Maternal Variables Included in the NRN Genomics Database
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Duke University: Michael Cotten Maternal Variables Included in the NRN Genomics Database. 14. Obstetric/Maternal items were included in data collection. 1. Whether or not multiple birth 2. Mother’s age 3. Pregnancy History (Gravida/Parity) 4. Marital status at time of baby’s delivery 5. Prenatal Care Y/N (1 visit counts) 6. Insulin dependent diabetes 7. Hypertension/pre-eclampsia/eclampsia 8. Antepartum hemorrhage 9. Timing of rupture of membranes relative to birth 10. Timing relative to birth of onset of labor 11. Antenatal steroids Y/N? 12. Tocolytics Y/N? 13. Antibiotics prior to delivery Y/N? 14. Mode of delivery (C/Section, vaginal) Detailed descriptions from the GDB Manual of Operations in use during the enrollment period for infants whose samples are included in the NICHD NRN Anonymized DNA Bank. 1. Birth Number: The code distinguishes between siblings in the NICU. Twins are coded '1' or '2', for example. It does not necessarily conform to strict birth order from a multiple birth, but is consistent for each baby. 2. Mother's age: Record the age in completed years at the time of delivery. 3. Pregnancy history (include this pregnancy): 3a. Gravida: The number of confirmed pregnancies, including this one. 3b. Parity:The number of products of conception delivered after 20 weeks gestation, resulting in the birth of a child, including this delivery. This includes live births only. Note that each infant of a multiple birth has the same parity. For example, if twins were born and it was the first delivery, then the parity for each twin would be 2. The parity for a singleton birth following these twins would be 3. 4. Marital status: If mother is currently married but separated (including legal separations) use code '1' married. If she is single, divorced or widowed then use code '2' single. If marital status is unknown code '6'. 5. Multiple birth? 5a. Number of fetuses: Include all fetuses, live or stillborn. 6. Mother had at least one pre-natal care visit for this pregnancy. This is our only data to know Prenatal care Y/N. 7. Diabetes - insulin dependent? if diabetes mellitus requiring insulin for control is diagnosed during or prior to present pregnancy. 8. Hypertension/pre-eclampsia/eclampsia? if hypertension, chronic or pregnancy induced, with or without edema and proteinuria, is specifically recorded in the mother's chart, or if a maternal blood pressure above 140 systolic or 90 diastolic recorded prior to or during the present pregnancy. 9. Antepartum hemorrhage? if placenta previa, abruptio or threatened abortion resulting in bleeding, which can be external (vaginal bleeding) or occult (retroplacental clot), other than bloody show, is documented after 20 weeks of pregnancy. 10. Rupture of membranes: 10a. Date: For this study data set, no date will be recorded. Days prior to birth will be inserted in place of the date. For c-sections, if the date is not noted, record the date of birth, or in this data set, Time Zero as the date of rupture of membranes. 10b. Time: This will be time Zero. 11. Was there labor? If YES, onset of labor: Record data for episode of labor which resulted in the birth, in days and time relative to date and time of birth 12. Were steroids given prior to delivery to accelerate pulmonary maturity? As documented in maternal chart, labor and delivery record. 'Y' if corticosteroids, e.g. betamethasone or dexamethasone, given during this pregnancy. 12a. If YES, was a complete course given within 7 days prior to delivery? 'Y' if bethamethasone [2 doses, 12 or 24 hours apart] or dexamethasone [4 doses, 6 hours apart] were given specifically to promote lung maturity and at least 12 hours from the second dose or 24 hours from the first dose has elapsed before delivery. If the time elapsed was less, this would be considered incomplete. Count only doses that occurred within one week prior to delivery. 12b. If YES, total number of courses given during this pregnancy? The number of complete courses the mother has received to accelerate pulmonary maturity (as defined above) during this pregnancy and prior to delivery. 13. Were tocolytics used during the admission resulting in this delivery? ‘Y’ if the mother received pharmacologic agents to control contractions and prevent preterm delivery. These agents include but are not limited to: Magnesium Compounds: Magnesium Sulfate, Magnesium Oxide, Magnesium glutamate Prostaglandin Synthesis Inhibitors: Indomethacin, aspirin, naproxen, fenoprofen Beta-sympathomimetic Agents: Beta adrenergic agonists: terbuline, ritodrine, isoxsuprine, hexoprenaline, fenoterol, orciprenaline, salbutamol Calcium Channel Blockers: Nifedipine, diltiazem, verapamil Other Tocolytics: Oxytocin antagonists, diazoxide, progestagens 14. Were antibiotics used during the admission resulting in this delivery? 'Y' if any antibiotics were used during the admission resulting in this delivery. 15. Final mode of delivery: As documented on labor/delivery sheet. The final mode of delivery, if unknown, recorded as vaginal vertex. .