molecular spectroscopy

DXR Raman Microscope

Precision Raman Microscopy

Point-and-shoot Raman microscopy

Exceptional spatial resolution

Powerful analytical tool focused on results

Three excitation laser frequencies

Part of Thermo Fisher Scientific FOCUS ON RESULTS – DXR RAMAN MICROSCOPE

Packaging Forensics Fibers Gems/Geology Art Restoration Nanotechnology

The DXR Raman microscope delivers uncompromising 1-micron spatial resolution and true confocal depth profiling for the most demanding analytical challenges. DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 2

ANSWERS YOU CAN TRUST THE RAMAN MICROSCOPE DESIGNED WITH YOU IN MIND

Results Made Easy From the Experts in Raman Microscopy

The DXR Raman microscope lets the user focus on the results, not on learning new techniques With many years of experience in Raman and Unlock the power of Raman microscopy, effortlessly… FT-IR microscopy, Thermo Fisher Scientific Your Applications and Raman Microscopy and procedures. At Thermo Scientific, we design instruments that take care of the details. has designed the DXR Raman microscope You are going to find yourself relying on your Raman microscopy is of critical value in industrial and to encompass all the benefits of Raman DXR Raman microscope for many of your most non-industrial environments alike. New applications microscopy in one simple, easy-to-use challenging applications. For small particle analysis, are being discovered daily in: Top Quality Results Made Easy – instrument. The DXR Raman microscope the 1-micron spatial resolution is invaluable. In • Dyes and Chemicals • Fibers unique software features optimize signal-to-noise includes patented technology to take Patent addition, the DXR Raman microscope gives you • Pharmaceuticals • Nanotechnology to reveal even the finest details in a spectrum of Pending the guesswork out of achieving optimal true confocal depth profiling abilities, enabling • Packaging • Polymers Tyrian Purple pigment. performance – routinely and reproducibly. you to look for evidence of inclusions or impurities • Paper Manufacturing • Forensics This is the Raman microscope that the busy and characterize multi-layer polymer films. • Gemstones • Geology analytical lab cannot afford to be without. • Art Restoration and the Study of Cultural Artifacts Raman provides many benefits: Raman microscopy is employed at many stages in the Autofocus – • Rapid and non destructive manufacturing process from research to final product QC: optimizes the focus to • No sample preparation • Methods Development • R & D maximize the Raman • No water interference – easy to measure aqueous samples • QA/QC • Reverse Engineering signal automatically. • Complementary to FT-IR • Failure and Defect Analysis • Easy access to low vibrational frequencies, Smart making it easy to analyze inorganic molecules Background – Automatic Fluorescence Correction – the DXR Raman automatically corrects for fluorescence interference. microscope collects Available for all excitation lasers. background data The DXR Raman Microscope during instrument The DXR Raman microscope is a research-quality tool designed specifically for today’s multi-purpose downtime, so that analytical labs. This is the microscope for the user who needs the high spatial resolution, ease of the user never sample preparation and power of Raman microscopy, and who has neither the time nor the desire • Patented autoalignment has to wait. to become a Raman expert. The DXR Raman microscope delivers spatial system for guaranteed optimal performance resolution that is as good or better than any instrument on the market, • True point-and-shoot Raman together with unique features designed to make it as easy as Autoexposure – the DXR Raman capability possible to get high quality results. microscope calculates the exposure time and • Exceptional spatial resolution number of exposures for optimal sensitivity. • Superb visual quality

Laser Power Regulator – compensates for Automatic Intensity Correction – changes in laser power output and guarantees consistent compensates for detector wavelength dependence. Raman response. Legend: Zone A: The Laser Power Regulator controls the laser power reaching the sample to ensure reproducible results. Zone B: As the laser power declines over its lifetime, measurements become non-reproducible on instruments lacking a Laser Power Regulator. Zone C: Beyond the expected laser lifetime. The DXR Raman microscope can still be used reproducibly at lower power levels, however the laser should be replaced in order to obtain maximum power output. DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 2

ANSWERS YOU CAN TRUST THE RAMAN MICROSCOPE DESIGNED WITH YOU IN MIND

Results Made Easy From the Experts in Raman Microscopy

The DXR Raman microscope lets the user focus on the results, not on learning new techniques With many years of experience in Raman and Unlock the power of Raman microscopy, effortlessly… FT-IR microscopy, Thermo Fisher Scientific Your Applications and Raman Microscopy and procedures. At Thermo Scientific, we design instruments that take care of the details. has designed the DXR Raman microscope You are going to find yourself relying on your Raman microscopy is of critical value in industrial and to encompass all the benefits of Raman DXR Raman microscope for many of your most non-industrial environments alike. New applications microscopy in one simple, easy-to-use challenging applications. For small particle analysis, are being discovered daily in: Top Quality Results Made Easy – instrument. The DXR Raman microscope the 1-micron spatial resolution is invaluable. In • Dyes and Chemicals • Fibers unique software features optimize signal-to-noise includes patented technology to take Patent addition, the DXR Raman microscope gives you • Pharmaceuticals • Nanotechnology to reveal even the finest details in a spectrum of Pending the guesswork out of achieving optimal true confocal depth profiling abilities, enabling • Packaging • Polymers Tyrian Purple pigment. performance – routinely and reproducibly. you to look for evidence of inclusions or impurities • Paper Manufacturing • Forensics This is the Raman microscope that the busy and characterize multi-layer polymer films. • Gemstones • Geology analytical lab cannot afford to be without. • Art Restoration and the Study of Cultural Artifacts Raman provides many benefits: Raman microscopy is employed at many stages in the Autofocus – • Rapid and non destructive manufacturing process from research to final product QC: optimizes the focus to • No sample preparation • Methods Development • R & D maximize the Raman • No water interference – easy to measure aqueous samples • QA/QC • Reverse Engineering signal automatically. • Complementary to FT-IR • Failure and Defect Analysis • Easy access to low vibrational frequencies, Smart making it easy to analyze inorganic molecules Background – Automatic Fluorescence Correction – the DXR Raman automatically corrects for fluorescence interference. microscope collects Available for all excitation lasers. background data The DXR Raman Microscope during instrument The DXR Raman microscope is a research-quality tool designed specifically for today’s multi-purpose downtime, so that analytical labs. This is the microscope for the user who needs the high spatial resolution, ease of the user never sample preparation and power of Raman microscopy, and who has neither the time nor the desire • Patented autoalignment has to wait. to become a Raman expert. The DXR Raman microscope delivers spatial system for guaranteed optimal performance resolution that is as good or better than any instrument on the market, • True point-and-shoot Raman together with unique features designed to make it as easy as Autoexposure – the DXR Raman capability possible to get high quality results. microscope calculates the exposure time and • Exceptional spatial resolution number of exposures for optimal sensitivity. • Superb visual quality

Laser Power Regulator – compensates for Automatic Intensity Correction – changes in laser power output and guarantees consistent compensates for detector wavelength dependence. Raman response. Legend: Zone A: The Laser Power Regulator controls the laser power reaching the sample to ensure reproducible results. Zone B: As the laser power declines over its lifetime, measurements become non-reproducible on instruments lacking a Laser Power Regulator. Zone C: Beyond the expected laser lifetime. The DXR Raman microscope can still be used reproducibly at lower power levels, however the laser should be replaced in order to obtain maximum power output. DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 2

ANSWERS YOU CAN TRUST THE RAMAN MICROSCOPE DESIGNED WITH YOU IN MIND

Results Made Easy From the Experts in Raman Microscopy

The DXR Raman microscope lets the user focus on the results, not on learning new techniques With many years of experience in Raman and Unlock the power of Raman microscopy, effortlessly… FT-IR microscopy, Thermo Fisher Scientific Your Applications and Raman Microscopy and procedures. At Thermo Scientific, we design instruments that take care of the details. has designed the DXR Raman microscope You are going to find yourself relying on your Raman microscopy is of critical value in industrial and to encompass all the benefits of Raman DXR Raman microscope for many of your most non-industrial environments alike. New applications microscopy in one simple, easy-to-use challenging applications. For small particle analysis, are being discovered daily in: Top Quality Results Made Easy – instrument. The DXR Raman microscope the 1-micron spatial resolution is invaluable. In • Dyes and Chemicals • Fibers unique software features optimize signal-to-noise includes patented technology to take Patent addition, the DXR Raman microscope gives you • Pharmaceuticals • Nanotechnology to reveal even the finest details in a spectrum of Pending the guesswork out of achieving optimal true confocal depth profiling abilities, enabling • Packaging • Polymers Tyrian Purple pigment. performance – routinely and reproducibly. you to look for evidence of inclusions or impurities • Paper Manufacturing • Forensics This is the Raman microscope that the busy and characterize multi-layer polymer films. • Gemstones • Geology analytical lab cannot afford to be without. • Art Restoration and the Study of Cultural Artifacts Raman provides many benefits: Raman microscopy is employed at many stages in the Autofocus – • Rapid and non destructive manufacturing process from research to final product QC: optimizes the focus to • No sample preparation • Methods Development • R & D maximize the Raman • No water interference – easy to measure aqueous samples • QA/QC • Reverse Engineering signal automatically. • Complementary to FT-IR • Failure and Defect Analysis • Easy access to low vibrational frequencies, Smart making it easy to analyze inorganic molecules Background – Automatic Fluorescence Correction – the DXR Raman automatically corrects for fluorescence interference. microscope collects Available for all excitation lasers. background data The DXR Raman Microscope during instrument The DXR Raman microscope is a research-quality tool designed specifically for today’s multi-purpose downtime, so that analytical labs. This is the microscope for the user who needs the high spatial resolution, ease of the user never sample preparation and power of Raman microscopy, and who has neither the time nor the desire • Patented autoalignment has to wait. to become a Raman expert. The DXR Raman microscope delivers spatial system for guaranteed optimal performance resolution that is as good or better than any instrument on the market, • True point-and-shoot Raman together with unique features designed to make it as easy as Autoexposure – the DXR Raman capability possible to get high quality results. microscope calculates the exposure time and • Exceptional spatial resolution number of exposures for optimal sensitivity. • Superb visual quality

Laser Power Regulator – compensates for Automatic Intensity Correction – changes in laser power output and guarantees consistent compensates for detector wavelength dependence. Raman response. Legend: Zone A: The Laser Power Regulator controls the laser power reaching the sample to ensure reproducible results. Zone B: As the laser power declines over its lifetime, measurements become non-reproducible on instruments lacking a Laser Power Regulator. Zone C: Beyond the expected laser lifetime. The DXR Raman microscope can still be used reproducibly at lower power levels, however the laser should be replaced in order to obtain maximum power output. DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 1

PERFORMANCE WITHOUT COMPROMISE SIMPLY THE BEST

Raman Spectrometer • Class I laser safe; safe to use in the open lab (Class IIIb optional) The Performance You Need Invaluable – Now and into the Future Effortless Maintenance • 532-, 633- and 780-nm high-brightness lasers; factory aligned, user-interchangeable The DXR Raman microscope is designed from start to finish as a robust analytical tool. The DXR Raman microscope is the platform that expands to meet your changing needs. A fully calibrated and aligned instrument delivers reproducible results dependably. With its • Convenient storage container for additional lasers, gratings and filters • Spectrometer with no moving parts for dependable performance This means no compromises on the performance features that matter. deceptively simple design and minimal moving parts, the DXR Raman microscope is easy to • Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1, maintain. Patented autoalignment, calibration and other features make it easy to incorporate 5 cm-1 spectral resolution* High Brightness Lasers – routine instrument maintenance into standard lab operating procedures. • High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1 Precision Fiber optics for remote sampling a focus all of the laser energy (fingerprint region) on the target for better DIC and fluorescence for greater • SmartLock technology for reproducibly mounting lasers, gratings, filters, fiber port contrast and no wasted flexibility in sample imaging b • Smart components report identity and serial numbers for compatibility checking, laser power. The absence traceability and laser lifetime tracking of scatter from material Pre-aligned Smart Components – factory-aligned components permit lasers, • Patented Autoalignment procedure to ensure optimal alignment and precision sampling surrounding the target gratings and filters to be exchanged easily. • Rapid automated calibration to ensure validity of results guarantees true confocality. Lasers, gratings, filters, fiber launcher identify themselves by serial Low Brightness High Brightness • Laser Power Regulator Choice of Spectral Resolution – number and wavelength. OMNIC software checks for component compatibility. -1 -1 choose standard spectral resolution * Spectral range for the 780 nm excitation laser is 50 cm to 3300 cm c for routine analysis. For hard-to- resolve bands high resolution gratings Sampling are available for all three lasers. Easy-to-maintain • Software-controlled motorized microscope stage for automated data collection Spectrograph – and sample mapping (manual stage optional) no moving parts, unique • Multi-well adapter for automated multi-well plate sampling Exceptional Spatial Resolution – design optimizes perform- • Spacious microscope stage compartment for large samples, heated, cooled analyze the smallest sample features with confidence. ance at all wavelengths. and other specialty stages (a) and (b): SEM of spatial resolution target and Raman User-replaceable Components – • Optional tube and vial sampling accessory map, respectively; (c) cross-section of the Raman map, no service calls required to replace a laser. demonstrating better than 1-micron resolution. • Fiber optic probe sampling option Smart Lasers – automatically track laser lifetime. Software Add objectives for additional versatility Patented • Comprehensive OMNIC software suite for full instrument control and data processing Fully Automated Confocal Microscopy – Autoalignment – Switch to brightfield • OMNIC Array Automation provides automated data collection from sample arrays Patented 2-micron resolution for depth profiling and inclusion keeps the excitation laser, Raman Scatter or darkfield and post-collection data processing Autoalignment – analysis. Depth profile of food packaging. illumination the Raman scattering, • OMNIC Atlµs™ software permits sample mapping and image analysis precision sampling and the visual light paths Excitation Laser ™ with minimum Superior Visual Imaging precisely aligned to the • TQ Analyst with chemometrics for comprehensive data analysis Multiple Lasers – Be ready for any sample. Expand the interference from same sampling point • Extensive Raman libraries and easy to use search capabilities capabilities of the DXR Raman microscope by adding a second surrounding for maximum sampling or third excitation laser. Minimize fluorescence interference, or materials. precision. No manual Light Microscope Visual Light Path Visual

Visual Light Path Visual enhance sensitivity by up to 10-fold. Facilities with more than alignment necessary. • Research grade microscope one DXR microscope or SmartRaman can share lasers, gratings • 4X, 10X, 20X, 50X and 100X microscope objectives, with brightfield/darkfield, • Trinocular and filters between instruments for even greater versatility. oil immersion, and long working distance options • Full range of Olympus microscope options Components are automatically recognized by Smart technology and pre-aligned so there is no need for a service call. • Standard and brightfield/darkfield illuminators • Fluorescence and DIC light microscopy options SmartLock Technology for Reproducible Results • Digital video camera for video data capture • Trinocular for visual and video imaging (binocular or video only optional) SmartLock Filters SmartLock Grating Ensures reproducible spectra even with multiple Users can configure the DXR Raman microscope grating exchanges (plot shows an overlay of 150 Maintenance spectra; grating exchanged between each collect). with up to three different excitation wave- Single USB Connection – • Single beam-path spectrometer for robustness and simple alignment lengths – at 532, 633 and 780 nm. The lasers, full instrument control from • Spectrograph with no moving parts for high reliability together with the appropriate filters and either a desktop or laptop • Minimal service requirements gratings, lock into place using SmartLock computer through a single • All consumables, including lasers, are technology for precisely reproducible results. USB port. Laser Power Regulator – user-replaceable OMNIC™ software recognizes each component, compensates for changes • Software-controlled alignment and calibration records the serial numbers and checks for Automated Calibration – spectrograph, laser and Raman in laser power output and performed routinely by the user compatibility. A convenient storage container intensity calibrations are completely automated by OMNIC software guarantees consistent power Fine-adjust Mirrors – software-controlled mirror is provided for when the components are not using standards located in the alignment/calibration tool. at the sample. Validation SmartLock Lasers adjustments to maintain peak performance. ™ in use. • ValPro System Qualification package for full validation to meet all regulatory requirements DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 1

PERFORMANCE WITHOUT COMPROMISE SIMPLY THE BEST

Raman Spectrometer • Class I laser safe; safe to use in the open lab (Class IIIb optional) The Performance You Need Invaluable – Now and into the Future Effortless Maintenance • 532-, 633- and 780-nm high-brightness lasers; factory aligned, user-interchangeable The DXR Raman microscope is designed from start to finish as a robust analytical tool. The DXR Raman microscope is the platform that expands to meet your changing needs. A fully calibrated and aligned instrument delivers reproducible results dependably. With its • Convenient storage container for additional lasers, gratings and filters • Spectrometer with no moving parts for dependable performance This means no compromises on the performance features that matter. deceptively simple design and minimal moving parts, the DXR Raman microscope is easy to • Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1, maintain. Patented autoalignment, calibration and other features make it easy to incorporate 5 cm-1 spectral resolution* High Brightness Lasers – routine instrument maintenance into standard lab operating procedures. • High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1 Precision Fiber optics for remote sampling a focus all of the laser energy (fingerprint region) on the target for better DIC and fluorescence for greater • SmartLock technology for reproducibly mounting lasers, gratings, filters, fiber port contrast and no wasted flexibility in sample imaging b • Smart components report identity and serial numbers for compatibility checking, laser power. The absence traceability and laser lifetime tracking of scatter from material Pre-aligned Smart Components – factory-aligned components permit lasers, • Patented Autoalignment procedure to ensure optimal alignment and precision sampling surrounding the target gratings and filters to be exchanged easily. • Rapid automated calibration to ensure validity of results guarantees true confocality. Lasers, gratings, filters, fiber launcher identify themselves by serial Low Brightness High Brightness • Laser Power Regulator Choice of Spectral Resolution – number and wavelength. OMNIC software checks for component compatibility. -1 -1 choose standard spectral resolution * Spectral range for the 780 nm excitation laser is 50 cm to 3300 cm c for routine analysis. For hard-to- resolve bands high resolution gratings Sampling are available for all three lasers. Easy-to-maintain • Software-controlled motorized microscope stage for automated data collection Spectrograph – and sample mapping (manual stage optional) no moving parts, unique • Multi-well adapter for automated multi-well plate sampling Exceptional Spatial Resolution – design optimizes perform- • Spacious microscope stage compartment for large samples, heated, cooled analyze the smallest sample features with confidence. ance at all wavelengths. and other specialty stages (a) and (b): SEM of spatial resolution target and Raman User-replaceable Components – • Optional tube and vial sampling accessory map, respectively; (c) cross-section of the Raman map, no service calls required to replace a laser. demonstrating better than 1-micron resolution. • Fiber optic probe sampling option Smart Lasers – automatically track laser lifetime. Software Add objectives for additional versatility Patented • Comprehensive OMNIC software suite for full instrument control and data processing Fully Automated Confocal Microscopy – Autoalignment – Switch to brightfield • OMNIC Array Automation provides automated data collection from sample arrays Patented 2-micron resolution for depth profiling and inclusion keeps the excitation laser, Raman Scatter or darkfield and post-collection data processing Autoalignment – analysis. Depth profile of food packaging. illumination the Raman scattering, • OMNIC Atlµs™ software permits sample mapping and image analysis precision sampling and the visual light paths Excitation Laser ™ with minimum Superior Visual Imaging precisely aligned to the • TQ Analyst with chemometrics for comprehensive data analysis Multiple Lasers – Be ready for any sample. Expand the interference from same sampling point • Extensive Raman libraries and easy to use search capabilities capabilities of the DXR Raman microscope by adding a second surrounding for maximum sampling or third excitation laser. Minimize fluorescence interference, or materials. precision. No manual Light Microscope Visual Light Path Visual

Visual Light Path Visual enhance sensitivity by up to 10-fold. Facilities with more than alignment necessary. • Research grade microscope one DXR microscope or SmartRaman can share lasers, gratings • 4X, 10X, 20X, 50X and 100X microscope objectives, with brightfield/darkfield, • Trinocular and filters between instruments for even greater versatility. oil immersion, and long working distance options • Full range of Olympus microscope options Components are automatically recognized by Smart technology and pre-aligned so there is no need for a service call. • Standard and brightfield/darkfield illuminators • Fluorescence and DIC light microscopy options SmartLock Technology for Reproducible Results • Digital video camera for video data capture • Trinocular for visual and video imaging (binocular or video only optional) SmartLock Filters SmartLock Grating Ensures reproducible spectra even with multiple Users can configure the DXR Raman microscope grating exchanges (plot shows an overlay of 150 Maintenance spectra; grating exchanged between each collect). with up to three different excitation wave- Single USB Connection – • Single beam-path spectrometer for robustness and simple alignment lengths – at 532, 633 and 780 nm. The lasers, full instrument control from • Spectrograph with no moving parts for high reliability together with the appropriate filters and either a desktop or laptop • Minimal service requirements gratings, lock into place using SmartLock computer through a single • All consumables, including lasers, are technology for precisely reproducible results. USB port. Laser Power Regulator – user-replaceable OMNIC™ software recognizes each component, compensates for changes • Software-controlled alignment and calibration records the serial numbers and checks for Automated Calibration – spectrograph, laser and Raman in laser power output and performed routinely by the user compatibility. A convenient storage container intensity calibrations are completely automated by OMNIC software guarantees consistent power Fine-adjust Mirrors – software-controlled mirror is provided for when the components are not using standards located in the alignment/calibration tool. at the sample. Validation SmartLock Lasers adjustments to maintain peak performance. ™ in use. • ValPro System Qualification package for full validation to meet all regulatory requirements DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 1

PERFORMANCE WITHOUT COMPROMISE SIMPLY THE BEST

Raman Spectrometer • Class I laser safe; safe to use in the open lab (Class IIIb optional) The Performance You Need Invaluable – Now and into the Future Effortless Maintenance • 532-, 633- and 780-nm high-brightness lasers; factory aligned, user-interchangeable The DXR Raman microscope is designed from start to finish as a robust analytical tool. The DXR Raman microscope is the platform that expands to meet your changing needs. A fully calibrated and aligned instrument delivers reproducible results dependably. With its • Convenient storage container for additional lasers, gratings and filters • Spectrometer with no moving parts for dependable performance This means no compromises on the performance features that matter. deceptively simple design and minimal moving parts, the DXR Raman microscope is easy to • Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1, maintain. Patented autoalignment, calibration and other features make it easy to incorporate 5 cm-1 spectral resolution* High Brightness Lasers – routine instrument maintenance into standard lab operating procedures. • High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1 Precision Fiber optics for remote sampling a focus all of the laser energy (fingerprint region) on the target for better DIC and fluorescence for greater • SmartLock technology for reproducibly mounting lasers, gratings, filters, fiber port contrast and no wasted flexibility in sample imaging b • Smart components report identity and serial numbers for compatibility checking, laser power. The absence traceability and laser lifetime tracking of scatter from material Pre-aligned Smart Components – factory-aligned components permit lasers, • Patented Autoalignment procedure to ensure optimal alignment and precision sampling surrounding the target gratings and filters to be exchanged easily. • Rapid automated calibration to ensure validity of results guarantees true confocality. Lasers, gratings, filters, fiber launcher identify themselves by serial Low Brightness High Brightness • Laser Power Regulator Choice of Spectral Resolution – number and wavelength. OMNIC software checks for component compatibility. -1 -1 choose standard spectral resolution * Spectral range for the 780 nm excitation laser is 50 cm to 3300 cm c for routine analysis. For hard-to- resolve bands high resolution gratings Sampling are available for all three lasers. Easy-to-maintain • Software-controlled motorized microscope stage for automated data collection Spectrograph – and sample mapping (manual stage optional) no moving parts, unique • Multi-well adapter for automated multi-well plate sampling Exceptional Spatial Resolution – design optimizes perform- • Spacious microscope stage compartment for large samples, heated, cooled analyze the smallest sample features with confidence. ance at all wavelengths. and other specialty stages (a) and (b): SEM of spatial resolution target and Raman User-replaceable Components – • Optional tube and vial sampling accessory map, respectively; (c) cross-section of the Raman map, no service calls required to replace a laser. demonstrating better than 1-micron resolution. • Fiber optic probe sampling option Smart Lasers – automatically track laser lifetime. Software Add objectives for additional versatility Patented • Comprehensive OMNIC software suite for full instrument control and data processing Fully Automated Confocal Microscopy – Autoalignment – Switch to brightfield • OMNIC Array Automation provides automated data collection from sample arrays Patented 2-micron resolution for depth profiling and inclusion keeps the excitation laser, Raman Scatter or darkfield and post-collection data processing Autoalignment – analysis. Depth profile of food packaging. illumination the Raman scattering, • OMNIC Atlµs™ software permits sample mapping and image analysis precision sampling and the visual light paths Excitation Laser ™ with minimum Superior Visual Imaging precisely aligned to the • TQ Analyst with chemometrics for comprehensive data analysis Multiple Lasers – Be ready for any sample. Expand the interference from same sampling point • Extensive Raman libraries and easy to use search capabilities capabilities of the DXR Raman microscope by adding a second surrounding for maximum sampling or third excitation laser. Minimize fluorescence interference, or materials. precision. No manual Light Microscope Visual Light Path Visual

Visual Light Path Visual enhance sensitivity by up to 10-fold. Facilities with more than alignment necessary. • Research grade microscope one DXR microscope or SmartRaman can share lasers, gratings • 4X, 10X, 20X, 50X and 100X microscope objectives, with brightfield/darkfield, • Trinocular and filters between instruments for even greater versatility. oil immersion, and long working distance options • Full range of Olympus microscope options Components are automatically recognized by Smart technology and pre-aligned so there is no need for a service call. • Standard and brightfield/darkfield illuminators • Fluorescence and DIC light microscopy options SmartLock Technology for Reproducible Results • Digital video camera for video data capture • Trinocular for visual and video imaging (binocular or video only optional) SmartLock Filters SmartLock Grating Ensures reproducible spectra even with multiple Users can configure the DXR Raman microscope grating exchanges (plot shows an overlay of 150 Maintenance spectra; grating exchanged between each collect). with up to three different excitation wave- Single USB Connection – • Single beam-path spectrometer for robustness and simple alignment lengths – at 532, 633 and 780 nm. The lasers, full instrument control from • Spectrograph with no moving parts for high reliability together with the appropriate filters and either a desktop or laptop • Minimal service requirements gratings, lock into place using SmartLock computer through a single • All consumables, including lasers, are technology for precisely reproducible results. USB port. Laser Power Regulator – user-replaceable OMNIC™ software recognizes each component, compensates for changes • Software-controlled alignment and calibration records the serial numbers and checks for Automated Calibration – spectrograph, laser and Raman in laser power output and performed routinely by the user compatibility. A convenient storage container intensity calibrations are completely automated by OMNIC software guarantees consistent power Fine-adjust Mirrors – software-controlled mirror is provided for when the components are not using standards located in the alignment/calibration tool. at the sample. Validation SmartLock Lasers adjustments to maintain peak performance. ™ in use. • ValPro System Qualification package for full validation to meet all regulatory requirements DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 1

PERFORMANCE WITHOUT COMPROMISE SIMPLY THE BEST

Raman Spectrometer • Class I laser safe; safe to use in the open lab (Class IIIb optional) The Performance You Need Invaluable – Now and into the Future Effortless Maintenance • 532-, 633- and 780-nm high-brightness lasers; factory aligned, user-interchangeable The DXR Raman microscope is designed from start to finish as a robust analytical tool. The DXR Raman microscope is the platform that expands to meet your changing needs. A fully calibrated and aligned instrument delivers reproducible results dependably. With its • Convenient storage container for additional lasers, gratings and filters • Spectrometer with no moving parts for dependable performance This means no compromises on the performance features that matter. deceptively simple design and minimal moving parts, the DXR Raman microscope is easy to • Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1, maintain. Patented autoalignment, calibration and other features make it easy to incorporate 5 cm-1 spectral resolution* High Brightness Lasers – routine instrument maintenance into standard lab operating procedures. • High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1 Precision Fiber optics for remote sampling a focus all of the laser energy (fingerprint region) on the target for better DIC and fluorescence for greater • SmartLock technology for reproducibly mounting lasers, gratings, filters, fiber port contrast and no wasted flexibility in sample imaging b • Smart components report identity and serial numbers for compatibility checking, laser power. The absence traceability and laser lifetime tracking of scatter from material Pre-aligned Smart Components – factory-aligned components permit lasers, • Patented Autoalignment procedure to ensure optimal alignment and precision sampling surrounding the target gratings and filters to be exchanged easily. • Rapid automated calibration to ensure validity of results guarantees true confocality. Lasers, gratings, filters, fiber launcher identify themselves by serial Low Brightness High Brightness • Laser Power Regulator Choice of Spectral Resolution – number and wavelength. OMNIC software checks for component compatibility. -1 -1 choose standard spectral resolution * Spectral range for the 780 nm excitation laser is 50 cm to 3300 cm c for routine analysis. For hard-to- resolve bands high resolution gratings Sampling are available for all three lasers. Easy-to-maintain • Software-controlled motorized microscope stage for automated data collection Spectrograph – and sample mapping (manual stage optional) no moving parts, unique • Multi-well adapter for automated multi-well plate sampling Exceptional Spatial Resolution – design optimizes perform- • Spacious microscope stage compartment for large samples, heated, cooled analyze the smallest sample features with confidence. ance at all wavelengths. and other specialty stages (a) and (b): SEM of spatial resolution target and Raman User-replaceable Components – • Optional tube and vial sampling accessory map, respectively; (c) cross-section of the Raman map, no service calls required to replace a laser. demonstrating better than 1-micron resolution. • Fiber optic probe sampling option Smart Lasers – automatically track laser lifetime. Software Add objectives for additional versatility Patented • Comprehensive OMNIC software suite for full instrument control and data processing Fully Automated Confocal Microscopy – Autoalignment – Switch to brightfield • OMNIC Array Automation provides automated data collection from sample arrays Patented 2-micron resolution for depth profiling and inclusion keeps the excitation laser, Raman Scatter or darkfield and post-collection data processing Autoalignment – analysis. Depth profile of food packaging. illumination the Raman scattering, • OMNIC Atlµs™ software permits sample mapping and image analysis precision sampling and the visual light paths Excitation Laser ™ with minimum Superior Visual Imaging precisely aligned to the • TQ Analyst with chemometrics for comprehensive data analysis Multiple Lasers – Be ready for any sample. Expand the interference from same sampling point • Extensive Raman libraries and easy to use search capabilities capabilities of the DXR Raman microscope by adding a second surrounding for maximum sampling or third excitation laser. Minimize fluorescence interference, or materials. precision. No manual Light Microscope Visual Light Path Visual

Visual Light Path Visual enhance sensitivity by up to 10-fold. Facilities with more than alignment necessary. • Research grade microscope one DXR microscope or SmartRaman can share lasers, gratings • 4X, 10X, 20X, 50X and 100X microscope objectives, with brightfield/darkfield, • Trinocular and filters between instruments for even greater versatility. oil immersion, and long working distance options • Full range of Olympus microscope options Components are automatically recognized by Smart technology and pre-aligned so there is no need for a service call. • Standard and brightfield/darkfield illuminators • Fluorescence and DIC light microscopy options SmartLock Technology for Reproducible Results • Digital video camera for video data capture • Trinocular for visual and video imaging (binocular or video only optional) SmartLock Filters SmartLock Grating Ensures reproducible spectra even with multiple Users can configure the DXR Raman microscope grating exchanges (plot shows an overlay of 150 Maintenance spectra; grating exchanged between each collect). with up to three different excitation wave- Single USB Connection – • Single beam-path spectrometer for robustness and simple alignment lengths – at 532, 633 and 780 nm. The lasers, full instrument control from • Spectrograph with no moving parts for high reliability together with the appropriate filters and either a desktop or laptop • Minimal service requirements gratings, lock into place using SmartLock computer through a single • All consumables, including lasers, are technology for precisely reproducible results. USB port. Laser Power Regulator – user-replaceable OMNIC™ software recognizes each component, compensates for changes • Software-controlled alignment and calibration records the serial numbers and checks for Automated Calibration – spectrograph, laser and Raman in laser power output and performed routinely by the user compatibility. A convenient storage container intensity calibrations are completely automated by OMNIC software guarantees consistent power Fine-adjust Mirrors – software-controlled mirror is provided for when the components are not using standards located in the alignment/calibration tool. at the sample. Validation SmartLock Lasers adjustments to maintain peak performance. ™ in use. • ValPro System Qualification package for full validation to meet all regulatory requirements DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 2

ANSWERS YOU CAN TRUST THE RAMAN MICROSCOPE DESIGNED WITH YOU IN MIND

Results Made Easy From the Experts in Raman Microscopy

The DXR Raman microscope lets the user focus on the results, not on learning new techniques With many years of experience in Raman and Unlock the power of Raman microscopy, effortlessly… FT-IR microscopy, Thermo Fisher Scientific Your Applications and Raman Microscopy and procedures. At Thermo Scientific, we design instruments that take care of the details. has designed the DXR Raman microscope You are going to find yourself relying on your Raman microscopy is of critical value in industrial and to encompass all the benefits of Raman DXR Raman microscope for many of your most non-industrial environments alike. New applications microscopy in one simple, easy-to-use challenging applications. For small particle analysis, are being discovered daily in: Top Quality Results Made Easy – instrument. The DXR Raman microscope the 1-micron spatial resolution is invaluable. In • Dyes and Chemicals • Fibers unique software features optimize signal-to-noise includes patented technology to take Patent addition, the DXR Raman microscope gives you • Pharmaceuticals • Nanotechnology to reveal even the finest details in a spectrum of Pending the guesswork out of achieving optimal true confocal depth profiling abilities, enabling • Packaging • Polymers Tyrian Purple pigment. performance – routinely and reproducibly. you to look for evidence of inclusions or impurities • Paper Manufacturing • Forensics This is the Raman microscope that the busy and characterize multi-layer polymer films. • Gemstones • Geology analytical lab cannot afford to be without. • Art Restoration and the Study of Cultural Artifacts Raman provides many benefits: Raman microscopy is employed at many stages in the Autofocus – • Rapid and non destructive manufacturing process from research to final product QC: optimizes the focus to • No sample preparation • Methods Development • R & D maximize the Raman • No water interference – easy to measure aqueous samples • QA/QC • Reverse Engineering signal automatically. • Complementary to FT-IR • Failure and Defect Analysis • Easy access to low vibrational frequencies, Smart making it easy to analyze inorganic molecules Background – Automatic Fluorescence Correction – the DXR Raman automatically corrects for fluorescence interference. microscope collects Available for all excitation lasers. background data The DXR Raman Microscope during instrument The DXR Raman microscope is a research-quality tool designed specifically for today’s multi-purpose downtime, so that analytical labs. This is the microscope for the user who needs the high spatial resolution, ease of the user never sample preparation and power of Raman microscopy, and who has neither the time nor the desire • Patented autoalignment has to wait. to become a Raman expert. The DXR Raman microscope delivers spatial system for guaranteed optimal performance resolution that is as good or better than any instrument on the market, • True point-and-shoot Raman together with unique features designed to make it as easy as Autoexposure – the DXR Raman capability possible to get high quality results. microscope calculates the exposure time and • Exceptional spatial resolution number of exposures for optimal sensitivity. • Superb visual quality

Laser Power Regulator – compensates for Automatic Intensity Correction – changes in laser power output and guarantees consistent compensates for detector wavelength dependence. Raman response. Legend: Zone A: The Laser Power Regulator controls the laser power reaching the sample to ensure reproducible results. Zone B: As the laser power declines over its lifetime, measurements become non-reproducible on instruments lacking a Laser Power Regulator. Zone C: Beyond the expected laser lifetime. The DXR Raman microscope can still be used reproducibly at lower power levels, however the laser should be replaced in order to obtain maximum power output. The Answers You Need

Whether it’s library searches to identify unknowns, data interpretation for large collections of samples, or mapping the distribution of key components, the DXR Raman microscope and the OMNIC software suite make it easy to focus on the answers. Identify Unknowns

Sophisticated Spectral Analysis – InterpretIR+™ identifies key spectral features in a nylon fiber sample.

The most extensive Raman libraries

Sophisticated Mapping and Data Analysis

OMNIC Atlµs mapping software combines hyperspectral mapping with image analysis Overlay of chemical and video map to show algorithms and chemometric tools. Analyze distribution of components sample cross-sections, extract sample component information using MCR then map and quantify the distribution of components. Add mapping capability to the DXR Raman microscope for ever more sophisticated applications.

Distribution of the two major tablet components generated by MCR analysis Atlµs generates an information-rich map of a painkiller tablet of the hyperspectral Atlµs map Laboratory Solutions Backed by Worldwide Service and Support In addition to these offices, Thermo Fisher Scientific maintains a network With its user-friendly patented autoalignment and calibration, plus its user-replaceable of representative organizations lasers, gratings and filters, the DXR Raman microscope has been designed to need throughout the world. little service attention. However, we know that in today’s busy, multifunctional

laboratories you cannot afford to be without your workhorse instruments for even Africa the shortest time. With the most extensive world-wide organization of field service +43 1 333 5034 127 • [email protected] Australia engineers, you can count on us to keep you up and running. +61 2 8844 9500 • [email protected] Austria First class service and support allow you to get the most out of your microscope +43 1 333 50340 • [email protected] and samples. With our expertise in applications support, we offer comprehensive Belgium +32 2 482 30 30 • [email protected] training to take you to the next level. Canada +1 800 530 8447 • [email protected] China +86 10 5850 3588 • [email protected] The Thermo Scientific Family of Raman Spectrometers Denmark +45 70 23 62 60 • [email protected] Nicolet Almega XR Europe-Other The Thermo Scientific Nicolet™ Almega™ XR is a high- +43 1 333 5034 127 • [email protected] performance dispersive Raman spectrometer. Fully France automated and with micro and macro sampling combined +33 1 60 92 48 00 • [email protected] in one instrument, the Almega XR offers the ultimate in Germany performance, automation and flexibility. The Almega XR +49 6103 408 1014 • [email protected] is ready for any sample and meets the needs of even the India • most demanding applications. +91 22 6742 9434 [email protected] Italy +39 02 950 591 • [email protected] Japan +81 45 453 9100 • [email protected] Latin America +1 608 276 5659 • [email protected] NXR FT-Raman Series Middle East The Nicolet NXR FT-Raman spectrometer uses 1064- +43 1 333 5034 127 • [email protected] or 976-nm excitation lasers for radical reduction in Netherlands • fluorescence interference. With the most extensive +31 76 587 98 88 [email protected] sampling accessories available, including the FT-Raman South Africa +27 11 570 1840 • [email protected] MicroStage for microscopic analysis, the NXR FT-Raman spectrometer can be configured either as a dedicated, Spain +34 914 845 965 • [email protected] stand-alone system or as an accessory for FT-IR spectrometers. Sweden / Norway / Finland +46 8 556 468 00 • [email protected] Switzerland +41 61 48784 00 • [email protected] DXR SmartRaman UK Built on the same platform as the DXR Raman microscope, +44 1442 233555 • [email protected] the DXR SmartRaman spectrometer is dedicated to bulk USA sample analysis. It is intended for use in busy multi-purpose +1 800 532 4752 • [email protected] analytical labs, where the users are looking for reproducible and accurate results from a dependable, low maintenance www.thermo.com instrument.

Thermo Electron Scientific Instruments LLC, Madison, WI USA is ISO Certified. The DXR Raman microscope is a Class IIIb laser-safe product, unless installed with the Class I Laser Safety Enclosure. Installation of a fiber optic probe launcher and fiber probe will convert all microscopes to Class IIIb laser-safe, even with the Laser Safety Enclosure installed. ©2008 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries. Specifications, terms and pricing are subject to change. Not all products are available in all countries. Please consult your local sales representative for details.

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