Sources, Emission and Exposure for Trichloroethylene (Tce) and Related Chemicals

Total Page:16

File Type:pdf, Size:1020Kb

Sources, Emission and Exposure for Trichloroethylene (Tce) and Related Chemicals EPA/600/R-00/099 March 2001 SOURCES, EMISSION AND EXPOSURE FOR TRICHLOROETHYLENE (TCE) AND RELATED CHEMICALS National Center for Environmental Assessment–Washington Office Office of Research and Development U.S. Environmental Protection Agency Washington, DC 20460 DISCLAIMER This report has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. ii TABLE OF CONTENTS LIST OF TABLES............................................................ x LIST OF FIGURES........................................................... xi PREFACE ................................................................. xii AUTHORS, CONTRIBUTORS, AND REVIEWERS ............................... xiii SECTION A. SUMMARY AND INTRODUCTION ..................................1 SUMMARY..................................................................1 INTRODUCTION ............................................................10 SECTION B. PARENT COMPOUNDS ..........................................13 1.0 TRICHLOROETHYLENE ...............................................13 1.1 CHEMICAL AND PHYSICAL PROPERTIES .........................13 1.1.1 Nomenclature ..............................................13 1.1.2 Formula and Molecular Weight ................................13 1.1.3 Chemical and Physical Properties ..............................13 1.1.4 Technical Products and Impurities ..............................14 1.2 PRODUCTION AND USE .........................................14 1.2.1 Production ................................................14 1.2.2 Uses .....................................................14 1.2.3 Disposal ..................................................15 1.3 POTENTIAL FOR HUMAN EXPOSURE.............................15 1.3.1 Natural Occurrence .........................................15 1.3.2 Occupational Exposure ......................................15 1.3.3 Environmental .............................................15 1.4 HUMAN EXPOSURE AND POPULATION ESTIMATES ...............23 1.4.1 General U.S. Population .....................................23 1.4.2 Occupational Exposure ......................................26 1.4.3 Consumer Exposure .........................................27 1.5 CHAPTER SUMMARY...........................................27 2.0 TETRACHLOROETHYLENE (PERCHLOROETHYLENE) ....................30 2.1 CHEMICAL AND PHYSICAL PROPERTIES .........................30 2.1.1 Nomenclature ..............................................30 2.1.2 Formula and Molecular Weight ................................30 2.1.3 Chemical and Physical Properties ..............................30 2.1.4 Technical Products and Impurities ..............................31 2.2 PRODUCTION AND USE .........................................31 iii TABLE OF CONTENTS (continued) 2.2.1 Production ................................................31 2.2.2 Uses .....................................................32 2.2.3 Disposal ..................................................32 2.3 POTENTIAL FOR HUMAN EXPOSURE.............................32 2.3.1 Natural Occurrence .........................................32 2.3.2 Occupational ..............................................32 2.3.3 Environmental .............................................33 2.4 HUMAN EXPOSURE AND POPULATION ESTIMATES ...............40 2.4.1 General U.S. Population .....................................40 2.4.2 Occupational Exposure ......................................41 2.4.3 Consumer Exposure .........................................41 2.5 CHAPTER SUMMARY...........................................41 3.0 1,1,1-TRICHLOROETHANE (METHYL CHLOROFORM) .....................44 3.1 CHEMICAL AND PHYSICAL PROPERTIES .........................44 3.1.1 Nomenclature ..............................................44 3.1.2 Formula and Molecular Weight ................................44 3.1.3 Chemical and Physical Properties ..............................44 3.1.4 Technical Products and Impurities ..............................45 3.2 PRODUCTION AND USE .........................................45 3.2.1 Production ................................................45 3.2.2 Uses .....................................................46 3.2.3 Disposal ..................................................46 3.3 POTENTIAL FOR HUMAN EXPOSURE.............................46 3.3.1 Natural Occurrence .........................................46 3.3.2 Occupational ..............................................46 3.3.3 Environmental .............................................47 3.4 HUMAN EXPOSURE AND POPULATION ESTIMATES ...............52 3.4.1 General U.S. Population .....................................52 3.4.2 Occupational Exposure ......................................52 3.4.3 Consumer Exposure ........................................54 3.5 CHAPTER SUMMARY...........................................54 4.0 1,2-DICHLOROETHYLENE .............................................56 4.1 CHEMICAL AND PHYSICAL PROPERTIES .........................56 4.1.1 Nomenclature ..............................................56 4.1.2 Formula and Molecular Weight ................................56 4.1.3 Chemical and Physical Properties ..............................56 4.1.4 Technical Products and Impurities ..............................57 4.2 PRODUCTION AND USE .........................................57 4.2.1 Production ................................................57 4.2.2 Uses .....................................................57 4.2.3 Disposal ..................................................58 4.3 POTENTIAL FOR HUMAN EXPOSURE.............................58 iv TABLE OF CONTENTS (continued) 4.3.1 Natural Occurrence .........................................58 4.3.2 Occupational ..............................................58 4.3.3 Environmental .............................................58 4.4 HUMAN EXPOSURE AND POPULATION ESTIMATES ...............62 4.4.1 General U.S. Population .....................................62 4.4.2 Occupational Exposure ......................................62 4.4.3 Consumer Exposure .........................................64 4.5 CHAPTER SUMMARY...........................................64 5.0 CIS-1,2-DICHLOROETHYLENE .........................................65 5.1 CHEMICAL AND PHYSICAL PROPERTIES .........................65 5.1.1 Nomenclature ..............................................65 5.1.2 Formula and Molecular Weight ................................65 5.1.3 Chemical and Physical Properties ..............................65 5.1.4 Technical Products and Impurities ..............................66 5.2 PRODUCTION AND USE .........................................66 5.2.1 Production ................................................66 5.2.2 Uses .....................................................66 5.2.3 Disposal ..................................................67 5.3 POTENTIAL FOR HUMAN EXPOSURE.............................67 5.3.1 Natural Occurrence .........................................67 5.3.2 Occupational ..............................................67 5.3.3 Environmental .............................................67 5.4 HUMAN EXPOSURE AND POPULATION ESTIMATES ...............70 5.4.1 General U.S. Population .....................................70 5.4.2 Occupational Exposure ......................................70 5.4.3 Consumer Exposure .........................................70 6.0 TRANS-1,2-DICHLOROETHYLENE ......................................71 6.1 CHEMICAL AND PHYSICAL PROPERTIES .........................71 6.1.1 Nomenclature ..............................................71 6.1.2 Formula and Molecular Weight ................................71 6.1.3 Chemical and Physical Properties ..............................71 6.1.4 Technical Products and Impurities ..............................72 6.2 PRODUCTION AND USE .........................................72 6.2.1 Production ................................................72 6.2.2 Uses .....................................................72 6.2.3 Disposal ..................................................73 6.3 POTENTIAL FOR HUMAN EXPOSURE.............................73 6.3.1 Natural Occurrence .........................................73 6.3.2 Occupational ..............................................73 6.3.3 Environmental .............................................73 6.4 HUMAN EXPOSURE AND POPULATION ESTIMATES ...............76 6.4.1 General U.S. Population .....................................76 v TABLE OF CONTENTS (continued) 6.4.2 Occupational Exposure ......................................76 6.4.3 Consumer Exposure .........................................76 7.0 1,1,1,2-TETRACHLOROETHANE ........................................77 7.1 CHEMICAL AND PHYSICAL PROPERTIES .........................77 7.1.1 Nomenclature ..............................................77 7.1.2 Formula and Molecular Weight ................................77 7.1.3 Chemical and Physical Properties ..............................77 7.1.4 Technical Products and Impurities ..............................78 7.2 PRODUCTION AND USE .........................................78 7.2.1 Production ................................................78 7.2.2 Uses .....................................................78 7.2.3 Disposal ..................................................79 7.3 POTENTIAL FOR HUMAN EXPOSURE.............................79
Recommended publications
  • Title 16. Crimes and Offenses Chapter 13. Controlled Substances Article 1
    TITLE 16. CRIMES AND OFFENSES CHAPTER 13. CONTROLLED SUBSTANCES ARTICLE 1. GENERAL PROVISIONS § 16-13-1. Drug related objects (a) As used in this Code section, the term: (1) "Controlled substance" shall have the same meaning as defined in Article 2 of this chapter, relating to controlled substances. For the purposes of this Code section, the term "controlled substance" shall include marijuana as defined by paragraph (16) of Code Section 16-13-21. (2) "Dangerous drug" shall have the same meaning as defined in Article 3 of this chapter, relating to dangerous drugs. (3) "Drug related object" means any machine, instrument, tool, equipment, contrivance, or device which an average person would reasonably conclude is intended to be used for one or more of the following purposes: (A) To introduce into the human body any dangerous drug or controlled substance under circumstances in violation of the laws of this state; (B) To enhance the effect on the human body of any dangerous drug or controlled substance under circumstances in violation of the laws of this state; (C) To conceal any quantity of any dangerous drug or controlled substance under circumstances in violation of the laws of this state; or (D) To test the strength, effectiveness, or purity of any dangerous drug or controlled substance under circumstances in violation of the laws of this state. (4) "Knowingly" means having general knowledge that a machine, instrument, tool, item of equipment, contrivance, or device is a drug related object or having reasonable grounds to believe that any such object is or may, to an average person, appear to be a drug related object.
    [Show full text]
  • Pharmacological Treatments in Insomnia
    Pharmacological treatments in insomnia Sue Wilson Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College, London Drugs used in insomnia Licensed for insomnia •GABA-A positive allosteric modulators •melatonin (modified release) •promethazine •diphenhydramine •doxepin (USA) Unlicensed prescribed frequently •antihistamines (and OTC) •antidepressants Sometimes prescribed drugs for psychosis Some GABA-A positive allosteric modulators Drugs acting at the GABA-A benzodiazepine receptor zopiclone zolpidem zaleplon benzodiazepines eg temazepam, lorazepam (safe in overdose, as long as no other drug involved) Drugs acting at the barbiturate/alcohol receptor chloral hydrate/chloral betaine clomethiazole (dangerous in overdose) GABA calms the brain Gamma aminobutyic acid (GABA) is the main inhibitory transmitter in the mammalian central nervous system. It plays the principal role in reducing neuronal excitability and its receptors are prolific throughout the brain, in cortex, limbic system, thalamus and cerebellum sedative Increase anticonvulsant GABA anxiolytic function ataxia, memory effects Effects of GABA-A positive allosteric modulators •These drugs enhance the effect of GABA, the main inhibitory neurotransmitter in the brain •They all produce sedation, sleep promotion, ataxia, muscle relaxation, effects on memory, anticonvulsant effects •Therefore for insomnia the duration of action of the drug is important – these effects are unwanted during the day Effects of these GABA-ergic drugs on sleep EEG/PSG • Appearance of
    [Show full text]
  • 124.210 Schedule IV — Substances Included. 1
    1 CONTROLLED SUBSTANCES, §124.210 124.210 Schedule IV — substances included. 1. Schedule IV shall consist of the drugs and other substances, by whatever official name, common or usual name, chemical name, or brand name designated, listed in this section. 2. Narcotic drugs. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation containing any of the following narcotic drugs, or their salts calculated as the free anhydrous base or alkaloid, in limited quantities as set forth below: a. Not more than one milligram of difenoxin and not less than twenty-five micrograms of atropine sulfate per dosage unit. b. Dextropropoxyphene (alpha-(+)-4-dimethylamino-1,2-diphenyl-3-methyl-2- propionoxybutane). c. 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol, its salts, optical and geometric isomers and salts of these isomers (including tramadol). 3. Depressants. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances, including its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation: a. Alprazolam. b. Barbital. c. Bromazepam. d. Camazepam. e. Carisoprodol. f. Chloral betaine. g. Chloral hydrate. h. Chlordiazepoxide. i. Clobazam. j. Clonazepam. k. Clorazepate. l. Clotiazepam. m. Cloxazolam. n. Delorazepam. o. Diazepam. p. Dichloralphenazone. q. Estazolam. r. Ethchlorvynol. s. Ethinamate. t. Ethyl Loflazepate. u. Fludiazepam. v. Flunitrazepam. w. Flurazepam. x. Halazepam. y. Haloxazolam. z. Ketazolam. aa. Loprazolam. ab. Lorazepam. ac. Lormetazepam. ad. Mebutamate. ae. Medazepam. af. Meprobamate. ag. Methohexital. ah. Methylphenobarbital (mephobarbital).
    [Show full text]
  • Drug and Medication Classification Schedule
    KENTUCKY HORSE RACING COMMISSION UNIFORM DRUG, MEDICATION, AND SUBSTANCE CLASSIFICATION SCHEDULE KHRC 8-020-1 (11/2018) Class A drugs, medications, and substances are those (1) that have the highest potential to influence performance in the equine athlete, regardless of their approval by the United States Food and Drug Administration, or (2) that lack approval by the United States Food and Drug Administration but have pharmacologic effects similar to certain Class B drugs, medications, or substances that are approved by the United States Food and Drug Administration. Acecarbromal Bolasterone Cimaterol Divalproex Fluanisone Acetophenazine Boldione Citalopram Dixyrazine Fludiazepam Adinazolam Brimondine Cllibucaine Donepezil Flunitrazepam Alcuronium Bromazepam Clobazam Dopamine Fluopromazine Alfentanil Bromfenac Clocapramine Doxacurium Fluoresone Almotriptan Bromisovalum Clomethiazole Doxapram Fluoxetine Alphaprodine Bromocriptine Clomipramine Doxazosin Flupenthixol Alpidem Bromperidol Clonazepam Doxefazepam Flupirtine Alprazolam Brotizolam Clorazepate Doxepin Flurazepam Alprenolol Bufexamac Clormecaine Droperidol Fluspirilene Althesin Bupivacaine Clostebol Duloxetine Flutoprazepam Aminorex Buprenorphine Clothiapine Eletriptan Fluvoxamine Amisulpride Buspirone Clotiazepam Enalapril Formebolone Amitriptyline Bupropion Cloxazolam Enciprazine Fosinopril Amobarbital Butabartital Clozapine Endorphins Furzabol Amoxapine Butacaine Cobratoxin Enkephalins Galantamine Amperozide Butalbital Cocaine Ephedrine Gallamine Amphetamine Butanilicaine Codeine
    [Show full text]
  • 2015R3015 1 Senate Bill No. 458 2
    2015R3015 1 Senate Bill No. 458 2 (By Senators Stollings and Kessler) 3 ____________ 4 [Introduced February 11, 2015; referred to the Committee on Health and Human Resources; and 5 then to the Committee on the Judiciary.] 6 ____________ 7 8 9 10 A BILL to amend and reenact §60A-2-210 and §60A-2-212 of the Code of West Virginia, 1931, as 11 amended; and to amend and reenact §60A-10-2, §60A-10-4 and §60A-10-7 of said code, all 12 relating to controlling methamphetamine; requiring prescription to dispense drug products 13 that contain active ingredient ephedrine, pseudoephedrine, phenylpropanolamine and other 14 precursors of methamphetamine; moving certain drug products from Schedule V to Schedule 15 IV; providing exception for drug products that cannot be feasibly converted into 16 methamphetamine; defining terms; prohibiting pharmacies from selling certain drugs that can 17 be used in production of methamphetamine without a prescription; creating criminal offense 18 for possession of certain substances without a prescription with intent to transfer to another 19 to make methamphetamine; removing outdated language; providing criminal penalties; and 20 providing rule-making authority. 21 Be it enacted by the Legislature of West Virginia: 1 2015R3015 1 That §60A-2-210 and §60A-2-212 of the Code of West Virginia, 1931, as amended, be 2 amended and reenacted; and that §60A-10-2, §60A-10-4 and §60A-10-7 of said code be amended 3 and reenacted, all to read as follows: 4 ARTICLE 2. STANDARDS AND SCHEDULES. 5 §60A-2-210. Schedule IV.
    [Show full text]
  • Drug Enforcement Administration, Justice § 1308.13
    Drug Enforcement Administration, Justice § 1308.13 (2) Methamphetamine, its salts, (ii) 1- isomers, and salts of its iso- piperidinocyclohexanecarboni- mers ........................................ 1105 trile (PCC) ............................... 8603 (3) Phenmetrazine and its salts 1631 (3) Immediate precursor to fentanyl: (4) Methylphenidate ................... 1724 (5) Lisdexamfetamine, its salts, (i) 4-anilino-N-phenethyl-4-pi- isomers, and salts of its iso- peridine (ANPP) ...................... 8333 mers ........................................ 1205. (ii) [Reserved] (e) Depressants. Unless specifically [39 FR 22142, June 20, 1974] excepted or unless listed in another EDITORIAL NOTE: For FEDERAL REGISTER ci- schedule, any material, compound, tations affecting § 1308.12, see the List of CFR mixture, or preparation which contains Sections Affected, which appears in the any quantity of the following sub- Finding Aids section of the printed volume stances having a depressant effect on and at www.fdsys.gov. the central nervous system, including its salts, isomers, and salts of isomers § 1308.13 Schedule III. whenever the existence of such salts, (a) Schedule III shall consist of the isomers, and salts of isomers is possible drugs and other substances, by what- within the specific chemical designa- ever official name, common or usual tion: name, chemical name, or brand name (1) Amobarbital .......................... 2125 designated, listed in this section. Each (2) Glutethimide ......................... 2550 drug or substance has been
    [Show full text]
  • Laws 2021, LB236, § 4
    LB236 LB236 2021 2021 LEGISLATIVE BILL 236 Approved by the Governor May 26, 2021 Introduced by Brewer, 43; Clements, 2; Erdman, 47; Slama, 1; Lindstrom, 18; Murman, 38; Halloran, 33; Hansen, B., 16; McDonnell, 5; Briese, 41; Lowe, 37; Groene, 42; Sanders, 45; Bostelman, 23; Albrecht, 17; Dorn, 30; Linehan, 39; Friesen, 34; Aguilar, 35; Gragert, 40; Kolterman, 24; Williams, 36; Brandt, 32. A BILL FOR AN ACT relating to law; to amend sections 28-1202 and 69-2436, Reissue Revised Statutes of Nebraska, and sections 28-401 and 28-405, Revised Statutes Cumulative Supplement, 2020; to redefine terms, change drug schedules, and adopt federal drug provisions under the Uniform Controlled Substances Act; to provide an exception to the offense of carrying a concealed weapon as prescribed; to define a term; to change provisions relating to renewal of a permit to carry a concealed handgun; to provide a duty for the Nebraska State Patrol; to eliminate an obsolete provision; to harmonize provisions; and to repeal the original sections. Be it enacted by the people of the State of Nebraska, Section 1. Section 28-401, Revised Statutes Cumulative Supplement, 2020, is amended to read: 28-401 As used in the Uniform Controlled Substances Act, unless the context otherwise requires: (1) Administer means to directly apply a controlled substance by injection, inhalation, ingestion, or any other means to the body of a patient or research subject; (2) Agent means an authorized person who acts on behalf of or at the direction of another person but does not include a common or contract carrier, public warehouse keeper, or employee of a carrier or warehouse keeper; (3) Administration means the Drug Enforcement Administration of the United States Department of Justice; (4) Controlled substance means a drug, biological, substance, or immediate precursor in Schedules I through V of section 28-405.
    [Show full text]
  • 21 CFR Ch. II (4–1–13 Edition) § 1308.14
    § 1308.14 21 CFR Ch. II (4–1–13 Edition) (2) Any material, compound, mixture, or preparation stances, including its salts, isomers, containing any of the following narcotic drugs or and salts of isomers whenever the ex- their salts, as set forth below: (i) Buprenorphine ............................................. 9064 istence of such salts, isomers, and salts (ii) [Reserved]. of isomers is possible within the spe- (f) Anabolic Steroids. Unless specifi- cific chemical designation: cally excepted or unless listed in an- (1) Alprazolam ........................................................... 2882 (2) Barbital ................................................................. 2145 other schedule, any material, com- (3) Bromazepam ........................................................ 2748 pound, mixture or preparation con- (4) Camazepam ......................................................... 2749 taining any quantity of the following (5) Carisoprodol ....................................................... 8192 (6) Chloral betaine ..................................................... 2460 substances, including its salts, esters (7) Chloral hydrate .................................................... 2465 and ethers: (8) Chlordiazepoxide ................................................. 2744 (1) Anabolic steroids (see § 1300.01 of (9) Clobazam ............................................................. 2751 (10) Clonazepam ....................................................... 2737 this chapter)—4000 (11) Clorazepate ........................................................
    [Show full text]
  • Absorption of Drugs, 14-15 Elderly And, 320-321 Abstinence Syndrome In
    Index Abnormal Involuntary Movement Scale, 146- Akathisia (cont.) 149 symptom, 140 Absorption of drugs, 14-15 treatment of, 140-141 elderly and, 320-321 Akinesia, elderly, 328; see also Parkinson's Abstinence syndrome syndrome in alcohol abuse, 272-274 Akineton®: see Biperiden in cocaine abuse, 281 Alanon, 278, 279 major, 274 Alateen, 278, 279 minor, 272-273 Alcohol in psychoactive substance use disorders , 244 dependence, 269 self-treatment, 273 pharmacology, 268-269 Acetylcholine, 334 tolerance, 269 Acquired immune deficiency syndrome: see Alcohol abuse, 267-279 AIDS abstinence syndrome, 272-274 Acute dystonie reactions, 138-139 acute intoxieation, 270-271 antipsychotic drugs and, 138-139 alcoholic hallucinosis, 272-273, 275 diagnosis of, 138 alcohol idiosyncratic intoxication, 270-271 mechanism in, 139 behavioral treatment, 277-278 symptoms, 138 chronie intoxication, 271-272 treatment of, 139 definition of, 268 Adalat®: see Nifedipine delirium tremens, 274 Addiction: see Psychoactive substance use disor­ disease related to, 272 ders; Substance abuse disulfirarn treatment, 275-277 Adolescents fetal alcohol syndrome, 272 affective disorders, 373-374 halfway houses, 279 sleep disorders, 379, 380 insomnia and, 224 Adult Children of Alcoholics, 279 nervous system effects, 271 Aerosols: see Inhalants panic disorder and, 187 Affective disorders, children, 360, 373-374; see patterns of drinking in, 268 also Bipolar affective disorder; Depression postwithdrawal syndrome, 273 Aggression, children, 356, 361, 362 psychotherapy, 278 Agoraphobia,
    [Show full text]
  • Drugs and Medical Devices Group
    TEXAS DEPARTMENT OF HEALTH AUSTIN, TEXAS INTER-OFFICE MEMORANDUM TO: Charles E. Bell, M.D. Executive Deputy Commissioner THRU: Susan K. Steeg, General Counsel Office of General Counsel THRU: Debra C. Stabeno, M.P.H. Deputy Commissioner for Programs FROM: Richard B. Bays Associate Commissioner for Consumer Health Protection DATE: October 11, 2001 SUBJECT: Order Amending Controlled Substance Schedules • Pursuant to Section 481.034(g), as amended by the 75th legislature, of the Texas Controlled Substances, Act Chapter 481, Health and Safety Code, your signature as Executive Deputy Commissioner and the seal of the Department are required on the attached order. Please note date of signing to be entered in the last paragraph of the order. • If you concur, please return the original document bearing your signature and seal to the Drugs and Medical Devices Division where it will be retained as an official record. Attachments The Acting Administrator of the Drug Enforcement Administration (DEA) has issued a final rule listing the substance dichloralphenazone, including its salts, isomers, and salts of isomers in Schedule IV of the Federal Controlled Substances Act (CSA). Dichloralphenazone is a sedative typically used in combination with isometheptene mucate and acetaminophen in formulating prescription pharmaceuticals for the relief of tension and vascular headache. Since dichloralphenazone is a compound containing chloral hydrate, it is likewise a Schedule IV depressant. This action was based on the following: (1) dichloralphenazone is a compound containing two molecules of chloral hydrate and one molecule of phenazone; (2) chloral hydrate is a Schedule IV depressant; and, (3) since dichloralphenazone has not been recognized as a compound containing chloral hydrate and confusion has existed with regard to its control status, the DEA issued a proposed rule in the Federal Register on December 11, 2000 to expressly list dichloralphenazone as a Schedule IV depressant.
    [Show full text]
  • Drug/Substance Trade Name(S)
    A B C D E F G H I J K 1 Drug/Substance Trade Name(s) Drug Class Existing Penalty Class Special Notation T1:Doping/Endangerment Level T2: Mismanagement Level Comments Methylenedioxypyrovalerone is a stimulant of the cathinone class which acts as a 3,4-methylenedioxypyprovaleroneMDPV, “bath salts” norepinephrine-dopamine reuptake inhibitor. It was first developed in the 1960s by a team at 1 A Yes A A 2 Boehringer Ingelheim. No 3 Alfentanil Alfenta Narcotic used to control pain and keep patients asleep during surgery. 1 A Yes A No A Aminoxafen, Aminorex is a weight loss stimulant drug. It was withdrawn from the market after it was found Aminorex Aminoxaphen, Apiquel, to cause pulmonary hypertension. 1 A Yes A A 4 McN-742, Menocil No Amphetamine is a potent central nervous system stimulant that is used in the treatment of Amphetamine Speed, Upper 1 A Yes A A 5 attention deficit hyperactivity disorder, narcolepsy, and obesity. No Anileridine is a synthetic analgesic drug and is a member of the piperidine class of analgesic Anileridine Leritine 1 A Yes A A 6 agents developed by Merck & Co. in the 1950s. No Dopamine promoter used to treat loss of muscle movement control caused by Parkinson's Apomorphine Apokyn, Ixense 1 A Yes A A 7 disease. No Recreational drug with euphoriant and stimulant properties. The effects produced by BZP are comparable to those produced by amphetamine. It is often claimed that BZP was originally Benzylpiperazine BZP 1 A Yes A A synthesized as a potential antihelminthic (anti-parasitic) agent for use in farm animals.
    [Show full text]
  • October 1, 1998
    TED SAKAI NEIL ABERCROMBIE DIRECTOR GOVERNOR Martha Torney Deputy Director Administration Max Otani Deputy Director Corrections Shawn Tsuha STATE OF HAWAII Deputy Director NARCOTICS ENFORCEMENT Law Enforcement DIVISION Department of Public Safety No. Posted at LT Gov office 3375 Koapaka Street, Suite D-100 9-8-14 Honolulu, Hawaii 96819 September 8, 2014 NOTICE OF FEDERAL SCHEDULING ACTIONS Section 329-11(d) states that if a substance is added, deleted or rescheduled under federal law and notice of the designation is given to the department then the department shall recommend to the legislature that a corresponding change in Hawaii law be made. The Department was given notice that the following depressant drug was placed into Schedule IV by the Federal Government: [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3- triazol-2-yl)phenyl]methanone (suvorexant), including its salts, isomers, and salts of isomers. On August 28, 2014, the Department was given notice that [(7R)-4-(5-chloro-1,3-benzoxazol-2- yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (suvorexant), including its salts, isomers, and salts of isomers, into schedule IV of the Controlled Substances Act (CSA). This scheduling action is pursuant to the CSA which requires that such actions be made on the record after opportunity for a hearing through formal rulemaking. This action imposes the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule IV controlled substances on persons who handle (manufacture, distribute, dispense, import, export, engage in research, conduct instructional activities with, or possess) or propose to handle suvorexant.
    [Show full text]