Where Are You Talking About? Advances and Challenges of Geographic Analysis of Text with Application to Disease Monitoring

Total Page:16

File Type:pdf, Size:1020Kb

Where Are You Talking About? Advances and Challenges of Geographic Analysis of Text with Application to Disease Monitoring Where are you talking about? Advances and Challenges of Geographic Analysis of Text with Application to Disease Monitoring Milan Gritta Supervisor: Dr Nigel Collier Department of Theoretical and Applied Linguistics University of Cambridge This dissertation is submitted for the degree of Doctor of Philosophy Fitzwilliam College February 2019 Declaration This dissertation is the result of my own work and includes nothing which is the outcome of work done in collaboration except as declared in the Preface and specified in the text. Itis not substantially the same as any that I have submitted, or, is being concurrently submitted for a degree or diploma or other qualification at the University of Cambridge or any other University or similar institution except as declared in the Preface and specified in the text. I further state that no substantial part of my dissertation has already been submitted, or, is being concurrently submitted for any such degree, diploma or other qualification at the University of Cambridge or any other University or similar institution except as declared in the Preface and specified in the text. It does not exceed the prescribed word limitforthe relevant Degree Committee. Milan Gritta February 2019 Where are you talking about? Advances and Challenges of Geographic Analysis of Text with Application to Disease Monitoring Abstract - Milan Gritta The Natural Language Processing task we focus on in this thesis is Geoparsing. Geoparsing ​ ​ is the process of extraction and grounding of toponyms (place names). Consider this sentence: "The victims of the Spanish earthquake off the coast of Malaga were of American ​ ​ ​ ​ ​ and Mexican origin." Four toponyms will be extracted (called Geotagging) and grounded to ​ ​ their geographic coordinates (called Toponym Resolution). However, our research goes further than any previous work by showing how to distinguish the literal place(s) of the event (Spain, Malaga) from other linguistic types/uses such as nationalities (Mexican, American), ​ ​ ​ ​ improving downstream task accuracy. We consolidate and extend the Standard Evaluation Framework, discuss key research problems, then present concrete solutions in order to advance each stage of geoparsing. For geotagging, as well as training a SOTA neural Location-NER tagger, we simplify Metonymy Resolution with a novel minimalist feature extraction combined with an LSTM-based classifier, matching SOTA results. For toponym resolution, we deploy the latest deep learning methods to achieve SOTA performance by augmenting neural models with hitherto unused geographic features called Map Vectors. With each research project, we provide high quality datasets and system prototypes, further building resources in this field. We then show how these geoparsing advances coupled with our proposed Intra-Document Analysis can be used to associate news articles with locations in order to monitor the spread of public health threats. To this end, we evaluate our research contributions with production data from a real-time downstream application to improve geolocation of news events for disease monitoring. The data was made available to us by the ​ Joint Research Centre (JRC), which operates one such system called MediSys that processes incoming news articles in order to monitor threats to public health and make these available to a variety of governmental, business and non-profit organisations. We also discuss steps towards an end-to-end, automated news monitoring system and make actionable recommendations for future work. In summary, the thesis aims are twofold: (1) Generate original geoparsing research aimed at advancing each stage of the pipeline by addressing pertinent challenges with concrete solutions and actionable proposals. (2) Demonstrate how this research can be applied to news event monitoring to increase the efficacy of existing biosurveillance systems, e.g. European Commission’s MediSys. I would like to dedicate this thesis to my loving parents who worked extraordinarily hard to give me this opportunity. Thank You. Acknowledgements I would like to acknowledge the generous funding support of the Natural Environment Research Council (NERC) via the interdisciplinary Centre of Doctoral Training (CDT) called Data, Risk, Environmental and Analytical Methods (DREAM1) under the leadership of Dr Stephen Hallett and Co. of Cranfield University and more locally, Dr Mike Bithell of Cambridge University. The CDT is a great model for PhD students, broadening our horizons, offering excellent support and developing non-academic skills through diverse experiences. Naturally, I want to recognise Dr Nigel Collier for his dedicated supervision throughout the 3-4 years, for co-authoring my papers and having the confidence in me as his next PhD student back in 2015. I also want to thank Dr Anna Korhonen for her dedicated (second) supervision and support throughout the PhD process and for expertly examining the thesis (internal). I further want to thank Dr Mark Stevenson2 from Sheffield University for agreeing to examine my thesis (external) and for providing excellent feedback. I want to acknowledge my fellow authors Dr Nut Limsopatham (2015 - 2017) and Dr Mohammad Taher Pilehvar (2015 - 2019) for their continued advisory support and feedback during manuscript and thesis publication. I extend my gratitude to our industrial partner Dr Jens Linge from the Joint Research Centre of the European Commission for his feedback, collaboration and for hosting me at the JRC in Ispra, Italy in February 2018; the Fitzwilliam College Graduate Officer Sue Free for her support, particularly during my 2018 intermission due to family issues; Savina Velotta and Angela Colclough from DREAM CDT for ensuring the events felt homely and welcoming, enabling us to focus on learning. Last but not least, I thank Cambridge University students Mina Frost and Qianchu (Flora) Liu for providing linguistic expertise; the NVIDIA GPU Grant Program for the free graphics card; my fellow LTL students for their company, support and advice. Finally, Thank You to all who helped out in any way big or small, somehow during my thesis submission and new job busyness, I forgot to acknowledge you, you know who you are, you deserve it. Thank You Very Much! 1http://www.dream-cdt.ac.uk/ 2https://www.sheffield.ac.uk/dcs/people/academic/mstevenson Table of contents List of figures xiii List of tables xvii 1 Introduction1 1.1 Preamble . .2 1.1.1 Thesis Format . .2 1.1.2 Summary of Contributions . .2 1.1.3 Published Papers . .5 1.2 Research Partnerships . .5 1.2.1 DREAM CDT . .5 1.2.2 Joint Research Centre . .6 1.2.3 EMM and MediSys . .6 1.3 Related Work in Biosurveillance . .7 1.3.1 Summary . .9 2 Geoparsing Landscape 11 2.1 Introduction . 11 2.2 What’s Missing in Geoparsing? . 12 2.2.1 Introduction to the Survey . 12 2.2.2 Related Work . 13 2.2.3 Featured Systems . 15 2.2.4 Evaluation Corpora . 18 2.2.5 Evaluation Metrics . 21 2.2.6 Results and Analysis . 24 2.2.7 Discussion and Future Work . 28 2.2.8 Closing Remarks . 31 2.3 Summary . 32 viii Table of contents 3 Handling Metonymy in Geoparsing 33 3.1 Introduction . 33 3.2 Minimalist Metonymy Resolution . 34 3.2.1 Related Work . 35 3.2.2 The ReLocaR Dataset and its Improved Annotation . 36 3.2.3 Predicate Window (PreWin) . 39 3.2.4 Neural Network Architecture . 41 3.2.5 Results and Error Analysis . 42 3.2.6 Discussion . 46 3.2.7 Conclusions . 47 3.3 Summary . 48 4 Toponym Resolution 49 4.1 Introduction . 49 4.2 Geocoding with Map Vector . 50 4.2.1 Related Work . 51 4.2.2 Neural Network Geocoder . 53 4.2.3 The Map Vector (MapVec) . 54 4.2.4 Evaluation Metrics . 57 4.2.5 The GeoVirus Dataset . 59 4.2.6 New SOTA Results . 60 4.2.7 Discussion and Error Analysis . 62 4.2.8 Conclusions . 63 4.3 Summary . 64 5 What’s Next for Geoparsing? 67 5.1 Introduction . 67 5.2 A Pragmatic Guide to Geoparsing Evaluation . 68 5.2.1 Current Challenges . 68 5.2.2 Summary of the most salient findings . 70 5.2.3 Related Work . 70 5.2.4 Geographic datasets and the pragmatics of toponyms . 71 5.3 A Pragmatic Taxonomy of Toponyms . 74 5.3.1 Non-Toponyms . 75 5.3.2 Literal Toponyms . 75 5.3.3 Associative Toponyms . 78 5.4 Standard Evaluation Metrics . 80 Table of contents ix 5.4.1 Geotagging Metrics . 81 5.4.2 Toponym Resolution Metrics . 81 5.4.3 Recommended Metrics for Toponym Resolution . 83 5.4.4 Important Considerations for Evaluation . 83 5.4.5 Unsuitable Datasets . 85 5.4.6 Recommended Datasets . 86 5.5 GeoWebNews . 86 5.5.1 Annotation Procedure and Inter-Annotator Agreement (IAA) . 87 5.5.2 Annotation of Coordinates . 88 5.5.3 Evaluation . 88 5.5.4 Conclusion and Future Work . 92 5.5.5 Closing Thoughts . 93 6 Geoparsing for Disease Monitoring 95 6.1 Introduction . 95 6.2 Geoparsing Evaluation . 96 6.2.1 MediSys News Stream . 96 6.2.2 MediSys Geotagging . 97 6.2.3 MediSys Toponym Resolution . 99 6.3 FlexiGraph . 101 6.4 Geolocation System Proposals . 104 6.4.1 Literal and Associative Types . 105 6.5 Summary . 109 7 Conclusion 111 7.1 Synopsis . 111 7.2 Discussion: Towards Robust Biosurveillance . 112 7.2.1 Disease Monitoring, NLP and System Risks . 114 7.3 Future Work . 116 7.4 Summary . 120 References 123 Appendix A Supplementary Materials 139 A.1 Quoted News Text . 139 List of figures 2.1 The geoparsing pipeline comprises two main stages geotagging and geocod- ing. Geotagging retrieves only literal toponyms (ideally filtering metonymic occurrences) from text and generates candidate coordinates for each. Geocod- ing then leverages the surrounding context to choose the correct coordinate and link the mention to an entry in a geographical knowledge base.
Recommended publications
  • Membership Recognition
    Membership Recognition AIST takes this opportunity to recognize our members for their years of loyalty and ongoing commitment to the iron and steel industry. Each year, AIST publishes a roster of individuals reaching significant anniversaries of membership, beginning with 10 years and continuing with each successive five-year anniversary. AIST Members Celebrating an Anniversary in 2014 50+ Consecutive Years of Membership Jagdish C. Agarwal Lowell L. French Otto J. Leone Jr. Walter D. Sadowski L. James Anderson Gordon H. Geiger Edward C. Levy Jr. Norman L. Samways Shank R. Balajee Carl E. Glaser Timothy Lewis S.D. Sanders John A. Beatrice Henry G. Goehring Louis W. Lherbier Nobuo Sano Joel Gary Bernstein Thomas C. Graham Claude H.P. Lupis Edward J. Schaming William H. Betts James F. Hamilton Raymond M. Mader Winfried F. Schmiedberg Kenneth E. Blazek Narwani Harman Alexander McLean William A. Schmucker David T. Blazevic Roger Heaton Akgun Mertdogan Herbert D. Sellers Sr. Gary L. Bowman John D. Heffernan Royston P. Morgan Sudhir K. Sharma John C. Campbell Harry O. Hefter Paul R. Morrow Bruce M. Shields Richard J. Choulet Wallace L. Hick Jr. John M. Negomir Charles E. Slater Thomas A. Cleary Jr. Edwin M. Horak Sanford M. Nobel Ralph M. Smailer C. Larry Coe Tobin Humphrey John C. Pearl Russell Solomon III Denis L. Creazzi George A. Jedenoff K.G. Pedersen George R. St. Pierre Charles Criss John E. Jetkiewicz Robert D. Pehlke Barry A. Strathdee Roy L. Cross Behram M. Kapadia Raymond L. Polick Joseph M. Strouse Jr. James F. Cunningham Clifford W. Kehr K.
    [Show full text]
  • Language Models As Knowledge Bases: on Entity Representations, Storage Capacity, and Paraphrased Queries
    Language Models as Knowledge Bases: On Entity Representations, Storage Capacity, and Paraphrased Queries Benjamin Heinzerling1, 2 and Kentaro Inui2, 1 1RIKEN AIP & 2Tohoku University [email protected] j [email protected] Abstract Pretrained language models have been sug- gested as a possible alternative or comple- ment to structured knowledge bases. However, this emerging LM-as-KB paradigm has so far only been considered in a very limited setting, which only allows handling 21k entities whose Figure 1: The LM-as-KB paradigm, introduced by name is found in common LM vocabularies. Petroni et al.(2019). A LM memorizes factual state- Furthermore, a major benefit of this paradigm, ments, which can be queried in natural language. i.e., querying the KB using natural language paraphrases, is underexplored. Here we formu- However, this emerging LM-as-KB paradigm is late two basic requirements for treating LMs as KBs: (i) the ability to store a large num- faced with several foundational questions. ber facts involving a large number of entities First question: KBs contain millions of entities, and (ii) the ability to query stored facts. We while LM vocabulary size usually does not exceed explore three entity representations that allow 100k entries. How can millions of entities be rep- LMs to handle millions of entities and present resented in LMs? Petroni et al.(2019) circum- a detailed case study on paraphrased querying vent this problem by only considering 21k enti- of facts stored in LMs, thereby providing a ties whose canonical name corresponds to a single proof-of-concept that language models can in- deed serve as knowledge bases.
    [Show full text]
  • Post-Translational Modification of MRE11: Its Implication in DDR And
    G C A T T A C G G C A T genes Review Post-Translational Modification of MRE11: Its Implication in DDR and Diseases Ruiqing Lu 1,† , Han Zhang 2,† , Yi-Nan Jiang 1, Zhao-Qi Wang 3,4, Litao Sun 5,* and Zhong-Wei Zhou 1,* 1 School of Medicine, Sun Yat-Sen University, Shenzhen 518107, China; [email protected] (R.L.); [email protected] (Y.-N.J.) 2 Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College; Kunming 650118, China; [email protected] 3 Leibniz Institute on Aging–Fritz Lipmann Institute (FLI), 07745 Jena, Germany; zhao-qi.wang@leibniz-fli.de 4 Faculty of Biological Sciences, Friedrich-Schiller-University of Jena, 07745 Jena, Germany 5 School of Public Health (Shenzhen), Sun Yat-Sen University, Shenzhen 518107, China * Correspondence: [email protected] (L.S.); [email protected] (Z.-W.Z.) † These authors contributed equally to this work. Abstract: Maintaining genomic stability is vital for cells as well as individual organisms. The meiotic recombination-related gene MRE11 (meiotic recombination 11) is essential for preserving genomic stability through its important roles in the resection of broken DNA ends, DNA damage response (DDR), DNA double-strand breaks (DSBs) repair, and telomere maintenance. The post-translational modifications (PTMs), such as phosphorylation, ubiquitination, and methylation, regulate directly the function of MRE11 and endow MRE11 with capabilities to respond to cellular processes in promptly, precisely, and with more diversified manners. Here in this paper, we focus primarily on the PTMs of MRE11 and their roles in DNA response and repair, maintenance of genomic stability, as well as their Citation: Lu, R.; Zhang, H.; Jiang, association with diseases such as cancer.
    [Show full text]
  • Colorectal Cancer SCHWEIZER Dezember 2013 04
    Dezember 2013 04 Erscheint vierteljährlich Jahrgang 33 DU CANCER SCHWEIZER KREBSBULLETIN BULLETIN SUISSE Via Ernährung das Darmkrebsrisiko senken, S. 337 Schwerpunkt: Colorectal Cancer BAND 33, DEZEMBER 2013, AUFLAGE 4200 INHALTSVERZEICHNIS Editorial KLS Krebsliga Schweiz 334 Würdigung herausragender Verdienste für krebsbetroffene 281-282 After and before WOF Menschen F. Cavalli K. Bodenmüller Pressespiegel 335 Brustzentrum des Kantonsspitals Baden mit Qualitätslabel ausgezeichnet 285-290 Cancer in the media K. Bodenmüller Schwerpunktthema 336 Brustkrebs: Eine Anziehpuppe erleichtert Gespräche Colorectal cancer zwischen Eltern und Kindern S. Jenny 293-295 Colorectal cancer: much has been done, but there is still a long way to go 337 Via Ernährung das Darmkrebsrisiko senken P. Saletti K. Zuk 296-298 Kolonkarzinomscreening 2013: Sind wir einen Schritt 338 Un honneur qui récompense de grands mérites en faveur weiter? des personnes atteintes du cancer U.A. Marbet, P. Bauerfeind K. Bodenmüller 339 Remise du label de qualité au Centre du sein de l’Hôpital 299 Kolorektales Karzinom in der Schweiz cantonal de Baden M. Montemurro K. Bodenmüller 300-301 Kassenpflicht für Kolonkarzinom-Früherkennung 340 Nouvelle formation continue en psycho-oncologie K. Haldemann Interview avec Dr. Friedrich Stiefel V. Moser Celio 302-306 Epidémiologie et prise en charge du cancer colorectal: une étude de population en Valais 342 Fort- und Weiterbildungen der Krebsliga Schweiz I. Konzelmann, S. Anchisi, V. Bettschart, J.-L. Bulliard, Formation continue de la Ligue suisse contre le cancer A. Chiolero OPS Onkologiepflege Schweiz Originalartikel 344-346 Hautveränderungen bei antitumoralen Therapien S. Wiedmer 309-313 Neglected symptoms in palliative cancer care T. Fusi, P. Sanna SGMO Schweizerische Gesellschaft 315-318 Multidisciplinary management of urogenital für Medizinische Onkologie tumours at the Ente Ospedaliero Cantonale 349 Elektronisches Patientendossier und Behandlungspfade E.
    [Show full text]
  • Curriculum Vitae
    CURRICULUM VITAE Angelo Auricchio, M.D., Ph.D., F.E.S.C PERSONAL Citizenship status Italian Date of birth August 24, 1960 Place of birth Terzigno, Italy Marital status Married, 3 children Mailing address Division of Cardiology Istituto Cardiocentro Ticino Via Tesserete 48 CH-6900 Lugano Switzerland Business Phone + 41 91 805 3879 Fax + 41 91 805 3213 Email [email protected] Languages Italian, English, and German OrcID https://orcid.org/0000-0003-2116-6993 EDUCATION 1979 – 1985 Medical School, Federico II - University of Naples, Italy 1985 – 1989 Specialization in Cardiology, Federico II - University of Naples, 1 Italy 1991 – 1994 Dottorato di Ricerca in Fisiopatologia Cardiovascolare, University of Rome “Tor Vergata”, Rome, Italy TRAINING Internship 1981 – 1983 Department of Microbiology, University of Naples, Italy 1983 – 1985 Department of Metabolic Diseases, University of Naples, Italy Internal Medicine Resident 1985 – 1986 Department of Internal Medicine, University Hospital, Naples, Italy Cardiology Fellow 1986 – 1988 Division of Cardiology, University Hospital, Naples, Italy 1988 – 1991 Division of Cardiology, University Hospital, Hannover, Germany CERTIFICATION 1985 MD – degree, Naples, Italy 1988 Board of Cardiology, Naples, Italy HOSPITAL APPOINTMENTS 1986 – 1988 Assistant Staff Physician, University Hospital, Naples, Italy 1988 – 1991 Assistant Staff Physician, University Hospital, Hannover, Germany 1991 – 1994 Attending Physician, Division of Cardiac Surgery, University Hospital Rome, Italy VI-VIII 1994 Visiting
    [Show full text]
  • BASEBALL 2007 Roster 5 2007 Preview 6 Schedule 2007 Seawolves 7-14 DATE OPPONENT LOCATION TIME 2006 Review Fri-Feb
    Table of Contents 2007 Information 2007 Seawolves Schedule 1 Head Coach John Goelz 2 Assistant Coaches 3-4 BASEBALL 2007 Roster 5 2007 Preview 6 Schedule 2007 Seawolves 7-14 DATE OPPONENT LOCATION TIME 2006 Review Fri-Feb. 2 CAL STATE MONTEREY BAY ROHNERT PARK 2:00 pm 2006 Highlights 16 Sat-Feb. 3 CAL STATE MONTEREY BAY (dh) ROHNERT PARK 11:00 am 2006 Results 16 Tue-Feb. 6 SAN FRANCISCO STATE ROHNERT PARK 2:00 pm 2006 Statistics 17-19 Thu-Feb. 8 WESTERN OREGON ROHNERT PARK 2:00 pm 2006 Honors 19 Sat-Feb. 10 Western Oregon San Francisco, Calif 2:00 pm 2006 CCAA Standings 20 Fri-Feb. 16 Grand Canyon Phoenix, Ariz 5:00 pm 2006 All-Conference Honors 20 2006 CCAA Leaders 21 Sat-Feb. 17 Grand Canyon (dh) Phoenix, Ariz 12:00 pm Sun-Feb. 18 Grand Canyon Phoenix, Ariz 11:00 am SSU Baseball History Sat-Feb. 24 CAL STATE STANISLAUS* (dh) ROHNERT PARK 11:00 am Yearly Team Honors 22 Sun-Feb. 25 CAL STATE STANISLAUS* (dh) ROHNERT PARK 11:00 am All-Time Awards 22-23 Fri-Mar. 2 UC SAN DIEGO* ROHNERT PARK 2:00 pm All-Americans 24 Sat-Mar. 3 UC SAN DIEGO* (dh) ROHNERT PARK 11:00 am All-Time SSU Baseball Team 25 Sun-Mar. 4 UC SAN DIEGO* ROHNERT PARK 11:00 am Yearly Leaders 26-27 Fri-Mar. 9 Cal State Dominguez Hills* Carson, Calif 2:00 pm Records 28-30 Sat-Mar. 10 Cal State Dominguez Hills* (dh) Carson, Calif 11:00 am Yearly Team Statistics 30 Sun-Mar.
    [Show full text]
  • Search Unclaimed Property
    VOL P. 3835 FRIDAY, JUNE 15, 2018 THE LEGAL INTELLIGENCER • 19 SEARCH UNCLAIMED PROPERTY Philadelphia County has unclaimed property waiting to be claimed. For information about the nature and value of the property, or to check for additional names, visit www.patreasury.gov Pennsylvania Treasury Department, 1-800-222-2046. Notice of Names of Persons Appearing to be Owners of Abandoned and Unclaimed Property Philadelphia County Listed in Alphabetical Order by Last Known Reported Zip Code Philadelphia County Southern Bank Emergency Physicians Hyun Heesu Strange Timothy L Caul Almena D Southernmost Emergency Irrevocable Trust of Kathleen Rafferty Stursberg Henry J Cera Robert A Spectrum Emergency Care Ishikawa Masahiro Suadwa Augustine A Chakravarty Rajit 19019 Spiritual Frontiers Fellowship Jack Paller and Company Inc Sulit Jeremy William Chang Dustin W Buck Mary Stantec Consulting Services Jacob I Hubbart Pennwin Clothes Corp Sullivan Thomas J Chao Shelah Burlington Anesthesia Assoc Su Ling Jaffe Hough Taylor Ronald Charlotte Field Davis Catherine C Taylor Kyle W W Jain Monica Thales Avionics Inc Chca Inc Oncology Decicco Mary Tchefuncta Emerg Phys Jdjs Inc The Sun Coast Trade Exchange Checker Cab Company Inc Dittus Betty Teleflex Automotive Group Jeffrey R Lessin Associates The Vesper Club Chen Kesi Grzybows Kathryn Texas Emi Medical Services Jeffrey Reiff Trust Thompson Howard Chen Roberta Hawley Philip E Thompson Barbara Johnson Jerry A Thompson Kathleen M Chernukhina Evgeniya A Huber Catherine L Thompson Marjorie Jones Chanie B Thurlow
    [Show full text]
  • PHYSICS PUBLICATIONS JLAB NUMBER TITLE of PAPER AUTHOR(S) Published? Year Month JOURNAL REFERENCE Published FY09 AFTER Science and Technology Review
    PHYSICS PUBLICATIONS JLAB NUMBER TITLE OF PAPER AUTHOR(S) Published? Year month JOURNAL REFERENCE Published FY09 AFTER Science and Technology Review JLAB-PHY-08-872 Measurement of unpolarized semi-inclusive pi+ M. Osipenko, M. Ripani, G. Ricco, H. Avakian, R. De Vita, G. Yes 2009 August Phys.Rev.D80:032004,2009 electroproduction off the proton Adams, M.J. Amaryan, P. Ambrozewicz, M. Anghinolfi, G. Asryan, G. Audit, H. Bagdasaryan, N. Baillie, J.P. Ball, N.A. Baltzell, S. Barrow, M. Battaglieri, I. Bedlinskiy, M. Bektasoglu, M. Bellis, N. Benmouna, B.L. Berman, A.S. Biselli, L. Blaszczyk, B.E. Bonner, S. Bouchigny, S. Boiarinov, R. Bradford, D. Branford, W.J. Briscoe, W.K. Brooks, S. Bueltmann, V.D. Burkert, C. Butuceanu, J.R. Calarco, S.L. Careccia, D.S. Carman, A. Cazes, F. Ceccopieri, S. Chen, P.L. Cole, P. Collins, P. Coltharp, P. Corvisiero, D. Crabb, V. Crede, J.P. Cummings, N. Dashyan, R. De Masi, E. De Sanctis, P.V. Degtyarenko, H. Denizli, L. Dennis, A. Deur, K.V. Dharmawardane, K.S. Dhuga, R. Dickson, C. Djalali, G.E. Dodge, J. Donnelly, D. Doughty V. Drozdov, M. Dugger, S. Dytman, O.P. Dzyubak, H. Egiyan, K.S. Egiyan, L. El Fassi, L. Elouadrhiri, P. Eugenio, R. Fatemi, G. Fedotov, G. Feldman, R.J. Feuerbach, H. Funsten, M. Gar¸con, G. Gavalian G.P. Gilfoyle, K.L. Giovanetti, F.X. Girod, J.T. Goetz, E. Golovach, A. Gonenc, C.I.O. Gordon, R.W. Gothe, K.A. Griffioen, M. Guidal, M. Guillo, N. Guler, L. Guo, V. Gyurjyan, C.
    [Show full text]
  • Personalized Immunotherapy Against Several Neuronal and Brain Tumors
    (19) TZZ¥¥ T (11) EP 3 539 979 A2 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 18.09.2019 Bulletin 2019/38 C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) C07K 7/06 (2006.01) (2006.01) (21) Application number: 19166517.3 C07K 7/08 (22) Date of filing: 03.11.2014 (84) Designated Contracting States: • Walter, Steffen AL AT BE BG CH CY CZ DE DK EE ES FI FR GB Houston, TX 77005 (US) GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO • Hilf, Norbert PL PT RO RS SE SI SK SM TR 72138 Kirchentellinsfurt (DE) Designated Extension States: • Schoor, Oliver BA ME 72074 Tübingen (DE) • Singh, Harpreet (30) Priority: 04.11.2013 GB 201319446 80804 München (DE) 04.11.2013 US 201361899680 P • Kuttruff-Coqui, Sabrina 70794 Filderstadt-Sielmingen (DE) (62) Document number(s) of the earlier application(s) in • Song, Colette accordance with Art. 76 EPC: 73760 Ostfildern (DE) 14792834.5 / 3 066 115 (74) Representative: Krauss, Jan (27) Previously filed application: Boehmert & Boehmert 03.11.2014 PCT/EP2014/073588 Anwaltspartnerschaft mbB Pettenkoferstrasse 22 (71) Applicant: Immatics Biotechnologies GmbH 80336 München (DE) 72076 Tübingen (DE) Remarks: (72) Inventors: This application was filed on 01.04.2019 as a • Weinschenk, Toni divisional application to the application mentioned 73773 Aichwald (DE) under INID code 62. • Fritsche, Jens 72144 Dusslingen (DE) (54) PERSONALIZED IMMUNOTHERAPY AGAINST SEVERAL NEURONAL AND BRAIN TUMORS (57) The present invention relates to peptides, nu- ceutical ingredients of vaccine compositions that stimu- cleic acids and cells for use in immunotherapeutic meth- late anti-tumor immune responses.
    [Show full text]
  • Curitiba, 8 De Outubro De 2018 - Edição Nº 2361 - 273 Páginas
    Curitiba, 8 de Outubro de 2018 - Edição nº 2361 - 273 páginas Sumário Tribunal de Justiça .......................................................................... 2 Sistemas de Juizados Especiais Cíveis e Criminais .................... 134 Atos da Presidência ..................................................................... 2 Comarca da Capital ......................................................................... 134 Concursos ................................................................................ 2 Direção do Fórum ....................................................................... 134 Supervisão do Sistema da Infância e Juventude ..................... 2 Cível ............................................................................................ 134 Atos da 1ª Vice-Presidência ........................................................ 2 Crime .......................................................................................... 162 Atos da 2ª Vice-Presidência ........................................................ 2 Fazenda Pública .......................................................................... 162 Supervisão do Sistema de Juizados Especiais ........................ 4 Família ........................................................................................ 166 NUPEMEC ............................................................................. 4 Delitos de Trânsito ...................................................................... 166 Secretaria ....................................................................................
    [Show full text]
  • San Mateo County Naturalization Index 1907-1925 San Mateo County Late 1906 Through 1925
    San Mateo County Naturalization Index 1907-1925 San Mateo County Genealogical Society 1999 San Mateo County Naturalization Index Volume 2 1907-1925 Project Co-ordinator/ Editor Cath Trindle San Mateo County Genealogical Society © 1999 Record Entry Cath Trindle, Ken & Pam Davis, Mary Lou Grunigen, Margaret Deal, Janice Marshall Proof-reading and Corrections Cath Trindle, Jack Goodwin, Ann Smith, Florence Christensen, Shirley Bittancourt, Vivian Goodwin, Millie Clough © July 1999 San Mateo County Genealogical Society Library of Congress Catalog Car Number 99-071151 Order Copies from the Publisher: San Mateo County Genealogical Society PO Box 5083 San Mateo CA 94402 Table of Contents San Mateo County Oct 1906-1925 ..................................... ii Overview of the Naturalization Records ...................................iv Naturalization Index .................................................. 1 Bibliography ....................................................... 152 SMCGS Archives Project i San Mateo County Naturalization Index 1907-1925 San Mateo County Late 1906 through 1925 When the naturalization process was first slated to change in September of 1906 no one was anticipating the earth shattering moments That were to devastate the San Francisco bay area on April 18. Destruction dotted the peninsula including new court house. But an even greater impact was felt within San Mateo County as this home to only 12000 people in 1900 was flooded with refugees from the completely devastated San Francisco. Development within the county during the ensuing years was strongly influenced by geography. The bay side was served by the San Francisco Railroad which facilitated movement and inspired urban development. Businesses tended to set up on water level sites while residential areas gravitated towards the gently sloping hills. By 1910 the population had nearly doubled to 20,600.
    [Show full text]
  • Administrativa E Judicial
    ADMINISTRATIVADiário da Justiça E JUDICIAL Eletrônico - RS - Administrativa e Judicial Edição Nº 6.397 / Disponibilização:Edição Nº 6.122Terça-feira, / Disponibilização: 27 de Novembro Quinta-feira, de28 de2018 Setembro1 de 2017 1 DIÁRIODIÁRIO DA ELETRÔNICOJUSTIÇA ELETRÔNICO DA JUSTIÇA DODO ESTADOESTADO DO DO RIO RIO GRANDE GRANDE DO DOSUL SUL LeiLei nº nº 11.419 11.419 de 19/12/0619/12/06 ADMINISTRATIVAADMINISTRATIVA EE JUDICIAL JUDICIAL ATOS DA PRESIDÊNCIA SERVIÇO DE PROCESSAMENTO DE PRECATÓRIOS NOTA DE EXPEDIENTE Nº 2338/2018-SPP FORAM DESPACHADOS OS PROCESSOS ABAIXO RELACIONADOS, COM AS SEGUINTES DECISÕES: PRECATÓRIO 20116 - 006611/0300/00-1 - 4ª VARA DA FAZENDA PÚBLICA DE PORTO ALEGRE - EXECUÇÃO PROVISÓRIA Nº 110503083759 - SUELLY ROSA PIRILLO PARANHOS (GABRIELI KURZ PERES - RS/60844 , MATEUS FETTER DE ALMEIDA - RS/58947 , NELSON LACERDA DA SILVA - RS/39797 , RAFAEL KURZ PERES - RS/51203 , TELMO RICARDO ABRAHÃO SCHORR - RS/32158 ) X INSTITUTO DE PREVIDÊNCIA DO ESTADO (CRISTIANO XAVIER BAYNE - RS/46302). “DIANTE DAS DECISÕES NOS AUTOS DO PRESENTE PRECATÓRIO, PREJUDICADO A SOLICITAÇÃO QUE CULMINOU NA EXPEDIÇÃO DA NE 1630/2018, RAZÃO PELA QUAL INDEFERIDO O PEDIDO DE REABERTURA DE PRAZO. DIANTE DOS TERMOS DA CERTIDÃO ORIUNDA DO JUÍZO DE ORIGEM JUNTADA AO PRESENTE PRECATÓRIO, DEFERIDO O PEDIDO DE HABILITAÇÃO DO CESSIONÁRIO COMEC COMÉRCIO DE MÁQUINAS LTDA, NOS TERMOS DO ATO Nº 023/2017-P DO TJRS. PROCEDIDO AO CADASTRAMENTO E INCLUSÃO DO CESSIONÁRIO HABILITADO NA ORIGEM COMO BENEFICIÁRIO DO PRESENTE PRECATÓRIO, OBSERVADO O PERCENTUAL CONSIGNADO
    [Show full text]