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Masterpass : Pharmacology in 7 Days for Medical Students Pharmacology in 7 Days for Medical Students FAZAL-I-AKBAR DANISH CT2 in Medicine Princess of Wales Hospital in Bridgend and AHMED EHSAN RABBANI Final Year Medical Student Foundation University Medical College (FUMC) Rawalpindi, Pakistan Radcliffe Publishing Oxford • New York CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2010 by Fazal-I-Akbar Danish CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Version Date: 20160525 International Standard Book Number-13: 978-1-138-03114-2 (eBook - PDF) This book contains information obtained from authentic and highly regarded sources. While all reasonable efforts have been made to publish reliable data and information, neither the author[s] nor the publisher can accept any legal responsibility or liability for any errors or omissions that may be made. The publishers wish to make clear that any views or opinions expressed in this book by individual editors, authors or contributors are personal to them and do not necessarily reflect the views/ opinions of the publishers. The information or guidance contained in this book is intended for use by medical, scientific or health-care professionals and is provided strictly as a supplement to the medical or other professional’s own judgement, their knowledge of the patient’s medical history, relevant manufacturer’s instructions and the appropriate best practice guidelines. Because of the rapid advances in medical science, any information or advice on dosages, procedures or diagnoses should be independently verified. The reader is strongly urged to consult the relevant national drug formulary and the drug companies’ and device or material manufacturers’ printed instructions, and their websites, before administering or utilizing any of the drugs, devices or materials mentioned in this book. This book does not indicate whether a particular treatment is appropriate or suitable for a particular individual. Ultimately it is the sole responsibility of the medical professional to make his or her own professional judgements, so as to advise and treat patients appropriately. The authors and publishers have also attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, micro- filming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http://www. copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750- 8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identifi- cation and explanation without intent to infringe. Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com Contents Preface iv About the authors v Contributors vi 1 General pharmacology 1 2 Classifi cations 11 3 Mechanisms of action 51 4 Therapeutic uses and side effects 96 5 Drug differences 131 6 Miscellaneous 141 7 Important tables 146 Index 153 Preface Pharmacology is a volatile subject with a ‘very short half-life’. One can cram 20 side effects of a single drug but when one is required to memorise the side effects of 150 drugs, everything gets jumbled up. The same holds true for the lists of therapeutic uses and drug classifi cations that pharmacology students have to memorise and reproduce in the exam setting. No wonder that many medical students fail in pharmacology not because they haven’t ‘studied’ the subject but simply because they haven’t ‘retained’ the subject matter. This book is written to help solve a very specifi c and practical problem: how to reproduce the pharmacology subject matter in the exam setting. First, instead of dividing the syllabus in the conventional way, i.e. ‘systems’, it is being divided into classifi cations, mechanisms of action, therapeutic uses, side effects, etc. In the current exam format, it is very unlikely that someone would ask to write an ‘essay’ on a given drug; instead, very specifi c questions are asked, like ‘give the thera- peutic uses of drug “A”’, or ‘enumerate the side effects of drug “B”’, etc. Examiners are more interested in asking, for example, the side effects of chloramphenicol so that students know why this drug is not used commonly any more, as compared to the mechanism of action of this drug. Thus, in the chapter on side effects, the side effects of most commonly asked drugs are given; in the chapter on mechanisms of action, the mechanisms of action of most commonly asked drugs are given. The book may appear defi cient in the classical sense – it may contain the side effects of a given drug, with no mention of its mechanism of action or therapeutic uses. But the very aim of writing this book was not to write another treatise of every- thing about every drug, but to ‘distil’ the information that is directly and specifi cally relevant to the exams. The book thus truly deserves its title, Pharmacology in 7 Days for Medical Students. Students can forget everything they have ever studied about pharmacology in the last seven days prior to the exams, cram this 166-page book and (still) hold a bright chance of passing every and any pharmacology exam. Fazal-I-Akbar Danish Ahmed Ehsan Rabbani January 2010 iv About the authors Dr Fazal graduated from Army Medical College, Rawalpindi, Pakistan in 1999. After working in his home country for a few years in various capacities, he came to the UK in 2005. Here he has worked as Clinical Research Fellow in the Universities of Southampton and Bristol, and as a Medical SHO in various NHS trusts. Although a junior doctor, Dr Fazal has contributed appreciably in medical literature. He is the fi rst and corresponding author of eight research papers published in different peer- reviewed journals. He has contributed a 28-web-page section namely ‘Phenotyping’ in an online encyclopaedia entitled ‘Online Encyclopaedia of Genetic Epidemiology Studies’, www.oege.org. This section links and describes standardised research protocols and related information for clinical phenotyping on common diseases and risk traits. It is primarily of relevance and consumption of researchers and PhD students. Dr Fazal has three medical books to his credit – the book in your hand, Hospital Dermatology (a 226-page book for fi nal-year medical students and postgraduate trainees) and Essential Lists of Differential Diagnoses for MRCP: with diagnostic hints (a 272-page book for postgraduate doctors preparing for MRCP (UK) and FCPS (Pakistan) examinations). He is currently working as a CT2 in Medicine at the Princess of Wales Hospital in Bridgend. Ahmed Ehsan Rabbani is a fi nal-year medical student and the younger brother of Dr Fazal. It was Ahmed who highlighted the need for a pharmacology book that medical students could refer to during the last few days before the exam. To realise his vision, he contributed substantially in the design, literature search, drafting, picture draw- ing and revision of the manuscript. His most valued contribution is giving his elder brother the all-critical insight regarding what to include and what to exclude in this revision book. v Contributors Salman S Koul MBBS FCPS-I (Pak) MCPS (Pak) Registrar Department of Medicine Pakistan Institute of Medical Sciences (PIMS) Islamabad, Pakistan Fazal R Subhani MBBS FCPS-I (Pak) Registrar Department of Pediatrics Holy Family Hospital Rawalpindi, Pakistan Saeeda Yasmin MBBS FCPS (Pak) MRCS (UK) Consultant Surgeon Shifa Hospital Islamabad, Pakistan vi 1 General pharmacology Pharmacology 1 Brief defi nition: Science that deals with drugs. 2 Broad defi nition: Science that deals with the interaction between living systems and molecules, especially the chemicals introduced from outside the system. 3 Comprehensive defi nition: Knowledge of history, source, physical and chemical properties; compounding absorption, bio-transformation, distribution, excretion, mechanism of action, structural activity relationship, bio-chemical and physiologi- cal effects, and therapeutic/other uses of drugs. WHO defi nition of drug A drug is any substance or product that is used or intended to be used to modify or explore physiological symptoms or pathological states for the benefi t of the recipient. Defi nition of rational drug therapy Administration of the right drug indicated for the disease, in the right dose, through an appropriate route of administration, for the right duration. Criteria for right drug • Cost-effectiveness • Effi cacy • Safety Alkaloids Characteristics Mostly solid (rarely liquid), nitrogenous compounds, complex structure, found in plants, intensely bitter in taste, very active biologically, basic in nature and form water-soluble salts with acids, e.g. ephedrine, otherwise insoluble in water (soluble in alcohol). Their names end in the suffi x ‘ine’. Examples Solid alkaloids: Morphine, codeine, ephedrine, atropine, hyoscine, quinine, ergotamine, strychnine. Liquid alkaloids: Nicotine, lobeline, pilocarpine. PHARMACOLOGY IN 7 DAYS FOR MEDICAL STUDENTS Glycosides Characteristics These are an ether-like combination of sugars with organic structure. They are complex-structured, non-nitrogenous compounds found in plants containing C, H and O2, very active biologically, hydrolysed by acids/enzymes into: A Sugar portions or glycone.
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