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Colorectal Cancer SCHWEIZER Dezember 2013 04 Dezember 2013 04 Erscheint vierteljährlich Jahrgang 33 DU CANCER SCHWEIZER KREBSBULLETIN BULLETIN SUISSE Via Ernährung das Darmkrebsrisiko senken, S. 337 Schwerpunkt: Colorectal Cancer BAND 33, DEZEMBER 2013, AUFLAGE 4200 INHALTSVERZEICHNIS Editorial KLS Krebsliga Schweiz 334 Würdigung herausragender Verdienste für krebsbetroffene 281-282 After and before WOF Menschen F. Cavalli K. Bodenmüller Pressespiegel 335 Brustzentrum des Kantonsspitals Baden mit Qualitätslabel ausgezeichnet 285-290 Cancer in the media K. Bodenmüller Schwerpunktthema 336 Brustkrebs: Eine Anziehpuppe erleichtert Gespräche Colorectal cancer zwischen Eltern und Kindern S. Jenny 293-295 Colorectal cancer: much has been done, but there is still a long way to go 337 Via Ernährung das Darmkrebsrisiko senken P. Saletti K. Zuk 296-298 Kolonkarzinomscreening 2013: Sind wir einen Schritt 338 Un honneur qui récompense de grands mérites en faveur weiter? des personnes atteintes du cancer U.A. Marbet, P. Bauerfeind K. Bodenmüller 339 Remise du label de qualité au Centre du sein de l’Hôpital 299 Kolorektales Karzinom in der Schweiz cantonal de Baden M. Montemurro K. Bodenmüller 300-301 Kassenpflicht für Kolonkarzinom-Früherkennung 340 Nouvelle formation continue en psycho-oncologie K. Haldemann Interview avec Dr. Friedrich Stiefel V. Moser Celio 302-306 Epidémiologie et prise en charge du cancer colorectal: une étude de population en Valais 342 Fort- und Weiterbildungen der Krebsliga Schweiz I. Konzelmann, S. Anchisi, V. Bettschart, J.-L. Bulliard, Formation continue de la Ligue suisse contre le cancer A. Chiolero OPS Onkologiepflege Schweiz Originalartikel 344-346 Hautveränderungen bei antitumoralen Therapien S. Wiedmer 309-313 Neglected symptoms in palliative cancer care T. Fusi, P. Sanna SGMO Schweizerische Gesellschaft 315-318 Multidisciplinary management of urogenital für Medizinische Onkologie tumours at the Ente Ospedaliero Cantonale 349 Elektronisches Patientendossier und Behandlungspfade E. Roggero and the EOC Multisciplinary Urogential J. Nadig, C. Bosshard Tumour Board Cooperative Groups SAKK Schweizerische Arbeitsgemeinschaft für 350-352 Fruitful collaborations to improve knowledge and Klinische Krebsforschung treatment outcome of primary CNS Lymphoma: The International PCNSL Collaborative Group (IPCG) 320-321 SAKK News and the European PCNSL Collaborative Group (EPCG) D. Ammann B. Kasenda, A. J. Ferreri, E. Zucca SPOG Schweizerische Pädiatrische 353 International Breast Cancer Study Group IBCSG R. Maibach Onkologiegruppe 323-326 Can pharmacogenetics and pharmacokinetics of busulfan 354-355 The European Thoracic Oncology Platform (ETOP) be used to individualize treatment for children undergoing S. Peters Hematopietic stem cell transplantation? A. K. Tyagi, C. R. Uppugunduri, P. Huezo-Diaz, M. Ansari Der seltene Fall 357-360 Kleinzelliges Karzinom des Rektums und cerebrovaskulärer Insult: eine therapeutische NICER National Institute for Cancer Epidemiology Herausforderung and Registration C. Leitner, R. v. Moos, G. Gadient, T. Freyholdt, R. Cathomas 328-332 Trends in Pancreatic Cancer Survival in Switzerland M. Montemurro, M. Lorez and the NICER Working Group 362 Agenda Schwerpunktthema Ausgabe Nr. 1-2014: Personalized Medicine Nächste Eingabetermine: Nr. 1/2014: 14. Januar – Nr. 2/2014: 15. April – Nr. 3/2014: 15. Juli – Nr. 4/2014: 18. September Schweizer Krebsbulletin . Nr. 4/2013 AFINITOR® – strong in three indications EDITORIAL 1-3 Oral mTOR-inhibitor with anti-tumour efficacy in mRCC, pNET and aBC After and In October 2012 the European School of Oncology (ESO) organised, in occasion of its 30th anniversary, a World Oncology Forum (WOF) in Lugano, devoted before WOF to the question «Are we winning the war against cancer?». We have already published in one of the previous issues of our bulletin (1) some of the most sig- nificant material which was produced by the gathering. In particular there were 100 experts (including almost 20 scientific journalists) from five continents, who reached an agreement about the Appeal: «Stop Cancer Now!», which was Now then published on February 4th, 2013 (Cancer World Day) in the corresponding languages in five leading global newspapers: International Herald Tribune, Le approved Monde, El Pais, La Repubblica, Neue Zürcher Zeitung. for HR+/HER2-advanced breast cancer During the same week the Appeal, together with an editorial and a commentary (2,3,4), was published in the Lancet. If one tries to summarise very briefly the outcome of the WOF 2012, particularly in relation to the original question, one might say that while we most probably are on the right track to win the war against cancer from a scientific point of view, we might be about to lose it from a global point of view if one considers the forecast for 2030, when we could have as many as 13 million cancer deaths, while 2008 they were 7.6 million. This is mainly due to the very rapid increase of the number of cancer cases in the developing world, where prevention is almost inexistent, early diagnosis is First choice in 2nd-line mRCC 1,6 -11 very difficult and there is a tremendous lack of therapeutic resources (5). This fact has been appreciated now eventually also at the political level and is one of Recommended choice in advanced pNet 12 the reasons why in September 2011 the United Nations (UN) held a meeting of Heads of State about Non-Communicable Diseases (NCDs). This was only the Breakthrough in HR + advanced breast cancer 13, 14 2nd of such meetings organised by the UN on a health-related issue. The first, in 2011, was on HIV and on AIDS. Although NCDs were ignored during the framing of the Millennium Devel- opment goals in 2000, their growing contribution to preventable deaths and disability across the globe has compelled policy makers to pay attention to this situation. After this meeting, the WHO has called for a 25% reduction by 2025 Abbreviations: aBC: advanced breast cancer. In postmenopausal women with HR+/HER2-negative advanced breast cancer in combination with exemestane; mRCC: metastatic renal cell carcinoma. International Guidelines (ESMO1, NCCN2, EAU3 & EORTC4) consistently recommend in mortality from NCDs among persons between 30 and 75 years of age, adopt- AFINITOR® after failure of tyrosine-kinase inhibitors (TKI). Swissmedic indication: after sunitinib or sorafenib; pNET: pancreatic neuroendocrine tumour 1. Motzer RJ et al. Effi cacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008;372:449-456. 2. Yao JC et al. Everolimus for Advanced Pancreatic Neuroendocrine Tumors. New Engl J Med ing the slogan «25 by 25». The WHO is currently formulating its policy to 2011;364:514-523. 3. Baselga J et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med. 2012;366:520-529. 4. Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006;124:471-484. 5. Humar R et al. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J. 2006;20:1573. 6. Escudier B et al. Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and achieve this ambitious goal. Alas it seems that cancer is coming a bit lost in the follow-up. Annals of Oncology 23 (Supplement 7): vii65-vii71, 2012. 7. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. Kidney Cancer. V.2.2012. 8. Ljungberg B et al. EAU guidelines on renal cell carcinoma: the 2010 update. Eur Urol 2010;58:398-406. 9. de Reijke TM et al. EORTC-GU group expert opinion on metastatic renal cell cancer. European Journal of Cancer 2009;45: 765-773. 10. Motzer RJ et al. Phase 3 trial of everolimus for metastatic renal cell carcinoma: fi nal results and analysis of realm of NCDs notwithstanding the efforts of UICC and also ESMO to have a prognostic factors. Cancer 2010;116:4256-4265. 11. For more information please see www.swissmedicinfo.ch. 12. Pavel M et al. ENETS Consensus Guidelines for the Management of Patients with Liver and Other Distant Metastases from Neuroendocrine Neoplasms of Foregut, Midgut, Hindgut, and Unknown Primary. Neuroendocrinology 2012;95:157-176. 13. Piccart M et al. Final Progression-Free Survival Analysis of BOLERO-2: A Phase III Trial of Everolimus for Postmenopausal Women With Advanced Breast Cancer. SABC 2012, clear cut cancer-policy devised. At the time being therefore cancer treatment is San Antonio/USA; Poster P6-04-02. 14. Gnant M. The Role of Mammalian Target of Rapamycin (mTOR) Inhibition in the Treatment of Advanced Breast Cancer. Curr Oncol Rep 2013;15:14-23. Afi nitor® (Everolimus) C: Tablets containing 5 mg or 10 mg everolimus. I: In combination with exemestane for the treatment of postmenopausal women with advanced, hormon receptor-positive, HER 2-negative breast cancer after treatment failure with letrozole almost forgotten or it appears just in some small notes. In my opinion this is a or anastrozole . Treatment of patients with - advanced, progressive, well- or moderately-differentiated neuroendocrine tumors of pancreatic origin - advanced renal cell carcinoma after failure of a therapy with sunitinib or sorafenib* D: 10 mg in a once-a-day dosage, always at the same time of day, administered orally, with or without food. Undesired effects may require temporary dose reduction and/or discontinuation of the treatment. Not recommended for paediatric cancer patients. For those suffering from moderately impaired wrong approach
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