Fu-Tong Liu, M.D., Ph.D

Fu-Tong Liu, M.D., Ph.D.

Clinical Interests Fu-Tong Liu specializes in general dermatology with a particular interest in inflammatory skin disorders, including atopic dermatitis, psoriasis, and autoimmune skin diseases, as well as mast cell diseases, such as urticaria and mastocytosis.

Research/Academic Interests As an allergy and immunology researcher, he is a pioneer and leading investigator in the study of a family of proteins called galectins. His research is focused on their functions in inflammation and immunity, as well as cancer progression and adiposity.

Title Distinguished Professor Emeritus and Chair Emeritus

Specialty Cancer, Dermatology

Department Dermatology

Division Dermatology

Center/Program Affiliation UC Davis Comprehensive Cancer Center

Address/Phone Cannery Building, Dermatology, 3301 C St. Suite 1300-1400 Sacramento, CA 95816 Phone: 916-734-6111

Additional Phone Physician Referrals: 800-4-UCDAVIS (800-482-3284)

Languages Chinese (Mandarin)

Education M.D., University of Miami School of Medicine, Miami FL 1987 Ph.D., Organic Chemistry, University of Chicago, Chicago IL 1975 B.S., National Taiwan University, Taipei, Taiwan, 1970 Residency UC San Diego, San Diego CA 1990-1993

Board Certifications American Board of Dermatology, 1993

Professional Memberships American Academy of Dermatology American Association for the Advancement of Science American Association of Immunologists American Chemical Society American Society for Clinical Investigation

Fu-Tong Liu, M.D., Ph.D.

American Society for Investigative Pathology Association of American Physicians Society of Investigative Dermatology Honors and Awards First KIA Laureate, the 28th Khwarizmi International Award, 2015 Fellow, American Association for the Advancement of Science, 2013 Academician, Academia Sinica, Taiwan, 2012 Lu Yau-Chin Memorial Lectureship, Taiwanese Dermatology Society, 2006 Joan Oettinger Memorial Award (Cancer and Pulmonary Research), UC Davis, 2005 Select Recent Publications Chen, H.-L., Chiang, P.-C., Lo, C.H., Lo, Y.H., Daniel K. Hsu, D.K., Chen, H.Y., Liu, F.-T. Galectin-7 regulates keratinocyte proliferation and differentiation through JNK-miR-203-p63 signaling. J Invest Dermatol, 2016;136:182-91.

Wang, S.-F., Tsao, C.-H., Lin, Y.-T., Hsu, D.K., Chiang, M.-L., Lo, C.-H., Chien, F.-C., Chen, P., Chen, Y.-M., Chen, H.-Y., Liu, F.-T. Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6. Glycobiol, 2014;24:1022-35.

Fermin-Lee, A, Chen, H.-Y., Wan, L., Wu, S.-Y, Yu, J.-S., Huang, A.C., Miaw, S.-C.,Hsu, D.K., Wu-Hsieh, B.A., and Liu, F.-T. Galectin-3 modulates Th17 responses by regulating dendritic cell cytokines. Am J Pathol, 2013;183:1209-22.

Choy, D.F., Hsu, D.K., Seshasayee, D., Fung, M.A., Modrusan, Z., Martin, F. Liu, F.T*., and Arron, J.R*. Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation. J Allergy Clin Immunol, 2012;130:1335-1343 (*co-corresponding author).

Liu, W., Hsu, D.K., Chen, H.-Y., Yang, R.-Y., Carraway KL 3rd, Isseroff RR, Liu, F.-T. Galectin-3 regulates intracellular trafficking of EGFR through Alix and promotes keratinocyte migration. J Invest Dermatol. 2012;132:2828-37.

Fu-Tong Liu, M.D., Ph.D.

Yang, R.-Y., Yu, L., Graham, J., Hsu, D.K., Lloyd, K.C., Havel, P.J., and Liu, F.-T. Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice. Proc Natl Acad Sci USA 2011;108:18696-701.

Saegusa, J., Hsu, D.K., Chen, H.-Y., Yu, L., Fermin, A., Fung, M.A., and Liu, F.-T. Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis. Am J Pathol, 2009;174:922-931.

Chen, H-Y., Fermin, A., Vardhana, S., Weng, I-C., Lo, K.F.R., Chang,E-Y., Maverakis, E., Yang, R. Y., Hsu, D.K., Dustin, M., and Liu, F.-T. Galectin-3 negatively regulates TCR-mediated CD4 T cell activation at the immunological synapse, Proc Natl Acad Sci USA, 2009;106:14496-14501.

Hsu, D.K., Chen, H.-Y., Yu, L., Chernyavsky, A.I., Grando, S.A., and Liu, F.-T. Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells. J Invest Dermatol, 2009;129:573-83.

Liu, F-T. and Rabinovich, G.A. Galectins as novel modulators of tumor progression. Nature Rev Cancer, 2005;5: 29-41.