The Silvers Series VI
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Looking Forward: Long-Term Perspectives on Recovery, Risk-Reduction, and Research
Looking forward: Long-term Perspectives on Recovery, Risk-Reduction, and Research Kim A. Gorgens, Ph.D., ABPP Graduate School of Professional Psychology/GSPP [email protected] @bubblewrapbrain •Chronic Symptom Management (Recovery) •Aging with a Vulnerable Brain (Risk-Reduction) •Emerging Technologies (Research) Mounting Evidence for a Lifetime of Change • “The propensity for experience dependent plasticity throughout life can be more or less potentiated by diverse factors including individual genetic, cellular, molecular, and environmental differences. These findings have lead us to understand that the rules that regulate plasticity are not only more intrinsically variable than were previously thought, but can also be shaped in mature brains.” • “As with many medical and health related fields where personalized and precision medicine are increasingly becoming mainstream, neurotherapeutic interventions targeting mechanisms of plasticity and cognition should also follow an individualized approach by harnessing individual differences to best utilize the brain’s innate capacity to change.” • See Patrice Voss, Maryse E. Thomas, J. Miguel Cisneros-Franco, & Étienne de Villers-Sidani. (2017). Dynamic Brains and the Changing Rules of Neuroplasticity: Implications for Learning and Recovery. Frontiers in Psychology, 8. A Trio of Challenges Post-Traumatic Headaches (PTH or PTHA) • Chronic post-traumatic headache=12+ months after injury • Rates reach up to 95% • 71% after moderate/severe TBI and 91% after mild TBI (mTBI) at 1 year (Lucas, -
Use Style: Paper Title
Volume 3, Issue 10, October – 2018 International Journal of Innovative Science and ResearchTechnology ISSN No:-2456-2165 How Blockchain can be used for Digitization of Human Consciousness Alastair Smith MS in Artificial Intelligence, Northwestern University New York, United States Abstract:- This article presents empirical evidence "sleep" of death, or bringing the bodies back to life and then collected from experts and professionals in the field of transferring them the memory downloaded. Recently the news digitization of minds and virtual reality about the potential has been spread that the American start-up Nectome has role that blockchain technology could play in the started a project of cryopreservation to the mind, waiting for digitization of human consciousness. The results of the the scientists to develop a system to digitize the thoughts and survey and secondary research indicate that blockchain recreate them on the computer. But in order for the technology can be used to enhance the security and privacy metamorphosis to succeed, the process must begin when the of digitized minds. The study shows evidence with brain is still alive, or at most a few minutes after death. supported arguments to the role that blockchain Around 25 people have already booked for the procedure [1]. technology could play in terms of prevention of attacks, data integrity, availability, confidentiality, operational B. Mind uploading, the biological brain mapped and copied security and privacy. The transfer of the mind or brain emulation is the project that involves the hypothetical process of transferring or Keywords:- Digitization of human consciousness,Blockchain copying a conscious mind from a brain to a non-biological technology; Security; Privacy; substrate. -
Lengthened Telomeres Restore Immune System to a Younger State
Dear friend, you are presumably here to find out more information on TA-65 telomeres and telomerase. This page contains just a small amount of what I have written about the topics but, many times the questions I get are the same. Here you will find the answers to many of the more frequently asked questions that I could not cover on the TA-65 page. Please note: I kept many of them in “post format” as they were originally published on the internet. Lengthened telomeres restore immune system to a younger state New study is the first ever Peer-Reviewed Report of a Telomerase Activator taken by live humans. New York, NY (September 8, 2010) — A pioneering study published in the Rejuvenation Research Journal today shows that TA-65, a natural Telomerase Activator made and marketed by Telomerase Activation Sciences, Inc. (“T.A. Sciences”), reduces the percentage of short telomeres in immune cells and restores and remodels the aging human immune system to be more like that of a younger individual. The year-long study of the first 100 clients of T.A. Sciences found that TA-65, a nutritional supplement marketed only through specialized doctors, had been successful in lengthening shortened telomeres. Telomeres are sequences of DNA, located at the ends of all chromosomes, which serve as cellular clocks of aging. Every time a cell divides, telomeres shorten until they become critically short, and the cell either stops functioning properly or dies. By activating a gene that is normally turned off, TA-65 has been shown to activate the enzyme telomerase. -
Vascular Tissue Challenge Official Rules Updated 2019-08-14
Vascular Tissue Challenge Official Rules Updated 2019-08-14 SECTION 1: Executive Summary 2 SECTION 2: Definitions & Assumptions 3 SECTION 3: Evaluation Criteria 3 SECTION 4: Safety & Care 5 SECTION 5: Registration Requirements 5 SECTION 6: Judging 6 SECTION 7: Timeline 8 SECTION 8: Eligibility, Disqualification, & Appeal 9 SECTION 9: Awards 10 The Methuselah Foundation Vascular Tissue Challenge Rules Page 1 SECTION 1: EXECUTIVE SUMMARY Objectives Summary The Vascular Tissue Challenge (hereafter “Challenge”) is a $500,000 prize purse to be divided among the first three teams who can successfully create thick, human vascularized organ tissue in an in-vitro environment while maintaining metabolic functionality similar to their in vivo native cells throughout a 30 calendar day survival period. NASA’s objective for this Challenge is to produce technologies capable of creating viable thick (>1cm) metabolic tissues that can be used to advance research on human physiology, fundamental space biology, and medicine taking place both on the Earth and the ISS National Laboratory. Specifically, technology innovations may enable the growth of de novo tissues and organs on orbit which may address the risks related to traumatic bodily injury, improve general crew health, and enhance crew performance on future, long-duration missions. Evaluation Criteria Summary Produce an in vitro vascularized tissue that is > 1 centimeter in thickness in all dimensions at the launch of the trial and maintains >85% survival of the required parenchymal cells throughout a 30 calendar day period. Tissues must provide adequate blood perfusion without uncontrolled leakage into the bulk tissue to maintain metabolic functionality similar to their in vivo native cells. -
Business Plan Reverse Aging Through Telomere Lengthening Contents
Business Plan Reverse Aging Through Telomere Lengthening Contents Road Map Expectation 24 Business Summary 3 TAM Clinical Studies 14 Requested Investment 25 Company 4 Our Research Team 5, 6 Defytime Bill Andrews Cosmeceutical Estimated Sales 24,25,26,27,28,29,30 Telomeres 7 Telomerase 8 Aging Care Capsules 15 Defytime Aging Care Cream 16 Non-medicated Item Estimated Sales 31, 32 What is Aging? 9 Defytime Eye Serum 17 Cash Flow Analysis Assumptions 33 Causes & Treatment of Aging 10 - Telomerase InductionAnti Aging Therapeutic Defytime Deep Skin Express 18 About Nano-bubble Clinic 34 11 Defytime Aqua Oil Drops 19 Nano-bubble Clinic Estimated Sales 35 - Telomerase Induction Defytime TAM Spray 20 Defytime Estimated Sales 36 Nano Bubbled Solution 12 Defytime Facial Mask 21 Defytime Limited Valuation 37, 38 TAM CO314818 13 Brand Marketing Strategy 22 Company & Brand Structure 39 SWOT Analysis 23 Proposed Summary Terms 40 Company Structure 41 Business Plan 2 Business Summary We have developed a genuine Our objectives are: anti aging solution called TAM • To create products with TAM (Telomerase Activating Molecule) as an active ingredient We now have a range of anti aging • To launch non-medicated and skin care products to introduce to the cosmetic market products: aging care capsule, oral spray and dermal products • VVIP anti aging tour business • To create telomere lengthening oral & dermal products for anti aging, aging care, and sell Defytime products through high end sales channels • To develop further premium anti aging products with TAM and non-medicated products • South Pacific & NZ Clinic could provide genuine anti aging services to VVIP anti aging tour groups Business Plan 3 Company Defytime Ltd is headquartered in Auckland New Zealand, with labs research and development in Reno, Nevada USA Our goal is to reverse the human aging process and cure diseases linked to aging by activating telomerase and thus extending telomeres, leading the cells to return to a state of youthful gene expression and function This cutting-edge research is led by Dr. -
Between Ape and Artilect Createspace V2
Between Ape and Artilect Conversations with Pioneers of Artificial General Intelligence and Other Transformative Technologies Interviews Conducted and Edited by Ben Goertzel This work is offered under the following license terms: Creative Commons: Attribution-NonCommercial-NoDerivs 3.0 Unported (CC-BY-NC-ND-3.0) See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details Copyright © 2013 Ben Goertzel All rights reserved. ISBN: ISBN-13: “Man is a rope stretched between the animal and the Superman – a rope over an abyss.” -- Friedrich Nietzsche, Thus Spake Zarathustra Table&of&Contents& Introduction ........................................................................................................ 7! Itamar Arel: AGI via Deep Learning ................................................................. 11! Pei Wang: What Do You Mean by “AI”? .......................................................... 23! Joscha Bach: Understanding the Mind ........................................................... 39! Hugo DeGaris: Will There be Cyborgs? .......................................................... 51! DeGaris Interviews Goertzel: Seeking the Sputnik of AGI .............................. 61! Linas Vepstas: AGI, Open Source and Our Economic Future ........................ 89! Joel Pitt: The Benefits of Open Source for AGI ............................................ 101! Randal Koene: Substrate-Independent Minds .............................................. 107! João Pedro de Magalhães: Ending Aging .................................................... -
From Here to Immortality: Anti-Aging Medicine
FromFrom HereHere toto Immortality:Immortaalitty: AAnti-AgingAnnntti-AAgging MMedicineedicine Anti-aging medicine is a $5 billion industry. Despite its critics, researchers are discovering that inter ventions designed to turn back time may prove to be more science than fiction. By Trudie Mitschang 14 BioSupply Trends Quarterly • October 2013 he symptoms are disturbing. Weight gain, muscle Shifting Attitudes Fuel a Booming Industry aches, fatigue and joint stiffness. Some experience The notion that aging requires treatment is based on a belief Thear ing loss and diminished eyesight. In time, both that becoming old is both undesirable and unattractive. In the memory and libido will lapse, while sagging skin and inconti - last several decades, aging has become synonymous with nence may also become problematic. It is a malady that begins dete rioration, while youth is increasingly revered and in one’s late 40 s, and currently 100 percent of baby boomers admired. Anti-aging medicine is a relatively new but thriving suffer from it. No one is immune and left untreated ; it always field driven by a baby- boomer generation fighting to preserve leads to death. A frightening new disease, virus or plague? No , its “forever young” façade. According to the market research it’s simply a fact of life , and it’s called aging. firm Global Industry Analysts, the boomer-fueled consumer The mythical fountain of youth has long been the subject of base will push the U.S. market for anti-aging products from folklore, and although it is both natural and inevitable, human about $80 billion now to more than $114 billion by 2015. -
SENS-Research-Foundation-2019
by the year 2050, cardiovascular an estimated 25-30 the american 85 percent of adults disease years and older age 85 or older remains the most population will suffer from common cause of 2 1 2 dementia. death in older adults. triple. THE CLOCK IS TICKING. By 2030, annual direct The estimated cost of medical costs associated dementia worldwide was 62% of Americans with cardiovascular $818 billion diseases in the united over age 65 have in 2015 and is states are expected to more than one expected to grow to rise to more than chronic condition.1 3 $2 trillion $818 billion. by 2030.1 References: (1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732407/, (2) https://www.who.int/ageing/publications/global_health.pdf, (3) https://www.cdcfoundation.org/pr/2015/heart-disease-and-stroke-cost-america-nearly-1-billion-day-medical-costs-lost-productivity sens research foundation board of directors Barbara Logan Kevin Perrott Bill Liao Chairperson Treasurer Secretary Michael Boocher Kevin Dewalt James O’Neill Jonathan Cain Michael Kope Frank Schuler 02 CONTENTS 2019 Annual Report 04 Letter From The CEO 06 Outreach & Fundraising 08 Finances 09 Donors erin ashford photography 14 Education 26 Investments 20 Conferences & Events 30 Research Advisory Board 23 Speaking Engagements 31 10 Years Of Research 24 Alliance 32 MitoSENS 34 LysoSENS 35 Extramural Research 38 Publications 39 Ways to Donate cover Photo (c) Mikhail Leonov - stock.adobe.com special 10th anniversary edition 03 FROM THE CEO It’s early 2009, and it’s very late at night. Aubrey, Jeff, Sarah, Kevin, and Mike are sitting around a large table covered in papers and half-empty food containers. -
1 of 16 SAA8-2032718 NONREIMBURSABLE SPACE ACT AGREEMENT BETWEEN the NATIONAL AERONAUTICS and SPACE ADMINISTRATION GEORGE
NONREIMBURSABLE SPACE ACT AGREEMENT BETWEEN THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GEORGE C. MARSHALL SPACE FLIGHT CENTER AND METHUSELAH FOUNDATION FOR THE CENTENNIAL CHALLENGES LUNAR NUTRITION CHALLENGE ARTICLE 1. AUTHORITY AND PARTIES In accordance with the National Aeronautics and Space Act (51 U.S.C. § 20113(e)), this Agreement is entered into by the National Aeronautics and Space Administration George C. Marshall Space Flight Center, located at Marshall Space Flight Center, AL 35812 (hereinafter referred to as "NASA" or "NASA MSFC") and Methuselah Foundation located at 8021 Flint Street, Springfield , VA 22153-2438 (hereinafter referred to as "Partner" or "MF"). NASA and Partner may be individually referred to as a "Party" and collectively referred to as the "Parties." ARTICLE 2. PURPOSE This Agreement shall be for the purpose of conducting the Lunar Nutrition Challenge for NASA Centennial Challenges program. This Challenge seeks to identify and foster the development and demonstration of novel technologies and/or approaches for food production for long duration space exploration missions. As part of the initial human presence on the Moon by 2024 and a sustainable human presence on the Moon by 2028, NASA's missions will become longer in duration and require sustainable systems that meet lunar crews' needs. This Challenge is focused on how to provide crew members with: • a viable food system for long duration missions • an approach that meets crew members' daily nutritional needs with limited resources • a palatable diet with limited or no dependency on Earth resupplies; and potentially a • ‘harvest' that provides a variety of food choices For the term of this Agreement, the Challenge will be developed and conducted by MF to foster these novel approaches to food production. -
Theory and Sociology in the Age of Fractal Ambiguity, Dromology, and Emergent Epi-Spaces
University of Tennessee, Knoxville TRACE: Tennessee Research and Creative Exchange Masters Theses Graduate School 5-2015 After the Human: Theory and Sociology in the Age of Fractal Ambiguity, Dromology, and Emergent Epi-spaces Joel Michael Crombez University of Tennessee - Knoxville, [email protected] Follow this and additional works at: https://trace.tennessee.edu/utk_gradthes Part of the Theory, Knowledge and Science Commons Recommended Citation Crombez, Joel Michael, "After the Human: Theory and Sociology in the Age of Fractal Ambiguity, Dromology, and Emergent Epi-spaces. " Master's Thesis, University of Tennessee, 2015. https://trace.tennessee.edu/utk_gradthes/3356 This Thesis is brought to you for free and open access by the Graduate School at TRACE: Tennessee Research and Creative Exchange. It has been accepted for inclusion in Masters Theses by an authorized administrator of TRACE: Tennessee Research and Creative Exchange. For more information, please contact [email protected]. To the Graduate Council: I am submitting herewith a thesis written by Joel Michael Crombez entitled "After the Human: Theory and Sociology in the Age of Fractal Ambiguity, Dromology, and Emergent Epi-spaces." I have examined the final electronic copy of this thesis for form and content and recommend that it be accepted in partial fulfillment of the equirr ements for the degree of Master of Arts, with a major in Sociology. Harry F. Dahms, Major Professor We have read this thesis and recommend its acceptance: Michelle Brown, Allen Dunn Accepted for the Council: Carolyn R. Hodges Vice Provost and Dean of the Graduate School (Original signatures are on file with official studentecor r ds.) After the Human: Theory and Sociology in the Age of Fractal Ambiguity, Dromology, and Emergent Epi-spaces A Thesis Presented for the Master of Arts Degree The University of Tennessee, Knoxville Joel Michael Crombez May 2015 Copyright © 2015 by Joel Michael Crombez All rights reserved. -
Exhibit B: Health Practitioner Magazine Advertisement
SUMMER 2011 ( HEALTHY AGING H l1st1c PnmaryCare 7 Telomerase Activation, Inhibition of Cellular Aging Becomes a Clinical Reality In 2009, Elizabeth Blackbum, Carol Greider, and amounts. if any at all In order to induce telomer telomerase on enough you might not only slow What's the ideal human telomere length? Jack Szostak established a cornerstone principle ase activity, one needs relatively large doses ofthe the aging process. you could potentially reverse ' The longer the better!' said Dr. Andrews. not of cell biology: cellular longevity is governed by purified compound This makes TA65, sold only it This has been demonstrated in mice but not ing that there are several ways to assess telo the length of telomeres, the DNA caps on the through healthcare professionals. an expensive yet In humans.' meres. The easiest way is to look at average ends of chromosomes. Telomere length, in turn, option. Geron, Dr. Andrews' old employer, is renew length in blood cells-a relatively inexpen Is regulated by an enzyme called telomerase. Alow dose protocol will cost roughly S1.200 ing Its search fortelomerase activators. Early in sive test available from Spectracell www. In short, when telomerase activity is high, so per 6-month period; the high dose protocol is 2010, the company published the first animal spectracell.com). But this will not tell you how is telomere length, and this delays cellular $4,000. TA Sciences estimates that approximately data on aproprietary compoundcalled"TATl 53,' short are the shortest telomeres. senescence.Articulation of this principle earned 2,0C,:, people are OON taking TA65.The company being developed as a drug for the treatment of Several labs, including Dr. -
321444 1 En Bookbackmatter 533..564
Index 1 Abdominal aortic aneurysm, 123 10,000 Year Clock, 126 Abraham, 55, 92, 122 127.0.0.1, 100 Abrahamic religion, 53, 71, 73 Abundance, 483 2 Academy award, 80, 94 2001: A Space Odyssey, 154, 493 Academy of Philadelphia, 30 2004 Vital Progress Summit, 482 Accelerated Math, 385 2008 U.S. Presidential Election, 257 Access point, 306 2011 Egyptian revolution, 35 ACE. See artificial conversational entity 2011 State of the Union Address, 4 Acquired immune deficiency syndrome, 135, 2012 Black Hat security conference, 27 156 2012 U.S. Presidential Election, 257 Acxiom, 244 2014 Lok Sabha election, 256 Adam, 57, 121, 122 2016 Google I/O, 13, 155 Adams, Douglas, 95, 169 2016 State of the Union, 28 Adam Smith Institute, 493 2045 Initiative, 167 ADD. See Attention-Deficit Disorder 24 (TV Series), 66 Ad extension, 230 2M Companies, 118 Ad group, 219 Adiabatic quantum optimization, 170 3 Adichie, Chimamanda Ngozi, 21 3D bioprinting, 152 Adobe, 30 3M Cloud Library, 327 Adonis, 84 Adultery, 85, 89 4 Advanced Research Projects Agency Network, 401K, 57 38 42, 169 Advice to a Young Tradesman, 128 42-line Bible, 169 Adwaita, 131 AdWords campaign, 214 6 Affordable Care Act, 140 68th Street School, 358 Afghan Peace Volunteers, 22 Africa, 20 9 AGI. See Artificial General Intelligence 9/11 terrorist attacks, 69 Aging, 153 Aging disease, 118 A Aging process, 131 Aalborg University, 89 Agora (film), 65 Aaron Diamond AIDS Research Center, 135 Agriculture, 402 AbbVie, 118 Ahmad, Wasil, 66 ABC 20/20, 79 AI. See artificial intelligence © Springer Science+Business Media New York 2016 533 N.