XPO1 (N) Antibody, Rabbit Polyclonal

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Order: (888)-282-5810 (Phone) (818)-707-0392 (Fax) [email protected] Web: www.Abiocode.com XPO1 (N) Antibody, Rabbit Polyclonal Cat#: R2853-1 Lot#: Refer to vial Quantity: 100 ul Application: WB Predicted I Observed M.W.: 123 kDa Uniprot ID: O14980 Background: Exportin-1 (XPO1) belongs to the exportin family and mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, XPO1 binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Other Names: Exportin-1, Chromosome region maintenance 1 protein homolog, CRM1, EXP1 Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human XPO1. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human, Mouse Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. For research use only. Not for therapeutic or diagnostic purposes. Abiocode, Inc., 29397 Agoura Rd., Ste 106, Agoura Hills, CA 91301 Order: (888)-282-5810 (Phone) (818)-707-0392 (Fax) [email protected] Web: www.Abiocode.com Product Data: A B C D E F G kDa 175 80 58 46 30 Ab: R2853-1 -2 XPO1 (N) (C) Fig 1. Western blot of total cell extracts from A, D) mouse brain, B, E) mouse thymus, C, F) human HeLa, G) human Jurkat; using 2 independent Abs against 2 distinct regions of human XPO1 at RT for 2 h. For research use only. Not for therapeutic or diagnostic purposes. Abiocode, Inc., 29397 Agoura Rd., Ste 106, Agoura Hills, CA 91301.

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1W9c Lichtarge Lab 2006
Pages 1–7 1w9c Evolutionary trace report by report maker June 18, 2010 4.3.1 Alistat 7 4.3.2 CE 7 4.3.3 DSSP 7 4.3.4 HSSP 7 4.3.5 LaTex 7 4.3.6 Muscle 7 4.3.7 Pymol 7 4.4 Note about ET Viewer 7 4.5 Citing this work 7 4.6 About report maker 7 4.7 Attachments 7 1 INTRODUCTION From the original Protein Data Bank entry (PDB id 1w9c): Title: Proteolytic fragment of crm1 spanning six c-terminal heat repeats Compound: Mol id: 1; molecule: crm1 protein; chain: a, b; frag- ment: c-terminal six heat repeats, residues 707-1027; synonym: exportin 1; engineered: yes Organism, scientiﬁc name: Homo Sapiens; 1w9c contains a single unique chain 1w9cA (321 residues long) CONTENTS and its homologue 1w9cB. 1 Introduction 1 2 CHAIN 1W9CA 2.1 O14980 overview 2 Chain 1w9cA 1 2.1 O14980 overview 1 From SwissProt, id O14980, 100% identical to 1w9cA: 2.2 Multiple sequence alignment for 1w9cA 1 Description: Exportin-1 (Chromosome region maintenance 1 protein 2.3 Residue ranking in 1w9cA 2 homolog). 2.4 Top ranking residues in 1w9cA and their position on Organism, scientiﬁc name: Homo sapiens (Human). the structure 2 Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; 2.4.1 Clustering of residues at 25% coverage. 2 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; 2.4.2 Overlap with known functional surfaces at Catarrhini; Hominidae; Homo. 25% coverage. 2 Function: Mediates the nuclear export of cellular proteins (cargoes) 2.4.3 Possible novel functional surfaces at 25% bearing a leucine-rich nuclear export signal (NES) and of RNAs.
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Supporting Information
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