DOCSLIB.ORG

Serbian Biochemical Society Seventh Conference

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Serbian Biochemical Society Seventh Conference Serbian Biochemical Society Seventh Conference "Biochemistry of Control in Life and Technology" Faculty of Chemistry Proceedings Belgrade 2017 Serbian Biochemical Society President: Marija Gavrović-Jankulović Vice-president: Suzana Jovanović-Šanta General Secretary: Milan Nikolić Treasurer: Milica Popović Scientific Board Milica Bajčetić David R. Jones Edvard T. Petri Duško Blagojević Suzana Jovanović-Šanta Natalija Polović Polina Blagojević Ivanka Karadžić Tamara Popović Jelena Bogdanović Vesna Kojić Željko Popović Pristov Jelena Kotur- Radivoje Prodanović Nataša Božić Stevuljević Niko Radulović Ivona Baričević-Jones Snežana Marković Ivan Spasojević Jelena Bašić Sanja Mijatović Karmen Stankov Tanja Ćirković Djordje Miljković Aleksandra Stanković Veličković Marina Mitrović Tijana Stanković Milena Ćurčić Jelena Nestorov Ivana Stojanović (ib) Milena Čavić Ivana Nikolić Ivana Stojanović (ibiss) Milena Despotović Milan Nikolić Aleksandra Uskoković Snežana Dragović Miroslav Nikolić Perica J. Vasiljević Marija Gavrović- Zorana Oreščanin- Milan Zarić Jankulović Dušić Aleksandra Zeljković Nevena Grdović Svetlana Paškaš Marko N. Živanović Lidija Israel-Živković Anđelka Petri Milan Žižić Proceedings Editor: Ivan Spasojević Technical secretary: Jelena Nestorov Cover design: Zoran Beloševac Publisher: Faculty of Chemistry, Serbian Biochemical Society Printed by: Colorgrafx, Belgrade Serbian Biochemical Society Seventh Conference with international participation Faculty of Chemistry, University of Belgrade 10.11.2017. Belgrade, Serbia “Biochemistry of Control in Life and Technology” PROGRAMME 10:00-10:10 Welcome message Marija Gavrović-Jankulović (President of the Serbian Biochemical Society) 10:10-10:40 Ario de Marco University of Nova Gorica, Vipava, Slovenia Nanobodies: Towards rational design of immune-reagents (FEBS3+ Lecture) 10:40-11:00 Vladimir P. Beškoski Faculty of Chemistry, University of Belgrade Classical biochemistry / biotechnology and molecular biochemistry / biotechnology of environmental microorganisms in degradation of petroleum products and persistent organic pollutants 11:00-11:20 Jakub Nowak NanoTemper Technologies, Krakow, Poland Microscale thermophoresis and NanoDSF as advanced methods in life science research 11:20-11:50 Coffee break 11:50-12:10 Marija Vidović Institute for Multidisciplinary Research, University of Belgrade Sun as a stressor and/or regulator of plant metabolism: responses to UV radiation and high light 12:10-12:30 Vladimir B. Mihailović Faculty of Science, University of Kragujevac Phytochemical characterization and biological activities of some Gentiana plants from Serbia 12:30-12:50 Marija Genčić Faculty of Science and Mathematics, University of Niš Phytochemical re-examination of well-studied medicinal plants as an useful approach in the discovery of (novel) potentially bioactive natural products – The case of Inula helenium L. 12:50-13:10 Dalibor Stanković The Vinča Institute of Nuclear Sciences, University of Belgrade Nano-structured materials and their application in the detection of biological compounds 13.10-13.40 Poster session 13.40-14.00 Cocktail 14:00-14:20 Ivana Beara Faculty of Sciences, University of Novi Sad Battle against inflammation: polyphenols targeting selective inhibition of cyclooxygenase-2 14:20-14:40 Tamara Saksida Institute for Biological Research “Siniša Stanković”, University of Belgrade The role of macrophage migration inhibitory factor in the development of obesity and altered intestinal permeability 14:40-15:00 Žanka Bojić Trbojević Institute for the Application of Nuclear Energy - INEP, University of Belgrade Galectin-1 ligands in human trophoblasts 15.00-15:20 Discussion and concluding remarks Poster Session Ana Marija Balaž Center of Chemistry, Institute of Chemistry, Technology and Metallurgy, University of Belgrade Semi-rational design of cellobiose dehydrogenase from Phanerochaete chrysosporium for increased oxidative stability and high-throughput screening of library mutants Sanja Berežni Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad Novel lignans from Anthriscus sylvestris: 3'-demethoxy podophyllotoxin and 3'- demethoxypodophyllotoxone Stefan Z. Blagojević Department of Biology and Ecology, Faculty of Science, University of Kragujevac Statistical clustering of IC50 values as bioactive substances cytotoxicity indicators on HCT-116 and SW-480 cell lines of colon cancer Petar Čanović Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac Two newly syhtesized ruthenium(II) polypyridyl complexes induce selective apoptosis of HeLa cancer cells via mitochondrial pathway Nikola Gligorijević Institute for the Application of Nuclear Energy - INEP, University of Belgrade Influence of fibrinogen modifications on its interaction with insulin-like growth factor-binding protein 1 Tamara Janković Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade In vitro comparison of antioxidative potential of differently substituted chalcones Jaroslav Katrlík Institute of Chemistry, Slovak Academy of Sciences Determination of protein glycosylation using lectin-based protein microarrays Jelena Korać Department of Life Sciences, Institute for Multidisciplinary Research, University of Belgrade Ligand and redox interactions of adrenaline with iron at physiological pH Gordana Kovačević Innovation Center of the Faculty of Chemistry, University of Belgrade Protein engineering and development of high-throughput screening methods for glucose-oxidase gene library Branka Lončarević Department of Chemistry, Institute of Chemistry, Technology and Metallurgy, University of Belgrade Application of microbial levan as a new component for production of graft copolymer with polystyrene Ivana Lukić Department of Research and Development, Institute of Virology, Vaccine and Sera „Torlak“, Belgrade The role of heterologous immunity in resistance to ocular chlamydial infection Tatjana Majkić Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad Antioxidant and anti-inflammatory activity of Merlot wine Emilija Marinković Institute of Virology, Vaccines and Sera - Torlak, Belgrade The effect of prophylactic treatment of recombinant banana on TNBS-induced colitis in BALB/C mice Nevena Marković Institute of Chemistry, Technology and Metallurgy, University of Belgrade Synthesis of potential pharmaceutical active ingredients using omega-transaminase Ana Medić School of Medicine, University of Belgrade Biodegradation of 2,6-di-tert-butylphenol by Pseudomonas aeruginosa san ai Ivana Milenković Department of Life Science, Institute for Multidisciplinary Research, University of Belgrade The influence of coated nanoCeO2 on the phenol content in wheat and pea Ivan Mrkić Innovation Centre of Faculty of Chemistry, University of Belgrade Newly designed soluble hemagglutinin-Der p 2 chimera is a potential candidate for allergen specific immunotherapy Ivana Nemeš Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad Chemical composition and antioxidant potential of hydromethanolic extracts of celery (Apium graveolens L.) cultivated at different locations in Vojvodina Danijela Nikodijević Department for Biology and Ecology, Faculty of Science, University of Kragujevac Effects of the bee products on energy status and relative expression of biotransformation and apoptosis genes in healthy and colon cancer cells Teodora Obradović Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade Comparison of prooxidative properties of four different tyrosine kinase inhibitors Miloš Opačić Department of Life Sciences, Institute for Multidisciplinary Research, University of Belgrade Imaging and regional distribution of copper, zinc, manganese and iron in sclerotic hippocampi of patients with mesial temporal lobe epilepsy Snežana Orčić Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad Environmental effect on metallothionein gene expression in honey bee (A. mellifera) Marijana Pavlović Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Belgrade Mechanism of action of novel ruthenium(III) complexes toward cisplatin resistant MDA-MB231 breast cells Vladana Petković Vinča Institute of Nuclear Sciences, University of Belgrade Direct effects of γ-rays in MCF-7 breast cancer cells Diandra Pintać Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad Is wine price a guarantee for its healthful properties? Jovana J. Plavša Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad Identification of potential inhibitors of AKR1C3 and preparation for structural analyses Ivana Prodić Faculty of Chemistry – Innovation Centre Ltd., University of Belgrade Whole grain of peanut digestomics according to harmonized static digestion protocol suitable for solid food and characterization of short digestion resistant fragments. Marija Stanojević Institute for Pathological Physiology, Faculty of Medicine, University of Belgrade Minor depolarization mediates magnesium suppression of nonsynaptic epileptiform activity Nikola Tatalović Department of Physiology, Institute for Biological Research “Siniša Stanković”, University of Belgrade The effects of ibogaine on uterine redox homeostasis and contractility Tamara Uzelac Faculty of Chemistry, University of Belgrade Serum
Load more

Recommended publications
  • Figure S1. Heat Map of R (Pearson's Correlation Coefficient)
    Figure S1. Heat map of r (Pearson’s correlation coefficient) value among different samples including replicates. The color represented the r value. Figure S2. Distributions of accumulation profiles of lipids, nucleotides, and vitamins detected by widely-targeted UPLC-MC during four fruit developmental stages. The colors indicate the proportional content of each identified metabolites as determined by the average peak response area with R scale normalization. PS1, 2, 3, and 4 represents fruit samples collected at 27, 84, 125, 165 Days After Anthesis (DAA), respectively. Three independent replicates were performed for each stages. Figure S3. Differential metabolites of PS2 vs PS1 group in flavonoid biosynthesis pathway. Figure S4. Differential metabolites of PS2 vs PS1 group in phenylpropanoid biosynthesis pathway. Figure S5. Differential metabolites of PS3 vs PS2 group in flavonoid biosynthesis pathway. Figure S6. Differential metabolites of PS3 vs PS2 group in phenylpropanoid biosynthesis pathway. Figure S7. Differential metabolites of PS4 vs PS3 group in biosynthesis of phenylpropanoids pathway. Figure S8. Differential metabolites of PS2 vs PS1 group in flavonoid biosynthesis pathway and phenylpropanoid biosynthesis pathway combined with RNA-seq results. Table S1. A total of 462 detected metabolites in this study and their peak response areas along the developmental stages of apple fruit. mix0 mix0 mix0 Index Compounds Class PS1a PS1b PS1c PS2a PS2b PS2c PS3a PS3b PS3c PS4a PS4b PS4c ID 1 2 3 Alcohols and 5.25E 7.57E 5.27E 4.24E 5.20E
    [Show full text]
  • Molecular Docking Study on Several Benzoic Acid Derivatives Against SARS-Cov-2
    molecules Article Molecular Docking Study on Several Benzoic Acid Derivatives against SARS-CoV-2 Amalia Stefaniu *, Lucia Pirvu * , Bujor Albu and Lucia Pintilie National Institute for Chemical-Pharmaceutical Research and Development, 112 Vitan Av., 031299 Bucharest, Romania; [email protected] (B.A.); [email protected] (L.P.) * Correspondence: [email protected] (A.S.); [email protected] (L.P.) Academic Editors: Giovanni Ribaudo and Laura Orian Received: 15 November 2020; Accepted: 1 December 2020; Published: 10 December 2020 Abstract: Several derivatives of benzoic acid and semisynthetic alkyl gallates were investigated by an in silico approach to evaluate their potential antiviral activity against SARS-CoV-2 main protease. Molecular docking studies were used to predict their binding affinity and interactions with amino acids residues from the active binding site of SARS-CoV-2 main protease, compared to boceprevir. Deep structural insights and quantum chemical reactivity analysis according to Koopmans’ theorem, as a result of density functional theory (DFT) computations, are reported. Additionally, drug-likeness assessment in terms of Lipinski’s and Weber’s rules for pharmaceutical candidates, is provided. The outcomes of docking and key molecular descriptors and properties were forward analyzed by the statistical approach of principal component analysis (PCA) to identify the degree of their correlation. The obtained results suggest two promising candidates for future drug development to fight against the coronavirus infection. Keywords: SARS-CoV-2; benzoic acid derivatives; gallic acid; molecular docking; reactivity parameters 1. Introduction Severe acute respiratory syndrome coronavirus 2 is an international health matter. Previously unheard research efforts to discover specific treatments are in progress worldwide.
    [Show full text]
  • Phenolic Acid Profiles of Endemic Species Verbascum Anisophyllum
    ISSN 1314-6246 Nikolova et al. 2016 J. BioSci. Biotech. 2017, 6(3): 163-167 RESEARCH ARTICLE Milena Nikolova Phenolic acid profiles of endemic species Strahil Berkov Marina Dimitrova Verbascum anisophyllum and Verbascum Boryana Sidjimova davidoffii Stoyan Stoyanov Marina Stanilova Authors’ addresses: ABSTRACT 1 Institute of Biodiversity and The profiles of methanol extractable and methanol insoluble bound phenolic acids of Ecosystem Research, Bulgarian Academy of Sciences 23, Acad. G. two species: Verbascum anisophyllum Murb (Balkan endemic) and Verbascum Bonchev Str., 1113 Sofia, Bulgaria. davidoffii Murb. (Bulgarian endemic) were determined. Free radical scavenging activity and total phenolic content of studied extracts and fractions were evaluated by Correspondence: DPPH antioxidant method and Folin–Ciocalteu reagent, respectively. Phenolic acid Milena Nikolova Institute of Biodiversity and Ecosystem profiles were analyzed by GC/MS. Sixteen phenolic acids and their derivatives were Research, Bulgarian Academy of detected. Ferulic acid was the major individual phenolic acid presented in all extracts Sciences 23, Acad. G. Bonchev Str., and fractions. Hydroxycinnamic, vanillic and p-hydroxybenzoic acids were also 1113 Sofia, Bulgaria. Tel.: +359 2 9793758 abundant in the studied phenolic acid profiles. The presence of gentisic, syringic, Fax: +359 2 8705498 isoferulic, dihydroferulic, eudesmic, 3,5-di-tert-butyl-4-hydroxybenzoic acids were e-mail: [email protected] reported for the first time to Verbascum species. The greatest variety of phenolic acids was found in the fractions containing methanol insoluble bound hydrolysable phenolic Article info: Received: 8 December 2017 acids. The highest free radical scavenging activity and total phenolic content were Accepted: 31 December 2017 established for methanol extractable alkaline hydrolysable fractions.
    [Show full text]
  • Natural Products As Chemopreventive Agents by Potential Inhibition of the Kinase Domain in Erbb Receptors
    Supplementary Materials: Natural Products as Chemopreventive Agents by Potential Inhibition of the Kinase Domain in ErBb Receptors Maria Olivero-Acosta, Wilson Maldonado-Rojas and Jesus Olivero-Verbel Table S1. Protein characterization of human HER Receptor structures downloaded from PDB database. Recept PDB resid Resolut Name Chain Ligand Method or Type Code ues ion Epidermal 1,2,3,4-tetrahydrogen X-ray HER 1 2ITW growth factor A 327 2.88 staurosporine diffraction receptor 2-{2-[4-({5-chloro-6-[3-(trifl Receptor uoromethyl)phenoxy]pyri tyrosine-prot X-ray HER 2 3PP0 A, B 338 din-3-yl}amino)-5h-pyrrolo 2.25 ein kinase diffraction [3,2-d]pyrimidin-5-yl]etho erbb-2 xy}ethanol Receptor tyrosine-prot Phosphoaminophosphonic X-ray HER 3 3LMG A, B 344 2.8 ein kinase acid-adenylate ester diffraction erbb-3 Receptor N-{3-chloro-4-[(3-fluoroben tyrosine-prot zyl)oxy]phenyl}-6-ethylthi X-ray HER 4 2R4B A, B 321 2.4 ein kinase eno[3,2-d]pyrimidin-4-ami diffraction erbb-4 ne Table S2. Results of Multiple Alignment of Sequence Identity (%ID) Performed by SYBYL X-2.0 for Four HER Receptors. Human Her PDB CODE 2ITW 2R4B 3LMG 3PP0 2ITW (HER1) 100.0 80.3 65.9 82.7 2R4B (HER4) 80.3 100 71.7 80.9 3LMG (HER3) 65.9 71.7 100 67.4 3PP0 (HER2) 82.7 80.9 67.4 100 Table S3. Multiple alignment of spatial coordinates for HER receptor pairs (by RMSD) using SYBYL X-2.0. Human Her PDB CODE 2ITW 2R4B 3LMG 3PP0 2ITW (HER1) 0 4.378 4.162 5.682 2R4B (HER4) 4.378 0 2.958 3.31 3LMG (HER3) 4.162 2.958 0 3.656 3PP0 (HER2) 5.682 3.31 3.656 0 Figure S1.
    [Show full text]
  • Supplementary Materials
    Figure S1: Metabolite distribution by PCA analysis in sweet corn cultivars. A clear distinction can be observed among the three cultivars. The three dots in each group are representative of the pooled samples performed for this study. In total, 30 biological replications were performed per cultivar, every ten of which were pooled to give one pooled sample. Mix is the mixture of JZY, JBT and CPL. Figure S2. HCA analysis of sweetcorn kernels from the three accessions. Figure S3. OPLS-DA analysis of sweetcorn kernels from the three accessions in pairs. (A), OPLS-DA model; (B), OPLS-DA scores plot, the three dots in each group are representative of the pooled samples performed for this study. In total, 30 biological replications were performed per cultivar, every ten of which were pooled to give one pooled sample; (C), OPLS-DA S-plot, red dots indicate the distinctive compounds (VIP≥1); (D), OPLS-DA permutation test (n=200), the horizontal lines indicate R2Y and Q2 in the original model, red dot and blue dot represent R2Y’ and Q2’ of the model after Y replacement, respectively. All R2Y’ dots are below the original R2Y line, and all Q2’ dots are below the original Q2 line, indicating the OPLS-DA model is validate and suitable. Figure S4. Mass spectrum of potential metabolite markers related to grain quality traits in sweet corn. (A), skimmin; (B), N’,N’’-diferuloylspermidine; (C), 3-hydroxyanthranilic acid. Table S1. The gradient program for HPLC analysis in various sweet corn kernels. Time Flow rate % A % B (min) (mL/min) 0.0 0.4 95 5 Gradient program 11.0 0.4 5 95 12.0 0.4 5 95 12.1 0.4 95 5 15.0 0.4 95 5 Table S2.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2009/0269772 A1 Califano Et Al
    US 20090269772A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2009/0269772 A1 Califano et al. (43) Pub. Date: Oct. 29, 2009 (54) SYSTEMS AND METHODS FOR Publication Classification IDENTIFYING COMBINATIONS OF (51) Int. Cl. COMPOUNDS OF THERAPEUTIC INTEREST CI2O I/68 (2006.01) CI2O 1/02 (2006.01) (76) Inventors: Andrea Califano, New York, NY G06N 5/02 (2006.01) (US); Riccardo Dalla-Favera, New (52) U.S. Cl. ........... 435/6: 435/29: 706/54; 707/E17.014 York, NY (US); Owen A. (57) ABSTRACT O'Connor, New York, NY (US) Systems, methods, and apparatus for searching for a combi nation of compounds of therapeutic interest are provided. Correspondence Address: Cell-based assays are performed, each cell-based assay JONES DAY exposing a different sample of cells to a different compound 222 EAST 41ST ST in a plurality of compounds. From the cell-based assays, a NEW YORK, NY 10017 (US) Subset of the tested compounds is selected. For each respec tive compound in the Subset, a molecular abundance profile from cells exposed to the respective compound is measured. (21) Appl. No.: 12/432,579 Targets of transcription factors and post-translational modu lators of transcription factor activity are inferred from the (22) Filed: Apr. 29, 2009 molecular abundance profile data using information theoretic measures. This data is used to construct an interaction net Related U.S. Application Data work. Variances in edges in the interaction network are used to determine the drug activity profile of compounds in the (60) Provisional application No. 61/048.875, filed on Apr.
    [Show full text]
  • Bioactive Compounds in Waste By-Products from Olive Oil Production: Applications and Structural Characterization by Mass Spectrometry Techniques
    foods Review Bioactive Compounds in Waste By-Products from Olive Oil Production: Applications and Structural Characterization by Mass Spectrometry Techniques Ramona Abbattista 1, Giovanni Ventura 1 , Cosima Damiana Calvano 2,3,* , Tommaso R. I. Cataldi 1,2 and Ilario Losito 1,2,* 1 Chemistry Department, University of Bari Aldo Moro, via Orabona 4, 70126 Bari, Italy; [email protected] (R.A.); [email protected] (G.V.); [email protected] (T.R.I.C.) 2 Interdepartmental Centre SMART, University of Bari Aldo Moro, via Orabona 4, 70126 Bari, Italy 3 Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via Orabona 4, 70126 Bari, Italy * Correspondence: [email protected] (C.D.C.); [email protected] (I.L.) Abstract: In recent years, a remarkable increase in olive oil consumption has occurred worldwide, favoured by its organoleptic properties and the growing awareness of its health benefits. Currently, olive oil production represents an important economic income for Mediterranean countries, where roughly 98% of the world production is located. Both the cultivation of olive trees and the production of industrial and table olive oil generate huge amounts of solid wastes and dark liquid effluents, including olive leaves and pomace and olive oil mill wastewaters. Besides representing an economic problem for producers, these by-products also pose serious environmental concerns, thus their partial reuse, like that of all agronomical production residues, represents a goal to pursue. This Citation: Abbattista, R.; Ventura, G.; aspect is particularly important since the cited by-products are rich in bioactive compounds, which, Calvano, C.D.; Cataldi, T.R.I.; Losito, once extracted, may represent ingredients with remarkable added value for food, cosmetic and I.
    [Show full text]
  • A Review on Phytochemical Constituents of Abutilon Indicum (Link) Sweet – an Important Medicinal Plant in Ayurveda
    Plantae Scientia – An International Research Journal in Botany Publishing Bimonthly Open Access Journal Plantae Scientia : Volume 03, Issue 03, May 2020 REVIEW ARTICLE A Review on Phytochemical constituents of Abutilon indicum (Link) Sweet – An Important Medicinal Plant in Ayurveda 1Suryawanshi Venkat S. and 2Umate Suvarna R. 1Department of Chemistry, P.G. and Research Centre, Shri Chhatrapati Shivaji College, Omerga. Dist. Osmanabad 2Department of Botany, Adarsh College, Omerga, Dist. Osmanabad (MS), India Corresponding Author: [email protected] Manuscript Details ABSTRACT Manuscript Submitted : 12/05/2020 Manuscript Revised : 13/05/2020 Abutilon indicum (Link) Sweet is a medicinal shrub belonging to the Manuscript Accepted : 14/05/2020 family Malvaceae; It has been extensively used as a traditional Manuscript Published : 20/05/2020 medicine to cure different diseases. It is considered invasive on certain tropical islands. The plant is very much used in Ayurveda & Available On Siddha medicines in Tamilnadu. In fact, the bark, root, leaves, flowers and seeds are all used for medicinal purposes. The phytochemical https://plantaescientia.com/ojs analysis showed the Presence of alkaloid, saponins, amino acid, flavonoids, glycosides and steroids. Some important essential oil Cite This Article As constituents like α-pinene, mucilage, tannins, caryophyllene, asparagines, caryophylleneoxide, endesmol, farnesol, borenol, Surywanshi V. S. & S. R. Umate, (2020). A review on Phytochemical constituents of geraniol, geranyl acetate, elemene and α-cineole have been reported Abutilon indicum (Link) Sweet – An from plant. Phytoconstituents like β‐Sitosterol, caffeic acid, fumaric important medicinal plant in Ayurveda., Pla. acid, vanillin, p‐coumaricacid, p‐hydroxybenzoic acid, sesquiterpene Sci. 2020; Vol. 03 Iss. 03:15-19.
    [Show full text]
  • Biobiopha Cat 1.Xlsx
    BBP No. Chemical Name CAS No. Structure M. F. M. W. Descr. Type O H H N BBP00001 Gelsemine 509-15-9 C20 H22 N2O2 322.4 Powder Alkaloids N O H N H BBP00002 Koumine 1358-76-5 C20 H22 N2O 306.4 Powder Alkaloids H N O H O BBP00003 Humantenmine 82354-38-9 N C19 H22 N2O3 326.4 Cryst. Alkaloids NO O N N H H H BBP00004 Ajmalicine 483-04-5 C21 H24 N2O3 352.4 Cryst. Alkaloids H O O O O OH N BBP00005 Vasicinolone 84847-50-7 C11 H10 N2O3 218.2 Powder Alkaloids N OH O BBP00011 Humantenine 82375-29-9 N C21 H26 N2O3 354.5 Powder Alkaloids NO O OO OH BBP00012 (Z)-Akuammidine 113973-31-2 N C21 H24 N2O3 352.4 Cryst. Alkaloids N H H H N BBP00018 Vasicine 6159-55-3 N C11 H12 N2O 188.2 Powder Alkaloids OH N BBP00023 Vindoline 2182-14-1 H C25 H32 N2O6 456.5 Oil Alkaloids O N OAc H OH COOMe N N H HH BBP00054 Tetrahydroalstonine 6474-90-4 C21 H24 N2O3 352.4 Solid Alkaloids H O O O O OH BBP00058 1H-Indole-3-carboxylic acid 771-50-6 C9H7NO 2 161.2 Powder Alkaloids N H N Pale yellow BBP00061 Canthin-6-one 479-43-6 N C H N O 220.2 Alkaloids 14 8 2 needles O O N BBP00064 Gelsevirine 38990-03-3 C21 H24 N2O3 352.4 Solid Alkaloids NO O + N N BBP00065 Sempervirine 6882-99-1 C19 H16 N2 272.4 Yellow powder Alkaloids OH N BBP00067 Vasicinol 5081-51-6 N C11 H12 N2O2 204.2 Powder Alkaloids OH O H N H BBP60007 Matrine 519-02-8 C15 H24 N2O 248.4 Powder Alkaloids H H N O H N H BBP60008 Oxymatrine 16837-52-8 C15 H24 N2O2 264.4 Powder Alkaloids H H N O OH + N O BBP60009 Jatrorrhizine 3621-38-3 O C20 H20 NO 4 338.4 Yellow powder Alkaloids O O + N O Yellow powder BBP60010 Palmatine
    [Show full text]
  • Isolation and Identification of Phenolic Compounds from Boswellia Ovalifoliolata Bal
    Available online on www.ijddt.com International Journal of Drug Delivery Technology 2014; 4(1); 14-21 ISSN: 0975 4415 Research Article Isolation and Identification of Phenolic Compounds from Boswellia ovalifoliolata Bal. & Henry and Their Free Radical Scavenger Activity Savithramma N, *Linga Rao M, Venkateswarlu P Department of Botany, S.V. University, Tirupati-517502, A.P, India Available online: 1st January 2014 ABSTRACT Boswellia ovalifoliolata Bal. and Henry (Burseraceae) is a potential medicinal tree used traditionally in the treatment of ulcers, inflammation, arthritis, obesity and diabetes. The present study aimed to isolate phenolic compounds from stem bark and gum and test for the ability of the extracted phenols of Boswellia ovalifoliolata. Total 78 phenolic compounds were obtained when the plant materials were processed through 70% acetone and poly vinyl poly pyrrolidone; and characterized by U.V. Visible spectrometry, High performance liquid chromatography/ electrospray ionization mass spectrometry. Among the isolated phenols, 28 phenolic compounds have been identified based on their retention time and m/z values. These phenols have showed good antioxidant activity the highest hydrogen peroxide (H2O2) radical scavenging effect of the isolated phenolic compounds has been recorded at 81.8% when compared to the DPPH; and superoxide ion activities with reference to ascorbic acid. This study illustrate the rich array of phenolic compounds and their free radical scavenging activity of stem bark and gum of Boswellia ovalifoliolata could be utility as health beneficial bioactive compounds. Key words: Boswellia ovalifoliolata, stembark, gum, phenolic compounds, Electro Spray Ionization mass spectrometry, hydrozen peroxide INTRODUCTION orally in small quantities (10 ml) two times a day to cure Boswellia ovalifoliolata Bal.
    [Show full text]
  • Identificación De Nuevos Compuestos Lideres Con Actividad Antileishmaniásica a Través De Estudios “In Silico”
    UNIVERSIDAD CENTRAL “MARTA ABREU” DE LAS VILLAS FACULTAD DE QUÍMICA-FARMACIA DEPARTAMENTO DE FARMACIA Identificación de nuevos compuestos lideres con actividad Antileishmaniásica a través de estudios “in silico” Tesis para optar por el Título de Licenciada en Ciencias Farmacéuticas Autora: Judith Louvina Sayers Tutores: Lic. Naiví Flores Balmaseda Dr. Yovani Marrero Ponce Curso 2009-2010 After climbing a great hill, one only finds that there are many more hills to climb. Nelson Mandela Dedicatoria A mi hijo con mucha dedicación y amor. A mis padres por traerme al mundo y luego enseñarme a vivir. Agradecimientos Es un placer para mí expresar mis sinceros agradecimientos a todas aquellas personas de una forma u otra me ha ayudado a culminar exitosamente mis estudios y este trabajo. Quisiera agradecer especialmente por todo el apoyo y el amor que me han brindado durante todo el transcurso de mi carrera. A mis tutores Naiví y Yavani por su apoyo, ánimo y dirección durante el desarrollo de este trabajo. Al Grupo de Diseño de Fármacos por su atención y toda la ayuda que me ha brindado para el desarrollo de esta tesis. A mis compañeros de aula especialmente mis amigas que viven con migo por estar conmigo en los momentos buenos y malos durante estos cinco años de mi vida estudiantil. A mi esposo y su familia que cuidan el hijo mio permitiendome terminar mis estudios. A todos muchas gracias. RESUMEN La leishmaniasis es una enfermedad zoonótica causada por diferentes especies de protozoos del género Leishmania. Sus manifestaciones clínicas van desde úlceras cutáneas, que cicatrizan espontáneamente, hasta formas fatales en las cuales se presenta inflamación severa del hígado y el bazo, pudiendo interesarse otros órganos como los riñones y la médula ósea.
    [Show full text]
  • Stern-Volmer Plot (Dopac-BSA)
    A Comparative Study of the Binding Constants of Several Polyphenols with BSA and LDL-VLDL through Fluorescence Quenching: A Potential Tool in the Fight against Atherosclerosis A thesis presented to the faculty of the Chemistry Department of the University of Scranton as a prerequisite for the degree of Master of Arts in Biochemistry By: Dana Poloni Date: June 9, 2015 Table of Contents Table of Contents………………………………………………………………………...III List of Figures………………………………………………………………………….VIII List of Tables………………………………………………………………………..........X Acknowledgements………………………………………………………………………XI Abstract…………………………………………………………………………………XII 1.0 Introduction……………………………………………………………………………1 1.1 Phenolic acids: Benzoic Acids and their Derivatives…………………………5 1.2 Phenolic acids: Phenylacetic Acids and their Derivatives…………………...12 1.3 Phenolic acids: Cinnamic Acids and their Derivatives………………………15 1.4 Stilbenoids: Stilbenes………………………………………………………...25 1.5 Flavonoids: Flavones………………………………………………………...28 1.6 Flavonoids: Isoflavones……………………………………………………...30 1.7 Flavonoids: Flavonols………………………………………………………..32 1.8 Flavonoids: Anthocyanidins…………………………………………………34 1.9 Thesis Overview……………………………………………………………..35 2.0 Materials and Methods……………………………………………………………….41 2.1 Reagents……………………………………………………………………...41 2.2 Polyphenols…………………………………………………………………..41 2.3 Materials……………………………………………………………………..42 2.4 PBS Solution Preparation……………………………………………………43 2.5 Polyphenol Standards Preparation…………………………………………...44 2.6 BSA Standard Preparation…………………………………………………...44 2.7 Isolation of Porcine
    [Show full text]