The Digestive Glands
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The Oesophagus Lined with Gastric Mucous Membrane by P
Thorax: first published as 10.1136/thx.8.2.87 on 1 June 1953. Downloaded from Thorax (1953), 8, 87. THE OESOPHAGUS LINED WITH GASTRIC MUCOUS MEMBRANE BY P. R. ALLISON AND A. S. JOHNSTONE Leeds (RECEIVED FOR PUBLICATION FEBRUARY 26, 1953) Peptic oesophagitis and peptic ulceration of the likely to find its way into the museum. The result squamous epithelium of the oesophagus are second- has been that pathologists have been describing ary to regurgitation of digestive juices, are most one thing and clinicians another, and they have commonly found in those patients where the com- had the same name. The clarification of this point petence ofthecardia has been lost through herniation has been so important, and the description of a of the stomach into the mediastinum, and have gastric ulcer in the oesophagus so confusing, that been aptly named by Barrett (1950) " reflux oeso- it would seem to be justifiable to refer to the latter phagitis." In the past there has been some dis- as Barrett's ulcer. The use of the eponym does not cussion about gastric heterotopia as a cause of imply agreement with Barrett's description of an peptic ulcer of the oesophagus, but this point was oesophagus lined with gastric mucous membrane as very largely settled when the term reflux oesophagitis " stomach." Such a usage merely replaces one was coined. It describes accurately in two words confusion by another. All would agree that the the pathology and aetiology of a condition which muscular tube extending from the pharynx down- is a common cause of digestive disorder. -
Salivary Gland Infections and Salivary Stones (Sialadentis and Sialithiasis)
Salivary Gland Infections and Salivary Stones (Sialadentis and Sialithiasis) What is Sialadenitis and Sialithiasis? Sialdenitis is an infection of the salivary glands that causes painful swelling of the glands that produce saliva, or spit. Bacterial infections, diabetes, tumors or stones in the salivary glands, and tooth problems (poor oral hygiene) may cause a salivary gland infection. The symptoms include pain, swelling, pus in the mouth, neck skin infection. These infections and affect the submandibular gland (below the jaw) or the parotid glands (in front of the ears). The symptoms can be minor and just be a small swelling after meals (symptoms tend to be worse after times of high saliva flow). Rarely, the swelling in the mouth will progress and can cut off your airway and cause you to stop breathing. What Causes Sialadenitis and Sialithiasis When the flow of saliva is blocked by a small stone (salilithiasis) in a salivary gland or when a person is dehydrated, bacteria can build up and cause an infection. A viral infection, such as the mumps, also can cause a salivary gland to get infected and swell. These infections can also be caused by a spread from rotten or decaying teeth. Sometimes there can be a buildup of calcium in the saliva ducts that form into stones. These can easily stop the flow of saliva and cause problems How are these infections and stones treated? Treatment depends on what caused your salivary gland infection. If the infection is caused by bacteria, your doctor may prescribe antibiotics. Home treatment such as drinking fluids, applying warm compresses, and sucking on lemon wedges or sour candy to increase saliva may help to clear the infection quicker. -
Head and Neck
DEFINITION OF ANATOMIC SITES WITHIN THE HEAD AND NECK adapted from the Summary Staging Guide 1977 published by the SEER Program, and the AJCC Cancer Staging Manual Fifth Edition published by the American Joint Committee on Cancer Staging. Note: Not all sites in the lip, oral cavity, pharynx and salivary glands are listed below. All sites to which a Summary Stage scheme applies are listed at the begining of the scheme. ORAL CAVITY AND ORAL PHARYNX (in ICD-O-3 sequence) The oral cavity extends from the skin-vermilion junction of the lips to the junction of the hard and soft palate above and to the line of circumvallate papillae below. The oral pharynx (oropharynx) is that portion of the continuity of the pharynx extending from the plane of the inferior surface of the soft palate to the plane of the superior surface of the hyoid bone (or floor of the vallecula) and includes the base of tongue, inferior surface of the soft palate and the uvula, the anterior and posterior tonsillar pillars, the glossotonsillar sulci, the pharyngeal tonsils, and the lateral and posterior walls. The oral cavity and oral pharynx are divided into the following specific areas: LIPS (C00._; vermilion surface, mucosal lip, labial mucosa) upper and lower, form the upper and lower anterior wall of the oral cavity. They consist of an exposed surface of modified epider- mis beginning at the junction of the vermilion border with the skin and including only the vermilion surface or that portion of the lip that comes into contact with the opposing lip. -
Increased Kallikrein Content of Saliva from Patients with Cystic Fibrosis of the Pancreas
Pediat. Res. 3: 57 1-578 (1969) Bradykinin kallikrein cystic fibrosis of the pancreas kininase enzymic activity saliva Increased Kallikrein Content of Saliva from Patients with Cystic Fibrosis of the Pancreas A Theory for the Pathogenesis of Abnormal Secretions JACK LIE BERM AN[*^] and GLENND. LITTENBERG Department of Respiratory Diseases, City of Hope Medical Center, Duarte, and the Departments of Medicine, Veterans Administration Hospital, Long Beach, and the University of California School of Medicine, Los Angeles, California, USA Extract An investigation of the bradykinin system in cystic fibrosis of the pancreas was undertaken because of the potential role of bradykinin in the function of glandular tissues and in the mediation of electro- lyte transport. Patients with cystic fibrosis of the pancreas (CFP) and control subjects (CS) were studied for evidence of excessive formation or impaired inactivation of bradykinin in plasma, saliva and urine. Bradykinin, kininase and kallikrein activities were assayed by means of a modified Schultz- Dale apparatus utilizing the uterus of rats in estrus. The bradykinin assay detected as little as 0.01 ,ug bradykinin (4 x ,ug/ml bath solution). The height of uterine contraction was proportional to the logarithmic concentration of bradykinin with maximum contraction occurring with 1-10 ,ug bradykinin. Free bradykininlike activity in urine, saliva or plasma specimens from 11 patients was the same as that from 21 normal controls. In saliva specimens from CFP or CS no bradykininlike activity was detected, whereas in urine there was slight activity in approximately 60% of the samples. Fresh heparinized plasma of both patients and controI subjects developed spontaneous bradykinin activity when added to the muscle bath; this type of activity could be prevented by shaking the plasma with glass beads and incubating at 37' for 30 min. -
Basic Histology (23 Questions): Oral Histology (16 Questions
Board Question Breakdown (Anatomic Sciences section) The Anatomic Sciences portion of part I of the Dental Board exams consists of 100 test items. They are broken up into the following distribution: Gross Anatomy (50 questions): Head - 28 questions broken down in this fashion: - Oral cavity - 6 questions - Extraoral structures - 12 questions - Osteology - 6 questions - TMJ and muscles of mastication - 4 questions Neck - 5 questions Upper Limb - 3 questions Thoracic cavity - 5 questions Abdominopelvic cavity - 2 questions Neuroanatomy (CNS, ANS +) - 7 questions Basic Histology (23 questions): Ultrastructure (cell organelles) - 4 questions Basic tissues - 4 questions Bone, cartilage & joints - 3 questions Lymphatic & circulatory systems - 3 questions Endocrine system - 2 questions Respiratory system - 1 question Gastrointestinal system - 3 questions Genitouirinary systems - (reproductive & urinary) 2 questions Integument - 1 question Oral Histology (16 questions): Tooth & supporting structures - 9 questions Soft oral tissues (including dentin) - 5 questions Temporomandibular joint - 2 questions Developmental Biology (11 questions): Osteogenesis (bone formation) - 2 questions Tooth development, eruption & movement - 4 questions General embryology - 2 questions 2 National Board Part 1: Review questions for histology/oral histology (Answers follow at the end) 1. Normally most of the circulating white blood cells are a. basophilic leukocytes b. monocytes c. lymphocytes d. eosinophilic leukocytes e. neutrophilic leukocytes 2. Blood platelets are products of a. osteoclasts b. basophils c. red blood cells d. plasma cells e. megakaryocytes 3. Bacteria are frequently ingested by a. neutrophilic leukocytes b. basophilic leukocytes c. mast cells d. small lymphocytes e. fibrocytes 4. It is believed that worn out red cells are normally destroyed in the spleen by a. neutrophils b. -
Salivary Glands
GASTROINTESTINAL SYSTEM [Anatomy and functions of salivary gland] 1 INTRODUCTION Digestive system is made up of gastrointestinal tract (GI tract) or alimentary canal and accessory organs, which help in the process of digestion and absorption. GI tract is a tubular structure extending from the mouth up to anus, with a length of about 30 feet. GI tract is formed by two types of organs: • Primary digestive organs. • Accessory digestive organs 2 Primary Digestive Organs: Primary digestive organs are the organs where actual digestion takes place. Primary digestive organs are: Mouth Pharynx Esophagus Stomach 3 Anatomy and functions of mouth: FUNCTIONAL ANATOMY OF MOUTH: Mouth is otherwise known as oral cavity or buccal cavity. It is formed by cheeks, lips and palate. It encloses the teeth, tongue and salivary glands. Mouth opens anteriorly to the exterior through lips and posteriorly through fauces into the pharynx. Digestive juice present in the mouth is saliva, which is secreted by the salivary glands. 4 ANATOMY OF MOUTH 5 FUNCTIONS OF MOUTH: Primary function of mouth is eating and it has few other important functions also. Functions of mouth include: Ingestion of food materials. Chewing the food and mixing it with saliva. Appreciation of taste of the food. Transfer of food (bolus) to the esophagus by swallowing . Role in speech . Social functions such as smiling and other expressions. 6 SALIVARY GLANDS: The saliva is secreted by three pairs of major (larger) salivary glands and some minor (small) salivary glands. Major glands are: 1. Parotid glands 2. Submaxillary or submandibular glands 3. Sublingual glands. 7 Parotid Glands: Parotid glands are the largest of all salivary glands, situated at the side of the face just below and in front of the ear. -
Salivary Glands; the Parotid Submandibular and Sublingual Functions of Saliva
Lecture series Gastrointestinal tract Professor Shraddha Singh, Department of Physiology, KGMU, Lucknow Various secretions from GIT First secretion from GIT that encounter the food is SALIVARY SECRETIONS What is saliva • Saliva is the mixed glandular secretion which constantly bathes the teeth and the oral mucosa • First secretion encounter the food • It is vital for oral health • It is constituted by the secretions of the three paired major salivary glands; The Parotid Submandibular and Sublingual Functions of saliva 1. Defense: a. Antibacterial b. Antifungal c.Immunological 2. Digestive function: a. Digestive enzymes – ptyalin, lipase b. Formation of bolus c. Taste 3. Protective function: a. Protective coating for hard tissues-teeth b. Protective coating for soft tissues 4. Lubricative function: a.Keeps the oral cavity moist b.Facilitates speech c.Helps in mastication and swallowing 5. Buffering function Salivary glands Structure of Salivary Gland Parotid gland • Parotid is large accounts for 50% secretion of saliva • Situated in front of ear behind the ramus of mandible • Gland drain in to oral cavity opposite to second molar tooth • Secretions are basically serous Submandibular and Sub lingual gland • The submandibular gland is about half the size of the parotid gland • It lies above the mylohyoid in the floor of the mouth. It opens into the floor of the mouth underneath the anterior part of the tongue • The sublingual is the smallest of the paired major salivary glands, being about one fifth the size of the submandibular. • It -
Human Eccrine Sweat Contains Tissue Kallikrein and Kininase II
Human Eccrine Sweat Contains Tissue Kallikrein and Kininase II Toshihiko Hibino, Toshiyuki Takemura, and Kenzo Sato Marshall Dermatology Research Laboratories, Department of Dermatology, Universiry of Iowa Co llege of Medicine, Iowa Ciry, Iowa, U.S.A. We attempted to determine the level of sweat kallikrein kallikrein is the glandular type. Purified sweat and salivary (kininogenase) and to purify and characterize it using sweat kallikrein showed similar Mr and responses to inhibitors and collected over a white petrolatum barrier. Thermally induced antibodies. Using immunohistochemistry, kallikrein activity eccrine sweat obtained from 24 healthy subjects showed kal was localized in luminal ductal cells and in the peripheral rirn likrein activity of 24.4 ng kinins generated/1 mg of sweat of secretory coil segments, presumably the outer membrane protein when heated plasma was used as the substrate and of the myoepithelium. We also observed kininase activity in 16.1 ng kinin when purified low molecular weight bovine sweat at Mr 160,000, which was inhibited by ethylenedia kininogen was used as the substrate. Sweat was sequentially mine tetraacetic acid, captopril, and angiotensin converting purified by Sephacryl S-200, diethyaminoethyl Sephacel, enzyme inhibitor peptide, indicating that it is kininase II (or and fast flow liquid chromatography Mono Q chromatogra angiotensin converting enzyme). Sweat also contains abun phy. Sweat kallikrein had aMrof 40,000 and was inhibited by dant non-kallikrein hydrolases for S-2266 and S-2302. The aprotinin but not by soybean trypsin inhibitor. The peptide demonstration of glandular kallikrein, its tissue localization, generated by sweat kallikrein was identified as lys-bradykinin and the presence of kininase II in sweat provide the basis for using reverse phase high-performance liquid chromatogra future studies on the physiologic role of the kallikrein/kinin phy and by its amino acid sequence. -
Salivary Glands Massage
Patient Education Sheet How to Massage Salivary Glands The Foundation thanks Ava J. Wu, DDS for authoring this Patient Education Sheet. Dr. Wu is a Clinical Professor and Co-Director of the Salivary Gland Dysfunction Clinic, School of Dentistry, University of California, San Fr anci sc o. If a sharp and stabbing pain occurs in one of your salivary glands right before or while eating or drinking, the cause might be an obstruction (a stone or mucous plug). In rare cases, associated gland swelling can accompany the discomfort. Here are some tips for massaging or “milking” the gland that might help: Figure 1A: The parotid glands are 2A located bilaterally in the cheek area in front of your ear and have a “tail” area that can extend over the lower jaw. 1A Figure 2A: The submandibular and sublingual glands are located bilaterally under your jaw and 2B tongue with the sublingual gland closer to the chin. Figures 1B and 2B: Place two fingers on the body or 1B tail area of the parotid, Or under the jaw for the submandibular/sublingual glands. 2C Figures 1C and 2C: Sweep fingers forward with gentle pressure as indicated by the black arrows. This will 1C encourage movement of saliva past a possible obstruction or constriction and into the oral cavity. Additional Tips: • Stay well hydrated to encourage the flow of saliva through the gland. • Temporarily avoid foods and beverages that cause the pain and possible swelling. • Apply warm compresses to the area to increase comfort. • Ibuprofen may be taken temporarily to decrease pain and inflammation. -
Oral & Maxillofacial Surgery Removal of Parotid Salivary Gland
Oxford University Hospitals NHS Trust Oral & Maxillofacial Surgery Removal of parotid salivary gland Information for patients This leaflet will help you understand your treatment and should answer many of the questions patients commonly ask before surgery for the removal of a parotid gland. A member of staff will be available if you would like further explanation and to answer any other questions that the leaflet does not cover. What is the parotid gland? The parotid gland lies in front of and below the earlobe. It produces saliva. Saliva drains from the parotid gland through a tube that opens on the inside of the cheek, opposite the upper back teeth. Why do I need my gland removed? The most common reason for removing a parotid gland (or part of the gland) is because a lump has been found inside it. There are also other reasons which your surgeon will discuss with you. What happens before the operation? Pre-assessment clinic – You will be asked to attend an appointment at this clinic. Nursing and/or medical staff will go through some important checks and make certain all relevant investigations have been completed well in advance of the operation date. Admission – You will normally be asked to come to Theatre Direct Admissions or Litchfield Day Surgery Unit on the morning of your operation. The anaesthetist will see you to explain the anaesthetic and answer any questions you may have. They will also be able to advise you about pain relief available after the operation. The surgeon will explain the details of the operation and discuss the possible risks, before asking you to sign a consent form (this may be done at the pre-assessment appointment). -
Saliva Control
• Introduction • Possible problems • What can be done? • Too much saliva • Too little saliva • Thick saliva • Further help Saliva Control Introduction This fact sheet is aimed at those affected by MSA and experiencing difficulties with saliva control. It provides information about the possible problems and advises on what can be done to manage the symptoms. Possible problems Some people may experience discomfort and embarrassment due to reduced saliva control. Saliva plays an important function in the mouth. It helps break down food and protects the mouth from drying out and cracking. However, too much or too little saliva can cause problems, both with eating and drinking and with speech. We all produce about a litre and a half of saliva every day, but in health we swallow frequently. People with MSA have a reduced swallow reflex and difficulty moving saliva from the front of the mouth to the back where it can then be swallowed. Also there may be some increased saliva production by the autonomic nervous system. Alternatively, saliva may be thick and difficult to swallow, and some medication can cause a drying up of saliva and a dry mouth. What can be done? The following advice may help depending on the nature of the saliva problem. The advice is based on medical understanding, commonly held knowledge and strategies that have helped people before. Saliva Control Too much saliva If the problem is too much saliva then a few options are available: Food and Drink: Some foods and drinks can help reduce saliva production. You might try: • Ginger tea - this has a drying effect on the mouth; sucking pieces of dried ginger may help if there is no risk of choking • Dark grape juice • Sage • Pineapple juice or sucking fresh pineapple has a cleansing effect on the mouth. -
Section IX – Digestive System
Section IX – Digestive System The digestive system refers to the alimentary canal or gastrointestinal tract. It consists of organs and glands that break down food products to be used by the body as a source of energy through absorption of nutrients and to eliminate solid waste products. The GI tract begins at the mouth, where food is ingested and ends at the anus, where waste products are eliminated from the body. Medical Terms Combining Forms gingiv/o gums stomat/o, or/o mouth dent/o, odont/o teeth labi/o lip maxill/o jaw sial/o saliva, salivary glands abdomin/o abdomen gastr/o stomach lingu/o, gloss/o tongue myc/o fungus orth/o straight esophag/o esophagus carcin/o cancer rect/o rectum proct/o rectum and anus sigmoid/o sigmoid ile/o ileum col/o colon duoden/o duodenum enter/o intestine hepat/o liver chol/e, chol/o bile, gall cholecyst/o gall bladder pancreat/o pancreas cyst/o bladder an/o anus Suffixes -rrhea discharge, flow -orexia appetite -emesis vomiting -pepsia digestion -phagia swallowing, eating -lith stone Medical Terms Mouth (or/o, stomat/o) or/al, stomat/ic – pertaining to the mouth stomat/o/dynia – pain in the mouth sub/lingu/al – pertaining to under the tongue sub/maxill/ary – pertaining to under the jaw Salivary Glands (sial/o) sial/o/rrhea – excessive flow of saliva sial/o/aden/itis – inflammation of the salivary glands Teeth (odont/o, dent/o) dent/ist – specialist in the study of teeth orth/o/dont/ist – specialist in straight teeth gingiv/itis – inflammation of the gums Stomach (gastr/o) gastr/o/dynia – pain in the stomach