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Phaeochromocytoma Paraganglioma Structured Reporting Protocol PHAEOCHROMOCYTOMA & PARAGANGLIOMA STRUCTURED REPORTING PROTOCOL (1st Edition 2020) Incorporating the: International Collaboration on Cancer Reporting (ICCR) Phaeochromocytoma and Paraganglioma Dataset www.ICCR-Cancer.org Core Document versions: • ICCR dataset: Phaeochromocytoma and Paraganglioma 1st edition v1.01 • AJCC Cancer Staging Manual 8th edition2 • World Health Organization (2017) Classification of Tumours of Endocrine Organs (4th edition). Volume 10.3 2 Structured Reporting Protocol for Phaeochromocytoma and Paraganglioma 1st edition ISBN: 978-1-76081-422-9 Publications number (SHPN): (CI) 200279 Online copyright © RCPA 2020 This work (Protocol) is copyright. You may download, display, print and reproduce the Protocol for your personal, non-commercial use or use within your organisation subject to the following terms and conditions: 1. The Protocol may not be copied, reproduced, communicated or displayed, in whole or in part, for profit or commercial gain. 2. Any copy, reproduction or communication must include this RCPA copyright notice in full. 3. With the exception of Chapter 6 - the checklist, no changes may be made to the wording of the Protocol including any Standards, Guidelines, commentary, tables or diagrams. Excerpts from the Protocol may be used in support of the checklist. References and acknowledgments must be maintained in any reproduction or copy in full or part of the Protocol. 4. In regard to Chapter 6 of the Protocol - the checklist: • The wording of the Standards may not be altered in any way and must be included as part of the checklist. • Guidelines are optional and those which are deemed not applicable may be removed. • Numbering of Standards and Guidelines must be retained in the checklist, but can be reduced in size, moved to the end of the checklist item or greyed out or other means to minimise the visual impact. • Additional items for local use may be added but must not be numbered as a Standard or Guideline, in order to avoid confusion with the RCPA checklist items. • Formatting changes in regard to font, spacing, tabulation and sequencing may be made. • Commentary from the Protocol may be added or hyperlinked to the relevant checklist item. Apart from any use as permitted under the Copyright Act 1968 or as set out above, all other rights are reserved. Requests and inquiries concerning reproduction and rights should be addressed to RCPA, 207 Albion St, Surry Hills, NSW 2010, Australia. First published: June 2020, 1st Edition (version 1.0) 3 Structured Reporting Protocol for Phaeochromocytoma and Paraganglioma 1st edition Disclaimer The Royal College of Pathologists of Australasia ("College") has developed these protocols as an educational tool to assist pathologists in reporting of relevant information for specific cancers. While each protocol includes “standards” and “guidelines” which are indicators of ‘minimum requirements’ and ‘recommendations’, the protocols are a first edition and have not been through a full cycle of use, review and refinement. Therefore, in this edition, the inclusion of “standards” and “guidelines” in each document are provided as an indication of the opinion of the relevant expert authoring group, but should not be regarded as definitive or as widely accepted peer professional opinion. The use of these standards and guidelines is subject to the clinician’s judgement in each individual case. The College makes all reasonable efforts to ensure the quality and accuracy of the protocols and to update the protocols regularly. However subject to any warranties, terms or conditions which may be implied by law and which cannot be excluded, the protocols are provided on an "as is" basis. The College does not warrant or represent that the protocols are complete, accurate, error-free, or up to date. The protocols do not constitute medical or professional advice. Users should obtain appropriate medical or professional advice, or where appropriately qualified, exercise their own professional judgement relevant to their own particular circumstances. Users are responsible for evaluating the suitability, accuracy, currency, completeness and fitness for purpose of the protocols. Except as set out in this paragraph, the College excludes: (i) all warranties, terms and conditions relating in any way to; and (ii) all liability (including for negligence) in respect of any loss or damage (including direct, special, indirect or consequential loss or damage, loss of revenue, loss of expectation, unavailability of systems, loss of data, personal injury or property damage) arising in any way from or in connection with; the protocols or any use thereof. Where any statute implies any term, condition or warranty in connection with the provision or use of the protocols, and that statute prohibits the exclusion of that term, condition or warranty, then such term, condition or warranty is not excluded. To the extent permitted by law, the College's liability under or for breach of any such term, condition or warranty is limited to the resupply or replacement of services or goods. 4 Structured Reporting Protocol for Phaeochromocytoma and Paraganglioma 1st edition Contents Scope ........................................................................................ 6 Definitions .................................................................................. 8 Introduction................................................................................ 11 Authority and development ............................................................ 15 1 Pre-analytical ......................................................................... 18 2 Specimen handling and macroscopic findings .............................. 20 3 Microscopic findings ............................................................... 26 4 Ancillary studies findings ........................................................ 32 5 Synthesis and overview ........................................................... 35 6 Structured checklist ................................................................ 37 7 Formatting of pathology reports ................................................ 53 Appendix 1 Pathology request form for adrenal medulla tumours ........ 54 Appendix 3 Example of a pathology report ..................................... 60 Appendix 4 WHO histological classification .................................... 64 References ................................................................................. 65 5 Structured Reporting Protocol for Phaeochromocytoma and Paraganglioma 1st edition Scope This protocol contains standards and guidelines for the structured reporting of adrenalectomy/partial adrenalectomy specimens for phaeochromocytoma, other excisions for paragangliomas, and biopsies of related specimens. Not covered in this protocol are: sarcoma, lymphoma, metastasis to the adrenal medulla, neuroblastoma and ganglioneuroblastoma specimens. Adrenal cortical tumours are dealt with in a separate protocol. Structured reporting aims to improve the completeness and usability of pathology reports for clinicians and improve decision support for cancer treatment. This protocol can be used to define and report the minimum dataset, but the structure is scalable and can equally accommodate a maximum data set or fully comprehensive report. 6 Structured Reporting Protocol for Phaeochromocytoma and Paraganglioma 1st edition Abbreviations AJCC American Joint Committee on Cancer GAPP Grading system for Adrenal Phaeochromocytoma and Paraganglioma HPF High power fields ICCR International Collaboration on Cancer Reporting IHI Individual Healthcare Identifier LIS The laboratory information system MEN2 Multiple endocrine neoplasia type 2 mm Millimetres NHMRC NationalS Standard Health and Medical Research Council PASS Phaeochromocytoma of the Adrenal gland Scaled Score G Guide RCPA Royal College of Pathologists of Australasia TNM Tumour-node-metastasis UICC International Union Against Cancer UK United Kingdom WHO World Health Organization 7 Structured Reporting Protocol for Phaeochromocytoma and Paraganglioma 1st edition Definitions The table below provides definitions for general or technical terms used in this protocol. Readers should take particular note of the definitions for ‘standard’, ‘guideline’ and ‘commentary’, because these form the basis of the protocol. Ancillary study An ancillary study is any pathology investigation that may form part of a cancer pathology report but is not part of routine histological assessment. Clinical Patient information required to inform pathological assessment, information usually provided with the specimen request form, also referred to as ‘pre-test information’. Commentary Commentary is text, diagrams or photographs that clarify the standards (see below) and guidelines (see below), provide examples and help with interpretation, where necessary (not every standard or guideline has commentary). Commentary is used to: • define the way an item should be reported, to foster reproducibility • explain why an item is included (e.g. how does the item assist with clinical management or prognosis of the specific cancer). • cite published evidence in support of the standard or guideline • state any exceptions to a standard or guideline. In this document, commentary is prefixed with ‘CS’ (for commentary on a standard) or ‘CG’ (for commentary on a guideline), numbered to be consistent with the relevant standard or guideline, and with sequential alphabetic lettering within each set of commentaries (e.g. CS1.01a,
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