PERSPECTIVE ARTICLE published: 22 March 2013 doi: 10.3389/fphys.2013.00053 Robert K. Crane—Na+-glucose cotransporter to cure? Kirk L. Hamilton* Department of Physiology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand Edited by: Dr. Robert K. Crane made major contributions to our understanding of carbohydrate Christine Kranz, University of Ulm, metabolism and transport of the intestine over a very long and productive career. This Germany Perspective examines, briefly, his early life and academic positions, but more importantly, Reviewed by: this Perspective highlights his contributions to the understanding of coupled Na+-glucose Paul Dietl, University of Ulm, Germany absorption by the small intestine. I discuss how his early hypothesis of a “cotransport” of Olivier Devuyst, University of Zurich, sodium and glucose ushered in and provided the physiological explanation for the clinical Switzerland treatment of acute diarrhea and cholera when using oral rehydration therapy (ORT). ORT *Correspondence: saves millions of lives each year. Certainly, humankind is better off because of Crane’s Kirk L. Hamilton, Department of hypothesis of the Na+-glucose cotransporter that he put forth over 50 years ago? Physiology, Otago School of Medical Sciences, University of Otago, Keywords: sodium-glucose cotransporter, SGLT1, diarrhea, cholera, oral rehydration therapy 270 Great King Street, PO Box 913, Dunedin, New Zealand. e-mail:
[email protected] OVERVIEW Department of Biological Chemistry at Washington University I wish to start this Perspective with a few key questions. First, School of Medicine in St. Louis. For the next 12 years whilst at how does one measure the impact of a hypothesis on humankind? Washington University, Crane continued his research in carbohy- Secondly, how can one measure the impact of a simple idea which drate metabolism (Crane, 2010).