Download Leaflet View the Patient Leaflet in PDF Format

Total Page:16

File Type:pdf, Size:1020Kb

Download Leaflet View the Patient Leaflet in PDF Format PACKAGE LEAFLET: Take special care with Cefalexin: INFORMATION FOR Acute generalised exanthematous (AGEP) THE USER has been reported with the use of cefalexin. AGEP appears at the initiation of treatment Cefalexin as a red, scaly widespread rash with bumps Capsules 250mg under the skin and blisters accompanied by Cefalexin fever. The most common location: mainly Capsules 500mg localised on the skin folds, trunk, and upper cefalexin extremities. The highest risk of occurence of this serious skin reaction is within the first week of treatment. If you develop a Read all of this leaflet carefully before serious skin rash or another of these skin you start taking this medicine because it symptoms, stop taking cefalexin and contact contains important information for you. your doctor or seek medical attention - Keep this leaflet. You may need to read immediately. it again. Other medicines and Cefalexin Capsules - If you have any further questions, ask Tell your doctor or pharmacist if you are your doctor or pharmacist. taking, have recently taken or might take - This medicine has been prescribed for any other medicines, including medicines you only. Do not pass it on to others. It obtained without a prescription. may harm them, even if their signs of This is especially important of the following, illness are the same as yours as they may interact with your Cefalexin: - If you get any side effects, talk to your • Any other antibiotics (e.g. gentamicin, doctor or pharmacist. This includes any tobramycin, cefuroxime) possible side effects not listed in this • Potent diuretics e.g. furosemide (water leaflet. See section 4. tablets used to treat high blood pressure What is in this leaflet: or water retention) 1. What Cefalexin Capsules are and what • Probenecid (a treatment for gout) they are used for • Metformin (a treatment for diabetes) 2. What you need to know before you take • Drugs used to treat leukaemia. Cefalexin Capsules It may be still be all right for you to be given 3. How to take Cefalexin Capsules Cefalexin Capsules and your doctor will be 4. Possible side effects able to decide what is suitable for you. 5. How to store Cefalexin Capsules 6. Contents of the pack and other Pregnancy and breast-feeding If you are pregnant or breast-feeding, think information you may be pregnant or are planning to 1. WHAT CEFALEXIN CAPSULES ARE have a baby, ask your doctor or pharmacist AND WHAT THEY ARE USED FOR for advice before taking this medicine. Driving and using machines Cefalexin Capsules contain cefalexin as Cefalexin Capsules should not affect your the active ingredient, which belongs to a ability to drive or use machines. class of antibiotics called ‘cephalosporins’. Cefalexin Capsules are used to treat Cefalexin Capsule contains Lactose following infections caused by bacteria that If you have been told by your doctor that can be killed by cefalexin: you have an intolerance to some sugars, • Respiratory tract (lung and airways) e.g. contact your doctor before taking this tonsillitis, pharyngitis and bronchitis medicinal product • Middle ear infections (otitis media) • Skin and soft tissue (e.g. muscle) 3. HOW TO TAKE CEFALEXIN infections CAPSULES • Bone and joint infections Always take this medicine exactly as your • Infections of the reproductive organs doctor or pharmacist has told you. Check and urinary tract (e.g. cystitis), including with your doctor or pharmacist if you are not acute inflammation of the prostate gland sure. (prostatitis) These capsules may be taken before, • Dental infections. during or after your meals. 2. WHAT YOU NEED TO KNOW Dosage BEFORE YOU TAKE CEFALEXIN Adults and the elderly CAPSULES The recommended total daily dose is 1-4 g orally, in divided doses. Do not take Cefalexin Capsules: • Most infections can be treated by • If you are allergic to cefalexin, other 500 mg every 8 hours. For skin and cephalosporins (similar antibiotics) soft tissue infections, sore throat or any of the other ingredients of this (streptococcal pharyngitis), and mild, medicine (listed in Section 6). An allergic uncomplicated urinary tract infections, reaction may include rash, itching, the usual dose is 250 mg every 6 hours, difficulty breathing or swelling of the or 500 mg every 12 hours. face, lips, throat or tongue. • For more severe infections, larger doses Tell your doctor before taking Cefalexin: may be needed. A reduced dose is • If you have ever developed a severe needed for patients with severe kidney skin rash or skin peeling, blistering and/ disorders. or mouth sores after taking cefalexin or Use in children other antibacterials. The usual total daily dose for children is Warnings and precautions 25-50 mg/kg (body weight) in divided doses. Talk to your doctor or pharmacist before • For skin and soft tissue infections, taking Cefalexin Capsules if you: streptococcal pharyngitis, and mild, • Have had allergic reaction to cefalexin, uncomplicated urinary tract infections, cephalosporins, penicillins or other drugs the total daily dose may be divided and in the past administered every 12 hours. • Develop severe or prolonged diarrhoea For most infections the following schedule is during or after taking cefalexin suggested: • Have a severe kidney disorder (you may Children under 5 years: 125 mg every 8 need reduced dose) hours. • have ever developed a severe skin rash Children 5 years and over: 250 mg every or skin peeling, blistering and/or mouth 8 hours. sores after taking cefalexin or other In severe infections, the dose may be antibacterials doubled. In the treatment of middle ear Tell your doctor if you are having blood and infections, a total daily dose of 75 to urine Cefalexin may interfere with these 100 mg/kg in 4 doses is required. tests. P15XXXXX Black Version: 04 Date & Time: 13.09.2021 & 11.40 AM Supersede Item Code: N08418 If you have any further • Discharge from the vagina caused by questions on the use of thrush this product, ask your • Nervousness doctor or pharmacist. • Sleep disturbances • Arthritis and joint disorder If you take more • Hypertonia (increased tightness of Cefalexin Capsules than muscle tone) you should Contact your doctor or Frequency not known: nearest hospital casualty A red, scaly widespread rash with bumps department immediately under the skin and blisters accompanied for advice if you or a by fever at the initiation of treatment (acute child have swallowed generalised exanthematous pustulosis). too many capsules. Take Stop using cefalexin if you develop these this leaflet, the pack or symptoms and contact your doctor or seek any capsules with you, medical attention immediately. See also if you can. Symptoms of section 2. overdose include nausea, vomiting, stomach upset, Reporting of side effects If you get any side effects, talk to your appearance of blood in doctor, pharmacist or nurse. This includes the urine. any possible side effects not listed in this If you forget to take Cefalexin Capsules leaflet. You can also report side effects If you miss a dose, take it as soon as you directly via the Yellow Card Scheme at: remember. If it is almost time to take the www.mhra.gov.uk/yellowcard or search for next dose, skip the missed dose and carry MHRA Yellow Card in the Google Play or on as before. Do not take a double dose to Apple App Store. make up for a forgotten dose. By reporting side effects you can help If you have any further questions on the provide more information on the safety of use of this medicine, ask your doctor or this medicine. pharmacist. 5. HOW TO STORE CEFALEXIN 4. POSSIBLE SIDE EFFECTS CAPSULES Like all medicines, Cefalexin Capsules can Keep this medicine out of the sight and cause side effects, although not everyone reach of children. gets them. Do not store above 25°C. Tell your doctor immediately if you get any sudden wheeziness, difficulty in Store Cefalexin Capsules in their original breathing, swelling of the eyelids, face or package and keep containers tightly closed. lips, rash or itching (especially affecting your Do not use the capsules after the expiry whole body). ‘EXP’ date which is printed on the carton Serious side effects (the expiry date refers to the last day of the The following side effects are serious. You month stated). should stop taking this medicine and contact Medicines should not be disposed of via your doctor immediately if you experience wastewater or household waste. Ask your them: pharmacist how to dispose of medicines no • Serious peeling or blistering of the longer required. These measures will help to skin protect the environment. • Severe diarrhoea • A red, scaly widespread rash with 6. CONTENTS OF THE PACK AND bumps under the skin and blisters OTHER INFORMATION accompanied by fever at the initiation of treatment (acute generalised What Cefalexin Capsules contain exanthematous pustulosis). Stop The active ingredient is cefalexin, 250mg or using cefalexin if you develop these 500mg. symptoms and contact your doctor or The other ingredients are lactose, seek medical attention immediately. magnesium stearate. The capsule shell See also section 2. contains black iron oxide (E172), titanium The following side effects have been dioxide (E171), erythrosin (E127), quinoline reported yellow (E104) and gelatin. • Diarrhoea What Cefalexin Capsules look like and • Feeling sick (nausea) contents of the pack • Vomiting Cefalexin Capsules are grey/orange capsule • Indigestion containing white powder and printed with • Stomach pains ‘CHX 250’ (250mg) or ‘CHX 500’ (500mg). • Measles-like rash, (alone) They are available in blisters pack of 7, • Itching 14, 20, 21, 28, 30, 50, 56, 60, 100, or 500 • Red wheals on the skin (urticaria) capsules (alone) (not all pack sizes may be marketed). • Rash with wide spread joint pain and/ Marketing Authorisation Holder or stiffness, swollen lymph glands, fever Marketing Authorisation Holder: and, possibly, cloudy urine Milpharm Limited • Changes in blood counts, which may Ares, Odyssey Business Park, show up as bruising or a very tired West End Road, feeling.
Recommended publications
  • Ceftazidime for Injection) PHARMACY BULK PACKAGE – NOT for DIRECT INFUSION
    PRESCRIBING INFORMATION FORTAZ® (ceftazidime for injection) PHARMACY BULK PACKAGE – NOT FOR DIRECT INFUSION To reduce the development of drug-resistant bacteria and maintain the effectiveness of FORTAZ and other antibacterial drugs, FORTAZ should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. DESCRIPTION Ceftazidime is a semisynthetic, broad-spectrum, beta-lactam antibacterial drug for parenteral administration. It is the pentahydrate of pyridinium, 1-[[7-[[(2-amino-4­ thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1­ azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, hydroxide, inner salt, [6R-[6α,7β(Z)]]. It has the following structure: The molecular formula is C22H32N6O12S2, representing a molecular weight of 636.6. FORTAZ is a sterile, dry-powdered mixture of ceftazidime pentahydrate and sodium carbonate. The sodium carbonate at a concentration of 118 mg/g of ceftazidime activity has been admixed to facilitate dissolution. The total sodium content of the mixture is approximately 54 mg (2.3 mEq)/g of ceftazidime activity. The Pharmacy Bulk Package vial contains 709 mg of sodium carbonate. The sodium content is approximately 54 mg (2.3mEq) per gram of ceftazidime. FORTAZ in sterile crystalline form is supplied in Pharmacy Bulk Packages equivalent to 6g of anhydrous ceftazidime. The Pharmacy Bulk Package bottle is a container of sterile preparation for parenteral use that contains many single doses. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous use. THE PHARMACY BULK PACKAGE IS NOT FOR DIRECT INFUSION, FURTHER DILUTION IS REQUIRED BEFORE USE.
    [Show full text]
  • Cefalexin in the WHO Essential Medicines List for Children Reject
    Reviewer No. 1: checklist for application of: Cefalexin In the WHO Essential Medicines List for Children (1) Have all important studies that you are aware of been included? Yes No 9 (2) Is there adequate evidence of efficacy for the proposed use? Yes 9 No (3) Is there evidence of efficacy in diverse settings and/or populations? Yes 9 No (4) Are there adverse effects of concern? Yes 9 No (5) Are there special requirements or training needed for safe/effective use? Yes No 9 (6) Is this product needed to meet the majority health needs of the population? Yes No 9 (7) Is the proposed dosage form registered by a stringent regulatory authority? Yes 9 No (8) What action do you propose for the Committee to take? Reject the application for inclusion of the following presentations of cefalexin: • Tablets/ capsules 250mg • Oral suspensions 125mg/5ml and 125mg/ml (9) Additional comment, if any. In order to identify any additional literature, the following broad and sensitive search was conducted using the PubMed Clinical Query application: (cephalexin OR cefalexin AND - 1 - pediatr*) AND ((clinical[Title/Abstract] AND trial[Title/Abstract]) OR clinical trials[MeSH Terms] OR clinical trial[Publication Type] OR random*[Title/Abstract] OR random allocation[MeSH Terms] OR therapeutic use[MeSH Subheading]) Only one small additional study was identified, which looked at the provision of prophylactic antibiotics in patients presenting to an urban children's hospital with trauma to the distal fingertip, requiring repair.1 In a prospective randomised control trial, 146 patients were enrolled, of which 69 were randomised to the no-antibiotic group, and 66 were randomised to the antibiotic (cefalexin) group.
    [Show full text]
  • Severe Sepsis and Septic Shock Antibiotic Guide
    Stanford Health Issue Date: 05/2017 Stanford Antimicrobial Safety and Sustainability Program Severe Sepsis and Septic Shock Antibiotic Guide Table 1: Antibiotic selection options for healthcare associated and/or immunocompromised patients • Healthcare associated: intravenous therapy, wound care, or intravenous chemotherapy within the prior 30 days, residence in a nursing home or other long-term care facility, hospitalization in an acute care hospital for two or more days within the prior 90 days, attendance at a hospital or hemodialysis clinic within the prior 30 days • Immunocompromised: Receiving chemotherapy, known systemic cancer not in remission, ANC <500, severe cell-mediated immune deficiency Table 2: Antibiotic selection options for community acquired, immunocompetent patients Table 3: Antibiotic selection options for patients with simple sepsis, community acquired, immunocompetent patients requiring hospitalization. Risk Factors for Select Organisms P. aeruginosa MRSA Invasive Candidiasis VRE (and other resistant GNR) Community acquired: • Known colonization with MDROs • Central venous catheter • Liver transplant • Prior IV antibiotics within 90 day • Recent MRSA infection • Broad-spectrum antibiotics • Known colonization • Known colonization with MDROs • Known MRSA colonization • + 1 of the following risk factors: • Prolonged broad antibacterial • Skin & Skin Structure and/or IV access site: ♦ Parenteral nutrition therapy Hospital acquired: ♦ Purulence ♦ Dialysis • Prolonged profound • Prior IV antibiotics within 90 days ♦ Abscess
    [Show full text]
  • Medicines to Treat Bacterial Infections
    Government of Western Australia North Metropolitan Health Service Women and Newborn Health Service Medicines to treat bacterial infections This brochure contains some information on Important: Antibiotic resistance can the medicines you may have been prescribed affect us all. to treat a bacterial infection either in hospital or on discharge. Please talk to your doctor or Help limit the development of antibiotic pharmacist if you would like more information resistance by using antibiotics correctly. on a specific antibiotic. Make sure you: Take antibiotics exactly as prescribed. What is an antibiotic? • Antibiotics are medicines used to treat • Follow instructions on how many times a infections caused by bacteria. They are not day and for how long to take them. effective against viral infections such as the • Do not stop treatment early, even if you common cold and the ‘flu’. feel better. Medicine Other information Amoxicillin May be taken with or without food. Amoxicillin/ Take with the first bite of a meal. clavulanic acid Cefalexin May be taken with or without food. Take on an empty stomach with a glass of water, 1 hour before or 2 hours after food. Ciprofloxacin Do not take dairy products, antacids, iron, zinc or calcium within 2 hours of the dose. Clindamycin Take with a full glass of water. May be taken with or without food. Take with food or milk. Remain upright for an hour after dose to prevent damage to the Doxycycline lining of your throat. Do not take dairy products, antacids, iron, zinc or calcium within 2 hours of the dose. Take on an empty stomach, 1 hour before or 2 hours after food.
    [Show full text]
  • Antimicrobial Stewardship Guidance
    Antimicrobial Stewardship Guidance Federal Bureau of Prisons Clinical Practice Guidelines March 2013 Clinical guidelines are made available to the public for informational purposes only. The Federal Bureau of Prisons (BOP) does not warrant these guidelines for any other purpose, and assumes no responsibility for any injury or damage resulting from the reliance thereof. Proper medical practice necessitates that all cases are evaluated on an individual basis and that treatment decisions are patient-specific. Consult the BOP Clinical Practice Guidelines Web page to determine the date of the most recent update to this document: http://www.bop.gov/news/medresources.jsp Federal Bureau of Prisons Antimicrobial Stewardship Guidance Clinical Practice Guidelines March 2013 Table of Contents 1. Purpose ............................................................................................................................................. 3 2. Introduction ...................................................................................................................................... 3 3. Antimicrobial Stewardship in the BOP............................................................................................ 4 4. General Guidance for Diagnosis and Identifying Infection ............................................................. 5 Diagnosis of Specific Infections ........................................................................................................ 6 Upper Respiratory Infections (not otherwise specified) ..............................................................................
    [Show full text]
  • Antibiotic Use Guidelines for Companion Animal Practice (2Nd Edition) Iii
    ii Antibiotic Use Guidelines for Companion Animal Practice (2nd edition) iii Antibiotic Use Guidelines for Companion Animal Practice, 2nd edition Publisher: Companion Animal Group, Danish Veterinary Association, Peter Bangs Vej 30, 2000 Frederiksberg Authors of the guidelines: Lisbeth Rem Jessen (University of Copenhagen) Peter Damborg (University of Copenhagen) Anette Spohr (Evidensia Faxe Animal Hospital) Sandra Goericke-Pesch (University of Veterinary Medicine, Hannover) Rebecca Langhorn (University of Copenhagen) Geoffrey Houser (University of Copenhagen) Jakob Willesen (University of Copenhagen) Mette Schjærff (University of Copenhagen) Thomas Eriksen (University of Copenhagen) Tina Møller Sørensen (University of Copenhagen) Vibeke Frøkjær Jensen (DTU-VET) Flemming Obling (Greve) Luca Guardabassi (University of Copenhagen) Reproduction of extracts from these guidelines is only permitted in accordance with the agreement between the Ministry of Education and Copy-Dan. Danish copyright law restricts all other use without written permission of the publisher. Exception is granted for short excerpts for review purposes. iv Foreword The first edition of the Antibiotic Use Guidelines for Companion Animal Practice was published in autumn of 2012. The aim of the guidelines was to prevent increased antibiotic resistance. A questionnaire circulated to Danish veterinarians in 2015 (Jessen et al., DVT 10, 2016) indicated that the guidelines were well received, and particularly that active users had followed the recommendations. Despite a positive reception and the results of this survey, the actual quantity of antibiotics used is probably a better indicator of the effect of the first guidelines. Chapter two of these updated guidelines therefore details the pattern of developments in antibiotic use, as reported in DANMAP 2016 (www.danmap.org).
    [Show full text]
  • Synermox 500 Mg/125 Mg Tablets
    New Zealand Data Sheet 1. PRODUCT NAME Synermox 500 mg/125 mg Tablets 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Synermox 500 mg/125 mg Tablets: Each film‐coated tablet contains amoxicillin trihydrate equivalent to 500 mg amoxicillin, with potassium clavulanate equivalent to 125 mg clavulanic acid. Excipient(s) with known effect For the full list of excipients, see section 6.1. 3. PHARMACEUTICAL FORM Synermox 500 mg/125 mg Tablets: White to off‐white, oval shaped film‐coated tablets, debossed with “RX713” on one side and plain on the other. 4. CLINICAL PARTICULARS 4.1. Therapeutic indications Synermox is indicated in adults and children (see sections 4.2, 4.4 and 5.1) for short term treatment of common bacterial infections such as: Upper Respiratory Tract Infections (including ENT) e.g. Tonsillitis, sinusitis, otitis media. Lower Respiratory Tract Infection e.g. acute exacerbations of chronic bronchitis, lobar and broncho‐pneumonia. Genito‐urinary Tract Infections e.g. Cystitis, urethritis, pyelonephritis, female genital infections. Skin and Soft Tissue Infections. Bone and Joint Infections e.g. Osteomyelitis. Other Infections e.g. septic abortion, puerperal sepsis, intra‐abdominal sepsis, septicaemia, peritonitis, post‐surgical infections. Synermox is indicated for prophylaxis against infection which may be associated with major surgical procedures such as those involving: Gastro‐intestinal tract Pelvic cavity 1 | Page Head and neck Cardiac Renal Joint replacement Biliary tract surgery Infections caused by amoxicillin susceptible organisms are amenable to Synermox treatment due to its amoxicillin content. Mixed infections caused by amoxicillin susceptible organisms in conjunction with Synermox‐susceptible beta‐lactamase‐producing organisms may therefore be treated by Synermox.
    [Show full text]
  • IV Vancomycin Dosing and Monitoring Antibiotic Guidelines Reference Number: 144TD(C)25(H3) Version Number: 6.1 Issue Date: 21/07/2020 Page 1 of 12
    Group arrangements: Salford Royal NHS Foundation Trust (SRFT) Pennine Acute Hospitals NHS Trust (PAT) IV Vancomycin dosing and monitoring Antibiotic Guidelines Lead Author: Antibiotic Steering Group Additional author(s) Elizabeth Trautt, Consultant Microbiologist; Sue Wei Chong, Antimicrobial Pharmacist Division/ Department:: NCA Diagnostics and Pharmacy Group Applies to: Salford Royal Care Organisation Approving Committee Medicines Management Group Date approved: 02/07/2020 Expiry date: July 2023 Contents Contents 1. Overview (What is this guideline about?) ....................................................................... 2 2. Scope (Where will this document be used?) .................................................................. 2 3. Background (Why is this document important?) ............................................................. 2 4. What is new in this version? ............................................................................................ 3 5. Guideline ......................................................................................................................... 3 5.1 Method of administration ................................................................................................. 3 5.2. Dose calculation .............................................................................................................. 3 5.3. Patients with Renal failure/Kidney disease (CrCl<30ml/min or dialysis) .......................... 4 5.4 Therapeutic drug level monitoring ..................................................................................
    [Show full text]
  • Eml-2017-Antibacterials-Eng.Pdf
    Consideration of antibacterial medicines as part of the revisions to 2017 WHO Model List of Essential Medicines for adults (EML) and Model List of Essential Medicines for children (EMLc) Section 6.2 Antibacterials including Access, Watch and Reserve Lists of antibiotics This summary has been prepared by the Health Technologies and Pharmaceuticals (HTP) programme at the WHO Regional Office for Europe. It is intended to communicate changes to the 2017 WHO Model List of Essential Medicines for adults (EML) and Model List of Essential Medicines for children (EMLc) to national counterparts involved in the evidence-based selection of medicines for inclusion in national essential medicines lists (NEMLs), lists of medicines for inclusion in reimbursement programs, and medicine formularies for use in primary, secondary and tertiary care. This document does not replace the full report of the WHO Expert Committee, 2017 and this summary should be read in conjunction with the full report (WHO Technical Report Series, No. 1006; http://apps.who.int/iris/bitstream/10665/259481/1/9789241210157-eng.pdf?ua=1). The revised lists of essential medicines (in English) are available as follows: 2017 WHO Model List of Essential Medicines for adults (EML) http://www.who.int/medicines/publications/essentialmedicines/20th_EML2017_FINAL_amend edAug2017.pdf?ua=1 2017 Model List of Essential Medicines for children (EMLc) http://www.who.int/medicines/publications/essentialmedicines/6th_EMLc2017_FINAL_amend edAug2017.pdf?ua=1 Summary of changes to Section 6.2 Antibacterials: Section 6 of the EML covers anti-infective medicines. Disease-specific subsections within Section 6, such as those covering medicines for tuberculosis, HIV, hepatitis and malaria, have been regularly reviewed and updated, taking into consideration relevant WHO treatment guidelines.
    [Show full text]
  • Computational Antibiotics Book
    Andrew V DeLong, Jared C Harris, Brittany S Larcart, Chandler B Massey, Chelsie D Northcutt, Somuayiro N Nwokike, Oscar A Otieno, Harsh M Patel, Mehulkumar P Patel, Pratik Pravin Patel, Eugene I Rowell, Brandon M Rush, Marc-Edwin G Saint-Louis, Amy M Vardeman, Felicia N Woods, Giso Abadi, Thomas J. Manning Computational Antibiotics Valdosta State University is located in South Georgia. Computational Antibiotics Index • Computational Details and Website Access (p. 8) • Acknowledgements (p. 9) • Dedications (p. 11) • Antibiotic Historical Introduction (p. 13) Introduction to Antibiotic groups • Penicillin’s (p. 21) • Carbapenems (p. 22) • Oxazolidines (p. 23) • Rifamycin (p. 24) • Lincosamides (p. 25) • Quinolones (p. 26) • Polypeptides antibiotics (p. 27) • Glycopeptide Antibiotics (p. 28) • Sulfonamides (p. 29) • Lipoglycopeptides (p. 30) • First Generation Cephalosporins (p. 31) • Cephalosporin Third Generation (p. 32) • Fourth-Generation Cephalosporins (p. 33) • Fifth Generation Cephalosporin’s (p. 34) • Tetracycline antibiotics (p. 35) Computational Antibiotics Antibiotics Covered (in alphabetical order) Amikacin (p. 36) Cefempidone (p. 98) Ceftizoxime (p. 159) Amoxicillin (p. 38) Cefepime (p. 100) Ceftobiprole (p. 161) Ampicillin (p. 40) Cefetamet (p. 102) Ceftoxide (p. 163) Arsphenamine (p. 42) Cefetrizole (p. 104) Ceftriaxone (p. 165) Azithromycin (p.44) Cefivitril (p. 106) Cefuracetime (p. 167) Aziocillin (p. 46) Cefixime (p. 108) Cefuroxime (p. 169) Aztreonam (p.48) Cefmatilen ( p. 110) Cefuzonam (p. 171) Bacampicillin (p. 50) Cefmetazole (p. 112) Cefalexin (p. 173) Bacitracin (p. 52) Cefodizime (p. 114) Chloramphenicol (p.175) Balofloxacin (p. 54) Cefonicid (p. 116) Cilastatin (p. 177) Carbenicillin (p. 56) Cefoperazone (p. 118) Ciprofloxacin (p. 179) Cefacetrile (p. 58) Cefoselis (p. 120) Clarithromycin (p. 181) Cefaclor (p.
    [Show full text]
  • Can Amoxicillin Clavulanate Be Used for Treating MRSA?
    ORIGINAL ARTICLE Can amoxicillin clavulanate be used for treating MRSA? Sana Jamil1, Uzma Saad2, Saleem Hafiz1 Jamil S, Saad U, Hafiz S. Can amoxicillin clavulanate be used for treating positive for Beta lactamase production 52.1% of these Beta lactamase MRSA? J Pharmacol Res December-2017;1(1):21-23. producing MRSA were sensitive to amoxicillin-clavulanate and the remaining (47.9%) were resistant. Objective: To determine the frequency of beta lactamase producing Conclusion: If beta lactamase producing Staphlococcus aureus are tested Staphlococcus aureus and their sensitivity to Amoxicillin clavulanate in against beta-lactam antimicrobial agents in combination with clavulanic major cities of Pakistan. acid or sulbactam (Beta-lactamase inhibitors), they become susceptible to Setting: Various laboratories of the country with one as the central the Beta-lactam antimicrobial agents. This might have therapeutic and Laboratory. epidemiological implications in near future. Materials and Methods: Seven hundred and ninety two consecutive Key Words: Methicillin resistant Staphylococcus aureus; Vancomycin clinical isolates of Staphylococcus aureus were collected from 8 intermediate Staphylococcus aureus; Vancomycin resistant Staphylococcus laboratories all over Pakistan i.e. Karachi, Peshawar, Lahore, Sukkhur, aureus; Clinical laboratory standard institute; Penicillinase resistant Islamabad, Quetta, and Mirpur, Azad Kashmir. Antibiotic sensitivity was penicillins; Minimum inhibitory concentration; Penicillin binding proteins; done by Kirby Bauer disc diffusion method and Beta lactamase production Center of disease control was identified by using Nitrocefin test. Results: Forty two percent of the isolates were found to be Methicillin resistant Staphylococcus aureus (MRSA) out of which 87.9% were INTRODUCTION lactamase producing MRSA in Pakistan and its sensitivity to Amoxicillin clavulanate.
    [Show full text]
  • Antibiotic Use for Sepsis in Neonates and Children: 2016 Evidence Update
    Antibiotic Use for Sepsis in Neonates and Children: 2016 Evidence Update Aline Fuchsa, Julia Bielickia,b, Shrey Mathurb, Mike Sharlandb, Johannes N. Van Den Ankera,c a Paediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel, Basel, Switzerland b Paediatric Infectious Disease Research Group, Institute for Infection and Immunity, St George's University of London, London, United Kingdom c Division of Clinical Pharmacology, Children’s National Health System, Washington, DC, USA WHO-Reviews 1 TABLE OF CONTENTS 1. INTRODUCTION ............................................................................................................................... 3 1.1. Aims ......................................................................................................................................... 3 1.2. Background ............................................................................................................................. 3 1.2.1. Definition and diagnosis ................................................................................................. 3 Neonatal Sepsis ............................................................................................................................... 3 Paediatric Sepsis ............................................................................................................................. 4 Community versus hospital acquired sepsis .................................................................................. 5 1.2.2. Microbiology ..................................................................................................................
    [Show full text]