Encountering the Organization
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Basso Et Al-2018-New Phytologi
Facing global change Veronica Basso, Maira de Freitas Pereira, François Maillard, Julieta Mallerman, Lauralie Mangeot-Peter, Feng Zhang, Clémence Bonnot To cite this version: Veronica Basso, Maira de Freitas Pereira, François Maillard, Julieta Mallerman, Lauralie Mangeot- Peter, et al.. Facing global change: The millennium challenge for plant scientists. New Phytologist, Wiley, 2018, 220 (1), pp.25-29. 10.1111/nph.15376. hal-01890694 HAL Id: hal-01890694 https://hal.archives-ouvertes.fr/hal-01890694 Submitted on 8 Oct 2018 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution| 4.0 International License Forum Meetings National Laboratory, TN, USA) highlighted the critical topics Facing global change: the and knowledge gaps the scientific community needs to fill in order to harness plant sciences to solve these societal issues. This event, millennium challenge for plant held in Nancy, France on 11–13 April 2018, hosted researchers scientists from 70 universities, research institutes and companies represent- ing 29 countries in the fields of Developmental biology, Evolu- 41st New Phytologist Symposium ‘Plant sciences tionary biology, Ecology, Plant–microorganism interactions, Physiology and Genetic engineering (Fig. 1). -
Autophagic Pathways in Health and Disease: Mitophagy and Neurodegeneration Nektarios Tavernarakis Institute of Molecular Biology
Autophagic pathways in health and disease: Mitophagy and neurodegeneration Nektarios Tavernarakis Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas Medical School, University of Crete, Heraklion, Crete, Greece Mitochondria, the main energy hub of the cell, are highly dynamic organelles, playing essential roles in fundamental cellular processes. Mitochondrial function impinges on several signalling pathways modulating cellular metabolism, cell survival and healthspan. Maintenance of mitochondrial function and energy homeostasis requires both generation of newly synthesized and elimination of dysfunctional mitochondria. Impaired mitochondrial function and excessive mitochondrial content are major characteristics of ageing and several human pathophysiological conditions, highlighting the pivotal role of the coordination between mitochondrial biogenesis and mitophagy. However, the cellular and molecular underpinnings of mitochondrial mass homeostasis remain obscure. We found that DCT-1, the Caenorhabditis elegans homolog of mammalian BNIP3 and BNIP3L/NIX, is a key mediator of mitophagy promoting longevity under stress. DCT-1 acts downstream of the PINK-1-PDR-1/Parkin pathway and is ubiquitinated upon mitophagy-inducing conditions to mediate the removal of damaged mitochondria. Accumulation of damaged mitochondria triggers SKN-1 activation, which initiates a bipartite retrograde signaling pathway stimulating the coordinated induction of both mitochondrial biogenesis and mitophagy genes. Taken together, our results unravel a homeostatic feedback loop that allows cells to adjust their mitochondrial population in response to environmental and intracellular cues. Age-dependent decline of mitophagy both inhibits removal of dysfunctional or superfluous mitochondria and impairs mitochondrial biogenesis resulting in progressive mitochondrial accretion and consequently, deterioration of cell function. . -
Phylogenomics Provides Robust Support for a Two-Domains Tree of Life
ARTICLES https://doi.org/10.1038/s41559-019-1040-x Phylogenomics provides robust support for a two-domains tree of life Tom A. Williams! !1*, Cymon J. Cox! !2, Peter G. Foster3, Gergely J. Szöllősi4,5,6 and T. Martin Embley7* Hypotheses about the origin of eukaryotic cells are classically framed within the context of a universal ‘tree of life’ based on conserved core genes. Vigorous ongoing debate about eukaryote origins is based on assertions that the topology of the tree of life depends on the taxa included and the choice and quality of genomic data analysed. Here we have reanalysed the evidence underpinning those claims and apply more data to the question by using supertree and coalescent methods to interrogate >3,000 gene families in archaea and eukaryotes. We find that eukaryotes consistently originate from within the archaea in a two-domains tree when due consideration is given to the fit between model and data. Our analyses support a close relation- ship between eukaryotes and Asgard archaea and identify the Heimdallarchaeota as the current best candidate for the closest archaeal relatives of the eukaryotic nuclear lineage. urrent hypotheses about eukaryotic origins generally pro- Indeed, it has previously been suggested that it is the 3D tree, rather pose at least two partners in that process: a bacterial endo- than the 2D tree, that is an artefact of long-branch attraction5,9–11, symbiont that became the mitochondrion and a host cell for both because analyses under better-fitting models have recovered C 1–4 that endosymbiosis . The identity of the host has been informed a 2D tree but also because the 3D topology is one in which the two by analyses of conserved genes for the transcription and transla- longest branches in the tree of life—the stems leading to bacteria and tion machinery that are considered essential for cellular life5. -
Female Fellows of the Royal Society
Female Fellows of the Royal Society Professor Jan Anderson FRS [1996] Professor Ruth Lynden-Bell FRS [2006] Professor Judith Armitage FRS [2013] Dr Mary Lyon FRS [1973] Professor Frances Ashcroft FMedSci FRS [1999] Professor Georgina Mace CBE FRS [2002] Professor Gillian Bates FMedSci FRS [2007] Professor Trudy Mackay FRS [2006] Professor Jean Beggs CBE FRS [1998] Professor Enid MacRobbie FRS [1991] Dame Jocelyn Bell Burnell DBE FRS [2003] Dr Philippa Marrack FMedSci FRS [1997] Dame Valerie Beral DBE FMedSci FRS [2006] Professor Dusa McDuff FRS [1994] Dr Mariann Bienz FMedSci FRS [2003] Professor Angela McLean FRS [2009] Professor Elizabeth Blackburn AC FRS [1992] Professor Anne Mills FMedSci FRS [2013] Professor Andrea Brand FMedSci FRS [2010] Professor Brenda Milner CC FRS [1979] Professor Eleanor Burbidge FRS [1964] Dr Anne O'Garra FMedSci FRS [2008] Professor Eleanor Campbell FRS [2010] Dame Bridget Ogilvie AC DBE FMedSci FRS [2003] Professor Doreen Cantrell FMedSci FRS [2011] Baroness Onora O'Neill * CBE FBA FMedSci FRS [2007] Professor Lorna Casselton CBE FRS [1999] Dame Linda Partridge DBE FMedSci FRS [1996] Professor Deborah Charlesworth FRS [2005] Dr Barbara Pearse FRS [1988] Professor Jennifer Clack FRS [2009] Professor Fiona Powrie FRS [2011] Professor Nicola Clayton FRS [2010] Professor Susan Rees FRS [2002] Professor Suzanne Cory AC FRS [1992] Professor Daniela Rhodes FRS [2007] Dame Kay Davies DBE FMedSci FRS [2003] Professor Elizabeth Robertson FRS [2003] Professor Caroline Dean OBE FRS [2004] Dame Carol Robinson DBE FMedSci -
Driving Diffusion of Scientific Innovation
Driving Diffusion of Scientific Innovation - The Role of Institutional Entrepreneurship and Open Science in Synthetic Biology Vom Promotionsausschuss der Technischen Universit¨at Hamburg-Harburg zur Erlangung des akademischen Grades Doktor der Wirtschafts- und Sozialwissenschaften (Dr. rer. pol.) genehmigte Dissertation von Giulio Barth aus M¨unster 2018 Advisors: Prof. Dr. C. Ihl, Prof. Dr. M. G. M¨ohrle Institute of Entrepreneurship, TUHH i Gutachter: Prof. Dr. C. Ihl Prof. Dr. M. G. Mohrle¨ Vorsitz: Prof. Dr. C. Luthje¨ Tag der mundlichen¨ Prufung:¨ 14. September 2018 ”Our victory: inevitable; our timing: uncertain.” (Drew Endy, Assistant Professor Stanford University) i Abstract Scientific innovations need to widely diffuse to fully exploit their potential. Prior research investigated levers on the diffusion of scientific innovation with particular interest on institutions, e.g., settings of property rights. As institutional theory lacks in explaining emergence and shaping of institu- tions, the institutional entrepreneur approach faces these limitations. Key actors combine logics from multiple fields and convince their social context of their ideas to legitimate the creation of new institutions and shape an emerging field. This thesis validates theories on institutional entrepreneurs and investigates the end-to process from diffusing a logic to the impact of an established insti- tution on scientific innovations in context of the emerging synthetic biology. The field is expected to introduce the 5th revolution and characterized by the central logic of making biology an engineering discipline. In chapter 4 theories on institutional entrepreneurs driving diffusion of in- stitutional logics to shape an emerging field are validated. To measure the social influence mechanisms, the heterogeneous diffusion model is adapted to the institutional logic. -
Development of a Genetic Multicolor Cell Labeling Approach for Neural
Development of a genetic multicolor cell labeling approach for neural circuit analysis in Drosophila Dafni Hadjieconomou January 2013 Division of Molecular Neurobiology MRC National Institute for Medical Research The Ridgeway Mill Hill, London NW7 1AA U.K. Department of Cell and Developmental Biology University College London A thesis submitted to the University College London for the degree of Doctor of Philosophy Declaration of authenticity This work has been completed in the laboratory of Iris Salecker, in the Division of Molecular Neurobiology at the MRC National Institute for Medical Research. I, Dafni Hadjieconomou, declare that the work presented in this thesis is the result of my own independent work. Any collaborative work or data provided by others have been indicated at respective chapters. Chapters 3 and 5 include data generated and kindly provided by Shay Rotkopf and Iris Salecker as indicated. 2 Acknowledgements I would like to express my utmost gratitude to my supervisor, Iris Salecker, for her valuable guidance and support throughout the entire course of this PhD. Working with you taught me to work with determination and channel my enthusiasm in a productive manner. Thank you for sharing your passion for science and for introducing me to the colourful world of Drosophilists. Finally, I must particularly express my appreciation for you being very understanding when times were difficult, and for your trust in my successful achieving. Many thanks to my thesis committee, Alex Gould, James Briscoe and Vassilis Pachnis for their quidance during this the course of this PhD. I am greatly thankful to all my colleagues and friends in the lab. -
Genetics Society News
July 2008 . ISSUE 59 GENETICS SOCIETY NEWS www.genetics.org.uk IN THIS ISSUE Genetics Society News is edited by Steve Russell. Items for future issues should be sent to Steve Russell, preferably by email to • Genetics Society Epigenetics Meeting [email protected], or hard copy to Department of Genetics, • Genetics Society Sponsored Meetings University of Cambridge, Downing Street, Cambridge CB2 3EH. The Newsletter is published twice a year, with copy dates of 1st June and • Travel, Fieldwork and Studentship Reports 26th November. • John Evans: an Appreciation Cocoons of the parasitoid wasp Cotesia vestalis on cabbage leaf in Taiwan. From the • Twelve Galton Lectures fieldwork report by Jetske G. de Boer on page 36. • My Favourite Paper A WORD FROM THE EDITOR A word from the editor ow soon until the $1000 based on the results of tests we genome is actually with barely understand! Here in the Hus and individual UK there is currently a sequencing is widespread? The moratorium, adhered to by publication of increasing most insurers, on the use of numbers of individual human genetic testing information for genome sequences suggests assessing life insurance that we should start to consider applications. It is important some of the implications that this remains in place and associated with the availability its effectiveness is reviewed of personal genetic well before the current information. In this issue we moratorium expires in 2011. present two articles reflecting The Human Genetics on his issue: a report from a Commission Genetics Society sponsored (http://www.hgc.gov.uk) meeting recently held in monitor issues relating to Cambridge organised by The genetic discrimination in the Triple Helix, an international UK and are a point of contact undergraduate organisation, as for those with any concerns in the Millennium Technology Prize. -
Mechanisms Directing Receptor-Specific Gene Regulation
Mechanisms Directing Receptor-Specific Gene Regulation by the Androgen and Glucocorticoid Receptor Inaugural-Dissertation to obtain the academic degree Doctor rerum naturalium (Dr. rer. nat.) submitted to the Department of Biology, Chemistry, Pharmacy of Freie Universität Berlin by Marina Kulik • 2021 The dissertation was prepared under the supervision of Dr. Sebastiaan H. Meijsing at the Max Planck Institute for Molecular Genetics in Berlin from September 2015 to February 2021. 1st Reviewer: Dr. Sebastiaan Meijsing 2nd Reviewer: Prof. Dr. Markus Wahl Date of defense: 21.05.2021 1 Selbstständigkeitserklärung Hiermit bestätige ich, dass ich die vorliegende Arbeit selbstständig und unter Zuhilfenahme der angegebenen Literatur erstellt habe. Acknowledgments First of all, I would like to express my gratitude to my supervisor Sebastiaan Meijsing for his support and guidance during my PhD. I would like to thank Martin Vingron for the opportunity to be part of his research group and for the great collaborations. Especially, I would like to thank Stefan Haas for introducing me to the world of RNA-seq and Gözde Kibar, who contributed with her bioinformatical analyses to this work. I would like to thank Sarah Kinkley for her support and for giving me the opportunity to finish my PhD in her group. I wish to thank Stefan Prekovic, Isabel Mayayo-Peralta and Wilbert Zwart from the NKI in Amsterdam for sharing their expertise in “nuclear signaling” and the great collaboration. I am particularly grateful to Melissa Bothe, her computational analyses and support in the lab contributed a lot to this work. My special gratitude goes to Laura Glaser for her continuous advice and for freezing my cells in the evening countless times. -
Plant Development Series Editor Paul M
VOLUME NINETY ONE CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY Plant Development Series Editor Paul M. Wassarman Department of Developmental and Regenerative Biology Mount Sinai School of Medicine New York, NY 10029-6574 USA Olivier Pourquié Institut de Génétique et de Biologie Cellulaire et Moléculaire (IGBMC) Inserm U964, CNRS (UMR 7104) Université de Strasbourg Illkirch France Editorial Board Blanche Capel Duke University Medical Center Durham, NC, USA B. Denis Duboule Department of Zoology and Animal Biology NCCR ‘Frontiers in Genetics’ Geneva, Switzerland Anne Ephrussi European Molecular Biology Laboratory Heidelberg, Germany Janet Heasman Cincinnati Children’s Hospital Medical Center Department of Pediatrics Cincinnati, OH, USA Julian Lewis Vertebrate Development Laboratory Cancer Research UK London Research Institute London WC2A 3PX, UK Yoshiki Sasai Director of the Neurogenesis and Organogenesis Group RIKEN Center for Developmental Biology Chuo, Japan Philippe Soriano Department of Developmental and Regenerative Biology Mount Sinai Medical School New York, USA Cliff Tabin Harvard Medical School Department of Genetics Boston, MA, USA Founding Editors A. A. Moscona Alberto Monroy VOLUME NINETY ONE CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY Plant Development Edited by MARJA C. P. TIMMERMANS Cold Spring Harbor Laboratory Cold Spring Harbor New York, USA AMSTERDAM • BOSTON • HEIDELBERG • LONDON NEW YORK • OXFORD • PARIS • SAN DIEGO SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO Academic Press is an imprint of Elsevier Academic Press is an imprint of Elsevier 525 B Street, Suite 1900, San Diego, CA 92101-4495, USA 30 Corporate Drive, Suite 400, Burlington, MA 01803, USA 32, Jamestown Road, London NW1 7BY, UK Linacre House, Jordan Hill, Oxford OX2 8DP, UK First edition 2010 Copyright Ó 2010 Elsevier Inc. -
Born in Geneva in 1955) Is a Swiss-French Biologist
C.V. Prof Denis Duboule Denis Duboule ForMemRS (born in Geneva in 1955) is a Swiss-French biologist. He earned his PhD in Biology in 1984 and is currently Professor of Developmental Genetics and Genomics at the EPFL and at the department of Genetics and Evolution of the University of Geneva. Since 2001, he is also the Director of the Swiss National Research Center ‘Frontiers in Genetics’. He has notably worked on Hox genes, a group of genes involved in the formation of the body plan and of the limbs. Denis Duboule obtained a PhD from the University of Geneva in 1984. After questioning Karl Illmensee's claims of having cloned a mouse, Duboule departed to work as a postdoc and then a group leader at the University of Strasbourg, with Pierre Chambon. In 1988, he became a group leader at the European Molecular Biology Laboratory in Heidelberg, Germany. In 1992, he obtained a tenure at the Geneva University. From 1997, he has headed the Department of Genetics and Evolution (formerly Zoology and Animal Biology) Since 2001, he has also chaired the NCCR Frontiers in Genetics and, since 2006, he is a full professor at the EPFL. Denis Duboule has a longstanding interest in the function and regulation of Hox genes, a family of genes responsible for the organization and evolution of animal body plans. These genes have been a paradigm to understand embryonic patterning, in developmental, evolutionary and pathological contexts. Denis Duboule's contributions are thus in the field of vertebrate developmental genetics with some interface with medical genetics and evolutionary biology. -
From Telomeres to Empathy Highlights from the EMBO Meeting 2010 by CRISTINA JIMÉNEZ
AUTUMN 2010 encounters Newsletter of the European Molecular Biology Organization From telomeres to empathy Highlights from The EMBO Meeting 2010 BY CRISTINA JIMÉNEZ ◗ In the early 1980s, after a meeting at the Gordon Research Conference, Elizabeth Blackburn and Jack Szostak discovered that telo meres include a specifi c DNA sequence. 29 years on, the fortuitous encounter resulted in a Nobel Prize for discovering the structure Elizabeth Frans de Waal Blackburn of molecular caps called telomeres and for working out how they protect chromosomes from degradation. This is only one fi brillation, a condition in Richard example of how necessary meetings can be for the advancement of sci- which there is uncoordinated Losick ence. They provide a perfect setting for junior researchers to approach contraction of the cardiac prospective supervisors – and vice versa. They can lead to new part- muscle of the ventricles in the nerships between research groups working in similar fi elds. And they heart, making them quiver also inspire open discussion and collaboration between institutions. rather than contract properly. The EMBO Meeting, held in September in Barcelona, gathered more Haïssaguerre explained how than 1,300 researchers from a broad scope of disciplines, extending he is currently having great from synthetic, developmental and evolutionary biologists to plant success in curing hundreds of scientists and neuroscientists. “Postdocs and PhD students are the patients every year from this main benefi ciaries of these meetings,” pointed out Luis Serrano, who sort of arrhythmia. Austin co-organized the meeting with Denis Duboule. Smith, the other prize winner, | Barcelona © Christine Panagiotidis The meeting kicked off on Saturday 4 September with Richard Losick gave a lecture on stem cells and the Design principles of pluripotency. -
VII EUROPEAN CONGRESS of PROTISTOLOGY in Partnership with the INTERNATIONAL SOCIETY of PROTISTOLOGISTS (VII ECOP - ISOP Joint Meeting)
See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/283484592 FINAL PROGRAMME AND ABSTRACTS BOOK - VII EUROPEAN CONGRESS OF PROTISTOLOGY in partnership with THE INTERNATIONAL SOCIETY OF PROTISTOLOGISTS (VII ECOP - ISOP Joint Meeting) Conference Paper · September 2015 CITATIONS READS 0 620 1 author: Aurelio Serrano Institute of Plant Biochemistry and Photosynthesis, Joint Center CSIC-Univ. of Seville, Spain 157 PUBLICATIONS 1,824 CITATIONS SEE PROFILE Some of the authors of this publication are also working on these related projects: Use Tetrahymena as a model stress study View project Characterization of true-branching cyanobacteria from geothermal sites and hot springs of Costa Rica View project All content following this page was uploaded by Aurelio Serrano on 04 November 2015. The user has requested enhancement of the downloaded file. VII ECOP - ISOP Joint Meeting / 1 Content VII ECOP - ISOP Joint Meeting ORGANIZING COMMITTEES / 3 WELCOME ADDRESS / 4 CONGRESS USEFUL / 5 INFORMATION SOCIAL PROGRAMME / 12 CITY OF SEVILLE / 14 PROGRAMME OVERVIEW / 18 CONGRESS PROGRAMME / 19 Opening Ceremony / 19 Plenary Lectures / 19 Symposia and Workshops / 20 Special Sessions - Oral Presentations / 35 by PhD Students and Young Postdocts General Oral Sessions / 37 Poster Sessions / 42 ABSTRACTS / 57 Plenary Lectures / 57 Oral Presentations / 66 Posters / 231 AUTHOR INDEX / 423 ACKNOWLEDGMENTS-CREDITS / 429 President of the Organizing Committee Secretary of the Organizing Committee Dr. Aurelio Serrano