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A Collaborative Annotation Environment for Structural Genomics
Weekes et al. BMC Bioinformatics 2010, 11:426 http://www.biomedcentral.com/1471-2105/11/426 METHODOLOGY ARTICLE Open Access TOPSAN: a collaborative annotation environment for structural genomics Dana Weekes1†, S Sri Krishna1†, Constantina Bakolitsa1, Ian A Wilson2, Adam Godzik1,3,4*, John Wooley1,3* Abstract Background: Many protein structures determined in high-throughput structural genomics centers, despite their significant novelty and importance, are available only as PDB depositions and are not accompanied by a peer- reviewed manuscript. Because of this they are not accessible by the standard tools of literature searches, remaining underutilized by the broad biological community. Results: To address this issue we have developed TOPSAN, The Open Protein Structure Annotation Network, a web-based platform that combines the openness of the wiki model with the quality control of scientific communication. TOPSAN enables research collaborations and scientific dialogue among globally distributed participants, the results of which are reviewed by experts and eventually validated by peer review. The immediate goal of TOPSAN is to harness the combined experience, knowledge, and data from such collaborations in order to enhance the impact of the astonishing number and diversity of structures being determined by structural genomics centers and high-throughput structural biology. Conclusions: TOPSAN combines features of automated annotation databases and formal, peer-reviewed scientific research literature, providing an ideal vehicle to bridge -
A Warm Friend of Israel
A War m Friend of Isr ael • A Warm Friend of Isr ael HERBERT W. ARMSTRONG The Ambassador Without Portfolio • a Climbing aboard the Gulfstream II aircraft on one of numerous trips in the 1970s to visit world leaders. The ‘Unofficial A m b a ss a d or for World Peace’ e had no political party, no royal office,• no government Hcommission. He possessed no personal fortune, nor was he backed by any state or corporate interest. Yet he met personally with dozens of heads of state: prime minis- ters, presidents, kings, emperors, princes and princesses—as well as legislators, ambassadors, cabinet ministers, first ladies, governors, mayors, generals, chief executives, judges and other leaders of government and industry. Flying across the globe in his plane like a shuttle diplomat, this private citizen met with British Prime Minister Margaret Thatcher; King Leopold of Belgium; American First Lady Nancy Reagan; Chinese Premier Deng Xiaoping; Ethiopian Emperor Haile Selassie; Jordan’s King Hussein; Egyptian presi- dents Anwar Sadat and Hosni Mubarak; and the emperor, crown prince and seven successive prime ministers of Japan. In between, he met the presidents, prime ministers, and/or kings of Spain, the Philippines, India, Indonesia, Thailand, Nepal, Sri Lanka, Lebanon, Bangladesh, South Africa, Kenya and Chile— and ambassadors from dozens more countries. Oftentimes at banquets and meetings between such luminaries and himself, it was the latter who was the keynote speaker or the guest of honor. Most of these leaders knew his work and his message, many 1 a Mr. Armstrong meets with First Lady Nancy Reagan in the White House in 1985. -
Structural and Molecular Basis of Mismatch Correction and Ribavirin Excision from Coronavirus RNA
Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA François Ferrona,1, Lorenzo Subissia,1, Ana Theresa Silveira De Moraisa,1, Nhung Thi Tuyet Lea, Marion Sevajola, Laure Gluaisa, Etienne Decrolya, Clemens Vonrheinb, Gérard Bricogneb, Bruno Canarda,2, and Isabelle Imberta,2,3 aCentre National de la Recherche Scientifique, Aix-Marseille Université, CNRS UMR 7257, Architecture et Fonction des Macromolécules Biologiques, 13009 Marseille, France; and bGlobal Phasing Ltd., Cambridge CB3 0AX, England Edited by Peter Palese, Icahn School of Medicine at Mount Sinai, New York, NY, and approved December 1, 2017 (received for review October 30, 2017) Coronaviruses (CoVs) stand out among RNA viruses because of their CoVs include two highly pathogenic viruses responsible for unusually large genomes (∼30 kb) associated with low mutation severe acute respiratory syndrome (SARS) (12) and Middle East rates. CoVs code for nsp14, a bifunctional enzyme carrying RNA respiratory syndrome (MERS) (13), for which neither treatment cap guanine N7-methyltransferase (MTase) and 3′-5′ exoribonu- nor a vaccine is available. They possess the largest genome clease (ExoN) activities. ExoN excises nucleotide mismatches at the among RNA viruses. The CoV single-stranded (+) RNA genome RNA 3′-end in vitro, and its inactivation in vivo jeopardizes viral carries a 5′-cap structure and a 3′-poly (A) tail (14). Replication genetic stability. Here, we demonstrate for severe acute respiratory and transcription of the genome are achieved by a complex RNA syndrome (SARS)-CoV an RNA synthesis and proofreading pathway replication/transcription machinery, made up of at least of 16 viral through association of nsp14 with the low-fidelity nsp12 viral RNA nonstructural proteins (nsps). -
Who's Who in World Je First International Conference Jerusale Founders Assembly the Jewish Hall of Fa1-I.E
WHO'S WHO IN WORLD JE FIRST INTERNATIONAL CONFERENCE JERUSALE FOUNDERS ASSEMBLY THE JEWISH HALL OF FA1-I.E PATRON The Honorable Ephraim Katrir President of the State of Israel December 20 1976 Office of the President and EDITORIAL BOARD Chairman of the Editorial Board Dr. I. J. Cam-tin Karpman Chairman I. J. Carmin Karpman General Editor The Standard Jewish Encyclopedia Mr. Irving Louis ,Chairman Anatole A. Yaron Executive Director, Who's Who in World Jewry Dap* of Sociology Dr. Avraham Avi-hai, JerusaJem Livingston Collage Lecturer. Political Science Bar Han University Rutgers University, Mr. Irving Bernstein, New York Nev Brunswick N.J. 08903 Executive Vice Chairman United Jewish Appeal Dr Israel Bilecky, Tel Aviv Dear Sir: Lecturer, Yiddish Literature Tel Aviv University Mr. Solon Myles Chadabe, New York Member, Board of Directors You are cordially invited to join the Honorary Advisory Board of National Federations of Temple Brrtthertt-ootk the proposed JEWISH HALL OF FAME to be established in Jerusalem Mr. Bernard Cherrick, Jerusalem Vice President under the auspices of WHO'S "WHO IN WORLD JEWRY. Panels of experts Hebrew University Mr. Seymour Fishman. New York are being constituted to plan the monumental JEWISH HALL OF FAME Executive Vice President as a repository of Jewish heritage and knowledge and as an expression American Friends of the Hebrew University Mr. Arnold Forster, New York of the Jewish contribution to the progress of mankind in all fields General Counsel, A nti-Defamation of human endeavor. League of B'nai B'rith Mr. Bertram H. Gold, New York Executive Vice President The President of Israel, the Honorable Professor Ephraim Katzir, The American Jewish Committee Patron of WHO'S WHO IN WORLD JEWRY, endorsed the project, stating: I Mr. -
Who's Who Im World Jewry First International Conference Jerusalem Founders Assembly the Jewish Hall of Fame
WHO'S WHO IM WORLD JEWRY FIRST INTERNATIONAL CONFERENCE JERUSALEM FOUNDERS ASSEMBLY THE JEWISH HALL OF FAME PATRON The Honorable Ephraim Katzir December 20 1976 President of the State of Israel Office of the President and EDITORIAL BOARD Chairman of the Editorial Board Dr. I. J. Carmin Karpman I. J. Carmin Karpman Chairman Mr. Artur Rubinstein,Pianist Virtuoso General Editor 22 Sq de L’Avenue Foch, The Standard Jewish Encyclopedia Paris, I6l eme, Anatole A. Yaron Executive Director, Who's Who in World Jewry France Dr. Avraham Avi-hai, Jerusalem Lecturer, Political Science Bar Ilan University Mr. Irving Bernstein, New York Executive' Vice Chairman United Jewish Appeal Dear Sir: Dr. Israel Bilecky, Tel Aviv Lecturer, Yiddish Literature Tel Aviv University Mr. Solon Myles Chadabe, New York Member, Board of Directors You are cordially invited to join the Honorary Advisory Board of National Federations of Temple Brotherhoods the proposed JEWISH HALL OF FAME to be established in Jerusalem Mr. Bernard Cherrick, Jerusalem Vice President under the auspices of WHO’S WHO IN WORLD JEWRY. Panels of experts Hebrew University are being constituted to plan the monumental JEWISH HALL OF FAME Mr. Seymour Fishman, New York Executive Vice President as a repository of Jewish heritage and knowledge and as an expression American Friends of the Hebrew University of the Jewish contribution to the progress of mankind in all fields Mr. Arnold Forster, New York General Counsel, Anti-Defamation of human endeavor. League of B'nai B'rith Mr. Bertram H. Gold, New York The President of Israel, the Honorable Professor Ephraim Katzir, Executive Vice President The American Jewish Committee Patron of WHO’S WHO IN WORLD JEWRY, endorsed the project, stating: Mr. -
Visualization of Macromolecular Structures
REVIEW Visualization of macromolecular structures Seán I O’Donoghue1, David S Goodsell2, Achilleas S Frangakis3, Fabrice Jossinet4, Roman A Laskowski5, Michael Nilges6, Helen R Saibil7, Andrea Schafferhans1, Rebecca C Wade8, Eric Westhof4 & Arthur J Olson2 Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools. Decades ago, when structural biology was still in its most of them are not prepared to spend months learn- infancy, structures were rare and structural biologists ing complex user interfaces or scripting languages. often dedicated years of their life to studying just one Even today, complex user interfaces in visualization structure at atomic detail. The first tools used for visualiz- tools are often a stumbling block, preventing many ing macromolecular structures were tools for specialists. scientists from benefiting from structural data. Even Today’s situation is very different: the rate at which structural experts have come to expect ease of use from structures are solved has greatly increased, with over molecular graphics tools, in addition to improved 60,000 high-resolution protein structures now avail- speed, features and capabilities. able in the consolidated Worldwide Protein Data Bank In the past, molecular graphics tools were invariably (wwPDB)1. -
August 4, 1977
.... ---~.. .,. .. _;::_::_:;:....:: .:=:::.::::::::==::::::-:--:-::===::!::;::::=-::--=""'"·-_-_-_-__~_,-::-. ..._- ::~.::--_-__- __- __-:- __-_~__ _..,_ .-~ _..._- __:_":_:_":_".'... __ __-__- _"!'_ -_-__:: _·_~ . =.::.:-_::_:-:_=-=·=--=--::::.:::..=--=-====~===:::::::=:::::::;:==- --,~ HISTORICAL ASSOC. 1,\ R.I. JEWISH 130 SESSIONS ST. P ROVIDENCE , RI 02906 v Support Read By Jewish ... More Than Agencies 35,000 With Your People Membership THE ONLY ENGLIS H JEWIS H W EEKLY IN R. I AND SOUTHEAST MASS. VOLUME LX, NUMBER 22 THURSDAY, '.",UGUST 4, 1977 16 PAGES 25¢ PER COPY Providence Hebrew Day ..School Appoints Assistant Principal The Providence Hebrew Day School has anno1U1ced the appointment of Rabbi Kopi Saltman as assistant principal of the Hebre,y Department. Rabbi Saltman comes lo the school with an extensive background in both Hebrew and secular education, hav ing served as principal of the Max Gilbert Hebrew Academy, Syracuse, ·New York, for the past five years. •-While in · Syracuse,- he was awarded a. N~ York State mini-grant for a creative teiching proposal, and also a grant from the local Roth Foundation to develop the Bi6Uh:urri'culum. Active in the educational community, he was a member of the Syracuse Jewish Principal's Association, and served as co-chairman for one year . Rabbi Saltman was born in Holyoke, Massachusetts, and attended Yeshiva University from high school through or dination. While at . Yeshiva University he was awarded the General Motors College Scholarship. He received his MA from Ber RABBIKOPISALTMAN nard Revel Graduate School in Talmudic Literature and bas taken graduate courses administrator's certificate in the fall, . -
A Novel Approach for Protein Structure Prediction
A Novel Approach for Protein Structure Prediction The Project Report is submitted in partial fulfillment of the requirements for the award of the degree of BACHELOR OF TECHNOLOGY Submitted By: (Saurabh Sarkar, Prateek Malhotra, Virender Guman) Department of Computer Science & Engineering G.L.Bajaj Institute of Technology & Mgmt. Greater Noida Uttar Pradesh Technical University Lucknow (U. P.) India A Novel Approach for Protein Structure Prediction The Project Report is submitted in partial fulfillment of the requirements for the award of the degree of BACHELOR OF TECHNOLOGY Submitted By: (Saurabh Sarkar, Prateek Malhotra, Virender Guman) Department of Computer Science & Engineering G.L.Bajaj Institute of Technology & Mgmt. Greater Noida Uttar Pradesh Technical University Lucknow (U. P.) India A Novel Approach for Protein Structure Prediction January 1, 2010 CERTIFICATE This is to certify that the project report entitled “A Novel Approach for Protein Structure Prediction” submitted by by Saurabh Sarkar, Prateek Malhortra, Virender Guman in the Department of Computer Science & Engineering, G.L.Bajaj Institute of Technology and Management, Greater Noida for the award of Bachelor of Technology is a record of the bona-fide work carried out by them under my supervision. Details of the student(s) Certified by: Mr. Saurabh Sarkar (0619210099) Prof. K.S. Mehta HOD (CSE Department) Mr. Prateek Malhotra (0619210083) Mr. Virender Guman (0619210118) Department of the Computer Science & Engineering G.L.B.I.T.M. Greater Noida Page I A Novel Approach for Protein Structure Prediction January 1, 2010 ACKNOWLEDGEMENT At the very outset, we are highly indebted to G.L. Bajaj Instt. Of Tech. & Mgmt., Gr. -
13881 Hon. Gregg Harper Hon. Lynn C. Woolsey Hon
June 3, 2009 EXTENSIONS OF REMARKS, Vol. 155, Pt. 10 13881 In 1973, Ephraim Katzir answered Prime President Al Gore. Despite some initial skep- TRIBUTE TO MR. DAVE SALLENGS Minster Golda Meir’s call to serve as President ticism about a surgeon writing on other topics, of Israel. During the first year of his tenure, his books wove connections between every- HON. HAROLD ROGERS Israel was attacked by her Egyptian and Syr- thing from art and physics to human evolution OF KENTUCKY ian neighbors in the Yom Kippur War. Just in a highly creative and accessible style. IN THE HOUSE OF REPRESENTATIVES four years later, President Katzir and Prime Wednesday, June 3, 2009 Minister Menachem Begin welcomed Egyptian Art & Physics (1990) was hailed as a vision- President Anwar El Sadat to Jerusalem, mak- ary exploration of the work of scientists and Mr. ROGERS of Kentucky. Madam Speaker, ing Sadat the first Arab leader to visit the Jew- artists over the centuries. The Alphabet vs. the I rise today to pay tribute to Dave Sallengs, a ish capital. This visit, combined with President Goddess (1998) further enhanced his reputa- Kentuckian whose efforts to fight the scourge Katzir’s dedication to peace and human tion as an insightful and poetic storyteller while of drug addiction throughout Kentucky have made huge strides towards stopping this hor- progress, led to the Camp David Accords a Sex, Time and Power: How Women’s Sexu- rific epidemic. His extensive knowledge of year later and an easing in the previously con- ality Shaped Human Evolution (2003) offers scheduled prescription drug trends has im- tentious Israeli-Egyptian relations. -
Lady Asenath Sol Liptzin
LADY ASENATH SOL LIPTZIN THE HAND ON THE DOOR CHAIM ABRAMOWITZ ABRAHAM - SOME PSYCHOLOGICAL INSIGHTS MAX PUSIN ADAM'S RIB ELLIOT B. GERTEL TORAH DIALOGUES HAROLD D. HALPFRN THE WESTERN WALL BEN-ZION LURJ A HAMMURABI AND BIBLICAL LAWS MIRIAM Y. SHRAGER Voi.VD Winter IJ71-9 11'1~ 11'1 DOR le DOR Published by the WORLD JEWISH BIBLE SOCIETY In cooperation with the Department of Education and Culture of the World Zionist Organization and tbe World Jewish Congress, Cultural Department Honorary President: Professor EPHRAIM KATZIR Chairman: OR. HAIM GEVARYAHU Vice Chairman: DR. Louts KATZOPP Treasurer: BEN ZION LURIA Chairman, World Executive, Beth Hatenakb: CHAIM FINKELSTEIN Chairman, World Council, Beth Hatenakh: DR. I!RAEL GOLDSTEIN Chairman, Cultural Department, World Jewish Congress: ITZHAK HARKAVI Chairman for North America: OR. AzRIEL EISENBERG, New York City Chairman for Europe: HERMANN WOHLMANN, Zurich Editor: LOUIS KATZOFF Associate Editor: SHIMON BAKON Assistant Editor: CHAIM ABRAMOWITZ EDITORIAL BOARD PHILIP GOODMAN RICHARD HIRSCH S. GERSHON LEVI PAUL GOULD WOLFE KELMAN SoL LIPTZIN HAROLD D. HALPERN S. JOSHUA KOHN ABRAHAM RUDERMAN JOSEPH HALPERN LEON A. KRONITZ GABRIEL SIVAN MORDECAI SOCHEN Dor le-Dor is published by the World Jewish Bible Society for the English reading public and is directed primarily to interested Jewish laymen who wish to deepen their understanding and appreciation of their heritage through Bible study. WORLD JEWISH BIBLE SOCIETY, 18 Abarbanel St., JERUSALEM AN AFFILIATE OF THE DEPARTMENT OF EDUCATION AND CULTURE IN THE DIASPORA OP THE WORLD ZIONIST ORGANIZATION LADY ASENATH BY SOL LIPTZIN Asenath is mentioned only three times in the Bible. -
Israel and Chemical/Biological Weapons: History, Deterrence, and Arms Control
AVNER COHEN Israel and Chemical/Biological Weapons: History, Deterrence, and Arms Control AVNER COHEN1 Dr. Avner Cohen is Senior Fellow at the Center for International and Security Studies at Maryland, as well as the Program on Security and Disarmament, at the University of Maryland. He is the author of Israel and the Bomb (New York Columbia University Press, 1998). n April 1948, David Ben-Gurion, Israel’s founding Klingberg espionage case, as well as the 1991 Gulf War father and first prime minister, wrote a letter to Ehud and the subsequent revelations about Iraq’s chemical and IAvriel, one of the Jewish Agency’s operatives in Eu- biological programs, have aroused public curiosity and rope, ordering him to seek out and recruit East European speculation regarding Israel’s capabilities in the CBW field. Jewish scientists who could “either increase the capacity Yet details about these programs—their history, strategic to kill masses or to cure masses; both are important.”2 rationale, and technical capabilities—remain shrouded in One of the scientists Avriel recruited was a 30-year old secrecy. epidemiologist and colonel in the Red Army named A comparison with Israel’s nuclear weapons (NW) pro- Avraham Marcus Klingberg. In time, Klingberg became gram highlights this point. Although Israel has not acknowl- one of Israel’s leading scientists in the area of chemical edged possessing NW and has declared that it “will not and biological weapons (CBW). He was among the found- be the first to introduce nuclear weapons to the Middle ing members and, subsequently, the deputy director of East,” the existence of the Israeli bomb has been the the Israel Institute of Biological Research (IIBR) in Ness world’s worst kept secret since about 1970.4 That is not Ziona, a dozen miles southeast of Tel Aviv. -
Structural Biology Wikipedia, the Free Encyclopedia Structural Biology from Wikipedia, the Free Encyclopedia
28/9/2015 Structural biology Wikipedia, the free encyclopedia Structural biology From Wikipedia, the free encyclopedia Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules, especially proteins and nucleic acids, how they acquire the structures they have, and how alterations in their structures affect their function. This subject is of great interest to biologists because macromolecules carry out most of the functions of cells, and because it is only by coiling into specific threedimensional shapes that they are able to perform these functions. This architecture, the "tertiary structure" of molecules, depends in a complicated way on the molecules' basic composition, or "primary structures." Biomolecules are too small to see in detail even with the most advanced light microscopes. The methods that structural biologists use to determine their structures generally involve measurements on vast numbers of identical molecules at the same time. These methods include: Mass spectrometry Macromolecular crystallography Proteolysis Nuclear magnetic resonance spectroscopy of proteins (NMR) Hemoglobin, the oxygen transporting Electron paramagnetic resonance (EPR) protein found in red blood cells Cryoelectron microscopy (cryoEM) Multiangle light scattering Small angle scattering Ultra fast laser spectroscopy Dual Polarisation Interferometry and circular dichroism Most often researchers use them to study the "native states" of macromolecules. But variations on these methods are also used to watch nascent or denatured molecules assume or reassume their native states. See protein folding. A third approach that structural biologists take to understanding structure is bioinformatics to look for patterns among the diverse sequences that give rise to particular shapes.