A Cure for Aging?
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Lengthened Telomeres Restore Immune System to a Younger State
Dear friend, you are presumably here to find out more information on TA-65 telomeres and telomerase. This page contains just a small amount of what I have written about the topics but, many times the questions I get are the same. Here you will find the answers to many of the more frequently asked questions that I could not cover on the TA-65 page. Please note: I kept many of them in “post format” as they were originally published on the internet. Lengthened telomeres restore immune system to a younger state New study is the first ever Peer-Reviewed Report of a Telomerase Activator taken by live humans. New York, NY (September 8, 2010) — A pioneering study published in the Rejuvenation Research Journal today shows that TA-65, a natural Telomerase Activator made and marketed by Telomerase Activation Sciences, Inc. (“T.A. Sciences”), reduces the percentage of short telomeres in immune cells and restores and remodels the aging human immune system to be more like that of a younger individual. The year-long study of the first 100 clients of T.A. Sciences found that TA-65, a nutritional supplement marketed only through specialized doctors, had been successful in lengthening shortened telomeres. Telomeres are sequences of DNA, located at the ends of all chromosomes, which serve as cellular clocks of aging. Every time a cell divides, telomeres shorten until they become critically short, and the cell either stops functioning properly or dies. By activating a gene that is normally turned off, TA-65 has been shown to activate the enzyme telomerase. -
Business Plan Reverse Aging Through Telomere Lengthening Contents
Business Plan Reverse Aging Through Telomere Lengthening Contents Road Map Expectation 24 Business Summary 3 TAM Clinical Studies 14 Requested Investment 25 Company 4 Our Research Team 5, 6 Defytime Bill Andrews Cosmeceutical Estimated Sales 24,25,26,27,28,29,30 Telomeres 7 Telomerase 8 Aging Care Capsules 15 Defytime Aging Care Cream 16 Non-medicated Item Estimated Sales 31, 32 What is Aging? 9 Defytime Eye Serum 17 Cash Flow Analysis Assumptions 33 Causes & Treatment of Aging 10 - Telomerase InductionAnti Aging Therapeutic Defytime Deep Skin Express 18 About Nano-bubble Clinic 34 11 Defytime Aqua Oil Drops 19 Nano-bubble Clinic Estimated Sales 35 - Telomerase Induction Defytime TAM Spray 20 Defytime Estimated Sales 36 Nano Bubbled Solution 12 Defytime Facial Mask 21 Defytime Limited Valuation 37, 38 TAM CO314818 13 Brand Marketing Strategy 22 Company & Brand Structure 39 SWOT Analysis 23 Proposed Summary Terms 40 Company Structure 41 Business Plan 2 Business Summary We have developed a genuine Our objectives are: anti aging solution called TAM • To create products with TAM (Telomerase Activating Molecule) as an active ingredient We now have a range of anti aging • To launch non-medicated and skin care products to introduce to the cosmetic market products: aging care capsule, oral spray and dermal products • VVIP anti aging tour business • To create telomere lengthening oral & dermal products for anti aging, aging care, and sell Defytime products through high end sales channels • To develop further premium anti aging products with TAM and non-medicated products • South Pacific & NZ Clinic could provide genuine anti aging services to VVIP anti aging tour groups Business Plan 3 Company Defytime Ltd is headquartered in Auckland New Zealand, with labs research and development in Reno, Nevada USA Our goal is to reverse the human aging process and cure diseases linked to aging by activating telomerase and thus extending telomeres, leading the cells to return to a state of youthful gene expression and function This cutting-edge research is led by Dr. -
Exhibit B: Health Practitioner Magazine Advertisement
SUMMER 2011 ( HEALTHY AGING H l1st1c PnmaryCare 7 Telomerase Activation, Inhibition of Cellular Aging Becomes a Clinical Reality In 2009, Elizabeth Blackbum, Carol Greider, and amounts. if any at all In order to induce telomer telomerase on enough you might not only slow What's the ideal human telomere length? Jack Szostak established a cornerstone principle ase activity, one needs relatively large doses ofthe the aging process. you could potentially reverse ' The longer the better!' said Dr. Andrews. not of cell biology: cellular longevity is governed by purified compound This makes TA65, sold only it This has been demonstrated in mice but not ing that there are several ways to assess telo the length of telomeres, the DNA caps on the through healthcare professionals. an expensive yet In humans.' meres. The easiest way is to look at average ends of chromosomes. Telomere length, in turn, option. Geron, Dr. Andrews' old employer, is renew length in blood cells-a relatively inexpen Is regulated by an enzyme called telomerase. Alow dose protocol will cost roughly S1.200 ing Its search fortelomerase activators. Early in sive test available from Spectracell www. In short, when telomerase activity is high, so per 6-month period; the high dose protocol is 2010, the company published the first animal spectracell.com). But this will not tell you how is telomere length, and this delays cellular $4,000. TA Sciences estimates that approximately data on aproprietary compoundcalled"TATl 53,' short are the shortest telomeres. senescence.Articulation of this principle earned 2,0C,:, people are OON taking TA65.The company being developed as a drug for the treatment of Several labs, including Dr. -
321444 1 En Bookbackmatter 533..564
Index 1 Abdominal aortic aneurysm, 123 10,000 Year Clock, 126 Abraham, 55, 92, 122 127.0.0.1, 100 Abrahamic religion, 53, 71, 73 Abundance, 483 2 Academy award, 80, 94 2001: A Space Odyssey, 154, 493 Academy of Philadelphia, 30 2004 Vital Progress Summit, 482 Accelerated Math, 385 2008 U.S. Presidential Election, 257 Access point, 306 2011 Egyptian revolution, 35 ACE. See artificial conversational entity 2011 State of the Union Address, 4 Acquired immune deficiency syndrome, 135, 2012 Black Hat security conference, 27 156 2012 U.S. Presidential Election, 257 Acxiom, 244 2014 Lok Sabha election, 256 Adam, 57, 121, 122 2016 Google I/O, 13, 155 Adams, Douglas, 95, 169 2016 State of the Union, 28 Adam Smith Institute, 493 2045 Initiative, 167 ADD. See Attention-Deficit Disorder 24 (TV Series), 66 Ad extension, 230 2M Companies, 118 Ad group, 219 Adiabatic quantum optimization, 170 3 Adichie, Chimamanda Ngozi, 21 3D bioprinting, 152 Adobe, 30 3M Cloud Library, 327 Adonis, 84 Adultery, 85, 89 4 Advanced Research Projects Agency Network, 401K, 57 38 42, 169 Advice to a Young Tradesman, 128 42-line Bible, 169 Adwaita, 131 AdWords campaign, 214 6 Affordable Care Act, 140 68th Street School, 358 Afghan Peace Volunteers, 22 Africa, 20 9 AGI. See Artificial General Intelligence 9/11 terrorist attacks, 69 Aging, 153 Aging disease, 118 A Aging process, 131 Aalborg University, 89 Agora (film), 65 Aaron Diamond AIDS Research Center, 135 Agriculture, 402 AbbVie, 118 Ahmad, Wasil, 66 ABC 20/20, 79 AI. See artificial intelligence © Springer Science+Business Media New York 2016 533 N. -
Health Options Foreclosed: How the FDA Denies Americans the Benefits
Health Options Foreclosed How the FDA Denies Americans the Benefits of Medical Research Richard Williams, Marc Joffe, and Ariel Slonim September 2016 MERCATUS WORKING PAPER Richard Williams, Marc Joffe, and Ariel Slonim. “Health Options Foreclosed: How the FDA Denies Americans the Benefits of Medical Research.” Mercatus Working Paper, Mercatus Center at George Mason University, Arlington, VA, September 2016. Abstract In recent decades, the Food and Drug Administration (FDA) has assumed increasing premarket authority for drugs and devices. Given how the FDA’s regulatory stance has inhibited breakthroughs in the development of medical products, it appears that the agency will stand in the way of emerging technologies such as nanotechnology, synthetic biology, nanorobotics, virally delivered telomerase, and cellular therapy. These new technologies represent not only the means to prevent and cure diseases, but also the key to helping people live longer and healthier lives. We conclude, therefore, that an incremental approach to reform—one that would keep the FDA as the sole arbiter of new medical technologies—is unlikely to work. Rather, we think that a regulatory system based on competitive market approval of drugs and devices is more likely to strike the appropriate benefit-risk balance, including that inherent in the compassionate use of experimental medical treatments. JEL codes: H11, I18, L65 Keywords: FDA, regulation, drugs, biotechnology, pharmaceuticals Author Affiliation and Contact Information Richard Williams Director for the Regulatory Studies Program Mercatus Center at George Mason University [email protected] Marc Joffe Principal Consultant Public Sector Credit Solutions [email protected] Ariel Slonim MA Fellow, Mercatus Center All studies in the Mercatus Working Paper series have followed a rigorous process of academic evaluation, including (except where otherwise noted) at least one double-blind peer review. -
TERT Mrna for Telomere Extension to Treat Fatal Diseases and Aging
TERT mRNA for telomere extension to treat fatal diseases and aging Aging or disease TERT mRNA [email protected] Rejuvenation Technologies Inc. © 2021 Why aging? • Aging is the strongest risk factor for all age- related diseases • Telomeres are a cellular Deaths per 100,000per Deaths aging clock Age: • Telomere extension From: The Milbank Quarterly, Vol. 80 No. 1, 2002, from US 1997 Vital Statistics resets the aging clock 2 Prepared for Rejuvenation Tech Investors The road to healthspan extension Market Liver $30B Liver Cirrhosis, Alcoholic Hepatitis Lung • Safety & efficacy data $10B Interstitial Lung Disease including IPF • Capital Blood $10B Cytopenia, Neutropenia Whole body Clinical Trial Endpoints: • Improved function (6 months) $1T+ AGING • Delayed all-cause mortality (2 years) • Longer healthspan (Phase IV) 3 Prepared for Rejuvenation Tech Investors mRNA therapies have come of age Jan. 2020 Market caps Jan. 2021 • 2020 was the year mRNA worked Moderna $65B • $100B in value created $6B • We invented a way to reset the aging clock using mRNA BioNTech $27B • In 2020 we achieved proof-of- concept in mice $7B Translate Bio $1.9B • Series A to gain IND clearance for first-in-human studies $0.4B 4 Prepared for Rejuvenation Tech Investors Summary • TERT mRNA: our patented method to extend telomeres • One dose reverses a decade of telomere shortening • Lead indications: fatal diseases of liver and lung • TERT mRNA extends survival by 42% and reduces liver fibrosis by 25% in mice • First FDA meeting Q2 2021 5 Prepared for Rejuvenation -
Business Plan Reverse Aging Through Telomere Lengthening Contents
Business Plan Reverse Aging Through Telomere Lengthening Contents Road Map Expectation 24 Business Summary 3 TAM Clinical Studies 14 Requested Investment 25 Company 4 Our Research Team 5, 6 Defytime Bill Andrews Cosmeceutical Estimated Sales 24,25,26,27,28,29,30 Telomeres 7 Telomerase 8 Aging Care Capsules 15 Defytime Aging Care Cream 16 Non-medicated Item Estimated Sales 31, 32 What is Aging? 9 Defytime Eye Serum 17 Cash Flow Analysis Assumptions 33 Causes & Treatment of Aging 10 - Telomerase InductionAnti Aging Therapeutic Defytime Deep Skin Express 18 About Nano-bubble Clinic 34 11 Defytime Aqua Oil Drops 19 Nano-bubble Clinic Estimated Sales 35 - Telomerase Induction Defytime TAM Spray 20 Defytime Estimated Sales 36 Nano Bubbled Solution 12 Defytime Facial Mask 21 Defytime Limited Valuation 37, 38 TAM CO314818 13 Brand Marketing Strategy 22 Company & Brand Structure 39 SWOT Analysis 23 Proposed Summary Terms 40 Company Structure 41 Business Plan 2 Business Summary We have developed a genuine Our objectives are: anti aging solution called TAM • To create products with TAM (Telomerase Activating Molecule) as an active ingredient We now have a range of anti aging • To launch non-medicated and skin care products to introduce to the cosmetic market products: aging care capsule, oral spray and dermal products • VVIP anti aging tour business • To create telomere lengthening oral & dermal products for anti aging, aging care, and sell Defytime products through high end sales channels • To develop further premium anti aging products with TAM and non-medicated products • South Pacific & NZ Clinic could provide genuine anti aging services to VVIP anti aging tour groups Business Plan 3 Company Defytime Ltd is headquartered in Auckland New Zealand, with labs research and development in Reno, Nevada USA Our goal is to reverse the human aging process and cure diseases linked to aging by activating telomerase and thus extending telomeres, leading the cells to return to a state of youthful gene expression and function This cutting-edge research is led by Dr. -
El Transhumanisme Sota La Lupa Francesc Torralba, Coordinador Conferències Curs 2017-2018
El Transhumanisme sota la lupa Francesc Torralba, coordinador Conferències curs 2017-2018 T E H E M O C R L U B O F BARCELONA Francesc Torralba Roselló és filòsof i teòleg. Neix a Barcelona el 15 de maig de 1967. Casat i pare de 5 fills. Doctor en Filosofia per la Universitat de Barcelona (1992). Doctor en Teologia per la Facultat de Teologia de Catalunya (1997). Doctor en Pedagogia per la Universitat Ramon Llull (2018). Amplia estudis a les Universitats de Copenhaguen i Berlín. En l’actualitat és catedràtic acreditat a la Universitat Ramon Llull, i imparteix cursos i seminaris en altres universitats d’Espanya i d’Amèrica. Alterna la seva activitat docent amb l’ofici d’escriure, i divulgar el seu pensament. Francesc Torralba és un autor prolífic, amb més de 1.500 articles i 100 llibres publicats dels quals destaquem: "El sentit de la vida" (2008), Biblioteca Francesc Torralba dedicada a valors amb títols com "La Tendresa", "La Paciència" o "L'Amistat", (2008), "Inteligencia Espiritual" (2010), "Jesucrist 2.0" (2011), "El valor de tenir valors" (2012), "Un mar d'e- mocions" (2013), "Córrer per pensar i sentir" (2015), "Saber dir no" (2016) i "La vida secreta de la pregària" (2017). Part de la seva obra ha estat traduïda al castellà, l'a- lemany, el francès, l'italià, el portuguès, el romanès i l'anglès. ament. EL TRANSHUMANISME SOTA LA LUPA Conferències curs 2017-2018 Amb la col.laboració de: Disseny i impressió: Vanguard Gràfic, SA ÍNDEX Introducción, de Jaime Lanaspa . 5 ¿De què parlem quan parlem de transhumanisme?, de Francesc Torralba . -
Do Actuaries Believe in Longevity Deceleration? Edouard Debonneuil, Stéphane Loisel, Frédéric Planchet
Do actuaries believe in longevity deceleration? Edouard Debonneuil, Stéphane Loisel, Frédéric Planchet To cite this version: Edouard Debonneuil, Stéphane Loisel, Frédéric Planchet. Do actuaries believe in longevity decelera- tion?. 2015. hal-01219270v2 HAL Id: hal-01219270 https://hal.archives-ouvertes.fr/hal-01219270v2 Preprint submitted on 5 Aug 2017 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. DO ACTUARIES BELIEVE IN LONGEVITY DECELERATION? Edouard Debonneuil Stéphane Loisel Frédéric Planchet* Univ Lyon - Université Claude Bernard Lyon 1, ISFA, Laboratoire SAF EA2429, F-69366, Lyon, France Prim’Act, 42 avenue de la Grande Armée, 75017 Paris, France ActuRx Version 2.0 du 05/08/2017 ABSTRACT As more and more people believe that significant life extensions may come soon, should commonly used future mortality assumptions be considered prudent? We find here that commonly used actuarial tables for annuitants – as well as the Lee-Carter model – do not extrapolate life expectancy at the same rate for future years as for past years; instead they produce some longevity deceleration. This is typically because their mortality improvements decrease after a certain age, and those age-specific improvements are constant over time. -
Longevidad Y Envejecimiento En El Tercer Milenio: Nuevas Perspectivas
LONGEVIDAD Y ENVEJECIMIENTO EN EL TERCER MILENIO: NUEVAS PERSPECTIVAS JOSÉ MIGUEL RODRÍGUEZ-PARDO DEL CASTILLO ANTONIO LÓPEZ FARRÉ LONGEVIDAD Y ENVEJECIMIENTO EN EL TERCER MILENIO: NUEVAS PERSPECTIVAS José Miguel Rodríguez-Pardo del Castillo Profesor del Máster en Ciencias Actuariales y Financieras Universidad Carlos III, Madrid Antonio López Farré Profesor de la Facultad de Medicina. Departamento de Medicina. Codirector del Aula AINTEC Universidad Complutense de Madrid Fundación MAPFRE no se hace responsable del contenido de esta obra, ni el hecho de publicarla implica conformidad o identificación con las opiniones vertidas en ella. Reservados todos los derechos. Está prohibido reproducir o transmitir esta publicación, total o parcialmente, por cualquier medio, sin la autorización expresa de los editores, bajo las sanciones establecidas en las leyes. Imágenes de cubierta e interiores: ThinkStock Maquetación e impresión: Edipack Gráfico © De los textos: sus autores © De esta edición: 2017, Fundación MAPFRE Paseo de Recoletos, 23 28004 Madrid www.fundacionmapfre.org ISBN: 978-84-9844-648-7 Depósito Legal: M-18221-2017 «Los hombres son como los vinos: la edad agria los malos y mejora los buenos». Marco Tulio Cicerón «Solo la alegría es señal de salud y longevidad». Santiago Ramón y Cajal «No anheléis la inmortalidad, pero agotad el límite de lo posible». Píndaro Agradecimiento: Los autores quieren agradecer a Begoña Larrea Cruz su excelente y dedicada labor en la edición de esta obra, sin cuya ayuda no hubiera sido nunca finalizada. PRESENTACIÓN Desde 1975 Fundación MAPFRE desarrolla actividades de interés general para la sociedad en distintos ámbitos profesionales y culturales, así como ac- ciones destinadas a la mejora de las condiciones económicas y sociales de las personas y de los sectores menos favorecidos de la sociedad. -
Do Actuaries Believe in Longevity Deceleration?
Do actuaries believe in longevity deceleration? Edouard Debonneuil(*), Frédéric Planchet, Stéphane Loisel ISFA, Longevity 11, 2015 (*) [email protected] Do actuaries believe in longevity 1 deceleration? Longevity 11, ISFA 2015 Do actuaries believe in longevity deceleration? • Part I. Extrapolation of the past • Part II. Taking a prudent view Do actuaries believe in longevity deceleration? Longevity 11, ISFA 2015 2 Modeling a neutral view EXAMPLE OF BELIEF In the absence of belief of whether Youth pill life expectancy increase faster in the future (e.g. biomedical discoveries) or not (e.g. pollution) Virus would you, for a central longevity scenario, rather consider same/lower/higher mortality improvements than in the past? mortality improvements Do actuaries believe in longevity deceleration? Longevity 11, ISFA 2015 3 Historical evolutions of life expectancy • « +1 quarter per year » • Piecewise lines +23% Louis Pasteur Jim Oeppen and James Vaupel (2002) : Jacques Vallin and France Meslé (2010) : Espérance de vie: peut-on Broken Limits to Life Expectancy. Science 296 gagner trois mois par an indéfiniment ? Population & Sociétés 473 In a central scenario, and in the absence of country-specific context, should life expectancy rather increase by +{20-25}% year per year? less? more? Do actuaries believe in longevity deceleration? Longevity 11, ISFA 2015 4 Lee Carter uses the same mortality improvements for the future as in the past; does it lead to +23% per year? • Extract from the original paper: • “While many methods assume an upper limit to the human life span (…) our method allows (…) the deceleration of life expectancy (…) without any special additional assumptions.” Lee Ronald and Lawrence Carter (1992) : Journal of the American Statistical Association. -
William H Andrews
William H Andrews, J Yoga Phys Ther 2018, Volume 8 DOI: 10.4172/2157-7595-C1-001 4th World Chinese Medicine, Yoga & Mental Health Congress September 17-18, 2018 | San Diego, USA William H Andrews Sierra Sciences, USA I think, therefore i am young elomere lengths are rapidly becoming the best measure of aging that the field has ever seen. Telomeres are found at the Ttips of our chromosomes and have been shown to shorten as we age. Recent studies by my lab and others have shown that lengthening telomeres reverses aging and declining health in human cells grown in culture as well as in engineered mice. Treatments to lengthen telomeres in humans do not exist yet. In the meantime, studies suggest that slowing down the rate of telomere shortening slows down the rate of aging and extends human healthspan and lifespan. One of the most powerful ways to slow down the rate of telomere shortening has been shown in scientific peer-reviewed studies to be through yoga and meditation. The mechanism of action of mindfulness on the rate of telomere shortening is still being investigated, but I plan to describe the studies that have already been done and those that are in progress to show the strong correlation that exists. Mindfulness through yoga and meditation may be one of the best things we can do to stay young and healthy for as long as possible. Biography William H Andrews has worked in the biotech industry for 34 years focusing the last 22 years on finding ways to extend human lifespan through the intervention of telomere shortening in human cells.