Anti-ITGA2B; ITGB3 Monoclonal Antibody, Clone 348 (DCABH-9400) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-ITGA2B; ITGB3 monoclonal antibody, clone 348 (DCABH-9400) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse monoclonal to Integrin alpha 2b + beta 3

Antigen Description ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Specificity Under reducing conditions, this antibody will bind against the human platelet membrane glycoproteins IIb and/or IIIa, which have molecular weights of ~130,000 (IIb) and 115,000 (IIIa).

Immunogen 109 human platelet suspension. The supernatant fluid from postitive clones was screened via ELISA, the solid phase being coated with washed platelets.

Isotype IgG1

Source/Host Mouse

Species Reactivity Human

Clone 348

Purification Affinity purified from ascitic fluid.

Conjugate Unconjugated

Applications IP, WB

Format Liquid

Size 100 μg

Preservative None

Storage store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Ship Shipped at 4°C.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) [ Homo sapiens ]

Official Symbol ITGA2B

Synonyms ITGA2B; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); GP2B, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B); integrin alpha-IIb; CD41; CD41B; GPalpha IIb; platelet-specific antigen BAK

Entrez Gene ID 3674

Protein Refseq NP_000410

UniProt ID P08514

Chromosome Location 17q21.32

Pathway Arf6 signaling events, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem;

Function extracellular matrix binding; identical protein binding; protein binding; receptor activity;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]