DOCSLIB.ORG

C:\Documents and Settings\Administrator\桌面\List Of

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
C:\Documents and Settings\Administrator\桌面\List Of Compoun Mol_For Mol_Wei Exact CAS STRUCTURE d_Name mula ght Mass Kushenol 99217-63- C25H28O 408.49 408.19 A 7 5 Kushenol 99119-69- C26H30O 454.51 454.20 I 4 7 Kushenol 102490- C26H30O 454.51 454.20 N 65-3 7 Kurarinon 34981-26- C26H30O 438.51 438.20 e 5 6 Isokurarin 97938-31- C26H30O 438.51 438.20 one 3 6 2’- 270249- C27H32O Methoxyk 452.54 452.22 38-2 6 urarinone Sophorafl 97938-30- C25H28O avanone 424.49 424.19 2 6 G 34981-25- C26H30O Kuraridine 438.51 438.20 4 6 dl- 19908-48- C16H12O 284.26 284.07 Maackiain 6 5 C32H22O Ginkgetin 481-46-9 566.51 566.12 10 C31H20O Bilobetin 521-32-4 552.48 552.11 10 Isoginkget C32H22O 548-19-6 566.51 566.12 in 10 Sciadopity C33H24O 521-34-6 580.54 580.14 sin 10 Hinokiflav 19202-36- C30H18O 538.46 538.09 one 9 10 Eurycoma 84633-29- C20H24O 408.40 408.14 none 4 9 Pasakbu 138809- C20H24O 424.40 424.14 min B 10-6 10 Pasakbu 129587- C20H26O 410.42 410.16 min C 06-0 9 Eurylacto 149180- C19H22O 394.37 394.13 ne B 47-2 9 Longilacto 129587- C19H26O 366.41 366.17 ne 09-3 7 Canthin- C14H8N2 479-43-6 220.23 220.06 6-one O Canthin- 60755-87- C14H8N2 6-one N- 236.23 236.06 5 O2 oxide 9- Methoxyc 74991-91- C15H10N 250.25 250.07 anthin-6- 6 2O2 one 9- Methoxyc 137739- C15H10N anthin-6- 266.25 266.07 74-3 2O3 one N- oxide 1- Hydroxyc 80787-59- C14H8N2 236.23 236.06 anthin-6- 3 O2 one beta- Carboline- 89915-39- C14H12N 1- 240.26 240.09 9 2O2 propionic acid 7- Methoxy- beta- 137756- C15H14N carboline- 270.28 270.10 13-9 2O3 1- propionic acid C18H20N Novel / 296.36 296.15 2O2 Bayogeni C30H48O 6989-24-8 488.70 488.35 n 5 Macrocar 132951- C28H40O 472.61 472.28 pal A 90-7 6 Macrocar 142698- C28H40O 472.61 472.28 pal B 60-0 6 Macrocar 142647- C28H40O 472.61 472.28 pal D 71-0 6 145416- Macrocar 92- C28H38O 454.60 454.27 pal C/G 8/142628- 5 53-3 Macrocar 142628- C28H40O 472.61 472.28 pal E 54-4 6 Macrocar 172617- C28H38O 486.60 486.26 pal N 99-1 7 3- 102067- C16H14O Deoxysap 286.28 286.08 88-9 5 panone B C16H14O Brazilin 474-07-7 286.28 286.08 5 Sappanon 102067- C16H12O 284.26 284.07 e A 84-5 5 Sappanch 94344-54- C16H14O 286.28 286.08 alcone 4 5 Xanthohu C21H22O 6754-58-1 354.40 354.15 mol 5 Desmethy 115063- C20H20O lxanthohu 340.37 340.13 39-3 5 mol 8- 53846-50- C20H20O Prenylnari 340.37 340.13 7 5 ngenin 6- 68236-13- C20H20O Prenylnari 340.37 340.13 5 5 ngenin 6,8- 68236-11- C25H28O Diprenyln 408.49 408.19 3 5 aringenin 6- 97126-57- C25H28O Geranylna 408.49 408.19 3 5 ringenin Tanshino C19H18O 568-72-9 294.34 294.13 ne ĊA 3 27210-57- C19H22O Miltirone 282.38 282.16 7 2 1,2- 77769-21- C18H14O Dihydrota 278.30 278.09 2 3 nshinone I Methyl 18887-19- C20H18O tanshinon 338.35 338.12 9 5 ate Danshenx 98873-76- C21H20O 336.38 336.14 inkun D 8 4 Dihydrois 20958-18- C18H14O otanshino 278.30 278.09 3 3 ne I 1,2,5,6- Tetrahydr 126979- C18H16O 280.32 280.11 otanshino 84-8 3 ne ĉ Cryptotan 35825-57- C19H20O 296.36 296.14 shinone 1 3 Przewaqu 96839-29- C18H16O 296.32 296.10 inone C 1 4 Przewaqu 76843-23- C19H18O 310.34 310.12 inone A 7 4 beta,beta- dimethyla 24502-79- C21H22O 370.40 370.14 crylshikon 2 6 in Isobutylsh 52438-12- C20H22O 358.39 358.14 ikonin 7 6 Acetylshik 54984-93- C18H18O 330.33 330.11 onin 9 6 Deoxyshik 43043-74- C16H16O 272.30 272.10 onin 9 4 beta- Acetoxyis 69091-17- C23H26O 430.45 430.16 ovalerylal 4 8 kannin Amentofla C30H18O 1617-53-4 538.46 538.09 vone 10 Germacro 6902-91-6 C15H22O 218.33 218.17 ne Curcumen 100347- C15H22O 234.33 234.16 one 96-4 2 Curzeren 20493-56- C15H18O 230.30 230.13 one 5 2 Furanodie 24268-41- C15H18O 230.30 230.13 none 5 2 Isoferulic C10H10O 537-73-5 194.18 194.06 acid 4 Ginkgolid 15291-75- C20H24O 408.40 408.14 e A 5 9 Ginkgolid 15291-77- C20H24O 424.40 424.14 e B 7 10 Ginkgolid 15291-76- C20H24O 440.40 440.13 e C 6 11 Ginkgolid 107438- C20H24O 424.40 424.14 e J 79-9 10 33570-04- C15H18O Bilobalide 326.30 326.10 6 8 C15H10O Daidzein 486-66-8 254.24 254.06 4 C33H40O Icariin 489-32-7 676.66 676.24 15 Isoschafto 52012-29- C26H28O 564.49 564.15 side 0 14 Schaftosi 51938-32- C26H28O 564.49 564.15 de 0 14 35927-38- C26H28O Vicenin 1 564.49 564.15 9 14 23666-13- C27H30O Vicenin 2 594.52 594.16 9 15 59914-91- C26H28O Vicenin 3 564.49 564.15 9 14 Carnosic C20H28O 3650-09-7 332.43 332.20 acid 4 Rosmarini 20283-92- C18H16O 360.31 360.08 c acid 5 8 40456-50- C22H24O Yatein 400.42 400.15 6 7 Cyanidin C15H11Cl 528-58-5 322.70 322.02 chloride O6 Delphinidi C15H11Cl 528-53-0 338.70 338.02 n chloride O7 Peonidin C16H13Cl 134-01-0 336.72 336.04 chloride O6 Malvidin C17H15Cl 643-84-5 366.75 366.05 chloride O7 Petunidin C16H13Cl 1429-30-7 352.72 352.03 chloride O7 Delphinidi n-3-O- 28500-00- C21H21Cl 500.84 500.07 galactosid 7 O12 e chloride Delphinidi n-3-O- C21H21Cl 6906-38-3 500.84 500.07 glucoside O12 chloride Delphinidi n-3-O- 171370- C20H19Cl 470.81 470.06 arabinosid 55-1 O11 e chloride Cyanidin- 3-O- 27661-36- C21H21Cl 484.84 484.08 galactosid 5 O11 e chloride Cyanidin- 3-O- C21H21Cl 7084-24-4 484.84 484.08 glucoside O11 chloride Cyanidin- 3-O- 111613- C20H19Cl 454.81 454.07 arabinosid 04-8 O10 e chloride Petunidin- 3-O- 28500-02- C22H23Cl 514.86 514.09 galactosid 9 O12 e chloride Petunidin- 3-O- C22H23Cl 6988-81-4 514.86 514.09 glucoside O12 chloride Petunidin- 3-O- 679429- C21H21Cl 484.84 484.08 arabinosid 94-8 O11 e chloride Peonidin- 3-O- 28148-89- C22H23Cl 498.86 498.09 galactosid 2 O11 e chloride Peonidin- 3-O- C22H23Cl 6906-39-4 498.86 498.09 glucoside O11 chloride Peonidin- 3-O- 524943- C21H21Cl 468.84 468.08 arabinosid 91-7 O10 e chloride Malvidin- 3-O- 30113-37- C23H25Cl 528.89 528.10 galactosid 2 O12 e chloride Malvidin- 3-O- C23H25Cl 7228-78-6 528.89 528.10 glucoside O12 chloride Malvidin- 3-O- 679429- C22H23Cl 498.86 498.09 arabinosid 95-9 O11 e chloride Ganoderic 81907-62- C30H44O 516.67 516.31 acid A 2 7 Ganoderic 81907-61- C30H44O 516.67 516.31 acid B 1 7 Ganoderic 95311-97- C30H42O 514.65 514.29 acid C1 0 7 Ganoderic 103773- C30H46O 518.68 518.32 acid C2 62-2 7 Ganoderic 98665-14- C30H40O 512.63 512.28 acid F 6 7 Ganoderic 98665-19- C32H44O 572.69 572.30 acid H 1 9 Ganoderic 104700- C32H46O 574.70 574.31 acid K 95-0 9 Umbellifer 93-35-6 C9H6O3 162.14 162.03 one Bursehern 40456-51- C21H22O 370.40 370.14 in 7 6 Pluviatolid 28115-68- C20H20O 356.37 356.13 e 6 6 Syringare C22H26O 487-35-4 418.44 418.16 sinol 8 Matairesin C20H22O 580-72-3 358.39 358.14 ol 6 Chamaeja 89595-70- C33H28O 584.57 584.17 smenin C 0 10 Chamaeja 89595-71- C32H26O 570.54 570.15 smenin B 1 10 Isochama 865852- C32H26O ejasmenin 570.54 570.15 48-8 10 B Chamaeja 865852- C32H26O 570.54 570.15 smenin D 47-7 10 C21H24N Ajmalicine 483-04-5 352.43 352.18 2O3 Derwentio 1016987- C22H26O 466.44 466.15 side B 87-3 11 C19H18O Eucalyptin 3122-88-1 326.34 326.12 5 Pomolic 13849-91- C30H48O 472.70 472.36 acid 7 4 5,7,8- 60796-65- C12H12O Trimethox 236.22 236.07 8 5 ycoumarin Gomisin 82467-50- C22H26O 386.44 386.17 M1 3 6 Methyl 14050-92- C23H26N chanofruti 410.46 410.18 1 2O5 cosinate Isomogro 1126032- C60H102 1287.43 1286.65 side V 65-2 O29 Atractylon 6989-21-5 C15H20O 216.32 216.15 e Atractylen 73069-13- C15H18O 230.30 230.13 olide I 3 2 Atractylen 73069-14- C15H20O 232.32 232.15 olide II 4 2 Atractylen 73030-71- C15H20O 248.32 248.14 olide III 4 3 Atractylod 55290-63- C13H10O 182.22 182.07 in 6 C21H24O Trilobatin 4192-90-9 436.41 436.14 10 Deoxyact 264624- C37H56O 660.83 660.39 ein 38-6 10 87440-75- C15H14O Viteralone 242.27 242.09 3 3 Vitexilacto 61263-49- C22H34O 378.50 378.24 ne 8 5 C30H50O Betulin 473-98-3 442.72 442.38 2 Betulinic C30H48O 472-15-1 456.70 456.36 acid 3 C21H20O Afzelin 482-39-3 432.38 432.11 10 Asperulos 14259-45- C18H22O 414.36 414.12 ide 1 11 Calyciphyl 596799- C23H31N 385.50 385.23 line A 30-3 O4 Caraphen 354553- C42H28O 676.67 676.17 ol A 35-8 9 C15H20N Anagyrine 486-89-5 244.33 244.16 2O Mahanim 21104-28- C23H25N 331.45 331.19 bine 9 O 3- 25499-90- C30H48O Epioleano 456.70 456.36 5 3 lic acid Anwuligna 107534- C20H24O 328.40 328.17 n 93-0 4 Salidrosid 10338-51- C14H20O 300.30 300.12 e 9 7 Ruscogen C27H42O 472-11-7 430.62 430.31 in 4 Aristolochi C16H9NO 475-80-9 311.25 311.04 c acid B 6 C30H16O Hypericin 548-04-9 504.44 504.08 8 Phyltetrali 123048- C24H32O 416.51 416.22 n 17-9 6 Hypophyll 33676-00- C24H30O 430.49 430.20 anthin 5 7 50656-77- C24H32O Niranthin 432.51 432.21 4 7 Isolintetral 145459- C23H28O 400.46 400.19 in 30-9 6 Phyllanthi 10351-88- C24H34O 418.52 418.24 n 9 6 C14H16O Bergenin 477-90-7 328.27 328.08 9 Epigalloca techin C22H18O 989-51-5 458.37 458.08 gallate(E 11 GCG) Theaflavin C29H24O (Theaflavi 4670-05-7 564.49 564.13 12 n 1) Theaflavin -3,3'- 30462-35- C43H32O 868.70 868.15 digallate( 2 20 TF3) Theaflavin -3’- 28543-07- C36H28O 716.60 716.14 gallate(TF 9 16 2B) Theaflavin -3- 30462-34- C36H28O 716.60 716.14 gallate(TF 1 16 2A) C17H14O Ombuin 529-40-8 330.29 330.07 7 Neoschaft 61328-41- C26H28O 564.49 564.15 oside 4 14 C21H20O Vitexin 3681-93-4 432.38 432.11 10 29702-25- C21H20O Isovitexin 8/38953- 432.38 432.11 10 85-4 28608-75- C21H20O Orientin 448.38 448.10 5 11 C21H20O Isoorientin 4261-42-1 448.38 448.10 11 Vitexin - 178468- C27H30O 4''-O- 594.52 594.16 00-3 15 glucoside Vitexin - 2''-O- 64820-99- C27H30O 578.52 578.16 rhamnosi 1 14 de Micromeli 15085-71- C15H12O 288.25 288.06 n 9 6 Momordic 81910-39- C31H50O oside F1 470.73 470.38 6 3 aglycone 113558- C27H30O Icariside II 514.52 514.18 15-9 10 Kuguacin 1141453- C30H46O 454.68 454.34 J 65-7 3 Kuguacin 1141453- C30H46O 470.68 470.34 N 73-7 4 Kuguacin 191097- C30H48O 472.70 472.36 R 54-8 4 Momordici 91590-76- C30H48O 472.70 472.36 ne I 0 4 Sagittatos 118525- C33H40O 676.66 676.24 ide A 35-2 15 Sagittatos 118525- C32H38O 646.64
Load more

  1404
Copy Link
Recommended publications
  • Chromanone-A Prerogative Therapeutic Scaffold: an Overview
    Arabian Journal for Science and Engineering https://doi.org/10.1007/s13369-021-05858-3 REVIEW-CHEMISTRY Chromanone‑A Prerogative Therapeutic Scafold: An Overview Sonia Kamboj1,2 · Randhir Singh1 Received: 28 September 2020 / Accepted: 9 June 2021 © King Fahd University of Petroleum & Minerals 2021 Abstract Chromanone or Chroman-4-one is the most important and interesting heterobicyclic compound and acts as a building block in medicinal chemistry for isolation, designing and synthesis of novel lead compounds. Structurally, absence of a double bond in chromanone between C-2 and C-3 shows a minor diference from chromone but exhibits signifcant variations in biological activities. In the present review, various studies published on synthesis, pharmacological evaluation on chroman- 4-one analogues are addressed to signify the importance of chromanone as a versatile scafold exhibiting a wide range of pharmacological activities. But, due to poor yield in the case of chemical synthesis and expensive isolation procedure from natural compounds, more studies are required to provide the most efective and cost-efective methods to synthesize novel chromanone analogs to give leads to chemistry community. Considering the versatility of chromanone, this review is designed to impart comprehensive, critical and authoritative information about chromanone template in drug designing and development. Keywords Chroman-4-one · Chromone · Pharmacological activity · Synthesis · Analogues 1 Introduction dihydropyran (ring B) which relates to chromane, chromene, chromone and chromenone, but the absence of C2-C3 dou- Chroman-4-one is one of the most important heterobicyclic ble bond of chroman-4-one skeleton makes a minor difer- moieties existing in natural compounds as polyphenols and ence (Table 1) from chromone and associated with diverse as synthetic compounds like Taxifolin, also known as chro- biological activities [1].
    [Show full text]
  • Ep 3138585 A1
    (19) TZZ¥_¥_T (11) EP 3 138 585 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 08.03.2017 Bulletin 2017/10 A61L 27/20 (2006.01) A61L 27/54 (2006.01) A61L 27/52 (2006.01) (21) Application number: 16191450.2 (22) Date of filing: 13.01.2011 (84) Designated Contracting States: (72) Inventors: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB • Gousse, Cecile GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO 74230 Dingy Saint Clair (FR) PL PT RO RS SE SI SK SM TR • Lebreton, Pierre Designated Extension States: 74000 Annecy (FR) BA ME •Prost,Nicloas 69440 Mornant (FR) (30) Priority: 13.01.2010 US 687048 26.02.2010 US 714377 (74) Representative: Hoffmann Eitle 30.11.2010 US 956542 Patent- und Rechtsanwälte PartmbB Arabellastraße 30 (62) Document number(s) of the earlier application(s) in 81925 München (DE) accordance with Art. 76 EPC: 15178823.9 / 2 959 923 Remarks: 11709184.3 / 2 523 701 This application was filed on 29-09-2016 as a divisional application to the application mentioned (71) Applicant: Allergan Industrie, SAS under INID code 62. 74370 Pringy (FR) (54) STABLE HYDROGEL COMPOSITIONS INCLUDING ADDITIVES (57) The present specification generally relates to hydrogel compositions and methods of treating a soft tissue condition using such hydrogel compositions. EP 3 138 585 A1 Printed by Jouve, 75001 PARIS (FR) EP 3 138 585 A1 Description CROSS REFERENCE 5 [0001] This patent application is a continuation-in-part of U.S.
    [Show full text]
  • United States Patent (10 ) Patent No.: US 10,538,797 B2 Thomsen Et Al
    US010538797B2 United States Patent (10 ) Patent No.: US 10,538,797 B2 Thomsen et al. (45 ) Date of Patent : Jan. 21 , 2020 (54 ) METHOD FOR THE BIOTECHNOLOGICAL ( 56 ) References Cited PRODUCTION OF FLAVONE GLYCOSIDE DIHYDROCHALCONES U.S. PATENT DOCUMENTS 9,359,622 B2 * 6/2016 Hilmer C12Y 505/01006 (71 ) Applicant: SYMRISE AG , Holzminden (DE ) 2014/0045233 A1 * 2/2014 Hilmer C12Y 505/01006 435/148 ( 72 ) Inventors : Maren Thomsen , Greifswald (DE ) ; Jakob Ley , Holzminden ( DE ) ; Egon FOREIGN PATENT DOCUMENTS Gross , Holzminden (DE ); Winfried Hinrichs , Greifswald (DE ) ; Uwe EP 2 692 729 A1 2/2014 Bornscheuer, Greifswald (DE ) OTHER PUBLICATIONS ( 73 ) Assignee : SYMRISE AG , Holzminden (DE ) Accession V9P0A9 . Mar. 19 , 2014. Alignment to SEQ ID No. 2 ( Year: 2014 ). * ( * ) Notice : Subject to any disclaimer, the term of this Accession V9P0A9 . Mar. 19 , 2014. Alignment to SEQ ID No. 4 ( Year: 2014 ). * patent is extended or adjusted under 35 Accession KF154734 . Dec. 31, 2013. Alignment to SEQ ID No. 1 . U.S.C. 154 ( b ) by 16 days . ( Year: 2013 ) . * Accession KF154734 . Dec. 31, 2013. Alignment to SEQ ID No. 3 . ( 21 ) Appl. No.: 15 /322,768 ( Year : 2013 ) . * Chica et al. Curr Opin Biotechnol . Aug. 2005; 16 ( 4 ): 378-84 . ( Year : 2005 ) . * ( 22 ) PCT Filed : Jun . 27 , 2015 Singh et al . Curr Protein Pept Sci. 2017 , 18 , 1-11 ( Year: 2017) . * Bornscheuer et al. Curr Protoc Protein Sci. Nov. 2011; Chapter PCT No .: PCT/ EP2015 / 064626 26 :Unit26.7 . ( Year: 2011 ). * ( 86 ) Gall et al, “ Enzymatische Umsetzung von Flavonoiden mit einer $ 371 ( c ) ( 1 ) , backteriellen Chalconisomerase und einer Enoatreduktase ,” Angewandte ( 2 ) Date : Apr.
    [Show full text]
  • WO 2017/117099 Al 6 July 2017 (06.07.2017) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/117099 Al 6 July 2017 (06.07.2017) P O P C T (51) International Patent Classification: (US). GENESKY, Geoffery [FR/FR]; 14 Rue Royale, Λ 61Κ 8/04 (2006.01) A61K 8/97 (201 7.01) 75008 Paris (FR). A61K 8/06 (2006.01) A61K 31/70 (2006.01) (74) Agent: BALLS, R., James; Polsinelli PC, 1401 Eye A61K 8/34 (2006.01) A61K 31/351 (2006.01) Street, N.W., Suite 800, Washington, DC 20005 (US). A61K 8/60 (2006.01) A61K 31/355 (2006.01) A61K 5/67 (2006.01) A61K 31/7048 (2006.01) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, PCT/US20 16/068662 BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (22) International Filing Date: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 27 December 2016 (27. 12.2016) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (25) Filing Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (26) Publication Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (30) Priority Data: TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 62/272,326 29 December 201 5 (29.
    [Show full text]
  • Powerful Plant Antioxidants: a New Biosustainable Approach to the Production of Rosmarinic Acid
    antioxidants Review Powerful Plant Antioxidants: A New Biosustainable Approach to the Production of Rosmarinic Acid Abbas Khojasteh 1 , Mohammad Hossein Mirjalili 2, Miguel Angel Alcalde 1, Rosa M. Cusido 1, Regine Eibl 3 and Javier Palazon 1,* 1 Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Av. Joan XXIII sn, 08028 Barcelona, Spain; [email protected] (A.K.); [email protected] (M.A.A.); [email protected] (R.M.C.) 2 Department of Agriculture, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, 1983969411 Tehran, Iran; [email protected] 3 Campus Grüental, Institute of Biotechnology, Biotechnological Engineering and Cell Cultivation Techniques, Zurich University of Applied Sciences, CH-8820 Wädenswill, Switzerland; [email protected] * Correspondence: [email protected] Received: 19 November 2020; Accepted: 11 December 2020; Published: 14 December 2020 Abstract: Modern lifestyle factors, such as physical inactivity, obesity, smoking, and exposure to environmental pollution, induce excessive generation of free radicals and reactive oxygen species (ROS) in the body. These by-products of oxygen metabolism play a key role in the development of various human diseases such as cancer, diabetes, heart failure, brain damage, muscle problems, premature aging, eye injuries, and a weakened immune system. Synthetic and natural antioxidants, which act as free radical scavengers, are widely used in the food and beverage industries. The toxicity and carcinogenic effects of some synthetic antioxidants have generated interest in natural alternatives, especially plant-derived polyphenols (e.g., phenolic acids, flavonoids, stilbenes, tannins, coumarins, lignins, lignans, quinines, curcuminoids, chalcones, and essential oil terpenoids). This review focuses on the well-known phenolic antioxidant rosmarinic acid (RA), an ester of caffeic acid and (R)-(+)-3-(3,4-dihydroxyphenyl) lactic acid, describing its wide distribution in thirty-nine plant families and the potential productivity of plant sources.
    [Show full text]
  • Melanin-Related Molecules and Some Other New Agents Obtained from Natural Sources
    molecules Review Photoprotection and Skin Pigmentation: Melanin-Related Molecules and Some Other New Agents Obtained from Natural Sources Francisco Solano Department of Biochemistry and Molecular Biology B and Immunology, School of Medicine and LAIB-IMIB, University of Murcia, 30100 Murcia, Spain; [email protected] Received: 9 March 2020; Accepted: 25 March 2020; Published: 27 March 2020 Abstract: Direct sun exposure is one of the most aggressive factors for human skin. Sun radiation contains a range of the electromagnetic spectrum including UV light. In addition to the stratospheric ozone layer filtering the most harmful UVC, human skin contains a photoprotective pigment called melanin to protect from UVB, UVA, and blue visible light. This pigment is a redox UV-absorbing agent and functions as a shield to prevent direct UV action on the DNA of epidermal cells. In addition, melanin indirectly scavenges reactive oxygenated species (ROS) formed during the UV-inducing oxidative stress on the skin. The amounts of melanin in the skin depend on the phototype. In most phenotypes, endogenous melanin is not enough for full protection, especially in the summertime. Thus, photoprotective molecules should be added to commercial sunscreens. These molecules should show UV-absorbing capacity to complement the intrinsic photoprotection of the cutaneous natural pigment. This review deals with (a) the use of exogenous melanin or melanin-related compounds to mimic endogenous melanin and (b) the use of a number of natural compounds from plants and marine organisms that can act as UV filters and ROS scavengers. These agents have antioxidant properties, but this feature usually is associated to skin-lightening action.
    [Show full text]
  • Copyright @ School of Medicine and Pharmacy, VNU
    ĐẠI HỌC QUỐC GIA HÀ NỘI KHOA Y DƯỢC ---------- TRỊNH TRỌNG MINH NGHIÊN CỨU CHIẾT XUẤT, PHÂN LẬP MỘT SỐ HỢP CHẤT TỪ LÁ CÂY DÂU TẰM (Morus alba L.) KHÓA LUẬN TỐT NGHIỆP ĐẠI HỌC NGÀNH DƯỢC HỌC Hà Nội – 2018 Copyright @ School of Medicine and Pharmacy, VNU ĐẠI HỌC QUỐC GIA HÀ NỘI KHOA Y DƯỢC ---------- TRỊNH TRỌNG MINH NGHIÊN CỨU CHIẾT XUẤT, PHÂN LẬP MỘT SỐ HỢP CHẤT TỪ LÁ CÂY DÂU TẰM (Morus alba L.) KHÓA LUẬN TỐT NGHIỆP ĐẠI HỌC NGÀNH DƯỢC HỌC Khóa QH.2013.Y Người hướng dẫn: 1. TS. VŨ ĐỨC LỢI 2. PSG. TS. NGUYỄN TIẾN VỮNG Hà Nội – 2018 Copyright @ School of Medicine and Pharmacy, VNU LỜI CẢM ƠN Lời đầu tiên em xin bày tỏ lòng biết ơn chân thành và sâu sắc nhất tới TS. Vũ Đức Lợi – Chủ nhiệm Bộ môn dược liệu – Dược học cổ truyền, Khoa Y Dược - ĐHQGHN người đã trực tiếp hướng dẫn tận tình, chu đáo, tạo mọi điều kiện thuận lợi nhất cho em trong suốt thời gian thực hiện khóa luận, đồng thời góp ý kiến giúp em hoàn thành khóa luận này. Em xin cám ơn PGS.TS Nguyễn Tiến Vững – Viện Pháp y Quốc gia đã tận tình hướng dẫn, truyền đạt những kinh nghiệm quý báu cho em hoàn thành khóa luận. Em xin chân thành cảm ơn các thầy cô trong Bộ môn Dược liệu – Dược cổ truyền của Khoa Y Dược, Đại học Quốc gia Hà Nội đã tạo điều kiện thuận lợi, giúp đỡ em trong quá trình học tập và hoàn thành khóa luận tốt nghiệp.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2011/0224164 A1 Lebreton (43) Pub
    US 20110224164A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2011/0224164 A1 Lebreton (43) Pub. Date: Sep. 15, 2011 (54) FLUID COMPOSITIONS FOR IMPROVING Publication Classification SKIN CONDITIONS (51) Int. Cl. (75) Inventor: Pierre F. Lebreton, Annecy (FR) 3G 0.O :08: (73) Assignee: Allergan Industrie, SAS, Pringy (FR) (52) U.S. Cl. .......................................................... 514/54 (21)21) Appl. NoNo.: 12/777,1069 (57) ABSTRACT (22) Filed: May 10, 2010 The present specification discloses fluid compositions com O O prising a matrix polymerand stabilizing component, methods Related U.S. Application Data of making Such fluid compositions, and methods of treating (60) Provisional application No. 61/313,664, filed on Mar. skin conditions in an individual using Such fluid composi 12, 2010. tions. Patent Application Publication Sep. 15, 2011 Sheet 1 of 3 US 2011/0224164 A1 girl is" . .... i E.- &;',EE 3 isre. fire;Sigis's Patent Application Publication Sep. 15, 2011 Sheet 2 of 3 US 2011/0224164 A1 Wiscosity"in a a set g : i?vs. iii.tige: ssp. r. E. site is Patent Application Publication Sep. 15, 2011 Sheet 3 of 3 US 2011/0224164 A1 Fi; ; ; ; , ; i 3 -i-...-- m M mommam mm M. M. MS ' ' s 6. ;:S - - - is : s s: s e 3. 83 8 is is a is É . ; i: ; ------es----- .- mm M. Ma Yum YM Mm - m - -W Mmm-m a 'm m - - - S. 'm - i. So m m 3 - - - - - - - - --- f ; : : ---- ' - - - - - - - - - - - - - - - . : 2. ----------- US 2011/0224164 A1 Sep. 15, 2011 FLUID COMPOSITIONS FOR IMPROVING 0004. The fluid compositions disclosed in the present SKIN CONDITIONS specification achieve this goal.
    [Show full text]
  • In Silico, in Vitro and in Vivo Memory Enhancing Activity
    IN SILICO, IN VITRO AND IN VIVO MEMORY ENHANCING ACTIVITY OF CERTAIN COMMERCIALLY AVAILABLE FLAVONOIDS IN SCOPOLAMINE AND ALUMINIUM-INDUCED LEARNING IMPAIRMENT IN MICE Thesis submitted to The Tamil Nadu Dr. M.G.R. Medical University, Chennai for the award of the degree of DOCTOR OF PHILOSOPHY in PHARMACY Submitted by A. MADESWARAN, M. Pharm., Under the guidance of Dr. K. ASOK KUMAR, M. Pharm., Ph.D. College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore – 641 044, Tamil Nadu, India. JUNE 2017 Certificate This is to certify that the Ph.D. dissertation entitled “IN SILICO, IN VITRO AND IN VIVO MEMORY ENHANCING ACTIVITY OF CERTAIN COMMERCIALLY AVAILABLE FLAVONOIDS IN SCOPOLAMINE AND ALUMINIUM- INDUCED LEARNING IMPAIRMENT IN MICE” being submitted to The Tamil Nadu Dr. M.G.R. Medical University, Chennai, for the award of degree of DOCTOR OF PHILOSOPHY in the FACULTY OF PHARMACY was carried out by Mr. A. MADESWARAN, in College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, under my direct supervision and guidance to my fullest satisfaction. The contents of this thesis, in full or in parts, have not been submitted to any other Institute or University for the award of any degree or diploma. Dr. K. Asok Kumar, M.Pharm., Ph.D. Professor & Head, Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, Tamil Nadu - 641 044. Place: Coimbatore – 44. Date: Certificate This is to certify that the Ph.D. dissertation entitled “IN SILICO, IN VITRO AND IN VIVO MEMORY ENHANCING ACTIVITY OF CERTAIN COMMERCIALLY AVAILABLE FLAVONOIDS IN SCOPOLAMINE AND ALUMINIUM- INDUCED LEARNING IMPAIRMENT IN MICE” being submitted to The Tamil Nadu Dr.
    [Show full text]
  • Pharmacological Activity of Eriodictyol: the Major Natural Polyphenolic Flavanone
    Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2020, Article ID 6681352, 11 pages https://doi.org/10.1155/2020/6681352 Review Article Pharmacological Activity of Eriodictyol: The Major Natural Polyphenolic Flavanone Zirong Deng,1 Sabba Hassan,2 Muhammad Rafiq ,2 Hongshui Li,3 Yang He,4 Yi Cai,5 Xi Kang,6 Zhaoguo Liu ,1 and Tingdong Yan 1 1School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, China 2Department of Physiology and Biochemistry, Cholistan University of Veterinary and Animal Sciences (CUVAS), Bahawalpur 63100, Pakistan 3,e Second People Hospital of Dezhou, Dezhou 253022, China 4BayRay Innovation Center, Shenzhen Bay Laboratory, Shenzhen 518132, China 5Center of Pharmaceutical Research and Development, Guangzhou Medical University, Guangzhou, Guangdong 511436, China 6Center of Translational Medicine, Chemical Biology Institute, Shenzhen Bay Laboratory, Shenzhen 518132, China Correspondence should be addressed to Muhammad Rafiq; mrafi[email protected], Zhaoguo Liu; [email protected], and Tingdong Yan; [email protected] Received 22 October 2020; Revised 1 December 2020; Accepted 2 December 2020; Published 14 December 2020 Academic Editor: Hua Wu Copyright © 2020 Zirong Deng et al. 1is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Eriodictyol is a flavonoid that belongs to a subclass of flavanones and is widespread in citrus
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 9,359,622 B2 Hilmer Et Al
    US009359.622B2 (12) United States Patent (10) Patent No.: US 9,359,622 B2 Hilmer et al. (45) Date of Patent: Jun. 7, 2016 (54) METHOD FOR BOTECHNOLOGICAL (56) References Cited PRODUCTION OF DIHYDROCHALCONES U.S. PATENT DOCUMENTS (71) Applicant: Symrise AG, Holzminden (DE) 2005/02O8643 A1 9, 2005 Schmidt-Dannert et al. (72) Inventors: Jens Michael Hilmer, Holzminden OTHER PUBLICATIONS (DE); Egon Gross, Holzminden (DE); Chaparro-Riggers et al., Comparison of Three Enoate Reductases Gerhard Krammer, Holzminden (DE); and their Potential Use for Biotransformations, Adv. Synth. Catal. Jakob Peter Ley, Holzminden (DE); 2007, 349, 1521-31.* Mechthild Gall, Greifswald (DE); Uwe Ngaki et al., Evolution of the chalcone-isomerase fold from fatty-acid Bornscheuer, Griefswald (DE); Maren binding to stereospecific catalysis, Nature, May 2012, 485, 530-33 Thomsen, Greifswald (DE); Christin and Supplemental Information.* Peters, Greifswald (DE); Patrick Baldocket al., A Mechanism of Drug Action Revealed by Structural Jonczyk, Hannover (DE); Sascha Studies of Enoyl Reductase, Science, 1996, 274, 2107-10.* Uniprot, Accession No. V9P0A9, 2014. www.uniprot.org.* Beutel, Hannover (DE); Thomas Uniprot, Accession No. V9P074, 2014. www.uniprot.org.* Scheper, Hannover (DE) European Search Report dated Sep. 30, 2013. Schmidt, et al., “Biocatalytic Formation of a Bioactive (73) Assignee: SYMRISE AG, Holzminden (DE) Dihydrochalcone by Eubacterium Ramulus,” Journal of Biotechnol ogy, Elsevier Science Publishers, Amsterdam, NL, B.D. 150, Nov. 1, (*) Notice: Subject to any disclaimer, the term of this 2010, p. 150, XPO27489759. patent is extended or adjusted under 35 Schneider, et al., “Anaerobic Degradation of Flavonoids by U.S.C. 154(b) by 48 days.
    [Show full text]
  • Flavanone: a Versatile Heterocyclic Nucleus
    International Journal of ChemTech Research CODEN (USA): IJCRGG ISSN : 0974-4290 Vol.6, No.5, pp 3160-3178, Aug-Sept 2014 Flavanone: A Versatile Heterocyclic Nucleus Yogesh Murti* and Pradeep Mishra Institute of Pharmaceutical Research, GLA University, Mathura-281406 (U.P.), India *Corres.author: [email protected] Mobile: +91-8006240340, Fax No. +91-5662-241687 Abstract: The chemistry of heterocyclic compounds has been an interesting field of study for a long time. The present review article highlights different synthetic approaches to synthesize flavanone nucleus, natural and synthetic flavanones as well as recently synthesized flavanone possessing important biological activities. It was found that among the important pharmacophores responsible for various activities, flavanone also plays an important role in various medicines. Keywords: Chalcone, Flavanone, Heterocyclic compounds, Natural Flavanone, Synthetic flavanone, Biological activity. Introduction Flavonoids are extensive group of compounds occurring in plants. They are prominent plant secondary metabolites that have been found in dietary components including fruits, vegetables, olive oil, tea, and red wine. It has been observed that even a high take of plant based dietary flavonoids is safe and not associated with any adverse health effect. The basic flavanoid structure is a flavone nucleus, In nature, they are available as flavone, flavonol, flavanone, isoflavone, chalcone and their derivatives[1]. Figure 1: Molecular structure of the flavone backbone (2-Phenyl-1,4-benzopyrone
    [Show full text]