Date: March 9,20171:07PM Client Code:GLCM/LCZ/0228 Product: Entresto Client: Novartis Path: PrePress:Novartis:LCZ696:10709397:10709397_ESC_FinalPrgrmAd_M1 Proof: M1 Job #:10709397 10709397_ESC_FinalPrgrmAd_M1.indd 1 4C * The complementarycardiovascularbenefits ofENTRESTO inpatientswithHFrEF areattributedtotheenhancementofpeptidesthatdegraded ARR=absolute riskreduction;CV=cardiovascular;HF=heartfailure;HFrEF=heart failurewithreducedejectionfraction. ‡ † onthe Kansas measuredthechangefrombaselineto8monthsinclinicalsummary score Secondary endpointthat CityCardiomyopathy Questionnaire (KCCQ). Primary endpoint. enalapril inheartfailure. NEnglJMed European MedicinesAgency, 2016.http://www.ema.europa.eu. 4.McMurrayJJ, Packer M,DesaiAS, etal.Angiotensin–neprilysininhibitionversus pathophysiology ofheartfailure:frommolecular basis to treatment.ClinSci.2016;130(2):57-77.3.ENTRESTO SummaryofProduct Characteristics. heart failure.AmHealthDrugBenefits. 2015;8(6):330-334. angiotensinreceptorneprilysininhibitorFDAReferences: approvedfor patientswith Entresto(sacubitril/valsartan):First-in-class 1.Fala L. Please seeSummaryofProduct CharacteristicsatBoothB30. by neprilysin,suchasnatriureticpeptides(NP),sacubitrilandthesimultaneousinhibitionofdeleteriouseffects angiotensin IIbyvalsartan. This medicinalproductissubjecttoadditionalmonitoring. Healthcare professionalsareasked toreportanysuspectedadversereactions. C VTETEHAT HEART ETHE IVAT ACT C VTELIFE IVAT ACT . 2014;371(11):993-1004. Note: Bleed: 160mmwx220h Trim: 150mmwx210h Live: 130mmwx190h Add’l Info: Escape, HelveticaNeueLT Std,MinionPro Fonts: NewsGothCnBT, TheGreat Colors: 4C Releasing as:PDFX-1a PREPARED BYFCB 2. Volpe M,Carnovali MastromarinoV. Thenatriureticpeptidessystemin the B:160 mm T:150 mm S:130 mm longer andoutofthehospital symptomatic HFrEF patientsliving Quality ofLife IT’S TIMEFORENTRESTO When youseesymptoms, Significant improvementsinQuality • ENTRESTO • ENTRESTO © 2017Novartis PharmaAG, CH-4002 BaselMarch2017 GLCM/LCZ/0228 ARR=4.7%) hospitalisation vsenalapril(P 20% reducedrisk ( symptoms andphysicallimitations reduced deteriorationofheartfailure of Lifevsenalapril,asmeasuredby P =0.001) world ofaHFrEF patient. Join us and discover the Join usanddiscoverthe ESC FinalProgram Ad ® ® 4‡ keeps your keeps your helps improve helpsimprove Digital Artist:CL QC: L.Powell Producer: PatriciaChungx3162 AE: Lyn Settlemyre x3906 AD:Adam Nemser Production: Barbara.Grantx3946 FR Spellcheck: M1 Spellcheck:D.Fitzgerald 3† 1,2 4 of CVdeathorfirst HF * <0.0001; 3 3/9/17 1:27PM 3
Heart Failure mm 2017S:190 • PARIS T:210 mm T:210 B:220 mm B:220 w.sadoogHA#heartfailure2017 www.escardio.org/HFA P 29 April-2 May Heart Failure:Heart rendez-vous withthefuture France aris Heart 2017 Congress Failure organised by theHeart Association oftheESC Failure and 4 on Acute Heart Failureon Acute Heart Final Programme Final th World Congress World Harnessing a revolution in biology for human health®
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© 2016 Alnylam Pharmaceuticals, Inc. Welcome Address
Dear friends and colleagues,
On behalf of the board of the Heart Failure Association and the organising committee, it is our great pleasure to welcome you to our annual congress Heart Failure 2017 & World Congress on Acute Heart Failure.
“Rendez-vous with the future” is the theme of this year’s meeting of the world`s leading heart failure association. Our congress is an essential platform for scientific exchange and networking with invaluable contributions of experts from around the world.
The scientific programme will provide the latest updates from the field of heart failure and recommendations for implementation in daily practice. Original scientific research is the core of the congress and we are proud to report the submission of a record-breaking 2 197 abstracts & clinical cases.
In addition, we are honoured that our esteemed colleagues Prof. Michel Komajda and Prof. Faiez Zannad will be awarded HFA Lifetime Achievement Awards and present the Eugene Braunwald and Philip Poole-Wilson Lectures during the Inaugural session.
On Sunday, join us for the HoT Walk organised by the Heart Failure specialist of Tomorrow to raise the public awareness on heart failure.
We look forward to welcoming you to beautiful Paris - the “City of Lights”.
Alexandre Mebazaa Frank Ruschitzka Heart Failure 2017 Chairperson HFA President
1 Organising Committees
BOARD MEMBERS OF THE HFA
Frank Ruschitzka HFA President Petar Seferovic President Elect Gerasimos Filippatos Immediate Past President Andrew Coats Treasurer Mitja Lainscak National HF Societies coordinator Rudolf De Boer Chairman of the Basic Science section Massimo Piepoli Chairman of the Clinical Science section Marisa Crespo-Leiro Secretary
Clinical Section Basic Science Section Ex-officio Yuri Lopatin Johann Bauersachs Marco Metra Jelena Celutkiene Johannes Backs Alexandre Mebazaa Veli Pekka Harjola Alexander Lyon Stefan Anker Ewa Jankowska Stephane Heymans Lars Lund Piotr Ponikowski Christian Mueller Isabel Bardinet Giuseppe Rosano Loreena Hill Sui Generis Davor Milicic Theresa Mcdonagh Jillian Riley Arno Hoes
Local organising committee
Alexandre Mebazaa - Heart Failure 2017 Chairperson
Thibaud Damy Patrick Rossignol Patrick Jourdain Michel Komajda François Roubille Florence Beauvais Alain Cohen Solal Véronique Alibert Richard Isnard Jean-Yves Le Heuzey Véronique Thore Frédéric Mouquet Faiez Zannad Damien Logeart Stéphane Germain Pascal De Groote Jean-Noël Trochu Yves Juillère Michel Galinier Dominique Guedj Claire Bouleti Laribi Saïd Alain Ducardonnet Etienne Gayat
2 Me bership • Regular • Silver • Gold • Fellows VISION OF • Heart Failure Specialists of Tomorrow THE HFA • Committees and Study Groups
Ad ocacy
• National Heart Failure Societies • Heart Failure Awareness Day • Patient website • HFA Summit
Research • European Journal Congresses of Heart Failure E ents • ESC Heart Failure • Heart Failure congresses • Registries • Scientific Workshops • Winter Meeting • Clinical Trialists Summer School • Joint sessions at international congresses TO RE UCE THE BUR EN OF Education CAR IOVASCULAR ISEASE IN EURO E
• E-learning • Webinars • Heart Failure Specialist Curriculum Grants • Heart Failure Certification • Nurse Research Fellowship • Postgraduate Course in Heart Failure • Congress grants & awards • Guidelines • Patient Care Workshop
3 HEART FAILURE ASSOCIATION OF THE ESC Working together for the future of heart failure
ONLY DURING THE CONGRESS GET 20% OFF YOUR ANNUAL MEMBERSHIP* Make the most of your congress Relive the congress with exclusive access to slides and webcasts • Meet your peers in the HFA Members’ Lounge • Benefit from exclusive discount on Heart Failure Certification and educational courses • Find your colleagues online with the HFA members network • Join our Fellow community and get recognition from your peers
SPECIAL PRICE: APPLY FOR MEMBERSHIP
* * SILVER 77€ GOLD 115€
*Conditions apply: discount exclusively available during the duration of the congress. For more information come to the HFA stand B20.
I’M AN HFA MEMBER. WE ARE THE ESC
BOOTH B20 www.escardio.org/HFA Table of contents
Congress Information...... 8
Highlights at Heart Failure 2017...... 10
Sessions by Topic...... 11
Sessions by Day...... 17
Scientific Programme Saturday 29 April
Scientific sessions...... 22
Poster session 1...... 42 Sunday 30 April
Hands-On tutorials...... 72
Scientific sessions...... 75
Poster session 2...... 98 Monday 1st May
Hands-On tutorials...... 128
Scientific sessions...... 131
Poster session 3...... 154 Tuesday 2 May
Scientific sessions...... 184
Poster session 4...... 190
Index of Chairpersons & Judges...... 206
Index of Speakers...... 208
Index of Authors...... 211
5 INAUGURAL SESSION Saturday 17:40 - 18:45 Room HUGO
Chairpersons F. Ruschitzka, A. Mebazaa, P. Seferovic
Welcome from the President of the HFA F. Ruschitzka
Welcome to Heart Failure 2017 & World Congress on Acute Heart Failure A. Mebazaa
Welcome from the President of the ESC J. Bax
Introduction of Faiez Zannad G. Filippatos
HFA Philip Poole Wilson lecture: Mineralocorticoid receptor antagonists. Navigating the landscape, from trials to clinical practice and to reverse translational science. F. Zannad
Introduction of Michel Komajda E. Braunwald
HFA Eugene Braunwald lecture: Heart failure and diabetes mellitus: “les liaisons dangereuses” M. Komajda
New elected Fellows of the HFA T.A. Mcdonagh
Winners of the Heart Failure Awareness Days M. Lainscak Building Floor Plan
LEVEL 3
ZOLA
CATERING
MONET Virtual Case area POSTERS
To Hands-on Tutorials LEVEL 2 CATERING PIAF MATISSE