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Research Journal of Pharmaceutical, Biological and Chemical Sciences ISSN: 0975-8585 Research Journal of Pharmaceutical, Biological and Chemical Sciences Risk Alleviation Of Pesticides In Agriculture: From History To Analytical Techniques. Jojiya Grace George, and Aneesh TP*. Amrita School of Pharmacy, Amrita University, Amrita Vishwa Vidyapeetham,AIMS Health Sciences Campus, Kochi, Kerala, India. ABSTRACT Population explosion leads to the exploitation of agricultural field to meet the supply of food products (mainly vegetables and fruits). Before first century onwards the usage of pesticide was started to promote the growth of food products and in the present, biotechnological strategies are adopted for pest control along with synthetic pesticides. The demand for maximization of productivity is achieved by the application of synthetic pesticides. Apart from its benefits, its misuse predominates and generates serious consequences. The categorization of pesticides can be done according to their source, mode of action, nature of pest and also on their chemical nature. Excessive and inappropriate usage of pesticides undoubtfully leads to poisoning and various instances of pesticide poisoning are being reported every year. These incidences of pesticide poisoning tragedy include Endosulphan poisoning, Tragedy of Tauccamarca, Seveso disaster etc. These pesticides create serious health hazards ranging from short term effects like vomiting to long term effects including cancer and neurological problems. Analytical laboratories contribute for reducing its intensity to humans and to environment through preliminary screening techniques and comprehensive screening procedures like HPLC, LCMS, GC and GCMS. These are efficient and powerful methods of pesticide determination in vegetables and fruits. The scenario of pesticide usage is complex and hence, care has to be taken by the government and public to lower its usage and to promote environmental stability and social health. Keywords: Pesticides, Chromatography, vegetables, fruits, poisoning *Corresponding author January – February 2017 RJPBCS 8(1) Page No. 1202 ISSN: 0975-8585 INTRODUCTION The human population is growing continuously and it has been observed that there is a tremendous increase in population for the last 50 years. Increase in population demands more agricultural productivity [1] and for the quantum yield of crops, infestation of the pest on fruits and vegetables has been decreased with the help of pesticides. To limit the loss of crops produced due to the attack of pests there is a need to widen the plant protection umbrella and propagate the judicial use of crops. The judicious use of pesticides can protect the crops and increases their yielding capacity [2]. Pesticides are biocides which are used to kill pests. They may be of natural or artificial in origin. They can be insecticides, rodenticides, herbicides, fungicides etc [3]. Pesticides have innumerable benefits. These include crop protection, improvement of food quality and also the prevention of vector-borne diseases [4]. But these are misused nowadays largely. Misuse of pesticide includes the selling of banned pesticide, over usage of pesticides and also its improper usage without following the guidelines. Illiterate distribution patterns of pesticide in agricultural practices lead to its persistence in the agricultural fields leading to environmental pollution. These can also create serious consequences on food samples (vegetables and fruits) finally reaching man through food [5]. Due to its widespread usage in agriculture for more food products, it can be indirectly considered as “Poison in Plates”. According to the data extracted in 2014, the statistics of pesticide sale reveal the use of 43.8% of fungicides and bactericides, 33.2% of herbicides and haulm destructors, 14.2% of other plant protection products, 5.2% of insecticides and ascaricides, 3.2% of plant growth regulators and 0.4% of molluscicides. The origin of the use of pesticides and its advancement till the present scenario is given in table below [6] Table.1. Origin of pesticides and its advancement Time period Pesticide used Ancient times Ashes, common salts, and bitters 1st century Arsenic, suggestion of soda and olive oil for treatment of legumes (Pliny the Elder, a Roman naturalist-Historia naturalis) 16th century Arsenicals and nicotine in the form of tobacco extracts (Chinese farmers) 1850 Pyrethrum, soap and a wash of tobacco, sulfur, and lime also used 1867 The pigment Paris green (impure form of copper arsenite), Paris green and kerosene oil emulsion 1896 Bordeaux mixture (CuSO4 & Ca(OH)2), and selective chemical herbicides 1900 Dilute Sulfuric acid, copper nitrates, potassium salts 1900 -1950 Sodium arsenite solutions become the standard herbicides and are used in large quantities 1913 Organomercury seed dressing 1913- 1939 Dithiocarbamates fungicides used in US 1939 Insecticidal potential of DDT discovered in Switzerland. Chlorinated hydrocarbons ( DDT, BHC, dieldrin, Aldrin & chlordane) 1950s Fungicides captan, glyodin and organophosphorous insecticide Malathion 1961 DDT registered for use on 34 different crops as pesticide usage dramatically increases 1962 Bio accumulation and long-term toxicity and pest resistance became evident. Stoppage of DDT usage and other chlorinated compounds by farmers. Favor of the use of Organophosphates and Carbamates 1972 Environmental Protection Agency revoked the use of DDT on all food sources in the United States. The World Health Organization, however, still reserves the right to use DDT on particularly virulent outbreaks of malaria January – February 2017 RJPBCS 8(1) Page No. 1203 ISSN: 0975-8585 1972-1980 Herbicidal sulfonylureas, neonicotinoids, glyphosate, synthetic fungicides such as metaxyl and triadimefron,and light-stable pyrethroid pesticides introduced 1990s Integrated pest management, intensified research on biological pest control methods and other alternatives to pesticides. 1990-1995 Increased interest in Integrated Pest Management (IPM) programs 2000 Wide spread usage of IPM techniques organic farming excluding the usage of synthetic pesticides. 2010-15 Involvement of genetic engineering and biotechnological methods to control the usage of pesticides eg. baculoviruses Integrated Pest Management (IPM) IPM is an expansive approach urged mainly by ecologists and environmentalists for the pest control in an economical manner. The main objective of IPM is pest control giving consideration for the acquirable pest control techniques without causing any threat to the ecosystem and human beings. It is mainly employed in agricultural and horticultural practises with the main intention of controlling pests, incorporating organic farming and barring the synthetic pesticides [7]. IPM focuses on the long term pest control which involves the process of checking the admissible level of pests and then monitoring the economic injury level or the safety standards. If it is crossed, then mechanical and biological methods of pest control are initiated and then if the condition requires the use of synthetic pesticides, then synthetic ones harmless to the surroundings are employed. IPM techniques are advantageous since it is facile, cost saving and economically compactable. Classification of Pesticides Pesticides can be classified into different types depending upon the source from which they are derived, mode of action, nature of the pest, on the basis of its chemical nature, functional group etc. Mainly they are classified as fungicides, herbicides, insecticides, molluscicides, rodenticides and insect repellents. Herbicides are used for killing weeds in domestic as well in commercial agricultural and horticultural practices. Eg. Dequat, pentachlorophenol, paraquat. Insecticides are widely used in agriculture for killing of insects. Although some insecticides cause serious health hazards, these are beneficial in the treatment of ectoparasitic infections and scabies. They enter the human body through skin or through systemic absorption. Insecticides may further be classified as carbamates (eg.carbosulfan, bendiocarb), chlorinated (chlordane, dieldrin, endosulfan), organophosphorus (ethion, phosmet, malathion, temefos), pyrethroid (Eg. permethrin, cypermethrin, bifenthrin). Molluscicides are used to control snails, for eg. bulinus (a freshwater snail vector) is controlled by the applying of nicloamide. As the name suggests, rodenticides are used to kill rodents (rats and mice). Eg. aluminium phosphide, squill, norbormide, difenacoum. Certain rodenticides (such as warfarin) are used as an anticoagulant medication [8]. On chemical basis pesticides are classified into four classes as Organophosphorus, Organochlorine, Carbamates and Pyrethroid pesticides. Present studies specify that Organophosphorus pesticides are more used when compared with organochlorine pesticides in vegetables for the control of pests. The widespread usage of pesticides in the agricultural field and also during the time of transportation and handling in the selling market can drastically create a boon to all living organisms including human beings. Studies reveal that the vegetables and fruits purchased from markets are intensively contaminated with traces of synthetic pesticides. In a decade, the vegetables purchased from the supermarkets are found to double its content of pesticide use. Although these amounts are below the internationally recognised safety levels, its bioaccumulation even at low levels proves harmful. Adverse Effects of Pesticides The impact of pesticides is not limited to human beings,
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