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Annual Report 2019 of the Institute of Medical Science, the University of Tokyo (IMSUT)

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Annual Report 2019 of the Institute of Medical Science, the University of Tokyo (IMSUT) Preface It is our pleasure to present Annual Report 2019 of the Institute of Medical Science, The University of Tokyo (IMSUT). The predecessor organization of IMSUT was founded in 1892 as the Institute of Infectious Diseases (IID) by Dr. Shibasaburo Kitasato and incorpo- rated into the University of Tokyo in 1916. In that era, infectious diseases were the great- est threat to public health and the IID was the center for research into infectious diseases in Asia and a top center for the world, as well. In 1967, this institute received its present name when we reorganized it to encompass a wider range of medical sciences to meet the demands of modern medical care after World War II. Now, based on a history and tradition of over 128 years since the IID’s foundation, IMSUT’s mission has grown to contribute to the development and welfare of human society through research in cutting-edge medical science and the implementation of state-of-the-art medical care. To achieve this mission, IMSUT promotes interdiscipli- nary research and develops it into a wide range of practical applications, from the estab- lishment of artificial intelligence, AI, supporting the most advanced AI medical care, to the development of drugs, including gene, virus, and vaccine therapies, cell and organ transplantation using stem cells and iPS cells, and new dimensions of genomic medicine. For over a century, IMSUT has handed down the three guiding principles established by Dr. Shibasaburo Kitasato: “practical studies” which benefit society; diverse and inclu- sive “comprehensive research;” and “disease prevention.” Together, these three principles form the basis of healthcare, and remain the foundation of our rapidly developing cur- rent research. IMSUT is pioneering new intellectual horizons by efficiently utilizing an enormous quantity of information with AI. We are accelerating the efficient utilization of this new technology, as we promote the establishment of AI for medical science research with our specialized supercomputer, “SHIROKANE”, which has already led to AI medi- cal care for hematopoietic tumors in our in-house hospital. Importantly, IMSUT was authorized in 2018 as the only International Joint Usage/Re- search Center serving the life science field by the Minister of Education, Culture, Sports, Science and Technology, Japan. By utilizing this platform, we are supporting 22 interna- tional joint research projects in fiscal year 2019. As a world-leading medical science insti- tute, we fervently desire to further contribute to the development of global communities of basic, translational, and clinical research. This annual report summarizes our scientific achievements in 2019. I sincerely hope that these achievements will inspire yet further advances, promote worldwide collabora- tions with our scientists, and ultimately contribute to improve health care around the world. January 2020 Yuji Yamanashi, Ph.D. Dean The Institute of Medical Science The University of Tokyo Preface（21）.indd 1 2020/05/22 10:39:25 1 Organization and Faculty Members 機構および職員 〈as of December, 2019〉 Department of Microbiology and Immunology 感染・免疫部門 Division of Virology �������������������������������������� 18 ウイルス感染分野 Professor Yoshihiro Kawaoka, D.V.M., Ph.D. 教 授 獣医学博士 河 岡 義 裕 Associate Professor Masaki Imai, D.V.M., Ph.D. 准教授 博士（獣医学） 今 井 正 樹 Project Associate Professor Tokiko Watanabe, D.V.M., Ph.D. 特任准教授 博士（獣医学） 渡 邉 登喜子 Project Associate Professor Seiya Yamayoshi, D.V.M., Ph.D. 特任准教授 博士（医学） 山 吉 誠 也 Assistant Professor Kiyoko Iwatsuki-Horimoto, D.V.M., Ph.D. 助 教 博士（獣医学） 岩附（堀本）研子 Assistant Professor Shinya Yamada, Ph.D. 助 教 博士（医学） 山 田 晋 弥 Project Assistant Professor Maki Kiso, D.V.M., Ph.D. 特任助教 博士（医学） 木 曽 真 紀 Research Associate Yuko Sakai-Tagawa, Ph.D. 助 手 博士（医学） 坂井（田川）優子 Division of Infectious Genetics�������������������������������� 23 感染遺伝学分野 Professor Kensuke Miyake, M.D., Ph.D. 教 授 医学博士 三 宅 健 介 Associate Professor Shin-Ichiroh Saitoh, Ph.D. 准教授 博士（医学） 齋 藤 伸一郎 Assistant Professor Ryutaro Fukui, Ph.D. 助 教 博士（医学） 福 井 竜太郎 Assistant Professor Takuma Shibata, Ph.D. 助 教 博士（医学） 柴 田 琢 磨 Project Assistant Professor Ryota Sato, Ph.D. 特任助教 博士（医学） 佐 藤 亮 太 Division of Molecular Virology�������������������������������� 26 ウイルス病態制御分野 Professor Yasushi Kawaguchi, D.V.M., Ph.D. 教 授 博士（獣医学） 川 口 寧 Assistant Professor Akihisa Kato, Ph.D. 助 教 博士（医学） 加 藤 哲 久 Assistant Professor Jun Arii, Ph.D. 助 教 博士（獣医学） 有 井 潤 Assistant Professor Naoto Koyanagi, Ph.D. 助 教 博士（生命科学） 小 栁 直 人 Project Assistant Professor Yuhei Maruzuru, Ph.D. 特任助教 博士（生命科学） 丸 鶴 雄 平 Division of Vaccine Science ��������������������������������� 28 ワクチン科学分野 Professor Ken J. Ishii, M.D., Ph.D. 教 授 医学博士 石 井 健 Associate Professor Kouji Kobiyama, Ph.D. 准教授 博士（医学） 小檜山 康 司 Project Senior Assistant Professor Hideo Negishi, Ph.D. 特任講師 博士（医学） 根 岸 英 雄 Assistant Professor Burcu Temizoz, Ph.D. 助 教 博士（医学） テミズオズ ブルジュ ●Annual Report.indb 1 2020/05/22 10:48:48 2 Division of Malaria Immunology ������������������������������� 31 マラリア免疫学分野 Professor Cevayir Coban, M.D., Ph.D. 教 授 博士（医学） チョバン ジェヴァイア Department of Cancer Biology 癌・細胞増殖部門 Division of Molecular Pathology������������������������������� 33 人癌病因遺伝子分野 Professor Yoshinori Murakami, M.D., Ph.D. 教 授 医学博士 村 上 善 則 Project Professor Takayuki Morisaki, M.D., Ph.D. 特任教授 医学博士 森 崎 隆 幸 Assistant Professor Takeshi Ito, Ph.D. 助 教 博士（医学） 伊 東 剛 Division of Cellular and Molecular Biology������������������������� 37 分子発癌分野 Professor Jun-ichiro Inoue, Ph.D. 教 授 薬学博士 井 上 純一郎 Associate Professor Takeharu Sakamoto, Ph.D. 准教授 博士（医学） 坂 本 毅 治 Assistant Professor Mizuki Yamamoto, Ph.D 助 教 博士（医学） 山 本 瑞 生 Division of Genetics�������������������������������������� 41 腫瘍抑制分野 Professor Yuji Yamanashi, Ph.D. 教 授 理学博士 山 梨 裕 司 Assistant Professor Ryo Ueta, Ph.D. 助 教 博士（生命科学） 植 田 亮 Assistant Professor Akane Inoue-Yamauchi, Ph.D. 助 教 博士（医学） 山内（井上） 茜 Assistant Professor Takahiro Eguchi, Ph.D. 助 教 博士（科学） 江 口 貴 大 Division of Cancer Cell Biology ������������������������������� 46 癌防御シグナル分野 Professor Makoto Nakanishi, M.D., Ph.D. 教 授 医学博士 中 西 真 Associate Professor Atsuya Nishiyama, Ph.D. 准教授 博士（理学） 西 山 敦 哉 Assistant Professor Yoshikazu Johmura, Ph.D. 助 教 博士（薬学） 城 村 由 和 Department of Basic Medical Sciences 基礎医科学部門 Division of Neuronal Network �������������������������������� 49 神経ネットワーク分野 Professor Toshiya Manabe, M.D., Ph.D. 教 授 医学博士 真 鍋 俊 也 Assistant Professor Hiroyuki Katagiri, Ph.D. 助 教 博士（医学） 片 桐 大 之 Assistant Professor Shizuka Kobayashi, Ph.D. 助 教 博士（生命科学） 小 林 静 香 Assistant Professor Takahiko Chimura, Ph.D. 助 教 博士（理学） 千 村 崇 彦 Division of Cell Signaling and Molecular Medicine��������������������� 51 分子シグナル制御分野 Professor Mutsuhiro Takekawa, M.D., Ph.D. 教 授 博士（医学） 武 川 睦 寛 Assistant Professor Yuji Kubota, Ph.D. 助 教 博士（理学） 久保田 裕 二 Assistant Professor Takanori Nakamura, Ph.D. 助 教 博士（理学） 中 村 貴 紀 ●Annual Report.indb 2 2020/05/22 10:48:48 3 Human Genome Center ヒトゲノム解析センター Laboratory of DNA Information Analysis �������������������������� 55 DNA 情報解析分野 Laboratory of Sequence Analysis シークエンスデータ情報処理分野 Laboratory of Genome Database ゲノムデータベース分野 Professor Satoru Miyano, Ph.D. 教 授 理学博士 宮 野 悟 Assistant Professor Yao-zhong Zhang, Ph.D. 助 教 博士（情報理工学） Yao-zhong Zhang Associate Professor Tetsuo Shibuya, Ph.D. 准教授 博士（理学） 渋 谷 哲 朗 Assistant Professor Kotoe Katayama, Ph.D. 助 教 博士（工学） 片 山 琴 絵 Project Assistant Professor Taku Onodera, Ph.D. 特任助教 博士（情報理工学） 小 野 寺 拓 Laboratory of Molecular Medicine������������������������������ 64 ゲノム医科学分野 Professor Tatsuhiro Shibata, M.D., Ph.D. 教 授 医学博士 柴 田 龍 弘 Senior Assistant Professor Atsushi Niida, Ph.D. 講 師 博士（理学） 新井田 厚 司 Assistant Professor Satoshi Yamasaki, Ph.D. 助 教 博士（農学） 山 唎 智 Laboratory of Genome Technology ����������������������������� 66 シークエンス技術開発分野 Professor Satoru Miyano, Ph.D. 教 授 理学博士 宮 野 悟 Professor Koichi Matsuda, M.D., Ph.D. 連携教授 博士（医学） 松 田 浩 一 （新領域創成科学研究科） Assistant Professor Chizu Tanikawa, Ph.D. 助 教 博士（医学） 谷 川 千 津 Laboratory of Functional Analysis In Silico������������������������� 74 機能解析イン・シリコ分野 Professor Kenta Nakai, Ph.D. 教 授 博士（理学） 中 井 謙 太 Senior Assistant Professor Ashwini Patil, Ph.D. 講 師 博士（理学） パティル、アシュウィニ Project Senior Assistant Professor Sung-Joon Park, Ph.D. 特任講師 博士（工学） 朴 聖 俊 Department of Public Policy ��������������������������������� 79 公共政策研究分野 Professor Kaori Muto, Ph.D. 教 授 博士（保健学） 武 藤 香 織 Associate Professor Yusuke Inoue, Ph.D. 准教授 博士（社会医学） 井 上 悠 輔 Project Assistant Professor Akiko Nagai, Ph.D. 特任助教 博士（医科学） 永 井 亜貴子 Center for Experimental Medicine and Systems Biology システム疾患モデル研究センター Division of Stem Cell Pathology ������������������������������� 82 先進病態モデル研究分野 Professor Yasuhiro Yamada, M.D., Ph.D. 教 授 博士（医学） 山 田 泰 広 Assistant Professor Sho Ohta, Ph.D. 助 教 博士（生命科学） 太 田 翔 ●Annual Report.indb 3 2020/05/22 10:48:48 4 Laboratory of Innate Immunity�������������������������������� 84 自然免疫研究分野 Professor Kensuke Miyake, M.D., Ph.D. 教 授 医学博士 三 宅 健 介 Laboratory of Reproductive Systems Biology ����������������������� 86 生殖システム研究分野 Project Professor Masahito Ikawa, Ph.D. 特任教授 博士（薬学） 伊 川 正 人 Associate Professor Manabu Ozawa, Ph.D. 准教授 博士（農学） 小 沢 学 Laboratory of Systems Biology ������������������������������� 89 システムズバイオロジー研究分野 Associate Professor Susumu Nakae, Ph.D. 准教授 博士（農学） 中 江 進 Division of Genome Engineering� ������������������������������ 91 ゲノム編集研究分野 Professor Tomoji Mashimo, Ph.D.
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