included 5483 Separate multivariable Cox models were determined for each outcome based T1 and insulin-treated T2 patients in 10 European countries who reported on univariate signifi cance of previously established predictors. Baseline or rates of non severe hypoglycaemic events (NSHE) and related matters via 4 recent history of SH was forced into each model. The median time from online questionnaires. last follow up to death was 1.5 years. SH 2 years before baseline was not Risk markers were identifi ed in regression models. Weighting ensured independently related to total, CAD, renal, or CAD+renal mortality. SH in sample size and demographic features were similar in the 10 countries. the prior 2 years at most recent exam was not related to CAD or CAD+renal Markers of high frequency of NSHE for T1 patients were: female gender, mortality but was independently related to total mortality (HR=1.79, 1.1-2.9); longer duration of insulin treatment, >1 daily injections, Body Mass Index other predictors were diabetes duration, estimated glomerular fi ltration rate and perceived poor advice on hypoglycemia from GP (Table). Markers for T2 (eGFR), HbA1c, hypertension, smoking, albumin excretion rate (AER), and patients were the same, except for BMI. No statistical signifi cant association nonHDLc. A univariate association with renal mortality (HR=3.84, 1.3-10.9 was found with living status, primary education and work for pay. was weakened (HR=2.57, .89-7.4, p=0.08) with the addition of eGFR and AER. Gender, insulin duration and daily injections were found to be strong We conclude that SH in the last 1-4 years doesn’t increase CAD mortality predictors of NSHE in T1 and T2 diabetes.
Load more

Recommended publications
  • Final Program 6-21-05.Indd
    Final Program HCI International 11th International Conference on Human-Computer Interaction 2005jointly with Symposium on Human Interface (Japan) 2005 6th International Conference on Engineering Psychology & Cognitive Ergonomics 3rd International Conference on Universal Access in Human-Computer Interaction 1st International Conference on Virtual Reality 1st International Conference on Usability and Internationalization 1st International Conference on Augmented Cognition 1st International Conference on Online Communities and Social Computing July 22–27, 2005 Caesars Palace • Las Vegas, Nevada USA Under the auspices of 9 distinguished international boards of 201 members from 31 countries Full Day TutorialsHalf Day 1 Multimodal Interaction Design and Virtual Environments 5 Introduction to Usability Testing Leah Reeves, Kay M. Stanney, Kelly Hale, and Satha Samman, James R. Lewis, IBM University of Central Florida Milan Pisa 6 Speech-Enabled Web Applications 2 HCI Innovations in Korea James Larson, Intel Corporation Yong Gu Ji, Soongsil University; Wan C. Yoon, KAIST; Sung H. Han, Messina POSTECH; Myung Hwan Yun, Seoul National University; Jiyoung Kwahk, Samsung Electronics Co., Ltd.; Changsu Kim, Samsung Advanced Institute of Technology; Sookyung, Cho, SK Telecom noon Morning,am–12 8:30 Verona 3 An Overview of Human Information Processing for 7 Advanced Topics in Usability Testing 8:30 am–5 pm am–5 8:30 Human-Computer Interaction James R. Lewis, IBM Robert W. Proctor, Purdue University; Kim-Phuong Vu, California State Milan University 8 Card-Sorting Method for Cluster Analysis of Information Friday, July 22, 2005 22, July Friday, Palermo Architecture Design 4 Augmented Cognition Jianming Dong, eBay; Carol Righi, Righi Interface Engineering, Inc. Randy Pausch, Carnegie Mellon University; Dennis Proffitt, University Messina of Virginia Afternoon,pm 1:30–5 Trevi 9 A Practical Approach to Interactive System Design 14 Expediting the Usability Testing Process Michael E.
    [Show full text]
  • The Last Samurai: the Life and Battles of Saigo Takamori
    THE LAST SAMURAI The Life and Battles of Saigo- Takamori MARK RAVINA John Wiley & Sons, Inc. THE LAST SAMURAI THE LAST SAMURAI The Life and Battles of Saigo- Takamori MARK RAVINA John Wiley & Sons, Inc. This book is printed on acid-free paper. Copyright © 2004 by Mark Ravina.All rights reserved Published by John Wiley & Sons, Inc., Hoboken, New Jersey Published simultaneously in Canada Design and production by Navta Associates, Inc. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning, or otherwise, except as per- mitted under Section 107 or 108 of the 1976 United States Copyright Act, without either the prior written permission of the Publisher, or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923, (978) 750-8400, fax (978) 750-4470, or on the web at www.copyright.com. Requests to the Publisher for permission should be addressed to the Permissions Department, John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, (201) 748-6011, fax (201) 748-6008, e-mail: [email protected]. Limit of Liability/Disclaimer of Warranty:While the publisher and the author have used their best efforts in preparing this book, they make no representations or warranties with respect to the accu- racy or completeness of the contents of this book and specifically disclaim any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives or written sales materials.The advice and strategies contained herein may not be suit- able for your situation.You should consult with a professional where appropriate.
    [Show full text]
  • Sapporo Medical University 2004 – 2009
    RESEARCH ACTIVITIES OF SAPPORO MEDICAL UNIVERSITY 2004 – 2009 Hokkaido,Japan March 2010 RESEARCH ACTIVITIES OF SAPPORO MEDICAL UNIVERSITY 2004 – 2009 Edited by Committee for International Affairs and Medical Exchanges Sapporo Medical University Toshikazu Saito Neuropsychiatry, School of Medicine Shin Morioka English, Center for Medical Education Hiroki Takahashi Internal Medicine ( III ), School of Medicine Tsuyoshi Saito Obstetrics and Gynecology, School of Medicine Michiaki Yamakage Anesthesiology, Center for Medical Education Makoto Nemoto Liberal Arts and Sciences (English), School of Health Sciences Kimiharu Inui Applied Physical Therapy , Schhl of Health Sciences Contents ΣޓOUTLINE OF SAPPORO MEDICAL UNIVERSITYȤȤ!ȁ2 ޓޓޓޓޓPediatrics ȤȤȤȤȤȤȤȤȤȤȤȤȤȤȤȁ78 ޓ㧝ޓOUTLINE ȤȤȤȤȤȤȤȤȤȤȤȤȤȤȤȤȤ!ȁ3 ޓޓޓޓޓOphthalmology ȤȤȤȤȤȤȤȤȤȤȤȤȤȁ7: ޓޓޓޓޓDermatology ȤȤȤȤȤȤȤȤȤȤȤȤȤȤȁ82 ޓ㧞ޓORGANIZATION ȤȤȤȤȤȤȤȤȤȤȤȤȤȤ!ȁ6 ޓޓޓޓޓUrology ȤȤȤȤȤȤȤȤȤȤȤȤȤȤȤȤȁ84 ޓޓޓޓOrganization ȤȤȤȤȤȤȤȤȤȤȤȤȤȤȤ!ȁ6 ޓޓޓޓޓOtolaryngology ȤȤȤȤȤȤȤȤȤȤȤȤȤȁ86 ޓޓޓޓNumber of Teaching Staffs & Fellows ȤȤȤȤȤ!ȁ9 ޓޓޓޓޓNeuropsychiatry ȤȤȤȤȤȤȤȤȤȤȤȤȤȁ88 ޓޓޓޓNumber of Students ȤȤȤȤȤȤȤȤȤȤȤȤ!ȁ: ޓޓޓޓޓRadiology ȤȤȤȤȤȤȤȤȤȤȤȤȤȤȤȁ8: ޓޓޓޓޓAnesthesiology ȤȤȤȤȤȤȤȤȤȤȤȤȤȁ92 ΤޓRESEARCH ACTIVITIES ȤȤȤȤȤȤȤȤȤȤȤȤ!!22 ޓޓޓޓޓCommunity and General Medicine ȤȤȤȤȤȁ94 ޓ㧭ޓSCHOOL OF MEDICINE ȤȤȤȤȤȤȤȤȤȤȤ!!23 ޓޓޓޓޓClinical Laboratory Medicine ȤȤȤȤȤȤȤȤȁ96 ޓޓ㧝ޓMedical Sciences ȤȤȤȤȤȤȤȤȤȤȤȤȤȁ23 ޓޓޓޓޓTraumatology and Critical Care Medicine ȤȤȤȁ98 ޓޓޓޓޓObstetrics and Perinatal Medicine ȤȤȤȤȤȤȁ23 ޓޓޓޓޓOral Surgery ȤȤȤȤȤȤȤȤȤȤȤȤȤȤȁ9: ޓޓޓޓޓPlastic
    [Show full text]
  • List of Reviewers 2018–2019
    Journal of Bone and Mineral Metabolism (2019) 37:1107–1108 https://doi.org/10.1007/s00774-019-01065-1 © The Japanese Society Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2019 LIST OF REVIEWERS 2018–2019 I would like to thank the following individuals who have provided reviews during the past year. They have contributed very much to the success of the journal. Toshio Matsumoto M.D., Ph.D. Toshiyuki Yoneda D.D.S., Ph.D. Executive Advisor, Fujii Memorial Research Professor and Emeritus Professor Institute of Medical Sciences, Department of Biochemistry, Osaka University University of Tokushima, Tokushima, Japan Graduate School of Dentistry, Osaka, Japan On leave of absence from Indiana University School of Medicine, Indianapolis, IN, USA Editor-in-Chief Makoto Abe Paola Divieti Pajevic Chikahisa Higuchi Masako Ito Masahiro Abe Artemis Doulgeraki Toru Hiraga Nobuaki Ito Nobuo Adachi Emma L Duncan Rikako Hiramatsu Kazuyuki Itoh Ignacio Aguirre Kosuke Ebina Makoto Hirao Jun Iwamoto Ken-ichi Aihara Itsuro Endo Makoto Hirata Yoshiko Iwasaki Haruhiko Akiyama Naoto Endo Shintaro Hirata Takanori Iwata Matthew Allen Yoichi Ezura Osamu Honda Jean X. Jiang Elena Ambrogini José Luis Ferretti Keisuke Horiuchi Eijiro Jimi Takashi Ando Lars Folkestad Akihiro Hosoya Nobuhiko Joki Kazuhiro Aoki Hideki Fujii Lilian I. Plotkin Hyungjin Jung Takatoshi Aoki Naohiko Fujii Kousuke Iba Yuho Kadono Kiyoshi Aoyagi Akira Fujimori Tadahiro Iimura Takashi Kaito Hiroshi Asahara Ikuma Fujiwara Satoshi Ikeda Hiroshi Kaji Giampiero I. Baroncelli Makoto Fujiwara Mika Ikegame Takatoshi Kakuta Mark Bolland Saeko Fujiwara Masayuki Iki Ryutaro Kamijo Massimo Bottini Masafumi Fukagawa Fujiwara Ikuma Hiroshi Kamioka Lucas R Brun Kei Fukami Shiro Imagama Genta Kanai David B.
    [Show full text]
  • Program Subcommittee Member's List
    32nd ISTS Program Subcommittee Members’ List a) Session (Chemical Propulsion and Air-breathing Engines) Chairperson of the Committee Kenichi TAKAHASHI Nihon University Co-Chairperson Osamu IMAMURA Nihon University Kazuki SAKAKI JAXA Yu DAIMON JAXA Daisuke NAKATA Muroran Institute of Technology Ken MATSUOKA Nagoya University Hiroki MATSUNAGA Fukuoka University Kengo YAMAMOTO IHI Aerospace Cheng HUANG University of Michigan Justin HARDI DLR Filippo MAGGI Politecnico di Milano b) Session (Electric and Advanced Propulsion) Chairperson of the Committee Yoshinori NAKAYAMA National Defense Academy Co-Chairperson Akira KAKAMI University of Miyazaki Akira IWAKAWA Nagoya University Hiroshi KATSURAYAMA Yamaguchi University Kenichi KUBOTA JAXA Yoshinori TAKAO Yokohama National University Hiroyuki NISHIDA Tokyo Univ. of Agriculture and Technology Hiroki WATANABE Tokyo Metropolitan University Wonho CHOE KAIST Carsten SCHARLEMANN Fachhochschule Wiener Neustadt Tony SCHŐENHERR ENPULSION GmbH Guangqing XIA Dalian University of Technology c) Session (Materials and Structures) Chairperson of the Committee Jun KOYANAGI Tokyo University of Science Co-Chairperson Hiroaki TANAKA National Defense Academy Takeshi AKITA Chiba Institute of Technology Atsuhiko SENBA Meijo University Shin-ichi TAKEDA JAXA Ryousuke MATSUZAKI Tokyo University of Science Akinori YOSHIMURA Nagoya University d) Session (Astrodynamics, Navigation, Guidance and Control) Chairperson of the Committee Takehiro HIGUCHI Yokohama National University Co-Chairperson Mai BANDO Kyushu University
    [Show full text]
  • Kazuki Nagayama 1/2 Photographer
    Kazuki Nagayama 1/2 photographer Profile ： 2001 ： Joined AZABU STUDIO. 2004 ： Studied under Photographer Katsuhide Morimoto. 2007 ： Joined S-14. Editorial ： anan BAILA BRUTUS CLASSY. Domani ELLE japon Esquire FIGARO japon GINGER GINZA GISELe GLOW GQ JAPAN GRIND Forbes JAPAN Hanako HERS In Red JJ LEE LEON marie clair Marisol MAQUIA MEN'S CLUB MEN’S JOKER MEN’S NON-NO MEN'S Precious Milk MONOCLE MORE Numero TOKYO OCEANS Oggi otona MUSE Pen PERK POPEYE Precious PRODISM smart SPRiNG SPUR STORY SWAG HOMMES SWITCH Tarzan Them magazine UOMO VERY VOCE 25ans ＆ROSY EXILE Magazine so-en TOKYO-Calendar BITEKI Advertisement / Catalog ： aniary ato AVIREX BANANA REPUBLIC BASE MARK BEAMS BELSTAFF CALMANTHOLOGY CITIZEN DELUXE Discoat Parisien earth music&ecology EDIFICE ELENDEEK ESTNATION EYEVAN7258 FELISSIMO FOREVERMARK FRAY I.D GLOBAL WORK GU GUNZE G.V.G.V HEADPORTER IENA JUN ASHIDA KATHARINE HAMNETT LONDON KIJIMA TAKAYUKI KONAKA THE FLAG LONNER LUIGI BORRELLI MARGARET HOWELL MEN'S BIGI MELLSAVON Mila Owen NEIGHBORHOOD NEPENTHES NOBLE ONLY Right-on RIM.ARK ROPÉ Roppongi Hills SHIPS SLY SOPH. SUIT SELECT Theory TOMORROWLAND TOYOTA UNITED ARROWS UNIQLO URBAN RESEARCH Wacoal White Mountaineering YLEVE ISETAN NIPPON-TV HOLLYWOOD COSMETICS HANKYU DEPARTMENT STORES MARUI 2/2 Celebrity ： YU AOI GO AYANO HARUKA IGAWA YUSUKE ISEYA MIWAKO ICHIKAWA HAYATO ICHIHARA GORO INAGAKI EITA NENE OTUKA JUNICHI OKADA MASAKI OKADA SHUN OGURI JOE ODAGIRI RYO KATSUJI HARUNA KAWAGUCHI KITAGAWA KEIKO TAKUYA KIMURA KENTA KIRITANI MIREI KIRITANI YOSUKE KUBOZUKA KENGO KOURA AYAME
    [Show full text]
  • FY 2019 Q1 Briefing on the Operating Results 2018.7.13
    FY 2019 Q1 Briefing on the Operating Results 2018.7.13 DIP Corporation (First section of the Tokyo Stock Exchange code 2379) 1 Copyright © 2018 DIP Corporation, All Rights Reserved. CONTENTS 1 FY2019 Q1 Summary of Consolidated Results 2 2 FY2019 Q1 Business Performance 7 3 Q1 Summary and Strategies for FY2019 14 ４ Appendix 21 Copyright © 2018 DIP Corporation, All Rights Reserved. 1 CONTENTS 1 FY2019 Q1 Summary of Consolidated Results We have shifted to consolidated accounts from the FY2017 Q3 consolidated cumulative period. Although we do not conduct a comparative analysis with the cumulative period of the previous quarter, as reference, the figures and change rates compared with individual accounts for the same quarter of the previous year are stated. Copyright © 2018 DIP Corporation, All Rights Reserved. 2 FY2019 Q1 Summary of Consolidated Results Both sales and operating profit remained strong. Market conditions ・The effective job offering ratio is the highest level in about 44 years and the job trends are strong. ・The unemployment rate is the lowest level for the first time in 25 years and 7 months. Business environment of Personnel Recruiting Services Division ・Contract number of companies · Number of job advertisement postings increased in Baitoru · Baitoru NEXT · Hatarako.net , and sales growth continues. Operating profit is also steady. ・In Nurse de Hatarako maintains a surplus, despite a decrease in revenue due to proper allocation of personnel in the previous term. Copyright © 2018 DIP Corporation, All Rights Reserved. 3 ■Effective
    [Show full text]
  • Acknowledgments to Referees 2019
    Acknowledgments to Referees We would like to express our thanks to the following individuals for their continuing support in reviewing manuscripts submitted to the Transactions of JSASS, Aerospace Technology Japan Vol. 16, 2018 and Vol. 17, 2019. Editor-in-Chief Susumu TERAMOTO and the Editorial Board Members 31st ISTS Editorial Board Members Takumi ABE Yanning GUO Hiroyasu ISHIKAWA Ryojiro AKIBA Oskar J. HAIDN Shinji ISHIMOTO Takeshi AKITA Yoshiro HAMADA Kosei ISHIMURA Sumiko ANNOU Naokazu HAMAMOTO Noriaki ITOGA Shigeyuki AOKI Kenya HARADA Akira IWAKAWA Takuya AOKI Makoto HAREYAMA Akira IWASAKI Takakage ARAI Atsushi HASHIMOTO Minoru IWATA Hitoshi ASANO Tomoaki HASHIMOTO Takanori IWATA Mai BANDO Hidehiro HATA Yoko IWATA Nobutaka BANDO Ryuta HATAKENAKA Ichiro JIKUYA Daniele BIANCHI Kenji HAYAMA Akira KAKAMI Elisabet CANALIAS Masumi HIGASHIDE Toshihiro KAMEDA Hongru CHEN Ken HIGUCHI Sayaka KANATA Yen-Sen CHEN Takehiro HIGUCHI Masahiro KANAZAKI Kazuhisa CHIBA Takehiro HIMENO Koji KANETAKE Shinatora CHO Tetsuo HIRAIWA Haruyoshi KATAYAMA Takahiro FUJIKAWA Keiichi HIRAKO Naomi KATAYAMA Kenji FUJIMOTO Chikako HIROSE Toshiyuki KATSUMI Yoshiyuki FUJINO Shinji HOKAMOTO Hiroshi KATSURAYAMA Kazuhisa FUJITA Kazuhiko HONJO Nobuaki KAWAI Koki FUJITA Shuusuke HORI Taro KAWANO Katsuyoshi FUKIBA Tsutomu ICHIKAWA Rei KAWASHIMA Seisuke FUKUDA Tamotsu IGARASHI Sajjad KESHTKAR Yosuke FUKUSHIMA Toshiaki IIZUKA Masao KIKUCHI Ikkoh FUNAKI Satoshi IKARI Sangkyun KIM Yuki FUNAMI Hitoshi IKEDA Yugo KIMOTO Masato FUNATSU Taro IMAMURA Masaya KIMURA Katsuhito GOTO
    [Show full text]
  • Kerala State Chalachitra Academy Department of Cultural Affairs Government of Kerala
    Kerala State Chalachitra Academy Department of Cultural Affairs Government of Kerala Recognised by Fédération Internationale des Associations de Producteurs de Films International Federation of Film Producers Associations THE FESTIVAL TEAM Chairman & Festival Director, IFFK: Kamal Vice-Chairperson & Artistic Director, IFFK: Bina Paul Secretary & Executive Director, IFFK: Mahesh Panju Treasurer: Y Muhammad Rijam Deputy Director (Festival): H Shaji Deputy Director (Programmes): N P Sajeesh Programme Manager (Finance): Sajith C C Programme Manager (Programmes): Vimal Kumar V P Manager (Technical): Gopeekrishna S Print Unit Coordinator: P S Siva Kumar State Coordinator, Touring Talkies: Rijoy K J Festival Programme Assistants: Tony Xavier, Saiyed Farooq Festival Assistants: Madhavi Madhupal, Sree Vidya J Festival Cell: K Velayudhan Nair,Mary Ninan, K Venukuttan Nair, K Ravikumar, P Padmakumar, K Harikumar, Vijayamohan B, J Sukumaran, D Jayakumari, Jaya L, G Sasikala, John Kurian, Lizy M, Nishanth ST, Sandhya B, Arun R, Abhilash N S, Naveen L Johnson, Shamlal S, Abdulla, Shyam, Manu Madhavan, Vishnu Prashanth Guest Relations and Hospitality Trivi Art Concerns Bandhu Prasad-Aleyamma, Arjun A, Shelly J Morais, Rameez Mohammed, Jithin Mohan AS, Vishnu VI Media Relations Officer: B T Anilkumar Screening Schedule: Geethanjali Harikumar Technical Screening & KDM Management: Prasad Khatu Website Support: Satheesh S, Shajith R B, Girish KumarVS (C-DIT) Software Support: C-DIT Design Concept: B Priyaranjanlal Signature Film: Arun Sreepadam FESTIVAL BOOK Chief Editor: Mahesh Panju, Secretary, KSCA Executive Editor: Jithin KC Editorial Team: Dr. Sangeetha C, Nisam Asaf, Nidhin Nath, Anees Hassan, Aiswaria N, Goutham, Adila Kabeer, Nikhil R, Abhijith S, Goutham K, Anagha, Arundhathi, Arya Babu, Meenakshi J, Sayanth Page Design & Layout: Joby Ravindran Word Processing & Page Setting: Sivaprasad B Academy is grateful to various film journals, festival publications, Film Festival websites from which we have borrowed materials to put together this book.
    [Show full text]
  • PROCEEDINGS of the TWENTY-FIFTH INTERNATIONAL SYMPOSIUM on SPACE TECHNOLOGY and SCIENCE ( Selected Papers )
    PROCEEDINGS OF THE TWENTY-FIFTH INTERNATIONAL SYMPOSIUM ON SPACE TECHNOLOGY AND SCIENCE ( Selected Papers ) KANAZAWA 2006 JSASS and ISTS CONTENTS-.•••.— .—••. •-.•-. Title/Authors ,!T,;, Paper No. Page Development and Results of Space Evaluation Test for Vane Type Tank 2006-a-02 1 System(VTS)- - • ' - .-.-i s--»'o-. : .•;-..:-,,-i::v».3C.; lo f-:;jiiij,,<:"i Ryoji Imai, Yosuke Takano, Keisuke Yamada, Kazunor Hama, Shuji Nakamura '•- -i'-:y:••--'. K: ,: < "irki f ,»!rna>i ii;;ii.r:?t> • Experimental Investigation of the Dynamic Characteristics of Lateral Liquid <•) c2006-a-03>*J ;in;i>K6; Sloshing in a Concentric Membrane Tank ix?/iHn>rtV M:r, <:V.-"V; -.: -r, ;;,: ir.ciiqr!'1. - Keiji Komatsu, Miki Nishimoto • ' • ' ''' . <""i •.".• i^an'. ,o."-.. '.=u-..-. i.-i-'...r.;! i, r ,.,.,,;. :'«:;.'J! .viiiii3Li!.«i Numerical Analysis of Dynamic Behavior of Free-Surface Flows in Tanks 2006-a-04 13 Based on CIPH.SM -'••: -V^' '•• -^ • •"' •- " ' •'•• ••-t- :,••>::,:.-••--h^; Hideyo Negishi, Takehiro Himeno, Nobuhiro Yamanishi : r '-.' - ":?.«.• Development of Numerical Methods for Propellant Management 2006-a-06 19 Takehiro Himeno, Toshinori Watanabe, Ryoji Imai •'•••" ' '"-'•'•'• -'' Cryogenic Propellant Management of H- IIA Upper Stage 2006-a-08 29 Osamu Kitayama, Iwao Igarashi, Tatsuru Tokunaga, Koichi Okita, Masumi Fujita Characteristics of Flows and Discharge Coefficients in Coaxial Injectors with 2006-a-13 '35 Cold Flow Tests Yoshio Nunome, Hiroshi Sakamoto, Takuo Onodera, Hiroshi Tamura, Takao Inamura, Akinaga Kumakawa •' ' ; ' ' Performance Evaluations of the Methane Fueled Rocket Nozzles under High 2006-a-18 41 Altitude Conditions . " . : Takashi Ito, Akinaga Kumakawa, Keiichi Hasegawa, Masaki Sato, Shinichi Moriya, Kazuo Kusaka, Masahiro Sato, Makoto Tadano . ... • . .. ... Flow Separation and the Associated Side-Load Origin in a Thrust Optimized 2006-a-2Q , 47, Parabolic Nozzle Shashi Verma, Oskar, Haidn .
    [Show full text]
  • Japan Society Announces Full Lineup for JAPAN CUTS: Festival of New Japanese Film
    Media Contacts: Caitlin Hughes, 973-970-4689 [email protected] Michele Debreceni, 212-715-1228 [email protected] Japan Society Announces Full Lineup for JAPAN CUTS: Festival of New Japanese Film 12th Edition Includes Over 30 Films Never Before Seen in NYC, With Unprecedented Number of Special Guests, Including Awardee Kirin Kiki July 19-29, 2018, at Japan Society New York, NY (June 11, 2018) – Japan Society announces the full lineup of the 12th annual JAPAN CUTS: Festival of New Japanese Film. Described by The New York Times as “meticulously curated” and “an annual highlight of New York’s film calendar,” the summer festival brings a wide range of the best and hardest-to-see films made in and around Japan today—from blockbusters, independent productions and anime, to documentaries, avant-garde works, short films, and new restorations. This year’s edition spans ten days — from July 19 through July 29 — and features 28 feature-length films and 9 short films across the Feature Slate, Classics: Rediscoveries and Restorations, Documentary Focus, and Experimental Spotlight sections. Among them are 3 World Premieres, 3 International Premieres, 11 North American Premieres, 8 U.S. Premieres, 3 East Coast Premieres, and 7 New York Premieres. In addition, JAPAN CUTS 2018 boasts the most confirmed guest filmmakers, actors, and producers in the festival’s history, many visiting New York with films for the first time. As previously announced, the festival is proud to honor the beloved actress Kirin Kiki with this year’s CUT ABOVE Award for Outstanding Performance in Film. An industry veteran with over 50 years of screen credits behind her, Kiki is recognized today as one of her generation’s leading talents.
    [Show full text]
  • Full PDF Download
    h.p://www.cellr4.org Editor in Chief Camillo Ricordi Cell Transplant Center and Diabetes Research Ins%tute, University of Miami, Miami, FL, USA Associate Editor for Asia Jianming Tan Fuzhou General Hospital, Xiamen University, China Assistant Editor Antonello Pileggi Cell Transplant Center and Diabetes Research Ins%tute, University of Miami, Miami, FL, USA Verduci Internaonal LLC Miami, Florida, USA http://www.cellr4.org - e-mail: [email protected] Editorial Office ([email protected]) Editorial Office Director Patrizia Verduci Editorial Office Deputy Directors Gianni Lombardi and Mariella Verduci Editorial Office Assistant Valen-na Doria CellR4 – Repair, Replacement, Regenera-on & Reprogramming Official Journal of The Cure Alliance Copyright © 2013 Verduci Interna%onal Miami, Florida, USA Editorial Board Reza Abdi Bruno Gridelli Harvard Medical School, Boston, MA, USA ISMETT, Palermo, Italy Rodolfo Alejandro Joshua M. Hare University of Miami, Miami, FL, USA University of Miami, Miami, FL, USA Julie G. Allickson Karin Hehenberger Wake Forest University, Winston-Salem, NC, USA Karolinska Institutet, Stockholm, Sweden Piero Anversa Jeffrey A. Hubbell Harvard Medical School, Boston, MA, USA Swiss Federal Institute of Technology (EPFL), Lausanne, CH Anthony Atala Suzanne Ildstad Wake Forest University, Winston-Salem, NC, USA University of Louisville, Louisville, KY Per-Olof Berggren Luca Inverardi Karolinska Institutet, Stockholm, Sweden University of Miami, Miami FL, USA Federico Bertuzzi Jonathan Lakey University of California Irvine, Irvine, CA, USA Ospedale Niguarda Ca' Granda, Milan, Italy Robert Langer Tiziana Brevini MIT and Harvard Medical School, Boston, MA, USA Università degli Studi di Milano, Milan, Italy Livio Luzi F. Charles Brunicardi Università degli Studi di Milano, Milan, Italy University of California at Los Angeles, Mario Marazzi Los Angeles, CA, USA Peter Buchwald Ospedale Niguarda Ca' Granda, Milan, Italy Claudia Montero-Menei University of Miami, Miami, FL, USA University of Angers, Angers, France Richard K.
    [Show full text]