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Liz Parrish Bill Andrews © 2016 All Rights Reserved 1 A cure for aging? www.sierrasci.comLiz Parrish Bill Andrews © 2016 All Rights Reserved. 2 Cellular Degeneration Underlies Biological Aging These are all symptoms of cellular Aging! Sarcopenia Arthritis Hypertension CANCER Alzheimer’s Disease Cellular Macular Degeneration Degeneration Cataracts Dementia Cardiovascular Atherosclerosis Diabetes disease Type 2 Nephropathy www.sierrasci.com © 2016 All Rights Reserved. 3 Increased Global Lifespan will Increase the Burden of the Diseases of Aging • By 2050 more older Young Children and Older People people than children as a percentage of global • More people at extreme population, % old age 20. 1004% Diseases of aging: 15. Heart 351% disease 10. Age Diabetes 188% Alzheimer’s <5 Cancer 5. others Age 65+ 85+ 0. 65+ 100+ 1950 1970 1990 2010 2030 2050 change in world`s 65+ population by 2050 www.sierrasci.com © 2016 All Rights Reserved. 4 Curing Aging www.sierrasci.com © 2016 All Rights Reserved. Telomeres 6 www.sierrasci.com © 2016 All Rights Reserved. 7 www.sierrasci.com © 2016 All Rights Reserved. 8 www.sierrasci.com © 2016 All Rights Reserved. 9 www.sierrasci.com © 2016 All Rights Reserved. 10 www.sierrasci.com © 2016 All Rights Reserved. 11 www.sierrasci.com © 2016 All Rights Reserved. 12 www.sierrasci.comSierra Sciences, LLC © 2016 All Rights Reserved. 13 www.sierrasci.com © 2016 All Rights Reserved. 14 www.sierrasci.com © 2016 All Rights Reserved. 15 www.sierrasci.com © 2016 All Rights Reserved. Telomere Shortening Diseases • AIDS • General Immunity • Alzheimer’s • Idiopathic Pulmonary Fibrosis • Aging • Liver Cirrhosis • Cancer • Macular Degeneration • Cardiovascular • Muscular Dystrophy • Cell & Tissue Transplants • Osteoarthritis • COPD • Osteoporosis • Cri du Chat syndrome • Progeria • Degenerative Disc Disease • Rheumatoid Arthritis • Down’s Syndrome • Skin Aging • Dyskeratosis Congenita • Tuberous Sclerosis • Fanconi’s Anemia • Werner’s Syndrome 17 Why telomeres shorten www.sierrasci.com © 2016 All Rights Reserved. 18 Why telomeres shorten www.sierrasci.com © 2016 All Rights Reserved. 19 Why telomeres shorten www.sierrasci.com © 2016 All Rights Reserved. 20 Why telomeres shorten www.sierrasci.com © 2016 All Rights Reserved. 21 Why telomeres shorten www.sierrasci.com © 2016 All Rights Reserved. 22 Basal level telomere shortening www.sierrasci.com © 2016 All Rights Reserved. 23 www.sierrasci.com © 2016 All Rights Reserved. 24 Accelerated telomere shortening www.sierrasci.com © 2016 All Rights Reserved. Telomerase Lengthens Telomeres 25 TELOMERE TELOMERASE www.sierrasci.com © 2016 All Rights Reserved. 26 www.sierrasci.com © 2016 All Rights Reserved. 27 www.sierrasci.com © 2016 All Rights Reserved. 28 Tug of War SHORTENERS LENGTHENERS 29 Normal SHORTENERS LENGTHENERS 30 Protecting Telomeres SHORTENERS LENGTHENERS 31 Add Lengtheners SHORTENERS LENGTHENERS 32 Add More Lengtheners Not Yet SHORTENERS LENGTHENERS 33 And Even More Lengtheners Gene therapy SHORTENERS LENGTHENERS 34 Gene therapy 1. Extended the Hayflick Limit! 2. Reversed aging in human tissue! 3. Reversed aging in mice 4. Telomeres control the other theories! Nothing else has ever done this! www.sierrasci.com © 2016 All Rights Reserved. Gene Therapy 36 Gene Therapy Chase Life BioViva Sierra Extension Sciences Foundation www.sierrasci.com © 2016 All Rights Reserved. 38 Gene Therapy Raising Millions of Dollars www.sierrasci.com © 2016 All Rights Reserved. Telomerase and Cancer No Clinical Data! Telomerase and Cancer For every study that suggests that telomerase might cause cancer, there are 100 studies that show that “lack of telomerase” does cause cancer The Most Important Currency is Time What Will You do With Yours? What Will You do With Yours? To Learn More 43 Available on Amazon.com 44 Available on iTunes, Netflix, etc. BioViva-Science.com Sierrasci.com .
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