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INDEX

Volume 21 3, April-June 1980

Aarbakke, J., see Gadeholt, G., tyl xanthine (MIX) on am- Anderson, D. F., Phernetton, T. muscle (dog), 150 196 phibian neuromyal transmis- M. and Rankin, J. H. G.: The Atria, positive isotropic action of Abboa-Offei, B. E., see Casey, F. sion, 586 measurement of placental digoxigenin, effects of sodium B., 432 Akera, T., see Yamamoto, S., 105 drug clearance in near-term (guinea pigs), 105 Acetaldehyde, effects on testicu- sheep: Indomethacin, 100 Auber, M., see HalUshka, P. V., tar steroidogenesis (rats), 228 depression of myo-inositol 1- Anesthetics, local, frequency-de- 462 Acetaminophen phosphate in cerebral cortex pendent sodium channel Ayachi, S. and Brown, A. M.: Hy- probe analysis, hepatic gluts- (rat), 24 block in nerve (frog), 114 potensive effects of cardiac thione turnover in vivo deter- tolerance to (mice), 309 Angiotensin, comparison with ox- glycosides in spontaneously mined by (rats), 54 [‘4C]Allantoin, renal clearance ytocin in effect on prosta- hypertensive rats, 520 toxicity in lymphocytes in vitro (rabbit), 168 glandin release in IsOlated (man), 395 Allen, J. C., see Seidel, C. L., 514 uterus (rat), 575 Bainbridge, C. W. and Heistad, D. Acetazolamide Allergy, antiallergic properties of , effects on body tem- D.: Effect of on inhibition of bone resorption, SQ 13,847 and SQ 12,903 perature (mice), 273 ventilatory responses to do- lack of hypophosphateania (rats, mice, guinea pigs), 432, Anoxia, -induced contractions of pamine in man, 13 (rats), 441 437 coronary arteries, inhibition Barbitol, enhancement of effects inhibition of carbonic ashy- Allison, J. H. and Cicero, T. J.: by lidoflazine (dog), 179 of mus,cimol on dopamine drase, relation to cerebrospi- Alcohol acutely depresses Antibiotics, disposition, effects of turnover in retina (rat), 332 nat fluid (cats), 321 myo-inositol 1-phosphate 1ev- furosemide (rabbit), 600 Barbiturates, enhancement of ef- Acetylation, p-aminohippurate, ala in the male rat cerebral Antimycin A, inhibition of sodium fects of on dopa- by kidney (mice), 350 cortex, 24 transport and metabolism mine turnover in retina (rat), Acetylator phenotype Alloxan, -induced diabetes, alter- (toads), 375 332 inheritance (mice), 480 ations in dopamine-$-hy- Antinociception, - Barnett, A., see lorlo, L C., 445 relationship ofantinuclear anti- droxylase and norepineph- mediated, spinal cord phar- Baughman, W. L, see Dickinson, bodies to (mice), 485 rise (rats), 18 macology of (rats), 525 R G., 38 Acetylhydrazine, metabolism in p-Aminobenzoic acid, effects on Antinuclear antibodies, relation- Beek, D., see Kenakin, T. P., 406 vivo, hepatotoxic effect of bleomycin-induced pulmo- ship to acetylator phenotype Behavior (rats), 364 nary fibrosis (hamsters), 425 (mice), 485 -induced attenua- Acetylisoniazid, metabolism in p-Aminohippurate, uptake and Antipyrine, half-life, hepatic, ef- tion of effects of 9-tetrahy- vivo, hepatotoxic effect of acetylation by kidney (mice), fects ofethanolfeeding (rats), drocannabinol on temporal (rats), 364 350 196 discrimination (pigeons), 247 t-a-, enterohe- /1-Aminopropiomtrile, effects on Antonissen, L A., Mitchell, R. W., schedule-controlled, effects of patic circulation (rats), 284 bleomycin-induced pulmo- Kroeger, B. A., Kepron, W., on (rats), Acetylsalicycic acid, antinocicep- nary fibrosis (hamsters), 425 Stephens, N. L and Bergen, 497 five effects, blockade by l-ly- 4-Aminopyridine and nicotine, ac- J.: Histamine pharmacology use of conditioned suppression sine (rat), 445 tion on sympathetic nerve in airway smooth muscle to evaluate neuroleptic-in- Actomyosin, in aorta, effect of hy- terminals (cat), 133 from a canine model of duced avoidance training dralazine-induced hypoten- Aminopyrine, antinociceptine ef- asthma, 150 (rat), 623 sion (rats), 514 fects, blockade by l-lysine Aorta Belinsky, S. A., see Reinke, L A., Adenosine 3’:S’-monophosphate (rat), 445 actomyosin and mechanical 70 (see Cyclic AMP) properties, effect of hydrala- Belmaker, R H., see Ebstein, R ADP, effects of 6-keto-E1 on pal- effect on cerebral capillary zine-induced hypotension P., 161 monary hypertensive re- permeability in vivo (rat), 313 (rats), 514 Benzolamide, inhibition of car- sponse to (cats), 468 interaction with alpha and alpha adrenergic receptor, ef- bomc anhydrase, relation to Adrenergic , apha, spinal muscarinic prejunctional re- fects of analogs cerebrospinal fluid (cats), 321 cord pharmacology of anti- ceptors in saphenous vein (rat), 267 Beninger, R. J., Mason, S. T., nociception mediated by (dog), 616 Arachidonic acid, -stimulated Phillips, A. G. and Fibiger, H. (rats), 525 short-circuit current in iso- C.: The use of conditioned Adrenergic receptor (see also effects on unit activity in medial lated urinary bladder (toads), suppression to evaluate the Adrenoreceptors) thalamus (rat), 580 462 nature of neuroleptic-in- ajpha, aorta, effects of clom- -induced mydriasis (cat), 49 Artery - duced avoidance deficits, 623 dine analogs (rat), 267 d-Amphetamine, acute responses coronary lidoflazine inhibition Bergen, J., see Antonissen, L A., Adrenoreceptors (see also Adre- to, role of amphetamine me- of contractions caused by 150 nergic receptors) tabolites (rats), 504 norepinephrine, 5-hydroxy- Berkowitz, B. A., Head, R., Joh, agonist, beta-i, prenalterol, tis- D-Amphetaimne, influence on tryptamine, potassium, an- T. and Hempstead, J.: Exper- sue selectivity (cats), 406 brain striatal-reduced biop- oxia and ergonovine maleate imental diabetes: Alterations beta, blocking activity, relation- term (rat), 569 (dog), 179 in circulating dopamine-$- ship with pharmacokinetics Anal coronary, smooth muscle, con- hydroxylase and norepineph- of dt-and l- (rab- effects on discrimination of tractile responses to potas- rise, 18 bit), 628 electric shock (monkeys), 234 sium and histamine, effects of Berner, P. F., DiSalvo, J. and Age, effects on hepatic glutathi- narcotic, tolerance to and en- R02-2985 (pig), 59 Schwartz, A.: Differential in- one turnover in vivo (rats), hancement of (rats), 418 systolic pressure, effects of car- hibitory effects of the iono- 54 , attenuated aver- diac glycosides (rats), 520 phore RO2-2985 (X537A) on Akasu, T. and Karczmar, A. G.: siveness of electric shock dur- Asthma, canine model, histamine contractile responses to po- Effects of 1-methyl-3-isobu- ing (rat, monkey), 128 effects in airway smooth tassium and histamine in cor- 633 634 Index Vol. 213

onary artery smooth muscle, netics and plasma protein (dog), 509 a-Chloralose, effects on systolic 59 binding in (rats, man), 97 Carbon, R W., see Ruiz, C. E., arterial pressure and heart Biopterin, brain striatal-reduced, , effects on schedule- 414 rate (rats), 520 Influence of D-amphetanune controlled behavior (rats), Carpenter, H. M. and Mudge, G. Chiornaltrexamine, alkylating (rat), 569 497 H.: Uptake and acetylation of narcotic antagonist, pharma- Bircher, J., see Zysset, T., 173 p-aminohippurate by slices of cology (mice), 539 Bladders Caffeine mouse kidney cortex, 350 Chioroxymorphamine, alkylating urinary, isolated, effects of as- effects on unit activity in medial Caruso, T. P., Larson, D. L, Por- narcotic agonist, pharmacol- achidonic and eicosatrienoic thalamus (rat), 580 toghese, P. S. and Takemori, ogy (mice), 539 acids on short-circuit current -induced malignant hyperther- A. E.: Pharmacological stud- Choleretic effect, of valproic acid in (toad), 462 mis, properties of muscle ies with an alkylating nar- (monkey), 38 effects of furosemide and etha- (pig), 91 cotic agonist, chioroxymor- Choline uptake, sodium-depen- crynic acid on sodium trans- Calcitonin, inhibition of bone re- phamine, and antagonist, dent, brain, effects of h9- port and CO2 production in sorption hypophosphatemia , 539 and (toad), 383 after (rats), 441 Casey, F. B., Abboa-Offei, B. E. (rats), 216 effects of metabolic and trans- Calcium and Marretta, J.: Antiallergic Choroid plexus, carbonic ashy- port inhibitors on sodium effect on action of nicotine and properties of SQ 13,847, an drase inhibition, relation to transport and CO2 produc- 4-aminopyridine on sympa- orally effective agent. I. Ac- cerebrospinal fluid (cats), 321 tion in (toads), 375 thetic nerve terminals (cat), tivity in vivo, 432 Chou, D. T., Forde, J. H. and effects ofsodium and potassium 133 Catecholamines (see also specific Hirsh, K. R: Unit activity in on metabolism and sodium effect on vanadate inhibition of names) medial thalamus: Compara- transport in (toad), 390 renin secretion from kidney -induced malignant hyperther- tive effects of caffeine and Bleomycin, -induced pulmonary (rat), 144 mia, properties of muscle amphetamine, 580 fibrosis, evaluation of antifi- role in opiod action in ileum (pig), 91 Chronotropic effects, comparison brotic drugs in (hamsters), (guinea pig), 188 modulation of -in- of prostacydlin and prosta- 425 synaptosomal uptake, inhibi- duced electrophysiological glandin E2 (dog), 261 Blood pressure, effect of p-by- tion by ethanol (rat, mice), responses in cerebral cortex Churchill, M. C., see Churchill, P. droxyamphetamine and p- 562 by (rats), 205 C., 144 hydroxynorephedrine (rats), Calcium-45 secretion, ionophore-induced, Churchill, P. C. and Churchill, M. 504 high and low affinity binding in 241 C.: Vanadate inhibits resin Blood vessels, increased resist- aortic smooth muscle, effects Catravas, J. D. and Gillis, C. N.: secretion from rat kidney ance by propranolol (dogs), of norepinephrine and cal- Pulmonary clearance of slices, 144 64 cium (rabbit), 450 [‘4C] - 5 - hydroxytryptamine Cicero, T. J., see Allison, J. H., 24 Bohn, D. L., see Fanelli, G. M., Camp, A. E., see Fanelli, G. M., and [3H]norepinephrine in Circadian rhythms, in biological Jr., 596 Jr., 596 vivo: Effects of pretreatment response and disposition of Bone, resorption, sulfonamide in- Cannabidiol, effects on sodium- with or , ethanol (mouse), 1 hibition, lack of hypophos- dependent choline uptake in 120 Circulation, enterohepatic, of 1-a- phatemia (rats), 441 brain (rats), 216 Cefazolin, disposition, effects of acetylmethadol (rats), 284 Bowdle, T. A., Neal, G. D., Levy, Cantacuzene, D., see Goldberg, L. furosemide (rabbit), 600 cis-Platinum, nephrotoxicity R. H. and Heimbach, D. M.: I.,509 Cells (rat), 545, 551 pharmacokinetics Capillary, cerebral, permeability cardiac, chick embryonic, in Clapp, J. F., HI, see Szeto, H. H., in burned rats and plasma in vivo, effect of tricycic an- culture, interaction with sea 346 protein binding of phenytoin tidepressants (rat), 313 anemone polypeptide toxin, Clearance in burned patients, 97 Carbachol, -induced membrane 607 placental, of indomethacin in Bowers, R. L, see Seidel, C. L., potential changes in lacrimal lacrimal gland acinar, mem- near-term sheep, 100 514 gland acinar cells (rats), 473 brane potential changes in- pulmonary, of [‘4C]-5-hydroxy- Brain (see also specific part) Carbon, C., Contrepois, A., Vig- duced by carbachol and epi- tryptamine and [3H]norepi- cerebral, capillary permeability neron, A.-M. and Lamotte- nephrine (rats), 473 nephrine in vivo, effects of in vivo, effect of tricyclic an- Barrillon, S.: Effects of furo- Central nervous system (see imipramine or cocaine (rab- tidepressants (rat), 313 semide on extravaseular dif- Nervous system, central) bit), 120 effects of substituted phenyl- fusion, protein binding and Cerebral cortex renal, of[’4C]allantoin (rabbit), ethylamines on serotonin me- urinary excretion of cephalo- alcohol depression of myo-ino- 168 tabolism (mice), 254 sporins and aminoglycosides sitol 1-phosphate in (rat), 24 renal, of hydrochlorothiazide, effects of i9-tetrahythocanna- in rabbits, 600 catecholamine modulation of effect ofindomethacin (chim- binol and cannabidiol on so- Carbon dioxide enkephalin-induced electro- panzee), 596 dium-dependent choline up- production and sodium trans- physiological responses in Clomdine take in (rats), 216 port of bladders, effects of fu- (rats), 205 analogs, effects on alpha adre- mesencephalic reticular forma- rosemide and ethacrynic acid Cerebrospinal fluid, relation to nergic receptors in aorta tion, effects of and (toads), 383 carbonic anhydrase inhibi- (rat), 267 methionine-enkephalin on production and sodium trans- tion in choroid plexus (cats), differentiation of postsynaptic neuronal firing in (rats), 355 port of bladders, effects of 321 alpha adrenergic receptors in noradrenaline-induced cyclic metabolic and transport in- Chalazonitis, A., Rice, P. J. and tissues by (rat), 557 AMP accumulation in, effect hibitors (toads), 375 Zigmond, R. E.: Increased Clonixin, antinociceptive effects, of lithium (rats), 161 production and sodium trans- ganglionic tyrosine hydrox- blockade by l-lysine (rat), 445 striatal-reduced biopterin, in- port of bladders, effects of so- ylase and dopamine-fl-hy- Cocaine, effects on pulmonary fluence of D-amphetamlfle dium and potassium (toad), droxylase activities following clearance of [‘4C]-5-hydroxy- (rat), 569 390 preganglionic nerve stimula- tryptamine and [3H]norepi- Brody, T. M., see Yamamoto, S., Carbonic anhydrase, inhibition in tion: Role of nicotinic recep- nephrine in vivo (rabbit), 120 105 choroid plexus, relation to Ce- tors, 139 , effects on body temper- Brown, A. M., see Ayachi, S., 520 rebrospinal fluid (cats), 321 Chan, W. Y.: The separate utero- ature (mice), 273 Bullard, W. P., see Mandell, A. J., Cardiac glycosides, effects on sys- tonic and prostaglandin-re- Collins, J. G. and Roppolo, J. R: 569 tolic arterial pressure and leasing actions of oxytoxin. Effects of pentobarbital and $-Bungarotoxin, parasympathetic heart rate (rats), 520 Evidence and comparison ethanol upon single-neuron nerve blocking action (guinea Cardiovascular actions, of dopa- with anglotensin and metha- activity in the primary so- pig), 156 mine and norepinephrine, ef- choline in the isolated rat matosensory cortex of the Burns, phenytoin pharmacoki- fects of ring fluorination uterus, 575 rhesus monkey, 337 1980 Index 635

Collis, M. G. and Shepherd, J. T.: olism (toads), 375 bral cortex, catecholamine Interaction of the tricycic Diols, aliphatic, suppression of modulation (rats), 205 analgesia, effects of prior ad- antidepressant amitriptyline ethanol withdrawal syn- Elimination, of valproic acid ministration and pain (rats), with prejunctional alpha and drome (rats), 9 (monkey), 38 418 muscarinic receptors in the N,N-di-n-propyl dopamine, ef- Enkephalin, -induced electro- effects on body temperature dog saphenous vein, 616 fects on dopamine vascular physiological responses in (mice), 273 Colpaert, F. C., Niemegeers, C. J. receptors (dogs), 370 cerebral cortex, modulation Fetus, renal tubular secretion of E., Janssen, P. A. J. and Ma- DiSalvo, J., see Berner, P. F., 59 by catecholamines (rats), 205 meperidine by (lamb), 346 roll, A. N.: The effects of Diuresis, hydrochlorothiazide, Enterohepatic circulation, of 1-a- Fibiger, H. C., see Beninger, R. J., prior fentanyl administration kidney, effect of indometha- acetylmethadol (rats), 284 623 ancj of pain on fentanyl anal- cia (chimpanzee), 596 Enzymes, narcotic drug metabo- Fibrosis, pulmonary, bleomycin- gesia: Tolerance to and en- Diuretic, effects of vanadate on lizing, development in new- induced, evaluation of antifi- hancement of narcotic anal- isolated perfused kidney born rat, 28 brotic drugs in (hamsters), gesia, 418 (rat), 85 Epilepsy, in burned patients, de- 425 Contractile responses, to potas- Dobyan, D. C., Levi, J., Jacobs, creased phenytoin levels, 97 Flunixin, antinociceptive effects, sium and histamine in coro- C., Kosek, J. and Weiner, M. Epinephrine, -induced membrane blockade by l-lysine (rat), 445 nary artery smooth muscle, W.: Mechanism of cis-plati- potential changes in lacrimal Forde, J. H., see Chou, D. T., 580 effects of R02-2985 (pig), 59 sum nephrotoxicity: H. Mor- gland acinar cells (rats), 473 Fosset, M., see Romey, G., 607 Contrepois, A., see Carbon, C., 600 phologic observations, 551 Ergonovine maleate, -induced Free, C. A. and Hall, L E.: An- Corder, C. N., see Kumar, A., 85 Dopamine contractions of coronary ar- tiallergic properties of SQ Courtney, K. R.: Structure-activ- analogs, N-substituted, as ago- teries, inhibition by lidofla- 13,847, an orally effective ity relations for frequency- tiists of dopamine vascular zine (dog), 179 agent. II. Activity in vitro, dependent sodium channel receptors (dogs), 370 Ethacrynic acid, effects on sodium 437 block in nerve by local anes- effects of ring fluorination on transport and CO2 produc- Fujiwara, M., see Muramatsu, I., thetics, 114 cardiovascular actions of tion of bladders (toads), 383 156 Creveling, C. R., see Goldberg, L (dog), 509 Ethanol Furosemide I., 509 turnover in retina, enhance- circadian rhythms in biological effect on disposition of antibi- Cross-tolerance, between nitrous ment by barbituates of effects response and disposition of otics (rabbit), 600 oxide and alcohol (mice), 309 of muscimol on (rat), 332 (mouse), 1 effects on sodium transport and Cyclazocine ventilatory responses, effect of diet, effects on hepatic micro- CO2 production of bladders effects on discrimination of haloperidol (man), 13 somal drug metabolism, glu- (toads), 383 electric shock (monkeys), 234 Dopamine-j8-hydroxylase tamyl transferase and anti- effects on schedule-controlled alterations during experimental pyrine half-life (rats), 196 Gadeholt, G., Aarbakke, J., Dyb- behavior (rats), 497 diabetes (rats), 18 effects on neuronal activity in ing, E., Sj#{246}blom,M. and M#{248}r- Cyclic AMP, noradrenaline-in- gangliomc, increase after pre- somatosensory cortex (mon- land, J.: Hepatic microsomal duced accumulation in brain, ganglionic nerve stimulation, keys), 337 drug metabolism, glutamyl effect of lithium (rats), 161 role of mcotinic receptors effects on neurotransmitter re- transferase activity and in (rats), 139 ceptors (mice), 491 vivo antipyrine half-life in Dambach, G. E., see Pared, R. J., Doxepin, effect on cerebral capil- effects on testicular steroido- rats chronically fed an 473 lary permeability in vivo genesis (rats), 228 ethanol diet, a control diet Deimling, M. J. and Schnell, R. (rat), 313 inhibition ofmixed-function ox- and a chow diet, 196 C.: CirCadian rhythms in the Drug availability, during ethanol idation in liver (rats), 70 Gallant, E. M., Godt, R E. and biological response and dis- intoxication, studies with me- inhibition of synaptosomal cal- Gronert, G. A.: Mechanical position of ethanol in the phenytoin (dog), 173 cium uptake (rat, mice), 562 properties of normal and ma- mouse, 1 Dybing, E., see Gadeholt, G., 196 intoxication, drug availability lignant hyperthemia suscep- Desmethylimipramine, effect on during, studies with mephen- tible porcine muscle: Effects cerebral capillary permeabil- Ebstein, R P., Hermoni, M. and ytoin (dog), 173 ofhalothane and other drugs, ity in vivo (rat), 313 Belmaker, R H.: The effect withdrawal syndrome, suppres- 91 Diabetes, experimental, altera- of lithium on noradrenaline- sion by aliphatic diols (rats), Ganglion, superior cervical, in- tions in dopamine-/3-hydrox- induced cyclic AMP accu- 9 creased tyrosine hydroxylase ylase and norepinephrine mulation in rat brain: Inhibi- Ethoxzolamide, inhibition of bone and dopamine-$-hydroxylase (rats), 18 tion after chronic treatment resorption, lack of hypophos- after preganglionic nerve Dibenzazepines (see Tricyclic an- and absence of supersensitiv- phatemia (rats), 441 stimulation, role of nicotinic tidepressants) ity, 161 Ethylketocyclazocine, effects on receptors (rats), 139 Dibner, M. D., see Rabin, R. A., Eicosatrlenoic acid, effects on schedule-controlled behavior Garcia, A. G., see Kirpekar, S. M., 491 short-circuit current in iso- (rats), 497 133 Dickinson, R. G., Taylor, S. M., lated urinary bladder (toad), , effects on body tem- Gentamicin, disposition, effects Kaufman, S. N., Rodgers, R 462 perature (mice), 273 on furosemide (rabbit), 600 M., Lynn, R K., Gerber, N. Einspahr, F. J. and Piercey, M. F.: , effects on body tem- Gerber, J. G. and Nies, A. S.: The and Baughman, W. L: Non- Morphine depresses dorsal perature (mice), 273 role of prostaglandins in his- linear elimination and cho- horn neuron responses to Exocystosis, release of norepi- tamine-induced gastric yam- leretic effect of vaiproic acid controlled noxious and non- nephrine during nerve stim- dilation in the dog, 79 in the monkey, 38 noxious cutaneous stimula- ulation induced by RO 4- Gerber, N., see Dickinson, R. G., Diet, ethanol, effects on hepatic tion, 456 1284, effect ofparagyline pre- 38 microsomal drug metabolism, Electric shock treatment on (guinea pigs), Gilhis, C. N., see Catravas, J. D., glutamyl transferase and an- attenuated aversiveness during 534 120 tipyrine half-life (rats), 196 nitrous oxide analgesia (rat, Eye, amphetamine-induced my- Ginos, J. Z., see Kohli, J. D., 370 Digitoxin, effects on systolic arte- monkey), 128 driasis (cat), 49 Girl, S. N., see Zuckerman, J. E., Hal pressure and heart rate discrimination, effects of drugs 425 (rats), 520 (monkeys), 234 Fanelli, G. M., Jr., Bohn, D. L, Glutamyl transferase, hepatic, ef- Digoxigenin, positive isotropic ac- Electrophysiologic properties, of Camp, A. E. and Shum, W. fects ofethanolfeeding (rats), tion and sodium pump inhi- blood-superfused cardiac K.: Inability of indomethacin 196 bition, effects of sodium Purkinje fibers, effects of ye- to modify hydrochlorothia- Glutathione (guineapigs), 105 rapamil on (dogs), 222 zide diuresis and natrluresis depletion, effects on hepatic 2,4-Dimtrophenol, inhibition of Electrophysiological responses, by the chimpanzee kidney, glutathione turnover in vivo sodium transport and metab- enkephalin-induced, in cere- 596 (rats), 54 636 Index Vol. 213

turnover, hepatic, in vivo, de- -induced contractions in coro- effect on cerebral capillary lationships with beta adre- termination by acetamino- nary smooth muscle, effects permeability in vivo (rat), 313 noceptor blocking activity in phen probe analysis (rats), 54 of R02-2985 (pig), 59 effects on pulmonary clearance rabbits administered with dl- Godt, R E., see Gallant, E. M., 91 -induced gastric vasodilation, of[’4C]-5-hydroxytryptamine propranolol, 628 Goldberg, L. I., Kohli, J. D., Can- role of prostaglandins in and [3H]norepinephnine in Kenakin, T. P. and Beek, D.: Is tacuzene, D., Kirk, K. L and (dog), 79 vivo (rabbit), 120 prenalterol (H133/80) really Creveling, C. R: Effects of release from mast cells, inhibi- Indomethacin a selective beta-i adrenocep- ring fluorination on the car- tion by SQ 13,847 and SQ inability to modify hydrochlo- tor agonist? Tissue selectivity diovascul.ar actions of dopa- 12,903 (rats), 437 rothiazide diunesis and natri- resulting from differences in mine and norepinephrine in Hollingen, M. A., see Zuckerman, uresis by kidney (chimpan- stimulus-response relation- the dog, 509 J.E.,425 zee), 596 ships, 406 Goldberg, L. I., see Kohli, J. D., Hood, W. F., see Harris, R A., 562 placental clearance in near- Kepron, W., see Antonissen, L A., 370 Hosford, D. A. and Haigler, H. J.: term sheep, 100 150 Gronert, G. A., see Gallant, E. M., Morphine and methionine- Inturnisi, C. E., see Szeto, H. H., , effects on discnimina- 91 enkephalin: Different effects 346 tion of electric shock (mon- on spontaneous and evoked Inulin, renal tubular secretion by keys), 234 Haigler, H. J., see Hosford, D. A., neuronal firing in the meson- fetal lamb, 346 Ketocyclozocine, effects on sched- 355 cephalic reticular formation lonomycin, -induced catechola- ule-controlled behavior Hall, L. E., see Free, C. A., 437 of the rat, 355 mine secretion, 241 (cats), 497 Haloperidol, effect on ventilatory Hunt, W. A. and Majchrowicz, E.: lonophore Kidney responses to dopamine Suppression of the ethanol -induced catecholamine secre- clearance of[”C]allantoin (rab- (man), 13 withdrawal syndrome by ali- tion, 241 bit), 168 Halothane, -induced malignant phatic diols, 9 (R02-2985), effects on contnac- fetal lamb, tubular secretion of hyperthermia, properties of Hydralazine, -induced hypoten- tile responses to potassium mepenidine by, 346 muscle (pig), 91 sion, effect on actomyosin and histamine in coronary ar- inability of indomethacin to HalUshka, P. V., Levanho, A. and and mechanical properties of tery smooth muscle (pig), 59 modify hydrochlorothiazide Auber, M.: Arachidonic acid aorta (rats), 514 Ionio, L C., Latranyi, M., Heath, diuresis and natniuresis by stimulates short-circuit cur- Hydrochlorothiazide, renal clear- E. and Bassett, A.: Blockade (chimpanzee), 596 rent in the isolated toad un- ance, effect of indomethacin by l-lysine of non-narcotic isolated peifused, diuretic and nary bladder, 462 (chimpanzee), 596 analgesics, 445 vasoconstnictor effects of Harris, R A.: Interactions be- , effects on body Ishikawa, H., see Kawashima, K., vanadate (rat), 85 tween narcotic agonists, par- temperature (mice), 273 628 toxicity of cia-platinum (rat), tial agonists and antagonists p-Hydroxyamphetamine, metab- Isoniazid, hepatotoxicity, rela- 545, 551 evaluated by schedule-con- olite of amphetamine, effect tionship to metabolism in uptake and acetylation of p- trolled behavior, 497 on blood pressure and heart vivo (rats), 364 aminohippurate by (mice), Harris, R A. and Hood, W. F.: rate (rats), 504 Isoproterenol 350 Inhibition of synaptosomal p-Hydroxynorephedrine, metabo- effects on taurmne in tissues vanadate inhibition of renin so- calcium uptake by ethanol, lite of amphetamine, effect (rat), 399 cretion from (rat), 144 562 on blood pressure and heart -stimulated renin secretion Kirk, K. L., see Goldberg, L. I., Hayashi, K., see Muramatsu, I., rate (rats), 504 from kidney, inhibition by 509 156 3-Hydroxyquinidine, pharmaco- vanadate (rat), 144 Kirpekar, S. M., Garcia, A. G. and Head, R., see Berkowitz, B. A., 18 kinetics, phenytoin-Induced Prat, J. C.: Action of nicotine Heart changes (dogs), 33 Jacobs, C., see Dobyan, D. C., 551 on sympathetic nerve termi- cells, chick embryonic, in cul- 5-Hydroxytryptamine, -induced Jacobs, C., see Levi, J., 545 nals, 133 tune, interaction with sea contractions of coronary as- Jaillon, P. and Kates, R. E.: Kohli, J. D., see Goldberg, L. I., anemone polypeptide toxin, tenies, inhibition by lidofla- Phenytoin-induced changes 509 607 sine (dog), 179 in and 3-hy- Kohli, J. D., Weber, A. B., Gold- Purkinje fibers, blood-super- [‘4C]-5-Hydroxytryptamine, pul- droxyquinidine pharmacoki- berg, L. I. and Ginos, J. Z.: fused, effects of verapamil on monary clearance in vivo, ef- netics in conscious dogs, 33 Structure activity relation- electrophysiologic properties fects of imipramine or co- Janssen, P. A. J., see Colpaert, F. ships N-substituted dopa- of (dogs), 222 caine (rabbit), 120 C., 418 mine derivatives as agonists Heart rate Hyman, A. L and Kadowitz, P. J.: Job, T., see Berkowitz, B. A., 18 ofthe dopamine vascular and effects of cardiac glycosides Vasodilator actions of pro- Johnson, J. H. and Rosecrans, J. other cardiovascular recep- (rats), 520 staglandin 6-keto-E1 in the A.: Blockade of ovulation by tons, 370 effect of p-hydroxyampheta- pulmonary vascular bed, 468 methadone in the rat: A cen- Kosek, J., see Dobyan, D. C., 551 mine and p-hydroxynore- Hyperthermia, malignant, in- tral nervous system-me- Koss, M. C.: Studies on the mech- phednine (rats), 504 duced by halothane and diated acute effect, 110 arnsm of amphetamine my- Heath, E., see Ionio, L C., 445 other drugs, properties of driasis in the cat, 49 Heimbach, D. M., see Bowdie, T. muscle (pig), 91 Kadowitz, P. J., see Hyman, A. L., Knebs, H. A., see Yeh, S. Y., 28 A., 97 Hypotension, hydralazine-in- 468 Kroeger, E. A., see Antonissen, L Heistad, D. D., see Bainbrldge, C. duced, effect on actomyosin Kalman, S. M., see Levi, J., 545 A., 150 W., 13 and mechanical properties of Karaki, H. and Weiss, G. B.: Ef- Kumar, A. and Corder, C. N.: Di- Hemostasis aorta (rats), 514 fects ofstimulatory agents on uretic and vasoconstnictor ef- changes after rattlesnake mobilization of high and low fects of sodium orthovana- venom (dog), 414 ileum, role of calcium in affinity site Ca in rabbit aor- date on the isolated perfused Hempstead, J., see Berkowitz, B. action in (guinea pig), 188 tic smooth muscle, 450 rat kidney, 85 A., 18 Imidazolines Karczmar, A. G., see Akasu, T., Hermoni, M., see Ebstein, R P., receptor interactions, differen- 586 Lacrimal gland, acinar cells, mem- 161 tiation of postsynaptic alpha Kates, R. E., see Jaillon, P., 33 brane potential changes in- Hirsh, K. R., see Chou, D. T., 580 adrenergic receptors by don- Kauffman, F. C., see Reinke, L duced by carbachol and epi- Histamine idine (rat), 557 A., 70 nephrine (rats), 473 effects in airway smooth muscle receptor interactions, effects of Kaufman, S. N., see Dickinson, R Lamotte-Barnillon, S., see Car- in asthma (dog), 150 clonidine analogs on alpha G., 38 bon, C., 600 effects on high and low affinity adrenergic receptors in aorta Kawashima, K. and Ishikawa, H.: Langley, A. E. and Weiner, N.: binding of Ca in aortic (rat), 267 Pharmacokinetics of pro- The effect of pargyline pre- smooth muscle (rabbit), 450 Imipramine pranolol isomers and their re- treatment on the enhance- 1980 Index 637

ment of the exocytotic re- nephnine in vivo, effects of Metabolites, amphetamine, role halothane and other drugs, 91 lease of norepinephrine dun- Imipramine or cocaine (nab- in acute responses to d-am- smooth, airway, asthma, hista- ing nerve stimulation which bit), 120 phetamine (rats), 504 mine effects (dog), 150 is induced by a benzoquinol- vascular bed, effects of throm- Methacholine, comparison with smooth, aortic, effects of nor- izine compound with rosen- boxane B2 on (cats, dogs), 300 oxytocin in effect on prosta- epinephnine and potassium pine-like properties, 534 vascular bed, vasodilator ac- glandin release in isolated on high and low affinity bind- Larrow, R W., see Szeto, H. H., tions ofprostaglandin 6-keto- uterus (rat), 575 ing of Ca (rabbit), 450 346 E1in (cats), 468 Methadone smooth, coronary arterial, con- Larson, D. L, see Caruso, T. P., Lupus erythematosus, A/J mice blockade of ovulation by, role tractile responses to potas- 539 as genetic model for, 480, 485 of central nervous system slum and histamine, effects of Lasalocid, -induced catechola- Luteinizing hormone secretion, (rat), 110 R02-2985 (pig), 59 mine secretion, 241 inhibition by z9-tetnahydro- effects on body temperature Mydniasis, amphetamine-induced Latranyi, M., see Ionio, L C., 445 cannabinol (rats), 306 (mice), 273 (cat), 49 Lauterburg, B. H., Vaishnav, Y., Lymphocytes, in vitro acetamin- effects on discrimination of myo-Inositol 1-phosphate, in cere- Stillwell, W. G. and Mitchell, ophen toxicity in (man), 395 electric shock (monkeys), 234 bral cortex, depression by al- J. R.: The effect of age and Lynn, R K., see Dickinson, R G., -induced attenuation of effects cobol (rat), 24 glutathione depletion on he- 38 of 9-tetrahydrocannabinol patic glutathione turnover in l-Lysine, blockade of non-narcotic on temporal discrimination , effects on discrimi- vivo determined by acet- analgesics (rats), 445 (pigeons), 247 nation ofelectnic shock (mon- aminophen probe analysis, 54 Methazolamide keys), 234 Lazdunski, M., see Homey, G., 607 Maderdrut, J. L., see Ramana inhibition of bone resorption, , effects on discnimina- Lee, C.-Y., see Muramatsu, I., 156 Reddy, S. V., 525 lack of hypophosphatemia tion of electric shock (mon- Levanho, A., see Halushka, P. V., Majchrowicz, E., see Hunt, W. A., (rats), 441 keys), 234 462 9 inhibition of carbonic anhy- , seminal excretion, Levi, J., Jacobs, C., Kalman, S. Mandell, A. J., Bullard, W. P., drase, relation to cerebrospi- plasma elimination, tissue M., McTigue, M. and Weiner, Yellin, J. B. and Russo, P. V.: nal fluid (cats), 321 distribution and metabolism M. W.: Mechanism of cia- The influence of D-amphet- Methionine-enkephalin, and mor- of (rabbits), 289 platinum nephrotoxicity: I. amine on rat brain striatal- phine, effects on neurons.! fir- (see also specific drug) Effects of sulihydryl groups reduced biopterin concentna- ing in brain (rats), 355 analgesia, tolerance to and en- in rat kidneys, 545 tion, 569 Methoxamine, effects on taunine hancement of (rats), 418 Levi, J., see Dobyan, D. C., 551 Mann, L I., see Szeto, H. H., 346 in tissues (rat), 399 metabolizing enzymes, devel- , effects on body tem- Maroli, A. N., see Colpaert, F. C., 1-Methyl-3-isobutyl xanthine, ef- opment in newborn rat, 28 perature (mice), 273 418 fects on neuromyal transmis- Natniuresis, hydrochiorothiazide, Levy, R H., see Bowdie, T. A., 97 Marretta, J., see Casey, F. B., 432 sion (frog), 586 kidney, effect of indometha- Lidoflazine, inhibition of contrac- Mason, S. T., see Bininger, R J., Mitchell, J. R, see Lauterburg, B. din (chimpanzee), 596 tions of coronary arteries 623 H., 54 Neal, G. D., see Bowdie, T. A., 97 caused by norepinephnine, 5- McTigue, M., see Levi, J., 545 Mitchell, J. R, see Timbrell, J. A., Nelson, S. D., see Timbrell, J. A., hydroxytryptamine, potas- Melchior, C., see Rabin, R. A., 491 364 364 slum, anoxia and ergonovine Membrane potential, in lacrimal Mitchell, R. W., see Antonissen, Nephrotoxicity, of cia-platinum maleate (dog), 179 gland acinar cells, changes in- L A., 150 (rat), 545, 551 Lineberry, M. C., see Waite, L C., duced by carbachol and epi- Miura, A., see Muramatsu, I., 156 Nerve 441 nephnine (rat), 473 Molinoff, P. B., see Rabin, R A., myelinated, frequency-depen- Lithium, effect on noradrenaline- Meperidine 491 dent sodium channel block induced cyclic AMP accu- effects on body temperature Monensin, -induced catechola- by local anesthetics (frog), mulation in brain (rats), 161 (mice), 273 mine secretion, 241 114 Liver renal tubular secretion by fetal M#{248}rland,J., see Gadeholt, G., 196 parasympathetic (vagus), choleretic effect of vaiproic acid lamb, 346 Morphine blockade by /1-bungarotoxin (monkey), 38 Mephenytoin, model of drug action in ileum, role of calcium (guinea pig), 156 glutathione turnover in vivo, availability during ethanol (guinea pig), 188 sympathetic, terminals, action determination by acetamino- intoxication (dog), 173 and methione-enkephalin, ef- of nicotine and 4-aminopyni- phen probe analysis (rats), 54 Metabolism fects on neuronal firing in dine on (cat), 133 inhibition ofmixed-function ox- and sodium transport of blad- brain (rats), 355 Nerve stimulation, preganglionic, idation by ethanol in (rats), ders, effects of furosemide effects on body temperature increased ganglionic tyrosine 70 and ethacrynic acid (toads), (mice), 273 hydroxylase and dopamine- microsomal drug metabolism, 383 effects on discrimination of -hydroxylase after, role of glutamyl transferase and an- and sodium transport of blad- electric shock (monkeys), 234 nicotinic receptors (rats), 139 tipynine half-life, effects of ders, effects of metabolic and effects on responses of spinal Nervous system ethanol feeding (rats), 196 transport inhibitors (toads), neurons to cutaneous stimu- central, amphetamine-induced newborn rat, development of 375 lation (cats), 456 mydriasis caused by (cat), 49 narcotic drug metabolizing and sodium transport of blad- effects on schedule-controlled central, role in blockade of ovu- enzymes, 28 ders, effects of sodium and behavior (rats), 497 lation by methadone (rat), toxic effects of isoniazid, rela- potassium (toads), 390 -induced analgesia, effects of 1- 110 tionship to metabolism in ethanol, interaction with lysine (rats), 445 Neuroleptic, -induced avoidance vivo (rats), 364 mixed-function oxidation in Mudge, G. H., see Carpenter, H. training, evaluation by con- Local anesthetics (see Anes- liver (rats), 70 M.,350 ditioned suppression (rat), thetics, local) hepatic microsomal drug, ef- Munamatsu, I., Fujiwara, M., 623 Lombardini, J. B.: Effects of iso- fects ofethanolfeeding (rats), Miura, A., Hayashi, K. and Neurons proterenol and methoxamine 196 Lee, C.-Y.: /3-Bungarotoxin activity in somatosensory cor- on the contents of taurine in in vivo ofisoniazid, relationship and parasympathetic nerve tex, effects of pentobarbital rat tissues, 399 to hepatotoxicity (rats), 364 blocking action, 156 and ethanol (monkeys), 337 Lung ofethanol, circadian rhythms in Muscimol, effects on dopamine dorsal horn, effects of morphine bleomycin-induced fibrosis, ef- (mouse), 1 turnover in retina, enhanced on responses to cutaneous fects of antifibrotic drugs of naltrexone (rabbits), 289 by barbiturates (rat), 332 stimulation (cats), 456 (hamsters), 425 serotonin, brain, effects of sub- Muscle in mesencephalic reticular for- clearance of [‘4C]-5-hydroxy- stituted phenylethylamines porcine, properties in malignant mation, effects of morphine tryptamine and [3H}norepi- (mice), 254 hyperthermia induced by and methionine-enkephalin 638 Index Vol. 213

on firing (rats), 355 sure and heart rate (rats), 520 acetylator, relationship of an- bladder, effects of arachi- medial thalamic, effect of cal- Inhibition of renin secretion tinuclear antibodies to domc and eicosatnienoic acids feine and amphetamine (rat), from kidney (rat), 144 (mice), 485 (toad), 462 580 inhibition of sodium transport Phernetton, T. M., see Anderson, Protriptyline, effect on cerebral Neuromyal transmission, effects and metabolism (toads), 375 D.F., 100 capillary permeability in vivo of l-methyl-3-isobutyl xan- Ovulation, blockade by metha- Phillips, A. G., see Beninger, R. (rat), 313 thine (frog), 586 done, role of central nervous J., 623 Punkinje fibers, cardiac, blood-su- Neurotnansmitter, receptors, ef- system (rat), 110 Phosphate, concentrations after perfused, effects of verapamil fects ofethanol on (mice), 491 , effects on body sulfonamide inhibition of on electrophysiologic prop- Nicotine and 4-aminopynidine, ac- temperature (mice), 273 bone resorption (rat), 441 erties of (dogs), 222 tion on sympathetic nerve Oxytocin, effect on prostaglandin Pierce, W. M., Jr., see Waite, L. Putney, J. W., Jr., see Parod, R. terminals (cat), 133 release in isolated uterus, C., 441 J., 473 Niemegeers, C. J. E., see Colpaert, comparison with angiotensin Piercey, M. F., see Einspahn, F. J., F. C., 418 and methacholine (rat), 575 456 Quinidine, phanmacokinetics, Nies, A. S., see Gerber, J. G., 79 , effect on avoidance re- phenytoin-induced changes p-Nitroanisole, 0-demethylation, Pain, and prior administration, ef- sponse (rat), 623 (dogs), 33 inhibition in liver by ethanol fect on fentanyl analgesia Placental, clearance, of indometh- (rats), 70 (rat), 418 acin in near-term sheep, 100 Rabin, R A., Wolfe, B. B., Dibner, Nitrous oxide Pargyline, pretreatment, effect on Plasma M. D., Zahniser, N. R, Mel- analgesia, attenuated aversive- exocytotic release of norepi- elimination, of naltrexone (rab- chior, C. and Molinoff, P. B.: ness of electric shock during nephnine during nerve stim- bits), 289 Effects of ethanol adminis- (rat, monkey), 128 ulation induced by R04-1284 protein binding of phenytoin in tration and withdrawal on tolerance to (mice), 309 (guinea pigs), 534 burns (rats, man), 97 neurotransmitter receptor Non-narcotic analgesics, blockade Parod, R J., Dambach, G. E. and Portoghese, P. S., see Caruso, T. systems in C57 mice, 491 by l-lysine (rats), 445 Putney, J. W., Jr.: Membrane P., 539 Ramana Reddy, S. V., Maderdrut, Noradrenaline (see also Norepi- potential changes in lacnimal Potassium J. L and Yaksh, T. L: Spinal nephnine) gland acinar cells elicited by effects on high and low affinity cord pharmacology of adre- -induced cyclic AMP accumu- carbachol and epinephnine, binding of Ca in aortic nergic agonist-mediated an- lation in brain, effect of lith- 473 smooth muscle (rabbit), 450 tinociception, 525 ium (rats), 161 D-Penldlllamme, effects on bleo- effects on metabolism and so- Ra.nkin, J. H. G., see Anderson, Norepinephnine ( see also Nor- mycin-induced pulmonary fi- dium transport of bladders D. F., 100 adrenaline) brosis (hamsters), 425 (toads), 390 Rattlesnake venom, hemostatic alterations during experimental Pent.azocine, effects on discrimi- -induced contractions of coro- changes after (dogs), 414 diabetes (rats), 18 nation ofelectric shock (mon- nary arteries, inhibition by li- Receptors effects on high and low affinity keys), 234 doflazine (dog), 179 adrenergic (see Adrenergic re- binding of Ca in aortic Pentobarbital -induced contractions in coro- ceptors) smooth muscle (rabbit), 450 effects on neunonal activity in nary smooth muscle, effects alpha adrenengic, postsynaptic, effects of ring fluorination on somatosensory cortex (mon- ofRO2-2985 (pig), 59 differentiation by clonidine cardiovascular actions of keys), 337 Powell, J. R.: Increased total and (rat), 557 (dog), 509 effect on synaptosomal calcium regional vascular resistance alpha and mucarinic, prejunc- exocytotic release during nerve uptake (rat, mice), 562 produced by propranolol, 64 tional, interaction with ami- stimulation induced by R04- enhancement of effects of mus- Prat, J. C., see Kirpekar, S. M., triptyline in saphenous vein 1284, effect of pargyline pre- cimol on dopamine turnover 133 (dog), 616 treatment (guinea pigs), 534 in retina (rat), 332 Preisig, R., see Zysset, T., 173 dopaminergic, blockade by -induced contractions of coro- Pharmacokinetics (see also Ki- Prenalterol, beta-i adrenoceptor halopenidol, effect on venti- nary arteries, Inhibition by li- netics) agonist, tissue selectivity lation (man), 13 doflazine (dog), 179 of naltrexone (rabbits), 289 (cats), 406 histamine, interaction with -mediated antinociception, spi- of dl- and l-propranolol, rela- Procainamide, induction of anti- prostaglandins in histamine- nal cord pharmacology of tionship with beta adreno- nuclear antibodies by, related induced gastric vasodilation (rats), 525 ceptor blocking activity (rab- to acetylator phenotype (dog), 79 release from saphenous vein, bit), 628 (mice), 485 neurotnansmitter, effects of effect of amitniptyline (dog), of quinidine and 3-hy- Propoxyphene, effects on discnim- ethanol on (mice), 491 616 droxyquinidine, phenytoin- ination of electric shock nicotinic, role in increased gas- release from sympathetic nerve induced changes (dogs), 33 (monkeys), 234 gliomc tyrosine hydroxylase terminals, effects of nicotine phenytoin, in burns (rats, man), Propranolol, increased vascular and dopamine-$-hydroxylase and 4-aminopynidine (cat), 97 resistance (dogs), 64 after preganglionic nerve 133 Phenobarbital, enhancement of dl- and 1-Propranolol, pharmaco- stimulation (rats), 139 [3H]Norepinephrine, pulmonary effects of muscimol on dopa- kinetics, relationship with , in mesencephalic retic- clearance in vivo, effects of mine turnover in retina (rat), beta adrenoceptor blocking ular formation (rats), 355 imipramine or cocaine (nab- 332 activity (rabbit), 628 vascular, dopamine, N-substi- bit), 120 Phenylbutazone, antinociceptive Prostacyclin, chronotnopic effects, tuted dopamine analogs as Nortniptyline, effect on cerebral effects, blockage by l-lysine comparison with prostaglan- agonists of (dogs), 370 capillary permeability in vivo (rat), 445 din E2 (dog), 261 Reinke, L A., Kauffman, F. C., (rat), 313 Phenylethylamines, substituted, Prostaglandin Belinsky, S. A. and Thurman, effects on brain serotonin me- B2, chronotropic effects, com- R. G.: Interactions between , effects on body temper- tabolism (mice), 254 parison with prostacyclin ethanol metabolism and atune (mice), 273 Phenytoin (dog), 261 mixed-function oxidation in Opioid, action in ileum, role of -induced changes in quinidine 6-keto-E,, vasodilator actions in perfused rat liver. Inhibition calcium (guinea pig), 188 and 3-hydroxyquinidine pulmonary vascular bed of p-nitroanisole 0-demeth- Opmeer, F. A. and Van Rae, J. pharmacokinetics (dogs), 33 (cats), 468 ylation, 70 M.: Differential involvement pharmacokinetics and plasma -releasing action in isolated Renaud, J. F., see Homey, G., 607 of calcium in acute and protein binding in burns uterus, effect of oxytocin Resin, secretion from kidney, in- chronic opiold action in the (rats, man), 97 (rat), 575 hibition by vanadate (rat), guinea-pig ileum in vitro, 188 Phenotype role in histamine-induced gas- 144 Ouabain acetylator, inheritance of tric vasodilation (dog), 79 Retina, dopamine turnover, en- effects on systolic arterial pres- (mice), 480 synthesis in isolated urinary hancement by barbiturates of 1980 Index 639

effects of muscimol on (rat), and heart rate responses morphine on responses of chick embryonic cardiac 332 evoked byp-hydroxyamphet- spinal neurons to (cats), 456 cells, 607 Rice, P. J., see Chalazonitis, A., amine and by p-hydroxy- Stomach, histamine-induced Trachea, smooth muscle, asthma, 139 norephedrine H. A quantita- vasodilation, role of prosta- histamine effects (dog), 150 R02-2985, effects on contractile tive assessment of the role of glandins in (dog), 79 Transmission, neuromyal, effects responses to potassium and amphetamine metabolites in Streptozotocin, -induced diabetes, of 1-methyl-3-isobutyl xan- histamine in coronary acute responses evoked by d- alterations in dopamine-fl- thine on (frog), 586 smooth muscle (pig), 59 amphetamine, 504 hydroxylase and norepineph- Tricycic antidepressants (diben- R04-1284, -induced exocytotic Sj#{246}blom,M., see Gadeholt, G., 196 nine (rats), 18 zazepines), effect on cerebral release of norepinephnine SKF-10,047, effects on schedule- Succinylcholine, -induced malig- capillary permeability in vivo during nerve stimulation, ef- controlled behavior (rats), nant hyperthermia, proper- (rat), 313 fect of pargyline pretreat- 497 ties of muscle (pig), 91 Tyrosine hydroxylase, ganglionic, ment (guinea pigs), 534 Smooth muscle (see Muscle, Sulfonamide, inhibition of bone increase after preganglionic Roch-Ramel, F., see Sch#{228}li,C., smooth) resorption, lack of hypophos- nerve stimulation, role of mc- 168 Snodgrass, W. R., see Timbrell, J. phatemia (rats), 441 otinic receptors (rats), 139 Rodgers, R. M., see Dickinson, R. A., 364 Sympathetic nerve (see Nerve, G., 38 Sodium sympathetic) Uptake Homey, G., Renaud, J. F., Fosset, -dependent choline uptake, Synaptosomes, brain, calcium up- p-aminohippurate, by kidney M. and Lazdunski, M.: Phar- brain, effects of 9-tetrahy- take, inhibition by ethanol (mice), 350 macological properties of the drocannabinol and cannabi- (rat, mice), 562 choline, sodium-dependent, interaction of a sea anemone diol (rats), 216 Szeto, H. H., Clapp, J. F., III, Las- brain, effects of z9-tetrahy- polypeptide toxin with car- effects on metabolism and so- row, R W., Inturnisi, C. E. drocannabinol and cannabi- cliac cells in culture, 607 dium transport of bladders and Mann, L I.: Renal tubu- diol (rats), 216 Roppolo, J. R, see Collins, J. G., (toads), 390 lax secretion ofmepenidine by synaptosomal calcium, inhibi- 337 effects on positive inotropic ac- the fetal lamb, 346 tion by ethanol (rat, mice), Rosecrans, J. A., see Johnson, J. tion and of digoxigenin so- 562 H., 110 dium pump inhibition Takemori, A. E., see Caruso, T. Uterus, isOlated, effect of oxytocin Rotenone, inhibition of sodium (guinea pigs), 105 P., 539 on prostaglandin release in transport and metabolism transport and CO2 production Tannen, R H. and Weber, W. W.: (rat), 575 (toads), 375 of bladders, effects of furose- Antinuclear antibodies re- Ruffolo, R. R., Jr., Yaden, E. L mide and ethacrynic acid lated to acetylator phenotype Vaishnav, Y., see Lauterburg, B. and Waddell, J. E.: Receptor (toads), 383 in mice, 485 H., 54 interactions of imidazolines. transport and CO2 production Tannen, R H. and Weber, W. W.: Valproic acid, elimination and V. Clomdine differentiates of bladders, effects of mets- Inheritance of acetylator choleretic effect (monkey), 38 postsynaptic alpha adrener- bolic and transport inhibitors phenotype in mice, 480 Vanadate gic receptor subtypes in tis- (toads), 375 Taurine, in tissues, effects of iso- diuretic and vasoconstrictor ef- sues from the rat, 557 Sodium channel block, frequency- proterenol and methoxamine fects on isolated perfused kid- Ruiz, C. E., Schaeffer, R. C., Jr., dependent, in nerve by local on (rat), 399 ney (rat), 85 Weil, M. H. and Carbon, R anesthetics (frog), 114 Taylor, S. M., see Dickinson, R. inhibition of remn secretion W.: Hemostatic changes fol- Sodium pump, inhibition by di- G., 38 from kidney (rat), 144 lowing rattlesnake (Crotalus goxigenin, effects of sodium Temperature, body, effects of opi- Van Beek, J., see Van Nueten, 179 viridis helleri) venom in the (guinea pigs), 105 atm on (mice), 273 Vanhoutte, P. M., see Van Nue- dog, 414 Sodium transport, and metabo- Testes, steroidogenesis, effects of ten,J.M., 179 Russo, P. V., see Mandell, A. J., lism ofbladders, effects of so- ethanol and acetaldehyde Van Nueten, J. M., Van Beak, J. 569 dium and potassium (toads), (rats), 228 and Vanhoutte, P. M.: Inhib- 390 i9-Tetrahydrocannabinol itory effect of lidoflazine on Schaeffer, R. C., Jr., see Ruiz, C. Somatosensory cortex, effects of effects on sodium-dependent contractions of IsOlated ca- E., 414 pentobarbital and ethanol on choline uptake in brain (rats), nine coronary arteries caused Sch#{228}li, C. and Roch-Ramel, F.: neuronal activity in (mon- 216 by norepinephrine, 5-hy- Renal handling of [‘4C]allan- keys), 337 effects on temporal discnimina- droxytryptamine, high potas- toin in the rabbit, 168 Spielberg, S. P.: Acetaminophen tion, methadone-induced at- slum, anoxia and ergonovine Schnell, R. C., see Deimling, M. toxicity in human lympho- tenuation of (pigeons), 247 maleate, 179 J., 1 cytes in vitro, 395 inhibition of luteinizing hor- Van Rae, J. M., see Opmeer, F. Schwartz, A., see Berner, P. F., 59 Spinal cord, pharmacology of a1 mone secretion (rats), 306 A., 188 , effects on discnimi- p1w agonists-mediated anti- Thalamus, medial, unit activity, Vascular bed, pulmonary, effects nation ofelectric shock (mon- nociception (rats), 525 effects of caffeine and am- of thromboxane B on (cats, keys), 234 SQ 12,903 phetamine (rat), 580 dogs), 300 Seidel, C. L, Allen, J. C. and Bow- analog of SQ 13,847, activity in Thnomboxane B2, effects on pul- Vascular resistance, increased by ers, R L.: Mechanical and vitro (rats), 437 monary vascular bed (cats, propranolol (dogs), 64 biochemical alteration of analog of SQ 13,847, activity in dogs), 300 Vasoconstnictor effects of throm- aorta induced by hydralazine vivo (rats, mice, guinea pigs), Thurman, R. G., see Reinke, L. boxane B2 in pulmonary vas- hypotension, 514 432 A., 70 cular bed (cats, dogs), 300 Semen, excretion, of naltrexone SQ 13,847 Timbrell, J. A., Mitchell, J. R., of vanadate on isolated per- (rabbits), 289 antiallergic properties, in vitro Snodgrass, W. R and Nelson, fused kidney (rat), 85 Serotonin, metabolism, brain, ef- activity (rats), 437 S. D.: Isoniazid hepatotoxic- Vasodilation, gastric, histamine- fects of substituted phenyl- antiallergic properties, in vivo ity: The relationship between induced, role of prostaglan- ethylamines (mice), 254 activity (rats, mice, guinea covalent binding and metab- dma in (dog), 79 Shepherd, J. T., see Collis, M. G., pigs), 432 olism in vivo, 364 Vasodilator actions, of prosta- 616 Stephens, N. L, see Antonissen, Tissue distribution, of naltrexone glandin 6-keto-E1 in pulmo- Short-circuit current, in isolated L A., 150 (rabbits), 289 nary vascular bed (cats), 468 urinary bladder, effects of as- Steroidogenesis, testicular, effects Toxicity Vein, saphenous, interaction of achidomc and eicotrienoic of ethanol and acetaldehyde hepatic, isoniazed (rats), 364 amitniptyline with prejunc- acids (toad), 462 (rats), 228 of acetaminophen in lympho- tional alpha and muscaninic Shum, W. K., see Fanelli, G. M., Stillwell, W. G., see Lauterburg, cytes in vitro (man), 395 receptors (dog), 616 Jr., 596 B. H., 54 Toxin, sea anemone polypeptide, Ventilatory responses, to dopa- Simpson, L L: Blood pressure Stimulation, cutaneous, effects of interaction with cultured mine, effect of haloperidol 640 Index Vol. 213

(man), 13 Weiner, M. W.: Effects of furose- ofan uncoupling agent to dma- influx, 105 Verapamil, effects on electrophys- mide and ethacrynic acid on tinguish between effects on Yeh, S. Y. and Krebs, H. A.: De- iologic properties of bbood-su- sodium transport and CO2 transport and metabolism, vebopment of narcotic drug perfused cardiac Purkinje fi- production of toad bladders: 375 metabolizing enzymes in the bars (dogs), 222 Evidence for direct inhibition Withdrawal syndrome, ethanol, newborn rat, 28 Vigneron, A.-M., see Carbon, C., of active transport, 383 suppression by aliphatic diols Yellin, J. B., see Mandell, A. J., 600 Weiner, M. W.: Effects of sodium (rats), 9 569 and potassium on energy me- Wolfe, B. B., see Rabin, R A., 491 WaddeR, J. E., see Ruffobo, R R, tabolism and sodium trans- Wood, R W., Warren, P. H. and Zahniser, N. R, see Rabin, R A., Jr., 557 port of toad bladders, 390 Weiss, B.: Attenuated aver- 491 Waite, L C., Pierce, W. M., Jr. Weiner, M. W., see Dobyan, D. siveness of electric shock dun- Zigmond, R. E., see Chalazomtis, and Lineberry, M. C.: SiMon- C., 551 ing nitrous oxide exposure, A., 139 amide inhibition of bone re- Weiner, M. W., see Levi, J., 545 128 Zuckerman, J. E., Hollinger, M. sorption: Lack ofa hypophos- Weiner, M. W., see Winder, C. L, A. and Girl, S. N.: Evaluation phatemia, 441 375 Yaden, E. L, see Ruffobo, R R, of antifibrotic drugs in bleo- Warren, P. H., see Wood, R W., Weiner, N., see Langley, A. E., 534 Jr., 557 mycin-induced pulmonary fi- 128 Weiss, B., see Wood, H. W., 128 Yaksh, T. L, see Ramana Reddy, brosis in hamsters, 425 Weber, W. W., see Tannen, R. H., Weiss, G. B., see Karaki, H., 450 S. V., 525 Zysset, T., Preisig, R and Bircher, 480 Winder, C. L and Weiner, M. W.: Yamamoto, S., Akena, T. and J.: Increased systemic avail- Weber, W. W., see Tannen, R H., Effects of metabolic and Brody, T. M.: Positive ino- ability of drugs during acute 485 transport inhibitors on so- tropic action of digoxigenin ethanol intoxication: Studies Weder, A. B., see Kohli, J. D., 370 dium transport and CO2 pro- and sodium pump inhibition: with mephenytoin in the dog, Weil, M. H., see Ruiz, C. E., 414 duction of toad bladders: Use Effects of enhanced sodium 173