1 A cure for aging?

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Cellular Degeneration Underlies Biological Aging These are all symptoms of cellular Aging! Sarcopenia Arthritis

Hypertension CANCER

Alzheimer’s Disease Cellular Macular Degeneration Degeneration Cataracts Dementia

Cardiovascular Atherosclerosis Diabetes disease Type 2 Nephropathy

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Increased Global Lifespan will Increase the Burden of the Diseases of Aging

• By 2050 more older Young Children and Older People people than children as a percentage of global • More people at extreme population, % old age 20. 1004% Diseases of aging: 15. Heart 351% disease 10. Age Diabetes 188% Alzheimer’s <5 Cancer 5. others Age 65+ 85+ 0. 65+ 100+ 1950 1970 1990 2010 2030 2050 change in world`s 65+ population by 2050

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Curing Aging

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www.sierrasci.com © 2016 All Rights Reserved. Shortening Diseases

• AIDS • General Immunity • Alzheimer’s • Idiopathic Pulmonary Fibrosis • Aging • Liver Cirrhosis • Cancer • Macular Degeneration • Cardiovascular • Muscular Dystrophy • Cell & Tissue Transplants • Osteoarthritis • COPD • Osteoporosis • Cri du Chat syndrome • Progeria • Degenerative Disc Disease • Rheumatoid Arthritis • Down’s Syndrome • Skin Aging • Dyskeratosis Congenita • Tuberous Sclerosis • Fanconi’s Anemia • Werner’s Syndrome 17 Why telomeres shorten

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www.sierrasci.com © 2016 All Rights Reserved. 19 Why telomeres shorten

www.sierrasci.com © 2016 All Rights Reserved. 20 Why telomeres shorten

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Basal level telomere shortening

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Accelerated telomere shortening

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TELOMERE

TELOMERASE www.sierrasci.com © 2016 All Rights Reserved. 26

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SHORTENERS LENGTHENERS 29 Normal

SHORTENERS LENGTHENERS 30 Protecting Telomeres

SHORTENERS LENGTHENERS 31 Add Lengtheners

SHORTENERS LENGTHENERS 32 Add More Lengtheners

Not Yet

SHORTENERS LENGTHENERS 33 And Even More Lengtheners

Gene therapy

SHORTENERS LENGTHENERS 34

1. Extended the Hayflick Limit! 2. Reversed aging in human tissue! 3. Reversed aging in mice 4. Telomeres control the other theories!

Nothing else has ever done this!

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Chase Life BioViva Sierra Extension Sciences Foundation

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Gene Therapy Raising Millions of Dollars

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No Clinical Data! Telomerase and Cancer

For every study that suggests that telomerase might cause cancer, there are 100 studies that show that “lack of telomerase” does cause cancer The Most Important Currency is Time

What Will You do With Yours?

What Will You do With Yours? To Learn More 43 Available on Amazon.com 44 Available on iTunes, Netflix, etc. BioViva-Science.com Sierrasci.com