#M040570

Panx1 Antibody Order 021-34695924

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Description:

The pannexin family encodes a second class of putative and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.

Uniprot: Q96RD7

Alternative Names: innexin; MRS1; Pannexin 1; Panx1; PX1;

Specificity: Antibody detects endogenous levels of total PANX1.

Reactivity: Human, Mouse, Rat

Source: Mouse

Mol.Wt.: 48 kDa

Storage Condition: Store at -20 °C. Stable for 12 months from date of receipt.

1 For in vitro research use only and not intended for use in humans or animals.

Application: WB 1:1000-1:2000;IHC/IF 1:100-1:1000

Western blot analysis of PANX1 expression in SH-SY5Y whole cell lysates,

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2 For in vitro research use only and not intended for use in humans or animals.