ELEMENTAL COMPOSITION of HUMAN and ANIMAL MILK a Review by G.V
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IAEA-TECDOC-269 ELEMENTAL COMPOSITION OF HUMAN AND ANIMAL MILK A Review by G.V. IYENGAR A REPORT PREPARED UNDER THE AUSPICES OF THE INTERNATIONAL ATOMIC ENERGY AGENCY IN COLLABORATION WITE HTH WORLD HEALTH ORGANIZATION A TECHNICAL DOCUMENT ISSUED BY THE INTERNATIONAL ATOMIC ENERGY AGENCY, VIENNA, 1982 ELEMENTAL COMPOSITION OF HUMAN AND ANIMAL MILK: A REVIEW IAEA, VIENNA, 1982 IAEA-TECDOC-269 PrinteIAEe th AustriAn y i d b a September 1982 IAEe Th A doe t maintaisno n stock f reportso thin si s series. However, microfiche copies of these reports can be obtained from INIS Clearinghouse International Atomic Energy Agency Wagramerstrasse 5 P.O. Box 100 A-1400 Vienna, Austria Orders should be accompanied by prepayment of Austrian Schillings 80.00 in the form of a cheque or in the form of IAEA microfiche service coupons orderee whicb y dhma separately fro INIe mth S Clearinghouse. PLEASE BE AWARE THAT ALL OF THE MISSING PAGES IN THIS DOCUMENT WERE ORIGINALLY BLANK FOREWORD For the past three years, the International Atomic Energy Worle Agencth dd Healtan y h Organization have been collaboratinn o g a joint research project to obtain definitive baseline data on the concentrations of twenty-four mineral and trace elements in human milk, specimens collected from nursing mothers in six Member States. Over the same period, the IAEA has also organized and provided suppor a coordinate o t d research programme, wit 3 participant1 h n i s 1 Membe1 r States n comparativo , e e studmethod th f traco yr fo se elements in human nutrition; this programme has also been concerned, inter alia, with the analysis of human milk. In both these programmes, nuclear analytical techniques, particularly neutron activation analysis, have playe n importana d t role a fac, t which explain n pare i IAEA'sth t s interes n supportini t g this kinf o d research. In the joint IAEA/WHO research project, for example, 16 of the 24 elements under investigation (As, Cd, Cl, Co, Cu, Fe, Hg, ) havZn ed beean V n , analyseSn , Se y neutro b d, Sb , nP , Mo , IMn , activation analysif advanceo d sai d wite th research h nuclear reactors. The important advantages of this technique in such application s higit h e analyticaar s l sensitivity, relativelw lo y susceptibility to matrix effects and analytical blanks, and the possibilit determininf yo g several elements concurrently. » As background material for both the above-mentioned programmes, e respectivth s fely b wa t t i e participants that a grea thers wa te need for a comprehensive modern review of the published literature e th elementaon l compositio f o human n milk, together with comparative data on animal milks. The present report, containing data provided by a variety of analytical techniques, both nuclear and non-nuclear, was commissioned by the IAEA to help fulfill this need, and the Agency acknowledges with gratitude the contributions of the author, Dr. lyengar, in compiling and evaluating the data presented here. This technical report was edited and prepared for publication by Dr. R.M. Parr and Ms. S.A. Clements, of the IAEA's Medical Applications Section, Department of Research and Isotopes. PREFACE Breast-milk is the best source of food for the young infant; it s i usually sufficien o covet tl nutrienal r t requiremente th o t p u s x monthssi f agfou o eo t r. Thereafter t i remain, n excellena s t sourc f proteio e d othean n r nutrient t e supplementeneedb bu s o t s d by other foods. Wite progresth h f o industrializations , breast- feeding has been declining in all developed countries. This, however, has had few harmfull consequences because breast-milk substitutes have been developed by industry which are highly nutritious and safe when properly used. While no, or very little, e chils th resulteha har do t m d under these circumstancese th , situation is quite different in developing countries where the decline of breast-feeding, especially in urban and peri-urban areas, may have dire consequence e healtth d nutritionar an hfo s l statuf o s the young child and may result in an increased morbidity and mortality. On the other hand, new information has become available which indicates that breast-mil t onl no a ysourc s i k f nutriento e s but contributes.also to the defence mechanisms of the child against infectious alsdiseasesy oma contait I . n some other constituents, the significanc f whico e s i stilh l poorly understood. This explains the renewed interest in breast-feeding, not only among health personnel but also in other circles which have become alarmed by its decline. The importanc t o trace e element n i nutritiowidelsw no y s i n recognize e lis f th elemento td an d s thae indispensablar t o goot e d nutrition is increasing steadily- Greater attention is therefore bein e gtrac th pai eo t d element conten f foodse o td th stud an f ,o y compositio f breast-milo n n thii k s respec s i essentiat n viei lf wo s uniquit e contributio e feedinth o f t ninfantso g Worle Th d. Health Organization has initiated a number of studies on the composition of breast-mil e Internationath d an k l Atomic Energy Agenc s collabha y - orated on some of them. The present publication constitutes a particularly useful contribution to this joint endeavour and will no doubt provide useful informatio n somo n e aspecte compositioth f o s n of breast-mil r beefa kno s whicdifficult s t impossibleha hno f i , , to obtain anywhere else, The Agency and Dr. G.V. lyengar should be congratulated for this endeavour. E.M. DeMaeyer WHO, Geneva ABSTRACT A revie s presentei we elementath f o d l compositio f humao nd an n animal milk with special reference to trace elements. Literature data e discussear d tabulate an 0 d5 separat n i d e tables (on r eacefo h element )perioe mainlth r d fo yafte r 1950. Each table use a sstandar d format comprising 10 columns indicating (1) source of milk. (e.g. human or animal), (2) status of the milk (colostrum, transitional or mature), (3) country of origin, (4) year of data publication, (5) mean concent- ration, (6) range of single values or standard deviation of the mean, ) numbe(7 f samplero s analysed ) analytica(8 , l technique employed) (9 , literature datae sourcd th (10 an ,f o e) relevant remarks f anyi , e .Th most abundant data refer to the minor elements Ca, Cl, K, Mg, N, Na, P . e tracFeweZn th d eo r t an element date d e availF ar an aan , S dCu - s able for Cd, Hg, I, Mn, Pb and Se. For the remaining elements', including such biologically importan, F t , tracCr , e Co element , As s a s Mo, Ni, Si and Sn, very few reliable data so far appear to exist. EDITORIAL NOTE Ia publlcacion f chino ss almos I kin t I dt inevitable that some errors may have been made either in extracting the data from the original references or in preparing them for publication. If any such errors shoul e dattentio th come reader o th t e f t woulo ni , e b d appreciated if he or she would report them both to the editors and to the author, Dr. lyengar*. The views and conclusions expressed in this report are not necessarily those of the International Atomic Energy Agency or the World Health Organization. * Address for correspondence Dr. G.V. lyengar Institut fur Medizin KFA Jiilich P.O191x Bo 3. D-5170 Julich 1 Federal Republi f o Germanc y CONTENTS. 1. INTRODUCTION .....................................1 . 2. SOME BASIC PROPERTIES OF MILK .................... 2 3. TYPES OF MILK .................................... 2 4. COMPONENTS OF MILK ............................... 3 5. FACTORS INFLUENCING THE COMPOSITION OF MILK ...... 6 6. ANALYTICAL CONSIDERATIONS .......................6 . 7. SOURCE INFORMATIOF SO MILN NO K ..................1 1 . 8. ELEMENTAL COMPOSITIO MILF NO K ...................8 1 . 3.1. General Remarks ........................... 13 8.2. Tabulatio Literaturf no e Dat Specifir fo a c Elements .................................9 1 . Aluminium (Tabl .....................) 5 e 0 2 . Antimony (Tabl .....................) 6 e 4 2 . Arsenic (Table?) .....................5 2 . Barium (Table 8) ...................... 26 Beryllium (Tabl .....................) 9 e 8 2 . Bismuth (Tabl ....................) 10 e 8 2 . Boron (Table 11) ..................... 29 Bromine (Table 12) ...................... 30 Cadmium (Tabl ....................) 13 e 2 3 . Caesium (Table 14) ..................... 34 Calcium (Table 15) ..................... 36 Cerium (Table 16) ..................... 42 Chlorine (Tabl ....................) 17 e 4 4 . Chromium (Table 18) ..................... 48 Cobalt (Table 19) ..................... 50 Copper (Table 20) ..................... 52 Europium (Tabl ) ....................21 e 9 5 . Fluorine (Table 22) ..................... 60 Germanium (Tabl ....................) 23 e 2 6 . Iodine (Table 24) ..................... 63 Iron (Tabl ....................) 25 e 7 6 . Lanthanum (Table 26) ..................... 75 Lea • d (Tabl ) ....................27 e 6 7 . Lithium (Tabl ....................) 28 e 0 8 . Magnesium (Tabl ..........'..........) 29 e 1 8 . Manganese (Tabl ....................) 30 e 6 .8 Mercury - (Table 31) ..................... 91 Molybdenum (Table 32) ..................... 94 Nickel (Table 33) ..................... 96 Niobium (Table 34) ..................... 98 Nitrogen (Table 35) ..................... 100 Phosphorus (Tabl ....................) e36 2 .10 Potassium (Table 37) ... o................. 107 Rubidium (Tabl .....) 38 e . c.............4 .11 Scandium (Table 39) ..................... 115 Selenium (Table 40) ..................... 116 Silicon (Tabl ....................) 41 e 0 .12 Silver (Table 42) ..................... 121 Sodium (Tabl ....................) e43 2 .12 Strontium (Tabl ....................) e44 8 .12 Sulphur (Table 45) ..................... 130 Tellurium (Tabl ....................) 46 e 2 .13 Thorium (Table 47) ..................... 132 Tin (Table 48) ..................... 133 Titanium (Table 49) ..................... 134 Uranium (Tabl ....................) 50 e 6 .13 Vanadium (Table 51) ....................