Terpenes As Starting Material in the Synthesis of Natural Products
Total Page：16
File Type：pdf, Size：1020Kb
ACADEMY OF SCIENCES OF MOLDOVA INSTITUTE OF CHEMISTRY STATE UNIVERSITY OF MOLDOVA INSTITUTE OF APPLIED PHYSICS INSTITUTE OF ELECTRONIC ENGINEERING AND NANOTECHNOLOGIES CHEMICAL SOCIETY OF MOLDOVA The XVIII-th International Conference "Physical Methods in Coordination and Supramolecular Chemistry" (Dedicated to the memory of the professor Constantin Turta and professor Mihail Revenco) BOOK OF ABSTRACTS October 8-9, 2015 Chişinău, MOLDOVA LIST OF SPONSORS SUPREME COUNCIL FOR SCIENCE AND TECHNOLOGICAL DEVELOPMENT, ACADEMY OF SCIENCES OF MOLDOVA INSTITUTE OF CHEMISTRY, ACADEMY OF SCIENCES OF MOLDOVA STATE UNIVERSITY OF MOLDOVA NITECH S.R.L. STATE AGENCY ON INTELLECTUAL PROPERTY OF THE REPUBLIC OF MOLDOVA REDOX LAB SUPPLIES S.R.L. VALIEXCHIMP S.R.L. INTERNATIONAL ADVISORY BOARD Gheorghe Duca (Moldova) - Chairman Sebastien Floquet (France) Sergey Aldoshin (Russia) Christoph Janiak (Germany) Serghey Andronati (Ukraine) Janusz Lipkowski (Poland) Marius Andruh (Romania) Ionel Mangalagiu (Romania) Vladimir Arion (Austria) Marius Reglier (France) Juan Bartolome (Spain) Donald Poirier (Canada) Andrew Benniston (UK) Annie Powell (Germany) Isaak Bersuker (USA) Bogdan Simionescu (Romania) Rodolphe Clerac (France) Grigore Timco (UK) Boris Tsukerblat (Israel) ORGANIZING COMMITTEE Gheorghe Duca – Chairman Ion Geru Aurelian Gulea – Co-chairman Viorica Gladchi Vasile Lozan - Co-chairman Natalia Gorincioi Vadim Druta – Secretary Victor Kravtsov Aculina Aricu Tudor Lupashcu Polina Bourosh Mihai Macovei Ion Bulhac Igor Povar Ion Bulimestru Anatolie Sidorenko Diana Dragancea Constantin Turta PROGRAM COMMITTEE Vasile Lozan – Chairman Boris Pușcașu Victor Kravtsov - Co-chairman Piotr Petrenko Vadim Druta – Secretary Sergiu Shova Svetlana Baca Marina Fonari Maria Cocu Dumitru Sirbu Eduard Coropceanu Diana Șepeli Olesea Cuzan Tatiana Straistari Constantin Indricean Victor Tsapkov Ana Lazarescu Irina Voda Silvia Melnic L1 TRENDS OF COORDINATION CHEMISTRY DEVELOPMENT IN THE REPUBLIC OF MOLDOVA Gheorghe Duca Academy of Sciences of Moldova, 1 Stefan cel Mare Ave., MD 2001, Chisinau, Republic of Moldova This report emphasizes the most relevant achievements obtained in the coordination chemistry in the Republic of Moldova. The main results of scientific investigations of the Moldovan research centres are presented, as well as the most important successes attained in various areas of inorganic, coordination, bioinorganic, and quantum chemistry. Historically, chemical science in Moldova started in the 1940s with investigations in the area of coordination compounds of transition metals, in particular, of dioximates of d-metals, the study of the structure and properties of this class of compounds using the newest, at that time, physical methods of research. Later, the range of scientific themes significantly expanded, comprising template processes, topochemical synthesis, obtaining of mono- and polynuclear coordination compounds, including those with macrocyclic and chelating ligands; the synthesis of biologically active complexes,development of the theory of electronic and vibronic structure of compounds with mixed valence, etc., optimization of quantum-chemical research techniques, as well as of methods of the molecular design of biologically active systems, with the focus on their action mechanism. In 2006 the Centre of “Physical Chemistry and Nanocomposites” was created at the Institute of Chemistry, hence the research with the view of obtaining nanoparticles has started. The aims of the Centre are to investigate the formation of nanoparticles and to elaborate the methods of their production required in nanoelecronics; to elaborate advanced technologies, to produce new substances necessary for the national economy for the development of alternative energy sources, of new medicinal preparations, applications in agriculture, solving the issues of environmental protection. During the past years, Moldovan scientists intensively investigated mono- and polynuclear coordination compounds of metals (transition and s-type) as photo-catalysts, MOFs for gas storage and as nanostructurated materials for water photolysis. Other current directions of investigations are: obtaining inhibitors of cancer cells proliferation; preparing materials with useful magnetic properties, good for various applications including agriculture (as plant growth stimulators). The report will reflect also the contribution of the famous Moldovan inorganic chemists - professors Constantin Turta and Mihail Revenco, into the developement of the coordination and supramolecular chemistry in the Republic of Moldova and the main scientific achievements of the both. 1 L2 POLYMERS IN SUPRAMOLECULAR ASSEMBLIES FOR BIO-RELATED APPLICATIONS Bogdan C. Simionescu "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy & Department of Natural and Synthetic Polymers, "Gh. Asachi" Technical University of Iasi, Iasi, Romania Last decades, a pronounced need for new materials for biomedical application, able to provide more efficient treatments and to insure minimization of the side effects, to increase patient compliance and satisfaction is evident. At the same time, advances in polymer science have led to the development of several novel systems designed for drug/gene delivery and tissue engineering, areas with pivotal role for both research/academic community and industry, generating new niche markets. In this respect, recent years have witnessed an increased interest in the rational design of complex polymeric structures. The main objectives are related to the development of tailored polymer materials, engineered to exert distinct biological functions, implying multifunctionality as well as appropriate form/architectural features, giving rise to specificity and high responsiveness. To gain further clinical importance the new materials must provide not only high physicochemical and biological performances but also processing ability. These demands – and especially the last one – often imply combination of natural and synthetic polymers (blends, block/graft copolymers, bioconjugates, interpenetrating networks, etc.), while improved performances may be mainly achieved by composite materials (inorganic/organic, biocomposites). The targeted application site or cargo may require specific material category (biodegradable, bioresorbable), dimension scale (micro/nano size) and topographic characteristics. Some of the existing essential obstacles and limitations may be surpassed by combining systems and approaches from apparently different application domains. Thus, controlled drug delivery and its application in tissue engineering for tissue growth support and stimulation attracted much attention over the last decade, while combination of gene therapy and tissue engineering within a single system resulting in a powerful synergism of treatment options for regenerative medicine (scaffold mediated gene therapy) seems to be the favored alternative for tissue healing. The presentation summarizes the history and challenges in the discussed domains, pointing on polymers as a possible solution to specific challenges, and outlines the current state of the art, focusing on the newest strategies to improve systems effectiveness and responsiveness (design keys, preparative approaches). Expected future directions are underlined. Acknowledgement. This work was financially supported by the Romanian National Authority for Scientific Research, CNCS - UEFISCDI, project PN-II-ID-PCCE-2011-2-0028. 2 L3 POLYFUNCTIONAL NITROSYL IRON COMPLEXES AS A NEW CLASS OF NO DONORS FOR MEDICINE, WHICH HAVE UNUSUAL “ENTANGLED” MAGNETIC AND ELECTRONIC PROPERTIES S.M. Aldoshin1, N.A. Sanina1, A.V. Palii2 1Institute of Problems of Chemical Physics, 1, Institutskii Av., 142432 Chernogolovka, Moscow Region, Russia 2Institute of Applied Physics, Academy of Sciences of Moldova The method of synthesis has been developed and dinitrosyl iron complexes of a new class (DNIC) have been obtained, which contain functional sulfur-containing ligands and are mimetics of the active sites of nitrosyl non-heme proteins. The structure of cationic, neutral and anionic forms of paramagnetic mononuclear, diamagnetic binuclear of µ-S type and paramagnetic of µ- S-CN type nitrosyl complexes has been studied. Based on precision X-ray data and quantum- - chemical calculations, specific features of the electronic structure of the basic (NO)2Fe unit of these complexes have been studied, as well as the influence of the ligand surrounding on NO donating properties and mechanism of decomposition of the complexes in various solvents at different pH values of the solutions. The obtained results open possibilities for the development of promising medicines on their base, i.e., NO donors for the therapy of socially relevant diseases [1]. In some paramagnetic mononuclear cationic DNIC absolutely unusual magnetic properties have been detected, which cannot be explained in the frame of usual spin model The performed calculation shows a considerable contribution of unquenched orbital moment of the NO group in the magnetic properties of these complexes, which is also responsible for the residual magnetism of diamagnetic anionic DNIC of µ-S type. Specific features of the crystalline and molecular structure of DNIC, which are responsible for orbital paramagnetism have been studied. Bi-nuclei paramagnetic DNIC of μ-S-C-N type having a Heisenberg dimer structure and characterized by antiferromagnetic intramolecular exchange appeared to be promising compounds, which at low temperature