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RAIL OPERATORS' REPORTING MARKS February 24, 2010 a AA
RAIL OPERATORS' REPORTING MARKS February 24, 2010 A AA ANN ARBOR AAM ASHTOLA AND ALLEGHENY MOUNTAIN AB ATLANTIC AND BIRMINGHAM RAILWAY ABA ATLANTA, BIRMINGHAM AND ATLANTIC ABB AKRON AND BARBERTON BELT RAILROAD ABC ATLANTA, BIRMINGHAM AND COAST ABL ALLEYTON AND BIG LAKE ABLC ABERNETHY-LOUGHEED LOGGING COMPANY ABMR ALBION MINES RAILWAY ABR ARCADIA AND BETSEY RIVER ABS ABILENE AND SOUTHERN ABSO ABBEVILLE SOUTHERN RAILWAY ABYP ALABAMA BY-PRODUCTS CORP. AC ALGOMA CENTRAL ACAL ATLANTA AND CHARLOTTE AIR LINE ACC ALABAMA CONSTRUCTION COMPANY ACE AMERICAN COAL ENTERPRISES ACHB ALGOMA CENTRAL AND HUDSON BAY ACL ATLANTIC COAST LINE ACLC ANGELINA COUNTY LUMBER COMPANY ACM ANACONDA COPPER MINING ACR ATLANTIC CITY RAILROAD ACRR ASTORIA AND COLUMBIA RIVER ACRY AMES AND COLLEGE RAILWAY ACTY AUSTIN CITY RAILROAD ACY AKRON, CANTON AND YOUNGSTOWN ADIR ADIRONDACK RAILWAY ADPA ADDISON AND PENNSYLVANIA RAILWAY AE ALTON AND EASTERN AEC ATLANTIC AND EAST CAROLINA AER ANNAPOLIS AND ELK RIDGE RAILROAD AF AMERICAN FORK RAILROAD AG ATLANTIC AND GULF RAILROAD AGR ALDER GULCH RAILROAD AGP ARGENTINE AND GRAY'S PEAK AGS ALABAMA GREAT SOUTHERN AGW ATLANTIC AND GREAT WESTERN AHR ALASKA HOME RAILROAD AHUK AHUKINI TERMINAL RAILWAY AICO ASHLAND IRON COMPANY AJ ARTEMUS-JELLICO RAILROAD AK ALLEGHENY AND KINZUA RAILROAD AKC ALASKA CENTRAL AKN ALASKA NORTHERN AL ALMANOR ALBL ALAMEDA BELT LINE ALBP ALBERNI PACIFIC ALBR ALBION RIVER RAILROAD ALC ALLEN LUMBER COMPANY ALCR ALBION LUMBER COMPANY RAILROAD ALGC ALLEGHANY CENTRAL (MD) ALLC ALLEGANY CENTRAL (NY) ALM ARKANSAS AND LOUISIANA -
Liicycle PARADE L'abbing Ihkougil PARK PLAZA Fnlkancl THIRTY-FIFTH
-- -- liICYCLE PARADE l'AbbING IHKOUGIl PARK PLAZA FNlKANCl THIRTY-FIFTH ANNUAL REPORT OF THE CITY OF BROOKLYN AND THE FIRST OF THE COUNTY OF KINGS FOR THE YEAR 1895 BROOKLYN PRINTED FOR THE COMMISSIONER THE OFFICIAL LIST. Commissioner, FRANK SQUIER. Deputy Commissioner, HENRY L. PALMER. Secretary, JOHN EDWARD SMITII, General Superintendent, RUDOLPH ULRICH. Landscape Architects, Advisory, OLMSTED, OLMSTED & ELIOT. Paymaster, ROBERT H. SMITH. Assistant Paymaster, OSCAR C. WHEDON. Property and Labor Clerk, WILLIAM A. BOOTH. Stenographer, MAY G. HAMILTON. THECOMMISSIONER~S REPORT OF THE WORK OF THE DURINGTHE YEAR 1895. OFIJICE OF THE COMMISSIONEROF THE DEPARTMENTOF PARKS, " LITCHFIELD MANSION,"PROSPECT PARK, BROOI~LYN,January st, 1896. To the Honorable, the Common Council : GENTLEMEN-I have the honor herewith to submit to your Honorable Body my Annual Report concerning the care of the Parks and Parkways of the City of Brooklyn and of the County of Kings, which have been under my charge during the year 1895. There have been more than the usual developments in the way of care and improvement of the parks, and in addition there has been an acquisition of property which doubles the area of park lands existing at the beginning of the year, thus placing the city somewhat on a par with other great cities of the country. Steps have also been taken in the direction of increas- ing the pleasure drives, and the County now owns nearly all the property needed for the creation of the most charming drive in the world-the Hay Ridge Parkway, or, as it is popularly called, the Shore Drive. -
The Bulletin RAYMOND R
ERA BULLETIN — APRIL, 2016 The Bulletin Electric Railroaders’ Association, Incorporated Vol. 59, No. 4 April, 2016 The Bulletin RAYMOND R. BERGER, 1941-2016 Published by the Electric by Eric R. Oszustowicz Railroaders’ Association, Incorporated, PO Box On March 1, 2016, Raymond R. Berger corresponded regularly. In addition, the pho- 3323, New York, New York 10163-3323. passed away at age 74. He was an ERA tographic results of his travels were shared member since 1958. Ray will be missed by through countless presentations at which he us all. Ray was on the ERA’s Board of Direc- would educate attendees through meticulous For general inquiries, tors for many years and also served for a narration regarding the transit systems dis- contact us at bulletin@ time as the Chairman of its New York Divi- played. erausa.org. ERA’s website is sion when it was still operationally independ- Ray was a retired transit professional and www.erausa.org. ent. was a respected member of NYCT’s Division To state that Ray performed work for the of Car Equipment. Think of Ray the next time Editorial Staff: ERA is quite an understate- you ride an R-142 or R- Editor-in-Chief: ment. All who perform work 142A since he contributed to Bernard Linder Tri-State News and for the ERA do so on a their basic design. Commuter Rail Editor: strictly volunteer basis. Ray Ray was a religious man. Ronald Yee was an extremely busy indi- He attained secular mem- North American and World vidual with many interests, bership in the Third Order of News Editor: Alexander Ivanoff but he was always available St. -
Barbara Mcclintock's World
Barbara McClintock’s World Timeline adapted from Dolan DNA Learning Center exhibition 1902-1908 Barbara McClintock is born in Hartford, Connecticut, the third of four children of Sarah and Thomas Henry McClintock, a physician. She spends periods of her childhood in Massachusetts with her paternal aunt and uncle. Barbara at about age five. This prim and proper picture betrays the fact that she was, in fact, a self-reliant tomboy. Barbara’s individualism and self-sufficiency was apparent even in infancy. When Barbara was four months old, her parents changed her birth name, Eleanor, which they considered too delicate and feminine for such a rugged child. In grade school, Barbara persuaded her mother to have matching bloomers (shorts) made for her dresses – so she could more easily join her brother Tom in tree climbing, baseball, volleyball, My father tells me that at the and football. age of five I asked for a set of tools. He My mother used to did not get me the tools that you get for an adult; he put a pillow on the floor and give got me tools that would fit in my hands, and I didn’t me one toy and just leave me there. think they were adequate. Though I didn’t want to tell She said I didn’t cry, didn’t call for him that, they were not the tools I wanted. I wanted anything. real tools not tools for children. 1908-1918 McClintock’s family moves to Brooklyn in 1908, where she attends elementary and secondary school. In 1918, she graduates one semester early from Erasmus Hall High School in Brooklyn. -
I. Hox Genes 2
School ofMedicine Oregon Health Sciences University CERTIFICATE OF APPROVAL This is certify that the Ph.D. thesis of WendyKnosp has been approved Mentor/ Advisor ~ Member Member QUANTITATIVE ANALYSIS OF HOXA13 FUNCTION IN THE DEVELOPING LIMB By Wendy M. lt<nosp A DISSERTATION Presented to the Department of Molecular and Medical Genetics and the Oregon Health & Science University School of Medicine in partial fulfillment of the requirements for the degree of Doctor of Philosophy August 2006 TABLE OF CONTENTS LIST OF FIGURES iv LIST OF ABBREVIATIONS vii ACKNOWLEDGEMENTS X ABSTRACT xii CHAPTER 1: Introduction 1 I. Hox genes 2 A. Discovery of Hox genes in Drosophila melanogaster 2 B. Hox cluster colinearity and conservation 7 C. Human Hox mutations 9 D. Hoxa13: HFGS and Guttmacher syndromes 10 II. The Homeodomain 12 A. Homeodomain structure 12 B. DNA binding 14 Ill. Limb development 16 A. Patterning of the limb axes 16 B. Digit formation 20 C. lnterdigital programmed cell death 21 IV. BMPs and limb development 23 A. BMP signaling in the limb 23 B. BMP target genes 27 V. Hoxa13 and embryonic development 30 A. The Hoxa13-GFP mouse model 30 B. Hoxa13 mutant phenotypes 34 C. HOXA 13 homeodomain 35 D. HOXA 13 protein-protein interactions 36 E. HOXA 13 target genes 37 VI. Hypothesis and Rationale 39 CHAPTER 2: HOXA13 regulates Bmp2 and Bmp7 40 I. Abstract 42 II. Introduction 43 Ill. Results 46 IV. Discussion 69 v. Materials and Methods 75 VI. Acknowledgements 83 11 CHAPTER 3: Quantitative analysis of HOXA13 function 84 HOXA 13 regulation of Sostdc1 I. -
The Contributions of George Beadle and Edward Tatum
| PERSPECTIVES Biochemical Genetics and Molecular Biology: The Contributions of George Beadle and Edward Tatum Bernard S. Strauss1 Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637 KEYWORDS George Beadle; Edward Tatum; Boris Ephrussi; gene action; history It will concern us particularly to take note of those cases in Genetics in the Early 1940s which men not only solved a problem but had to alter their mentality in the process, or at least discovered afterwards By the end of the 1930s, geneticists had developed a sophis- that the solution involved a change in their mental approach ticated, self-contained science. In particular, they were able (Butterfield 1962). to predict the patterns of inheritance of a variety of charac- teristics, most morphological in nature, in a variety of or- EVENTY-FIVE years ago, George Beadle and Edward ganisms although the favorites at the time were clearly Tatum published their method for producing nutritional S Drosophila andcorn(Zea mays). These characteristics were mutants in Neurospora crassa. Their study signaled the start of determined by mysterious entities known as “genes,” known a new era in experimental biology, but its significance is to be located at particular positions on the chromosomes. generally misunderstood today. The importance of the work Furthermore, a variety of peculiar patterns of inheritance is usually summarized as providing support for the “one gene– could be accounted for by alteration in chromosome struc- one enzyme” hypothesis, but its major value actually lay both ture and number with predictions as to inheritance pattern in providing a general methodology for the investigation of being quantitative and statistical. -
Genes, Genomes and Genetic Analysis
© Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION UNIT 1 © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FORDefining SALE OR DISTRIBUTION and WorkingNOT FOR SALE OR DISTRIBUTION with Genes © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION Chapter 1 Genes, Genomes, and Genetic Analysis Chapter 2 DNA Structure and Genetic Variation © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Molekuul/Science Photo Library/Getty Images. © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC. NOT FOR SALE OR DISTRIBUTION 9781284136609_CH01_Hartl.indd 1 08/11/17 8:50 am © Jones & Bartlett Learning, LLC -
Barbara Mcclintock
Barbara McClintock Lee B. Kass and Paul Chomet Abstract Barbara McClintock, pioneering plant geneticist and winner of the Nobel Prize in Physiology or Medicine in 1983, is best known for her discovery of transposable genetic elements in corn. This chapter provides an overview of many of her key findings, some of which have been outlined and described elsewhere. We also provide a new look at McClintock’s early contributions, based on our readings of her primary publications and documents found in archives. We expect the reader will gain insight and appreciation for Barbara McClintock’s unique perspective, elegant experiments and unprecedented scientific achievements. 1 Introduction This chapter is focused on the scientific contributions of Barbara McClintock, pioneering plant geneticist and winner of the Nobel Prize in Physiology or Medicine in 1983 for her discovery of transposable genetic elements in corn. Her enlightening experiments and discoveries have been outlined and described in a number of papers and books, so it is not the aim of this report to detail each step in her scientific career and personal life but rather highlight many of her key findings, then refer the reader to the original reports and more detailed reviews. We hope the reader will gain insight and appreciation for Barbara McClintock’s unique perspective, elegant experiments and unprecedented scientific achievements. Barbara McClintock (1902–1992) was born in Hartford Connecticut and raised in Brooklyn, New York (Keller 1983). She received her undergraduate and graduate education at the New York State College of Agriculture at Cornell University. In 1923, McClintock was awarded the B.S. -
Pullman Company Archives
PULLMAN COMPANY ARCHIVES THE NEWBERRY LIBRARY Guide to the Pullman Company Archives by Martha T. Briggs and Cynthia H. Peters Funded in Part by a Grant from the National Endowment for the Humanities Chicago The Newberry Library 1995 ISBN 0-911028-55-2 TABLE OF CONTENTS Introduction ............................................. v - xii ... Access Statement ............................................ xiii Record Group Structure ..................................... xiv-xx Record Group No . 01 President .............................................. 1 - 42 Subgroup No . 01 Office of the President ...................... 2 - 34 Subgroup No . 02 Office of the Vice President .................. 35 - 39 Subgroup No . 03 Personal Papers ......................... 40 - 42 Record Group No . 02 Secretary and Treasurer ........................................ 43 - 153 Subgroup No . 01 Office of the Secretary and Treasurer ............ 44 - 151 Subgroup No . 02 Personal Papers ........................... 152 - 153 Record Group No . 03 Office of Finance and Accounts .................................. 155 - 197 Subgroup No . 01 Vice President and Comptroller . 156 - 158 Subgroup No. 02 General Auditor ............................ 159 - 191 Subgroup No . 03 Auditor of Disbursements ........................ 192 Subgroup No . 04 Auditor of Receipts ......................... 193 - 197 Record Group No . 04 Law Department ........................................ 199 - 237 Subgroup No . 01 General Counsel .......................... 200 - 225 Subgroup No . 02 -
A Giant of Genetics Cornell University As a Graduate Student to Work on the Cytogenetics of George Beadle, an Uncommon Maize
BOOK REVIEW farm after obtaining his baccalaureate at Nebraska Ag, he went to A giant of genetics Cornell University as a graduate student to work on the cytogenetics of George Beadle, An Uncommon maize. On receiving his Ph.D. from Cornell in 1931, Beadle was awarded a National Research Council fellowship to do postdoctoral work in T. H. Farmer: The Emergence of Genetics th Morgan’s Division of Biology at Caltech, where the fruit fly, Drosophila, in the 20 Century was then being developed as the premier experimental object of van- By Paul Berg & Maxine Singer guard genetics. On encountering Boris Ephrussi—a visiting geneticist from Paris— Cold Spring Harbor Laboratory Press, at Caltech, Beadle began his work on the mechanism of gene action. 2003 383 pp. hardcover, $35, He and Ephrussi studied certain mutants of Drosophila whose eye ISBN 0-87969-688-5 color differed in various ways from the red hue characteristic of the wild-type fly. They inferred from these results that the embryonic Reviewed by Gunther S Stent development of animals consists of a series of chemical reactions, each step of which is catalyzed by a specific enzyme, whose formation is, in http://www.nature.com/naturegenetics turn, controlled by a specific gene. This inference provided the germ for Beadle’s one-gene-one-enzyme doctrine. To Beadle and Ephrussi’s “Isaac Newton’s famous phrase reminds us that major advances in disappointment, however, a group of German biochemists beat them science are made ‘on the shoulders of giants’. Too often, however, the to the identification of the actual chemical intermediates in the ‘giants’ in our field are unknown to many colleagues and biosynthesis of the Drosophila eye color pigments. -
The Street Railway Journal
Vol. X No. 3. The Trolley Cars in Bremen. The length of the line is 6.21 miles, of which 4 miles is laid with single track, and 2.21 miles with double track. Among the progressive communities of Northern The entire system consists of two lines, one running from Germany, the flourishing city of Bremen, with its white the Burgerpark to Freihafen, and the other from Horn to houses and well kept streets, was one of the earliest to the Hohen Thor, the lines from the railroad station to the adopt electric traction. The steady horse car had for corner of the Langen and Kaisers Strassen being common many years carried the staid burgers of the old Hanse to both systems. City by the Weser, along its narrow, picturesque streets, The power station for the generation and supply of crowded with historical memories, when to be a city of the current is located on the Schlachthof, near to the line to principal Hanseatic League meant almost to be a repub- the Burgerpark. It is a brick building constructed in lic. But the expansion of the town by the growing trade three parts, one containing the engine and generator of the world, a goodly part of which has chosen Bremen room, the second the boilers, and the third and smallest FIG. 1. — ELECTRIC CARS PASSING THE MARKET PLACE—BREMEN, GERMANY. as its inlet to the vast markets of the North German ter- the coal bins. It covers 4,777 square feet of ground ritories, determined a beneficial change in transportation space. -
Joshua Lederberg – in Memoriam
ARTICLE-IN-A-BOX Joshua Lederberg – In Memoriam The foundations of the young science of molecular biology were laid towards the middle of the last century, primarily resting on a series of outstanding discoveries where microorganisms played a significant role. The exploitation of bacteria to address fundamental questions related to the nature of genes and how they function unleashed a steady stream of path-breaking discoveries during the 1940s and 50s. This was rather ironic since the term bacterial genetics would have been considered an oxymoron only a few years ago as the idea of bacteria possessing genes was alien to most geneticists who were busy working with plants, flies, and fungi. Joshua Lederberg, who passed away in February 2008, was one of the undisputed leaders of this molecular biology revolution. Lederberg’s work led to the discovery of two forms of genetic exchange in bacteria – conjugation and transduction. These discoveries had an enormous impact in opening up the genetic analysis of bacteria that resulted in other major breakthroughs such as the elucidation of the mechanism of gene regulation. For his contribu- tions to microbial genetics, Lederberg shared the 1958 Nobel Prize for Physiology or Medicine with Edward Tatum and George Beadle. Lederberg’s contributions however did not confine only to the field of bacterial genetics. He was keenly interested in exotic areas such as artificial intelligence, extra-terrestrial life (exobiology) and space exploration and made significant contributions to these fields too. He also championed the cause of disarmament and elimination of biological weapons. In a sense, he was also a science journalist as he regularly contributed articles dealing with science and public issues in the Washington Post and The Chronicle.