31st European Congress of Pathology Pathology is Nice 7 – 11 September 2019 Nice Acropolis Convention Centre, France Final www.esp-congress.org Programme ECP 2019 · Nice Table of Contents page page Welcome Address 4 Two-Day Molecular Pathology Diagnostics Symposium 69 Committees and Organisers 5 Monday, 9 September 2019 70 Tuesday, 10 September 2019 71 Keynote Speakers 7 One-Day Computational Bursaries 11 Pathology Symposium 75 Sunday, 8 September 2019 76 CME Accreditation 13 Poster Sessions 79 Venue Overview 15 Sunday, 8 September 2019 80 Monday, 9 September 2019 91 Programme Overview 16 Tuesday, 10 September 2019 102 Colour Legend 16 Wednesday, 11 September 2019 113 Saturday, 7 September 2019 17 Sunday, 8 September 2019 18 E-Posters 125 Monday, 9 September 2019 20 Tuesday, 10 September 2019 22 Congress Information 173 Wednesday, 11 September 2019 24 Industry Symposia 179 Scientific Programme 27 Saturday, 7 September 2019 28 Acknowledgements 185 Sunday, 8 September 2019 28 Monday, 9 September 2019 38 Exhibition Floor Plan 187 Tuesday, 10 September 2019 49 Wednesday, 11 September 2019 62 List of Exhibitors 190 Social Events 195 Index of Authors 198 e Host Organisation e Congress and Exhibition Office European Society of Pathology Rue Bara 6 1070 Brussels, Belgium CPO HANSER SERVICE GmbH www.esp-pathology.org Paulsborner Str. 44 14193 Berlin, Germany e Scientific Contact Phone: +49 – 30 – 300 669-0 Raed Al Dieri Fax: +49 – 30 – 305 73 91 ESP Director General Email: [email protected] Rue Bara 6 1070 Brussels, Belgium e Congress Venue Email: [email protected] Nice Acropolis Convention Centre 1 Esplanade Kennedy 06364 Nice cedex 4 France 3 Welcome Address ECP 2019 · Nice Dear Colleague, On behalf of the European Society of Pathology (ESP) and the French Society of Pathology we would like to welcome you to Nice, for the 31st European Congress of Pathology (ECP 2019). The theme for the ECP 2019 is direct and easy to memorise: “Pathology is Nice”. This week Nice is the capital of Europe- an and International Pathology, where pathologists and their collaborators, molecular biologists, geneticists, bioinformati- cians, and information technologists meet to share advances in our discipline that offers diagnostic, prognostic and predic- Dina Tiniakos tive information essential for best patient care. For ECP 2019, the ESP working groups have prepared state- of-the-art organ-based sessions while collaborating patholo- gy and clinical scientifi c societies interact in joint scientifi c events. The energetic ESP Trainee Subcommittee has planned sessions attractive for junior pathologists, while special sessions focusing on advances in molecular pathology, in- formation technology, quality assessment, education, histo- technology and public awareness complete the diverse pro- gramme. Every day, a keynote lecture by distinguished inter- national experts highlights burning issues in pathology and beyond. We envisage exciting oral free paper and best poster Paul Hofman sessions where novel translational research will be presented, while diffi culties in the diagnosis of rare disease entities are discussed in poster sessions. Attending the 31st ECP will also give you the opportunity to learn more about the Capital of the French Riviera, ideally lo- cated between the Mediterranean Sea and the Alps in a land- scape of incomparable natural beauty. Nice is a city of history, culture, art, nature, and gastronomy whose maritime scents and earthy fl avours will accompany you in every step. We are delighted to welcome you and share with you a memorable time in charming Nice! Dina Tiniakos, Greece / UK President of the European Society of Pathology Paul Hofman, France Chair of the Local Organising Committee of ECP 2019 4 ECP 2019 · Nice Committees and Organisers e Brief Description of the ESP e Scientific / Organising Committee The European Society of Pathology (ESP) Dina Tiniakos, Greece / UK was founded by a small group of eminent Fátima Carneiro, Portugal pathologists in 1963. The Society was of- Pierre Bedossa, France ficially registered in Brussels, Belgium as Raed Al Dieri, Belgium an international non-profit organisation on Jean-François Fléjou, France 7th November 1964. The ESP is a leading Paul Hofman, France force in European pathology and, as such, Jean-Christophe Sabourin, France is pivotal to the future of the specialty in Eu- rope and beyond. As a scientific society, the ESP has, as its primary aim, the promotion e ESP Executive Comittee and of high quality diagnostic practice, applied Council and translational research and under- and President: postgraduate education in the field of hu- Dina Tiniakos, Greece / UK man pathology. This is achieved through its President-elect: congresses, its journal Virchows Archiv and Holger Moch, Switzerland various other activities. The ESP interacts Secretary: with national pathology societies in Europe Aurelio Ariza, Spain and has developed links with other EU bod- Treasurer: ies in close collaboration with UEMS (Union Marco Santucci, Italy Européenne des Médecins Spécialistes) and Past President: EAPCP (European Association of Pathology Pierre Bedossa, France Chairs and Programme Directors). Members: The European School of Pathology un- Peter Schirmacher, Germany der the auspices of the ESP and with Metka Volavšek, Slovenia the support of 20 Working Groups and Tibor Tot, Sweden 5 Affiliated Societies representing differ- Cord Langner, Austria ent fields of pathology is involved in the Xavier Matias-Guiu, Spain organisation of courses to meet the needs Glenn McCluggage, UK of young pathologists. The ESP Foundation Maria Rosaria Raspollini, Italy provides external quality assessment (QA) Anastasia Konstantinidou, Greece programmes for several biomarkers. Diag- Chair of the Advisory Board: nostic laboratories worldwide participate in Fátima Carneiro, Portugal the ESP Foundation QA schemes, such as ESP Director General: Lung and Colon. Raed Al Dieri, Belgium Office of the ESP Rue Bara 6, 1070 Brussels, Belgium Phone: +32 – 25208036 Email: [email protected] www.esp-pathology.org 5 Committees and Organisers ECP 2019 · Nice e Working Groups of the ESP Chair of the ESP Working Groups: Pierre Bedossa, France 1. Autopsy Pathology 12. IT (Computational) Chair: C. Alfsen, Norway Chair: G. Kayser, Germany Co-Chair: M. Haab, Germany 13. Molecular Pathology 2. Breast Pathology Chair: G. Höfler, Austria Chair: T. Tot, Sweden Co-Chair: G. Stanta, Italy Co-Chair: G. Cserni, Hungary 14. Nephropathology 3. Cytopathology Chair: K. Amann, Germany Chair: P. Vielh, France Co-Chair: H. Hopfer, Switzerland Co-Chair: G. Troncone, Italy 15. Paediatric and Perinatal Pathology 4. Dermatopathology Chair: I. Colmenero, Spain Chair: E. Calonje, UK Co-Chair: A. Coulomb, France Co-Chair: B. Luzar, Slovenia 16. Pathology in Favour of Developing 5. Digestive Diseases Pathology Countries Chair: J.-F. Fléjou, France Chair: S. Guzzetti, Italy Co-Chair: C. Sempoux, Switzerland Co-Chair: G. de Falco, Italy 6. Electron Microscopy 17. Pulmonary Pathology Chair: G. Cennachi, Italy Chair: F. Calabrese, Italy Co-Chair: D. Naranjo-Hans, Spain Co-Chair: I. Kern, Slovenia 7. Endocrine Pathology 18. Soft Tissue and Bone Pathology Chair: J.-Y. Scoazec; France Chair: F. Le Loarer, France Co-Chair: C. Eloy, Portugal Co-Chair: D. Baumhoer, Switzerland 8. Gynaecological Pathology 19. Thymic and Mediastinal Pathology Chair: S. Stolnicu, Romania Chair: P. Ströbel, Germany Co-Chair: A. Vidal Bel, Spain Co-Chair: M. Szolkowska, Poland 9. Head and Neck Pathology 20. Uropathology Chair: T. R. Helliwell, UK Chair: A. Lopez-Beltran, Spain Co-Chair: N. Zidar, Slovenia Co-Chair: M. Colecchia, Italy 10. History of Pathology Chair: G. Nesi, Italy 11. Infectious Diseases Pathology Chair: G. Gorkiewicz, Austria Co-Chair: N. Rakislova, Spain e Affiliated Societies e Cardiovascular Pathology e Ophthalmic Pathology President: J. Lucena, Spain President: R. M. Verdijk, Secretary: G. D'Amati, Italy The Netherlands e Haematopathology e Paediatric Pathology President: D. de Jong, The Netherlands President: G. Vujanic, Qatar Secretary: B. Sander, Sweden Secretary: S. Holden, UK e Neuropathology (Euro – CNS) President: P. Ince, UK 6 ECP 2019 · Nice Keynote Speakers e Michael Middleton (USA) Dr Middleton is a Radiologist, and Director of Clinical Trials for the Liver Imaging Group at the University of California, San Diego. He is on the NASH CRN (Nonalcoholic Steatohepatitis Clinical Research Network) Steering Committee and the PDFF (proton density fat fraction) and MRE (magnetic resonance elastography) quantitative imaging biomarker committees as part of QIBA (Quantative Imaging Biomarkers Alliance), part of the NIMBLE (Non-Invasive BioMarkers of MetaBolic Liver DiseasE) Imaging Workstream Group, and has been author or co-author of numerous publications in the field. For the last 12 years he has been involved extensively in the implementation, analysis, and quality control of quantitative magnitude MRI-PDFF (magnetic resonance imaging-proton density fat fraction) and MRE liver stiffness imaging exams in 28 drug development clinical trials involving several thousand pharmaceutical industry MR scans obtained at over 300 sites worldwide. This work has enabled a working, practical understanding of how to implement MRI PDFF and MRE liver stiffness estimation sequences on a wide variety of different styles and models of scanners from most of the major MRI scanner manufacturers, and to identify and correct scanner- and sequence-specific problems. It has also