A Scientifically Proven Cure for Aging
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Why We Age ... and the Science Behind it Copyrighted: ONE TRUTH Australia Pty Ltd For further information and to get the latest information on this technology, go to www.onetruth818.com.au Introduction – The Quest It’s 2009, Reno, Nevada. Dr. Bill Andrews stood wide-eyed with wonder. With his tall, ultra- marathon runner's frame bent over the instruments and computer screens inside his obscure laboratory, he and his team of fellow scientists checked and re-checked their extraordinary readings. The computers were not lying. They had indeed 'hit the jackpot’, or, at the very least, reached an extraordinary beacon in Andrew’s quest for the 'holy grail' - a real, proven cure for aging. That day, the PhD in Molecular Biology stood staring at the 314,818th molecule his laboratory had tested in the search for a compound that would slow down the human aging process. He marveled at the fact that the new molecule was three hundred times more powerful in stopping human aging than anything yet known to science. Little knowing that his life was about to change drastically due to this miraculous little unit, Andrews named it ‘CO314818’. George Bernard Shaw famously said: “Youth is wasted on the young”. This becomes true for most people in their late 30s and older, when the body’s messages of steady decline become only too apparent - deep lines, sagging, looser skin, ‘crow’s feet’ around the eyes. Usually the quest to halt this process starts in earnest now, often without sparing costs on surgical procedures and cosmetic products. Unfortunately for the consumer, keeping up with the Kardashians is lucrative business - there’s much money to be made off people’s insecurities. According to the International Society of Aesthetic Plastic Surgery, in 2016 this figure topped $16 billion in the USA. Equally unfortunately, many of these cosmetic procedures and products offer temporary to insignificant results, at best covering up the symptoms of aging for a while. The cause of skin aging is not addressed, and, till fairly recently, this was generally accepted as an impossible feat. However, a couple of key players, William (Bill) Andrews and Rachael D’Aguiar, and their respective teams changed this narrative: first through Bill’s remarkable discovery that also shed more light on how humans age, and then through the development of a revolutionary new skin product. For the last 25 years or so, the often-featured and interviewed Andrews knew in his heart that science would find answers to the questions humans had been asking throughout time: “Why do we age? And how do we stop aging?” "It seems ridiculous to some," Andrews acknowledged in an interview, "to even question the aging process. But before the Wright brothers, people thought it ridiculous that man dreamed of being able to fly. Before Galileo, Flat Earthers ruled the world. Arthur C. Clarke was ridiculed in some quarters when, in the 1940s, he predicted space travel and satellite communications." In short, what is inconceivable to one generation is achievable for the next. That day in Reno, bent over his discovery, Andrews knew he was on the cusp of achieving the inconceivable - to find an antidote for aging. But just a few grams of this remarkable new molecule would cost $50,000. How could it ever be used affordably? Yet, that’s the story - how a powerful molecule found its way into commercially-available products and how it is revolutionizing skincare - OneTruth 818 skin serum being the first. And it is indeed a story worth telling. A Short History One could say the story started with, inter alia, Nobel prize winning studies in cellular and molecular biology to find a cure for aging long before Andrews and D’Aguiar were born. Eventually it would boil down to a few processes and components: cell division, DNA replication, gene expression, telomeres and telomerase. But first, a look at the history and progression of important cellular and molecular discoveries that form the background to this story:1,2 * 1938: Telomere biology commences with Herman Muller. Working with the chromosomes of fruit flies, his test results lead him to conclude that the end of the chromosome is a “discrete structure that is essential for chromosome stability”3. He coins the structure telomere, after Greek ‘telos’ (end) and ‘meros’ (part). ! Dr. Herman Muller Image: Wikipedia *1940: Barbara McClintoch similarly concludes, through her studies on maize chromosomes, that telomeres have a protective function (telomere capping) that keeps chromosomes from fusing with each other and, in this way, prevents genetic mutation. ! Dr. Barbara McClintoch Image: Wikipedia Muller and McClintoch both won Nobel Prizes in 1948 and 1983 respectively, but not for their telomere studies. * Circa 1960: James Watson, DNA researcher and Nobel Prize winner (1962), becomes the first to suggest another function for telomeres – promoting complete DNA replication via a non-standard mechanism. * * 1961: Leonard Hayflick found the inherent limit to the number of times a human cell could divide in a petri dish to be 50 to 70. ! Dr. Leonard Hay flick Listen to Dr Hayflick Talk about his discovery Transcript And activities then centred on the chromosomal characterisation of the cells, because it was by this time learned that as the cells approached their… their limited capacity to replicate, a state that I call ‘Phase three’ – I described the lineage of these cell populations as phase one, which is the period of the primary culture, phase two is the 40 or so period where the cells are actively dividing, and phase three is a period when the cells have stopped dividing. People generally have called phase three the ‘Hayflick Limit’; perhaps I should say a word about the derivation of that term. The derivation occurred in the mid-’60s by a gentleman well-known in the scientific field, at least that time, Sir Macfarlane Burnet, an Australian Nobel Prize laureate who knew about my work and, indeed, made a visit to the Wistar Institute to see Hilary at one time and I was introduced to him then. He went on to write books in several fields outside of the one that he was expert in, which, namely, immunology, and he did a book in which he discussed aging. And in that book, he called what I had observed the ‘Hayflick Limit’, which is the origin of that term. So, I have Sir Macfarlane Burnet to either thank or not for the use of that term. *1971: Alexei Olovnikov, discovered that telomere shortening was the reason for the Hayflick limit. *1980: Elizabeth Blackburn, a Yale biologist, and Jack Szostak, a Harvard geneticist, proved that yeast was able to re-lengthen its telomeres. Over Christmas in 1984, Blackburn and her student, Carol Greider, discovered telomerase and, with Szostak, won the 2009 Nobel Prize in Medicine. Together, Blackburn, Szostak and Greider basically “discovered how chromosomes can be properly copied during cell division, and how they are protected from degradation by a highly conserved, telomeric DNA sequence” (telomerase) in the protozoa Tetrahymena.4 Dr. Elizabeth Blackburn ! Prof. Carol Greider Images: Wikipedia *1993 – 1997: William Andrews discovers the RNA component of human telomerase and its protein component. He also forms part of the team that discovers the protein component of telomerase, which results in a major breakthrough in telomere biology. ! Dr Bill Andrews, PhD More About Dr Bill Andrews How Do Humans Age? It’s almost inconceivable, but till a few decades ago, scientists were still only speculating about the exact mechanisms of human aging. Fortunately, in the USA a boy’s passion was ignited when his father suggested he become a doctor to find the cure for aging. The boy was only 10 years old, but this moment would change medical history. William (Bill) Henry Andrews was born on December 10, 1951, one of twin boys. His father’s comment made such an impression that he grew up to qualify himself in molecular biology and gerontology. “I just want to find a cure for aging,” would become Dr. Bill Andrews (PhD)’s mission and mantra. Not only does he himself not want to die of old age, but both his father and twin brother suffer from severe Alzheimer’s disease. Through biotechnology that could turn back the clock on human cellular aging, the possibility of curing Alzheimer’s and most age-related diseases is very real. So, with this very personal stake in finding a cure for aging, Andrews has spent the past 24 years tirelessly researching and working to realise this possibility. Part of his mission is educating the public and investors about the research. In his many talks and presentations, he skillfully unravels dense information as to how and why humans age, and explains his groundbreaking discoveries towards finding a cure. Drawing from his lectures, let’s first get some human cellular biology straight. Cells, Nuclei, Chromosomes and Genes: If one were to zoom in on a human body with a powerful microscope, it would become clear that the person’s body is made up of trillions of cells. Zoom in further, and it would be seen that each cell contains a nucleus, and inside the nuclei are the two- legged chromosomes with genes. Andrews elaborates: “Chromosomes are where our genes are. They give us our unique attributes like hair color, eye color, length etc. etc. Genes are organized on a molecule called DNA, like a long string of beads. The beads are called ‘bases’, and a typical DNA strand is about one hundred million bases in length.” The DNA strand lies curled up like a slinky from one end of the chromosome to the other.