Methoxy-6-Methylflavone and Kavain at Recombinant GABAA Receptors
Pharmacology profile of 2′-methoxy-6-methylflavone and kavain at recombinant GABAA receptors Han Chow Chua BPharm (Hons) A thesis submitted in fulfilment of the requirements for the award of Doctor of Philosophy Faculty of Pharmacy The University of Sydney 2016 Acknowledgements Firstly, I would like to express my sincere gratitude to my supervisor Professor Mary Collins for her continuous support, guidance, patience and motivation throughout my PhD. Besides my supervisor, I would like to thank Professor Jane Hanrahan, Dr Nathan Absalom and Dr Petra van Nieuwenhuijzen for their insightful comments and encouragement, which were precious for the writing of this thesis. My sincere appreciation also goes to Associate Professor Philip Ahring for providing me with valuable guidance in molecular biology and electrophysiology; Associate Professor Thomas Balle for his immense knowledge in molecular modelling; Dr Raja Viswas for the synthesis of various chemicals used in this study. I would also like to thank my colleagues and lab buddies (in no particular order): Vivian, Irene, Radhika, Zirong, Taima, Leonny, Jia, Bryan, Ting, Steve, Terry, Tim, Izumi, Ida and Maja for their friendship, support, shared knowledge and experiences over the years, which helped me stay sane through those hair-pulling moments. Last but not least, my heartfelt gratitude goes to my family, as none of this would have been possible without their support. They have been a constant source of love, concern, support and strength throughout all these years and I deeply appreciate their faith in me. Abstract GABAA receptors (GABAARs) are a class of physiologically- and therapeutically- important ligand-gated ion channels.
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