Newsletter May 2021 Optimal Personalised Treatment of early breast cancer using Multi-parameter Analysis

Recruitment update: In April, 46 new participants were recruited into OPTIMA. Total recruitment to date: 2569 OPTIMA Main - 2157 participants OPTIMA prelim - 412 participants

Top 10 recruiters for 2021 Keep an eye out for the next Participants Site Name: recruited: ‘Lunch with OPTIMA’ The Christie 10 Oslo University Hospital (Norway) 10 Date TBC

Royal Alexandra Hospital, Paisley 9 Ostfold Hospital, Kalnes (Norway) 8 The meeting will focus on the recent changes made Velindre Cancer Centre 7 to the Tissue Transit form and will provide Site staff Royal Devon and Exeter Hospital 6 an opportunity to ask any questions about how to Royal Albert Edward Infirmary, Wigan 6 complete this form. Sorlandet Hospital, Kristiansand (Norway) 6 Further information and Teams meeting link will be New Victoria Hospital, 6 sent via email in due course. Charing Cross, London 6

As of 26 May, over 200 patients have consented What should I be sending to the lab…? to take part in OPTIMA this year so far, from a total of 68 hospitals throughout the UK, Norway and Sweden. Along with the tumour sample, HSL-AD only require copies of the Tissue Transit Forms and anonymised Pathology Reports. This is a massive achievement and we want to thank all of our hard working teams. Keep up the great work! Please do not send any CRFs to HSL-AD. These should be sent to WCTU only.

Tumour blocks and required paperwork should be posted to Qualitative Recruitment the lab at the below address: Study Patient Interviews HSL-Advanced Diagnostics Thank you for identifying patients Ground Floor for interview as part of the QRS. 60 Whitfield Street We’ve now reached a point where we’re happy with our London initial findings and so we’ve decided to pause patient W1T 4EU interviews for now. Please also remember that no patient identifiable information We hope to share our findings at a ‘Lunch with OPTIMA’ should be sent to the WCTU or to HSL-AD. WCTU and HSL-AD session in the early summer. In the meantime, if you do not need copies of patient consent forms. have any questions about the interviews, please feel free to contact us directly: [email protected], Welcome to the OPTIMA Team! [email protected] Amy Broadfield joined the WCTU OPTIMA team as our Thank you again for your contribution to this work, new Trial Coordinator on 24th May 2021. Nicola and Carmel. Welcome to the team!

Contact Us OPTIMA office 02476 151948 [email protected] QRS 01179 287296 [email protected] Recruitment per recruiting Site (up to 21 May 2021)

University Hospitals of North Midlands NHS Trust 68 York Hospital 16 Addenbrooke's Hospital 62 Darent Valley Hospital, Dartford 15 Mount Vernon Cancer Centre 62 Norfolk & Norwich University Hospital 15 Bristol Haematology & Oncology Centre 58 Royal Glamorgan Hospital 15 Velindre Cancer Centre 57 Royal Gwent Hospital 15 The Christie 56 Stepping Hill Hospital 15 Blackpool Victoria Hospital 55 Basingstoke and North Hampshire Hospital 14 Beatson West of Cancer Centre 52 Queens Hospital, Burton upon Trent 14 Oslo University Hospital (Norway) 52 Royal Cornwall Hospital 14 University Hospital Coventry 51 Bradford Royal Infirmary 13 NHS Lanarkshire 49 George Eliot Hospital, Nuneaton 13 Royal Albert Edward Infirmary, Wigan 47 St Mary's Hospital, Isle of Wight 12 Inverclyde and Royal Alexandra Hospitals 42 University College London Hospital 12 Peterborough City Hospital 40 Western General Hospital, Edinburgh 12 Weston Park Hospital, Sheffield 35 Chase Farm Hospital, Enfield (RFL) 11 Wrexham Maelor Hospital, Wrexham 35 St George's Hospital, London 11 Royal Devon and Exeter Hospital 33 Guys Hospital 10 University Hospitals of Morecambe Bay 32 NHS Ayrshire and Aran 10 East Kent Hospitals NHS Foundation Trust 31 Royal Hampshire County Hospital, Winchester 10 Glan Clwyd Hospital, Bodelwyddan 31 University Hospital of North Tees, Stockton-on-Tees 10 Luton and Dunstable University Hospital 31 Worcestershire Royal Hospital 10 Ostfold Hospital, Kalnes (Norway) 31 Northumbria Healthcare NHS Foundation Trust 9 Torbay Hospital 31 Airedale General Hospital, Keighley 8 Royal Shrewsbury Hospital 30 Bedford Hospital 8 Salisbury District Hospital 30 Charing Cross, London 8 Surrey and Sussex Healthcare NHS Trust 30 King's Mill Hospital 7 The Princess Alexandra Hospital NHS Trust 30 Prince Charles Hospital, Merthyr Tydfil 7 Derriford Hospital, Plymouth 29 Sunderland Royal Hospital 7 Forth Valley Hospital 29 Weston General Hospital, Weston Super Mare 7 Macclesfield District Hospital 28 Whittington Hospital, London 7 Maidstone Hospital 28 Hinchingbrooke Hospital, Huntingdon 6 Musgrove Park Hospital, Taunton 25 Sahlgrenska University Hospital (Sweden) 6 Russells Hall Hospital, Dudley 25 Basildon University Hospital 5 Churchill Hospital, Oxford 24 Dumfries and Galloway Royal Infirmary 5 Queen Elizabeth Hospital, Birmingham 23 Northern Lincolnshire and Goole 5 Queen Elizabeth Hospital, Gateshead 23 East Sussex Healthcare NHS Trust 4 Clatterbridge Cancer Centre 22 Nottingham University Hospital 4 Milton Keynes University Hospital 22 Pennine Acute Hospitals, North Manchester 4 New Cross Hospital, Wolverhampton 22 Royal Derby Hospital 4 North Middlesex Hospital 21 Stavanger Hospital (Norway) 4 Barnet Hospital (RFL) 20 University Hospital of North Norway 4 Frimley Park Hospital, Surrey 20 Worthing Hospital 4 Southampton General Hospital 20 Chesterfield Royal Hospital 3 Darlington Memorial Hospital 19 Haukeland University Hospital (Norway) 3 Medway Maritime Hospital, Gillingham 19 Kidderminster Hospital 3 Royal United Hospital, Bath 19 Queen's Hospital, Romford 3 Belfast City Hospital 18 Singleton Hospital, Swansea 3 Sorlandet Hospital, Kristiansand (Norway) 18 Ulster Hospital 3 Great Western Hospital, Swindon 17 Ysbyty Gwynedd, Bangor 3 Leighton Hospital 17 Birmingham City Hospital 2 Lister Hospital 17 Broomfield Hospital 2 New Victoria Hospital, Glasgow 17 Doncaster Royal infirmary 2 Queen Elizabeth Hospital, King's Lynn 16 Alexandra Hospital, Redditch 1 Royal Free Hospital 16 Wycombe Hospital ` 1