DOCSLIB.ORG

Progress Report 6/1/10 2009 Molecular Imaging Research Grant for Junior Medical Faculty Laura L

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Progress Report 6/1/10 2009 Molecular Imaging Research Grant for Junior Medical Faculty Laura L “Identifiers of Success” SNM/SNMTS Grants, Awards & Scholarship Programs funded by the Education and Research Foundation for SNM (ERF) SNM Mission: To improve healthcare by advancing molecular imaging and therapy. ERF Mission: To advance excellence in healthcare through the support of education and research in nuclear medicine and molecular imaging by provision of grants and awards. Grants, Awards & Scholarship Programs Overview Over the past five years the support received from the ERF has enabled SNM to offer a multitude of grants, awards and scholarship programs that mutually benefit and support the missions of both organizations; over $1 million has been distributed in the form of grants, awards, scholarships and continuing education initiatives to physicians, researchers, technologists and technologist students. A detailed list of programs awarded since 2006, and their funding levels, can be found on page 4 of this report. Grants, Awards & Scholarship Programs Highlights Approximately 200 individuals have attended SNM Annual Meetings in order to present their molecular imaging abstracts through the travel assistance received through the SNM/SNMTS Travel & Student Travel Awards. Contributors to the field of nuclear medicine/molecular imaging have been publicly recognized at the SNM Annual Meetings by way of the Mark Tetalman Award & the SNMTS Outstanding Technologist & Educator Awards. Over 150 nuclear medicine technologist students demonstrating academic excellence and financial need have received assistance through the Paul Cole Scholarship and have completed/nearly completed their certificate program, associates or bachelors degrees. Nearly 20 technologists have enrolled in/completed high-level/continuing education through the SNMTS Bachelors Degree Completion, Advanced Practitioner and Clinical Advancement Scholarships. SNM Student Fellowship Awards have given many students in medical school the opportunity to incorporate nuclear medicine/molecular imaging research into their curriculums and have paved the way for many of these students to enter residency programs in nuclear medicine/molecular imaging. These awards have also encouraged collaboration among various departments within institutions. Researchers who have received Seed/Pilot Research Grants have proceeded to extend their seed/pilot projects and have used their research results in applications for continuing grant funding to organizations such as the National Institutes of Health (NIH) and National Cancer Institutes (NCI). Resulting research abstracts have been presented at various SNM Annual Meetings and manuscripts have been published in the Journal of Nuclear Medicine and Cancer Biotherapy and radiopharmaceuticals. The molecular imaging focused awards introduced in 2008 (Molecular Imaging Research Grant for Junior Medical Faculty, Postdoctoral & Predoctoral Molecular Imaging Scholar Programs) have been considered “the highest academic recognition [that I have] ever earned” and have positively impacted the transition of fellows towards further career advancement. At the time of final report submission recipients reported: o Placement as an Investigator I in the department of Molecular Imaging at the Novartis Institute for Biomedical Research. o Various patents/patent applications. o Abstract presentations (both oral and poster) and Travel Awards to attend various international conferences such as the SNM Annual Meeting, World Molecular Imaging Congress Annual Meeting, and the Institute of Electrical & Electronics Engineers’ Nuclear Science Symposium & Molecular Imaging Conference. o Publications in media such as the Journal of Nuclear Medicine, Molecular Imaging, Cancer Research Journal, Protein Engineering Design and Selection, Physics in Medicine and Biology, and the IEEE Transactions on Nuclear Science. Grant Reporting Guidelines The following guidelines are distributed to all research grant recipients prior to their acceptance of an ERF-funded research grant: SNM Research Grant Report Guidelines Research grant recipients must: Provide the SNM Awards Committee with an interim report six months after the start of the project in the case of a one-year award. Two-year awards must submit the interim report one year after the start of the project. Provide the SNM Awards Committee a final report within 6-8 weeks after project completion, depending on requirements stated in the information accompanying the application. Report Requirements Interim and Final Reports Interim report—3 pp. maximum. Final report—10 pages maximum. Summary statement not to exceed one page—one half page preferred. Restate goal. Restate specific aims and the results of your work toward each aim. Include relevant supporting data. Identify and justify any deviations from the original plan. Summarize expenditures. Explain the problems you have encountered and how they impacted the plan. Additional Requirements for the Final Report Identify any of the original goals you did not reach and explain why. Indicate the future clinical significance from the results of your research. Indicate if the results from your research will o Be submitted for publication. o Be used as preliminary data in a grant application to another granting agency. In the final report, we also urge you to Tell us if the grant helped influence your career and/or its future Suggest how to improve the grant program The SNM is able to provide research grant support because of generous support from individual donors and the generosity of the Education and Research Foundation for SNM. To provide feedback on the impact of our grant programs to our donors, we may ask you to participate in a future survey to track your career advancements, publications, and future grant support. The remainder of this report contains a compilation of the research grant reports that have been collected since 2006. In addition to the research grant reports received a tool that would prove useful to both SNM & ERF is a survey to previous grant/award/scholarship recipients. Potential survey questions can be found on the following page. Example: Grant, Award, & Scholarship Recipient Survey/Questionnaire General Information 1. Name: 2. Email: 3. Phone: 4. Degrees Received: 5. Current Institution: 6. Current Title: Award Information 1. SNM Award(s) Received (radio-button list with options) 2. Additional Questions depending on type of Award Received (see below) 3. Please feel free to provide any additional comments regarding your SNM award and the SNM grants & awards programs. Additional Questions: Scholarships/Student Fellowships Did you graduate/are you on track to graduate from your degree program? Y / N- If N, please explain. How did you use the scholarship funds? tuition/supplies/living expenses Travel Awards How many abstracts did you present at the SNM Annual Meeting during your award year? 1,2,3,4,5+ Did this/these abstracts result in any awards at the SNM Annual Meeting? Y /N- If Y, please list. Please indicate which recent SNM Annual Meetings you have attended. 2006,2007,2008,2009,2010 Are you planning on attending the 2011 SNM Annual Meeting in San Antonio, Texas? Y / N Does your institution/organization budget for your attendance to the SNM Annual Meeting? Y / N Did receiving the Travel Award make a large contribution to your being able to attend the SNM Annual Meeting? Y / N Research Grants Were you able to complete your research project? Y / N- If N, please explain. Where you able to accomplish your research goals during the given grant period? Y / N- If N, please explain. Do you believe that your research accomplishments made possible through the SNM research grant positively impacted your career? Y / N If Yes, in what ways did the SNM research grant impact your career? If No, why do you believe your SNM research grant did not impact your career? Did you attend/are you planning to attend a SNM Annual Meeting to present your research abstract resulting from your SNM research grant accomplishments? Y / N Did any scientific publications, presentations, or awards result from your research accomplishments made possible through the SNM research grant? Y / N- If Yes, please list. ERF-Funded SNM/SNMTS Programs 2006-2009 2006 # of awards amount total 2007 # of awards amount total SNM/GE Visiting Physician/Scientist Program Grant for China & India 3 $10,000 $30,000 Mallinkrodt Seed Grant 1 $25,000 $25,000 Mallinkrodt Seed Grant 1 $25,000 $25,000 Mallinkrodt Pilot Research Grant 1 $10,000 $10,000 Pilot Research Grants 4 $8,000 $32,000 Mitzi & William Blahd Pilot Research Grant 1 $10,000 $10,000 Student Fellowship Awards 5 $3,000 $15,000 Pilot Research Grants 5 $8,000 $40,000 Alavi Mandell Publication Awards 16 $150 $2,400 Student Fellowship Awards 5 $3,000 $15,000 Mark Tetalman Award 1 $2,500 $2,500 Alavi Mandell Publication Awards 16 $150 $2,400 SNMTS Paul Cole Scholarships 30 $1,000 $30,000 Mark Tetalman Award 1 $5,000 $5,000 $136,900 SNMTS Paul Cole Scholarships 30 $1,000 $30,000 SNMTS Best Paper Award 1 $500 $500 SNMTS Outstanding Technologist Award 1 $750 $750 SNMTS Outstanding Educator Award 1 $750 $750 $139,400 2008 # of awards amount total 2009 # of awards amount total 2008-2010 Molecular Imaging Research Grant for 2009-2011 Molecular Imaging Research Grant for Junior Medical Faculty 1 $50,000 $50,000 Junior Medical Faculty 1 $50,000 $50,000 2008-2010 Postdoctoral Molecular Imaging Scholar 2009-2011 Postdoctoral Molecular Imaging Scholar Program 2 $30,000 $60,000 Program 1 $30,000 $30,000 2008-2010 Predoctoral Moelcular
Load more

Recommended publications
  • United States Patent (19) 11 Patent Number: 5,902,815 Olney Et Al
    USOO5902815A United States Patent (19) 11 Patent Number: 5,902,815 Olney et al. (45) Date of Patent: May 11, 1999 54 USE OF 5HT2A SEROTONIN AGONISTS TO Hougaku, H. et al., “Therapeutic effect of lisuride maleate on PREVENT ADVERSE EFFECTS OF NMDA post-stroke depression” Nippon Ronen Igakkai ZaSShi 31: RECEPTOR HYPOFUNCTION 52-9 (1994) (abstract). Kehne, J.H. et al., “Preclinical Characterization of the Poten 75 Inventors: John W. Olney, Ladue; Nuri B. tial of the Putative Atypical Antipsychotic MDL 100,907 as Farber, University City, both of Mo. a Potent 5-HT2A Antagonist with a Favorable CNS Saftey Profile.” The Journal of Pharmacology and Experimental 73 Assignee: Washington University, St. Louis, Mo. Therapuetics 277: 968–981 (1996). Maurel-Remy, S. et al., “Blockade of phencyclidine-induced 21 Appl. No.: 08/709,222 hyperlocomotion by clozapine and MDL 100,907 in rats reflects antagonism of 5-HT2A receptors' European Jour 22 Filed: Sep. 3, 1996 nal of Pharmacology 280: R9–R11 (1995). 51) Int. Cl. ........................ A61K 31/445; A61K 31/54; Olney, J.W., et al., “NMDAantagonist neurotoxicity: Mecha A61K 31/135 nism and prevention,” Science 254: 1515–1518 (1991). 52 U.S. Cl. .......................... 514/285; 514/315; 514/318; Olney, J.W., et al., “Glutamate receptor dysfunction and 514/646 schizophrenia.” Arch. Gen. Psychiatry 52:998-1007 (1995). 58 Field of Search ............................. 514/285; 314/315, Pulvirenti, L. et al., “Dopamine receptor agonists, partial 314/318, 646 agonists and psychostimulant addiction' Trends Pharmacol Sci 15: 374-9 (1994). 56) References Cited Robles, R.G. et al., “Natriuretic Effects of Dopamine Agonist Drugs in Models of Reduced Renal Mass” Journal of U.S.
    [Show full text]
  • Fushi-Tarazu During Segmentation
    Proc. Natl. Acad. Sci. USA Vol. 92, pp. 5441-5445, June 1995 Developmental Biology Drosophila 5-HT2 serotonin receptor: Coexpression with fushi-tarazu during segmentation (in situ hybridization/G protein-coupled receptors/pair-rule gene) JEAN-FRAN;OIS CoLAs*, JEAN-MARIE LAUNAYt, ODILE KELLERMANNt, PHILIPPE ROSAY*, AND Luc MAROTEAUX*§ *Institut de Genetique et de Biologie Mol6culaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite de Strasbourg, BP 163, 67404 Illkirch Cedex, France; tH6pital Lariboisiere, Service de Biochimie, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France; and tDepartement de Biologie Moleculaire, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France Communicated by Walter J. Gehring, University ofBasel, Basel, Switzerland, March 6, 1995 (received for review December 5, 1994) ABSTRACT Serotonin, first described as a neurotrans- ergic neurons (6), and to incomplete sclerotization of the mitter in invertebrates, has been investigated mostly for its cuticule (3). functions in the mature central nervous system of higher We report the characterization of a Drosophila serotonin vertebrates. Serotonin receptor diversity has been described receptor that displays a typical 5-HT2 receptor sequence, gene in the mammalian brain and in insects. We report the isolation organization, and pharmacology.5 It is expressed in the central of a cDNA coding for a Drosophila melanogaster serotonin nervous system (CNS) during larval and adult stages. More receptor that displays a sequence, a gene organization, and surprisingly, this receptor is expressed at the blastoderm stage pharmacological properties typical of the mammalian 5-HT2 of embryogenesis in a pattern similar to that of the pair-rule serotonin receptor subtype.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness Et Al
    USOO6264,917B1 (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness et al. (45) Date of Patent: Jul. 24, 2001 (54) TARGETED ULTRASOUND CONTRAST 5,733,572 3/1998 Unger et al.. AGENTS 5,780,010 7/1998 Lanza et al. 5,846,517 12/1998 Unger .................................. 424/9.52 (75) Inventors: Jo Klaveness; Pál Rongved; Dagfinn 5,849,727 12/1998 Porter et al. ......................... 514/156 Lovhaug, all of Oslo (NO) 5,910,300 6/1999 Tournier et al. .................... 424/9.34 FOREIGN PATENT DOCUMENTS (73) Assignee: Nycomed Imaging AS, Oslo (NO) 2 145 SOS 4/1994 (CA). (*) Notice: Subject to any disclaimer, the term of this 19 626 530 1/1998 (DE). patent is extended or adjusted under 35 O 727 225 8/1996 (EP). U.S.C. 154(b) by 0 days. WO91/15244 10/1991 (WO). WO 93/20802 10/1993 (WO). WO 94/07539 4/1994 (WO). (21) Appl. No.: 08/958,993 WO 94/28873 12/1994 (WO). WO 94/28874 12/1994 (WO). (22) Filed: Oct. 28, 1997 WO95/03356 2/1995 (WO). WO95/03357 2/1995 (WO). Related U.S. Application Data WO95/07072 3/1995 (WO). (60) Provisional application No. 60/049.264, filed on Jun. 7, WO95/15118 6/1995 (WO). 1997, provisional application No. 60/049,265, filed on Jun. WO 96/39149 12/1996 (WO). 7, 1997, and provisional application No. 60/049.268, filed WO 96/40277 12/1996 (WO). on Jun. 7, 1997. WO 96/40285 12/1996 (WO). (30) Foreign Application Priority Data WO 96/41647 12/1996 (WO).
    [Show full text]
  • Decrease in Brain Serotonin 2 Receptor Binding In
    ORIGINAL ARTICLE Decrease in Brain Serotonin 2 Receptor Binding in Patients With Major Depression Following Desipramine Treatment A Positron Emission Tomography Study With Fluorine-18–Labeled Setoperone Lakshmi N. Yatham, MBBS, FRCPC; Peter F. Liddle, PhD, MBBS; Joelle Dennie, MSc; I-Shin Shiah, MD; Michael J. Adam, PhD; Carol J. Lane, MSc; Raymond W. Lam, MD; Thomas J. Ruth, PhD Background: The neuroreceptor changes involved in Results: Eight of the 10 patients responded to desipra- therapeutic efficacy of various antidepressants remain un- mine treatment as indicated by more than 50% decrease clear. Preclinical studies have shown that long-term ad- in Hamilton Depression Rating Scale scores. Depressed ministration of various antidepressants causes down- patients showed a significant decrease in 5-HT2 recep- regulation of brain serotonin 2 (5-HT2) receptors in rodents, tor binding as measured by setoperone binding in fron- but it is unknown if similar changes occur following anti- tal, temporal, parietal, and occipital cortical regions fol- depressant treatment in depressed patients. Our purpose, lowing desipramine treatment. The decrease in 5-HT2 therefore, was to assess the effects of treatment with desi- receptor binding was observed bilaterally and was par- pramine hydrochloride on brain 5-HT2 receptors in de- ticularly prominent in frontal cortex. pressed patients using positron emission tomography (PET) and fluorine-18 (18F)–labeled setoperone. Conclusions: Depressed patients showed a significant reduction in available 5-HT2 receptors in the brain fol- Methods: Eleven patients who met DSM-IV criteria for lowing desipramine treatment, but it is unknown if this major depression as determined by a structured clinical change in 5-HT2 receptors is due to clinical improve- interview for DSM-III-R diagnosis and suitable for treat- ment or an effect of desipramine that is unrelated to clini- ment with desipramine were recruited.
    [Show full text]
  • A New Framework for Investigating Antipsychotic Action in Humans: Lessons from PET Imaging S Kapur
    Molecular Psychiatry (1998) 3, 135–140 1998 Stockton Press All rights reserved 1359–4184/98 $12.00 PERSPECTIVE A new framework for investigating antipsychotic action in humans: lessons from PET imaging S Kapur Schizophrenia Division and the PET Centre, The Clarke Institute of Psychiatry, Department of Psychiatry, University of Toronto; Rotman Research Institute, Baycrest Centre, University of Toronto With a decade of neuroreceptor imaging of antipsychotics behind us, this article attempts to synthesise what has been learnt about the mechanism of action of antipsychotics using these techniques. The data show that: (i) the ‘typical’ antipsychotics bind mainly to the dopamine D2 receptor, and that 60–80% D2 occupancy may provide optimal antipsychotic response with little extrapyramidal side effects; (ii) all the clinically available ‘atypical’ antipsychotics show a higher occupancy of the 5-HT2 than D2 receptors; (iii) however, these ‘atypical’ antipsy- chotics differ in their D2 occupancy. The D2 occupancy of risperidone is within the typical range (ie Ͼ 60%) while that of clozapine is clearly lower (Ͻ60%); (iv) antipsychotics with com- bined 5-HT2/D2 antagonism lose some of their ‘atypical’ properties if used in doses where Ͼ their D2 occupancy is too high ( 80%). Based on these data a framework is suggested wherein antipsychotics may be classified on the basis of their D2 and 5-HT2 occupancy in patients at steady state while taking clinically relevant doses. Within this framework typical antipsy- chotics are classified as ‘high-D2’, risperidone as ‘high-D2 high-5HT2’ and clozapine as a ‘low- D2 high-5HT2’ antipsychotic. The justification, limitations and the value of this framework in understanding and investigating newer antipsychotics is discussed.
    [Show full text]
  • Name and Address of the Sponsor and Monitor
    PROTOCOL SCRIPT PROTOCOL FULL TITLE: A randomised, balanced, double-blind two-way crossover design study to evaluate the effects of SRC kinase inhibitor, Saracatinib, on brain activity associated with visual processing in patients with Parkinson’s disease Psychosis. Protocol Short Title/Acronym: SRC inhibition as a potential target for Parkinson’s disease psychosis- SCRIPT Trial Identifiers REC Number – [Awaiting further information] Co-Sponsors: King’s College London & Kings College Hospital NHS trust Chief Investigator Name: Professor Mitul Mehta Address: Department of Neuroimaging, Institute of Psychology, Psychiatry and Neuroscience, King’s College London, London SE5 8AF Telephone: +44 (0) 2032283053 Email: [email protected] Name and address of Co-Investigator(s), Statistician, Laboratories etc Name: Dr Dominic ffytche Address: Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF Telephone: Fax: Protocol Version 2.2 23/08//2018 Page 1 of 49 IRAS ID: 247303 PROTOCOL SCRIPT Email: [email protected] Name: Professor K Ray Chaudhuri Address: Dept. Basic and Clinical Neuroscience, The Maurice Wohl Clinical Neuroscience Institute, King's College London, Cutcombe Road, London SE5 9RT Telephone: Fax: Email: [email protected] Name: Professor Dag Aarsland Address: Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF Telephone: Fax: Email: [email protected] Protocol Version 2.2 23/08//2018 Page 2 of 49 IRAS ID: 247303 PROTOCOL SCRIPT 1. Study Synopsis Title of clinical trial A randomised, balanced, double-blind two-way crossover design study to evaluate the effects of SRC kinase inhibitor, Saracatinib, on brain activity associated with visual processing in patients with Parkinson’s disease Psychosis.
    [Show full text]
  • Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
    20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0
    [Show full text]
  • Clinical Pharmacokinetics 41
    Clin Pharmacokinet 2002; 41 (8): 581-602 CONCEPTS 0312-5963/02/0008-0581/$25.00/0 © Adis International Limited. All rights reserved. Pharmacokinetic Imaging A Noninvasive Method for Determining Drug Distribution and Action Alan J. Fischman,1,2 Nathaniel M. Alpert1 and Robert H. Rubin1,2 1 Division of Nuclear Medicine of the Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA 2 Division of Health Sciences and Technology, Center for Experimental Pharmacology and Therapeutics, Harvard-Massachusetts Institute of Technology, Cambridge, Massachusetts, USA Contents Abstract . 581 1. Radionuclide Imaging Techniques . 583 1.1 Instrumentation . 583 1.2 Tracer Techniques . 584 1.3 Radiochemistry . 585 1.4 Advantages and Limitations of Positron Emission Tomography Measurements . 585 2. Types of Studies with Positron Emission Tomography . 586 2.1 Antimicrobial Agents . 587 2.1.1 Erythromycin . 588 2.1.2 Fluconazole . 588 2.1.3 Fluoroquinolones . 589 2.2 CNS Drugs . 590 3. Pharmacodynamics . 594 4. Magnetic Resonance Spectroscopy . 597 4.1 Antineoplastic Drugs . 597 4.2 Antimicrobial Agents . 598 4.3 CNS Drugs . 598 5. Conclusions . 599 Abstract Advances in positron emission tomography (PET), single photon emission computed tomography (SPECT) and magnetic resonance spectroscopy (MRS), and the ability to label a wide variety of compounds for in vivo use in humans, have created a new technology for making precise physiological and pharma- cological measurements. Due to the noninvasive nature of these approaches, re- petitive and/or continuous measurements have become possible. Thus far, these techniques have been primarily used for one-time assessments of individuals. However, experience suggests that a major use of this technology will be in the evaluation of new drug therapies.
    [Show full text]
  • A Positron Emission Tomography Study Of
    ORIGINAL ARTICLE A Positron Emission Tomography Study of Quetiapine in Schizophrenia A Preliminary Finding of an Antipsychotic Effect With Only Transiently High Dopamine D2 Receptor Occupancy Shitij Kapur, MD, PhD, FRCPC; Robert Zipursky, MD, FRCPC; Corey Jones, BSc; C. S. Shammi, MD, FRCPC; Gary Remington, MD, PhD, FRCPC; Philip Seeman, MD, PhD Background: Quetiapine is a new atypical antipsy- lactin level elevation noted at baseline. It achieved chotic medication. As such, relatively little has been pub- these results with minimal (0%-27%) D2 occupancy 12 lished regarding its in vivo effects at the dopamine type hours after the last dose. Study of the additional sub- 2(D2) and serotonin type 2a (5-HT2a) receptor systems. jects revealed that quetiapine does give rise to tran- The following study was undertaken to explore these ef- siently high (58%-64%) D2 occupancy 2 to 3 hours fects across the clinical dose range and relate this infor- after a single dose that then decreases to minimal lev- mation to its clinical profile. els in 12 hours. Methods: Twelve patients with schizophrenia were ran- Conclusions: Quetiapine shows a transiently high D2 domly assigned to doses of 150 to 600 mg/d (n=3, at 150, occupancy, which decreases to very low levels by the 300, 450, and 600 mg/d) of quetiapine. After 3 weeks of end of the dosing interval. Quetiapine’s low D2 occu- treatment, D2 and 5-HT2a occupancy were measured us- pancy can explain its freedom from extrapyramidal ing positron emission tomography (PET) imaging, 12 to symptoms and prolactin level elevation.
    [Show full text]
  • Drug Development in Alzheimer's Disease: the Contribution of PET and SPECT
    fphar-07-00088 March 29, 2016 Time: 15:21 # 1 View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Frontiers - Publisher Connector REVIEW published: 31 March 2016 doi: 10.3389/fphar.2016.00088 Drug Development in Alzheimer’s Disease: The Contribution of PET and SPECT Lieven D. Declercq1, Rik Vandenberghe2, Koen Van Laere3, Alfons Verbruggen1 and Guy Bormans1* 1 Laboratory for Radiopharmacy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium, 2 Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium, 3 Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium Clinical trials aiming to develop disease-altering drugs for Alzheimer’s disease (AD), a neurodegenerative disorder with devastating consequences, are failing at an alarming rate. Poorly defined inclusion-and outcome criteria, due to a limited amount of objective biomarkers, is one of the major concerns. Non-invasive molecular imaging techniques, positron emission tomography and single photon emission (computed) tomography (PET and SPE(C)T), allow visualization and quantification of a wide variety of (patho)physiological processes and allow early (differential) diagnosis in many disorders. Edited by: Albert D. Windhorst, PET and SPECT have the ability to provide biomarkers that permit spatial assessment VU University Medical Center, of pathophysiological molecular changes and therefore objectively evaluate and follow Netherlands up therapeutic response, especially in the brain. A number of specific PET/SPECT Reviewed by: biomarkers used in support of emerging clinical therapies in AD are discussed in this Bashir M. Rezk, Southern University at New Orleans, review.
    [Show full text]
  • Stembook 2018.Pdf
    The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.
    [Show full text]
  • New Information of Dopaminergic Agents Based on Quantum Chemistry Calculations Guillermo Goode‑Romero1*, Ulrika Winnberg2, Laura Domínguez1, Ilich A
    www.nature.com/scientificreports OPEN New information of dopaminergic agents based on quantum chemistry calculations Guillermo Goode‑Romero1*, Ulrika Winnberg2, Laura Domínguez1, Ilich A. Ibarra3, Rubicelia Vargas4, Elisabeth Winnberg5 & Ana Martínez6* Dopamine is an important neurotransmitter that plays a key role in a wide range of both locomotive and cognitive functions in humans. Disturbances on the dopaminergic system cause, among others, psychosis, Parkinson’s disease and Huntington’s disease. Antipsychotics are drugs that interact primarily with the dopamine receptors and are thus important for the control of psychosis and related disorders. These drugs function as agonists or antagonists and are classifed as such in the literature. However, there is still much to learn about the underlying mechanism of action of these drugs. The goal of this investigation is to analyze the intrinsic chemical reactivity, more specifcally, the electron donor–acceptor capacity of 217 molecules used as dopaminergic substances, particularly focusing on drugs used to treat psychosis. We analyzed 86 molecules categorized as agonists and 131 molecules classifed as antagonists, applying Density Functional Theory calculations. Results show that most of the agonists are electron donors, as is dopamine, whereas most of the antagonists are electron acceptors. Therefore, a new characterization based on the electron transfer capacity is proposed in this study. This new classifcation can guide the clinical decision‑making process based on the physiopathological knowledge of the dopaminergic diseases. During the second half of the last century, a movement referred to as the third revolution in psychiatry emerged, directly related to the development of new antipsychotic drugs for the treatment of psychosis.
    [Show full text]