Trans-Anethole: a Key Compound in Bogma Raki
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Comparison of the Effect of Oestrogen Plus Foeniculum Vulgare Seed and Oestrogen Alone on Increase in Endometrial Thickness in I
DOI: 10.7860/JCDR/2018/30164.11020 Original Article Comparison of the Effect of Oestrogen Plus Foeniculum vulgare Section Seed and Oestrogen alone on Obstetrics and Gynaecology Increase in Endometrial Thickness in Infertile Women MAHNAZ YAVANGI1, SOGHRA RABIEE2, SARA NAZARI3, MARZIEH FARIMANI-SANOEE4, IRAJ AMIRI5, MARYAM BAHMANZADEH6, SAEID HEIDARI-SOURESHJANI7 ABSTRACT β-hCG level and increase in oestrogen dose were recorded in Introduction: Foeniculum vulgare seed is used to treat infertility a checklist. The data were analysed by independent t-test and because of phytoestrogenic properties. Chi-square in SPSS version 17.0. Aim: The present study was conducted to compare the effects Results: There were no significant differences in mean age, of F. vulgare plus oestrogen and oestrogen alone on Endometrial BMI, number of years of infertility, number of children, cause Thickness (ET) in infertile women. of infertility, positive β-hCG, failure to achieve adequate endometrial thickness, and increase in oestradiol dose between Materials and Methods: In this study, 92 people with infertility the treatment and control groups (p>0.05). The mean number were enrolled by convenience sampling and randomly divided of days to achieve ET of at least 8 mm was 13.1±3.2 in the into treatment case (45 women) and control (47 women) groups. treatment group and 14.2±3.5 in the control group with no Both groups were administered with oestradiol valerate 2 mg significant difference (p>0.05). tablet three times a day since the third day of the menstrual cycle. Treatment group was also administered with F. vulgare Conclusion: F. -
Suspect and Target Screening of Natural Toxins in the Ter River Catchment Area in NE Spain and Prioritisation by Their Toxicity
toxins Article Suspect and Target Screening of Natural Toxins in the Ter River Catchment Area in NE Spain and Prioritisation by Their Toxicity Massimo Picardo 1 , Oscar Núñez 2,3 and Marinella Farré 1,* 1 Department of Environmental Chemistry, IDAEA-CSIC, 08034 Barcelona, Spain; [email protected] 2 Department of Chemical Engineering and Analytical Chemistry, University of Barcelona, 08034 Barcelona, Spain; [email protected] 3 Serra Húnter Professor, Generalitat de Catalunya, 08034 Barcelona, Spain * Correspondence: [email protected] Received: 5 October 2020; Accepted: 26 November 2020; Published: 28 November 2020 Abstract: This study presents the application of a suspect screening approach to screen a wide range of natural toxins, including mycotoxins, bacterial toxins, and plant toxins, in surface waters. The method is based on a generic solid-phase extraction procedure, using three sorbent phases in two cartridges that are connected in series, hence covering a wide range of polarities, followed by liquid chromatography coupled to high-resolution mass spectrometry. The acquisition was performed in the full-scan and data-dependent modes while working under positive and negative ionisation conditions. This method was applied in order to assess the natural toxins in the Ter River water reservoirs, which are used to produce drinking water for Barcelona city (Spain). The study was carried out during a period of seven months, covering the expected prior, during, and post-peak blooming periods of the natural toxins. Fifty-three (53) compounds were tentatively identified, and nine of these were confirmed and quantified. Phytotoxins were identified as the most frequent group of natural toxins in the water, particularly the alkaloids group. -
Improvement of Resveratrol Permeation Through
pharmaceutics Article Improvement of Resveratrol Permeation through Sublingual Mucosa: Chemical Permeation Enhancers versus Spray Drying Technique to Obtain Fast-Disintegrating Sublingual Mini-Tablets Giulia Di Prima 1,* , Giuseppe Angellotti 1,2 , Amalia Giulia Scarpaci 1, Denise Murgia 1 , Fabio D’agostino 3 , Giuseppina Campisi 2 and Viviana De Caro 1 1 Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy; [email protected] (G.A.); [email protected] (A.G.S.); [email protected] (D.M.); [email protected] (V.D.C.) 2 Dipartimento di Discipline Chirurgiche, Oncologiche e Stomatologiche, Università degli Studi di Palermo, 90127 Palermo, Italy; [email protected] 3 Istituto per lo Studio degli Impatti Antropici e Sostenibilità dell’Ambiente Marino, Consiglio Nazionale delle Ricerche (IAS—CNR), Campobello di Mazara, 91021 Trapani, Italy; [email protected] * Correspondence: [email protected] Abstract: Resveratrol (RSV) is a natural polyphenol with several interesting broad-spectrum pharma- cological properties. However, it is characterized by poor oral bioavailability, extensive first-pass Citation: Di Prima, G.; Angellotti, G.; effect metabolism and low stability. Indeed, RSV could benefit from the advantage of the sublingual Scarpaci, A.G.; Murgia, D.; route of administration. In this view, RSV attitudes to crossing the porcine sublingual mucosa were D’agostino, F.; Campisi, G.; De Caro, evaluated and promoted both by six different chemical permeation enhancers (CPEs) as well as V. Improvement of Resveratrol Permeation through Sublingual by preparing four innovative fast-disintegrating sublingual mini-tablets by spray drying followed Mucosa: Chemical Permeation by direct compression. -
Understanding and Managing the Transition Using Essential Oils Vs
MENOPAUSE: UNDERSTANDING AND MANAGING THE TRANSITION USING ESSENTIAL OILS VS. TRADITIONAL ALLOPATHIC MEDICINE by Melissa A. Clanton A thesis submitted in partial fulfillment of the requirements for the Diploma of Aromatherapy 401 Australasian College of Health Sciences Instructors: Dorene Petersen, Erica Petersen, E. Joy Bowles, Marcangelo Puccio, Janet Bennion, Judika Illes, and Julie Gatti TABLE OF CONTENTS List of Tables and Figures............................................................................ iv Acknowledgments........................................................................................ v Introduction.................................................................................................. 1 Chapter 1 – Female Reproduction 1a – The Female Reproductive System............................................. 4 1b - The Female Hormones.............................................................. 9 1c – The Menstrual Cycle and Pregnancy....................................... 12 Chapter 2 – Physiology of Menopause 2a – What is Menopause? .............................................................. 16 2b - Physiological Changes of Menopause ..................................... 20 2c – Symptoms of Menopause ....................................................... 23 Chapter 3 – Allopathic Approaches To Menopausal Symptoms 3a –Diagnosis and Common Medical Treatments........................... 27 3b – Side Effects and Risks of Hormone Replacement Therapy ...... 32 3c – Retail Cost of Common Hormone Replacement -
Trans-Anethole Ameliorates Obesity Via Induction of Browning in White Adipocytes and Activation of Brown Adipocytes
Biochimie 151 (2018) 1e13 Contents lists available at ScienceDirect Biochimie journal homepage: www.elsevier.com/locate/biochi Research paper Trans-anethole ameliorates obesity via induction of browning in white adipocytes and activation of brown adipocytes Nam Hyeon Kang a, Sulagna Mukherjee a, Taesun Min b, Sun Chul Kang a, * Jong Won Yun a, a Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk, 38453, Republic of Korea b Faculty of Biotechnology, Major of Animal Biotechnology, Jeju National University, Jeju, Republic of Korea article info abstract Article history: To treat obesity, suppression of white adipose tissue (WAT) expansion and activation of brown adipose Received 30 April 2018 tissue (BAT) are considered as potential therapeutic targets. Recent advances have been made in the Accepted 21 May 2018 induction of brown fat-like adipocytes (beige) in WAT, which represents an attractive potential strategy Available online 24 May 2018 for the management and treatment of obesity. Use of natural compounds for browning of white adi- pocytes can be considered as a safe and novel strategy against obesity. Here, we report that trans- Keywords: anethole (TA), a flavoring substance present in the essential oils of various plants, alleviated high fat Adipocytes diet (HFD)-induced obesity in mice models via elevation of the expression of beige-specific genes such as Anti-obesity a Browning Ppargc1 , Prdm16, Ucp1, Cd137, Cited1, Tbx1, and Tmem26. TA also regulated lipid metabolism in white Molecular docking adipocytes via reduction of adipogenesis and lipogenesis as well as elevation of lipolysis and fat Trans-anethole oxidation. Moreover, TA exhibited thermogenic activity by increasing mitochondrial biogenesis in white adipocytes and activating brown adipocytes. -
Hydrogen Sulfide Metabolism and Pulmonary Hypertension
cells Review Hydrogen Sulfide Metabolism and Pulmonary Hypertension Lukas Roubenne 1,2,3, Roger Marthan 1,2,4 , Bruno Le Grand 3 and Christelle Guibert 1,2,* 1 INSERM, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, Avenue du Haut-Lévêque, F-33604 Pessac, France; [email protected] (L.R.); [email protected] (R.M.) 2 Centre de Recherche Cardio-Thoracique de Bordeaux, Univ Bordeaux, U1045, 146 Rue Léo Saignat, F-33000 Bordeaux, France 3 OP2 Drugs, Avenue du Haut Lévêque, F-33604 Pessac, France; [email protected] 4 CHU de Bordeaux, Avenue du Haut Lévêque, F-33604 Pessac, France * Correspondence: [email protected] Abstract: Pulmonary hypertension (PH) is a severe and multifactorial disease characterized by a progressive elevation of pulmonary arterial resistance and pressure due to remodeling, inflammation, oxidative stress, and vasoreactive alterations of pulmonary arteries (PAs). Currently, the etiology of these pathological features is not clearly understood and, therefore, no curative treatment is available. Since the 1990s, hydrogen sulfide (H2S) has been described as the third gasotransmitter with plethoric regulatory functions in cardiovascular tissues, especially in pulmonary circulation. Alteration in H2S biogenesis has been associated with the hallmarks of PH. H2S is also involved in pulmonary vascular cell homeostasis via the regulation of hypoxia response and mitochondrial bioenergetics, which are critical phenomena affected during the development of PH. In addition, H2S modulates + ATP-sensitive K channel (KATP) activity, and is associated with PA relaxation. In vitro or in vivo H2S supplementation exerts antioxidative and anti-inflammatory properties, and reduces PA remodeling. Altogether, current findings suggest that H2S promotes protective effects against PH, and could be a relevant target for a new therapeutic strategy, using attractive H2S-releasing molecules. -
Folk Medicine, Phytochemistry and Pharmacological Application of Piper Marginatum
Revista Brasileira de Farmacognosia 26 (2016) 767–779 ww w.elsevier.com/locate/bjp Review Folk medicine, phytochemistry and pharmacological application of Piper marginatum ∗ Jennifer Brú, Juan David Guzman Departamento de Química y Biología, División de Ciencias Básicas, Universidad del Norte, Barranquilla, Colombia a b s t r a c t a r t i c l e i n f o Article history: Piper marginatum Jacq., Piperaceae, is a widely distributed Neotropical species abundant in the Caribbean, Received 16 February 2016 exhibiting a characteristic winged petiole and a heart-shaped leaf, its two vegetative landmarks for rapid Accepted 31 March 2016 identification. The species has been employed by traditional indigenous cultures for its reputed medicinal properties. The plant is most frequently employed by local healers in Central America, the Antilles and Keywords: South America, for alleviating gastrointestinal ailments, administered as a decoction or infusion for its Piper marginatum tonic, diuretic and carminative effects. These beneficial properties may be attributed to the presence of Piperaceae various phytochemicals within P. marginatum, with most of the studies focusing on the essential oil of Folk medicine the plant. Monoterpenoids, sesquiterpenoids and phenylpropanoids of a varied chemical structure have Phytochemistry Pharmacology been identified in the essential oil, while phenylalkanoids, aristolactams, amides and flavonoids have been Biological applications purified by chromatographic techniques from the extracts. The biological and pharmacological exami- nation of P. marginatum showed that the plant may be a valuable source of mosquitocidal, antifungal, antitumoral and hemostatic agents. Future bioguided research may yield biologically relevant molecules useful in medicine or agriculture. © 2016 Sociedade Brasileira de Farmacognosia. -
Identification of Volatile Active Components in Acori Tatarinowii
Yan et al. BMC Complementary Medicine and Therapies (2020) 20:255 BMC Complementary https://doi.org/10.1186/s12906-020-03020-4 Medicine and Therapies RESEARCH ARTICLE Open Access Identification of volatile active components in Acori Tatarinowii Rhizome essential oil from different regions in China by C6 glioma cells Lu Yan1,2,3, Zhanzhan Liu4,LiXu5, Yiyun Qian1,2,3, Pingping Song1,2,3 and Min Wei1,2,3* Abstract Background: Acori Tatarinowii Rhizome (ATR) is a well-recognized Chinese herbal medicine prescribed to treat neurological disorders. The essential oil (ATEO) is considered as the active fraction of ATR and the content of ATEO is used as the only indicator for ATR content determination. The quality of ATEO varies widely due to region difference; however, little is known about how to study ATEO quality chemically and biologically in response to region difference. Thus, it is of great importance to identify volatile active components in ATEO to conduct quality study. In this study, we analyzed ATEO from different regions in China using chemical component analysis combined with biological activity evaluation. Methods: GC-MS was used to obtain different volatile component profiles of ATEO and significantly changed volatile components were screened out. The neuroprotective activities of ATEO, including anti-oxidation, anti- inflammation and neurotrophic functions, were revealed in C6 glioma cells. The correlation study between the bioactivities and the components was performed. Results: 57 volatile components, including terpenoids, phenylpropanoids, aromatic compounds, and other aliphatic compounds, were identified. 8 volatile components (β-asarone, cis-methyl isoeugenol, γ-asarone, methyleugenol, calarene, longifolene, β-caryophyllene and caryophyllene oxide) from ATEO were significantly changed due to region difference and 2 of them (β-asarone and γ-asarone) showed strong correlation with neuroprotective activities. -
Assessment Report on Pimpinella Anisum L
European Medicines Agency Evaluation of Medicines for Human Use London, 10 August 2006 Doc. Ref: EMEA/HMPC/137421/2006 COMMITTEE ON HERBAL MEDICINAL PRODUCTS (HMPC) DRAFT ASSESSMENT REPORT ON PIMPINELLA ANISUM L. DISCUSSION IN THE HMPC ADOPTION BY HMPC KEYWORDS Herbal medicinal products; HMPC; Assessment report; 7 Westferry Circus, Canary Wharf, London, E14 4HB, UK 1 Tel. (44-20) 74 18 84 00 Fax (44-20) 75 23 70 51 E-mail: [email protected] http://www.emea.eu.int EMEA 2006 Reproduction and/or distribution of this document is authorised for non commercial purposes only provided the EMEA is acknowledged Draft Assessment Report 10 August 2006 PIMPINELLA ANISUM L. (Aniseed and Anise oil) Botanical species Pimpinella anisum L. and variety Botanical family Apiaceae (Umbelliferae) Botanical synonyms Anisum vulgare Gaertn Pimpinella aromatica Bleb Common names Anise, Sweet cumin English Anis vert, Petit anis, French Anis d’Europe French Anis, Aneis, Brotsame, German Süsser Kümmel, German Tauben-anis German Anice verde (Anice vero) Italian Anis verde, Spanish Hierba dulce, Spanish Matafaluga Spanish Part of the plant Fruit (whole cremocarp) Pharmaceutical preparations Herbal drug or herbal drug preparations in solid or liquid dosage forms Rapporteur country Italy Assessors Prof. Vittorio Silano Phone: 0039 06 5994 2774 Fax : 0039 05 5994 2120 e-mail: [email protected] Prof. Gioacchino Calapai Phone: 0039 902212697 Fax: 0039 902213300 e-mail: [email protected] EMEA 2006 2/26 INDEX I. Introduction page 4 II.Clinical Pharmacology “ 4 II.1.1. Phyto-chemical characterization “ 4 II.2 Absorption, metabolism and excretion “ 6 II.2. -
Pesticidal Plants
Pesticidal Plants • Philip C. • Philip Stevenson, R. Steven Belmain and Murray B. Isman Pesticidal Plants From Smallholder Use to Commercialisation Edited by Philip C. Stevenson, Steven R. Belmain and Murray B. Isman Printed Edition of the Special Issue Published in Plants www.mdpi.com/journal/plants Pesticidal Plants Pesticidal Plants From Smallholder Use to Commercialisation Special Issue Editors Philip C. Stevenson Steven R. Belmain Murray B. Isman MDPI • Basel • Beijing • Wuhan • Barcelona • Belgrade Special Issue Editors Philip C. Stevenson Steven R. Belmain Murray B. Isman University of Greenwich University of Greenwich University of British Columbia UK UK Canada Editorial Office MDPI St. Alban-Anlage 66 4052 Basel, Switzerland This is a reprint of articles from the Special Issue published online in the open access journal Plants (ISSN 2223-7747) from 2019 to 2020 (available at: https://www.mdpi.com/journal/plants/special issues/Pesticidal). For citation purposes, cite each article independently as indicated on the article page online and as indicated below: LastName, A.A.; LastName, B.B.; LastName, C.C. Article Title. Journal Name Year, Article Number, Page Range. ISBN 978-3-03928-788-8 (Pbk) ISBN 978-3-03928-789-5 (PDF) Cover image courtesy of Philip C. Stevenson. c 2020 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND. -
Methyl Eugenol: Its Occurrence, Distribution, and Role in Nature, Especially in Relation to Insect Behavior and Pollination
Journal of Insect Science: Vol. 12 | Article 56 Tan and Nishida Methyl eugenol: Its occurrence, distribution, and role in nature, especially in relation to insect behavior and pollination Keng Hong Tan1a* and Ritsuo Nishida2b 1Tan Hak Heng, 20, Jalan Tan Jit Seng, 11200 Penang, Malaysia 2Laboratory of Chemical Ecology, Graduate School of Agriculture, Kyoto University, Kyoto, 606-8502, Japan Abstract This review discusses the occurrence and distribution (within a plant) of methyl eugenol in different plant species (> 450) from 80 families spanning many plant orders, as well as various roles this chemical plays in nature, especially in the interactions between tephritid fruit flies and plants. Keywords: allomone, attractant, Bactrocera, chemical ecology, floral fragrance, insect pollinators, plant–insect interactions, plant semiochemicals, sex pheromone, synomone, tephritid fruit flies Abbreviations: ME, methyl eugenol; RK, raspberry ketone Correspondence: a [email protected], b [email protected], *Corresponding author Editor: Todd Shelly was editor of this paper. Received: 28 April 2011, Accepted: 27 August 2011 Copyright : This is an open access paper. We use the Creative Commons Attribution 3.0 license that permits unrestricted use, provided that the paper is properly attributed. ISSN: 1536-2442 | Vol. 12, Number 56 Cite this paper as: Tan KH, Nishida R. 2012. Methyl eugenol: Its occurrence, distribution, and role in nature, especially in relation to insect behavior and pollination. Journal of Insect Science 12:56 available online: insectscience.org/12.56 Journal of Insect Science | www.insectscience.org 1 Journal of Insect Science: Vol. 12 | Article 56 Tan and Nishida 1. Introduction ME has been successfully used in: a) fruit fly surveys (Tan and Lee 1982) and quarantine Plants produce a huge array of chemicals, detection (see reviews by Metcalf and Metcalf numbering tens of thousands, primarily for 1992; Vargas et al.