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WO 2016/110872 Al 14 July 2016 (14.07.2016) P O P C T

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WO 2016/110872 Al 14 July 2016 (14.07.2016) P O P C T (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2016/110872 Al 14 July 2016 (14.07.2016) P O P C T (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 8/97 (2006.01) A61Q 19/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, PCT/IN20 16/0000 12 KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (22) International Filing Date: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 8 January 2016 (08.01 .2016) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (25) Filing Language: English TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 72/MUM/20 15 8 January 20 15 (08.0 1.20 15) IN GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: ZYDUS WELLNESS LIMITED [IN/IN]; TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, House No. 6 & 7, Sigma Commerce Zone, Sarkhej-gandh- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, inagar Highway, Ahmedabad - 380015, Gujarat (IN). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: DATTA, Hema Sharma; House No. 6 & 7, GW, KM, ML, MR, NE, SN, TD, TG). Sigma Commerce Zone, Sarkhej-gandhinagar Highway, Ahmedabad - 380015, Gujarat (IN). Declarations under Rule 4.17 : CHANDRAKANTBHAI, Mehta Arti; House No. 6 & 7, — as to applicant's entitlement to apply for and be granted a Sigma Commerce Zone, Sarkhej-gandhinagar Highway, patent (Rule 4.1 7(H)) Ahmedabad - 380015, Gujarat (IN). Published: (74) Agents: SUBRAMANIAM, Hariharan et al; Sub- ramaniam & Associates, Central Square, Suite-328, Plaza — with international search report (Art. 21(3)) III, 20 Manoharlal Khurana Marg, Bara Hindu Rao (off — before the expiration of the time limit for amending the Rani Jhansi Road), Delhi- 110006 (IN). claims and to be republished in the event of receipt of (81) Designated States (unless otherwise indicated, for every amendments (Rule 48.2(h)) kind of national protection available): AE, AG, AL, AM, o00 o (54) Title: FOOT CARE COMPOSITIONS (57) Abstract: The present invention relates to new foot care compositions, the oily phase of which comprises extracts of at least five different plants wherein at least one plant extract is selected from the group comprising buchanania lanzan extract, cassia tora extract, pongamia glabra extract, shorea robusta extract. The invention also relates to compositions comprising such plant extracts and process for preparing these compositions. FOOT CARE COMPOSITIONS Field of invention The present invention relates to new foot care compositions, the oily phase of which comprises extracts of at least five different plants wherein at least one plant extract is selected from the group comprising buchanania lanzan extract, cassia tora extract, pongamia glabra extract, shorea robusta extract. The invention also relates to compositions comprising such plant extracts and process for preparing these compositions. Background of the invention Human skin consists of two major layers, a relatively thicker layer called dermis and a superficial layer called epidermis. The skin serves both to keep out noxious material, disease producing organisms and to keep in valuable commodities such as water. Under normal conditions of average humidity, water is lost continuously from the surface of the skin. At a very high humidity, the skin is almost water-logged, but at a very low relative humidity, the rate of loss from the skin will exceed the rate of passage from body tissue. Water content in the horny layer of the skin falls below the level required to maintain its palacity and its flexibility becomes less than that of normal skin. Changes of this nature occur at low humidity resulting in cracks of heels and sometimes in hands. Cracked heels are a common problem that may develop into painful fissures or openings if left untreated. The cracks are abnormalities in the skin resulting in pain, bleeding, sensitivity to cold and warmth. You may see dehydrated feet as a minor nuisance; however it can lead to further problems such as fungal infections and ulcerations. Foot care is an especially important issue for the increasing number of diabetic patients globally. Cracks in heels may be superficial, deep and very deep. The other cause of cracks in heels can be due to unknown pathological reasons and frequent exposure to detergents and dust. Skin loses its ability to stretch with age, so cracks are more common as you get older. Diabetes can interrupt the body's ability to produce oils, making the skin less supple and more susceptible to extreme dryness. Disease and disorders such as athlete's foot, psoriasis, eczema, and thyroid disease may cause cracked heels. Excess weight can create extra pressure on the feet. Prolonged standing in ill-fitting shoes can become a problem due to added pressure. Poorly structured feet can sometimes lead to abnormal gait that produces calluses to the heel. Water, especially running water, can rob the skin of its natural oils and this can leave the skin dry and rough. Deficiency of vitamins, minerals and zinc can lead to skin breakdown as well. The cracks are socially unattractive and reduce the efficiency in the man. The healing, protection and prevention of cracks in heels and hands is generally done by emollient creams/lotions. There are several products available in market but a few but frequently reported effects include irritation, redness, itching and sensitivity to the sun. Many products need multiple applications every day, for weeks to sooth severe dryness and deep cracks. US publication number 2010/0303742 relates to skin compositions comprising hydrocortisone; allantoin; and a water-based vehicle that is essentially free of petroleum jelly, mineral oil and wax; and related method for protecting, healing and/or soothing the skin. US publication number 2007/0014749 relates to a novel base material for manufacturing cream, comprising of cooling and soothing agent on the skin. The invention relates to herbal compositions suspended in a cream based on novel vehicle "Ghee" (clarified butter). In the present invention, provides a combination of extracts of natural botanicals/herbs formulated in a base. When applied, it reduces the rate of water loss from the surface of the cracked heels and hands to the extent that water is conserved and the horny layer hydrates. The cream is rapidly absorbed through the skin and at the same time natural herbal extracts heal the wound and prevent it from infections making the skin soft and supple. The composition helps reduce severe dryness and pain in a short period of time. Summary of the invention In one general aspect, the present invention relates to a topical composition comprising about 10% to about 30% oil extract wherein the oil extract comprises extracts of at least five different plants wherein at least one plant extract is selected from the group comprising buchanania lanzan extract, cassia tora extract, pongamia glabra extract, shorea robusta extract. In another general aspect, there is provided a topical composition, wherein at least five different plants are selected from the group comprising buchanania lanzan, cassia tora, pongamia glabra, shorea robusta. papavar somniferam, curcuma longa and helianthus annus. In another general aspect, there is provided a topical composition, wherein the oil extract comprises not more than 1% by weight of preservatives. In yet another general aspect, there is provided a topical composition, wherein the composition is in the form of creams, emulsions, dispersions, oils, ointments, balsams, lotions, gels, cream gels or liniments. In another general aspect, there is provided a topical composition, wherein the composition is in the form of cream. Embodiments of the invention may include one or more of the following features. For example the composition may further comprise one or more cosmetically or pharmaceutically acceptable ingredients comprising preservatives/antioxidants/chelating agents, vitamins, dyes/coloring agents, proteins/amino acids, plant extracts, humectants/conditioners/moisturizers, fragrances/perfumes, oils/emollients/lubricants, penetrants, thickeners/viscosity modifiers, surfactants/ detergents/ emulsifiers/opacifying agents, liquid vehicles/solvents and pH adjusting agents/buffers/neutralizing agents. In another general aspect, there is provided a topical composition, wherein the composition further comprises one or more cosmetically or pharmaceutically active ingredients comprising antiseptic agents, antiperspirant agents, anti-inflammatory agents and/or analgesics, anti-itching agents, calming agents, anesthetic agents, skin relaxant agents, free radical scavengers and/or agents against atmospheric pollution, reactive carbonyl species scavengers, antimicrobial agents, antifungal agents, fungistatic agents, bactericidal agents, bacteriostatic agents, agents stimulating the synthesis of dermal or epidermal macromolecules and/or capable of inhibiting or preventing their degradation, collagen synthesis-stimulating agents, elastin synthesis-stimulation agents, agents stimulating the synthesis of lipids and components of the stratum corneum, ceramides, fatty acids, agents that inhibit collagen degradation, matrix metalloproteinase inhibitory agents, agents that inhibit elastin degradation, comedolytic agents, , stabilizers, agents for the treatment and/or care of sensitive skin, binding agents, agents regulating sebum production, agents stimulating healing, coadjuvant healing agents, agents stimulating reepithelialization and coadjuvant reepithelialization agents.
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