Oncogene (2002) 20, 8378 ± 8392 ã 2002 Nature Publishing Group All rights reserved 0950 ± 9232/02 $25.00 www.nature.com/onc Volume 20 keyword index

11q23 ± q24 7753 Acute lymphoblastic AFP-GC (AFP Animal models 5726, 14-3-3 1839, 3949, 4393, leukemia 3969 producing gastric 7216 5087, 6331 Acute lymphocytic ) 869 Anisomycin 2243 14-3-3 s 3348 leukemias 874 AG490 7925 Anoikis 4710, 6960, 7413 14-3-3 346 Acute myelogeneous Aggressive ®bromatosis Anthracyclin 859 14q32.1 5638 leukemia 88 451 Anti-angiogenic signal- 1a,25 Di-hydroxyvitamin Acute myeloid leukemia Aging 2551 ling 3443 D3 1860 5680 AKAP 6225 Anti-apoptosis 198 1p36 5075, 7307, 8042 Acute myeloid leukemias Akt 1981, 2197, 2514, Anti-cancer drugs 6263 1q21 7686 3110 3746, 3845, 4419, 4542, Antibody-mediated 4101 20q deletion 4150 Acute promyelocytic 5638, 5991, 6018, 6073, Anticancer drug 1193, 3' UTR 7472, 4537 leukemia (APL) 7779 6048 3p 1509 7146 Akt kinase 5420 Antimicrotubule agents 3p tumour suppressor Ad E4 function ALCL 4466, 5623 6123 gene 7573 7847 ALK 5623, 7386 Antioxidant 3906 3p21 3563 ADAMs 1594 Alkylating agent 6627 Antisense 6643, 8019 3p21.3 2713 Adapter 6382, 6448 Alkylation 3580 Antisense MEL-CAM 5' upstream region 5215 Adapter molecule 6291 ALL-1/MLL/HRX gene 4676 5' UTR 893, 7472 Adapter and 2900 Antitumor drug 1110 53BP2 2720 signal transduction Allelic imbalance 4424, AP-1 669, 2205, 2334, 5qNCA 6946 6270 6095, 7809 2336, 2347, 2390, 2401, 6-thioguanine 6181 Adapters 6270, 6273, Allelic losses 4586 2771, 3266, 3332, 5132, 6q 8042 6403 Alternative lengthening 7597, 7761, 8009 [131I]MIBG 7804 Adaptor protein 5373, of telomeres 3835 AP-1 proteins 634 6435 Alternative splicing 1015, AP-2 2570 Adaptor protein Grap2 2976, 5562 AP1 1135 a-lipoic acid 289 1703 Alternative transcripts Apaf-1 3449 aIIbb3 6291 Adaptor proteins 951, 4665 Apaf-1/Nod1/CED4 Aa subunit 10 6372 Alu-PCR 6233 family 6473 Ab subunit 1892 Adenocarcinoma 5093, Amifostine 3533 APC 3528, 6871 AATYK 1015 7710 AML 8236 APL 3116, 5726, 7161, Abasic sites 7945 Adenomatous polyposis AML1 (RUNX-1) 6225 7204, 7216, 7274, 7287 Abelson 7744 coli (APC) 451, AML1 5660 APL blasts 7154 Abelson murine leukemia 6250 AML1/MDS1/EVI1 8236 Apo2L 1010 virus 4926 Adenomatous polyposis Amphiphysin IIb-1 6689 Apoptosis 16, 167, 147, Aberrant transcription coli 4884 4019 260, 303, 358, 430, 461, factors 5747 Adenomatous polyposis Ampli®cation 2023, 514, 571, 659, 677, 704, AC133 8249 coli tumour-suppressor 4853 812, 879, 910, 1010, Acetyltransferase 2988 protein 5920 Anagen 7536 1022, 1063, 1193, 1212, Acidosis 3751 Adenovirus 2281, 4466, Anaplastic carcinoma 1246, 1254, 1343, 1465, Actin 5359, 5366, 6435, 4793, 5279, 7824, 7836, 3235 1476, 1497, 1860, 1913, 6973 7855, 8270 Anaplastic large cell 1939, 1981, 2144, 2178, Actin cytoskeleton 3457, Adenovirus E1A 6828 lymphoma (ALCL) 2190, 2243, 2254, 2314, 3995, 6418 Adenylate kinase 6891 590, 7386 2378, 2390, 2537, 2713, Actin ®lament Adhesion 759, 997, 1739, Anchorage-independent 2720, 2737, 2749, 2805, reorganization 8175 4554, 7318 growth 2254, 5087 2814, 2826, 2836, 2877, Actin ®laments 6607 Adhesion molecule 4519 Androgen 2791, 7597 2908, 2927, 2937, 2982, Actinomycin D 2243, Adrenomedullin 2937 Androgen signaling 3880 3193, 3266, 3354, 3420, 3306 Adriamycin 113, 1076 Androgen-independent 3449, 3506, 3580, 3597, Activation domain 4161 Adult T-cell leukemia/ 6718 3620, 3597, 3620, 3629, Activation function-2 lymphoma 3301 Androgens 1455, 7965 3703, 3726, 3746, 3757, (AF-2) 77 AF4 gene 2900 270, 1403, 3888, 3929, 4050, 4070, Activation loop 8075 AF10 3281 1556, 2655, 2791, 3363, 4085, 4101, 4128, 4198, Activin 704, 5409 AFAP-110 6435, 6607 3751, 3959, 4188, 4685, 4235, 4258, 4305, 4317, Acute leukemia 3281, AFP (Alpha-fetoprotein) 7293, 8288, 8326, 8334 4365, 4476, 4507, 4542, 5718 869 Angiotensin II 1556 4591, 4601, 4710, 4757, Volume 20 keyword index

8379 4768, 4777, 4807, 4817, b-catenin 252, 395, 450, BMP 4383 c-erbB2 (neu) 2101 4891, 4925, 4995, 5043, 3247, 4249, 5093, 5972, BMP-6 7761 c-FLIP-s 4601 5087, 5124, 5225, 5341, 6250, 6871, 7812 BNP1350 5249 c-Fos 942, 1357, 7563 5595, 5718, 5779, 5789, b-galactosidase 7096 Bodily ¯uids 5195 c-H-ras 3683 5799, 5826, 5836, 5846, b2-microglobulin 7006 Bone biology 2401 c-Jun 1816, 2490 5865, 5982, 5991, 6026, B cell di€erentiation 3226 Bone resorption inhibitor c-Jun transcription 6073, 6084, 6111, 6172, B-cell ontogeny 3969 2068 factor ± phosphoryl- 6473, 6493, 6503, 6731, B-Myb 1425, 3376 BPOZ 4457 ation sites 7425 6752, 6764, 6805, 6910, Ba/F3 849 Brain 1015, 1022, 4128 c-Kit 5054, 6752 6973, 6983, 6994, 7006, BAD 4507 Brain lesions 692 c-Kit mutation 4528 7029, 7128, 7136, 7146, BAG-1 4095 Brain tumors 5378 c-Myb 759, 1688, 1784, 7250, 7257, 7334, 7352, Bak 7668 Branching 3258, 3746, 4554, 5595, 7334, 7352, 7386, 7478, Barrett's esophagus 7987 morphogenesis 3845 6084, 6205, 6983, 7514 7579, 7668, 7761, 7779, Basal cell carcinoma 198 Brca2 3937 c- 1176, 2814, 4542, 7836, 7855, 7836, 7855, Basic helix ± loop ± helix BRCA1 440, 5331, 6597 6544 7925, 7965, 7992, 8009, (bHLH) 1771, 8290, Brca11700T 2544 c-neu transgenic mice 8136, 8175, 8203, 8215, 8342 BRCA1 77, 4433, 4596, 6009 8258 Basic helix ± loop ± helix 4640, 4827, 6123, 7110, c-Rel 7098 Apoptosis susceptibility factors 4750 7514, 8215 c-Src 1816 3609 Bax 1852, 1939, 2805, BRCA1/BRCA1a/1b C-terminal domain 5493 ARE 4344 4476, 5249, 7464 1357 C-terminal SH3 domain ARF 1033, 4951, 7447 Bax conformational BRCA2 336 951 Arp2/3 complex 6418 change 7779 BrdU 2010, 3486 C/EBP 1730 Arsenic 7136 Bax expression and Breakpoint cloning 4249 C/EBPb 2301 2+ Arsenic trioxide (AS2O3) translocation 4817 Breast 6881 Ca 6372 7146 Bcl-2 240, 1176, 7342 Breast cancer 77, 440, Cadherin 3323, 4942 Arsenite 3585 Bc1-2 4807, 5789, 6026 514, 1246, 1287, 1300, CAG/CTG repeat Asbestos 7301 Bc1-2 family 5846 1357, 1465, 1509, 1688, expansion 5548 Astrocytes 7976 BCC 7770 1715, 2101, 2325, 2499, Calcium-binding protein Astrocytoma 7976, 8281 BCCIP 336 2771, 2791, 3247, 3301, 336 ASY 3929 Bcl-2 1476, 1939, 2122, 3348, 3428, 3497, 3506, Calpain 1287 Ataxia-telangiectasia 289, 2190, 2291, 2836, 2937, 3814, 4019, 4209, 4409, cAMP 8019 4409 3240, 3757, 3806, 4305, 4433, 4586, 4961, 4995, cAMP-dependent kinase Ataxia-telangiectasia 6172, 6983, 7098, 7128, 5093, 5420, 5511, 5810, 1186 ATM 4281 7579, 7597, 7836, 8258 6570, 6960, 7064, 7115, cAMP/PKA 4696 ATBF1 (AT motif Bcl-2 cleavage 4591 7408, 7551, 7753, 7925, Cancer 686, 748, 1128, binding factor 1) 869 Bcl-2 thapsigargin 933 8066, 8109, 8215 1497, 2611, 2805, 3116, ATF 2453, 7998 Bcl-XL 167, 2122, 4507, Breast cancer speci®c 3139, 3156, 3786, 3929, ATF2 1816, 8116 6983, 7668, 7925, 8281 gene 1 5173 5366, 5726, 5763, 6066, ATF3 1135 Bcl10 4317 Breast neoplasms 7318 6233, 6309, 6851, 7342, ATM 113, 278, 289, Bcr 1873 BRG1 3039 7820 3341, 4029, 5100, BCR/ABL 2636, 5826 Brn-3 4961 Cancer cells 1563 6095 Bcr ± Abl 1873, 5644, Brn-3a transcription Cancer frequency 4621 ATM/ATR 921 6188, 8236 factor 4899 Cancer ATP 7579 BER 581 Bromodomain 3076 8085 ATP-dependent bFGF 1913 Bronchial epithelial cells Cancer Genome chromatin remodeling BGP 219 634 Anatomy Project 4877 3047 BH3 proteins 5087 BS69 125 Cancer predisposition ATPase 2988 bHLH 8308 BTG1 2691 4621 ATPase/GTPases 6473 Bioinformatic 4581 Budding yeast 1128 Cancer risk 2264 ATRA 7161 Birt-Hogg-Dube Burkitt lymphoma 748, Cancer testis antigen Autocrine 1563, 8125 syndrome 5239 2171, 6084 7699 Autocrine Bladder 686 Butyrate 375, 3387 Capacitative Ca2+ entry 4019 Bladder cancer 531, 5005 Bystander 7085 933 Avian 4433 Bladder neoplasms 1042 Carbonic anhydrase II Avian retrovirus 1118 Bleomycin 5100 775, 3100 AXIN1 5062 BLM protein 8276 c-Abl 3845, 4298 Carcinogenesis 997, 1678, Axon guidance 3995 Bloom helicase 1143 c-Abl isoform 2618 2771, 3620, 5059, 5302, Bloom syndrome 1143, C-CAM 219 5341, 7761 8276 c-Cbl 1739, 7326 Carcinoma in situ 5155, b-arrestin 1532 Bmi-1 2171 c-Crk 6348 5897, 6538

Oncogene Volume 20 keyword index

8380 Cardiac 1626 CDK2 3173, 6851 Cell proliferation 3857, Chromosomal instability Cardiomyocyte 1626 Cdk6 2000 4696, 6315 1143, 3301, 3835, 4871 Cas 6057, 6448 cdk8 551 Cell proliferation, Chromosomal local- Casein kinase 2 1784, CDKN2D 7787 di€erentiation and ization 5067, 5920 2010 Cdks 4354 apoptosis 4877 Chromosomal trans- Casein kinase II 3247, CDKs 8317 Cell signaling 1318, 4209, location 48, 4412, 5951 CDNA array 2537, 2826, 5511 5580, 5718, 5755, 5763 Caspase 10 4424 6700 Cell spreading 5908 Chromosomal trans- Caspase 167, 358, 571, cDNA chip technology Cell stress 7992 location t(4;11) 2900 1193, 1203, 1476, 1852, 4402 Cell survival 5680 3979 2122, 2877, 2918, 3354, cDNA microarray 3674 Cell transfection 2655 Chromosome 1 7307 3726, 4070, 6111 cDNA microarrays 1300 Cell transformation 1135, Chromosome 10 5378 Caspase 3 4629 Cds1 7453 1229, 5493, 6559, 7486, Chromosome 10p 828 Caspase 8 3629, 4424, Cdx1 4180 7908 Chromosome 10p15 314 6910 CDX2 4884 Cell ± cell adhesion 4676 Chromosome 11p15.5 Caspase-2 isoforms 260 CEA 219 Cellular growth 7992 8154 Caspase-3 1254, 2749, CEACAM1 219 Cellular localization 2587 5562 5982 CEF 5118 Cellular senescence 2264 5005, Caspase-7 8258 CEF-4/9E3 chemokine Cellular transformation 5232 Caspase-8 2190, 5865, 2301 3651, 5350 Chromosome 18q 2273 6764 Cell adhesion 490, 899, Centrosome duplication Chromosome 19 2186 Caspase-9 5991 1425 3173, 6851 Chromosome 2q 4424 Caspases 1063, 4085, Cell adhesion molecule Centrosomes 7888 Chromosome 3 4249 4198, 4817, 4935, 6026, 609 Ceramidase 6493 Chromosome 3p 6820 6570, 7006 Cell cycle 69, 147, 543, Ceramide 1368, 6493, Chromosome 3p22 5062 Catalytic domain 5562 1094, 1128, 1164, 1212, 6752 Chromosome 6p21.1 Catalytic site 6920 1246, 1343, 1379, 1497, Cerebellum 1022 7965 Catenin 3323, 4942 1678, 1803, 1832, 1839, Cervical cancer 4899, Chromosome 6q27 980 Cathepsin B 3665 1923, 1990, 2055, 2314, 5799 Chromosome 7 2844 Cathepsin-D 6920 2378, 2737, 2956, 2988, Cervical carcinoma 4665 Chromosome 8 5810 Cauda equina 5084 3128, 3134, 3258, 3428, CGA 6955 Chromosome 9q 531 Cbfa1 295 3497, 3585, 3766, 4115, 7899 Chromosome arm 15q Cbl 6382 4138, 4198, 4466, 4554, Checkpoint 1803, 7453 6245 CBP 3376, 6653 4629, 5341, 5941, 6111, Chemokines 800 Chromosome instability CBP interaction 7425 6164, 6331, 6524, 6794, Chemoprevention 7710 8092 CBP/p300 800, 7204 6828, 7987, 8025, 8045, Chemoprotection 6164 Chronic active hepatitis CC3 270 8167, 8288, 8317, 8326 Chemotaxis 2032 3674 CCN 5525 Cell cycle arrest 590, 659, Chemotherapeutic agent Chronic myelogenous Cd95 2186 1913, 3193, 4507, 5043, 4995 leukemia 1871, 6188 Cdc25 4542 Cell cycle checkpoint 921 Chemotherapeutics 2749 Chronic myeloid CD30 590 Cell cycle checkpoints Chemotherapy 859, 3387, leukemia 2636, 7744, CD36 3443 899, 5503, 5897 4324, 4817, 6164, 6910, 8249 CD44 3399 Cell cycle control 1085 7128, 7386, 7579, 7668 cIAPs 4317 CD66a 219 Cell cycle inhibitors 3541 Chicken 5118 CIITA 4219 CD95 1063, 1193, 2713, Cell cycle progression Chicken embryo Circadian rhythm 5718 4258, 4757, 6493 910, 4007 ®broblast 2671 Cisplatin 3580, 4591 Cd2+ 1307 Cell cycle regulation 5888 Chicken embryo Cisplatin resistance 6181 Cdc2 289, 1803, 5249 Cell death 2937, 6123, ®broblasts 1135, 2453 CK2 6994 CDC2 8045 7161, 7579 Chimeras 3519 CKI 1128, 2000 Cdc25 543, 4393 Cell di€erentiation 4696, Chk 2 5897 Class II tumor Cdc25C 1839, 5249 8326 Chk1 5249, 7453, 7753 suppressor gene 980 Cdc42 3457, 8057 Cell division 3541 Chk2 5100, 5503 Class switch CDC55 5279 Cell growth 1465, 7551 Choline kinase 1110 recombination 5580 CDCP1 4402 Cell 7624 Chromatin 2991, 3007, Clear cell sarcoma 6653 Cdk 1128, 1832, 3206, Cell line 6840 3014, 3028, 3039, 3055, Cleared fat pad 5459 3695, 6164 Cell lines 5025 3165 Cleavage 2918 cdk inhibition 6840 Cell localization 2691 Chromatin domain 3076 Clinical trials 7257 CDK inhibitors and Cell migration 346, 490, Chromatin inheritance Clonality 2235 normal breast cells 1152, 2626, 3845, 4007, 3156 Clustering 2225, 3449 8025 4209, 5511, 6617, 6315, Chromatin remodeling CML 704 cdk1 5818 6459, 7318 2991, 3134, 3086 Co-deletions 1103

Oncogene Volume 20 keyword index

8381 Co-repressor 8100 Cyclin D1 133, 1445, DCC 2273 DNA double-strand Coactivator 6638 2325, 3428, 3506, 3641, DCIS 3348 breaks repair 3609 Coactivators 3014, 3047 4728, 6742, 7514 DD ± PCR 4568 DNA end binding 2895 Cockayne's syndrome Cyclin D2 1094, 2055, DDB2 7041 DNA hypomethylation 5964 7352 De-ubiquitinating 6009 Coiled coil 599, 3824 Cyclin dependent kinase enzyme 3869 DNA loop domains 3086 COL1A1-PDGFB 2965 (CD) 4793 Death 2122 DNA methylation 3028, Colon cancer 133, 219, Cyclin dependent kinase Death receptors 571 3139, 3156, 3165, 5033, 3387, 4450, 4581, 4884, inhibitors 1085 Degradation 551 7408, 7505, 7787 5062, 5225, 7464 Cyclin E 3067, 3173, DEP-1 5219 DNA methyltransferase Colon cancer cells 7478 4115, 5111, 5264, 6794 Depurinating adducts 3139 Colon carcinoma 2600 Cyclin G1-disrupted 7945 DNA micro-array 141 Colorectal cancer 645, mouse 3290 Dermato®brosarcoma DNA microarray 2225, 5025, 6544, 6871, 7120, Cyclin G1 3290 protuberans 2965 2854, 3449, 4984, 8249 7734 Cyclin-dependent kinase Designer cytokine 972 DNA mismatch repair Colorectal carcinogenesis (CDK) 8025 Desmoglein 8125 619, 3590, 4640 6095 Cyclin-dependent kinase Desmoplasia 7437 DNA multiploidy 6095 Common low penetrance 2 1254, 5951 Detergent-insoluble DNA ploidy 4871 alleles 2161 Cyclin-dependent kinase fraction 3918 DNA polymerase b 6181 Comparative genetics 3311, 3786, 5888 Deubiquitinating enzyme DNA repair 581, 739, 3437 Cyclin-dependent kinase 5533 3076, 3486, 4373, 6805, Competition cDNA 6 2889 Development 2401, 8288, 7945, 8136, 8215 library screening 7710 Cyclin-dependent kinase 8290, 8299 DNA replication 1990, Complex splicing 5930 8184 Developmental cell fate 3086 Composite regulatory Cyclin-dependent kinase 5718 DNA replication ®delity elements 2438 inhibitors 5888, 7987 DH domain 8057 7635 Conditional K-Ras allele Cycline D3 2000 Didemnin B 4085 DNA superhelical 6551 Cyclins 1825, 4354, 4793, Dietary mutagen 6066 torsion 3076 Congenic mouse 5243 7987 Diethylnitrosamine 303 DNA synthesis 5264 Connexin 43 4138 Cyclo-oxygenase-2 4450 Di€erential display 231 DNA topoisomerase II Constitutive signalling Cycloheximide 2225, Di€erential gene 1990 1582 3306, 3757, 5118 expression 141, 1300 DNA vaccines 4497 Contact inhibition 2727, Cyclooxygenase 198, 450 Di€erentiation 24, 375, DNA viruses 7266 5143 Cytochrome c 167, 1476, 704, 962, 1015, 1220, DNA-binding 1900, 4750 Cooperation 1445 1939, 4085, 4757, 7668 1343, 2281, 2413, 2559, DNA-damage 859, 6026 Core 2606, 5836 Cytogenetics 5763 2570, 3116, 3128, 5302, DNA-PK 739 Corepressor 125, 3100, Cytokine independence 5440, 5680, 6524, 6679, DOC-2/hDab-2 6960 7204, 8342 4354 7136, 7140, 7146, 7154, Dominance 501 COX-2 819, 3921, 5164, Cytokine receptor chain 7178, 7186, 7257, 7420, Dominant negative 4884, 6864, 7368 6660 7998, 8236, 8290, 8288 CpG island 3563 Cytokines 1900, 2197, Di€erentiation therapy Dominant-negative 2010 Cre-lox 6551 3703, 4128, 4198, 4235, 3110 Double strand break Cre/loxP 4344 6531 Di€use cancer 1525 repair 5572 CREB 1094, 2465, 5331, Cytoplasm 4298 Dimerization 599, 1229, Double strand breaks 7110 Cytoplasmic relocation 2365 4373 CRED 5164 4041 Diphosphorylation 8175 Double-strand breaks Crk 951, 6448 Cytoskeletal protein 58 Dlg 5431 (DSB) 2212 CRKL 6348 Cytoskeleton 2032, 2112, DNA binding 1784, 1882 Double-stranded RNA Cross-talk 1594, 7161 3217, 6403, 6459, 8057 DNA binding helix 1900 Crystal structure 8075 Cytosolic branched chain 1398 Downstream target Csk 5210 aminotransferase 2023 DNA chips 1379 2365 CUB domain 4402 DNA damage 769, 921, Doxorubicin 2720 Curcumin 7597 1076, 1212, 1803, 1923, Doxorubicin resistance CWR22 6718 Damage-speci®c DNA 2144, 2544, 2683, 2859, 1300 Cyclic AMP 7161 binding protein 7041 2932, 3486, 3766, 4050, Drosophila 2347, 8299 Cyclin 1085, 1128, 1803, DAP-kinase 1765 5043, 5449, 5503, 5826, Drug resistance 2749 3311 Daunorubucin 6752 5964, 6777, 7453, Drug screening 6871 Cyclin A 3067, 3376 Daxx 1, 7234 DNA demethylation 24, Drugs 1063, 5865 Cyclin B 5249, 5818 DBCCR1 531, 2956 5173 dsRNA 385 Cyclin C 551 Dbl exchange factor 7307 DNA double-strand DT40 1143, 4433 Cyclin D 6794 Dbl family proteins 1547 breaks 739, 2859 Dukes stage 5215

Oncogene Volume 20 keyword index

8382 E-cadherin 133, 1525, Endoplasmic reticulum (ER) FEZ1 4169 3814, 8125 1939, 3929, 5366 77, 8215 FGF 1669, 2655, 4613 E-proteins 8308 Endoplasmic reticulum Estrogen receptor 1715, FGF receptor 2 5878 E1A 2453, 7824, 7836, stress 2178 3497, 5420 FGF receptor 2655 8270 Endothelial 8334 FGF-2 7658 E1B 7836 Endothelial cells 1403, 8109 FGF-8 isoforms 2791 E1B55k/E4 34k 3519 1570 FGF-BP 1730 E2A 3897 -1 7505 8109 FGF2 1403 E2A-Pbx1 5708 Endothelium 2655 Etoposide 2918, 4817 FGFR3 686 1379, 1882, 2055, Endotoxin 2618 ets transcription factors FGFR3 4416, 5059 4115, 4740, 6152 Enhanced transactivation 1235 FGFR3 mutations 3553 E2F-1 910, 2671, 6983 501, 3409 Ets 8317 Fhit 3235 1033, 1678, 5341, Enhancer 1235 Ets2 1832 FHIT 4665 7073 ENL 411, 4853 ETV6 3437 FHIT gene 1798 E2Fs 6828 EphA2 6503 Evolution 7447 Fibroblast 5143 E4orf4 5279, 7855 Epidermis 2413, 7494 Ewing family tumors 626 E5 protein 7866 Epigenetic inactivation Ewing sarcoma 4365 5359 E6 5431, 7874 2186 Ewing tumour 3258 Fibroblast growth factor E6 oncogene 7430 Epigenetics 3055 Ewing's family tumors binding protein 7430 E6 protein 2134 Epithelial 8184 5747 Fibronectin 1739, 7976 E6/E7 oncogenes 8148 Epithelial cells 962, 2727, Ewing's sarcoma 626, Fine mapping 3979 E7 4740, 4768, 7677 5291 1010, 6653 FLIP 571, 5225 E7 oncogene 7430 Epithelial ovarian cancer EWS oncogene 1519 FLRG 5409 E7 oncoprotein 543 6617 EWS-ATF-1 6653 Fluorescent protein Early onset 7753 Epithelial-mesenchymal EWS-FLI-1 3258 tagging 3798 Early response gene 69 transition 788 EWS/ATF1 1756 Focal adhesion kinase Early-onset colorectal Epithelium 6309 EWS/ATF1 oncogene 951, 1152 cancer 4871 Epithelium to 4161 Follicular lymphoma EB1 3185 mesenchyme transition EWS/ETS 5747 7686 EBF3 3185 4942 EWS/FLI 626 Follistatin 5409 EBV 1176, 5313 Epitope mapping 2318 EWS/FLI1 1756, 6731 Fork head 5736 Ectodomain shedding Eps15 homology 6300 Exchange factor 188 Fos 2334, 2347, 2390, 1594 Epstein Barr virus 7029 Exchange factors 6372 2413, 2424, 2453, 2476, EGF 1388, 2606, 4019, ER-a 6965 Exon skipping 3969 7998 4281, 5199, 7954 ER-b 6965 exonuclease 7635 Fos proteins 2401 EGF receptor 1287, ER81 6215 Expression 1678, 5331, FRA3B 1798 1913, 2499, 2781, 3726 ErbB 1388 5913, 6587, 7110 Frabin 3457 EGFR 1594, 2314, 4019 ErbB receptors 34 Expression pro®le 2225 Fragile sites 1798 EGR2 4457 ErbB-2 3918 Expression pro®ling Friend erythroleukemia eIF2a 5836 ErbB-2/Neu 788 2704, 4228, 7437 2291 eIF3-p48 5291 erbB2 1445 Extracellular matrix 609, Friend virus 2946 eIF4E 726 ErbB2 5459, 7514, 7551 4710, 4995 FSH 4696 Elk-1 188, 1357, 5359 ERCC1 7694 Extramacrochaetae 8299 Fugu 5554 Elongin B 5067 ERK 106, 692, 1532, Fugu rubripes 3437, 7447 Elongin C 5067 2490, 3845, 3921, 5941, Functional yeast-based Embryo/cancer 7398 F-actin binding proteins assay system 6001 8085 Erk 6531 3735 Fusion protein 1756 Embryonal carcinoma ERK MAP kinases F-actin-binding activity Fusion proteins 5680 2559 4696 3457 FWT2 2050 Embryonic stem cell Erk1/2 2606 FABP 7413 Fyn 5210 2636 ERM 6309 FADD 1852, 2122, 7029 Emetine 3306 Erythroid enhancer 775 FAK 2626, 6459 EMT 2626 Erythroleukemia 2946, Familial ovarian cancer g irradiation 2186, 4601 End jointing- 3100, 5484 1318 g-interferon 2908 di€erentiation 4373 Erythropoiesis 3651 Farber disease 6493 g-ray radiation 5243 Endocrine therapy 6955 6643 Farnesyltransferase 358 G protein 1607, 1615, 1643 Endocytosis 2761 ES cells 1425, 2144, 4344 Fas (CD95/APO-1) 6632 G protein alpha subunit Endodermal sinus tumor Esophagus 7368 Fas 5789, 6764 1601 8042 EST 4581 FCGR2B 7686 G protein coupled Endometrial cancer 3428, Estradiol-3,4-quinone Fetoprotein transcription receptors 1540, 1570, 6965 7945 (FTF) 6811 1661

Oncogene Volume 20 keyword index

8383 G proteins 1530, 1563, Gene trap 6233 Green ¯uorescent protein Hemangioma 2655 1570, 1661 Genes 4568 (GFP) 4650 Hematopoiesis 4198, G-protein 1635 Genetic alterations 5025 GRF 2091 7420 G-protein coupled Genetic anticipation 5548 Growth 1186 Hematopoietic 5373 receptor 5903 Genetic mapping 5243 Growth arrest 4891, 5124 Hepatectomy 5264 G0 3067 Genetic variation 3597 Growth control 2889 Hepatic leukemia factor G1 arrest 3806 Genetic variation in Growth factor 1669 5718 G1 cell cycle arrest 2927 DNA-PKcs 3609 Hepatitis B virus 16, G1 phase 4728 Genetics 7085 5059, 7866 3674, 6233, 6579 G1 progression 1771 Genome scanning 5033 Growth factors 3746, Hepatocarcinogenesis G2 3486 Genomic ampli®cation 6018 4568, 5015 G2 checkpoint 4393, 1300 Growth in low serum Hepatocellular carci- 6103 Genomic footprints 2465 2254 noma 2704, 5232, G2/M arrest 3290, 6123 Genomic instability 4409 Growth inhibition 471, 6233, 7104 G3BP 3869 Genomic organization 1860, 4337, 6132, 6258, Hepatocyte growth G2 4891 5067, 5930 6516, 6820 factor 1318, 2761 Gz signal transduction Genomic sequence 8154 Growth regulation 8203 Hepatocyte growth 1615 Genomic structure 7051 Growth suppression factor-like protein Gab proteins 2197 Genotype-phenotype 1357, 3568, 4235, 5466 6142 Gab1 156, 1052 correlation 2544 GRP 2091 Hepatocytes 5132 GADD153/CHOP 2178 Geranylgeranyltrans- GSK-3 133 HER-1 5199 GADD45 2683 ferase 358 GSK-3b 252, 3786 Her-2 147 gadd45 7375 Germ cell tumor 8042 GTPase 6300 HER-2 5199, 6960 GADD45 6123 Germinal center 5580 GTPases 1530 HER-2/HER-3 hetero- GADD45a 3585 Germline mutation 2976, Gut-enriched KruÈ ppel- dimers 5199 Gads 1203, 6284 5084, 5543 like factor 4884 HER-3 5199 Gag-Myc 1118 Germline TP53 HER2 2101, 8258 Gain of function 4891 mutations 4621 HER2-ECD 2101 Galectin-1 7486 Glioblastoma 3665, 6938, H-ras mutation in HER2/neu 1465 Galpha12 5903 7021, 7976 SENCAR mouse skin HER2/neu 3695 Ganglia 3217 Glioblastoma multiforme 7945 HER2/Neu 6215 Gap junction 4138 (GBM) 6864 H-ras oncogene 16 Hereditary breast cancer GAS41 4853 Glioblastoma multiforme H-ras 1486 2544 Gastric cancer 329, 1235, 4107 hH-Rev107 5155 Heregulin 1465, 3918, 1525, 2101, 8009 Glioma 420, 1368, 2826, Ha-ras oncogene 1973 5199, 8258 Gastric carcinoma 5525 4757, 4853, 5401, 5789, Ha-Ras 6263 Heregulin-b1 8066 Gastric neoplasia 329 6669, 7398, 7976 Ha-ras 7812 Herpes 800 7021 Glucocorticoid 4324 Hairy 8342 Herstatin 5199 Gastrointestonal Stromal Half-life 3306 Heterochromatin 3128 Tumors (GIST) 5054 3039 Hamster 24 Heterozygosity 3580 GATA-sites 775 Glutaminolysis 6891 hARE 3906 Hexadecylphosphoryl- GDEPT 7797 Glycogen synthase kinase HBV 4568 choline 1110 GDNF 1929 3786 HBV enhancer 6811 hEXO1 3590 Gem 3217 Glycolipid-enriched HBx 3620 HFV 7274 Gene chip 4324 membrane domains HC11 mammary cells HGF 156, 7610, 8125 Gene cloning 5378, 5562 (GEMs) 6273 5459 HGF receptor 7610 Gene expression 2205, Glycolysis 6891 HCC 2606, 3323, 4568 HIF-1 4718 4484, 5595, 6196, 6679, Glypicans 7408 HCV 2606, 5836 HIF-1a 395, 5067, 5779 7051, 7524, 7710 GM ± CSF 972 HDAC 3067, 6152, 7204 High mobility group Gene fusion 48 gp 130 3464 HDAC inhibitors 3116 proteins 4537 Gene overexpression GPCR 1532, 1594 HDAC1 6039 High-density microarray 7021 GPCRs 5903 HDAC3 3716 analysis 6617 Gene regulation 430, GPVI 6291 HDM 1076 HIPK2 6132 3322 Gq 1626 HDM2 6784 Histone 3039 Gene targeting 320 GR D-loop mutation Head and neck cancer Histone acetylation 3007, Gene therapy 1825, 2826, 2465 6820 3156, 7787 4337, 7797, 7804 Granulocyte 7178 Head and neck tissues Histone acetyltransferase Gene transcription 6215 Granulopoiesis 7154 5302 404, 2991, 3047 Gene transfer 5865 Grb10 3959 Heart failure 1626 Histone code 3076 Gene transfer assays Grb2 1052, 6322 Heat shock 4095 Histone deacetylase 2991, 1547 Grb7 6315 Helix ± loop ± helix 8288 3100, 3128, 3165

Oncogene Volume 20 keyword index

8384 Histone deacetylases Human general Id2 8326 Insertional mutagenesis 3110 transcription factors IEX-1 7992 6233 Histone deacetylation 4877 IFN-g 4219 252 inhibitors 1860 Human Herpes Virus IGF receptor 4029 substrate Histone H3 3021 Type 8 7029 IGF-1 252, 1913 7318, 7542 Histone H3 kinase 726 Human herpesvirus 8 IGF-1R 8203 Insulin-like growth factor Histone methylation 3007 3311 IGF-I, insulin-like 4942 Histone phosphorylation Human lung cancer 4228 growth factor-I 4842 Insulin-like growth 3007 Human mammary IGF-II, insulin-like factors 4029, 7318 Histone ubiquitination epithelial cells 2771 growth factor-II 4842 int-2 7645 3007 Human mesothelioma IGF-IR 3857 Int6 5291 Histones 3014 cell lines 1085 IGF-IR, insulin-like 759, 4995, 5908, Histopathology 7104 Human papilloma virus growth factor-1 7398 HIV-1 RT 7635 (HPV) 4740 receptor 4842 Integrin a5b1 7976 HLH 8299 Human papilloma virus IGF2R 8042 Integrin linked kinase HMGA 4537 4899 IGFBP 3497 7064 HMGI(Y) 6132 Human papillomavirus IKK 385, 4728 Integrin signaling 6459 hMLH1 2976 (HPV) 7677 IKKg 2514 Integrin-linked kinase hMLH1 329, 3590 Human papillomavirus IL-10 cytokine family (ILK) 6250 hMLH1 gene 7120 3629 7051 2032 HNF1 (hepatocyte Human papillomavirus IL-13 6660 Integrins 346, 4710 nuclear factor 1) 869 type 16 543 IL-3 4476, 7779 Inter-leukin-1 6482 HNPCC 3590, 5215, Human Papillomavirus IL-4 6660 Interacting protein 4926 6241 type 16 8148 IL-6 3464, 4519, 5991 Interaction 4750, 8276 HNPCC syndrome 2976 Human polyomavirus ILK 6960, 7064 Interferon 800, 7326 Homeodomain 1329 4864 Immediate early gene Interferon-g 849, 6930 Homologous recombina- Human pre-implantation 7992 Interferon-inducible p202 tion 2212, 5572, 6627 embryo 8085 Immortal 278 6828 Homozygous deletion Human prostate cancer Immortal MEF 3306 -3 2636 4249, 5075, 5232 cell line 8036 Immortalization 2671, Interleukin-6 198, 677, -independence Human testicular germ 5118, 6679, 8036 972, 5799 2791 cell tumours 5548 Immortalized Atm null Internal initiation 893 Hormone-refractory Human tumor 3341 cells 4291 Internal ribosome entry 6718 Human tumors 739 Immune response 2465, 4095 HoxA9 874 Human wig-1 5466 4497 Internalization 1532 Hox cofactor 5708 Humoral immune Immunocytochemistry Intestinal epithelial cells HoxB8 5440 response 4107 8019 812, 4180 HPK1 1703 Hyaluronic acid 3399 Immuno¯uorescence Intestinal polyposis hPMS2 3590 Hybridoma 1398 5913 6250 HPV 5431, 7874 Hydrogen peroxide 4591 Immunogenicity 7478 Intragenic deletion 2976 HPV16 7430 Hypermethylation 329, Immunohistochemistry Intrinsic death pathway HPV16 E6 3519 3814, 4586 2579, 6538 5043 HSP70 7478 Hyperplasia 6538 Immunotherapy 4128 Intron 440 HTERT 2600 Hyperploidy 420 Imprinting 1246 Invasion 2781, 3665, hTERT 278, 828, 7797 Hypertrophy 1626 IMT 5623 4188, 4228, 6418, 6669, HTLV-1 1094 Hypoxia 2937, 4718, in situ hybridization 6938, 8066 HTLV-2 4484 5779 5810, 6538, 7770 Invasive carcinoma 6538 HTLV-I 2055, 2514 Hypoxia inducible factor In situ PCR 2579 Invasive growth 156 hTR 7797 1 1556 In situ RT ± PCR 2579 Invasiveness 5493 hTR mutants 714 Hypoxia inducible factor In vitro transcription Ionizing radiation 113, hTR promoter 7804 1435 3047 167, 278, 989, 3266, Human bronchial In vivo footprinting 6811 4291, 4298, 4373, 7085, epithelial cells 7301 Indirubin 3786 8092 Human cancer 10, IkB 8142 Indole-3-Carbinol (I3C) IQ domain 1756 7917 IkB-a 1287 2927 Iran 7368 Human chromosome 3 IkBa 3888 In¯ammation 4228, 7085 IRES 893, 2664, 4095, 1798 IkBb 2254 Inhibitors 5964, 6660 4270 Human chromsome 8p ICF syndrome 3139 INK4A 7447 IRF 4219 4169 ICP0 7266 INK4A 1103 IRF-3 800 Human developmental Id 8288, 8290, 8308, INK4B 7447 Iron 4718 genes 8085 8317, 8334 INrf2 3906 IRS-1 209, 3857

Oncogene Volume 20 keyword index

8385 IRS-1, insulin receptor Laloo 5210 LXCXE 6152 Matrix metallo- substrate-1 4842 LAPSER1 6707 Lycopene 3428 proteinase-2 3363 Isopeptidase 5538 Large T antigen (TAg) Lymphocyte 1164, 6225 Matrix metallo- Isozymes 6339 4793 Lymphoma 240, 2737, proteinases-2 6669 Laser capture 3226, 5595, 7029 Maturation 7161 microdissection 1981, Lymphomagenesis 5258, Max 1688, 2908, 4629, JAK 2499 6196 5580 4650 Jak2 2186 Laser microdissection Lysophosphatidic acid MCF-7 6794 Jak2 6188 4402 1540 MCF-7 cells 2749 JAK2 7925 LAT 6273, 6284 LZTS1 4169, 6707 MCF7 4961 JCV 4864 Lats1 tumor suppressor Mcl-1 198, 677, 704, jmjC domain 6946 6516 5799 JNK 367, 989, 1532, Leptomycin B 1307, 7588 M2-PK 6891 MCT-1 expression 1703, 2347, 2424, 2490, 2365 Macrophage 7085, 7096 6777 3266, 3341, 3443, 3585, Leukaemia 4412, 4817, Mad 1164, 2908, 7494, MDCK epithelial cells 4365, 6597 5763 8100 788 JPX-9 4484 Leukemia 404, 411, 3897, Mad Mxil 4650 Mdm-2 395 Jun 1135, 2205, 2334, 4324, 5644, 5660, 5695, MAD1L1 3301 Mdm2 1033 2347, 2390, 2413, 2453, 6946, 7006, 7136, 7420 Maf 2453 MDM2 2171, 3206, 4041, 2476, 3322, 7998 Leukemogenesis 88, 849 MAGI-1 5431 4951, 5856 jun oncogene 7524 Li-Fraumeni 2647 Malignant melanoma Mdm2 4576, 4972 Jun proteins 2401 Li-Fraumeni syndrome 3399 Mdmx 4576 JunD 2424, 5132 1076 Malignant mesothelioma MDR 303 Jurkat 2713 Li ± Fraumeni syndrome 4249, 6245 MeCP2 3165 4441 Malignant Medullary thyroid LIM domain 2844 transformation 1414, carcinoma 7809 k-ras 1765 Linkage analysis 5239 7098 Medulloblastoma 3857, K-ras 2144 Linkage disequilibrium Malignant transforming 4864, 5033 Kaposi's sarcoma 3311 5393 activity 1176 MEF2A 5359 Kaposi's sarcoma- Liver 3028 Malolactomycin D 6724 Meiosis 3021 associated herpesvirus Liver cancer 3674, 5111, Mammalian cells 6627 Meiotic maturation 933 523 6579 Mammary 2264, 5366, Meis1 874 KDR 3959 Liver regeneration 1825, 7710 MEK 692, 4209, 7588 kelch 5366 5264 Mammary carcinoma Melanogenesis 7536 Keratinocyte 7494 LMP-1 5313 cells 1388 Melanoma 972, 2243, Keratinocytes 471, 6660 Location 6339 Mammary epithelial cells 2814, 3363, 4029, 4676, Ki-ras 2044 LOH 4910, 6245 7645 5543, 7375, 8125 KIAA1009 4853 LOH11CR2A 7753 Mammary epithelium Melanoma cells 4591 KIF1B gene 5075 Loss of heterozygosity 7064 Melanoma di€erentiation KILLER/DR5 4601 2273, 3814, 4150, 5232, Mammary gland 5093, associated gene-7 7051 Kinase activity 5493 5572, 7770 5291, 7115 MEN 2 2161, 7809 Kinase inhibitor 3786 LPS 2618 Mammary gland MEN1 gene 4917 Kinase signaling 6559 LUCA-15 2713 di€erentiation 2325 MEN1 4917 Kinases 1530 Lung adenocarcinoma Mammary gland tumor MEN2 1929 Kinesin superfamily 7699 2044 MEN2A 3986, 5350 5075 Lung and colon cancer Mammary oncogens Menin 4917 Kit 7536 1892 7645 Mesoderm 5210 Knock-out 1635 Lung cancer 1509, 2579, Mammary tumor 6009 Met 1318, 2761, 3845, Knockout 6930 2877, 4249, 5062, 6258, Mammary tumorigenesis 5493 KO mice 5726, 7216 8154 34, 7645 MET 3735 KruÈ ppel-like factor 4 Lung carcinomas 8148 Mammary tumors 3937 Metabolome 6891 4884 Lung epithelial tissue MAP kinase 147, 1540, Metal ions 367 Ku antigen 1990 6551 1556, 1964, 5420, 5908, Metastasis 270, 997, Ku autoantigen 6048 Lung neoplasms 7505 6215, 6660, 7542 1793, 2254, 2781, 3323, KU70 2212 Lung squamous cell MAP kinases 5562 3363, 4188, 4228, 4581, Ku70/80 heterodimer 739 carcinoma (LSCC) MAPK 1653, 3266, 4209, 6142, 6930 7699 7398, 7588, 759 Metastasis-inducing Lung tumor 3979 MAPkinase 6322 DNA 1793 lacI 619, 6066 Lung tumors 6551 MatrigelTM 5219 Methylation 531, 1509, lacZ 7096 Lung tumour 1678, Matrix metallo- 1525, 1765, 2844, 3100, L1210 3354 6587 proteinase-1 6215 3128, 3348, 3528, 3563,

Oncogene Volume 20 keyword index

8386 5331, 5865, 6587, 7120, MMP-7 4007 Mutation 10, 88, 399, 3888, 4070, 4188, 4258, 7573 MMP-9 8066 686, 1005, 1525, 1892, 4365, 4519, 4917, 5132, MGMT 5258 MMTV 2264, 5093 3580, 3620, 4416, 5067, 6048, 7098, 7342, 7722, MGUS 5611 MMTV promoter 6009 5215, 5393, 7287, 7770 8009, 8142 MHC class II 4219 893 Mutation rate 7464 NF-kappaB 819 MIC-1 4007 MNU 5258, 6009 Mutational spectra 6066 NF-Y 5818 Mice 4219 Molecular cloning 5846 Mutations 4586, 6632 NF-YA 2683 Microarray 2781, 4484, Molecular diagnosis 48 Mya arenaria clam 748 NFkB 1276 6718, 7437 Molecular markers 1455 Myb 125 NGF 2570 Microarrays 6196 Monoclonal antibody Myc 1118 NHERF 6309 Microcell-mediated 1913, 3726 Myc 295, 1164, 3226, Nijmegen breakage chromosome transfer MORF 404 5341, 7494, 8116, 8270 syndrome 2859 314, 828 Morphogenesis 788 MYC 4984 Nitric oxide 1476, 6930, Microsatellite 6241 Morphology 1739, 3217 MycN 5913 7624 Microsatellite alteration Mos mutation 692 Myeloid 5440, 6983 Nitroreductase 7797 2235 Motility 7610 Myeloid leukemia 4150, NLS 2691, 6689 Microsatellite instability Mouse 3979 6205 nm23 6881 329, 1005, 4871 Mouse ®broblasts 538 Myeloma 5373, 5611 nmMHC 58 Microspikes 3457 Mouse hepatocarcino- MYND domain 125 Nocodazole 113 Microtubule 3185 genesis 7812 Myoblast 2691 NOD domain 6473 Microtubule bundle 3185 Mouse mammary tumor Myoblasts 7998 Nogo-B 3929 Microtubule inhibitor virus 3039 Myogenesis 1276 Non homologous 4373 420 Mouse model 2544, 5644 7998 Non-Hodgkin's Microtubule-associated Mouse model for breast Myosin II regulatory lymphoma 399 protein 3185 cancer 7645 light chain 8175 Non-homologous end Microtubule-interfering Mouse mutant 3937 MYST 404 joining 5572 agents 6597 Mouse thymic lymphoma Non-small cell lung Microtubules 899, 6172 5243 cancer 1765, 6551 Middle T-antigen 7908 Mouse thymic N-myc 2664 Non-steroidal anti- 97 lymphomas 2186 N-myristoylation 1643 in¯ammatory drugs Migration 6448, 7021, MOZ 404 N-CoR 3067, 3716 (NSAIDs) 6250 7398 MRIT 1010 N-oct3 7375 Non-steroidal anti- Minisatellites 2600 mRNA destabilization NADPH oxidase 1486, in¯ammatory drugs MIPP 5366 5118 6263 450, 6864 Mismatch repair 329, mRNA level 8109 ND10 7234 Nonmuscle cells 8175 538, 1923, 3580, 6066, MRNA levels 2527 Negative regulation 156, Noradrenaline trans- 7464 mRNA stability 4344 188 porter 7804 Mismatched hetero- MS-RDA 7505 Neomycin 4344 NOS-2 6531 duplex 7945 MSH2 4640 Neoplasia 3235, 3528 Notch 8342 Missense mutation 3568 MSH6 6241 Neoplasms 7368 NPM 7186 Mitochondria 167, 1063, MSI 6241 Neruro®bromatosis 97 NPM ± ALK 4466 1476, 2122, 4085, 4305, MSI tumors 7472 NES 1267, 2691 NPM ± ALK 5623 4807, 6073, 7128, 7779 mSin3 3716 neu 6960 NQO1 3906 Mitochondrial mutations MSP 3348 Neural crest 1329 Nrf2 3906 5195 MTG8 (ETO) 6225 Neuroblastoma 1307, NSAID 645, 4450 Mitogen 6309, 6920 mTOR 6172 3217, 4424, 5075, 7573, NSAIDs 819 Mitogen activation MUC1 4676 8326 NSCLC 3528, 6632 protein kinase 1981, Muc4 461 Neuroimmunology 4128 Nuclear bodies 1, 7234, 5359 Multidrug resistance Neuron 1015, 5124 7257 Mitogenic response 5511 1300, 6048, 7006 Neuronal 2664 Nuclear changes 260 Mitosis 2868, 3021, 3806 Multiple endocrine 1563 Nuclear exclusion 748 Mitotic checkpoint 3301 neoplasia 3986 NeuT 5459 Nuclear export 1267, 1839 MKK7 989 Multiple myeloma 3553, Neutral sphingomyeli- Nuclear factor kB 1715 Mlh1 619 4519, 5991 nase 1368 Nuclear factor of MLK-3 4484 Multiple oral lesion NF-kB 3585 activated T cells 2476 MLL fusion genes 3798 2235 NF-aB 4728 Nuclear factor-kB 4777 MLL 411, 5695 Mutagenesis 320, 6920 NF-bB 7597 Nuclear import 1839 MLL-CBP 375 Mutagenesis oxidative NF-kB 69, 385, 420, 571, Nuclear localization MMAC/PTEN 6669 stress 4291 669, 879, 1010, 1094, 5755, 8019 MMMT 6965 Mutant cells 2527 1287, 1900, 2055, 2178, Nuclear localization MMP 6724 Mutant 58, 4891 2465, 2514, 2805, 3247, signal 1435

Oncogene Volume 20 keyword index

8387 Nuclear matrix 5449 Ovarian surface epithelial p45SKP2 4768 Palmitoylation 1643 Nuclear protein 6946 cells 1318 p46ARF 5111 Pancreas 6930 Nuclear proteins 7624 Ovarian surface p48 7041 Pancreatic adenocarci- 3028 epithelium 5878 p53 147, 240, 289, 395, noma 4258 Nuclear receptors 3047, Overexpression 4586, 430, 501, 514, 581, 659, Pancreatic cancer 3751, 6638 7734 748, 769, 812, 899, 910, 7437, 8203 Nuclear translocation Oxidation 367 1212, 1368, 1398, 1669, Papillomavirus 3824 7588 289 1765, 1923, 2134, 2171, Papillomaviruses 7888 Nuclease 1852 Oxygen 7624 2291, 2527, 2544, 2559, PAR-1 1953 Nucleolar localization 2579, 2587, 2611, 2671, Paracrine 1563 signal 2551 2683, 2720, 2946, 2982, Paraganglioma 5084 Nucleolar protein 7524 p14ARF 1103, 6587 3173, 3193, 3206, 3290, Parotid gland 1445 Nucleolus 2171 p15INK4b 6587 3341, 3387, 3409, 3519, PARP-1 8136 Nucleoprotein complex p16INK4A 1103 3533, 3573, 3585, 3597, PATCHED 7770 architecture 2438 p16INK4a 6587 3620, 3766, 3806, 4050, PATF 5475 Nucleotide excision p53 1445, 7770 4441, 4576, 4601, 4613, Pathophysiology 4324 repair 563, 6026, 7694 5302 4629, 4951, 4972, 5100, Patient survival 4581 Nucleotides 6891 p107 1882, 4827 5225, 5258, 5449, 5466, Pax3 1 Nude mice 997 p130 1882, 4827 5484, 5503, 5779, 5818, Paxillin 6459, 7976 NuMA 4853 p130 protein 2889 5856, 6001, 6503, 6632, Pbx 5440 NuMA 7186 p14ARF 836, 7104 6653, 6784, 6805, 6851, Pc 4 3420 p14ARF 2171, 4586, 6994, 7073, 7104, 7250, PC12 2570 4972, 5543 7368, 7453, 7514, 7635, PCNA 484, 563 OCT4 8085 p15INK4b 6205 7836, 7888, 8136, 8276, PCR 6095 Oligoclonality 4910 p16 6103, 7301 8281 Pdcd4 231 Oligonucleotide micro- p16INK4a 5111, 5543, p53 conformation 2318 Pdcd4 669 arrays 2704 6731, 7104, 7787, 8317 p53 degradation 3519 PDGF receptor 3845 Onco-DNA 6811 P19 cells 1015 p53 induction 6864 PDGF-C 626 Oncogene 523, 1164, p19ARF 6731 p53 mouse model 320 PDT 2314 1530, 1607, 2153, 2334, p19INK4d 7787 p53 mRNA 3306, 5118 PDZ 6309 3475, 4917, 5059, 7420, p21 484, 1076, 1803, p53 mutants reactivation PDZ domains 7874 7563 3387, 3597, 3806, 4757, 3409 PEG-3 3266 Oncogene co-operation 4768, 6794 p53 mutation 4910 aptamers 6579 4951 P21 expression 2527 p53 protein 2889 Permeability transition Oncogene collaboration p21-null ®broblasts 561 p53 responsive elements 4085, 4305 295 p21waf1/cip1 563 3573 PEST motif 7563 Oncogene cooperation p21CIP/WAF1 4383 p53 status 8009 PFDN1 4853 cip1 7425 p21 1254 p53 toxic mutants 3409 PGE2 3921 Oncogenes 7115 p21WAF1/CIP1 5951 p53 tumor mutant 6001 Phaeochromocytoma Oncogenesis 2453, 4877, p21cip1/waf1 4007 p53 tumor suppressor 7573 4984, 5572, 7847 p21Cip1/Waf1 5484 gene 8193 PHD ®nger 4107 Oncogenic Ras 7486 p21Cip1 4354, 7301 p53-conformation 1307 Phenobarbital 7812 Oncogenic transforma- p21WAF1/CIF1 289, 1220 p53-DNA interaction Phenotypes 7287 tion 141, 2365, 8270 p21WAF1/CIP 962 2318 PHF3 4107 Oncoproteins 7677 p21Waf1 6524 p53-localization 1307 Philadelphia chromo- Oncostatin M 8193 p21WAF1 7722 p55Cdc 2537 some 6188 Oral cancer 24, 6196 p27 2814, 3641, 3695, p57 8184 Phosphatase 367, 5554 Orientation of 4138, 4554, 4629, 4768, p57KIP2 3258 Phosphatases 3949 heterodimer binding 4904, 5941, 6172 p63 3193, 4298, 4576, Phosphatidylinositol 2438 p27kip1 1254 5818, 6503 3-kinase (PI3K) 6018 Ornithine decarboxylase p27kip1 3428 p65 5132 Phosphatidylinositol 2908 p27Kip1 1688, 4354, 4466, p68 RNA helicase 7734 3-kinase 2197 Ornithine decarboxylase 7352 p73 514, 748, 769, 1669, Phospholipase 2781 antizyme 24 p27Kip1 6524 3193, 3519, 3568, 4050, 1110 Osteopontin promoter p300 1267, 4827 4298, 5111, 5818, 6503, Phosphorylation 1022, 1793 p34cdc2 2537 6689, 7293 1643, 1756, 1784, 2868, Osteosarcomas 3835 p38 2243, 2490, 3921, p97Eps8 106 3021, 3341, 3376, 4317, Ovarian cancer 1318, 5164, 6764 PAb1801 1307 5100, 5779, 6331, 6784, 5878, 6700, 7694, 7925 p38 Chk 3341 Paclitaxel 2720, 3806, 6851, 8075, 8116, 8142 Ovarian carcinoma 980, p38 MAPK 819, 1730 4995 Phosphotyrosine 5186, 7293, 7935 p43/p44 1556 Paired box 5736 6459

Oncogene Volume 20 keyword index

8388 Photodynamic therapy Polyamines 1715 Prostate 1152, 1455, Protein-protein inter- 3420, 4070 Polyclonal antibody 4107 2781, 3757, 5359, 7342, actions 3281 Photoreceptors 6742 Polycomb 3055 7597, 8184 Protein ± protein inter- Photosensitization 4070 Polycomb 411 Prostate adenocarcinoma action 1357 pHyde 5982 Polycomb group proteins 1455 Protein ± protein inter- Phyllotoxin 859 3798 Prostate cancer (PCa) actions 5913 Phylogeny 5846 Polycystic kidney disease 2927 Proteolysis 8142 PI 3-K/Akt 5799 5972 Prostate cancer 314, 490, Proto-oncogene 4270 PI 3-kinase 252, 2080 Polymorphisms 2161 1220, 1860, 2273, 3301, Proton pump inhibitors PI3 kinase 4180, 7551 Polyoma virus 4951 3880, 4169, 4188, 4497, 7987 PI3-K 209, 5941, 5991, Polyoma virus T-antigens 5195, 5401, 5903, 5982, PRUNE 6881 7352, 7542 4951 6073, 6707, 6718, 7965, PSA 997 PI3-K/Akt pathway 677 Polyomavirus 7917 8215 PSGR 5903 PI3-kinase 7610 Polyp 819 Prostate intraepithelial Psoriasis 7494 PI3-kinases 1186 Polyploidy 1825, 1923 neoplasia 5195 PTB 6322 PI3K 1653, 2514 Post-transcriptional con- Prostate speci®c antigen Pten 2186 PI3K, phosphatidylino- trol 1669 4497 PTEN 4457, 4466, 5554, sitol-3 kinase 4842 Postmenopausal breast Prostatic neoplasms 2836 6073, 7542 PI5K 2514 cancer 6955 Protease 2737 PU.1 6039 PIASy 8249 PP1 activity 3776 Protease-activated recep- Purkinje cells 1022 PIG8 7753 PP2A 10, 1892, 6057, tors 1570 Pyk2 2626 pin2/TRF1 1497 7855, 7908 Proteasome 551, 942, Pyropheophorbide 4070 PINK1 4457 pp32 2153 2761, 4740, 7257, 7563, PIP box 484 pp60v-srv 2301 7874 PKA inhibitor 6048 PPP2R1A 2050 Proteasome inhibition Quantitative real-time PKA RIIa 6225 PR 6965 4972 PCR 1103 PKC 156, 759, 4258, PR-B 6965 Protein binding modules Quantitative RT ± PCR 6339, 6752, 7398 pRb 6152, 6828 4058 8109 PKC delta 989 pRB dephosphorylation Protein degradation 942, Quiescence 3311 PKCi 6794 3776 7563 PKCg 5143 PRCC 178, 1414 Protein inhibitor of PKCs 1964 Pre-B cell acute lympho- activated STAT 3880 r-hu-IFNg 1085 PKI166 5459 blastic leukemia 5708 Protein interaction 7234 Rac 1607, 6973, 8057 PKR 385, 5836, 8045 Pre-mRNA splicing 178 Protein interactions 836, Rac1 6448 PLAG 4718 Precursor 8334 6315 RACK 6339 PLAGL 4718 Predisposition 8092 Protein kinase 5562 RAD51 2212, 6627 Plasma membrane 3949, Preneoplasia 3348 Protein kinase A 8019 RAD51B 2212 5420 Primary translocation Protein kinase C (PKC) RAD52 2212 Platelet 6291 5611 2868 RAD54 2212 Platelet-derived growth Primitive neuroecto- Protein kinase C 6764, Radiation 1388, 2190, factor receptor 3824 dermal tumor 5033 8258 2243, 2826, 3597, 7096 Platelets 1570, 6273 Pro-B cell 3969 Protein kinase C iota Radiation e€ects 4409 PLC-g1 7954 Progestin 34 4777 Radiation hybrid PLCg 6752 Prognosis 7104 Protein methylation 3014 mapping 2023 Pleckstrin homology Programmed cell death, Protein micoarrays 1981 Radioresistance 726 domain 106 69, 859, 1852, 6473, Protein phospatase 1 Radiosensitivity 4029 97, 5623 6570, 8281 6111 Raf 2606, 3949, 4354, PLZF 7186, 7204 Progression pathways Protein phosphatase 2A 4807 PMA 219 1973 2050, 5279 Raf1 4542 PML 1, 7204, 7234, 7243, Proliferation 1403, 2010, Protein phosphatase type RalA 1816 7250 2390, 2413, 3497, 4904, 1 3776 Ran 2618 PML isoforms 7223 7021, 7352, 8025, 8290 Protein phosphorylation Rap1A 7334 PML nuclear bodies 7266 Proliferation arrest 5475 1900, 6111, 6215 Rapamycin 6172 PML-RAR 3110 Proliferation competence Protein stability 1435 RAR/RXR heterodimers PML-RARa 7136, 7146 2000 Protein turnover 8116 3047 Pms2 619 Proline-rich domain 5449 Protein RARa gene Pnn 4007 Promoter 523, 1235, 3995 rearrangements 7154 Pocket protein 5533 4115, 4383, 6899, 7430, Protein tyrosine Ras 188, 252, 1276, 1540, Pocket proteins 7115 7722, 8167 phosphatase 5219 1607, 1661, 1816, 3949, POD 7204 Promyelocytic leukemia Protein-protein inter- 4180, 5264, 5826, 5908, Polyamides 3116 7140 action 346, 2068 6531, 6973, 7334

Oncogene Volume 20 keyword index

8389 Ras and GTP binding Renal cell carcinoma RhoB 6531 Ser phosphorylation 219, proteins 1186 1414, 2727, 3888, 5067, Ribonuclease 980 3464 Ras exchange 2091 5393 Ribosomal RNA Ser/Thr phosphorylation Ras localization 7486 Renal tumors 5239 processing 5951 156 Ras proteins 7624 Reovirus 6910 Ribozyme 2101, 6597 SERCA 933 Ras signaling 2378 Repair 2212 Ring ®nger domain 1267 SEREX 4107 Ras transformation 2854 Repeat 6241 RING ®nger proteins Serine dephosphorylation Ras V103E 2091 Repeated sequence 5215 2908 6057 Ras-responsive element Repetitive DNA RNA expression analysis Serine-threonine kinase 6724 sequences 1005 6617 6132 RasGRP 6284 Representational differ- RNA polymerase 2988 Serine/threonine kinase RASSF1 3563 ence analysis 2704, RNA polymerase II 5964 4419 Rat 6 58 4402 RNA splicing 885 Serotonin IB receptor Rat 7710 Repression 775, 1118 RNA structure 4613 7505 Rat embryo ®broblasts Repressor 440 RNA-protein inter- Serum 1730 7425 Resistance 5789 actions 4613 SH2 5186, 6322, 6348, Rb 3128, 3134, 3597, Resistance gene 3979 Rodent ®broblast 1176 6382 4138, 6164, 8100 ret 885 Ron 6142 SH2 domain 1203 RB 6742 Ret 209 ROS 1556 SH3 1052, 6348, 6382 RB 962, 4827, 7935 RET 7809 Roscovitine 3206 SH3 domain 1203, 5373, RB and retinoblastoma RET 1929, 2161, 3475, RP1 protein 5920 6689 7073 3986, 6973, 7536 RPA 1379 SH3 linker region 951 Rb protein 6840 RET tyrosine kinase RPB4 1519 SHC 1929 RB-2/p130 7935 receptor 5350 RPB7 1519 Shc 788, 2314, 3475, 6322 Rb2/p130 2570 ret/ptc 885 RRM1 8154 Shedding 3399 RBCC 7223 RET/PTC 3235 RRNA transcription SHIP 6322 RBCC 7274 Retina 5475, 6742 2551 SHP-2 6018 Rbx1 5067 Retinoblastoma 2918, Runt domain 295 SHP2 5991 Reacetylase methyltrans- 3428, 4827, 5111, 5533, RUNX 5660 Sialomucin complex 461 ferase 2988 5538, 6742, 7888, 8092 Runx2 295 Signal tranduction 7524 Reactive oxygen species RXR agonist 375 Signal transduction 490, 1368 (Rb) 4740 RXR signaling 7161 1152, 1276, 1486, 1530, Real-time PCR detection Retinoblastoma protein 1607, 1635, 1661, 2197, 8109 3776, 4793, 6111, 8326 2334, 2771, 3651, 4058, Real-time RT ± PCR Retinoblastoma protein S. cerevisiae 2091 4542, 5826, 6273, 6291, 4601 family 1343 S. pombe 6001 6315, 6331, 6403, 7658, Real-time RT ± PCR Retinoblastoma protein S100A4 4685 8203 quanti®cation 6955 phosphorylation 3311 S6K2 7658 Signal transduction Rearrangements 2600 Retinoic acid 2559, 3506, SAM domain 5373 pathways 7645 Receptor 1229, 6482 6820, 7136, 7140, 7186, Sarcoma 1756, 5763, Signaling 2205, 5313, 7413, 7935, 8025 6881 6018, 6482, 8066, 7274 3986 b SC-35 4650 Signalling pathways 7908 Receptors 1563 6820 Sca€old 1532, 6339 Signature patterns 6617 Recombination 2318 Retinoids 6638, 7154, Sca€old engineering 5186 Single chain antibody Redox control 3703 7178 Sca€old library 5186 (scFv) 7954 Redox state 4235 Retinol 7413 SCE 6627 Singlet oxygen 6764 Redox-control 2336 Retroviral tagging 295 SCF 3641 Ski/Sno 8100 Regulation 3751 Retrovirus 3226, 7744 Schwann cells 97 Skin 6103, 7761 Regulation of G2/M Rett Syndrome 3165 SCID 3235 Skin carcinogenesis 7041 6516 `Rexinoids' 7161 Scirrhous 5525 Skin chemical Regulation of gene RGK proteins 3217 SCLC 7658 carcinogenesis 471 expression 4877 Rhabdomyosarcoma 5736 SDHD 5084 Skin tumors 5239 Regulatory domain Rhesus macaques 4497 Secondary 8092 Skip 7677 5493 Rho 1540, 1661, 6973 Secondary translocation skp2 1825 Rel 7098 Rho GEFs 8057 5611 SLP-76 1052, 6284, Rel-homology domain Rho GTPase 6418, 7307 Senescence 278, 980, 6291 4917 Rho kinase 2112 3541, 5818, 7250, 8184, Smad 88, 2205, 3322, RelA 7722 Rho-kinase 2868 8317 4383, 5409 RelB 7722, 8142 Rho/Rac proteins 6372 Sensitivity 2877 Smad2 2273 Renal carcinoma cells RhoA 1953, 4007, 6531, Sepsis 2618 Smad4 2273 7610 8057 Septin gene 5930 Smad7 879

Oncogene Volume 20 keyword index

8390 Small cell lung cancer STAT5 2080, 6643 T-cell protein tyrosine TGF-b type II receptor 3563 Staurosporine 420, 1193, phosphatase 4728 1235 Smooth muscle cells 1688 2713, 3354, 6084 T-cell signaling 5920 TGFBR2 7464 Snail 3814 Ste20 kinase 6559 T-cells 1703 Therapy 4768, 5763, 6579 SNP 1476 Stem cell 2264 Tal-1 3897 Thrombin 1556, 1570, SNT/FRS2 1929 STI571 5054 Target gene 231, 7524 1953, 1964 SNW 7677 Stimulation of motility Target genes 2225, 2413, 2197 Socs1 849 4685 4984 Thrombospondin 3443 Soft agar 7413 Stk 6142 Target-genes 2390 Thrombospondin-1 7293 Soft tissue sarcoma 48 Stomach 1525 Targeted mutagenesis Thymic hyperplasia Soluble receptor 972 Stress 2336 4344 8148 Somatic activation 6551 Stroma 5525 Targeting 4101 Thymosin b-10 6700 Somatic hypermutation Stromelysin-1 3716 Tax 1094, 2055, 2514, Thyroid 599, 2161, 2281, 5580 Subtraction cloning 4484 6973, 7334 Somatic mutation 4596 4450 Taxol 113, 147, 2537, Thyroid carcinoma 885, Sos1 2091 Subtraction library 2281 4777 3235, 3475 Sp1 962 SUMO 1, 7223, 7257, Taxol1 5459 Thyroid cell 989 Sp1 7274 Tcf-4 1793 Thyroid di€erentiation 6899 SUMO-1 2587, 7266 TCLI 5638 1186 Sp1 transcriptional factor SUMO/Sentrin 7243 TCLIb 5638 Thyroid hormone 775 4281 Superoxide 1486 TEL 3716 TIMP-4 4337 Sp100 7234 Superoxide anion 6263 TEL-JAK2 2080 TNF 812 SP100 7243 Superoxide dismutase TEL-Jak2 849 TNF ligand family 4101 Spermatogenesis 1343, 430 Telomerase 2671, 3541, TNF receptor 590 5155, 5897 Suppression subtractive 714, 7797, 8036, 828 TNF receptor family Spheroids 7804 hybridization 2023 Telomerase activity 3835 3726 Sphingosine-1-phosphate Survival 1771, 2080, Telomerase maintenance TNF-a 1486, 7965 1540 2937, 4542 3835 TNFa 4365, 4519, 6084 Spi-1/PU.1 5484 Susceptibility gene 5243 Telomerase malfunction Topoisomerase I 836 Spindle assembly Susceptibility to 714 Tousled-like kinase 726 checkpoint 420 radiation lymphoma- Telomerase repressor TP53 2647, 8092 Spindle checkpoint 6994 genesis 3609 gene 828 TPA 1220 Splice variants 7223 SV40 7899 Telomeres 1497, 3541 TPA induction 523 Splicing 2647, 3683, 4041 SV40 large T 5449 Telomeric protein 1497 TPEN 1307 Splicing variants 4581, SV40 large T antigen Teratocarcinoma 2559 TPFI-2 6938 6689 2023, 6731 Teratocarcinoma cells TRADD 2826 Sporadic breast cancer SV40 polyomavirus 4441 2982 TRAF 6482 4596, 7110 SV40 small t-antigen TERE1 gene 1042 TRAF-2 4317 SPRR1 634 2325 Terminal cell TRAF2 2243 Squamous cell Swi/Snf 3039 di€erentiation 7051 TRAIL 1010, 1476, 2122, di€erentiation 634 SYK 3969 Terminal di€erentiation 2190, 2836, 3757, 3888, Src 759, 1152, 1601, Synovial sarcoma 3281 5124 4258, 5789, 6073, 6910, 2068, 2499, 5210, 6057, SYT 3281 Testicular germ cell 7029, 7128 6435, 6448, 6607, 6643 tumors 5155 TRAIL-receptor 1 399 Src family kinases 1465 Testicular germ-cell TRAIL-receptor 2 399 Src homology 3 6300 T and B lymphocytes tumours 5897 Trans-splicing 3683 Src kinases 1964, 4935 4935 Testis 4298 Transactivation 514, 581, Src-homology domains T antigen 7917 Tethering 2465 659, 1594, 2365, 2587, 6403 T cell receptor 1203, 6284 Tetracycline-regulated 8276 SRF 6638 T cell receptor signalling gene expression Transcript imaging 2854 SSA/Ro52 8154 6273 3695 Transcript map 8154 SSCP 5393 T cells 4412 Tetramerization 2611 Transcription 240, 800, Stability 910 T lymphocytes 1964 TFE3 178, 1414 1730, 1832, 1900, 2378, Stabilization 6777 t(11;16)(q23;p13) 375 TFIIF 4853 2991, 3007, 3028, 3055, Stable cell line 4961 t(15;17) cell lines 7287 TGFa 5409 3206, 3464, 4161, 4383, STAT 5 5826 t(4;14) 3553 TGF-b1 1254 4650, 5164, 5856, 6638, STAT 7186, 7326 t(X;1) 1414 TGF-B 2205 7110, 7342, 7420, 7824, STAT proteins 2499 T-ALI 4412 TGF-b 3332, 5888, 7976, 7965, 8167, 8342 Stat3 1601 T-antigen 4864 8025 Transcription activation STAT3 3464, 4528, 5350 T-cell leukemia 5638 TGF-beta receptor 5015 178 Stat3 7925 T-cell lymphoma 8136 TGFb receptors 6899 Transcription ETO 5660

Oncogene Volume 20 keyword index

8391 Transcription factor 859, Transforming growth Tumor prevention 645 3323, 3735, 3857, 6382, 2334, 2347, 3437, 4961, factor-beta 5015 Tumor progression 471, 6643 5475, 5736, 5755, 8299, Transgenic 619 1981, 2291 Tyrosine-kinase 6973 8342 Transgenic Drosophila Tumor promotion 7812 Tyrphostins 1388 Transcription factor AP- 6871 Tumor rejection 972 1 7524 Transgenic animals 2325 Tumor related gene Transcription factor CBF Transgenic mice 1287, 1042 Ubc9 7243 7120 1973, 2044, 3247, 3986, Tumor suppression 58, Ubiquitin 551, 3869, Transcription factor 5015, 5484, 5726, 5972, 3695, 6669 4972, 5533, 5538, 7243 cooperativity 2438 7064, 7096, 7216, 8148 Tumor suppressive e€ect Ubiquitin ± proteasome Transcription factor Transgenic mouse 1635 4138 pathway 7266 Oct-1 2683 Transient neonatal Tumor suppressor 10, Ubiquitin-proteasome Transcription factors diabetes 1246 141, 219, 1164, 1892, 5225 2805, 3116, 5680, 5726 Transitional cell 2050, 2727, 2859, 3716, Ubiquitin-proteasome Transcription regulation carcinoma 2956 4169, 5015, 5554, 6707, system 1435 1033 Translation 4095, 4270, 7888, 7899, 8100 Ubiquitination 1739, Transcription repression 7326 Tumor suppressor gene 3641, 4740, 6300, 6382 1882, 2178 Translation initiation 314, 2273, 3563, 4457, Ubiquitylation 1267, Transcription therapy 2664 5155, 5232, 5401, 5810, 7734 3116 Translational control 6245, 6258, 7115 Ubp 5533 Transcription-coupled 4613 Tumor suppressor gene UBX domain 48 DNA damage repair Translational regulation loci 5005 UCS15A 2068 4640 726, 4596 Tumor suppressor Ultraviolet 5856 Transcription-coupled Translesion synthesis proteins 7917 Ultraviolet 6805 repair 538 6181 Tumor supressor 6946 Unp 5538 Transcriptional Translocation 411, 5378, Tumor virus 7899 Unscheduled DNA activation 1519, 2134, 5572, 5660, 5736, 7686 Tumorigenesis 1445, synthesis 7041 4576 Translocations 2965 2401, 2791, 4337, 6142, Untransformed and Transcriptional activity Transmembrane 7866 7064, 7514, 8288 tumor-derived cells 3568, 4750 Transmembrane domain Tumorigenicity 2281, 5951 Transcriptional coactiv- 3824 4528, 7478 uPAR 1816 ator 2134 Transmembrane Tumors 4041 Upper and lower urinary Transcriptional down- topology 5313 Tumour 4416 trace 4910 regulation 4281 Transrepression 659 Tumour growth 4899 Urokinase 2032 Transcriptional factor TRIM 7223, 7274 Tumour suppressor 1033, Uroplakin 1973 7694 Trithorax 3055 1669, 5503, 6152, 7447 Urothelial carcinoma Transcriptional regul- Tropomyosin 2112 Tumour suppressor gene 1973, 4910 ation 440, 645, 769, TRRAP 8270 1509 UV 6103 2476, 3014, 3363, 3376, ts-p53 2225, 3449 Tumour suppressors UV light 5964, 6026 8193 TSC2 4904 7824 UV-damage 538, 6784 Transcriptional repres- TSG 2844 TUNEL 4629 UVB 3921, 5164, 7375 sion 4115, 4917, 5173, TSLC1 5401 Turcot 5215 UVC 7375 6039, 7274 TSLL1 5401 Two-hit hypothesis 3814 Transcriptional synergy TSLL2 5401 Two-hybrid system 8276 2438 TSU-Pr1 1220 Type I insulin-like V(D)J recombination Transduction 1186, 6660 Tuberin 4904 growth factor receptor 5580 Transformation 106, 599, Tuberous sclerosis 4904 34 V-ATPase 7866 669, 1601, 1607, 1953, Tubulin binding proteins Tyrosine 4161 v-Crk 5908, 6348 2153, 2514, 4180, 4419, 5920 Tyrosine kinase 209, 599, v-ErbA 775, 3100 5291, 5431, 6679, 6724, Tumor 484, 4101 1022, 6372, 7386, 7744, v-Fos 942 7301, 7307, 7820, 7824, Tumor angiogenesis 3443 8075 v-mos 8045 7847, 7874, 8167 Tumor antigen 7699 Tyrosine kinase v- oncogene 231 Transforming growth Tumor growth 461, 3703 inhibitors 2499 v-Rel 7098 factor 6840 Tumor initiation 4441 Tyrosine kinase substrate v-Src 5941 Transforming growth Tumor marker 6544 6418 Variant ALK fusions 5623 factor b 471 Tumor metamorphosers Tyrosine kinases 1229, Vascular endothelial Transforming growth 7216 6403, 7908 growth factor 198 factor-b 88 Tumor necrosis factor Tyrosine phosphatase Vav 6372 Transforming growth (TNF) 6482 609 Vav family 8057 factor-b (TGFb) Tumor necrosis factor-a Tyrosine phosphoryl- VEGF 1403, 3266, 3751, 6899 3629 ation 951, 1739, 2626, 5511, 7293

Oncogene Volume 20 keyword index

8392 VEGF receptor 3959 Virus replication 6579 wnt-1 7645 Yaf2 5913 Vertebrate genomes 3437 Viruses 7820 Wnt 5093 Yeast 501, 1519, 2336 Vesicle tracking 6418 Vitamin 4235 WNT 645 Yeast functional assay vGPCR 1582 Vitamin-A 3703 Wnt pathway 4864 3533, 3573 VHL 5067 vMIA 4305 Wound 7494 Yeast functional assays VHL 395, 2727 vMIA 7579 WRN 2551 3409 VHL gene 5393 Von hippel-lindau tumor wt p53 5951 Yeast two hybrid 3281, Vimentin 2868 suppressor 1435 WWOX/FOR gene 5232 4750 Vimentin-Ser72 kinase Vorozole 7710 Yeast two-hybrid 5913, 2868 6689 Vincristine 113 X gene 16 Yeast two-hybrid Viral 7TM 1582 Waf1 3173 X-RARg 7204 screening 6132 Viral chemokine WD40 repeat 5378 XAGE-1 7699 YXXQ motif 3464 receptors 1582 WEHI 231 7352 Xenopus laevis 933, 3766 Viral interferon WEHI 231 cells 1688 Xenopus 1329, 5210 regulatory factor 523 Werner syndrome 2551 Xenotransplanted tumor z-VAD 1852 Viral oncogene 3824, WI-38VA-13 cells 1486 461 ZAC 1246 7866 Wilms tumor 2050 Xeroderma pigmentosum Zac1 2134 Viral oncoproteins 7888 Wilms' tumor 4337 5964, 7041 Zinc ®nger 5466, 6946 vIRF-1 800 WISP1 5525 Xmeis1 1329

Oncogene