A Recruiting Protein of Geranylgeranyl Diphosphate Synthase Controls Metabolic Flux Toward Chlorophyll Biosynthesis in Rice
A recruiting protein of geranylgeranyl diphosphate synthase controls metabolic flux toward chlorophyll biosynthesis in rice Fei Zhoua,1, Cheng-Yuan Wangb,1, Michael Gutensohnc,1, Ling Jiangd, Peng Zhangb, Dabing Zhange, Natalia Dudarevaf,2, and Shan Lua,2 aState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China; bState Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China; cDivision of Plant and Soil Sciences, West Virginia University, Morgantown, WV 26505; dState Key Laboratory of Crop Genetics and Germplasm Enhancement, Research Center of Jiangsu Plant Gene Engineering, Nanjing Agricultural University, Nanjing 210095, China; eState Key Laboratory of Hybrid Rice, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; and fDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907 Edited by Joanne Chory, The Salk Institute for Biological Studies and Howard Hughes Medical Institute, La Jolla, CA, and approved May 18, 2017 (received for review April 6, 2017) In plants, geranylgeranyl diphosphate (GGPP) is produced by is shared by several vital metabolic pathways, particularly in plastidic GGPP synthase (GGPPS) and serves as a precursor for vital plastids, including the biosynthesis of carotenoids and their deriv- metabolic branches, including chlorophyll, carotenoid, and gibber- atives (e.g., plant hormones abscisic acid and strigolactones), as ellin biosynthesis. However, molecular mechanisms regulating GGPP well as gibberellins, plastoquinones, tocopherols, and the phytyl tail allocation among these biosynthetic pathways localized in the same of chlorophylls (3). However, it remains largely unknown how al- subcellular compartment are largely unknown.
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