JOURNAL of VIROLOGY VOLUME 45 * NUMBER 3 * MARCH 1983 Edward M

JOURNAL OF VIROLOGY VOLUME 45 * NUMBER 3 * MARCH 1983 Edward M. Scolnick, Editor-in-Chief (1987) Harold S. Ginsberg, Editor (1984) Merck Sharp & Dohme Research Laboratories Columbia University West Point, Pa. New York, N.Y. Dwight L. Anderson, Editor (1983) David T. Denhardt, Editor (1987) Robert M. Krug, Editor (1987) School ofDentistry, University of Western Ontario Sloan-Kettering Institute University ofMinnesota, London, Ontario, Canada New York, N.Y. Minneapolis

EDITORIAL BOARD Davd Baltimore (1984) Alice S. Huang (1984) Gordon M. Ringold (1984) Amiya K. Banerjee (1985) Tony Hunter (1983) Harriet Robinson (1985) Andrew Becker (1985) Masayori Inouye (1985) William S. Robinson (1983) Tamar Ben-Porat (1984) Robert Kamen (1985) Bernard Roizman (1985) Kenneth I. Berns (1985) Thomas J. Kelly, Jr. (1985) Roland R. Rueckert (1985) David Botstein (1985) George Khoury (1984) Norman P. Salzman (1984) Dennis T. Brown (1984) Elliott Kieff (1984) Joseph Sambrook (1985) Ahmad I. Bukhari (1984) Jonathan A. King (1984) Priscilia A. Schaffer (1984) Barrie J. Carter (1984) Daniel Kolakofsky (1983) Sondra Schlesinger (1983) Purneil Choppin (1983) Robert Lamb (1985) June R. Scott (1983) John M. Coffin (1983) Robert A. Lazzarini (1984) Bart Sefton (1985) Geoffrey M. Cooper (1984) Myron Levine (1985) Phillip A. Sharp (1985) Walter Doerfler (1983) Douglas R. Lowy (1983) Thomas E. Shenk (1984) Harrison Echols (1984) Robert Martin (1984) Charles J. Sherr (1984) Elvera Ehrenfeld (1983) George Milier (1984) Saul J. Silverstein (1985) Robert N. Eisenman (1985) Lois K. MiUler (1985) Lee D. Simon (1984) Suzanne U. Emerson (1983) Robert C. Milier (1983) Ann Skalka (1985) S. Jane Flint (1984) Peter Model (1983) Patricia G. Spear (1984) Yasuhiro Furuichi (1985) Bernard Moss (1983) Mark F. Stinski (1983) Costa Georgopolous (1983) Nancy G. Nossal (1984) F. William Studier (1984) Larry M. Gold (1985) J. Thomas Parsons (1983) Lawrence S. Sturman (1985) Peter Gruss (1985) Ulf G. Petterson (1983) Jesse Summers (1985) Hidesaburo Hanafusa (1983) Lennart Philipson (1984) William Summers (1985) William S. Hayward (1984) Lewis I. Pizer (1984) John M. Taylor (1984) John J. Holland (1984) Craig R. Pringle (1983) Howard M. Temin (1985) Ian H. Holmes (1983) Fred Rapp (1984) George F. Vande Woude (1983) Robert W. Honess (1983) Dan S. Ray (1983) Edward K. Wagner (1983) Nancy Hopkins (1983) M. E. Reichmann (1985) Eckard Wimmer (1985) Peter M. Howley (1984) Bernard E. Reilly (1983) Charles Hamish Young (1983)

Helen R. Whiteley, Chairman, Publications Board Walter G. Peter III, Director, Publications Linda M. Illig, Managing Editor, Journals Susan Birch, Production Editor

The Journal of Virology (ISSN 0022-538X), a publication of the American Society for Microbiology, 1913 I St., NW, Washington, DC 20006, is devoted to the dissemination of fundamental knowledge concerning viruses of bacteria, plants, and animals. Investigators are invited to submit reports of original research in all areas of basic virology, including biochemistry, biophysics, genetics, immunology, morphology, and physiology. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Publications Office. The Journal is issued monthly, four volumes per year. The nonmember subscription price is $225 per year; single copies are $20. The member subscription price is $37 (foreign, $44 [surface rate]) per year; single copies are $7.00. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publications Office, 1913 I St., NW, Washington, DC 20006 (area 202 833-9680). Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing because of failure to report an address change or for issues "missing from files" will not be allowed. Second-class postage paid at Washington, DC 20006, and at additional mailing offices. POSTMASTER: Send address changes to Journal of Virology, ASM, 1913 I St., NW, Washington, DC 20006. Made in the U.S.A. Copyright C 1983, American Society for Microbiology. Ei *1f:#J^X I'JkX All Rights Reserved. The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the article may be made for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per-copy fee through the Copyright Clearance Center, 21 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Author Index Akashi, Hiroomi, 1155 Hillyard, Robert L., 925 Paskind, Michael, 1195 Anderson, Soni J., 1004 Holmes, Ian H., 1143 Perbal, Bernard, 925 Arlinghaus, R. B., 1183 Hunter, Tony, 1177 Preston, Valerie G., 1056 Arlinghaus, Ralph B., 1200 Prives, Carol, 901 Ikeda, Hideo, 971 Baltimore, David, 1195 Imatani, Yoshiko, 1074 Rapp, Ulf R., 914 Baluda, Marcel A., 925 Ishii, Ai, 1167 Rassart, Eric, 1159 Belsham, Graham J., 1098 Rein, Alan, 995 Benjamin, David C., 1190 Reuter, Monika, 1147 Bestwick, Richard, 1217 Jolicoeur, Paul, 1159 Reynolds, Fred H., Jr., 914 Bishop, David H. L., 1155 Risser, Rex, 950 Bloom, Marshall E., 977 Rixon, Frazer J., 1056 Borde, Janine, 901 Kabat, David, 1217 Rodrigues-Molto, Maria-Pilar, 1048 Breschkin, Alan M., 1143 Karshin, William L., 1200 Roth, M. G., 1065 Brown, Dennis T., 1083, 1090 Kashmiri, S. V. S., 1172 Rowe, Wallace P., 956 Bryant, Debra, 1211 Khoury, George, 1004 Ruta, Martin, 1217 Kiessling, Ann, 1217 Kloetzer, W. S., 1183 Chaudry, Furzana, 1098 Kopchick, John J., 1200 Saito, Izumu, 1074 Chepelinsky, Ana B., 992 Kotler, Moshe, 1150 Sarma, Padman S., 956 Chiu, Nancy H., 992 Kruger, Detlev H., 1147 Schultz, Alan, 995 Cline, Janice M., 925 Scolnick, Edward, 1217 Coates, Jonathan A. V., 1056 Sen, Ganes C., 1017 Cochran, Mark A., %1 Lasne, Claude, 901 Sharma, Opendra K., 1164 Compans, R. W., 1065 Latt, Samuel A., 1195 Sherr, Charles J., 1004 Conley, Anthony J., 1223 Lee, John C., 1037 Shimojo, Hiroto, 1074 Lin, Jung-Chung, 985 Shiroki, Kazuko, 1074 Linemeyer, David, 1217 Smirnov, Y. A., 1048 Dane, Richard W., 1207 Lorch, Yahli, 1150 Smith, Alan E., 1098 Demsey, Anthony, 1140 Lowy, Douglas, 1004 Smith, M. Carolyn, 985 DesGroseillers, Luc, 1159 Snitzer, Karen, 1223 Donehower, Lawrence A., 941 Sonza, Secondo, 1143 Mak, I., 1107 Spear, Patricia G., 1223 Mak, S., 1107 Srinivas, R. V., 1065 Edwards, Judy, 1083, 1090 Mann, Eric, 1083, 1090 Stanker, L. H., 1183 Ely, Constance M., 1190 Martin, Robert G., 992 Stanker, Larry H., 1200 Even, Jos, 1004 Maruyama, Kazuo, 1074 Stephenson, John R., 914 Matsumoto, Tadashi, 971 Stoltzfus, C. Martin, 1207 May, Evelyne, 901 Famadas, Mayra Teijelo, 1048 May, Pierre, 901 Faulkner, Peter, %1 Mayer, Leonard W., 977 Tabin, Clifford J., 1195 Faust, Charles, 1217 McCarley, Deborah J., 1190 Trousdale, Melvin D., 1037 Ferrer, Jorge F., 1172 McCubrey, James, 950 Fleurdelys, Barbara, 941 Mehdi, Rafia, 1172 Friedman, Robert M., 1140 Murphy, E. C., Jr., 1183 Velicer, Leland F., 1228 Friedmann, Adam, 1150 Fukui, Yasuhisa, 1074 Naso, Robert B., 1199 Walker, Donald H., Jr., 1118 Nazerian, Kevyan, 1228 Walker, Jean T., 1118 Galibert, Francis, 1004 Ng, Valerie L., 1200 Wang, Jean Y.-J., 1195 Gallick, G. E., 1183 Nicolaiew, Nathalie, 1159 Wang, Shaw-Shyan, 992 Garon, Claude F., 977 Watanabe, Susan M., 1028 Gauntt, Charles J., 1037 Weinberger, Michael, 1223 Glaubiger, Carol, 1228 Oda, Kin-ichiro, 1074 Witte, Owen N., 1028 Goff, Stephen P., 1195 Oroszlan, Stephen, 995 Goswami, Biswendu B., 1164 Yonehara, Shin, 1168 Pagano, Joseph S., 985 Yonehara-Takahashi, Minako, Hager, Gordon L., 941 Papkoff, Jackie, 1177 1168 Hampe, Annie, 1004 Paque, Ronald E., 1037 Hansen, Sigrid, 1147 Para, Michael F., 1223 Henderson, Louis, 995 Parsons, J. Thomas, 1190, 1211 Zannis-Hadjopoulos, Maria, 992 Herz, Ruth E., 1017 Parsons, Sarah J., 1190 Zezulak, Kathleen M., 1223 AUTHOR INDEX VOLUME 45

Aboud, Mordechai, 489 Chanda, Pranab K., 55 Friedman, Robert M., 1140 Adachi, Akio, 447 Chatis, Pamela A., 80 Friedmann, Adam, 496, 1150 Akashi, Hiroomi, 1155 Chatterjee, Nando K., 832 Friedrich, Roland, 1 Allen, Jerry L., 665 Chattopadhyay, Sisir K., 291 Frink, R. J., 634 Anderson, Carl W., 251 Chaudry, Furzana, 693, 1098 Fukui, Yasuhisa, 420, 1074 Anderson, Dwight L., 383 Cheetham, B. F., 192 Furcht, Leo, 859 Anderson, Soni J., 1004 Chen, Irvin S. Y., 104 Furlong, Deirdre, 397 Arlinghaus, R. B., 1183 Chepelinsky, Ana B., 992 Arlinghaus, Ralph B., 1200 Chiu, Nancy H., 992 Galibert, Francis, 466, 1004 Arnheiter, Heinz, 773 Chumakov, Ilya, 505 Gallick, G. E., 1183 Astrin, S., 868 Cline, Janice M., 925 Garon, Claude F., 977 Atherton, Sally S., 855 Coates, Jonathan A. V., 1056 Gauntt, Charles J., 1037 Cochran, Mark A., 961 Gilmer, Tona M., 462 Cohen, G., 634 Glaubiger, Carol, 1228 Bacchetti, Silvia, 514 Compans, R. W., 1065 Glickman, Rhona L., 18 Bajszar, Gyorgy, 62 Condra, Jon H., 773 Glorioso, Joseph, 672 Baltimore, David, 1195 Conley, Anthony J., 1223 Gluzman, Yakov, 91 Baluda, Marcel A., 925 Cross, Frederick R., 683 Gobet, Marcelle, 466 Baric, Ralph S., 200 Godowski, Paul J., 332 Barkan, Alice, 36 Goff, Stephen P., 1195 Batterson, William, 397 Dane, Richard W., 1207 Matthew 740 Bayley, Stanley T., 514 Danna, Kathleen J., 264 Gonda, A., Beaud, Georges, 452 Dannenberg, Richard, 813 Goswami, Biswendu B., 1164 Beigalke, Bonita, 133 Darnell, James E., Jr., 683 Gourlie, Brian, 600 Bell, John R., 708 Davis, Nancy L., 155 Gourlie, Brian B., 585 Bellett, A. J. D., 192 Deans, Robert, 864 Graessmann, Adolf, 375 Belsham, Graham J., 1098 Degener, Anna M., 889 Graham, Frank L., 514 Ben-Hamida, Fakher, 452 Demsey, Anthony, 1140 Graves, Michael C., 309 Benjamin, David C., 1190 DesGroseillers, L., 539, 565 Greiser-Wilke, Irene, 375 Bennett, J. Claude, 885 DesGroseillers, Luc, 1159 Grinnell, Brian W., 299 Berk, Arnold J., 594 Diala, Edward S., 482 Gunnell, Mark, 740 Berns, Kenneth I., 555 Diggelmann, Heidi, 148 Gupta, Kailash C., 659 Berthelot, Nicole, 715 Dixon, Richard A. F., 343 Bestwick, Richard, 1217 Donehower, Lawrence A., 941 Hager, Gordon L., 941 Bhown, Ajit, 885 Donoghue, Daniel J., 607 Hampe, Annie, 466, 1004 Birkenmeier, Edward, 740 Downey, James F., 514 Hanafusa, Hidesaburo, 782 Bishop, David H. L., 1155 Dunigan, David D., 618 Hansen, Sigrid, 1147 Bjornsti, Mary-Ann, 383 Duyk, G., 727 Harbers, Klaus, 505 Bleumink, Nancy, 140 Hartley, Janet W., 275 Bloom, Marshall E., 977 Hassan, Yehudith, 489 Bond, Martha W., 708 Earhart, Charles F., 700 Hauser, Hansjorg, 375 Bonner, Tom I., 740 Ebeling, Angelika, 715 Hayday, Adrian C., 693 Boone, Lawrence R., 484 Edwards, Judy, 1083, 1090 Hayden, Melody, 864 Borde, Janine, 901 Eisenberg, R., 634 Henderson, Louis, 995 Boschek, Bruce, 367 Ely, Constance M., 1190 Henning, Roland, 531 Braithwaite, A. W., 192 Erikson, R. L., 462 Herz, Ruth E., 1017 Bratt, Michael A., 18 Erwin, Christine, 792 Hilgers, Jo, 140 Breschkin, Alan M., 1143 Etkind, Polly R., 114 Hilkens, John, 140 Brewer, Gregory J., 226 Even, Jos, 466, 1004 Hill, Thomas M., 241 Broni, Barbara, 27 Hillyard, Robert L., 925 Brown, Arthur, 47 Hoffman, Robert M., 482 Brown, Dennis T., 792, 1083, 1090 Facchini, Jole, 889 Hoggan, M. David, 473 Bryant, Debra, 1211 Falvey, Eileen, 185 Holland, Christie A., 291 Buckler, Charles E., 473 Famadas, Mayra Teijelo, 1048 Holland, Thomas C., 672 Buijs, Femke, 140 Faras, Anthony, 859 Holloway, Brian P., 882 Bumke-Vogt, Christiane, 375 Faulkner, Peter, 961 Holmes, Ian H., 1143 Buonagurio, D., 547 Faust, Charles, 1217 Honigman, Alik, 456 Burns, Nancy, 859 Feldman, Ricardo A., 782 Hopkins, Nancy H., 275, 291 Ferrer, Jorge F., 1172 Howett, Mary K., 478 Fiers, Walter, 315, 442 Hunkapiller, Michael W., 708 Campbell, Elizabeth A., 439 Fleckenstein, Bernhard, 715 Hunsmann, Gerhard, 1 Carlin, Lisa J., 200 Fleurdelys, Barbara, 941 Hunt, Lawrence A., 233 Casjens, Sherwood, 864 Fransen, Lucie, 315, 442 Hunter, Eric, 885 Chambers, Thomas M., 55 Fried, Mike, 693 Hunter, Tony, 607, 1177 i ii AUTHOR INDEX J. VIROL. Ikeda, Hideo, 971 Lucas-Lenard, Jean M., 618 Padgett, Billie L., 299 Imatani, Yoshiko, 1074 Lundrigan, Michael D., 700 Pagano, Joseph S., 985 Ishii, Ai, 1167 Lung, Maria Li, 275, 291 Pagnotti, P., 889 Ishimoto, Akinori, 447 Lusby, Edward W., 555 Palese, P., 547 Lycan, Deborah E., 264 Panet, Amos, 456 Papkoff, Jackie, 1177 Jackson, Ethel, 864 Paque, Ronald E., 1037 Jackson, Richard J., 439 Mak, I., 1107 Para, Michael F., 1223 Jaenisch, Rudolf, 505 Mak, S., 1107 Paradiso, Peter R., 173 Jay, Gilbert, 428 Malavarca, R., 868 Parish, C. R., 192 Jenkins, Frank J., 478 Malik, N., 600 Parsons, J. Thomas, 1190, 1211 Jikuya, Hiroyuki, 73 Mann, Eric, 1083, 1090 Parsons, Sarah J., 1190 Johnson, S., 727 Marlin, Steven D., 672 Paskind, Michael, 1195 Johnson, S. P., 876 Martin, Malcolm A., 473 Patterson, Jean L., 882 Johnston, Robert E., 200 Martin, Robert G., 992 Patton, John T., 155 Jolicoeur, P., 539, 565 Maruyama, Kazuo, 408, 1074 Peeples, Mark E., 18 Jolicoeur, Paul, 1159 Masker, Warren E., 665 Pepinsky, Robert B., 648, 885 Mason, William S., 165 Perbal, Bernard, 925 Masuda, Miyuki, 408, 420 Perez-Bercoff, R., 889 Kabat, David, 1217 Matsumoto, Tadashi, 971 Person, Anne, 452 Kahn, S., 868 Matsunaga, Y., 627 Pigiet, V., 600 Karshin, William L., 1200 Matsuno, S., 627 Pigiet, Vincent P., 585 Kashmiri, S. V. S., 1172 May, Evelyne, 901 Poirot, Mary K., 206 Kato, Hiroyuki, 408 May, Pierre, 901 Preston, Valerie G., 1056 Keil, Gunther, 715 Mayer, Leonard W., 977 Prieto-Soto, Alis, 600 Kelly, Margaret, 291 McCarley, Deborah J., 1190 Prives, Carol, 901 Khoury, George, 428, 1004 McCubrey, James, 950 Kiessling, Ann, 1217 Mehdi, Rafia, 1172 Rapp, Fred, 478 Kiggans, J. O., 484 Mertz, Janet E., 36 Rapp, Ulf R., 740, 755, 914 Kimura-Kuroda, Junko, 124 Michel, James L., 524 Kingsbury, D. W., 659 Miwa, M., 600 Rappuoli, Rino, 524 W. Rassart, E., 539, 565 Kloetzer, S., 1183 Miyamura, Tatsuo, 73 Rassart, Eric, 1159 Knipe, David M., 332 Moelling, Karin, 375 Re, Gian G., 659 Koch, Werner, 1 Molnar-Kimber, Katherine L., 165 Reichmann, M. E., 206 Koh, Chong, 484 Montenarh, Mathias, 531 Reilly, Bernard E., 383 Kolakofsky, Daniel, 882 Morrison, Trudy G., 80 Rein, Alan, 995 Kopchick, John J., 1200 Mosig, Gisela, 813 Reuter, Monika, 1147 Kotler, Moshe, 1150 Moss, Bernard, 62 Reynolds, Fred H., Jr., 914 Kroezen, Vera, 140 Murphy, Andrew, 36 Rhode, Solon L., III, 173 Krug, Robert M., 27 Murphy, E. C., Jr., 1183 Susan Kruger, Detlev H., 1147 Murphy, John R., 524 Ridley, Porter, 800 547 Risser, Rex, 950 Krystal, M., Myer, Fred E., 484 Rixon, Frazer J., 1056 Kwiatkowski, Bartlomiej, 367 Rodrigues-Molto, Maria-Pilar, Naso, Robert B., 1199 1048 Lai, Ching-Juh, 434 Nayak, Debi P., 55 Roizman, Bernard, 397 Lancaster, John H., 700 Nazerian, Kevyan, 1228 Roth, M. G., 1065 Lasne, Claude, 901 Ng, Valerie L., 1200 Rowe, David T., 514 Latt, Samuel A., 1195 Nicolaiew, Nathalie, 1159 Rowe, Wallace P., 275, 473, 956 Lazzarini, Robert A., 766, 773 Nomura, Shigeko, 428 Ruta, Martin, 1217 Lee, Elsbeth J., 895 Nowak, Barbara, 715 Lee, John C., 1037 Sabourin, Dennis J., 343, 354 Lee, Kathryn J., 354 Sadler, John R., 241 Leis, J., 727, 876 O'Banion, M. Kerry, 206 Saito, Izumu, 408, 420, 1074 Lemay, G., 565 Obijeski, John F., 882 Sakai, Koji, 447 Levine, Kathryn L., 576 O'Callaghan, Dennis J., 855 Samsonoff, William A., 832 Levine, Myron, 672 Oda, Kin-ichiro, 1074 Sankar-Mistry, P., 565 Li, P., 192 Oda, Kinichiro, 408, 420 Sarkar, Nurul H., 114 Lin, Bor-Chian, 434 Oosterom-Dragon, Elizabeth A., Sarma, Padman S., 956 Lin, Jung-Chung, 985 251 Schaffer, Priscilla A., 343, 354 Linemeyer, David, 1217 Oroszlan, Stephen, 995 Schnieke, Angelika, 505 Linial, Maxine, 133 Osborne, Timothy F., 594 Schnitzlein, W. M., 206 Liou, Ruey-Shyan, 47 Otten, James A., 47 Scholl, D. R., 868 Longiaru, M., 727 Owen, Dianne, 148 Schultz, Alan, 995 Lorch, Yahli, 496, 1150 Scolnick, Edward, 1217 Lowy, Douglas, 1004 Sears, Johnna F., 473 Lowy, Douglas R., 291 Pachl, Carol, 133 Segawa, Kaoru, 872 VOL. 45, 1983 AUTHOR INDEX iii Sen, Ganes C., 1017 Stuhlmann, Heidi, 505 Walker, Duard L., 299 Serwer, Philip, 665 Sugano, Sumio, 408 Walker, Jean T., 1118 Sharma, Opendra K., 1164 Sugimura, T., 600 Wang, Eugenia, 782 Sharp, Janice A., 10 Summers, Jesse, 165 Wang, Jean Y.-J., 1195 Sheldrick, Peter, 715 Summers, Max D., 215 Wang, Shaw-Shyan, 992 Sherr, Charles J., 466, 1004 Summers, William C., 10 Wang, Tsei-Wei, 47 Shimojo, Hiroto, 408, 420, 1074 Watanabe, Susan M., 1028 Shiroki, Kazuko, 408, 420, 1074 Weinberger, Michael, 1223 Simizu, Bunsiti, 708 Tabin, Clifford J., 1195 Weir, Jerry P., 62 Sinden, Richard R., 241 Takemoto, Kenneth K., 872 Weis, John, 859 Skalka, A., 727 Taylor, John M., 165 Weller, Sandra K., 354 Skalka, A. M., 868 Temin, Howard M., 104 Wertz, Gail W., 155 Smirnov, Y. A., 1048 Tennant, Raymond W., 47, 484 Wickner, Reed B., 800 Smith, Alan E., 1098 Thiele, Horst, 367 Wilhelmsen, Kirk C., 104 Smith, Dennis, 859 Trousdale, Melvin D., 1037 Witte, Owen N., 1028 Smith, Gale E., 215 Tuchowski, Catherine, 832 Wittek, Riccardo, 62 Smith, M. Carolyn, 985 Wright, Stephen E., 233 Smulson, Mark, 600 Snitzer, Karen, 1223 Ulmanen, Ismo, 27 Soeda, Eiichi, 73 Sonza, Secondo, 1143 Yamamoto, Kiichi, 708 Spang, Anne E., 332 van der Zeijst, Ben, 140 Yang, D. M., 484 Spear, Patricia G., 1223 Van Doren, Kevin, 91 Yang, Funmei, 766 Sprague, Judy, 773 Van Roy, Frans, 315, 442 Yang, Wen K., 47, 484 Sreevalsan, Thazepadath, 895 Vanaman, T., 876 Yasui, Kotaro, 124 Srinivas, R. V., 1065 Veigl, M., 876 Yonehara, Shin, 1168 Srivastava, Arun, 555 Velicer, Leland F., 1228 Yonehara-Takahashi, Minako, Staczek, John, 855 Villemur, R., 539 1168 Stanker, L. H., 1183 Vlak, Just M., 215 Yoshiike, Kunito, 73 Stanker, Larry H., 1200 Vogt, Volker M., 648, 885 Yoshimura, Fayth K., 576 Steinheider, Gerhard, 375 Young, J. F., 547 Stephenson, John R., 914 Stirm, Stephan, 367 Wagner, E. K., 634 Stoltzfus, C. Martin, 1207 Wagner, Michael J., 10 Zannis-Hadjopoulos, Maria, 992 Strauss, Ellen G., 708 Waldron-Stevens, L. K., 192 Zezulak, Kathleen M., 1223 Strauss, James H., 708 Walker, Donald H., Jr., 1118 Ziff, Edward, 185 SUBJECT INDEX VOLUME 45

Abelson murine leukemia virus Bacteriophage 4)29 in vitro mutagenesis, 1028 morphogenesis and DNA-gp3, 383 reverse transcript P160 genomes cloned, 1195 Bacteriophage 4)92 site-directed deletions, 1028 endo-N-acetylneuraminidase, 367 Adeno-associated virus 2 Bacteriophage X nucleotide sequence and organization of genome, R-loops in recA-independent recombination, 971 555 Bacteriophage P22 Adenovirus type 2 restriction endonuclease cleavage site maps, 864 cycloheximide stimulation of early transcription, Bacteriophage PM2 683 tsl mutant with defective capsid, 226 "i" leader, RNA segment, 185 Bacteriophage T3 33K protein, structure and location, 251 effect of S. typhimurium DNA restriction systems, Adenovirus type 5 1147 EIA region and cell growth cycle, 192 ocr gene function, 1147 14K antigen in early region 4, 514 Bacteriophage T4 recombinants with SV40, 91 vegetative T4 DNA by electron microscopy, 813 transformation of rat cells, 1107 Bacteriophage T7 Adenovirus type 12 effect of S. typhimurium DNA restriction systems, cyt mutants, transformation of rat cells by, 1107 1147 EIA gene, SV40 vector, monkey cells, 408 ocr gene function, 1147 early region I expression transformed by recombi- stabilization and assembly, 665 nants, 1074 Bacteriophage UC-1 EIB gene, SV40 vector, monkey cells, 420 new, with E. coli tonA as receptor, 700 Adenovirus type 5-simian virus 40 hybrid Baculovirus palindromic family of viruses, 91 homologous DNA sequences in genomes, 961 Aedes albopictus cells Bovine leukemia virus' enucleated, Sindbis virus replication, 792 two species of covalently closed circular proviral Sindbis virus replication, 792 DNA, 1172 Agnoprotein SV40, subcellular localization, 428 AKR thymic lymphomas mink cell focus-inducing murine leukemia virus pro- viruses, 576 Cell fusion Aleutian disease virus of mink mediated by Sindbis virus glycoproteins, 1083 genome, characterization, 977 Chicken embryo fibroblasts Autographa californica nuclear polyhedrosis virus avian sarcoma virus-infected, particles from, 1207 homologous DNA sequences in genome, 961 Coliphage P1 polyhedrin and 1OK protein in infected cells, 215 morphogenesis, 1118 transcripts in infected cells, 215 mutant morphology by electron microscopy, 1118 Avian endogenous retrovirus ev-2 Corynebacteriophage )ct°" compared to Rous-associated virus-0, 868 restriction endonuclease map, 524 sequence of LTR and cellular sequences, 868 Corynebacterium diphtheriae Avian myeloblastosis-associated viruses corynebacteriophage wct", endonuclease map, 524 major envelope glycoproteins compared, 233 Coxsackievirus B3 subgroups A and B, glycoproteins compared, 233 temperature-sensitive mutants characterized, 1037 Avian myeloblastosis virus Coxsackievirus group B fifth major viral gag protein, plO, 648 membrane-bound virions, 832 gag protein plO, amino-terminal sequence, 885 c-rel gene homologous chicken DNA, 925 cellular homolog to reticuloendotheliosis virus on- monoclonal antibodies to reverse transcriptase, 859 cogene, 104 ppl9, digestion, 876 Cyanogen bromide protein ppl9 peptide binding to viral RNA, 876 digestion of avian myeloblastosis virus protein ppl9, Avian retrovirus MH2 876 subgenomic expression of v-myc, 133 Cycloheximide Avian RNA tumor virus stimulation of adenovirus type 2 transcription, 683 reverse transcriptase endonucleases, mechanism, Cytomegalovirus 727 human, compared with Herpesvirus aotus, 715 iv VOL. 45, 1983 SUBJECT INDEX v Defective interfering particle gag protein p0O vesicular stomatitis virus, deletion in, 766 amino-terminal protein sequencing, 885 DNA-binding protein avian sarcoma and leukemia viruses, 648, 885 HSV-l, gene analysis in temperature-sensitive mu- Glycoprotein tants, 354 C of HSV-1, mRNA analyzed, 634 HSV-2, gene analysis in temperature-sensitive mu- envelope, avian myeloblastosis-associated viruses, tants, 343 233 HSV-2, maturation in temperature-sensitive mu- released from vesicular stomatitis virus-infected tants, 332 cells, 80 Duck hepatitis B virus V3 (E) of Japanese encephalitis virus, 124 protein bound to viral DNA, 165 Gross passage A murine leukemia virus Leukemogenesis, 539 viral DNA cloned and LTR sequenced, 539 ElA region adenovirus type 5, effects on cell cycle, 192 adenovirus type 12, SV40 vector, monkey cells, 408 Early region 4 adenovirus type 5, 14K antigen, 514 Herpes simplex virus Early region IA antigenic variants, by monoclonal antibodies, 672 adenovirus, mRNAs, 594 gene transcription in vivo, 10 adenovirus, transcription initiation, 594 mechanisms of shutoff of Friend cell protein synthe- EIB gene sis, 241 adenovirus type 12, SV40 vector, monkey cells, 420 molecular genetics, 397 Encephalomyocarditis virus thymidine kinase DNA to cotransfect Friend cells, capsid precursor protein in rabbit lysates, 439 375 protein-RNA interaction, 1048 Herpes simplex virus type 1 UV-induced covalent linkages, 1048 antigenic variants, by monoclonal antibodies, 672 Endo-N-acetylneuraminidase gene product required for virus DNA encapsidation, in bacteriophages +92 and +1.2, 367 1056 Endonuclease glycoprotein C-encoding genome analyzed, 634 cap-dependent, influenza virus, 27 mutant defective in viral DNA release, 397 env gene temperature-sensitive mutants and DNA-binding Friend murine leukemia virus, nucleotide sequence, protein, 354 I Herpes simplex virus type 2 Epithelial cells DNA-binding protein maturation, 332 polarized, maturation of retroviruses in, 1065 monoclonal antibodies for protein identification and Epstein-Barr virus gene mapping, 1223 activation of latent genomes, 985 temperature-sensitive mutants and DNA-binding HR-1, highly methylated DNA, 482 protein, 332, 343 stimulation of chromosomal protein synthesis, 985 Herpesvirus aotus types 1 and 3 Equine herpesvirus genomes, polypeptides, versus human cytomegalo- types 1, 2, 3, genome relatedness, 855 virus, 715 Escherichia coli Host cells anti-pp6(WY' antigen, 462 adenovirus type 5 effects on cell cycle, 192 new phage UC-1, 700 cell fusion and Sindbis virus, 1083, 1090 transcription, murine leukemia virus LTR sequence, control of RFM endogenous retrovirus in RFM 456 mouse cells, 47 DNA, sites for mouse mammary tumor proviral DNA, 114 Feline sarcoma virus glycoprotein from vesicular stomatitis virus-infect- LTR homology to other retroviruses, 466 ed, 80 proviruses containing v-fes, 1004 involvement in Sindbis virus replication, 200 Flat revertants particles from cycloleucine-treated, avian sarcoma T antigen expression, 992 virus-infected, 1207 transformants reduced by SV40 tsA mutants, 992 protein synthesis, vesicular stomatitis virus mRNA Friend erythroleukemia cells effects, 206 DNA-mediated gene transfer, 375 receptor for mouse mammary tumor virus gene, 140 HSV shutoff of protein synthesis, mechanisms, 241 vesicular stomatitis virus-infected, glycoprotein re- Friend leukemia cells leased, 80 DNA-mediated gene transfer, 375 Human a interferon Friend murine leukemia virus binding to cells of different sensitivities, 1168 envelope gene, nucleotide sequence, 1 Human polyoma virus JC env gene, nucleotide sequence, 1 genomic structure, 73 Fujinami sarcoma virus infectious DNAs cloned from brain, 299 cytoplasmic localization of transforming protein, Hybrid-arrested translation 782 mapping of parvovirus H-l genes, 173 vi SUBJECT INDEX J. VIROL. "i" leader Lymphotropic papovavirus adenovirus type 2, RNA segment, 185 proteins coded, 872 Immunoglobulin complement-dependent mouse antibodies to retrovi- rus, 956 Influenza virus defective interfering mRNAs, 55 evolution, 547 Marek's disease herpesvirus A mutations in NS genes of field strains, 547 molecular characterization of antigen, 1228 nucleoprotein gene cloned, 434 MCF virus temperature-sensitive, cap-dependent endonucle- new, xenotropic, 447 ase, 27 type C, two biological classes in inbred mice, 275 Interferon MCF 247 virus a, binding to cells of different sensitivities, 1168 murine leukemia, sequence of 3' end, 291 antiviral effects in three murine cell lines, 1017 Measles virus effect on mengovirus RNA translation in L-cells, N,a-tosyl-L-phenylalanine chloromethyl ketone ef- 889 fect on polypeptides, 309 effect on Moloney murine leukemia virus-infected Mengovirus cells, 489 RNA translation in interferon-treated cells, 889 persistence of action in permeabilized cells, 895 3'-O-Methyl adenosine 5-Iododeoxyuridine inhibition of vaccinia virus, 1164 ifiduced mouse cells, murine leukemia virus expres- 3'-O-Methyl guanosine sion, 755 inhibition of vaccinia virus, 1164 MH2 virus subgenomic expression of v-myc, 133 Japanese encephalitis virus Minichromosomes envelope glycoprotein V3 (E) analyzed, 124 polyoma virus, DNA products, 585 JC virus polyoma virus, poly ADP-ribosylation of chromatin DNA replication origin, 73 proteins, 600 genomic structure, 73 Mink cell focus-forming virus (MCF) infectious DNAs cloned from human brain, 299 expression in 5-iododeoxyuridine-induced cells, 755 from Rauscher murine leukemia virus-infected cells, 995 murine leukemia viruses, genome structure, 740 K, killer virus type C, classes distinguished by oligonucleotides, S. cerevisiae, defective interfering virus mutants, 275 800 Mink cell focus-inducing virus new, xenotropic, 447 related proviruses in AKR thymic lymphomas, 576 La Crosse virus Mink cells RNA compared to snowshoe hare bunyavirus, 1155 SV40-transformed, mouse mammary tumor virus structure of small RNA ends, 882 expression, 148 Large T antigen, polyoma virus Moloney murine leukemia virus homology with SV40 large T antigen, 693 interferon effects on infected cells, 489 Large T antigen, SV40 morphogenetic block of mutant ts3, 1140 divalent cation binding in, 531 nonviremic mouse Mov substrains, 505 homology with polyoma virus large T antigen, 693 RNA-deficient particles in interferon-treated cells, phosphorylation sites, 442 489 phosphorylation sites localized, 315 Moloney murine sarcoma virus self-assembly of oligomers, 531 genealogy, 607 L-cells P85 polyprotein in tsl 0-infected cells, 1177, 1183 interferon-treated, inhibition of mengovirus, 889 recombinational junctions of v-mos in variants, 607 protein synthesis inhibited by vesicular stomatitis v-mos-encoded proteins in transformed cells, 1177 virus, 618 Monoclonal antibodies Leukemia against avian retrovirus reverse transcriptase, 859 inbred mice, 755 against rotaviruses, 1143 Long terminal repeat for antigenic variants of HSV-1, 672 avian retrovirus ev-2, sequence, 868 to Rous sarcoma virus pp6(Yrc, 1190 feline sarcoma virus, homology to retroviruses, 466 to two HSV-2 glycoproteins, for identification and Gross passage A murine leukemia virus, sequence, mapping, 1223 539 use for analysis ofJapanese encephalitis virus glyco- length variation in murine leukemia virus DNA protein, 124 clones, 484 Mosquito cells mouse mammary tumor virus, protein coding poten- Sindbis virus replication, 792 tial, 941 Mouse chromosome 16 murine leukemia virus, and E. coli transcription, 456 mouse mammary tumor virus gene mapped, 140 VOL. 45, 1983 SUBJECT INDEX vii Mouse mammary tumor virus Polyoma virus cellular receptor and gene mapping, 140 infectivity-loss mutation in large T antigen, 693 endogenous proviral DNA in mouse tumors, 114 large T antigen with homology to that of SV40, 693 expression in SV40-transformed mink cells, 148 minichromosomes, in vitro DNA products, 585 glucocorticoid-dependent DNA expression, 148 minichromosomes, poly ADP-ribosylation of chro- LTR, protein coding potential, 941 matin proteins, 600 mRNA Porcine parvovirus defective interfering, influenza virus, 55 purification and antigenic properties, 842 HSV-1, encoding glycoprotein C, 634 pp6(src vesicular stomatitis virus, effect on host cell protein antiserum produced with E. coli antiAen, 462 synthesis, 206 Rous sarcoma virus, monoclonal antibody, 1190 Murine leukemia virus proto-amv DNA cloned DNA from Gross passage A virus, 539 clones from leukemic chicken DNA library, 925 expression after 5-iododeoxyuridine induction of cells, 755 LTR sequence and E. coli transcription, 456 MCF 247, sequence of 3' end, 291 mink cell focus-forming, induced, genome, 740 Rabbit parvovirus mink cell focus-inducing, related proviruses, 576 structural and nonstructural proteins, 627 new mink cell focus-inducing virus, 447 Radiation leukemia viruses nonexpressed, activation by DNA transfection, 950 new class from radiation-induced thymomas of radiation-induced, new class, 565 mice, 565 WN1802N, recombinant DNA clones, 484 Rat cells xenotropic, new virus derived from, 447 transformation by adenovirus 12 cyt mutants, 1107 xenotropic, proviral DNA in mouse genomes, 473 Rauscher murine leukemia virus Murine sarcoma virus glycoproteins gp69 and gp7l, 995 P85 polyprotein in tslO-infected cells, 1177, 1183 new glycosylated gag gene product, 1200 v-mos-encoded proteins in transformed cell lines, new viruses from infected JSL-V9 cells, 995 1177 Rauscher spleen focus-forming virus genetic structure, 1217 Newcastle disease virus Reticuloendotheliosis virus temperature-sensitive mutants, thermostability, 18 c-rel, cellular homolog to v-rel oncogene, 104 NIH 3T3 cells Retrovirus Moloney murine leukemia virus-infected, interferon basolateral maturation in polarized epithelial cells, effects, 489 1065 RNA-deficient virus in interferon-treated, 489 ecotropic, neurotropic, cloning of DNA, 1159 NS genes RFM strain, control in RFM mouse cells, 47 influenza virus, mutations in, 547 type C, strain RFM, 47 Nucleocapsid protein wild mouse, cloning of infectious viral DNA, 1159 vesicular stomatitis virus gene coding for, 773 Retrovirus, mouse neutralizing capacity of antibodies, 956 Retrovirus, type C plO new, gene product of, 914 fifth major avian viral gag protein, 648, 885 RFM endogenous retrovirus P85 control in RFM mouse cells, 47 polyprotein encoded by Moloney murine sarcoma Rotavirus virus, 1177, 1183 neutralizing monoclonal antibodies, 1143 Papovavirus, lymphotropic Rous-associated virus-0 proteins coded, 872 compared to avian retrovirus ev-2, 868 Parvovirus Rous sarcoma virus porcine, purification and antigenic properties, 842 inactive src gene product from point mutation, 1211 rabbit, proteins analyzed, 627 monoclonal antibody to protein pp6(Yrc, 1190 Parvovirus H-I Prague C, reverse transcriptases, 727 nucleotide sequence and gene mapping, 173 site-directed mutagenesis, 1211 Picornavirus two Theiler's groups with similar nucleotides, 1150 Plasmid pACYC184 tetracycline gene, SV40 promoters, 478 Poly(ADP-ribose) polymerase Saccharomyces cerevisiae poly ADP-ribosylation of polyoma virus minichro- K, killer virus, defective interfering mutants, 800 mosomes, 600 Salmonella typhimurium Polyhedrin DNA restriction systems and bacteriophages, 1147 A. californica nuclear polyhedrosis virus-infected Sendai virus cells, 215 3' termini in defective interfering RNAs, 659 viii SUBJECT INDEX J. VIROL. Simian virus 40 12-O-Tetradecanoyl-phorbol-13-acetate (TPA) agnoprotein, subcellular localization, 428 inducer of Epstein-Barr virus gene expression, 985 divalent cation binding in large T antigen, 531 Theiler's murine encephalomyelitis virus DNA cotransfected with HSV DNA, 375 proteins specified in tissue culture, 4% large T antigen phosphorylation sites localized, 315 same 5'-end nucleotides in two isolates, 1150 large T antigens, self-assembly of oligomers, 531 Thymidine kinase nascent late transcripts, 5' termini, 264 polypeptide in vaccinia virus, 62 new complementation group G, 36 N,o-Tosyl-L-phenylalanine chloromethyl ketone phosphorylation sites in large T antigen, 442 (TPCK) promoters and tetracycline resistance in pA- effect on measles virus polypeptides, 309 CYC184, 478 protein LP-1 defining new complementation group, 36 recombinants with adenovirus type 5, 91 Vaccinia virus recombinants with adenovirus type 12 EIA gene, growth and virus-specific RNA synthesis inhibited, 408 1164 recombinants with adenovirus type 12 E1B gene, inhibition by methylated nucleoside analogs, 1164 420 protein synthesis inhibitor solubilized from virions, super T antigen from SV40-transformed cells, 1098 452 transformants induced by tsA mutants, 992 thymidine kinase and other genes, 62 transformed mink cells, 148 Vesicular stomatitis virus vector for influenza virus nucleoprotein gene, 434 defective interfering particle, recombination event, Sindbis virus 766 cell fusion at low pH, 1090 glycoprotein from virus-infected cells, 80 envelope protein conformation at low pH, 1090 inhibition of L-cell protein synthesis, 618 host cell involvement in viral replication, 200 nucleocapsid protein gene, expression, 773 polycaryocyte formation mediated by, 1083 nucleocapsids, cell-free synthesis and assembly, 155 proteins mediating cell fusion, 1083 viral mRNA inhibition of host cell protein synthesis, replication in Aedes albopictus culture, 792 206 Snowshoe hare bunyavirus v-mos sequence RNA compared to La Crosse bunyavirus, 1155 junctions in Moloney murine sarcoma viruses, 607 Super T antigen v-myc gene activities, 901 subgenomic expression in MH2 virus, 133 from SV40-transformed cells, properties, 1098

Temperature-sensitive mutants Western equine encephalitis virus Newcastle disease virus, 18 structural proteins, 708 INDEX TO DATE OF ISSUE

Month Date of Issue Pages January 17 December 1982 1-488 February 18 January 1983 489-899 March 17 February 1983 901-1234