Lectures and Seminars, Hilary Term 2014
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A Brief History of Christ Church MEDIEVAL PERIOD
A Brief History of Christ Church MEDIEVAL PERIOD Christ Church was founded in 1546, and there had been a college here since 1525, but prior to the Dissolution of the monasteries, the site was occupied by a priory dedicated to the memory of St Frideswide, the patron saint of both university and city. St Frideswide, a noble Saxon lady, founded a nunnery for herself as head and for twelve more noble virgin ladies sometime towards the end of the seventh century. She was, however, pursued by Algar, prince of Leicester, for her hand in marriage. She refused his frequent approaches which became more and more desperate. Frideswide and her ladies, forewarned miraculously of yet another attempt by Algar, fled up river to hide. She stayed away some years, settling at Binsey, where she performed healing miracles. On returning to Oxford, Frideswide found that Algar was as persistent as ever, laying siege to the town in order to capture his bride. Frideswide called down blindness on Algar who eventually repented of his ways, and left Frideswide to her devotions. Frideswide died in about 737, and was canonised in 1480. Long before this, though, pilgrims came to her shrine in the priory church which was now populated by Augustinian canons. Nothing remains of Frideswide’s nunnery, and little - just a few stones - of the Saxon church but the cathedral and the buildings around the cloister are the oldest on the site. Her story is pictured in cartoon form by Burne-Jones in one of the windows in the cathedral. One of the gifts made to the priory was the meadow between Christ Church and the Thames and Cherwell rivers; Lady Montacute gave the land to maintain her chantry which lay in the Lady Chapel close to St Frideswide’s shrine. -
President's Message
Winter Issue 2013–2014 SOT News President’s Message I’m starting this President’s message with a quiz!!! It’s just one question, but it’s important that everyone knows the answer. The question is: What do prenatal programming and toxicity, perfluorinalkyl acids ,and human relevance of hemangiosarcomas in rodents have in common? [the answer appears at the end of this message]. While you ponder the answer to that question, I want to reflect on events of this fall and focus on several activities of the Society during recent times of uncertainty. The shutdown of the US government had some effect on nearly all of us. Important meetings, study sections, and day-to- day professional discussion and dialog were all furloughed during this time. However, the most significant impact was on our members who are government employees, and we can only hope that these matters are completely behind us. Unfortunately, there were significant deadlines for SOT matters scheduled during this time, particularly for abstract submissions and award President nominations. Lois D. Lehman- McKeeman I want to specifically acknowledge the work of the Scientific Program and Awards Committees for showing remarkable flexibility in modifying deadlines to accommodate member needs. As a quick review, the Awards committee moved deadlines for nominations to the last possible minute—giving them only about 1 week to review all nominations prior to meeting to select award winners. The prestigious Society awards are central to celebrating member accomplishments, and the work of this committee, against their own time limitations, underscores their commitment to this important activity. -
Tick Saliva and Its Role in Pathogen Transmission
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by NERC Open Research Archive lyme borreliosis Wien Klin Wochenschr https://doi.org/10.1007/s00508-019-1500-y Tick saliva and its role in pathogen transmission Patricia A. Nuttall Received: 22 February 2019 / Accepted: 9 April 2019 © The Author(s) 2019 Summary Tick saliva is a complex mixture of peptidic cle of egg, larva, nymph, and adult (female or male). and non-peptidic molecules that aid engorgement. Each postembryonic stage generally requires a blood The composition of tick saliva changes as feeding meal before moulting to the next stage [2]. During progresses and the tick counters the dynamic host blood-feeding, ticks acquire infections they may sub- response. Ixodid ticks such as Ixodes ricinus,the sequently transmit when feeding again. When this most important tick species in Europe, transmit nu- occurs, ticks act as vectors of potential pathogens of merous pathogens that cause debilitating diseases, humans and other animals [3]. In fact, ticks are be- e.g. Lyme borreliosis and tick-borne encephalitis. lieved to transmit the greatest variety of infectious Tick-borne pathogens are transmitted in tick saliva agents of any blood-feeding vector. Notable diseases during blood feeding; however, saliva is not simply of humans caused by tick-borne pathogens include a medium enabling pathogen transfer. Instead, tick- Lyme borreliosis, tick-borne encephalitis (TBE), tu- borne pathogens exploit saliva-induced modulation laremia, babesiosis, rickettsiosis, and human granu- of host responses to promote their transmission and locytic anaplasmosis; however, tick-borne infectious infection, so-called saliva-assisted transmission (SAT). -
Society for Developmental Biology 64Th Annual Meeting
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Developmental Biology 283 (2005) 537 – 574 www.elsevier.com/locate/ydbio Society for Developmental Biology 64th Annual Meeting Hyatt Regency, San Francisco, CA July 27–August 1, 2005 Organizing Committee: Judith Kimble (Chair, SDB President), Kathy Barton, Minx Fuller, Nipam Patel, Didier Stainier, Xin Sun, Bill Wood Local Organizers: Didier Stainier, Ida Chow Numbers in italics are program abstract numbers and names in bold are speakers. Poster assignments are listed at the end of the meeting program. Program Wednesday, July 27 9 am–5 pm Satellite Symposia (not organized by SDB) Segmentation Seacliff AB Co-organizers: Kenro Kusumi and Olivier Pourquie´ Molecular Biology of Plant Development Seacliff CD Organizer: Kathy Barton 12–7 pm Meeting Registration Grand Foyer Poster Session I and Exhibits Set-up Pacific Concourse See poster assignments at the end of the program 7–9 pm President’s Symposium Grand Ballroom Fundamental Problems of Developmental Biology Chair: Judith Kimble, University of Wisconsin-Madison and HHMI, Madison, WI 7:00 The soma-germline dichotomy. G. Seydoux. Johns Hopkins University, Baltimore, MD 1 7:40 MicroRNAs and their regulatory roles in plants and animals. D.P. Bartel. MIT and Whitehead Institute for Biomedical Research, Cambridge, MA 8:20 The genetics and genomics of evolving new traits in vertebrates. D. Kingsley. Stanford University and HHMI, Stanford, CA 9–11 pm Opening Reception in Honor of Eric Olson, Pacific Concourse Developmental Biology Editor-in-Chief, for invaluable service to the community Poster Session I and Exhibits Pacific Concourse See poster assignments at the end of the program YDBIO-02007; No. -
Gurdon Institute 20122011 PROSPECTUS / ANNUAL REPORT 20112010
The Wellcome Trust/Cancer Research UK Gurdon Institute 20122011 PROSPECTUS / ANNUAL REPORT 20112010 Gurdon I N S T I T U T E PROSPECTUS 2012 ANNUAL REPORT 2011 http://www.gurdon.cam.ac.uk CONTENTS THE INSTITUTE IN 2011 INTRODUCTION........................................................................................................................................3 HISTORICAL BACKGROUND..........................................................................................................4 CENTRAL SUPPORT SERVICES....................................................................................................5 FUNDING.........................................................................................................................................................5 RETREAT............................................................................................................................................................5 RESEARCH GROUPS.........................................................................................................6 MEMBERS OF THE INSTITUTE................................................................................44 CATEGORIES OF APPOINTMENT..............................................................................44 POSTGRADUATE OPPORTUNITIES..........................................................................44 SENIOR GROUP LEADERS.............................................................................................44 GROUP LEADERS.......................................................................................................................48 -
FOI Ref 6871 Response Sent 17 March Can You Please Provide The
FOI Ref 6871 Response sent 17 March Can you please provide the following details from the most recent records which you hold under The Licensing Act 2003: On-trade alcohol licensed premises, including: Premises Licence Number Date Issued Premises Licence Status (active, expired etc.) Premises Name Premises Address Premises Postcode Premises Telephone Number Premises on-trade Category (e.g. Cafe, Bar, Theatre, Nightclub etc.) Premises Licence Holder Name Premises Licence Holder Address Premises Licence Holder Postcode Designated Premises Supervisor Name Designated Premises Supervisor Address Designated Premises Supervisor Postcode The information you have requested is held and in the attached. However the personal information relating to Designated Premises Supervisors you have requested is refused under the exemption to disclosure at Section 40(2) of the Act Further queries on this matter should be directed to [email protected] Full address Telephone number Licence type Status Date issued Licence holder 1 and 1 Rougamo Ltd, 84 Regent Street, Cambridge, 07730029914 Premises Licence Current Licence 10/03/2020 Yao Qin Cambridgeshire, CB2 1DP 2648 Cambridge, 14A Trinity Street, Cambridge, 01223 506090 Premises Licence Current Registration 03/10/2005 The New Vaults Limited Cambridgeshire, CB2 1TB 2nd View Cafe - Waterstones, 20-22 Sidney Street, Premises Licence Current Registration 17/09/2010 Waterstones Booksellers Ltd Cambridge, Cambridgeshire, CB2 3HG ADC Theatre, Park Street, Cambridge, Cambridgeshire, CB5 01223 359547 Premises Licence -
Gurdon Institute 2010 PROSPECTUS / ANNUAL REPORT 2009
The Wellcome Trust/Cancer Research UK Gurdon Institute 2010 PROSPECTUS / ANNUAL REPORT 2009 Gurdon I N S T I T U T E PROSPECTUS 2010 ANNUAL REPORT 2009 http://www.gurdon.cam.ac.uk THE GURDON INSTITUTE 1 CONTENTS THE INSTITUTE IN 2009 INTRODUCTION....................................................................................................................3 HISTORICAL BACKGROUND..........................................................................................................4 CENTRAL SUPPORT SERVICES....................................................................................................4 FUNDING...........................................................................................................................................4 RETREAT.................................................................................................................................................5 RESEARCH GROUPS.........................................................................................................6 MEMBERS OF THE INSTITUTE................................................................................38 CATEGORIES OF APPOINTMENT..............................................................................38 POSTGRADUATE OPPORTUNITIES..........................................................................38 SENIOR GROUP LEADERS.............................................................................................38 GROUP LEADERS.......................................................................................................................45 -
Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6
Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6 The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Lee, Joo-Hyeon et al. “Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6.” Cell 170, 6 (September 2017): 1149–1163 © 2017 The Authors As Published http://dx.doi.org/10.1016/J.CELL.2017.07.028 Publisher Elsevier BV Version Final published version Citable link http://hdl.handle.net/1721.1/116555 Terms of Use Creative Commons Attribution 4.0 International License Detailed Terms http://creativecommons.org/licenses/by/4.0/ Article Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6 Graphical Abstract Authors Joo-Hyeon Lee, Tuomas Tammela, Matan Hofree, ..., Tyler Jacks, Aviv Regev, Carla F. Kim Correspondence [email protected] (J.-H.L.), [email protected] (C.F.K.) In Brief Heterogeneous mesenchymal cell populations in the lung play a central role in epithelial maintenance and alveolar differentiation. Highlights d Lgr5 and Lgr6 mark mesenchymal cells in adult lungs d Single-cell transcriptome analysis defines mesenchymal heterogeneity d Distinct mesenchymal niches drive airway and alveolar differentiation d Wnt activity affects epithelial differentiation specified by mesenchymal cells Lee et al., 2017, Cell 170, 1149–1163 September 7, 2017 ª 2017 The Authors. Published by Elsevier Inc. http://dx.doi.org/10.1016/j.cell.2017.07.028 Article Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6 Joo-Hyeon Lee,1,2,3,4,5,* Tuomas Tammela,6 Matan Hofree,7 Jinwook Choi,4 Nemanja Despot Marjanovic,6 Seungmin Han,4,8 David Canner,6 Katherine Wu,6 Margherita Paschini,1,2,3 Dong Ha Bhang,9 Tyler Jacks,6,10 Aviv Regev,6,7,10 and Carla F. -
Mechanistic Insights and Identification of Two Novel Factors in the C
Downloaded from genesdev.cshlp.org on September 24, 2021 - Published by Cold Spring Harbor Laboratory Press Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway Dasa Longman,1 Ronald H.A. Plasterk,2 Iain L. Johnstone,3 and Javier F. Cáceres1,4 1Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom; 2Hubrecht Laboratory-Koninklijke Nederlandse Akademie van Wetenschappen (KNAW), 3584 CT Utrecht, The Netherlands; 3Institute of Biomedical and Life Sciences, Division of Molecular Genetics, University of Glasgow, Anderson College, Glasgow G11 6NU, Scotland, United Kingdom The nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs). Seven genes (smg-1–7, for suppressor with morphological effect on genitalia) that are essential for NMD were originally identified in the nematode Caenorhabditis elegans, and orthologs of these genes have been found in several species. Whereas in humans NMD is linked to splicing, PTC definition occurs independently of exon boundaries in Drosophila. Here, we have conducted an analysis of the cis-acting sequences and trans-acting factors that are required for NMD in C. elegans. We show that a PTC codon is defined independently of introns in C. elegans and, consequently, components of the exon junction complex (EJC) are dispensable for NMD. We also show a distance-dependent effect, whereby PTCs that are closer to the 3 end of the mRNA are less sensitive to NMD. We also provide evidence for the existence of previously unidentified components of the NMD pathway that, unlike known smg genes, are essential for viability in C. -
Tick-Borne Pathogens and Diseases in Greece
microorganisms Review Tick-Borne Pathogens and Diseases in Greece Artemis Efstratiou 1,†, Gabriele Karanis 2 and Panagiotis Karanis 3,4,* 1 National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan; [email protected] 2 Orthopädische Rehabilitationsklinik, Eisenmoorbad Bad Schmiedeberg Kur GmbH, 06905 Bad Schmiedeberg, Germany; [email protected] 3 Medical Faculty and University Hospital, The University of Cologne, 50923 Cologne, Germany 4 Department of Basic and Clinical Sciences, University of Nicosia Medical School, 21 Ilia Papakyriakou, 2414 Engomi. P.O. Box 24005, Nicosia CY-1700, Cyprus * Correspondence: [email protected] † Current address: Max-Planck Institute for Evolutionary Biology, 24306 Plön, Germany. Abstract: Tick-borne diseases (TBDs) are recognized as a serious and growing public health epidemic in Europe, and are a cause of major losses in livestock production worldwide. This review is an attempt to present a summary of results from studies conducted over the last century until the end of the year 2020 regarding ticks, tick-borne pathogens, and tick-borne diseases in Greece. We provide an overview of the tick species found in Greece, as well as the most important tick-borne pathogens (viruses, bacteria, protozoa) and corresponding diseases in circulation. We also consider prevalence data, as well as geographic and climatic conditions. Knowledge of past and current situations of TBDs, as well as an awareness of (risk) factors affecting future developments will help to find approaches to integrated tick management as part of the ‘One Health Concept’; it will assist in avoiding the possibility of hotspot disease emergencies and intra- and intercontinental transmission. -
A Brief History of Christ Church
A Brief History of Christ Church MEDIEVAL PERIOD Christ Church was founded in 1546, and there had been a college here since 1525, but prior to the dissolution of the monasteries, the site was occupied by a priory dedicated to the memory of St Frideswide, the patron saint of both university and city. St Frideswide, a noble Saxon lady, founded a nunnery for herself as head and for twelve more noble virgin ladies sometime towards the end of the seventh century. She was, however, pursued by Algar, prince of Leicester, for her hand in marriage. She refused his frequent approaches which became more and more desperate. Frideswide and her ladies, forewarned miraculously of yet another attempt by Algar, fled up river to hide. She stayed away some years, settling at Binsey, where she performed healing miracles. On returning to Oxford, Frideswide found that Algar was as persistent as ever, laying siege to the town in order to capture his bride. Frideswide called down blindness on Algar who eventually repented of his ways, and left Frideswide to her devotions. Frideswide died in about 737, and was canonised in 1480. Long before this, though, pilgrims came to her shrine in the priory church which was now populated by Augustinian canons. Nothing remains of Frideswide’s nunnery, and little of the Saxon church - perhaps a few stones - but the cathedral and the buildings around the cloister are the oldest on the site. Her story is pictured in cartoon form by Burne-Jones in one of the windows in the cathedral. One of the gifts made to the priory was the meadow between Christ Church and the river; Lady Montacute gave the land to maintain her chantry which lay in the Lady Chapel close to St Frideswide’s shrine. -
(Soft) Ticks (Acari: Parasitiformes: Argasidae) in Relation to Transmission of Human Pathogens
International Journal of Vaccines and Vaccination Status of Argasid (Soft) Ticks (Acari: Parasitiformes: Argasidae) In Relation To Transmission of Human Pathogens Abstract Review Article Ticks transmit a greater variety of infectious agents than any other arthropod group, Volume 4 Issue 4 - 2017 in fact, these are second only to mosquitoes as carriers of human pathogens. This article concerns to the different ticks as vectors of parasites and their control methods having a major focus on vaccines against pathogens. Typically, argasids do not possess Department of Entomology, Nuclear Institute for Food & a dorsal shield or scutum, their capitulum is less prominent and ventrally instead Agriculture (NIFA), Pakistan anteriorly located, coxae are unarmed (without spurs), and spiracular plates small. A number of genera and species of ticks in the families Argasidae (soft ticks) are of public *Corresponding author: Muhammad Sarwar, Department health importance. Certain species of argasid ticks of the genera Argas, Ornithodoros, of Entomology, Nuclear Institute for Food & Agriculture Carios and Otobius are important in the transmission of many human’s pathogens. (NIFA), Pakistan, Email: Moreover, argasids have multi-host life cycles and two or more nymphal stages each requiring a blood meal from a host. Unlike the ixodid (hard) ticks, which stay attached Received: December 11, 2016 | Published: September 21, to their hosts for up to several days while feeding, most argasids are adapted to feed 2017 rapidly (for about an hour) and then dropping off the host. They transmit a variety of pathogens of medical and veterinary interest, including viruses, bacteria, rickettsiae, helminthes, and protozoans, all of which are able to cause damage to livestock production and human health.