Formulating an Improved Insect Repellent with Wacker Cyclodextrins

CREATING TOMORROW’S SOLUTIONS

INFO SHEET I INSECT-REPELLENT FORMULATIONS I CAVAMAX® AND CAVASOL®

FORMULATING AN IMPROVED INSECT REPELLENT WITH WACKER CYCLODEXTRINS

Formulating an insect repellent is more Variety of Natural and Synthetic Extended Protection with Proven challenging today than ever. Consum- Actives Efficacy ers want maximum relief, minimum WACKER’s cyclodextrins can extend the Tests with female Aedes aegypti mosqui- number of applications, an extended protection time of most volatile substances, toes have shown that CAVASOL® cyclo- protection time and a choice of natural for example: dextrin derivatives can extend the protection or synthetic active ingredients. Most • Plant extract oils: citronella, camphor, time of commercial formulations by up to insect repellents, both natural and cinnamon, clove, etc. 80% (@ 0.05% CAVASOL® W7HP added synthetic, are very volatile, which • Pure natural ingredients: geraniol, to the commercial formulation). complicates the process of offering limonene, p-menthane-3,8-diol, etc. an effective and long-lived product. • Synthetic ingredients: pyrethroids, WACKER cyclodextrins provide in- DEET, etc. creased flexibility for the formulator to meet today’s consumer demands.

Figure 1: Volatile Repellent Forms Barrier around Treated Area

Test setup at mosquito laboratory. As long as the surrounding air is saturated with the active ingredient, all mosquitoes are deterred. Innovation by WACKER Product Protection Time Formulations containing WACKER cyclo- Commercial 2.30 hours dextrins, i.e. complexes of cyclodextrin formulation and volatile insect repellent, can help Commercial 4.30 hours meet the formulation challenge of: formulation with CAVASOL® W7HP • Extended protection time • Increasing solubility of active Protection time of formulations with and without • Ability to use water-insoluble actives cyclodextrins. • Utilization in a variety of application modes (pump spray, aerosol and cream)

CAVAMAX® and CAVASOL® are registered trademarks of Wacker Chemie AG. inclusion complexes (seeFig.2and5). of guestmoleculesto formnon-covalent capable ofinteracting withalarge variety and hydrophilic outer they are surfaces, bonds. Withtheirlipophilicinnercavities units, attachedbya containing atleastsixD-(+)-glucopyranose Cyclodextrins are cyclicoligosaccharides, Work WACKER Cyclodextrins –HowThey Recommendations for use do not constitute a warranty, either express or implied, of the fitness or suitability of the product for a particular purpose. particular a for product the of suitability or fitness the of position. the implied, or clarifying express either necessary, if a warranty, and, rights constitute not do use parties’ for third of infringement Recommendations of information The possibility the used. being also investigating are of materials obligation raw the from user companies’ the other absolve where not does us by especially provided control, no have we by which over checked be should processing medium during this in made conditions of because recommendations The trials developments. preliminary new or receipt. on progress technical of immediately scope the supplies all within checking constants carefully product from alter to user the right the absolve not do We reserve but knowledge our of state present the with accordance in are medium this in presented data The [email protected], www.wacker.com, www.wacker.com/socialmedia Wacker ChemicalCorp.,Tel. +15172648436 Wacker ChemieAG, Tel. +4986778386906 Concentration ofRepellentover4Hours Figure 3:TheGraph ShowstheDecreasing Figure 2:Cyclodextrin S Repellent concentration HO

0 1 2 3 4

O Pure repellent O HO O HO HO OH O HO HO OH repellent too low O O HO

O OH O HO HO

OH -(1,4) glycosidic Concentration ofreleased O OH HO tructure OH O HO OH O O HO O OH O OH Time [h]

low concentrations ofCAVASOL of time.Inorder to obtainthiseffect,only released more evenlyoveralongerperiod ensure thattherepellency product is initial boostofactiveingredient. Theywill the down WACKER slow cyclodextrins will dextrins needto beadded.

of theActiveIngredient Ingredients Can InfluencetheRelease Inert Figure 4:TheAdditionofC Repellent concentration

O 0 1 2 3 4

Pure repellent

O repellent too low

5 67

Concentration ofreleased yclodextrins as (1:1) CAVASOL repellent with Physical mixture of CAVASOL repellent with Physical mixture of (1:0.05)

HO ®

OH cyclo-

O ® ® W7HP W7HP Time [h]

CREATING TOMORROW’S SOLUTIONS

• • • • WACKER cyclodextrins Advantages ataGlance a Cyclodextrin-G Figure 5:SchematicRepresentation of commercially usedinsectrepellents Have beentested onawidevarietyof effective use which usuallydissipate too quicklyfor Enable theuseofhighlyvolatilesubstances products atsmallpercentage additions Increase theprotection timeofrepellency Can ingredients beaddedasinert uest C omplex

7440e/01.17