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Chapter Four – TRPA1 Channels: Chemical and Temperature Sensitivity
CHAPTER FOUR TRPA1 Channels: Chemical and Temperature Sensitivity Willem J. Laursen1,2, Sviatoslav N. Bagriantsev1,* and Elena O. Gracheva1,2,* 1Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA 2Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA *Corresponding author: E-mail: [email protected], [email protected] Contents 1. Introduction 90 2. Activation and Regulation of TRPA1 by Chemical Compounds 91 2.1 Chemical activation of TRPA1 by covalent modification 91 2.2 Noncovalent activation of TRPA1 97 2.3 Receptor-operated activation of TRPA1 99 3. Temperature Sensitivity of TRPA1 101 3.1 TRPA1 in mammals 101 3.2 TRPA1 in insects and worms 103 3.3 TRPA1 in fish, birds, reptiles, and amphibians 103 3.4 TRPA1: Molecular mechanism of temperature sensitivity 104 Acknowledgments 107 References 107 Abstract Transient receptor potential ankyrin 1 (TRPA1) is a polymodal excitatory ion channel found in sensory neurons of different organisms, ranging from worms to humans. Since its discovery as an uncharacterized transmembrane protein in human fibroblasts, TRPA1 has become one of the most intensively studied ion channels. Its function has been linked to regulation of heat and cold perception, mechanosensitivity, hearing, inflam- mation, pain, circadian rhythms, chemoreception, and other processes. Some of these proposed functions remain controversial, while others have gathered considerable experimental support. A truly polymodal ion channel, TRPA1 is activated by various stimuli, including electrophilic chemicals, oxygen, temperature, and mechanical force, yet the molecular mechanism of TRPA1 gating remains obscure. In this review, we discuss recent advances in the understanding of TRPA1 physiology, pharmacology, and molecular function. -
'Ofe Akwu' Soup Spoilage
Microbiology Research Journal International 19(3): 1-8, 2017; Article no.MRJI.32554 Previously known as British Microbiology Research Journal ISSN: 2231-0886, NLM ID: 101608140 SCIENCEDOMAIN international www.sciencedomain.org Inhibitory Potential of Ocimum gratissimum L on Bacterial Implicated in ‘Ofe Akwu’ Soup Spoilage O. C. Eruteya 1* , F. S. Ire 1 and C. C. Aneke 1 1Department of Microbiology, University of Port Harcourt, Port Harcourt, Nigeria. Authors’ contributions This work was carried out in collaboration between all authors. Authors OCE and FSI designed the study. All authors participated in the laboratory analysis. Author OCE wrote the first draft of the manuscript. All authors read and approved the final manuscript. Article Information DOI: 10.9734/MRJI/2017/32554 Editor(s): (1) Ana Cláudia Coelho, Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Portugal. Reviewers: (1) Vishwanadham Yerragunta, JNTU-Hydrabad, India. (2) P. Rameshthangam, Alagappa University, Karaikudi, Tamilnadu, India. (3) Julius Tibyangye, St. Augustine International University/Kampala International University, Uganda. Complete Peer review History: http://www.sciencedomain.org/review-history/18590 Received 1st March 2017 Accepted 29 th March 2017 Original Research Article th Published 11 April 2017 ABSTRACT Aims: The study evaluated the proximate composition, the bacteria present in freshly spoilt ‘ofe akwu’ soup and inhibitory potential of crude ethanol, methanol and aqueous leaf extract of Ocimum gratissimum on the resulting bacteria. Study Design: This was an analytical study in duplicate. Place and Duration of Study: Department of Microbiology, University of Port Harcourt, Niger Delta University, Amasoma, and South Africa, between July 2015 and December 2016. -
Edible Academy Fresh from the Garden Tastings
EDIBLE ACADEMY FRESH FROM THE GARDEN TASTINGS RADISH SALAD Inspired by The Forest Feast Cookbook by Erin Gleeson Yield: 2 servings Ingredients 3 large radishes, thinly sliced (use watermelon radishes when available) 2 oranges, peeled and cut into bite-sized pieces ½ red onion, peeled and sliced into thin rings 2 sprigs mint 2 scallions, chopped ½ tablespoon 365 Everyday Value® Extra Virgin Olive Oil 365 Everyday Value® Coarse Sea Salt, to taste 365 Everyday Value® products are found exclusively at Whole Foods Market®. Instructions Using a mandolin, thinly slice the radishes and onion. In a large bowl, mix the radishes, onion, and oranges. Remove the mint leaves from the stem and cut into ribbons. Add the mint and scallions to the large bowl. Drizzle the olive oil and add sea salt to taste. Serve chilled. Sponsors In affiliation with nybg.org EDIBLE ACADEMY FRESH FROM THE GARDEN TASTINGS ALLIUM-HERB CONFETTI Shared by the Edible Academy’s Children’s Gardening Program Serves many for light bites or 4 very hungry people Ingredients 1 baguette, cut into slices and toasted 1 cup of fresh herbs and alliums, chopped (any or all of the following: basil, sage, mint, rosemary, thyme, oregano, cilantro, chives, scallions, garlic, or onions) ¼ cup of crème fraiche or 365 Everyday Value® Whipped Cream Cheese 365 Everyday Value® products are found exclusively at Whole Foods Market®. Instructions Finely chop all herbs; mince all alliums. Toss gently. On baguette slices, spread crème fraiche or cream cheese. Dress with a sprinkle of allium-herb confetti, -
Show Activity
A Cytochrome-P450-Inhibitor *Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press. Plant # Chemicals Total PPM Acacia farnesiana Huisache; Cassie; Popinac; Sweet Acacia; Opopanax 2 Achillea millefolium Yarrow; Milfoil 1 Acorus calamus Flagroot; Sweetroot; Sweet Calamus; Myrtle Flag; Calamus; Sweetflag 1 384.0 Agastache rugosa 1 Ageratum conyzoides Mexican ageratum 1 Aloysia citrodora Lemon Verbena 1 Alpinia officinarum Lesser Galangal; Chinese Ginger 1 800.0 Alpinia galanga Siamese Ginger; Languas; Greater Galangal 1 24000.0 Ammi majus Bishop's Weed 2 16000.0 Anacardium occidentale Cashew 1 Anethum graveolens Garden Dill; Dill 1 Angelica dahurica Bai Zhi 2 Angelica archangelica Angelica; Wild Parsnip; Garden Angelica 2 5050.0 Apium graveolens Celery 3 Artemisia dracunculus Tarragon 2 141.0 Boronia megastigma Scented Boronia 1 Calamintha nepeta Turkish Calamint 1 Camellia sinensis Tea 2 Cananga odorata Cananga; Ylang-Ylang 1 Capsicum frutescens Tabasco; Cayenne; Chili; Hot Pepper; Spur Pepper; Red Chili 1 35800.0 Capsicum annuum Cherry Pepper; Cone Pepper; Paprika; Bell Pepper; Sweet Pepper; Green Pepper 2 8000.0 Centaurea calcitrapa Star-Thistle 1 Chenopodium album Lambsquarter 1 Cinnamomum verum Ceylon Cinnamon; Cinnamon 1 20320.0 Cinnamomum camphora Camphor; Ho Leaf 1 Cinnamomum aromaticum Cassia Lignea; Chinese Cassia; Chinesischer Zimtbaum (Ger.); Canela de la China (Sp.); 1 Saigon Cinnamon; Chinazimt (Ger.); Kashia-Keihi -
Companion Plants for Better Yields
Companion Plants for Better Yields PLANT COMPATIBLE INCOMPATIBLE Angelica Dill Anise Coriander Carrot Black Walnut Tree, Apple Hawthorn Basil, Carrot, Parsley, Asparagus Tomato Azalea Black Walnut Tree Barberry Rye Barley Lettuce Beans, Broccoli, Brussels Sprouts, Cabbage, Basil Cauliflower, Collard, Kale, Rue Marigold, Pepper, Tomato Borage, Broccoli, Cabbage, Carrot, Celery, Chinese Cabbage, Corn, Collard, Cucumber, Eggplant, Irish Potato, Beet, Chive, Garlic, Onion, Beans, Bush Larkspur, Lettuce, Pepper Marigold, Mint, Pea, Radish, Rosemary, Savory, Strawberry, Sunflower, Tansy Basil, Borage, Broccoli, Carrot, Chinese Cabbage, Corn, Collard, Cucumber, Eggplant, Beet, Garlic, Onion, Beans, Pole Lettuce, Marigold, Mint, Kohlrabi Pea, Radish, Rosemary, Savory, Strawberry, Sunflower, Tansy Bush Beans, Cabbage, Beets Delphinium, Onion, Pole Beans Larkspur, Lettuce, Sage PLANT COMPATIBLE INCOMPATIBLE Beans, Squash, Borage Strawberry, Tomato Blackberry Tansy Basil, Beans, Cucumber, Dill, Garlic, Hyssop, Lettuce, Marigold, Mint, Broccoli Nasturtium, Onion, Grapes, Lettuce, Rue Potato, Radish, Rosemary, Sage, Thyme, Tomato Basil, Beans, Dill, Garlic, Hyssop, Lettuce, Mint, Brussels Sprouts Grapes, Rue Onion, Rosemary, Sage, Thyme Basil, Beets, Bush Beans, Chamomile, Celery, Chard, Dill, Garlic, Grapes, Hyssop, Larkspur, Lettuce, Cabbage Grapes, Rue Marigold, Mint, Nasturtium, Onion, Rosemary, Rue, Sage, Southernwood, Spinach, Thyme, Tomato Plant throughout garden Caraway Carrot, Dill to loosen soil Beans, Chive, Delphinium, Pea, Larkspur, Lettuce, -
Changes and Substitutions to Home Food Processing Recipes the Safety of the Food That You Preserve for Your Family and Friends Is Important to You
Play it Safe: Changes and Substitutions to Home Food Processing Recipes The safety of the food that you preserve for your family and friends is important to you. The University of Wisconsin-Extension supports using up-to-date, research-tested recipes so that you know that the food that you preserve is both safe and high in quality. Here are a few quick tips on changes and substitutions that will keep your home preserved food safe to eat. Canning Fruits Sugar is added to canned fruits help preserve color, help firm texture, and for flavor. Choose a light fruit juice such as white grape juice for canning if you wish to reduce sugar in home- canned fruit. You may safely eliminate sugar altogether when canning fruits at home, if you prefer. However, fruit canned in water is generally considered unappealing, and will spoil more quickly once opened. There are no tested recipes for using sugar substitutes such as Sucralose in home canning. Refer to the manufacturer for directions for home canning using a sugar substitute. Canning Meat Meat is low in acid and must be canned in a pressure canner. You may add a small amount of seasoning, onions, or garlic when home-canning meat without changing the processing time. Canned meat products must never be thickened with flour or cornstarch; rice, pasta or barley must never be added; and fat must not be added – any of these changes can result in an unsafe product. Only add meat when called for in a tested recipe. For example, don’t add meat to spaghetti sauce unless the recipe allows this addition. -
Seasonal Incidence of Ocimum Tingid Bug, Cochlochila Bullita Stal
Journal of Pharmacognosy and Phytochemistry 2020; 9(4): 3138-3144 E-ISSN: 2278-4136 P-ISSN: 2349-8234 www.phytojournal.com Seasonal incidence of Ocimum tingid bug, JPP 2020; 9(4): 3138-3144 Received: 07-05-2020 Cochlochila bullita Stal (Heteroptera: Tingidae) Accepted: 09-06-2020 on three different species of Ocimum viz. Ocimum Vishav Prakash Rahul basilicum L., Ocimum sanctum L. and Ocimum CSIR-Indian Institute of Integrative Medicine, Canal kilimandscharicum Guerke Road, Jammu, Jammu and Kashmir, India Vishav Prakash Rahul, Bhumika Kapoor, Sougata Sarkar and Sabha Jeet Bhumika Kapoor Project Assistant, CSIR-Indian Institute of Integrative DOI: https://doi.org/10.22271/phyto.2020.v9.i4ae.12093 Medicine, Canal Road, Jammu, Jammu and Kashmir, India Abstract The field experiment was conducted on the seasonal incidence Ocimum lace bug on three different Sougata Sarkar species of Ocimum viz. Ocimum basilicum L., Ocimum sanctum L. and Ocimum kilimandscharicum Research Associate, Scientist, Guerke at CSIR- IIIM, Chatha Farm, Jammu. The data on seasonal fluctuations of Ocimum tingid bug, CSIR-Indian Institute of Cochlochila bullita on various species of Ocimum such as Ocimum basilicum L., Ocimum sanctum L. Integrative Medicine, Canal and Ocimum kilimandscharicum Guerke were first observed during 33rd standard week of August i.e. Road, Jammu, Jammu and 0.40 Mean insect/ plant, 0.2 mean insect/plant and 0.20 mean insect/plant, respectively. The maximum Kashmir, India lace bug population was recorded on sweet basil during 39th standard week i.e. 52.60 mean insect/ plant when weekly mean maximum temperature 29.7 oC, minimum temperature 23.1 oC, morning relative Sabha Jeet Scientist, CSIR-Indian Institute humidity 93.1% and evening relative humidity 75.90 %, rainfall 93.40 mm, and wind speed 2.00 km/hr, of Integrative Medicine, Canal respectively. -
CHICKPEA CROSTINI Pear, Grilled Mustard Greens, Gorgonzola 10
items to be shared by the table SEAFOOD FRITTO MISTO 14 PORK MEATBALLS 12 ARANCINI 11 arugula, lemon tomato, fig mostarda smoked caciocavallo, sicilian pesto CURED SALUMI PLATTER 16 CHEESE PLATTER 15 LA QUERCIA PROSCIUTTO 12 pickles, mustard mostarda, condimenti white wine braised fennel, capers, grapes CHICKPEA CROSTINI pear, grilled mustard greens, gorgonzola 10 FARM EGG** polenta, foraged mushroom 10 SMOKED ARCTIC CHAR apricot mostarda, hazelnut, gaeta olive 12 WARM MOZZARELLA pistachio mascarpone, italian herbs, apple 12 GIARDINARA SALAD farm greens, potato, smoked almond, chili, pickled corn, fried onion 12 RYE LUMACHE brown butter, roasted sunchoke, texas golden beet, smoked caciocavallo 18 RICOTTA RAVIOLI butternut squash, sumac biscotti, preserved cherry, cured egg yolk 17 BUCATINI AMATRICIANA pomodoro, calabrese chili, guanciale, pecorino 17 TRIANGOLI texas lamb, fennel, orange, eggplant, mint, castelvetrano olive, pecorino romano 18 LINGUINE NERO rock shrimp, calamari, red onion, arugula, breadcrumbs 19 RISOTTO brown butter butternut squash, celery, endive, lemon, parmigiano reggiano 18 TEXAS NEW YORK STRIP panzanella, tomato vinaigrette, frisée, blistered tomato, parsley 36 TEXAS GULF BLACK DRUM baby lettuce, spaghetti squash, shallot, pistachio, acciuga crema 28 GRILLED TEXAS LAMB LEG sweet pepper, onion, rosemary, garlic confit, lamb jus, mustard 27 MARINATED SUMMER SQUASH ricotta salata, pickled red onion, pine nuts, garlic, oregano 8 NEW POTATOES gaeta olives, grape tomatoes, breadcrumbs, pancetta vinaigrette 8 CRISPY EGGPLANT garlic, celery, olives, capers, raisins, white wine 10 **There is a risk associated with consuming raw animal protein. If you have a chronic illness of the liver, stomach or blood or have immune disorder, you are at greatest risk of illness from meat. -
Auxins for Hardwood Cuttings: Effect of Root-Promoting Hormones
Auxins for Hardwood Cuttings effect of root-promoting hormones in propagating fruit trees by hardwood cuttings studied during past three seasons H. T. Hartmann Hardwood cuttings of five species of fruit trees, Marianna 2624 plum, Angers quince, Stockton Morello cherry, Mal- ling-Merton 793 apple, and Mission olive, were used in propagation tests to study the effects of various root-promot- ing hormones-auxins-applied under several different conditions. Marianna 2624 plum is a commonly used rootstock for a number of the stone fruit species; the 2624 selection is a seedling of the parent Marianna plum, presumably an open-pollinated cross of Prunus cerasifera and P. munsoniana. This rootstock is propagated commer- cially by hardwood cuttings, but in heavy soils considerable difficulty is often experienced in obtaining satisfac- tory rooting. Angers quince4ydonia oblong- has long been used as a dwarfing root- stock for certain of the pear varieties. It is commercially propagated by hard- wood cuttings. Stockton Morello cherry-Prunus cer- asus-is used to a considerable extent in California as a semidwarfing rootstock for the sweet cherry and is propagated commercially by suckers arising around the base of older trees. It would be de- sirable to be able to propagate this stock by cuttings. In all the tests conducted with this variety, however, not one hard- wood cutting was induced to root. Later studies have shown that it can be easily rooted under mist humidification by softwood cuttings taken from actively growing shoots if treated with indolebu- tyric acid. The Malling-Merton 793 apple-Ma- lus sylwstris-is a newly developed clonal apple rootstock from’ England which is usually propagated by some method of layering. -
Angelica Arugula 'Wasabi' Basil, African Blue Basil, Amazel Basil
Variety Description Culinary Uses Works Well With Type Angelica The foliage has a slight celery taste which can be used Jams and Jellies, Salads, Lavender, Lemon Perennial in recipes. The young flowering stalks, which has a Stewed Fruits, Tea Balm, Nutmeg, mildly sweet flavor, can be peeled and cooked or Pepper candied. Artichoke 'Imperial Star' These plants have grey-green foliage that grows up to Side vegetable, stuffing, If left unharvested it Annual 4' in height and width. You will get an abundance of 4 soups, stew, steamed, will produce lg. 1/2" artichoke that has a sweet and mild flavor. roasted, braised or grilled. purple, thistle-like blooms that are great for arrangements. Arugula 'Wasabi' This arugula has a sharp, tangy bite with a spicy, nutty Great for cooking, eating Annual flavor. Deep green spoon shaped leaves can be sowed fresh or in salads multiple times during the summer. Basil, African Blue Basil is an exquisite culinary herb that also makes an Sour Cream for Baked Parsley, Chives, Dill, Annual attractive addition to the garden. Great seasoning for Potatoes, Pasta Dishes, Garlic, Onion pastas, pizzas and sauces. The flowers are pink with a Ginger Ale dark purple calyx, making them attractive, and tasty, for salads, drinks or garnishes. Basil, Amazel Basil is an exquisite culinary herb that also makes an Tomato Dishes, Pasta Sauces, Garlic, Marjoram, Annual attractive addition to the garden. This Italian Sweet Salads, Poultry, Herb Vinegars Oregano, Parsley, Basil is unlike other basils it is seed sterile. That means Rosemary you get more and longer yields of usable aromatic leaves. -
Honey Bee Suite © Rusty Burlew 2015 Master Plant List by Scientific Name United States
Honey Bee Suite Master Plant List by Scientific Name United States © Rusty Burlew 2015 Scientific name Common Name Type of plant Zone Full Link for more information Abelia grandiflora Glossy abelia Shrub 6-9 http://plants.ces.ncsu.edu/plants/all/abelia-x-grandiflora/ Acacia Acacia Thorntree Tree 3-8 http://www.2020site.org/trees/acacia.html Acer circinatum Vine maple Tree 7-8 http://www.nwplants.com/business/catalog/ace_cir.html Acer macrophyllum Bigleaf maple Tree 5-9 http://treesandshrubs.about.com/od/commontrees/p/Big-Leaf-Maple-Acer-macrophyllum.htm Acer negundo L. Box elder Tree 2-10 http://www.missouribotanicalgarden.org/PlantFinder/PlantFinderDetails.aspx?kempercode=a841 Acer rubrum Red maple Tree 3-9 http://www.missouribotanicalgarden.org/PlantFinder/PlantFinderDetails.aspx?taxonid=275374&isprofile=1&basic=Acer%20rubrum Acer rubrum Swamp maple Tree 3-9 http://www.missouribotanicalgarden.org/PlantFinder/PlantFinderDetails.aspx?taxonid=275374&isprofile=1&basic=Acer%20rubrum Acer saccharinum Silver maple Tree 3-9 http://en.wikipedia.org/wiki/Acer_saccharinum Acer spp. Maple Tree 3-8 http://en.wikipedia.org/wiki/Maple Achillea millefolium Yarrow Perennial 3-9 http://www.missouribotanicalgarden.org/PlantFinder/PlantFinderDetails.aspx?kempercode=b282 Aesclepias tuberosa Butterfly weed Perennial 3-9 http://www.missouribotanicalgarden.org/PlantFinder/PlantFinderDetails.aspx?kempercode=b490 Aesculus glabra Buckeye Tree 3-7 http://www.missouribotanicalgarden.org/PlantFinder/PlantFinderDetails.aspx?taxonid=281045&isprofile=1&basic=buckeye -
NOON Located Just Off Henry Thomas Drive Sout
NEW ORLEANS BOTANICAL GARDEN PLANT SALE PELICAN GREENHOUSE AUGUST 6, 2016 9 AM – NOON Located just off Henry Thomas Drive south of the 1-610 underpass Lucky Lantern Yellow Abutilon Abutilon ‘Lucky Lantern’ 01 Flowering Maple Abutilon pictum 01 Abutilon Variegated Abutilon pictum ‘Gold Dust’ 01 Nabob Abutilon Abutilon x hybridum ‘Nabob’ 01 Amaryllis Amaryllis hippeastrum 01 Butterfly Iris Dietes iridioides 01 St John’s Wort Hypericum perforatum 01 Shasta Daisy Leucanthemum superbum 01 Red Firecracker Russelia sarmentosa 01 Hanging Baskets Scaevola 01 Red Fountain Scutellaria Scutellaria longifolia 01 Bridal Wreath Spirea cantoniensis 01 Variegated Jewels of Opar Talinum paniculatum ‘Variegatum’ 01 Eastern Blue Star Amsonia tabernaemontana 02 Swamp Milkweed Asclepias incarnata 02 Swamp milkweed Asclepias incarnata ‘Soulmate’ 02 Common Milkweed Asclepias syriaca 02 Milkweed Asclepias tuberosa 02 White Wild Indigo Baptisia alba 02 Buttonbush Cephalanthus occidentalis 02 Blue Mist Flower Conoclinium coelestinum 02 Lanceleaf Coreopsis Coreopsis lanceolata 02 Clasping Coneflower Dracopis(Rudbeckia) amplexicaulis 02 Purple Coneflower Echinacea purpurea 02 Maximilian Sunflower Helianthus maximiliani 02 Ashy Sunflower Helianthus mollis 02 Virginia Willow Itea virginica 02 Orange Shrimp Plant Justicia fulvicoma 02 Blazing Star Liatris spicata ‘Kobold’ 02 Cardinal Flower Lobelia cardinalis 02 Coral Honeysuckle Lonicera sempervirens 02 Dwarf Barbados Cherry Malpighia glabra ‘Nana’ 02 Turk’s Cap Malvaviscus arboreus var. Drummondii 02 Foxglove Penstemon