Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_001413955Cyc: Flagellimonas eckloniae DOKDO 007 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

RseP RS02080 RS12680 RS05205 RS02890 RS16380 RS09470 YidC RS08990 TrkA LptB RS00355 FtsA RS15830 SecA RS13950 RS03435 RS05860 RS12230 RS09345 RS01565 TatC YajC RS14455 RS15710 RS04460

RS06290 RS01700 Aromatic Compound Fermentation tRNA charging Aminoacyl-tRNA Charging Biosynthesis a nascent a [bis(guanylyl (4R)-4-hydroxy- 5-dehydro- superpathway of β-D- Carboxylate Degradation 34 H O an N-modified an L-asparaginyl- an L-cysteinyl- a 5,10-gly a uridine diphosphate 2 peptidoglycan molybdopterin) 4-deoxy-D- (S)-lactate fermentation to propanoate, acetate and hydrogen propanoyl CoA superpathway of acetate cys 2-oxoglutarate Asn Cys ATP roseoflavin chorismate biosynthesis I glucuronosides degradation aminoacyl-[tRNA] [tRNA ] [tRNA ] phe a tRNA Phe degradation I utilization and formation methylenetetrahydrofolate in tRNA (meso-DAP 5'-phosphate glucuronate 5-dehydro- RS07745 RS16695 containing) chaperone]- 4-deoxy-D- D-erythrose (S)-lactate a β-D-glucuronoside bifunctional propanoyl-CoA acetate tRNA uridine-5- inorganic L-cysteine aminoacyl-tRNA aminoacyl-tRNA aminoacyl-tRNA glucuronate 4-phosphate acetate--CoA 4-hydroxy-2- phenylalanine- bifunctional 3-deoxy-7- acyl-CoA diphosphatase: bifunctional gln a tRNA Gln : acs carboxymethylaminomethyl(34) lytic : hydrolase: hydrolase: : phosphoheptulonate AAY42_RS08320 oxoglutarate riboflavin kinase/ -tRNA ligase ser asp Ala carboxylase acetate kinase: synthesis GTPase MnmE: mnmE AAY42_RS10640 AAY42_RS10640 AAY42_RS10640 kduI ser a tRNA tRNA asp a tRNA ala transglycosylase cysteine aldolase/2- subunit beta: elongator synthase/chorismate subunit beta: AAY42_RS00930 sodium-translocating FAD synthetase: RS01960 his a tRNA His thr a tRNA Thr asn tRNA Asn met initiator tRNA Met met trp a tRNA Trp glu a tRNA glu ile a tRNA Ile gly a tRNA Gly leu a tRNA Leu tyr a tRNA Tyr lys a tRNA Lys arg a tRNA Arg cys a tRNA Cys pro a tRNA Pro tRNA uridine-5- domain-containing desulfurase: aminoacyl- dehydro-3-deoxy- aminoacyl- aminoacyl- 5-dehydro- AAY42_RS02665 tRNA Met mutase type II: D-glucopyranuronate AAY42_RS00780 pyrophosphatase: AAY42_RS10655 Val glutamine-- pyruvate carboxymethylaminomethyl(34) protein: AAY42_RS12000 tRNA tRNA tRNA val a tRNA AAY42_RS08180 phosphogluconate 4-deoxy-D- phenylalanine- serine- aspartate- tRNA ligase/ alanine- 3-deoxy- acyl-CoA acetyl phosphate acetyl-CoA AAY42_RS08315 AAY42_RS01870 synthesis MnmG: mnmG cysteine hydrolase: aldolase: hydrolase: hydrolase: glucuronate F0F1 ATP histidine-- -tRNA ligase threonine- asparagine- -tRNA - methionine- -tRNA tryptophan- glutamate-- YqeY domain isoleucine-- glycine-- leucine-- tyrosine-- -tRNA lysine- arginine-- cysteine-- proline-- D-arabino- carboxylase roseoflavin + + pyruvate carboxylase: endolytic desulfurase: arfB AAY42_RS07680 arfB arfB isomerase: H synthase H tRNA ligase: subunit -tRNA -tRNA ligase: -tRNA -tRNA ligase: -tRNA tRNA ligase: fusion protein: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: ligase: -tRNA tRNA ligase: tRNA ligase: tRNA ligase: heptulosonate subunit beta: adenine valine--tRNA ligase: 34 transglycosylase AAY42_RS00510 kduI AAY42_RS06400 a 5-carboxymethylaminomethyluridine H + dinucleotide 3-deoxy-D- AAY42_RS02240 alpha: pheS ligase: thrS AAY42_RS07240 ligase: asnS serS ligase: metG ligase: metG aspS ligase: trpS AAY42_RS12625 AAY42_RS12645 AAY42_RS13660 AAY42_RS13795 AAY42_RS14405 AAY42_RS14480 alaS ligase: lysS AAY42_RS16255 AAY42_RS16895 AAY42_RS16925 7-phosphate aldehydo-D-glucuronate AAY42_RS04625 phosphate a 7,8-dihydrofolate phosphate MltG: mltG (S)-methylmalonyl- in tRNA an uncharged glycero-2,5- 3-dehydroquinate acetyltransferase: pta an N-modified Asn Cys glucuronate CoA a [bis(guanylyl glyoxylate pyruvate asn tRNA cys a tRNA hexodiulosonate F0F1 ATP an L-methionyl- oxaloacetate formate acetyl-CoA amino acid tRNA + + an L-histidyl- an L-phenylalanyl- an L-threonyl- an L-valyl- an L-asparaginyl- an L-seryl- an L-methionyl- an L-aspartyl- an L-tryptophanyl- an L-glutamyl- an L-glutaminyl- an L-isoleucyl- an L-leucyl- an L-tyrosyl- an L-alanyl- an L-lysyl- an L-arginyl- an L-cysteinyl- an L-prolyl- synthase: molybdopterin) H H [elongator a glycyl-[tRNA Gly ] isomerase: methylmalonyl- a mature a nascent ala synthase [tRNA His ] [tRNA Phe ] [tRNA Thr ] [tRNA Val ] [tRNA Asn ] [tRNA ser ] [initiator tRNA Met ] [tRNA asp ] [tRNA Trp ] [tRNA Glu ] [tRNA Gln ] [tRNA Ile ] [tRNA Leu ] [tRNA Tyr ] [tRNA Ala ] [tRNA Lys ] [tRNA Arg ] [tRNA Cys ] [tRNA Pro ] AAY42_RS05600 Met malate phosphate uxaC CoA peptidoglycan peptidoglycan cofactor tRNA ] 3-dehydroquinate dehydrogenase: mdh acetyltransferase: pta epimerase: mce pyruvate decarboxylation to acetyl CoA I with (L-alanyl- (meso-DAP chaperone]-S- synthase: aroB D-fructuronate γ sulfanyl-L-cysteine a reduced (R)-methylmalonyl- pyruvate -D-glutamyl- containing) with (S)-malate H a [pyruvate dehydrogenase GlcNAc terminus H O c-type 3-dehydroquinate 2 acetyl phosphate CoA dehydrogenase meso-2,6- 2 E2 protein] N 6 -lipoyl-L-lysine diaminopimeloyl- RS09025 ancytochrome oxidized methylmalonyl- complex E1 type II 3- class II fumarate acetate kinase: pyruvate D-alanine) O c-type CoA mutase component 2 Nucleoside and Nucleotide Biosynthesis dehydroquinate hydratase: fumC AAY42_RS00930 D-mannonate tetrapeptide cytochromea reduced subunit beta: subunit beta: dehydratase: aroQ H O c-type AAY42_RS08330 2 cbb3-type fumarate acetate mannonate AAY42_RS00755 cytochrome superpathway of UDP-N-acetylmuramoyl- a peptidoglycan 6-O-trans- cytochrome an oxidized Fatty Acid and Lipid Biosynthesis superpathway of guanosine superpathway of 5-aminoimidazole ribonucleotide biosynthesis I pyrimidine deoxyribonucleotides superpathway of pyrimidine 3-dehydroshikimate dehydratase: methylmalonyl- dihydrolipoyl pyruvate 3-aci- a [protein]- phosphoenol L-rhamnulose a [protein]-L- pyrimidine ribonucleotides hydrogen selenide γ serotonin O c oxidase c-type nucleotides de novo biosynthesis I fumarate reductase/ uxuA O-acetyl-L-serine nitropropanoate L-alanyl- -D- dimer (generic) L-glutamine methoxy-mycolyl- 1-phosphate methionine 2 nucleotides de novo biosynthesis I nucleobases salvage CoA dehydrogenase: dehydrogenase dGDP pyruvate ATP a reduced de novo biosynthesis succinate glutamyl-meso-2,6- trehalose 6- biotin peptide- cytochrome palmitate biosynthesis de novo biosynthesis I 2-dehydro-3- mutase: scpA lpdA (acetyl- H O c-type PRPP UDP CTP uracil methionine 2 (type II fatty acid synthase) fatty acid elongation -- saturated dehydrogenase deoxy-D-gluconate transferring) diaminopimeloyl- phosphatebifunctional gln ribonucleoside- dihydrolipoyl nitronate lytic DUF3857 and bifunctional CcoN cytochrome hydrogencarbonate IMP bifunctional pyr operon flavoprotein: succinyl-CoA E1 component O-acetylhomoserine D-alanine alpha,alpha- (S)-S-oxide an oxidized IMP asp amidophosphoribosyltransferase: diphosphate dehydrogenase: L-idonate monooxygenase: transglycosylase transglutaminase rhamnulose- transcriptional regulator/uracil shikimate AAY42_RS12135 NADH repair (prokaryotes) subunit aminocarboxypropyltransferase/ trehalose- biotin--[acetyl- reductase O c-type an acetoacetyl-[acp] CDP a [pyruvate dehydrogenase a [pyruvate dehydrogenase degradation AAY42_RS05905 domain-containing pyruvate 1-phosphate 2 an acetoacetyl-[acp] IMP AAY42_RS13275 reductase: phosphoribosyltransferase AAY42_RS12140 lpdA pyruvate cysteine synthase: domain-containing CoA-carboxylase] MsrA: msrA cytochrome carbamoyl- E2 protein] N 6 - E2 protein] Nalpha: 6pdhA-S- LD- protein: phosphate kinase: pyk aldolase/ dehydrogenase: 5-phospho-β- AAY42_RS11670 ribonucleoside- PyrR: pyrR shikimate kinase: dehydrogenase AAY42_RS08280 nitronate protein: RS06170 phosphate adenylosuccinate gly L-idonate carboxypeptidase: AAY42_RS01870 synthase (UDP- ligase: peptide- 3-oxoacyl- guaB AAY42_RS11675 UMP AAY42_RS06210 succinate NADH KDGP dihydrolipoyl-L-lysine complex acetyldihydrolipoyl-L-lysine monooxygenase: AAY42_RS08150 short-chain D-ribosylamine diphosphate cysteine synthase AAY42_RS06025 forming)/trehalose- AAY42_RS07195 methionine [acyl-carrier- synthase synthase: dUDP propanoyl-CoA dihydrolipoamide endolytic dehydrogenase: reductase: CysM: cysM AAY42_RS13580 phosphatase: protein] large AAY42_RS00595 UMP kinase: shikimate 3- acetyltransferase: pyruvate AAY42_RS16415 (S)-S-oxide XMP phosphoribosylamine- AAY42_RS11670 5-dehydro- transglycosylase a [protein] N 6 - reductase: subunit: carB nucleoside- AAY42_RS09310 phosphate UDP-N-acetyl-α-D- trehalose-AAY42_RS01710 dGTP biotinyl-5'- reductase -glycine ligase: purD AAY42_RS11675 xanthine and bifunctional AAY42_RS15795 D-gluconate [unspecified MltG: mltG [(5-hydroxy-1H- fabG a 3-oxoacyl-[acp] diphosphate UDP 3-phosphoshikimate 1- 4-hydroxy-2- D-ala muramoyl-L-alanyl- trans-methoxy- adenylate MsrA: msrA glutamine- glutamine- adenylo-succinate phosphoribosylamine- xanthosine salvage acetate 3-oxopropanoate nitrite degradation indol-3-yl)ethyl]- a protein-L- kinase: dCDP carboxyvinyltransferase: gluconate 5- L-selenocysteine γ-D-glutamyl-meso- mono-mycolate RS10540 hydrolyzing (R)-NADHX oxoglutarate GlcNAc-1,6- DHAP (S)-lactaldehyde methionine- a (3R)-3- hydrolyzing GMP -glycine ligase: purD AAY42_RS00660 nucleoside-diphosphate dehydrogenase: products] a lipid II L-glutamine nucleoside- AAY42_RS08130 bifunctional aldolase/2- 2,6-diaminopimelate (S)-S-oxide hydroxybutanoyl-[acp] carbamoyl- synthase: guaA adenylosuccinate kinase: AAY42_RS00660 5-enolpyruvoyl- AAY42_RS08750 anhydro-MurNAc- phosphate : purB dUTP diphosphate xanthosine ADP-dependent dehydro-3-deoxy- acetyl-CoA pentapeptide UTP shikimate 3- gluconate 5- bifunctional GAR kinase: purine-nucleoside NAD(P)H-hydrate phosphogluconate 3-oxoacyl- synthase GMP dUTP phosphate UDP-3-O-[3- AAY42_RS00660 CTP synthase: phosphorylase: (S)-methylmalonyl-CoA succinyl-CoA aldolase: dehydrogenase: [acyl-carrier- small diphosphatase: chorismate dehydratase/ a [ribosomal a 1-acyl-2- a protein-L- hydroxymyristoyl] N- AMP phosphoribosylglycinamide AAY42_RS07680 AAY42_RS16475 7,8-dihydrofolate + hydrogen a nucleoside phosphoenol beta- protein] subunit: carA dut AAY42_RS05925 AAY42_RS14960 NAD(P)H-hydrate a sulfurated NADPH H a (6S)-5- a reduced aci-nitroethane a cytidine 34 RS14535 acetylglucosamine formyltransferase: purN dCTP xanthine synthase: protein S12] monoglutamate glu peroxide RNA pyruvate arachidonoyl- lys methionine- guanylate methylmalonyl-CoA epimerase: [ carrier] thioredoxin triphosphate dADP Ile2 ketoacyl- reductase: [+ 2 isozymes] CTP aroC D-gluconate L-aspartate 89 formyltetrahydrofolate sn-glycerol in tRNA (R)-S-oxide deacetylase/3- kinase: gmk mutase subunit beta: AAY42_RS05465 D-glyceraldehyde pyruvate fermentation to acetate IV mevalonate degradation peptide- ACP fabG carbamoyl adenylate kinase: FGAR (S)-NADHX pyruvate 3-phosphate CTP hydroxyacyl-ACP asp dUMP AAY42_RS00755 3-phosphate gluconokinase: dihydrofolate nitronate methionine synthase phosphate AAY42_RS17985 chorismate thioredoxin- DNA-directed dehydratase: a (3R)-3- methylmalonyl- AAY42_RS02505 30S ribosomal reductase: bifunctional monooxygenase: tRNA (R)-S-oxide a 2,3,4-saturatedII: fabF beta-hydroxyacyl- GDP phosphoribosylformylglycinamidine thymidylate bifunctional pyruvate (R)-mevalonate dependent RNA polymerase AAY42_RS04120 hydroxyacyl-[acyl- methylmalonyl-CoA CoA mutase: scpA protein S12 AAY42_RS08600 folylpolyglutamate AAY42_RS05905 pyruvate lysidine(34) reductase ACP dehydratase: synthase: purL synthase: ADP-dependent D-gluconate thiol fatty acyl-[acp] aspartate ADP epimerase: mce methylthiotransferase synthase/ subunit omega: kinase: pyk synthetase MsrB: msrB RS04295 beta-hydroxyacyl- carrier protein] AAY42_RS08355 XMP NAD(P)H-hydrate hydroxymethylglutaryl-CoA 6-phosphate dihydrofolate nitronate AAY42_RS03510 carbamoyltransferase RimO: rimO dihydrofolate peroxidase: AAY42_RS02450 TilS: tilS ACP dehydratase: FGAM (R)-methylmalonyl-CoA reductase, degradative: reductase: monooxygenase: peptide- catalytic subunit: nucleoside- ribonucleoside- dTMP pyrimidine ribonucleosides salvage I dehydratase/ D-gluconate synthase: bcp [+ 2 isozymes] AAY42_RS03510 bifunctional ribonucleoside- AAY42_RS15040 AAY42_RS08410 AAY42_RS13580 methionine AAY42_RS05655 diphosphate diphosphate Secondary Metabolite Biosynthesis NAD(P)H-hydrate degradation AAY42_RS15725 peroxiredoxin: a CDP-1-acyl- UDP-3-O-[3- diphosphate phosphoribosylformylglycinamidine pyruvate fermentation a [ribosomal pyruvate a lysidine 34 (R)-S-oxide kinase: reductase: cytidine epimerase: acetyl-CoA formate HMG-CoA 5'-deoxyadenosine an unsulfurated AAY42_RS17695 dATP 2-arachidonoyl- a (2E)-but-2-enoyl-[acp] hydroxymyristoyl] N- reductase: cyclo-ligase: AAY42_RS17375 to (R)-acetoin II D-gluconate met protein S12]-3- in tRNA Ile2 reductase AAY42_RS00660 AAY42_RS11670 AAY42_RS05465 [sulfur carrier] 5,6,7,8- RNA glycerol acetylglucosamine AAY42_RS11670 fluoroacetate and methylsulfanyl- + RS08520 N-carbamoyl- dTDP uridine nucleoside preQ biosynthesis gluconokinase: phosphate NADP a (6S)-5- acetaldehyde nitrite MsrB: msrB deacetylase/3- AAY42_RS11675 AAY42_RS11675 0 pyruvate 89 tetrahydrofolate a [protein]-L- L-aspartate AIR kinase: udk fluorothreonine biosynthesis NADH AAY42_RS02505 acetyltransferase: pta hydroxymethylglutaryl-CoA L-aspartate formyltetrahydrofolate an oxidized H O nucleoside- deaminase: biosynthetic-type 2 hydroxyacyl-ACP D-gluconate thioredoxin methionine dihydroorotase: AAY42_RS11570 lyase: AAY42_RS17795 dehydratase: GTP dADP diphosphate fluoride acetolactate 6-phosphate AAY42_RS04390 CMP GTP acetyl phosphate hydroxymethylglutaryl-CoA AAY42_RS04120 dGDP kinase: cytidine synthase: ilvB ilvN a butanoyl-[acp] a trans-2- lyase: AAY42_RS00125 dihydroorotase: AAY42_RS00660 deaminase: SAM-dependent GTP (S)-2-acetolactate DNA with adenine:7,8- 6-O-trans-keto- 6-O-α-mycolyl- an N-terminal- a 2,3,4-saturated nucleoside- a 5,10- a 2-thiouridine 34 quinoxaline-2- sn-glycero-3- a [protein]- a peptide with a supercoiled enoyl-[acyl- AAY42_RS14465 AAY42_RS15785 chlorinase/ cyclohydrolase acetate kinase: FAD dihydro-8- trehalose 6- L-methionyl-L- RS12865 beta-ketoacyl- fatty acyl-[acp] nucleoside- diphosphate superpathway of pyrimidine deoxyribonucleoside salvage dTTP acetolactate ATP methylenetetrahydrofolate in tRNA aryl-carrier protein carboxyl adenylate phospho-N- L-threonine mycolyl-trehalose an N-terminal duplex DNA carrier protein] fluorinase: I FolE: folE AAY42_RS00930 acetyl-CoA oxoguanine mismatch phosphate seryl-[protein] (S)-dihydroorotate diphosphate kinase: decarboxylase: biosynthesis acetoacetate (arachidonoyl) 6-phosphate L-methionine DNA ACP synthase uridine AAY42_RS04935 bifunctional bifunctional kinase: AAY42_RS00660 2'-deoxycytidine GTP ethanolamine helicase II: fabF AAY42_RS16555 acetate tRNA uridine-5- FAD:protein FMN alpha,alpha- alpha,alpha- AAY42_RS00660 inosine-5'-phosphate biosynthesis I uridine 5'-deoxy-5'- cyclohydrolase type I methionyl type I methionyl RecQ: quinone-dependent 7,8- acyl carrier protein: : A/G-specific trehalose- trehalose- kinase: udk fluoroadenosine I FolE: folE (R)-acetoin ADP Detoxification carboxymethylaminomethyl(34) recQ a 3-oxohexanoyl-[acp] dihydroorotate dATP nucleoside dihydroneopterin AAY42_RS03520 glycerophosphodiester adenine phosphate phosphate aminopeptidase: aminopeptidase: CDP-diacylglycerol biotin-carboxyl carrier protein assembly purine-nucleoside F0F1 ATP synthesis GTPase MnmE: mnmE AAY42_RS17390 dehydrogenase: dGTP deaminase: AIR acyl carrier protein: phosphodiesterase: glycosylase: synthase (UDP- synthase (UDP- map map ATP- RS15345 biosynthesis I UMP 3'-triphosphate Fatty Acid and FAD:protein FMN 3-oxoacyl- AAY42_RS11570 5-(carboxyamino)imidazole phosphorylase: synthase: atpG reactive oxygen species degradation tRNA uridine-5- AAY42_RS14745 mutY dependent AAY42_RS00110 dCMP 6-carboxytetrahydropterin arsenate AAY42_RS13295 forming)/trehalose- forming)/trehalose- [acyl-carrier- a [biotin carboxyl- ribonucleotide synthase: AAY42_RS14960 AAY42_RS12305 Lipid Degradation arsenate carboxymethylaminomethyl(34) transferase: cytidine deaminase: detoxification V phosphatase: phosphatase: an N-terminal DNA DHAP carrier protein]-L-lysine quinone-dependent (d)CMP kinase: 5-fluoro-5-deoxy-D- synthase: AAY42_RS15760 atpH detoxification synthesis enzyme MnmG: mnmG AAY42_RS07460 protein] AAY42_RS15785 AAY42_RS15910 oleate β-oxidation superoxide AAY42_RS01710 AAY42_RS01710 met met a peptide helicase biotin--[acetyl-CoA- dihydroorotate AAY42_RS05690 N5-CAIR 6-carboxytetrahydropterin AAY42_RS12315 II (glutaredoxin) a quinoxaline-2- sn-glycerol an apurinic site trehalose- L-seryl-[protein] reductase: ribose 1-phosphate arsenate anandamide α, α'-trehalose RecG: recG carboxylase] ligase: dehydrogenase: synthase: AAY42_RS06825 atpE atpB superoxide AMP carboxyl-[aryl- 3-phosphate adenine within DNA trans-keto- a single fabG purine deoxyribonucleosides salvage 2'-deoxyuridine dCDP arsenate glyceraldehyde- a 5-aminomethyl-2- a [protein]-FMN- 6-α-mycolate RS12985 sn-glycerol AAY42_RS07195 AAY42_RS17780 6-carboxy-5,6,7,8- oleate a 7,8-dihydrofolate carrier protein] mono-mycolate 5-(carboxyamino)imidazole F0F1 ATP dismutase: arsenate reductase thiouridine 34 in tRNA L-threonine stranded DNA a (3R)-3- 3-phosphate PRPP 2-oxoglutarate decarboxylation to succinyl-CoA Respiration 3-phosphate AMP a [biotin carboxyl-carrier orotate nucleoside- ribonucleotide mutase: purE tetrahydropterin AAY42_RS13270 (glutaredoxin): arsC hydroxyhexanoyl-[acp] thymidine kinase: synthase: long-chain fatty dehydrogenase: protein]-N 6 -biotinyl-L-lysine diphosphate kinase: 5-fluoro-5-deoxy-D- 7-carboxy-7- 2'-deoxyguanosine 2'-deoxyadenosine AAY42_RS12775 a [2-oxoglutarate AAY42_RS13990 acid--CoA ligase: hydrogen arsenate reductase: AAY42_RS02315 bifunctional AAY42_RS00660 CAIR ribulose 1-phosphate deazaguanine 1-arseno-3- deoxynucleoside deoxynucleoside deoxynucleoside dehydrogenase AAY42_RS13995 AAY42_RS01745 peroxide AAY42_RS13605 thymidine phosphoglycerate 4 β UDP-3-O-[3- a 1-acyl-sn dCTP synthase QueE: 6 ATP arsenite UDP-N-acetyl-α-D-muramoyl- a glucosylated a 2'- a 3-(acyloxy) N -( -N-acetyl- 6-O-cis-methoxy- a mismatched a [lipoyl-carrier kinase: kinase: kinase: E2 protein] N 2-oxoglutarate di-trans,octa-cis- UDP-α-D-glucose N-formyl- phosphoribosylaminoimidazolesuccinocarboxamide 6 sec RS12890 hydroxymyristoyl] N- -glycerol 3- AAY42_RS16345 -lipoyl-L-lysine oleoyl-CoA catalase/ L-alanyl-γ-D-glutamyl-L- glycogenin deoxyribonucleoside [DNA] acyl group of D-glucosaminyl) mycolyl-trehalose DNA base pair protein]-N -[(R) ser a tRNA a [biotin carboxyl-carrier-protein orotidine 5'- AAY42_RS08300 AAY42_RS08300 AAY42_RS08300 synthase: AAY42_RS04925 dehydrogenase undecaprenyl phosphate L-glutamate acetylglucosamine phosphate thymidine kinase: 7-carboxy-7- peroxidase lysyl-D-alanyl-D-alanine 5'-triphosphate bacterial toxin -L-asparagine 6-phosphate DNA mismatch -dihydrolipoyl]- 6 phosphate dGMP dAMP 2-oxoglutarate bifunctional dimer]-N -biotinyl-L-lysine AAY42_RS12775 fluoroacetaldehyde E1 component: acyl-CoA repair deacetylase/3- 1-acyl-sn-glycerol- deazaguanine dehydrogenase HPI: katG glycogen/starch alpha,alpha- L-lysine dihydrolipoyl dUMP SAICAR AAY42_RS09400 dehydrogenase: H O hydroxyl radical 1-arseno-3- hydroxyacyl-ACP 3-phosphate deoxynucleoside 2 protein MutS: dehydrogenase: acetyl-CoA orotidine-5'- E1 component: phosphoglycerate phospho-N- synthase: DNA polymerase acyloxyacyl N(4)-(beta-N- trehalose- N-formylglutamate serine- dehydratase: acyltransferase: kinase: adenine and AAY42_RS15700 arsenite AAY42_RS03425 carboxylase biotin phosphate adenylosuccinate AAY42_RS09400 O acetylmuramoyl- AAY42_RS16215 III subunit alpha: hydrolase: acetylglucosaminyl) phosphate amidohydrolase: lpdA -tRNA AAY42_RS04120 AAY42_RS17725 acetyl-CoA thymidylate AAY42_RS08300 adenosine salvage I (2E,9Z)- 2 carboxylase subunit: decarboxylase: lyase: purB pentapeptide- glycogen/starch AAY42_RS10215 AAY42_RS00945 -L-asparaginase: synthase (UDP- DNA AAY42_RS03355 dihydrolipoyl ligase: RS12860 carboxylase synthase: [+ 2 isozymes]a [2-oxoglutarate a [2-oxoglutarate octadecenoyl-CoA beta-hydroxyacyl- [+ 2 isozymes] AAY42_RS00775 pyrF preQ transferase: synthase: [+ 8 isozymes] acyloxyacyl AAY42_RS09190 forming)/trehalose- mismatch dehydrogenase: serS a 1,2-diacyl- carboxyltransferase AAY42_RS08355 0 dehydrogenase dehydrogenase AICAR fluoroacetate 6 6 AAY42_RS07995 phosphatase: repair protein a [lipoyl-carrierlpdA ACP dehydratase: subunit beta: acetyl-CoA UMP dGDP dADP adenosine 4-fluorothreonine E2 protein] N E2 protein] N -S- AAY42_RS13965 hydrolase: sn-glycerol MutS: mutS formate protein]-N 6 -[(R AAY42_RS03510 carboxylase purine-nucleoside -dihydrolipoyl- succinyldihydrolipoyl- AAY42_RS08225 β trehalose-AAY42_RS01710 glu 3-phosphate AAY42_RS07570 UMP kinase: bifunctional Secondary Metabolite Degradation [DNA] N-acetyl- - a properly matched )-lipoyl]-L-lysine an L-seryl- biotin carboxylase nucleoside- nucleoside- phosphorylase: undecaprenyl-diphospho-N- UMP asp phosphoribosylaminoimidazolecarboxamide L-lysine L-lysine (S)-3-hydroxy-(9Z) a glucosylated glucosaminylamine cis-methoxy- sec a (2E)-hex-2-enoyl-[acp] AAY42_RS09310 γ UDP DNA base pair [tRNA ] subunit: accC diphosphate diphosphate AAY42_RS14960 -octadecenoyl-CoA acetylmuramoyl-L-alanyl- -D- glycogenin a 3-hydroxyacyl mono-mycolate SecG CMP formyltransferase/IMP cyclohydrolase: purH anhydromuropeptides recycling I a [carboxyl-carrier protein dimer]- UDP kinase: kinase: adenine glutamyl-L-lysyl- D-alanyl-D-alanine group of a fatty acid phosphorylation 6 AAY42_RS00660 FAICAR a CDP- N -carboxybiotinyl-L-lysine nucleoside- AAY42_RS00660 2-oxoglutarate GlcNAc-1,6-anhMurNAc- bacterial toxin diacylglycerol CMP dTMP adenine diphosphate bifunctional dehydrogenase L-Ala-γ-D-Glu-DAP-D-Ala dGTP dATP (d)CMP kinase: phosphoribosyltransferase: 3-oxo-(9Z)- kinase: E1 component: UDP-N-acetyl-α-D- an N-terminal- 6-O-cis-keto- an N-terminal- AAY42_RS05690 phosphoribosylaminoimidazolecarboxamide AAY42_RS17330 octadecenoyl-CoA di-trans,octa-cis- O-succinyl-L- O-phospho- a hexanoyl-[acp] AAY42_RS00660 AAY42_RS09400 γ cys 2-oxoglutarate isochorismate L-methionyl-L- mycolyl-trehalose L-methionyl-L- cys γ-L-glutamyl- gly GGPP GGGP gln CDP formyltransferase/IMP cyclohydrolase: purH muramoyl-L-alanyl- -D- dGTP RS05050 acetyl-CoA C- undecaprenyl phosphate homoserine cysteinyl-[protein] 6-phosphate alanyl-[protein] L-homoserine D-alanine long-chain fatty UTP dTDP AMP 2-oxoglutarate glutamyl-L-lysyl-D-alanine beta-ketoacyl- fatty acid biosynthesis nucleoside- acyltransferase: N-acetyl-β-D-glucosamine- bifunctional acid activation dehydrogenase L-alanyl-γ-D-glutamyl-meso- ACP synthase initiation (type II) diphosphate nucleoside- IMP AAY42_RS05430 1,6-anhydro-N- 2-succinyl-5- alpha,alpha- CTP synthase: complex 2,6-diaminopimeloyl-D-alanine phospho-N- cystathionine type I methionyl type I methionyl cystathionine glutathione II: fabF a long-chain kinase: diphosphate kinase: acetyl-CoA C- acetyl-β-D-muramate enolpyruvyl- trehalose- AAY42_RS05925 dihydrolipoyllysine- LD- acetylmuramoyl- dNTP gamma-synthase: aminopeptidase: aminopeptidase: gamma-synthase: synthase: acetyl-CoA fatty acid AAY42_RS00660 AAY42_RS00660 acyltransferase: glcNAc-1,6- 6-hydroxy-3- phosphate a 3-oxooctanoyl-[acp] long-chain fatty residue carboxypeptidase: pentapeptide- triphosphohydrolase: dgt AAY42_RS13630 map map AAY42_RS13630 gshB acetyl-CoA AAY42_RS01730 anhMurNAcaminidase: cyclohexene-1- synthase (UDP- RS08950 acid--CoA ligase: CTP CTP dTTP succinyltransferase: AAY42_RS06025 transferase: carboxylase AAY42_RS00800 carboxylic-acid forming)/trehalose- 2,3-bis-O- 3-oxoacyl- AAY42_RS01745 odhB γ AAY42_RS07995 carboxyltransferase a long-chain (7Z)-hexadecenoyl-CoA L-alanyl- -D-glutamyl- synthase: menD an N-terminal L- phosphatase: an N-terminal L- (geranylgeranyl) [acyl-carrier- 1,6-anhydro-N- succinate met met norophthalmate subunit beta: fatty acyl-CoA meso-diaminopimelate triphosphate L-cystathionine cysteinyl-[protein] AAY42_RS01710 alanyl-[protein] L-cystathionine -sn-glycerol protein] acyl-CoA acetyl-β-muramate undecaprenyl-diphospho-N 2'-deoxyguanosine trehalose-cis-keto- AAY42_RS07570 UMP 2-succinyl-5-enolpyruvoyl- 1-phosphate reductase: dehydrogenase: anhydro-N- -acetylmuramoyl-L-alanyl-γ- mono-mycolate malonyl-CoA 6-hydroxy-3-cyclohexene- fabG 2-oxoisovalerate decarboxylation to isobutanoyl-CoA AAY42_RS15700 acetylmuramic D-glutamyl-L-lysyl- D-alanine RS16270 1-carboxylate ACP S- Carbohydrate Biosynthesis (2E,7Z)- acid kinase: a (3R)-3- Tetrapyrrole Biosynthesis an [apo BCAA malonyltransferase: hexadecenoyl-CoA AAY42_RS00790 hydroxyoctanoyl-[acp] dehydrogenase fabD gluconeogenesis I an N 6 -L- a [DNA]-3'- a 5'-phospho- lipid II (meso 3-benzyl-3,6 - a 2,3,4-saturated an N-terminal- UDP-N-acetyl-D- glycogen biosynthesis I (from ADP-D-Glucose) E2 protein] N 6 N-acetyl-D-muramate a sulfurated NAD + a D-tyrosyl- 15-cis-phytoene bifunctional tetrapyrrole biosynthesis alpha-ketoacid threonylcarbamoyladenine 37 diaminopimelate bis(cysteinylglycine) 1,2-diacyl-sn L-methionyl-L- Cell Structure Biosynthesis heme b biosynthesis glucosamine biosynthesis I 6-phosphate [sulfur carrier] hydroxyl [DNA] [tRNA Tyr ] GTP dGDP Na + RS08315 Na + UDP-3-O-[3- a malonyl-[acp] I (from glutamate) siroheme biosynthesis -lipoyl-L-lysine dehydrogenase in tRNA containing) - 6-(hydroxymethyl) -glycerol 3- valyl-[protein] phytoene I (aerobic) (S)-malate ribonucleoside- hydroxymyristoyl] N- D-glucopyranose D-glucopyranose 6-phosphate dihydrolipoyl subunit alpha/beta: (S)-3-hydroxy-(7Z) N-acetylmuramic -diketopiperazine phosphate CTP nucleoside triphosphate desaturase: ketoacyl-ACP peptidoglycan biosynthesis I (meso-diaminopimelate containing) 6-phosphate dehydrogenase: AAY42_RS03235 -hexadecenoyl-CoA acid 6-phosphate NAD- pyrophosphohydrolase: diphosphate crtI acetylglucosamine lipid IV biosynthesis (E. coli) glu uroporphyrinogen-III uroporphyrinogen-III glucose-6- peptidoglycan D-tyrosyl-tRNA(Tyr) type I methionyl A phospho- lpdA etherase: murQ tRNA (N(6)-L- dependent mazG reductase: deacetylase/3- synthase III: glutamate-- uroporphyrinogen-III C- malate dehydrogenase: mdh synthetase: deacylase: aminopeptidase: phytoene NADH:ubiquinone UDP-N-acetyl- uroporphyrinogen phosphate sugar mutase: threonylcarbamoyladenosine(37) DNA ligase membrane AAY42_RS11670 hydroxyacyl-ACP AAY42_RS15855 α a (3R)-3- tRNA ligase: methyltransferase: cobA dihydrolipoyl N-acetyl-D-glucosamine AAY42_RS15960 AAY42_RS08155 nucleotide map desaturase: Na + reductase (Na(+) Na + -D-glucosamine decarboxylase: hemE isomerase: pgi AAY42_RS01810 -C(2))- methylthiotransferase LigA: ligA dipeptidase: AAY42_RS11675 dehydratase: [+ 2 isozymes] hydroxytetradecanoyl- UDP-N-acetyl- AAY42_RS12625 dehydrogenase: 6-phosphate pyrophosphohydrolase: crtI -transporting) UDP-N-acetylglucosamine uroporphyrinogen-III C- coproporphyrinogen III oxaloacetate F6P α an [apo BCAA 3-oxo-(7Z)- MtaB: mtaB AAY42_RS08850 AAY42_RS04120 [acp] α-D-glucosamine an L-glutamyl-[tRNA Glu ] -D-glucopyranose lpdA AAY42_RS08135 GDP 9,15,9'-tri-cis 1-carboxyvinyltransferase: methyltransferase: cobA an [apo BCAA dehydrogenase hexadecenoyl-CoA lipid II (meso di-trans,octa-cis an acetoacetyl-[acp] 1-phosphate dehydrogenase 6 an N-terminal -ζ-carotene precorrin-1 oxygen-dependent glutamine-- E2 protein] N -S-[2- Tyr a CDP-2,3,4- GMP beta-hydroxyacyl- murA E2 protein] N 6 acetyl-CoA C- a 2-methylsulfanyl-N 6 -L- [DNA] NMN diaminopimelate -undecaprenyl 3-benzyl-3,6 - D-tyrosine a tRNA met L-valyl-[protein] acyl-ACP--UDP-N- coproporphyrinogen fructose-6- methylpropanoyl]dihydrolipoyl- saturated- ACP dehydratase: UDP-N-acetyl-α- glutamyl-tRNA phosphoenolpyruvate pyruvate threonylcarbamoyladenine 37 5'-deoxyadenosine an unsulfurated AMP containing) diphosphate bis(cysteinyl)- 6- gly RS12290 acetylglucosamine O- uroporphyrinogen-III C- -dihydrolipoyl- acyltransferase: D-glucosamine 6-phosphate met AAY42_RS03510 reductase: hemA oxidase: hemF carboxykinase (ATP): pckA phosphate L-lysine [sulfur carrier] (hydroxymethyl) diacylglycerol D-glucosamine- acyltransferase: lpxA methyltransferase: cobA L-lysine AAY42_RS05430 in tRNA phosphoenolpyruvate transaminase -diketopiperazine enolpyruvate α glycogen/starch ADP-α-D-glucose a (2E)-oct-2-enoyl-[acp] lipid IV biosynthesis (P. putida) (S)-4-amino-5-oxopentanoate uroporphyrinogen-III C- protoporphyrinogen IX (isomerizing) a (1->4)- -D-glucan acetyl-CoA C- phosphoglucosamine UDP-3-O-[(3R)-3- A carboxykinase (ATP): pckA synthase: UDP-N- methyltransferase: cobA : glmS acyltransferase: mutase: glmM phosphatidylserine and acetylmuramate hydroxymyristoyl]-N- a (3R)-3- glutamate-1- AAY42_RS16215 N 6 -(3-methylbut- 34 an N-terminal- an N-terminal- D-glucosamine 2-oxo acid AAY42_RS01730 (1S,2R)-1- a [protein]-S- a uridine N-acetyl-9-O- phosphatidylethanolamine dehydrogenase: acetyl-α-D-glucosamine hydroxydecanoyl- semialdehyde 2,1- precorrin-2 heme b biosynthesis II α-D-glucosamine 1-phosphate H O UDP-N-acetyl- phosphoenolpyruvate glycogen/starch 2-en-1-yl)- ser C-(indol-3- sulfanyl-L-cysteine in tRNA L-methionyl-L- 2 L-methionyl- RS09320 glu (oxygen-independent) 6-phosphate dehydrogenase a sulfurated [sulfur carrier] acetylneuraminate GTP ITP dADP AMP biosynthesis I murB bifunctional [acp] α aminomutase: hemL (5Z)-tetradecenoyl-CoA adenosine 37 in tRNA threonyl-[protein] glycyl-[protein] -D-glucosamine bifunctional precorrin- synthase: subunit E2: yl)glycerol ala UDP-N-acetyl- UDP-3-O-[3- protoporphyrin IX phosphopyruvate phosphoglucosamine a (1->4)-α-D-glucanAAY42_RS13965 nucleoside triphosphate ribonucleoside- a CDP-diacylglycerol glutamate 2 dehydrogenase/ AAY42_RS06700 acyl-CoA 3-phosphate 5'/3'- an octanoyl-[acp] α-D-muramate hydroxymyristoyl] N- acyl-ACP--UDP-N- 5-aminolevulinate uroporphyrinogen-III hydratase: eno mutase: glmM tRNA 2- sialate O- pyrophosphohydrolase: diphosphate racemase: sirohydrochlorin dehydrogenase: tRNA (N6-isopentenyl type I methionyl type I methionyl nucleotidase acetylglucosamine acetylglucosamine O- ferrochelatase: uroporphyrinogen α 1,4-alpha-glucan α tryptophan thiouridine(34) acetylesterase: GTPase mazG reductase: -D-glucosamine N-acetyl- -D- aminopeptidase: aminopeptidase: SurE: surE beta-ketoacyl- murI porphobilinogen ferrochelatase: hemH decarboxylase: hemE 2-phospho-D-glycerate branching AAY42_RS15700 adenosine(37)-C2)- synthase: trpB synthase AAY42_RS03920 Era: era AAY42_RS11670 a 3-sn-phosphatidyl- UDP-N- deacetylase/3- acyltransferase: lpxA 1-phosphate glucosamine 1-phosphate map nucleotide map ACP synthase amino acid synthase: hemB AAY42_RS10495 protein GlgB: glgB (2E,5Z)- methylthiotransferase AAY42_RS07100 MnmA: mnmA [+ 6 isozymes] AAY42_RS11675 RS09355 L-serine acetylmuramate-- hydroxyacyl-ACP coproporphyrinogen III sialate O- pyrophosphohydrolase: adenosine II: fabF racemase: UDP-3-O-[(3R)-3- protoheme 2,3-bisphosphoglycerate- NADPH repair (prokaryotes) tetradecenoyl-CoA MiaB: miaB L-alanine ligase: dehydratase: a glycogen acetylesterase: AAY42_RS08135 ADP phosphatidylserine AAY42_RS08820 hydroxydecanoyl]- porphobilinogen sirohydrochlorin oxygen-independent independent Glycolysis AAY42_RS07975 AAY42_RS04120 D-glyceraldehyde 34 AAY42_RS06480 an N-terminal L- H + an N-terminal decarboxylase α 6 a [protein]- a 2-thiouridine phosphate IMP a 3-oxodecanoyl-[acp] N-acetyl-α-D- coproporphyrinogen phosphoglycerate N-acetyl- -D- UDP-N-acetyl- N -(3-methylbut-2-en- 3-phosphate trp met threonyl-[protein] GDP met glycyl-[protein] family protein: UDP-3-O-(3- hydroxymethylbilane bifunctional precorrin- NADPH an unsulfurated L-cysteine in tRNA UDP-N-acetyl-α-D- D-glt glucosamine III oxidase: hemN mutase: AAY42_RS07445 glucosamine α-D-glucosamine 5'-deoxyadenosine 1-yl)-2-(methylsulfanyl) met AAY42_RS07220 hydroxymyristoyl) synthase: hemC 2 dehydrogenase/ glycolysis I (from glucose 6-phosphate) [sulfur carrier] 3-oxoacyl- muramoyl-L-alanine α 1-phosphate UDP-N-acetylglucosamine adenosine 37 in tRNA N-acetylneuraminate - -D-glucosamine sirohydrochlorin protoporphyrinogen IX 3-phospho-D-glycerate GDP-L-fucose (3E,5Z)-tetradeca- (S)-3-hydroxy-(5Z) acetate RS17560 [acyl-carrier- an L-1- 1-carboxyvinyltransferase: UDP-3-O-(3- preuroporphyrinogen ferrochelatase: biosynthesis I (from D-glucopyranose 3,5-dienoyl-CoA -tetradecenoyl-CoA protein] phosphatidylethanolamine UDP-N- murA hydroxymyristoyl) UDP-3-O-(3- AAY42_RS10495 phosphoglycerate GDP-D-mannose) 6-phosphate reductase: acetylmuramoyl- uroporphyrinogen- UDP-N-acetyl- UDP-N-acetyl-α-D- an sn-glycero-3- glucosamine N- hydroxydecanoyl) kinase: AAY42_RS12575 GDP-α-D-mannose (R)-NADPHX a mature peptidoglycan (meso N-acetyl-4-O- a (1->4)- fabG L-alanine-- siroheme α-D-glucosamine glucose-6- glucosamine-enolpyruvate 3-methylbutanoate leukotriene-D4 Ala carbonic acid acetyl-CoA α acyltransferase: -α-D-glucosamine III synthase: GDP-mannose bifunctional -diaminopimelate containing) phospho-N-(acyl) acetylneuraminate a glycyl-[tRNA ] a mercapturate -D-glucan D-glutamate AAY42_RS14445 phosphate ADP-dependent (3E,5Z)- 3-oxo-(5Z)- ethanolamine acetyl-CoA 1,4-alpha- a (3R)-3- AAY42_RS04105 UDP-3-O-(3- protoporphyrin IX 13-DPG dTDP-β-L-rhamnose 4,6-dehydratase: UDP-N- ligase: murD isomerase: pgi NAD(P)H-hydrate tetradecadienoate tetradecenoyl-CoA carboxylase glucan RS06285 hydroxydecanoyl-[acp] UDP-3-O-(3- hydroxymyristoyl) uroporphyrinogen- biosynthesis gmd acetylmuramate lytic transglycosylase GDP-4-dehydro- dehydratase/ acetate- sialate O- membrane carbonic anhydrase: biotin carboxyl: branching UDP-N-acetyl- hydroxymyristoyl) glucosamine N- III synthase: ferrochelatase: type I glyceraldehyde- acetyl-CoA C- dehydrogenase: domain-containing glycerophosphodiester D-tyrosyl-tRNA(Tyr) bifunctional α-D-glucopyranose α-D-rhamnose -CoA acetylesterase: dipeptidase: AAY42_RS10920 acylase: protein α acyltransferase: AAY42_RS11885 hemH 3-phosphate trehalose biosynthesis I F6P NAD(P)H-hydrate acyltransferase: murB phosphodiesterase: deacylase: AAY42_RS00770 meso-diaminopimelate -D-muramoyl-L- glucosamine N- protein: AAY42_RS01870 ligase: acs AAY42_RS03920 AAY42_RS08850 UDP-3-O-[3- AAY42_RS04105 1-phosphate GDP-L-fucose epimerase: AAY42_RS01730 carbonic anhydrase: AAY42_RS14595 AAY42_RS00775 GlgB: glgB alanyl-D-glutamate acyltransferase: triose-phosphate dehydrogenase: gap glucose-1-phosphate UDP-N-acetyl-α-D-muramate AAY42_RS14745 AAY42_RS08155 α hydroxymyristoyl] N- uroporphyrinogen-III protoheme D-glucopyranose synthase: AAY42_RS05465 endolytic transglycosylase sialate O- AAY42_RS13375 a (1,6)- -D- lpxD UDP-3-O-(3- isomerase: [+ 2 isozymes] UDP-α-D-glucose thymidylyltransferase acetyl-CoA C- [+ 4 isozymes] acetylglucosamine 6-phosphate AAY42_RS05045 class 1 fructose- 6-phosphofructokinase: (S)-NADPHX MltG: mltG 3-methylbutanoyl- acetylesterase: glucosyl-(1,4) UDP-N- UDP-2-N,3-O-bis[(3R)- hydroxymyristoyl) AAY42_RS17030 RfbA: rfbA acyltransferase: leukotriene-E4 malonyl-CoA α RS12880 deacetylase/3- DHAP D-glyceraldehyde 3-phosphate GDP-4-dehydro-6- bisphosphatase: fbp pfkA CoA diphosphate sn-glycerol an N- AAY42_RS06480 gly acetate an L-cysteine- - -glucan acetylmuramoyl- 3-hydroxytetradecanoyl]- glucosamine N- dTDP-α-D-glucose AAY42_RS05430 AMP a tRNA Ala hydroxyacyl-ACP deoxy-β-L-galactose bifunctional a mature peptidoglycan with (L- a mature peptidoglycan strand 3-phosphate acylethanolamine gly CO H O S-conjugate L-alanyl-D- α-D-glucosamine acyltransferase: bifunctional (3Z)-dodec- UDP-N-acetyl-α-D-muramoyl- 2 2 dehydratase: dTDP-glucose 4,6- GDP-L-fucose class II fructose-β-D-fructose 1,6- ADP-dependent alanyl-γ-D-glutamyl-meso-2,6- (non-reducing terminus) glutamate--2, 6- UDP-2,3- lpxD alpha,alpha- 3-enoyl-CoA L-alanyl-γ-D-glutamyl- AAY42_RS04120 dehydratase: rfbB synthase: bisphosphate bisphosphate NAD(P)H-hydrate diaminopimeloyl-D-alanine) tetrapeptide acetate N-acetylneuraminate diaminopimelate diacylglucosamine UDP-2-N-[(3R)-3- trehalose- aldolase: meso-2,6-diaminopimelate beta-hydroxyacyl- D-ala class II fructose- dTDP-4-dehydro-6- AAY42_RS05045 dehydratase/ ligase: diphosphatase: hydroxydodecanoyl]- phosphate α AAY42_RS13210 RS12960 ACP dehydratase: bisphosphate aldolase: deoxy- -D-glucopyranose NAD(P)H-hydrate AAY42_RS08000 AAY42_RS03335 3-O-[(3R)-3- synthase (UDP- GDP-β-L-fucose dTDP-4- class II fructose- epimerase: a [2-oxoglutarate- 3 a 2'- a [protein] N- a [LuxE]-S- AAY42_RS03510 D-alanine--D- AAY42_RS13210 forming)/trehalose- (2E)-dodec- an N -methyladenine a D-aspartyl- UDP-2,3- hydroxydecanoyl]- dehydrorhamnose AAY42_RS05465 a sulfurated 2-methylbutanoate alanine ligase: DHAP bisphosphate SAM dehydrogenase in DNA deoxyribonucleoside terminal-formyl- asp (long-chain fatty L-kynurenine a protein UDP-N-acetyl-α-D- α-D-glucosamine class II fructose- phosphatase: 2-enoyl-CoA [sulfur carrier] [DNA] [tRNA ] IMP diacylglucosamine 3,5-epimerase: rfbC aldolase: fbaA E2 protein] N 6 - 5'-triphosphate L-methionine acyl)-L-cysteine a (2E)-dec-2-enoyl-[acp] AAY42_RS07155 muramoyl-L-alanyl- bisphosphate aldolase: fbaA AAY42_RS01710 ATP-dependent diphosphatase: UDP-2,3- dTDP-4-dehydro- NADPH octanoyl-L-lysine γ-D-glutamyl-meso- Clp protease 5'/3'- D-alanyl-D-alanine AAY42_RS13110 diacylglucosamine β-L-rhamnose triose-phosphate acetate- DNA-3- α,α-trehalose DNA peptide D-tyrosyl-tRNA(Tyr) acyl-CoA proteolytic subunit: nucleotidase RS06390 2,6-diaminopimelate diphosphatase: isomerase: Metabolic Clusters lipoyl -CoA methyladenine kynureninase: UDP-α-D- 6-phosphate dTDP-4- (S)-3- polymerase deformylase: deacylase: reductase: AAY42_RS07325 SurE: surE lipid X AAY42_RS03335 PRPP biosynthesis AAY42_RS17030 synthase: ligase: acs glycosylase I: kynU UDP-N- β-D-fructose 1,6-bisphosphate galactose dehydrorhamnose hydroxydodecanoyl-CoA III subunit AAY42_RS00305 AAY42_RS08155 AAY42_RS04235 [+ 2 isozymes] bifunctional N-end rule pathway I (prokaryotic) Alcohol Degradation lipA AAY42_RS14295 a decanoyl-[acyl- acetylmuramoyl- lipid-A- UDP-2,3- biosynthesis reductase: rfbD delta: holA inosine alpha,alpha- D-ribose 5- (2S)-2- a peptide carrier protein] tripeptide--D- disaccharide diacylglucosamine class 1 fructose- β D-glyceraldehyde [+ 6 isozymes] UDP-α-D-glucose trehalose- dTDP- -L-rhamnose phosphate leucyl/phenylalanyl- a [2-oxoglutarate methylbutanoyl- diphosphate an N-terminal L- a [LuxE]- a long-chain anthranilate synthase: lpxB diphosphatase: bisphosphatase: fbp glycerol and glycerophosphodiester degradation an unsulfurated an apurinic site formate asp ala beta-ketoacyl- alanyl-D- alanine ribose-phosphate 3-phosphate tRNA--protein 5'-deoxyadenosine met dehydrogenase AMP 3-methyladenine tRNA D-aspartate AAY42_RS13110 UDP-glucose phosphate CoA within DNA methionyl-[protein] L-cysteine fatty aldehyde RS14360 ACP synthase ligase: murF lipid A disaccharide pyrophosphokinase: 3-oxododecanoyl-CoA 6 [sulfur carrier] F6P 4-epimerase synthase (UDP- type I transferase: E2 protein] N II: fabF (E. coli) AAY42_RS10630 AAY42_RS14280 a [protein] glycerol -lipoyl-L-lysine [DNA] lipid X (P. putida) GalE: galE forming)/trehalose- glyceraldehyde- an N-terminal acetyl-CoA C- UDP-N-acetyl-α-D- α PRPP N-terminal L- glucose-6-phosphate UDP- -D-galactose phosphatase: 3-phosphate arginyl-[protein] a 3-oxododecanoyl-[acp] leucyl-L-arginine acyltransferase: muramoyl-L-alanyl- lipid-A- isomerase: pgi dehydrogenase: γ AAY42_RS01710 AAY42_RS05430 α trans,octacis an unstable -D-glutamyl-meso- disaccharide gap GDP- -D- D-xylulose D-erythrose a [protein]- α a negatively (S)-1-pyrroline- 3-oxoacyl- di-trans,octa-cis- lipid IV (E. coli) acetyl-CoA C- -decaprenyl a [protein]-L-lysine CTP -Kdo a folate RecA filament- RS00225 2,6-diaminopimeloyl- A synthase: lpxB D-glucopyranose 6-phosphate α,α-trehalose leucyl/phenylalanyl- a glycerophosphodiester glycerol mannose DL-allothreonine 5-phosphate 4-phosphate L-glutamine supercoiled DNA 5-carboxylate undecaprenyl phosphate [+ 2 isozymes] acyltransferase: dGTP L-glutamate [acyl-carrier- D-alanyl-D-alanine lipid A Metabolic Regulator tRNA--protein phosphate dihydrofolate DNA gyrase/ DNA complexDNA protein] AAY42_RS01730 nucleoside triphosphate reductase: gamma- disaccharide Biosynthesis transferase: 3-deoxy-manno- topoisomerase repair transketolase: DUF3857 and reductase: phospho-N- (P. putida) 13-DPG AAY42_RS14280 a [protein] glycerophosphodiester glycerol polyprenol pyrophosphohydrolase: AAY42_RS08410 IV subunit A: semialdehyde an N-terminal decanoyl-CoA serine AAY42_RS06180 octulosonate protein fabG acetylmuramoyl- N-terminal L- phosphodiesterase: kinase monophosphomannose transglutaminase mazG AAY42_RS04210 dehydrogenase: ppGpp metabolism L-lysyl-[protein] hydroxymethyltransferase: cytidylyltransferase: dihydrofolate RecO: pentapeptide- leucyl-L-lysine AAY42_RS14745 GlpK: glpK synthase: transketolase: domain-containing nucleotide pruA a (3R)-3- phosphoglycerate acyl-CoA AAY42_RS02590 kdsB reductase: type I DNA a stabilizedrecO RS04290 transferase: AAY42_RS14460 AAY42_RS06185 protein: pyrophosphohydrolase: hydroxydodecanoyl-[acp] lipid IV pppGpp kinase: dehydrogenase: AAY42_RS08600 topoisomerase: glu RecA filament- AAY42_RS07995 A sn-glycerol AAY42_RS08150 AAY42_RS08135 (P. putida) AAY42_RS12575 AAY42_RS15700 trans,octacis- a 7,8-dihydrofolate topA DNA complex bifunctional 3-phosphate D-glyceraldehyde CMP-Kdo decaprenylphospho- acetaldehyde gly dGMP a relaxed DNA UDP-3-O-[3- undecaprenyldiphospho- (2E)-dec-2-enoyl-CoA GDP F6P a protein with an RS00250 bifunctional (p)ppGpp β 3-phosphate 3-phospho-D-glycerate -D-mannose 6 γ hydroxymyristoyl] N- N-acetylmuramoyl-L- Amino Acid Biosynthesis synthetase/guanosine- N -( -glutamyl)- γ acetylglucosamine alanyl- -D-glutamyl-meso 3',5'-bis(diphosphate) 3'- L-lysine crosslink RS16850 deacetylase/3- -2,6-diaminopimeloyl- L-histidine biosynthesis pyrophosphohydrolase: 2,3-bisphosphoglycerate- L-lysine biosynthesis I L-arginine biosynthesis II (acetyl cycle) superpathway of L-serine L-phenylalanine L-alanine DHAP hydroxyacyl-ACP D-alanyl-D-alanine L-tryptophan biosynthesis AAY42_RS00605 independent (S)-3- an N-formyl-L- and glycine biosynthesis I biosynthesis I 37 (2R,3S)-3- hydrogen a [protein]- dehydratase: undecaprenyldiphospho- biosynthesis III phosphoglycerate cob(II)alamin a ferrocytochrome stearoyl-CoA an adenosine a tripeptide A(H2) 3',5'-ADP Rny PRPP hydroxydecanoyl-CoA methionylaminoacyl- DMAPP isopropylmalate peroxide L-tyrosine AAY42_RS04120 muramoylpentapeptide beta-N- 3-phospho- mutase: ATP b in tRNA dATP asp N-acetylglutamyl-phosphate chorismate tRNA 5 3-isopropylmalate polysaccharide 3'(2'),5'- acetylglucosaminyltransferase: N-acetyl-gamma- chorismate gln D-glycerate cys AAY42_RS07445 nucleoside triphosphate beta-hydroxyacyl- ATP aspartate kinase: bifunctional 3-deoxy-7- GTP ppGpp dehydrogenase: biosynthesis bisphosphate RS07005 murG glutamyl-phosphate phosphoglycerate : pyrophosphohydrolase: catalase/ ACP dehydratase: phosphoribosyltransferase: AAY42_RS10835 phosphoheptulonate C1 Compound Utilization peptide tRNA (adenosine(37)-N6) peptidase leuB tyrosine nucleotidase lipid II (meso reductase: dehydrogenase: serA AAY42_RS00510 cob(I)yrinic acid peroxidase AAY42_RS03510 AAY42_RS04080 3-oxodecanoyl-CoA and Assimilation -dimethylallyltransferase T: pepT mazG autokinase: diaminopimelate [+ 3 isozymes] anthranilate synthase: synthase/chorismate 2-phospho-D-glycerate a,c-diamide deformylase: 3-isopropylmalate HPI: katG CysQ: cysQ AAY42_RS14830 3-phosphooxypyruvate cysteine desulfurase: nucleoside- nucleotide AAY42_RS04995 a (2E)-dodec- containing) 1-(5-phospho- L-aspartyl-4-phosphate AAY42_RS07065 mutase type II: bifunctional (p)ppGpp AAY42_RS00305 MiaA: miaA dehydrogenase: RS15715 AAY42_RS12000 diphosphate acetyl-CoA C- formaldehyde oxidation adenosyltransferase: a [protein]- AMP 2-enoyl-[acp] β-D-ribosyl)-ATP n-acetylglutamate 3-phosphoserine/ AAY42_RS08180 synthetase/guanosine- pyrophosphohydrolase: leuB ala kinase: phosphopyruvate acyltransferase: VII (THF pathway) AAY42_RS00425 L-tyrosine synthase: acetylglutamate phosphohydroxythreonine 3',5'-bis(diphosphate) 3'- 6 a proteinogenic a dipeptide AAY42_RS08135 4-methyl-2- bifunctional aspartate- prephenate hydratase: eno N -(3-methylbut- A H O phosphate RS14705 anthranilate PRPP AAY42_RS00660 AAY42_RS05430 a L-methionylaminoacyl- a ferricytochrome oleoyl-CoA oxopentanoate 2 semialdehyde AAY42_RS02100 kinase: argB transaminase: serC pyrophosphohydrolase: formate 2-en-1-yl)- amino acid dAMP phosphoribosyl- glu N-acetyl-L-glutamate N-acetyl-L-glutamate 5-semialdehyde formaldehyde adenosylcobalamin tRNA b prephenate AAY42_RS00605 acetyl-CoA C- 5 adenosine 37 AMP dehydrogenase: O-phospho- triphosphate anthranilate dehydratase: acyltransferase: in tRNA cyclohydrolase/ AAY42_RS12790 L-serine phosphoenolpyruvate RS00965 AAY42_RS08195 AAY42_RS01730 a dodecanoyl-[acp] phosphoribosyl- phosphoribosyltransferase: trpD a 5,10- L-aspartate 4- N-acetylornithine 3-phenyl-2- GDP ATP diphosphatase semialdehyde gln aminotransferase: octanoyl-CoA methylenetetrahydrofolate a methylated RNase III mRNA a 2-oxo an N-acylated D-sedoheptulose (3R,5S)-3- oxopropanoate methanethiol O-acetyl-L- 2-oxoglutarate a uracil in DNA a ribonucleoside RS03310 HisIE: n-acetylglutamate N-(5-phosphoribosyl)-anthranilate pyruvate nucleobase processing carboxylate L-ornithine aliphatic-L- 1,7-bisphosphate a protein hydroxy-1- beta-ketoacyl- 4-hydroxy- AAY42_RS14840 bifunctional homoserine diphosphate AAY42_RS04030 carbamoyl-phosphate synthase: kinase: pyk acyl-CoA within DNA amino acid ribonucleoside- zinc-dependent pyrroline-5- ACP synthase tetrahydrodipicolinate 5,10-methylene- β synthase large AAY42_RS02100 phosphoribosylanthranilate ser dehydrogenase: carboxylate II: fabF 1-(5-phospho- - Macromolecule Modification tetrahydrofolate uracil-DNA diphosphate class II fructose- metalloprotease: pyrroline-5- RS11060 synthase: subunit: carB N-acetyl-L-ornithine isomerase: AAY42_RS07090 AAY42_RS15700 O-acetylhomoserine alpha-ketoglutarate- ornithine- laurate D-ribosyl)-AMP pyruvate dehydrogenase/ ribonuclease glycosylase: reductase: bisphosphate AAY42_RS15555 carboxylate AAY42_RS02440 serine phe aminocarboxypropyltransferase/ dependent -oxo-acid acylase: (2S,4S)-4- glutamine-hydrolyzing 1-(2-carboxyphenylamino)-1- (2E)-oct-2-enoyl-CoA 5,10-methylene- AAY42_RS03440 AAY42_RS11670 [+ 2 isozymes] reductase: a 3-oxotetradecanoyl- bifunctional hydroxymethyltransferase: tRNA-uridine 2-thiolation III: rnc transaminase: AAY42_RS14595 aldolase: fbaA long-chain fatty hydroxy-2,3,4,5- carbamoyl-phosphate deoxy-D-ribulose 5-phosphate queuosine tetrahydrofolate cysteine synthase: dioxygenase AlkB: AAY42_RS11675 proC Hormone Biosynthesis phosphoribosyl- AAY42_RS02590 and selenation (bacteria) a 2'- a peptide [acp] acid--CoA ligase: cyclohydrolase: AAY42_RS08280 AAY42_RS06775 rocD Hyp AMP tetrahydrodipicolinate synthase small indole-3-glycerol phosphate biosynthesis I (de novo) deoxyribonucleoside RS07905 AAY42_RS01745 RNase III an apyrimidinic uracil D-erythrose RS11485 3-oxoacyl- ethene biosynthesis III (microbes) cyclohydrolase/ 4-hydroxy- subunit: carA gly AAY42_RS16300 5'-diphosphate DHAP synthase TrpC: trpC cys an mRNA fragment processing site in DNA an aliphatic a carboxylate 4-phosphate RS11080 [acyl-carrier- tetrahydrodipicolinate preQ a nucleobase a proteinogenic L-glutamate-5- lauroyl-CoA phosphoribosyl- 0 (S)-3- a 5,10- acetate met formaldehyde succinate L-amino acid protein] reductase: dapB carbamoyl phosphate L-ornithine within DNA mRNA amino acid semialdehyde a siderophore- ATP diphosphatase (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate ammonia assimilation cycle III cysteine hydroxyoctanoyl-CoA methenyltetrahydrofolate reductase: (S)-2,3,4,5- bound Fe(III) HisIE: desulfurase: bifunctional fabG AAY42_RS04030 tetrahydrodipicolinate preQ tryptophan synthase: ammonium AAY42_RS00510 1 5,10-methylene- 4 a (3R)-3- 2503 an O - 6 D-sedoheptulose 7,8- RS11325 1-(5-phospho-β-D-ribosyl)- 2,3,4,5- trpB AAY42_RS07100 L-arginine adenine a [protein]- a D-aminoacyl- a [histone]-N - RS11345 hydroxytetradecanoyl- ornithine cysteine tRNA tetrahydrofolate methylthymine γ-L-glutamyl-(S)- gly [DNA] dihydroneopterin 5-[(5-phosphoribosylamino) tetrahydropyridine- in 23S rRNA L-cysteine a tRNA precursor [tRNA] acetyl-L-lysine 1-phosphate a protein RS11165 carbamoyltransferase: degradation I 2-oxoglutarate glu desulfurase: 3-oxooctanoyl-CoA dehydrogenase/ 2-aminobutanoate DNA polymerase [acp] stearate biosynthesis a siderophore- indole ser NADP-specific guanosine(34) in DNA ATP- 2',3'-cyclic methylideneamino]imidazole- 2,6-dicarboxylate N- (arginase pathway) AAY42_RS12000 5,10-methylene- bifunctional bound Fe(II) AAY42_RS14855 glutamate glutamine transglycosylase acetyl-CoA C- III subunit phosphate II (bacteria and plants) 4-carboxamide succinyltransferase: an [L-cysteine tetrahydrofolate 23S rRNA histone class II fructose- dependent zinc UDP-3-O-[3- synthetase III: Tgt: tgt methylated-DNA-- gamma/tau: 1-(5-phosphoribosyl)-5- AAY42_RS00295 arg dehydrogenase: gdhA acyltransferase: D-tyrosyl-tRNA(Tyr) deacetylase: glutathione bisphosphate metalloprotease tryptophan synthase: desulfurase]-S- a 7-aminomethyl-7- cyclohydrolase: (adenine(2503)-C(2) [protein]-cysteine S- ribonuclease Z: AAY42_RS05580 hydroxymyristoyl] N- glutamate synthase AAY42_RS17370 AAY42_RS05430 deacylase: synthase: FtsH: ftsH a palmitoyl-[acp] [(5- phosphoribosylamino) N-succinyl-2-amino- sulfanyl-L-cysteine 34 AAY42_RS16300 )-methyltransferase AAY42_RS05645 AAY42_RS10870 aldolase: fbaA RS14510 acetylglucosamine trpB AAY42_RS07100 deazaguanosine methyltransferase: [+ 2 isozymes] 7,8- RS07130 beta-ketoacyl- methylideneamino]imidazole-4- large subunit: gltB acetyl-CoA C- AAY42_RS08155 gshB a 2'- a peptide 6-ketopimelate 10 RlmN: rlmN dihydroneopterin MgtE deacetylase/3- Fe 2+ L-citrulline in tRNA an N - AAY42_RS11930 ACP synthase carboxamide isomerase: hisA L-leucine biosynthesis L-ornithine acyltransferase: deoxyribonucleoside hydroxyacyl-ACP N-succinyldiaminopimelate tRNA preQ1(34) S- formyltetrahydrofolate 2'-phosphate II: fabF trp imidazole glycerol AAY42_RS01730 a single-stranded acetate a [histone]-L-lysine 5'-monophosphate DHAP D-erythrose a 3-oxooctadecanoyl- phosphoribulosylformimino- a [TusA sulfur- adenosylmethionine a 2-methyladenine 2503 an uncharged ophthalmate dehydratase: aminotransferase: rocD argininosuccinate 3-methyl-2- ammonium phosphate gln formyltetrahydrofolate 5'-deoxyadenosine a [protein]-S- mature tRNA oligoribonucleotide a D-amino acid [acp] AICAR-phosphate ornithine- carrier protein]-S- ribosyltransferase- met a thymine in DNA tRNA AAY42_RS04120 N-succinyl-L,L-2,6- synthase: argG oxobutanoate synthase: hisF hisH hexanoyl-CoA deformylase: purU in 23S rRNA methyl-L-cysteine 2-isopropylmalate L-valine biosynthesis -oxo-acid sulfanyl-L-cysteine isomerase QueA: queA RS13255 beta-hydroxyacyl- 3-oxoacyl- diaminopimelate RS02040 superoxide imidazole synthase: transaminase: [+ 8 isozymes] 34 acyl-CoA ACP dehydratase: [acyl-carrier- L-arginino-succinate an epoxyqueuosine formate RS02920 glycerol AAY42_RS03145 rocD dehydrogenase: AAY42_RS03510 protein] pyruvate in tRNA a [protein]-L- a double 7,8- superoxide AAY42_RS15700 an N-terminal an L-phenylalanyl- + glycerophosphoserine N-acetyl-L- malonyl-CoA + phosphate argininosuccinate 2-isopropylmalate biosynthetic-type L-glutamate-5- a [TusD sulfur- tRNA H hydrogencarbonate carbamoyl H asp O-ureido-L- met dihydroneopterin reductase: arginyl-[protein] Phe β-isoaspartate stranded DNA a (2E)-tetradec- dismutase: synthase: semialdehyde [tRNA ] phosphate ornithine fabG lyase: argH synthase: acetolactate glu carrier protein]-S- epoxyqueuosine(34) (2E)-hexenoyl-CoA homoserine protein-L- DNA gyrase/ 2',3'-cyclic 2-enoyl-[acp] AAY42_RS13270 hisF hisH L,L-diaminopimelate n-acetylglutamate a (3R)-3- met (2S)-2- AAY42_RS02680 synthase: ilvB ilvN L-glutamate sulfanyl-L-cysteine reductase QueG: queG isoaspartate(D- topoisomerase phosphate RS09605 hydrogen carbonic anhydrase: glycerophosphodiester type III polyketide synthase: RS07930 hydroxyoctadecanoyl- arg isopropylmalate (S)-2-acetolactate gamma- a queuosine 34 leucyl/phenylalanyl- acetylornithine aspartate) O- IV subunit A: peroxide D-erythro-1- diaminopimelate AAY42_RS10920 phosphodiesterase: synthase: argininosuccinate AAY42_RS02100 RS12870 [acp] methionine semialdehyde in tRNA tRNA--protein carbamoyltransferase: methyltransferase: AAY42_RS04210 AICAR (imidazol-4- epimerase: 3-isopropylmalate ketol-acid AAY42_RS14745 AAY42_RS03500 synthase: argG bifunctional aminotransferase: dehydrogenase: transferase: carbonic anhydrase: AAY42_RS14855 AAY42_RS02545 [+ 2 isozymes] N-acetyl-L- 7,8- yl)-glycerol AAY42_RS02325 dehydratase: reductoisomerase: a [TusE sulfur (S)-3- a protein L-β- UDP-3-O-[3- AAY42_RS12150 pruA AAY42_RS14280 AAY42_RS13375 a negatively methionine dihydroneopterin L-cysteine biosynthesis I 34 carrier protein]-S isoaspartate a myristoyl-[acp] 3-phosphate leuD leuC ilvC a uridine in tRNA hydroxyhexanoyl-CoA supercoiled DNA 3'-phosphate hydroxymyristoyl] N- 4-(methylsulfanyl) meso-diaminopimelate -sulfanylcysteine sn-glycerol octoketide α-methyl ester hydroxyl radical bifunctional (2R)-2,3-dihydroxy- ser canavaninosuccinate RS15490 beta-ketoacyl- acetylglucosamine -2-oxobutanoate 2-isopropylmaleate glu L-phenylalanyl-L- 3-phosphate N-acetyl- RS06330 histidinol- 3-methylbutanoate Phe CO H O MscL ACP synthase deacetylase/3- ser tRNA 2- arginyl-[protein] a tRNA 2 2 L-citrulline phosphatase/ diaminopimelate 3-isopropylmalate II: fabF hydroxyacyl-ACP L-proline dihydroxy-acid serine acetyltransferase: thiouridine(34) imidazoleglycerol- decarboxylase: lysA dehydratase: L-tyrosine biosynthesis I 3-oxohexanoyl-CoA dehydratase: biosynthesis I dehydratase: ilvD AAY42_RS03985 synthase a 3-oxohexadecanoyl- phosphate leuD leuC AAY42_RS04120 (from L-glutamate) MnmA: mnmA an O 6 - β 5-fluorouridine 5'- a (1->4)- [acp] dehydratase lys O-acetyl-L-serine acetyl-CoA C- an N-terminal a [protein]- a D-tryptophanyl- -D-fructofuranose a supercoiled ethene (2R,3S)-3- 3-methyl-2-oxobutanoate chorismate an L-phenylalanyl- glycerophosphoglycerol a RNA-DNA hybrid monophosphate α RS14170 beta-hydroxyacyl- acyltransferase: Phe methylguanine Trp 1-phosphate duplex DNA gln -D-glucan RS08630 HisB: hisB glu L-lysyl-[protein] [tRNA ] L-cysteine [tRNA ] 3-oxoacyl- isopropylmalate bifunctional 3-deoxy-7- a 2-thiouridine 34 in DNA noncanonical UvrD-helicase 1,4-alpha- RS09370 ACP dehydratase: 3-(imidazol-4- O-acetylhomoserine AAY42_RS05430 [acyl-carrier- glutamate 5- 3-isopropylmalate branched-chain phosphoheptulonate in tRNA pyrimidine domain-containing amino acid glucan AAY42_RS03510 yl)-2-oxopropyl L-homoserine aminocarboxypropyltransferase/ acetyl-CoA C- class II fructose- protein] kinase: proB dehydrogenase: amino acid synthase/chorismate glycerophosphodiester nucleotidase, racemase: branching phosphate γ cysteine synthase: tRNA uridine-5- leucyl/phenylalanyl- methylated-DNA-- D-tyrosyl-tRNA(Tyr) ribonuclease HII: protein: a (2E)-octadec- biosynthesis -L-glutamyl aminotransferase: mutase type II: acyltransferase: phosphodiesterase: bisphosphate YjjG family: AAY42_RS08820 protein reductase: Polyprenyl Biosynthesis leuB AAY42_RS08280 carboxymethylaminomethyl(34) tRNA--protein [protein]-cysteine S- deacylase: AAY42_RS15650 AAY42_RS03200 2-enoyl-[acp] histidinol- 5-phosphate AAY42_RS17520 tRNA processing AAY42_RS01730 AAY42_RS14745 aldolase: fbaA AAY42_RS15980 fabG 3-isopropylmalate AAY42_RS08180 transferase: methyltransferase: [+ 2 isozymes] GlgB: glgB phosphate cysteine synthase synthesis GTPase MnmE: mnmE AAY42_RS08155 D-glutamine RS01590 RS16495 a (3R)-3- asp glutamate-5- prephenate AAY42_RS11930 a single a GlgE-glycogen transaminase: dehydrogenase: CysM: cysM tRNA uridine-5- butanoyl-CoA AAY42_RS14280 5-fluorouridine hydroxyhexadecanoyl- di-trans,poly-cis aspartate kinase: semialdehyde val a polycistronic a nucleoside 5'- stranded DNA RS03830 hisC leuB L-methionine biosynthesis III prephenate carboxymethylaminomethyl(34) glycerol sn-glycerol DHAP D-glyceraldehyde DNA [acp] -undecaprenyl AAY42_RS10835 dehydrogenase: tRNA precursor acyl-CoA monophosphate (2S)-2-isopropyl- dehydrogenase: cys synthesis enzyme MnmG: mnmG L-phenylalanyl- a [protein]-S- 3-phosphate D-tryptophan a tRNA Trp bifunctional phosphate biosynthesis L-histidinol [+ 3 isozymes] AAY42_RS14845 dehydrogenase: a tRNA Phe a guanine in DNA a stearoyl-[acp] L-aspartyl- 3-oxosuccinate AAY42_RS08185 L-lysyl-[protein] methyl-L-cysteine UDP-3-O-[3- (2E,6E)-farnesyl phosphate L-homoserine a 5-carboxymethylaminomethyl- AAY42_RS15700 IPP 4-phosphate L-glutamate-5- 3-(4- 34 hydroxymyristoyl] N- diphosphate 2-thiouridine in tRNA RS16500 bifunctional semialdehyde hydroxyphenyl) L-glutamate biosynthesis III crotonyl-CoA RS01320 acetylglucosamine L-threonine histidinol- aspartate- a tRNA precursor a tRNA precursor a mature peptidoglycan 34 a thiocarboxylated a glucosylated RS15050 pyruvate (n) a uridine sn-glycero-3- + deacetylase/3- isoprenyl biosynthesis O-succinyl-L- canavaninosuccinate ammonium NAD H O semialdehyde 4-methyl-2- 2 an L-amino acid leu phosphatase/ alanine with a 5' with a 5' (meso-DAP containing) in tRNA [SAMP] C- phosphoethanolamine GTP glycogenin hydroxyacyl-ACP transferase: dehydrogenase: oxopentanoate 2-oxoglutarate homoserine 1,4-alpha- stearate imidazoleglycerol- racemization a 5-aminomethyl-2- extension and extension and a terminal glycine dehydratase: AAY42_RS08440 AAY42_RS12790 L-homoserine O-acetyl-L- NADP-specific glutamate amino acid amino acid glucan phosphate (S)-1-pyrroline- branched-chain thiouridine 34 in tRNA a long 3' trailer short 3' extension adenylate/guanylate AAY42_RS04120 homoserine hydrogen sulfide dehydrogenase: gdhA (S)-3- lytic transglycosylase glycerophosphodiester nitrite racemase: racemase: long-chain fatty dehydratase L-aspartate 4- 5-carboxylate amino acid homoserine kinase: ribonuclease tRNA 2- cystathionine argininosuccinate cyclase domain- branching RS13880 di-trans,octa-cis ala tyr superpathway of L- glutamate synthase hydroxybutanoyl-CoA domain-containing phosphodiesterase: reductase: AAY42_RS08820 AAY42_RS08820 RS13920 beta-hydroxyacyl- acid--CoA ligase: HisB: hisB semialdehyde aminotransferase: AAY42_RS05475 P protein thiouridine(34) gamma-synthase: lyase: argH containing protein: protein -undecaprenyl pyrroline-5- alanine asparagine biosynthesis large subunit: gltB protein: AAY42_RS01870 AAY42_RS14745 nirD nirB YidD ACP dehydratase: AAY42_RS01745 AAY42_RS17520 O-phospho- O-acetylhomoserine component: synthase AAY42_RS15475 GlgB: glgB diphosphate bifunctional carboxylate racemase: alr endolytic transglycosylase AAY42_RS13630 a D-amino acid D-leucine AAY42_RS03510 histidinol L-homoserine aminocarboxypropyltransferase/ glu a 5-methylaminomethyl- a tRNA rnpA MnmA: mnmA cyclic-GMP a glycogen undecaprenyl- aspartate kinase/ reductase: [+ 2 isozymes] stearoyl-CoA asp 2-thiouridine 34 in tRNA a tRNA precursor MltG: mltG proC D-ala leu cysteine synthase: precursor with sn-glycerol L-canavanine fumarate a (2E)-hexadec- diphosphate histidinol homoserine threonine acetoacetyl-CoA ethanolamine nitrite AAY42_RS08280 a 5' extension with a short 34 2-enoyl-[acp] phosphatase: synthase: thrC a [SAMP] C- a 2-thiouridine 3-phosphate L-homocysteine succinate RS16025 dehydrogenase: dehydrogenase 3' extension a mature peptidoglycan GlcNAc-1,6-anhMurNAc- RS00820 AAY42_RS14390 pro acetyl-CoA C- (n) terminal glycine in tRNA hisD I: thrA asparagine asparagine ribonuclease (meso-DAP containing) L-Ala-γ-D-Glu-DAP-D-Ala RS09450 di-trans,octa-cis acyltransferase: bifunctional thr L-homocysteine synthetase B: synthase B: asnB a 5-methylaminomethyl- P protein -undecaprenyl histidinal 2-(S-geranyl) AAY42_RS01730 aspartate kinase/ AAY42_RS06155 asparagine component: UDP-N-acetyl- decaprenyl-diphospho-N- phosphate thiouridine 34 in tRNA β a [protein]- a DNA methyl a single- α histidinol homoserine methionine methionine asparagine synthetase B: rnpA acetyl-CoA C- fatty acid -oxidation I (generic) α an N-acylated- ampicillin a cytosine in DNA roseoflavin -amylose a palmitoyl-[acp] -D-glucosamine acetylmuramoyl-pentapeptide L-cysteine phosphotriester stranded RNA ATP Hyp dehydrogenase: dehydrogenase synthase: synthase: AAY42_RS06155 acyltransferase: D-amino acid bifunctional 1,4-alpha- RS11040 synthase B: asnB subclass B1 DNA cytosine RS13650 hisD I: thrA metH metH AAY42_RS05430 4-hydroxyproline riboflavin kinase/ glucan an uncharged a (3Z)-alk-3-enoyl-CoA undecaprenyldiphospho- metallo-beta- methyltransferase: adenylate/guanylate RS09030 a 5-methylaminomethyl- methylated-DNA-- polyribonucleotide epimerase: FAD synthetase: branching tRNA acetyl-CoA muramoylpentapeptide beta-N- lactamase: bla AAY42_RS10125 cyclase domain- met asn asn 2-(Se-phospho) [protein]-cysteine S- nucleotidyltransferase: D-aminoacylase: AAY42_RS04725 his L-homoserine acetylglucosaminyltransferase: (4S)-2-[(S)-[(2R)-2-amino-2- DNA (cytosine-5-)- containing protein: AAY42_RS10655 protein selenouridine 34 in tRNA methyltransferase: AAY42_RS07585 AAY42_RS07895 murG phenylacetamido](carboxylato) AAY42_RS15475 (4R)-4-hydroxy- roseoflavin GlgB: glgB palmitate AAY42_RS11930 methyltransferase: methyl]-5,5-dimethyl-1,3- dcm cyclic-AMP D-proline 5'-phosphate amylopectin RS16045 a (2E)-2-enoyl-CoA a 5-methylcytosine RS02270 long-chain fatty decaprenyl-pyrophosphoryl- a nucleoside a single- thiazolidine-4-carboxylate lipoprotein posttranslational a 2,3,4-saturated UDP a carboxylate in DNA RS11695 acid--CoA ligase: a 5-methylaminomethyl- (N-acetylglucosamine)-N- a [protein]-S- diphosphate stranded RNA a D-amino acid 34 modification fatty acid acyl-CoA [DNA] AAY42_RS01745 2-selenouridine long-chain fatty a 2,3,4-saturated (3R acetylmuramyl-(pentapeptide) methyl-L-cysteine in tRNA a [prolipoprotein]- acid--CoA ligase:dehydrogenase: )-3-hydroxyacyl-CoA palmitoyl-CoA AAY42_RS15700 L-cysteine AAY42_RS01745 a 2,3,4-saturated a 2,3,4-saturated (3S 10 a nascent peptidoglycan with (L- a DNA containing 2251 a (1->4)- RS14715 prolipoprotein an L-methionyl- an N - CTP guanosine a [protein]-α- RS14720 [2Fe-2S] iron-sulfur Cofactor, Carrier, and Vitamin Biosynthesis fatty acyl CoA )-3-hydroxyacyl-CoA γ a peptide with a histidinol α superpathway of biosynthesis I (bacteria) pyridoxal 5'-phosphate biosynthesis I Met alanyl- -D-glutamyl-meso-2,6- an apurinic/ his -D-glucan superpathway of tetrahydrofolate biosynthesis bis(guanylyl molybdopterin) bacillithiol biosynthesis diacylglyceryl acetyl-CoA C- [initiator tRNA ] formyltetrahydrofolate leader sequence nucleoside triphosphate in 23S rRNA L-glutamate RS12895 cluster biosynthesis diaminopimeloyl-D-alanine) tetrapeptide apyrimidinic site 23S rRNA protein-glutamate O- 1,4-alpha- cofactor sulfurylation transferase: lgt acyltransferase: pyrophosphohydrolase: histidinol 3-methyl-2- a 5,10- D-erythrose (guanosine(2251) methyltransferase L-histidine N(alpha) glucan (S)-malate UDP-N-acetyl- a [prolipoprotein]- AAY42_RS01730 mazG dehydrogenase: L-cysteine desulfurase oxobutanoate methylenetetrahydrofolate 4-phosphate -2'-O)- CheR: -methyltransferase: branching GTP cys α-D-glucosamine S-1,2-diacyl-sn- coenzyme A methionyl-tRNA LD-carboxypeptidase: endonuclease III: hisD a 2,3,4-saturatedacetyl-CoA C-a 2,3,4-saturated nucleotide methyltransferase AAY42_RS05270 egtD protein D-erythrose- glyceryl-L-cysteine formyltransferase: AAY42_RS06025 AAY42_RS04425 a [protein]-L- RS08860 cysteine 3-methyl-2-oxobutanoate fatty acyl CoAacyltransferase:3-oxoacyl-CoA pyrophosphohydrolase: RlmB: rlmB his GlgB: glgB RS16455 GTP 4-phosphate cysteine N-acetyl- AAY42_RS04880 2-O- glutamate-O 5 hercynine desulfurase: hydroxymethyltransferase: AAY42_RS05430 AAY42_RS08135 starch RS09020 cyclohydrolase dehydrogenase: desulfurase: alpha-D- lipoprotein methylguanosine 2251 -methyl-ester AAY42_RS00510 panB CMP gap AAY42_RS00510 glucosaminyl signal peptidase: an N-formyl- a nascent peptidoglycan with a 3'-terminal a 5'-phospho- in 23S rRNA cysteine I FolE: folE γ asp 4-phospho- L-malate AAY42_RS13675 a tetrahydrofolate (L-alanyl- -D-glutamyl-meso- D-ala unsaturated sugar a leader sequence a peptide GTP cysteine L-methionyl- [DNA] desulfurase: met 2,6-diaminopimelate) tripeptide 2-dehydropantoate D-erythronate desulfurase: synthase [initiator tRNA ] AAY42_RS12000 cyclohydrolase aspartate 1- an (S-diacyl- a lipoprotein RS01235 erythronate- AAY42_RS12000 BshA: bshA acetyl-CoA RS13980 I FolE: folE decarboxylase: sn-glyceryl) signal peptide an S-sulfanyl-[L- 7,8- 4-phosphate an [L-cysteine a [glycine-cleavage an [amino-group carrier RS09045 flavin biosynthesis I (bacteria and plants) AAY42_RS13955 NAD de novo biosynthesis (S)-malyl N- -L-cysteinyl- N-acetyl-D-glucosaminyl-N- a [DNA]-3'- (2E,6E)-farnesyl UTP a uracil 1498 a [protein]- cysteine desulfurase] dihydroneopterin dehydrogenase: desulfurase]-S- a sulfurated [sulfur carrier] SAM complex H protein] acetylmuramoyl-L-alanyl-D-glutamyl- protoheme protein]-C-terminal-γ- asn a protein II (from tryptophan) acetyl-α-D- [apolipoprotein] hydroxyl diphosphate nucleoside triphosphate in 16S rRNA L-histidine AAY42_RS04245 sulfanyl-L-cysteine N 6 -octanoyl-L-lysine (L-glutamyl)-L-glutamate 3'-triphosphate β-alanine Carbohydrate Degradation 6-carboxy-L-lysyl-D-alanine 16S rRNA histidine kinase: (R)-pantoate cysteine glucosaminide pyrophosphohydrolase: amino acid GTP (3R)-3-hydroxy-2-oxo- acetylglutamate (uracil(1498)-N(3))- trp bacillithiol mazG racemase: AAY42_RS00990 endopeptidase RS01450 4 phosphooxybutanoate desulfurase: a peptide exodeoxyribonuclease protoheme IX methyltransferase: RS15155 an S-sulfanyl-[cysteine biosynthesis D-galactose degradation I (Leloir pathway) LD-carboxypeptidase: kinase: argB [+ 5 isozymes] La: lon pantoate--beta- tryptophan 2,3- AAY42_RS00510 an N-acyl-(S- trehalose degradation II (cytosolic) lipoyl III: xth farnesyltransferase: nucleotide AAY42_RS05220 AAY42_RS08820 a [protein]- RS00950 desulfurase]-[disordered- 7,8- GTP 3-phosphoserine/ bis(guanylyl deacetylase AAY42_RS06025 an [amino-group carrier an N 3 - alanine ligase: dioxygenase: cysteine diacyl-sn-glyceryl) synthase: lipA cyoE pyrophosphohydrolase: N-phospho- form scaffold dihydroneopterin cyclohydrolase AAY42_RS13700 phosphohydroxythreonine molybdopterin) BshB1: bshB1 β-D-galactopyranose protein]-C-terminal- methyluracil 1498 D-asparagine a peptide AAY42_RS13960 N-Formyl-L- D-glyceraldehyde desulfurase: -L-cysteinyl- α,α-trehalose AAY42_RS08135 L-histidine protein] complex 3'-phosphate II: ribB pyruvate transaminase: serC cofactor a 2'- γ-(5-phospho-L- in 16S rRNA 2,5-diamino-6- kynurenine 3-phosphate AAY42_RS12000 (S)-malyl α-D- [lipoprotein] a [DNA]-3'- UMP 4-phosphooxy- aldose 1-epimerase: a [glycine-cleavage N-acetyl-D-glucosaminyl-N- deoxyribonucleoside glutamyl)-L-glutamate (5-phospho-D- a [bis(guanylyl glucosaminide 5'-deoxyadenosine 6 an unsulfurated hydroxyl ferroheme o L-threonine AAY42_RS16390 met complex H protein] N acetylmuramoyl-L-alanyl-D- D-ala 5'-monophosphate RS16445 (R)-pantothenate 1-deoxy-D-xylulose- molybdopterin) alpha,alpha- [sulfur carrier] RS05130 ribosylamino) bacillithiol galactose mutarotase: -[(R)-lipoyl]-L-lysine glutamyl-6-carboxy-L-lysine 5-phosphate 4-hydroxythreonine- cofactor [bis-MGD cofactor trehalase TreF: treF LptC a [cysteine desulfurase]- D-erythro-7,8- chorismate pyrimidin- type III biosynthesis AAY42_RS17105 S-sulfanyl-[disordered- dihydroneopterin 4(3H)-one synthase: 4-phosphate chaperone]-S- chaperone]- cysteine- 5-oxo-L-proline metabolism pantothenate L-kynurenine aminodeoxychorismate/ AAY42_RS11575 dehydrogenase sulfanyl-L-cysteine bis-MGD α-D-galactopyranose β-D-glucopyranose α-D-glucopyranose a [pyruvate dehydrogenase E2 D-glyceraldehyde D-sedoheptulose dTTP a double-stranded form scaffold dihydroneopterin bifunctional kinase: adding coenzyme A a nucleoside acetoacetyl-CoA an oligopeptide pyridoxamine an unfolded anthranilate synthase a [protein] with 6 protein] complex diaminohydroxyphosphoribosylaminopyrimidine PdxA: pdxA enzyme a sulfurated [sulfur carrier] SAM protein] N -octanoyl-L-lysine 3-phosphate 7-phosphate triphosphate oligonucleotide cysteine aldolase: folB AAY42_RS14990 3-amino-1- an N-terminal nucleoside triphosphate bifunctional 5'-phosphate protein component II: deaminase/5-amino-6-(5-phosphoribosylamino) 1-deoxy-D- BshC: bshC galactokinase: galK nucleotide 3-hydroxybutyryl- RS07735 L-glutamine a [protein] with pyrophosphohydrolase: oligopeptidase B: pyridoxamine RS14235 desulfurase: 6-(hydroxymethyl) AAY42_RS07070 (R)-4'- xylulose 5- hydroxyacetone pyrophosphohydrolase: oligoribonuclease/ CoA chaperonin uracil reductase RibD: ribD an N-terminal transketolase: mazG AAY42_RS04510 5'-phosphate RS02515 AAY42_RS00510 -7,8-dihydropterin 5-amino-6-(5- phosphopantothenate phosphate 1-phosphate sulfo-bis(guanylyl bacillithiol CoA pyrophosphatase: AAY42_RS08135 PAP phosphatase dehydrogenase: 4-amino-4- L-glutamate α α oxidase: pdxH GroEL: groL 3-hydroxy- glutaminyl-peptide -D-galactose 1-phosphate UDP- -D-glucose D-xylose AAY42_RS06180 AAY42_RS05850 nucleotide NrnA: cysteine 2-amino-4-hydroxy-6- deoxychorismate phospho-D- bifunctional molybdopterin) D-glucopyranose lipoyl synthase: lipA nucleoside triphosphate (S)-3- AAY42_RS02535 L-kynurenine pyridoxine 5'- cyclotransferase: degradation I transketolase: pyrophosphohydrolase: AAY42_RS00650 a peptide desulfurase: hydroxymethyldihydropteridine ribosylamino)uracil phosphopantothenoylcysteine cofactor pyrophosphohydrolase: hydroxybutanoyl- PLP a protein phosphate AAY42_RS02625 AAY42_RS06185 AAY42_RS08135 a nucleoside 5'- AAY42_RS12000 diphosphokinase: folK D-ribulose bifunctional decarboxylase/ kynureninase: D-xylose mazG CoA RS07860 an S-sulfanyl-[cysteine synthase: a nucleoside 5'- dTMP monophosphate RS10710 (7,8-dihydropterin- 5-phosphate diaminohydroxyphosphoribosylaminopyrimidine phosphopantothenate-- kynU a [protein] with xylose a [pyruvate dehydrogenase 3',5'-ADP 4'-phosphopantetheine desulfurase]-S- AAY42_RS08460 S-adenosyl-L- γ 5'-deoxyadenosine RS09360 6-yl)methyl 4-aminobenzoate deaminase/5-amino-6-(5-phosphoribosylamino) cysteine ligase CoaBC: coaBC -L-glutamyl isomerase: met E2 protein] N 6 -lipoyl-L-lysine an unsulfurated [sulfur carrier] D-ribose 5- D-xylulose monophosphate sulfanyl-[disordered- 3,4- methionine salvage II an N-terminal 5- glutathione D-glucopyranose 6-phosphate diphosphate uracil reductase RibD: ribD (R)-4'- 3-hydroxyanthranilate 5-phosphate xylA phosphate 5-phosphate form scaffold dihydroxy-2- 5-amino-6-(5- oxo-L-proline phosphopantothenoyl- pyridoxine D-xylulose protein] complex dihydropteroate butanone-4- phospho-D- 3-hydroxyanthranilate L-cysteine 5'-phosphate folate transformations III (E. coli) SAH synthase: folP phosphate ribitylamino)uracil 3,4-dioxygenase: an (R)-2- a [release factor]- α bifunctional pyridoxamine a 5-L-glutamyl- a ferrocytochrome palmitoyl-CoA a ribonucleoside a single -L-rhamnopyranose a dipeptide a DNA segment RS16450 RS13190 synthase: adenosylhomocysteinase: an amino acid halocarboxylate L-glutamine ile IPP phosphopantothenoylcysteine AAY42_RS13485 5'-phosphate [peptide] b triphosphate stranded DNA L-rhamnose RS07380 ribB adenosylcobalamin 2-amino-3- AAY42_RS14190 Pentose Phosphate Pathways 5 peptide chain branched-chain membrane isopentenyl- a [cysteine 7,8- decarboxylase/ oxidase: pdxH a tetrahydrofolate 5-oxo-L-proline D-xylulose mutarotase: recombinase 1-deoxy-L- salvage from cobalamin carboxymuconate- L-homocysteine release factor amino acid dipeptidase: diphosphate desulfurase]-(S- dihydropteroate phosphopantothenate-- 5-phosphate HAD family AAY42_RS06410 RecA: recA glycero-tetrulose 6-semialdehyde pentose phosphate trehalose degradation N(5)-glutamine AAY42_RS08850 Delta- sulfanyl) -[disordered- bifunctional ARP cysteine ligase CoaBC: coaBC PLP 5-oxoprolinase: gamma- hydrolase: DNA primase: aminotransferase: 2 4-phosphate cob(I)alamin methyltransferase: L-rhamnose a DNA segment isomerase: idi methionine methionine pathway (oxidative branch) I pxpA pxpB VI (periplasmic) AAY42_RS05545 AAY42_RS08090 AAY42_RS17520 a proteinogenic form scaffold folylpolyglutamate glutamyltransferase: ggt prmC mutarotase: rhaM (3S)-3-methyl-2- in reverse RS04270 4'-phosphopantetheine synthase: synthase: metH DMAPP RS07730 protein] complex synthase/ dihydrofolate D-glucopyranose α α a [release factor]-N 5 oxopentanoate amino acid 6,7-dimethyl-8- metH , -trehalose β-L-rhamnopyranose orientation RS12850 dihydrofolate reductase: 6-phosphate glu UDP-glucose-- -methyl-L-glutamine ribityllumazine cob(II)alamin pantetheine- quinolinate glucose-6- an α-(5-L- an (S)-2- ssDNA/pppN(pN) synthase: AAY42_RS08410 met UDP-glucose 4- a ferricytochrome a halide anion synthase: phosphate phosphate hexose-1-phosphate glutamyl)- a peptide palmitoleoyl-CoA hydroxycarboxylate hybrid AAY42_RS15725 n -1 AAY42_RS00685 cob(I)yrinic acid carboxylating dihydrofolate uridylyltransferase: epimerase GalE: galE alpha,alpha- b a [cysteine desulfurase]- adenylyltransferase: methionine dehydrogenase: amino acid 5 7,8-dihydrofolate a,c-diamide coaD nicotinate- reductase: AAY42_RS17110 trehalase TreF: treF [scaffold protein- serine adenosyltransferase: 6-phosphoAAY42_RS02000 RS06530 monoglutamate 6,7-dimethyl-8-(1- adenosyltransferase: nucleotide AAY42_RS08600 α α RS11270 (2Fe-2S)] complex 3'-dephospho- 6 37 -D-glucopyranose 1-phosphate UDP- -D-galactose a 7,8-dihydrofolate hydroxymethyltransferase: a 5-methyltetrahydrofolate AAY42_RS08285 D-glucono- N -L-threonylcarbamoyladenosine α undecaprenyl-diphospho-N an (S)-2- a 3,5,7,9,11,13,15- 4-(2'- D-ribityl)lumazine AAY42_RS00425 diphosphorylase: aldose 1-epimerase: UDP-N-acetyl- -D-glucosamine 2-oxobutanoate pyruvate a diphthine-[translation DNA with lesion β RS12885 CoA AAY42_RS02590 glycine cleavage system 1,5-lactone -modified tRNA biosynthesis -acetylmuramoyl-L-alanyl-γ- isobutanoate hepta-oxo- carboxyphenyl)- a uridine in tRNA a -lactam cob(II)alamin- nadC AAY42_RS16390 halocarboxylate riboflavin synthase: dephospho- aminomethyltransferase SAM phospho-sugar mutase: D-glutamyl-L-lysyl- D-alanine hexadecanoyl-[PKS-acp] elongation factor 2] 4-oxobutyryl-CoA excinuclease subclass B1 [corrinoid 6-phosphogluconolactonase: galactose mutarotase: aldo/keto 1,4-dihydroxy- tRNA CoA kinase: thymidylate GcvT: gcvT diphthine-- a [co-chaperone]- AAY42_RS12945 NaMN pgl thr AAY42_RS01810 undecaprenyldiphospho- reductase: dihydrouridine ABC subunit metallo-beta- a 7,8-dihydrofolate adenosyltranferase] synthase: AAY42_RS17105 HAD family biosynthetic-type ammonia ligase: 2-naphthoyl- [scaffold protein- AAY42_RS02485 [+ 2 isozymes] melibiose degradation α β-D-glucopyranose acetate--CoA synthase UvrB: uvrB lactamase: AAY42_RS08355 a (6S)-5- D-gluconate threonylcarbamoyl- -D-glucopyranose muramoylpentapeptide beta-N- hydrolase: acetolactate AAY42_RS14690 CoA synthase: RS07865 (2Fe-2S)] complex riboflavin nicotinate-nucleotide D-glucopyranose 6-phosphate ligase: acs AAY42_RS10825 DusB: dusB [+ 3 isozymes] bla RS15740 dihydrofolate coenzyme A formyltetrahydrofolate 6-phosphate AMP synthase: acetylglucosaminyltransferase: AAY42_RS05545 synthase: ilvB ilvN 9-hydroxy-3,5,7,11,13,15-[+ 4 isozymes] a diphthamide- AAY42_RS03895 RS08305 adenylyltransferase: melibiose 1,4-dihydroxy-2- a 5,6-dihydrouridine DNA without a substituted reductase: bifunctional 5-formyltetrahydrofolate NADP-dependent AAY42_RS00260 murG hexaoxohexadecanoyl- [translation β cob(I)alamin- AAY42_RS11600 thiamine diphosphate naphthoyl-CoA in tRNA lesion -amino acid AAY42_RS08410 methylenetetrahydrofolate cyclo-ligase: elongation factor 2] riboflavin kinase/ [corrinoid biosynthesis phosphogluconate threonylcarbamoyl- [PKS-acp] nicotinate adenine reductase [NAD(P)H]: metF AAY42_RS13680 ditrans,octacis-undecaprenyldiphospho- isobutanoyl-CoA an (S)-2- (S)-2-aceto-2- a [chaperone-ATP]- dihydrofolate FAD synthetase: adenosyltranferase] dehydrogenase: gndA AMP synthase: alpha-galactosidase: D-mannose degradation UDP diphosphate a halide anion dinucleotide II (Bacillus) N-acetyl-(N-acetylglucosaminyl)muramoyl- AMP hydroxycarboxylate hydroxybutanoate [co-chaperone]- reductase: AAY42_RS10655 cob(I)yrinic acid a 5,10- a 5,10- D-ribulose AAY42_RS03205 AAY42_RS13220 biotin biosynthesis from HMP-PP (L-threonylcarbamoyl) L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine [scaffold protein- AAY42_RS08600 a,c-diamide methylenetetrahydrofolate methenyltetrahydrofolate 5-phosphate D-mannopyranose FMN 8-amino-7-oxononanoate I molybdopterin biosynthesis bifunctional adenylate RS06395 (2Fe-2S)] complex adenosyltransferase: D-galactopyranose D-glucopyranose 6-phosphate a tetrahydrofolate 5,10-methylene-bifunctional tRNA (adenosine(37)-N6)- class I mannose- bifunctional AAY42_RS00425 (8S)-8-amino-7- tetrahydrofolate5,10-methylene- UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N-acetylmuramoyl-L- lysine within a long-chain 4-fumaryl- a cytidine 1402 a 2'- UDP NAD + thiamine threonylcarbamoyltransferase 6-phosphate NADPH H + a holo [BryP acyl- acetaldehyde arsenate adenosylcob(III) oxononanoate cys alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine gcv protein H an octanoyl-[acp] fatty acyl-CoA riboflavin kinase/ adenosylmethionine- dehydrogenase/tetrahydrofolate phosphate complex ATPase subunit isomerase: acetoacetate in 16S rRNA carrier protein] deoxyribonucleoside ribonucleoside- dipyrromethane alamin-[corrinoid ATP 16S rRNA deoxynucleoside aldehyde arsenate FAD synthetase: -8-amino-7- 5,10-methylene-dehydrogenase/ type 1 TsaE: tsaE AAY42_RS06820 undecaprenyldiphospho- ACP S- diphosphate a [chaperone- cofactor biosynthesis adenosyltranferase] cysteine GTP thiamine- (cytidine(1402)-2'-O) dehydrogenase reductase an [2Fe-2S] AAY42_RS10655 oxononanoate tetrahydrofolate5,10-methylene- F6P muramoylpentapeptide beta-N- acyl-CoA kinase: reductase: ADP]-[disordered- cob(I)yrinic acid desulfurase: phosphate [+ 2 isozymes] lipoyl(octanoyl) fumarylacetoacetase: -methyltransferase: malonyltransferase: (NADP(+)): (glutaredoxin) RS02915 cluster protein an apo-[hydroxymethylbilane transaminase: bioA cyclohydrolase:tetrahydrofolate an N 6 -L- acetylglucosaminyltransferase: reductase: AAY42_RS08300 AAY42_RS11670 form scaffold FAD a,c-diamide (7R,8S)- AAY42_RS00510 kinase: thiL transferase fahA rsmI fabD a 2'- AAY42_RS07670 : arsC GTP 3',8- AAY42_RS16300cyclohydrolase: 37 a 2'-O- a malonyl- AAY42_RS11675 protein] complex synthase]-L-cysteine adenosyltransferase: threonylcarbamoyladenine murG LipB: lipB AAY42_RS04235 diaminononanoate cysteine thiamine 1402 deoxyribonucleoside acetate arsenite cyclase AAY42_RS16300 in tRNA methylcytidine [BryP acyl- dUDP AAY42_RS00425 desulfurase: a carboxy- diphosphate 5'-monophosphate dethiobiotin MoaA: an N 10 - in 16S rRNA carrier protein] a [hydroxymethylbilane AAY42_RS12000 adenylated Inorganic Nutrient Metabolism ditrans,octacis-undecaprenyldiphospho-N- UDP a [glycine-cleavage a long-chain synthase: bioD moaA TCA cycle TCA cycle I (prokaryotic) acetoacetate fumarate synthase] ES intermediate adenosylcobalamin an [L-cysteine [small subunit of formyltetrahydrofolate acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- acyl-carrier protein complex H protein] an [Fe-S cluster 2 (8S)-3',8-cyclo-7,8- fatty aldehyde alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine N 6 -octanoyl-L-lysine FtsY biosynthesis hydroxymethylbilane dethiobiotin desulfurase]-S- molybdopterin dihydroguanosine selenate reduction acetyl-CoA polyphosphate metabolism chaperone]-ATP synthase: hemC sulfanyl-L-cysteine synthase] 5'-triphosphate thiosulfate oxidation III (multienzyme complex) biotin cyclic pyranopterin an (S)-2- 1402 a [protein]-L- L-malic dCDP D-ribose 5- molybdenum a [hydroxymethylbilane menaquinol-10 biosynthesis folate polyglutamylation selenate dethiobiotin a sulfurated O-succinyl-L- stachyose a cytidine a holo [BryU acyl- synthase monophosphate oxaloacetate long chain SAM methanethiol ω phosphate cofactor biosynthesis synthase] ES intermediate sulfate a [SoxY protein]-L-cysteine [sulfur carrier] homoserine halocarboxylate in 16S rRNA proline ( = 180) semialdehyde ribonucleoside- 3 menaquinol-11 biosynthesis BioB: bioB synthase polyphosphate 16S rRNA carrier protein] peptidylprolyl aldehyde ribose 5- all-trans- citrate synthase: adenylyltransferase diphosphate hydroxymethylbilane 1,4-dihydroxy- a thiocarboxylated MoaC: moaC a tetrahydrofolate (cytosine(1402)-N(4) ACP S- isomerase: dehydrogenase phosphate RS11160 cytidylyl molybdenum molybdopterin all-trans- 9-mercaptodethiobiotin decaprenyl AAY42_RS16220 alpha- molybdate synthase: hemC [small subunit of cyclic adenosine 5'-subunit CysD: cysD cystathionine HAD family malonyltransferase: AAY42_RS17685 reductase: isomerase undecaprenyl 1,4-dihydroxy- diphosphate 2-naphthoate biotin galactosidase: )-methyltransferase (NADP(+)): cofactor sulfurylation molybdopterin pyranopterin hydrolase: fabD AAY42_RS11670 a [hydroxymethylbilane phosphoselenate polyphosphate exopolyphosphatase: synthase gamma-synthase: 4 RsmH: rsmH [+ 5 isozymes] AAY42_RS07670 B: rpiB diphosphate 2-naphthoate biotin serine bifunctional AAY42_RS05545 AAY42_RS13220 an N - a malonyl- AAY42_RS11675 cytidylyl molybdenum synthase] phosphate a [SoxY protein]-S- kinase 1: ppk1 AAY42_RS05625 AAY42_RS13630 a [protein]-L- D-ribulose synthase] ES intermediate synthase BioB: bioB 1402 (S)-malate 4 hydroxymethyltransferase: folylpolyglutamate malate dehydrogenase: mdh sulfosulfanyl-L-cysteine methylcytidine [BryU acyl- proline (ω = 0) CDP 5-phosphate cofactor (trioxo) molybdopterin BioB: bioB hydroxymethylbilane AAY42_RS02590 synthase/ an N 10 - α-D- in 16S rRNA carrier protein] menaquinol-7 biosynthesis a (2R)-2- raffinose molybdate adenine synthase: hemC dihydrofolate cytochrome c: biotin 5'-deoxyadenosine an unsulfurated succinate a halide anion galactopyranose RS08970 an [MCD cofactor biotin DMKH2-10 formyltetrahydrofolate (S)-malate citrate selenite long chain met met hydroxy fatty acid dinucleotide a 5,10- synthase: AAY42_RS09115 [sulfur carrier] chaperone]-MCD a holo-[hydroxymethylbilane DMKH2-11 all-trans- bifunctional polyphosphate bifunctional molybdopterin methylenetetrahydrofolate AAY42_RS15725 synthase] heptaprenyl 1,4-dihydroxy- folylpolyglutamate cytochrome c: cysteine molybdopterin demethylmenaquinone bifunctional diphosphate 2-naphthoate bifunctional synthase/ AAY42_RS13555 desulfurase: molybdotransferase an (R)-2- 527 N-acetyl-D- an organic demethylmenaquinone methyltransferase/2- folylpolyglutamate a [SoxY protein]-S- a [SoxY protein]-S a proteinogenic leukotriene-C4 lipid IV (E. coli) CMP-Kdo melibionate a holo [PedD acyl- a guanine D-glycerate nicotinate adenine AAY42_RS00510 MoeA: a tetrahydrofolate dihydrofolate A halocarboxylate glucosamine hydroperoxide methyltransferase/2- glutathione methoxy-6-polyprenyl- synthase/ aconitate hydratase: amino acid carrier protein] in 16S rRNA dinucleotide RS00120 AAY42_RS03825 synthase: selenodiglutathione disulfanyl-L-cysteine -sulfanyl-L-cysteine 16S rRNA N-acetylglucosamine thiol cysteine methoxy-6-polyprenyl- biosynthesis 1,4-benzoquinol dihydrofolate AAY42_RS06590 D-glycerate NAD(+) hydroxymethylpyrimidine AAY42_RS15725 class II fumarate ACP S- (guanine(527)-N(7) kinase: peroxidase: desulfurase: 1,4-benzoquinol methylase UbiE: ubiE thioredoxin synthase: 3-deoxy-D-manno- HAD family alpha- dehydrogenase: synthase: MoO - salvage 10 malonyltransferase: 2 hydratase: fumC )-methyltransferase tpx AAY42_RS12000 demethylmenaquinol-7 pathway an N - octulosonic acid hydrolase: galactosidase: AAY42_RS05190 AAY42_RS15840 nadE molybdopterin methylase UbiE: ubiE cys glu tetrahydrofolate salvage from AAY42_RS15725 gamma- fabD N-acetyl-D- 4-amino-2-methyl-5- menaquinol-10 formyltetrahydrofolate fumarate cis-aconitate 7 RsmG: rsmG [+ 2 isozymes] a [cytidylyl molybdenum 5,10-methenyltetrahydrofolate transferase: AAY42_RS05545 AAY42_RS13220 a malonyl- an N - + cofactor bifunctional a 5,10- glutamyltransferase: ggt glucosamine hydroxypyruvate NAD cofactor chaperone]- pyrimidinemethanol menaquinol-11 an oxidized glutathioselenol AAY42_RS09425 [PedD acyl- methylguanine 527 an alcohol bifunctional demethylmenaquinone methylenetetrahydrofolate lipoate biosynthesis aconitate hydratase: sulfur urea cycle 6-phosphate SecY cytidylyl molybdenum a 5,10-methenyltetrahydrofolate thioredoxin succinate dehydrogenase/ α-D- carrier protein] in 16S rRNA hydroxymethylpyrimidine methyltransferase/2- and incorporation I AAY42_RS06590 reduction II (via cofactor (sulfo-dioxo) a [SoxY protein]-S-(2- α γ α a (2R)-2- D-gluconate kinase/ bifunctional 5,10- fumarate reductase polysulfide) an -( -L-glutamyl) CMP -Kdo-(2->6)- a halide anion galactopyranose methoxy-6-polyprenyl- thiamine diphosphate sulfodisulfanyl)-L-cysteine leukotriene-D4 hydroxy fatty acid demethylmenaquinol- phosphomethylpyrimidine γ methylene-tetrahydrofolate iron-sulfur subunit: arg ammonium -L-amino acid lipid IV (E. coli) 1,4-benzoquinol -L-glutamyl- an octanoyl-[acp] 0 A dehydrogenase/5,10- thioredoxin- biosynthesis I (E. coli) AAY42_RS12140 S 8 biosynthesis I kinase: AAY42_RS13280 methylase UbiE: ubiE L-cysteine hydrogen selenide menaquinol-9 biosynthesis methylene-tetrahydrofolate disulfide lipoyl(octanoyl) carbamoyl- all-trans- HMP-P glutathione p-nitrophenyl-α-D- 46 cyclohydrolase: reductase: HMP-PP transferase phosphate synthase a proteinogenic raffinose a holo [PedN acyl- a guanine RS08785 1,4-dihydroxy- octaprenyl menaquinol-7 synthase: argininosuccinate glutathione hypoglycin A glutathione galactopyranoside chloroacetaldehyde D-glycerate an aldehyde ethanol bifunctional AAY42_RS16300 trxB a [lipoyl-carrier LipB:protein] lipB succinate D-threo-isocitrate a polysulfide large subunit: carB amino acid carrier protein] in tRNA 2-naphthoate diphosphate demethylmenaquinol-9 gshB NADP-dependent lyase: argH tRNA aldehyde aldehyde hydroxymethylpyrimidine an N 10 -formyltetrahydrofolate N 6 -octanoyl-L-lysine D-glycerate catalase/ bifunctional menaquinol-8 biosynthesis menaquinol-6 biosynthesis isocitrate dehydrogenase: glutamine- ACP S- (guanosine(46)-N7) dehydrogenase dehydrogenase kinase/ thiamine ADP-forming polysulfide alpha- alpha- dehydrogenase: peroxidase 1,4-dihydroxy- demethylmenaquinone glutathione lipoyl AAY42_RS02280 hydrolyzing malonyltransferase: -methyltransferase (NADP(+)): (NADP(+)): phosphomethylpyrimidine phosphoribosylglycinamide a reduced phosphate succinate--CoA ligase reductase galactosidase: galactosidase: AAY42_RS15840 HPI: katG 2-naphthoate methyltransferase/2- synthase: lipA L-arginino-succinate L-ornithine carbamoyl- gamma- gamma- fabD TrmB: trmB AAY42_RS07670 AAY42_RS07670 thioredoxin demethylmenaquinol-8 thiamine- demethylmenaquinol-6 NADP-dependent NrfD: nrfD AAY42_RS13220 AAY42_RS13220 a malonyl[PedN an N 7 - octaprenyltransferase: kinase: AAY42_RS13280 NADP formyltransferase: purN subunit beta: sucC phosphate synthase glutamyltransferase: ggt glutamyltransferase: ggt hydroxypyruvate acetaldehyde methoxy-6-polyprenyl- a [lipoyl-carrier isocitrate dehydrogenase: 46 2-chloroacetate a carboxylate biosynthesis bifunctional phosphate bifunctional acyl-carrier methylguanine menA 1,4-benzoquinol protein]-N 6 -[(R)- succinate--CoA ligase a polysulfide small subunit: carA HMP-PP a tetrahydrofolate demethylmenaquinone kinase: thiL demethylmenaquinone AAY42_RS01935 α-D- protein] in tRNA methylase UbiE: ubiE dihydrolipoyl]-L-lysine subunit alpha: sucD D-galactopyranose sucrose + methyltransferase/2- methyltransferase/2- an α-(γ-L-glutamyl) 4-nitrophenol galactopyranose NAD thiamine ornithine carbamoyl phosphate L-cysteinylglycine hypoglycin B L-cysteinylglycine demethylmenaquinol-8 menaquinol-9 methoxy-6-polyprenyl- methoxy-6-polyprenyl- NAD kinase: diphosphate succinyl-CoA 2-oxoglutarate carbamoyltransferase: -L-amino acid 1,4-benzoquinol 1,4-benzoquinol argininosuccinate AAY42_RS08450 AAY42_RS14855 methylase UbiE: ubiE methylase UbiE: ubiE synthase: argG + sulfate activation NADP 6 an α-D- 1518 (9Z,15Z)-12,13- 37 menaquinol-8 menaquinol-6 L-citrulline + a [histone]-N - D-threo-7,8- adenine / guanine for sulfonation NAD epoxy-octadeca- homogentisate CAIR MeOH acetyl-L-lysine galactoside dihydroneopterin adenine 1519 in 16S rRNA in tRNA Phe met 16S rRNA 9,15-dienoate tRNA homogentisate 5-(carboxyamino) catalase/ 2-oxoglutarate sulfate (adenine(1518)-N(6)/ (guanosine(37)-N1) methionine imidazole NAD-dependent alpha- epoxide hydrolase: 1,2-dioxygenase: peroxidase dehydrogenase sulfate dihydroneopterin adenine(1519)-N(6))- -methyltransferase aminotransferase: ribonucleotide deacylase: galactosidase: AAY42_RS13075 AAY42_RS09240 HPI: katG E1 component: adenylyltransferase aldolase: folB dimethyltransferase TrmD: trmD AAY42_RS12150 mutase: purE AAY42_RS02125 AAY42_RS13220 (9Z,15Z)-12,13- an N 1 - 4-(methylsulfanyl) 4-maleyl- AAY42_RS09400 subunit CysD: cysD Amino Acid Degradation RsmA: rsmA formaldehyde APS N 6 -dimethyladenine 1518 dihydroxyoctadeca- methylguanine 37 -2-oxobutanoate acetoacetate AIR α-D- a non /N 6 -dimethyladenine 1519 9,15-dienoate in tRNA Phe 2''-O-acetyl- 6-(hydroxymethyl) glycolaldehyde adenylyl-sulfate L-histidine degradation I nicotinamide galactopyranose galactosylated glycine cleavage L-methionine degradation ADP-ribose a [histone]-L-lysine -7,8-dihydropterin in 16S rRNA kinase: cysC galactose acceptor a [glycine-cleavage I (to L-homocysteine) his PAPS complex H protein] N 6 histidine a [protein]-N 6 - (9Z,12Z)-15,16- 37 -[(R)-lipoyl]-L-lysine glycine cleavage system met + RNase R degradation a guanine sn-glycerol (R)-2,3-dihydroxy- phosphoenol NAD maltohexaose 1-aminocyclopropane- epoxyoctadeca- propanoate ammonia- aminomethyltransferase methionine acetyl-L-lysine substrate RNA 1-carboxylate in tRNA 3-phosphate 3-methylpentanoate pyruvate aminomethyl- 9,12-dienoate tRNA lyase: hutH adenosyltransferase: 1-aminocyclopropane- dihydroxy-acid transferring GcvT: gcvT L-glyceraldehyde acetate kinase: pyruvate urocanate AAY42_RS08285 epoxide hydrolase: (guanosine(37)-N1) dehydratase: glycine [+ 2 isozymes] NAD-dependent alpha-glucosidase: 1-carboxylate 3-phosphate AAY42_RS00930 ribonuclease AAY42_RS13075 -methyltransferase kinase: pyk dehydrogenase: SAM deacylase: deaminase/D-cysteine reductase: mgrA ilvD urocanate R: rnr AAY42_RS05795 TrmD: trmD desulfhydrase: (9Z,12Z)-15,16- an N 1 - L-glyceraldehyde (3S)-3-methyl-2- propanoyl hydratase: gcvP AAY42_RS02125 pyruvate a [glycine-cleavage AAY42_RS15455 dihydroxyoctadeca- methylguanine 37 3-phosphate oxopentanoate phosphate AAY42_RS09920 [+ 4 isozymes]a [glycine-cleavage complex H protein] N 6 - 2-oxobutanoate 9,12-dienoate in tRNA 4-imidazolone- complex H protein] N 6 2''-O-acetyl- a nucleoside 5'- D-glucopyranose maltopentaose aminomethyldihydrolipoyl- nicotinamide a [protein]-L-lysine a diribonucleotide 5-propanoate -dihydrolipoyl-L-lysine ADP-ribose monophosphate L-lysine SAH imidazolonepropionase: hutI (12Z,15Z)-9,10- a [protein]- adenosylhomocysteinase: 3-methyl-2- 5,10-methylene- a uracil 1939 (2S)- (3Z)-hex- an aryl sulfate a phenol maltoheptaose maltopentaose citrate L-tyrosine N-formimino- aminomethyl- AAY42_RS14190 oxobutanoate tetrahydromethanopterin epoxyoctadeca- in 23S rRNA ethylmalonyl-CoA 3-en-1-ol 12,15-dienoate 23S rRNA phosphate L-glutamate transferring aconitate methylmalonyl- protein-tyrosine- glycine 3-methyl-2-oxobutanoate epoxide hydrolase: (uracil(1939)-C(5)) hydratase: formimidoylglutamase: L-homocysteine aryl-sulfate alpha-glucosidase: alpha-glucosidase: CoA phosphatase: dehydrogenase: hydroxymethyltransferase: AAY42_RS13075 -methyltransferase AAY42_RS06590 AAY42_RS15240 : AAY42_RS05795 AAY42_RS05795 epimerase: mce AAY42_RS10765 gcvP panB (12Z,15Z)-9,10- RlmD: rlmD (2R)- (3Z)-hex-3- formimidoylglutamase: AAY42_RS15755 a 5-methyluracil 1939 D-threo-isocitrate a [protein]- hutG [+ 2 isozymes] dihydroxyoctadeca- in 23S rRNA ethylmalonyl-CoA L-tyrosine en-1-yl acetate 12,15-dienoate D-glucopyranose maltohexaose D-glucopyranose maltotetraose glu L-serine degradation L-glutamine 2-dehydropantoate THMPT an aryl sulfate a phenol degradation I

L-threonine L-glutamate ser degradation II gln 5-amino-4- an [amino-group carrier protein]- a uridine 55 (2R,3S)-3- α-D-glucosamine degradation II L-serine PRPP F6P γ maltotriose vernolate chorismate D-glucopyranose imidazole imidazolecarboxyamide C-terminal- -(L-glutamate 5- in tRNA isopropylmalate 6-phosphate ammonia-lyase: glu glycerol semialdehyde-2-yl)-L-glutamateN-acetyl-gamma- tRNA 3-isopropylmalate isochorismate glucosamine- xylose thr 2-aminoprop-AAY42_RS02730 phosphate epoxide hydrolase: 6-phosphate isomerase: adenine fructose-6- glutamyl-phosphate alpha-glucosidase: pseudouridine(55) dehydratase: synthase: 2-enoate synthase: AAY42_RS13075 deaminase: xylA phosphoribosyltransferase: phosphate reductase: AAY42_RS05795 synthase TruB: truB leuD leuC AAY42_RS04700 hisF hisH (9Z)-12,13- 55 nagB an [amino-group carrierAAY42_RS14830 protein]- a pseudouridine (2S)-2- keto-D-fructose AAY42_RS17330 aldolase: fsa dihydroxyoctadeca- isochorismate L-2-amino-3- asp [+ 8 isozymes] C-terminal-γ-(5-phospho- in tRNA isopropylmalate F6P oxobutanoate glu L-glutamyl)-L-glutamate 9-enoate aspartate D-glyceraldehyde D-glucopyranose maltose 2-iminopropanoate AICAR dihydroxyacetone glycine C- ammonia- 3-phosphate acetyltransferase: kbl lyase: aspA L-alanine degradation IV gly fumarate a generic DNA combined with a pseudouridine 1915 a (1->4)- (1R,6R)-6-hydroxy-2- aldehydo-D- exogenous DNA to form α-D-glucan succinylcyclohexa-2,4- oxaloacetate D-glucopyranose an aryl sulfate ser galacturonate pyruvate L-glutamine polynucleotide substrate in 23S rRNA ala diene-1-carboxylate L-asparagine degradation II a recombinational junctionHolliday junction 23S rRNA glucose 1- sulfatase: glucuronate alanine o-succinylbenzoate citrate synthase: L-serine degradation I resolvase RuvX: ruvX (pseudouridine(1915)- dehydrogenase: AAY42_RS14890 isomerase: dehydrogenase: S1/P1 nuclease: N(3))-methyltransferase alpha-glucosidase: synthase: AAY42_RS16220 AAY42_RS07695 ammonia-lyase: crossover junction [+ 13 isozymes] uxaC gln AAY42_RS16740 AAY42_RS06780 RlmH: rlmH AAY42_RS05795 AAY42_RS04660 AAY42_RS02730 endodeoxyribonuclease 3 1,2-dihydroxypropane- D-glucono- asn glutamate an N - a phenol D-tagaturonate [+ 2 isozymes] 1915 2-succinylbenzoate 1,5-lactone pyruvate synthase large resolution of recombinationalRuvC: ruvC methylpseudouridine 1,2,3-tricarboxylate asparaginase: pyruvate a (1->4)- AAY42_RS09380 subunit: gltB junction formation in 23S rRNA D-glucopyranose glu a 5'-phosphomononucleotide a 5'-phosphooligonucleotide α-D-glucan asp of two intact strands

2-amino-6-[1-hydroxyethyl]- D-arabinofuranose D-ribulose cytidine glycyl-glycine glutathione uroporphyrinogen-III 4-nitrocatecholsulfate D-glucopyranose a ribonucleoside 7-methyl-7,8-dihydropterin D-cysteine 5-phosphate 5-phosphate 5'-monophosphate 2-amino-4-hydroxy-6- uroporphyrinogen-III C- 3-deoxy-8- glucose 1- ribulose-phosphate uridine inosine 5'- Nucleoside and Nucleotide Degradation 1-aminocyclopropane-1- sulfatase: 5'/3'- hydroxymethyldihydropteridine methyltransferase: cobA phosphooctulonate dehydrogenase: 3-epimerase: kinase: udk phosphate guanosine carboxylate deaminase/D- AAY42_RS14890 nucleotidase nucleotides gamma- diphosphokinase: folK uroporphyrinogen-III C- synthase: kdsA [+ 13 isozymes] AAY42_RS07695 AAY42_RS07620 degradation cysteine desulfhydrase: SurE: surE CMP degradation III glutamyltransferase: ggt [1-(2-amino-7-methyl-4-oxo- methyltransferase: cobA D-glucono- D-xylulose AAY42_RS15455 KDO-8P 4-nitrocatechol 7,8-dihydro-3H-pteridin- precorrin-2 1,5-lactone 5-phosphate a ribonucleoside IMP pyruvate GMP 6-yl)]ethyl diphosphate IMP γ-L-glutamyl- 5'/3'- L-cysteinylglycine dehydrogenase: glycylglycine guaB nucleotidase SurE: surE XMP purine ribonucleosides degradation guanosine 3-(4- 2604 UDP-N-acetyl-α-D-muramoyl- 38-40 a uridine β uridine D-alanyl-D-alanine a uridine in tRNA hydroxyphenyl) uroporphyrinogen-I D-galactopyranose L-fuconate GDP- -L-fucose methylglyoxal 5'/3'- L-alanyl-γ-D-glutamyl-L-lysine in 23S rRNA purine-nucleoside RluA family pseudouridine pyruvate 23S rRNA L-fuconate GDP-L-fucose uridine nucleotidase adenosine uroporphyrinogen galactose oxidase: phosphorylase: synthase: AAY42_RS07145 4-hydroxyphenylpyruvate pseudouridine(2604) dehydratase: synthase: glyoxalase: kinase: udk SurE: surE UDP-N-acetylmuramoyl- decarboxylase: hemE AAY42_RS11235 AAY42_RS14960 tRNA pseudouridine(38- dioxygenase: hppD synthase RluF: rluF AAY42_RS06445 AAY42_RS05045 AAY42_RS18335 tripeptide--D-alanyl-D- UMP 40) synthase TruA: truA 2604 2-dehydro-3- GDP-4-dehydro- xanthosine alanine ligase: murF a pseudouridine D-galacto- 38-40 coproporphyrinogen I α-D-rhamnose (R)-lactate guanine a pseudouridine in tRNA homogentisate in 23S rRNA hexodialdose deoxy-L-fuconate purine-nucleoside UDP-N-acetyl-α-D-muramoyl-L-alanyl- phosphorylase: xanthosine adenosine inosine guanosine γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine AAY42_RS14960

2,5-diamino-6-(5- 10 β-D-glucopyranose 2'-deoxycytidine xanthine xanthine 4a-hydroxy-N - 3-phenyl-2- (S)-2-aceto-2- maltose purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside phospho-D-ribitylamino) myo-inositol (R)-lactate formyltetrahydrofolate oxopropanoate 1-phosphate hydroxybutanoate deoxynucleoside phosphorylase: phosphorylase: phosphorylase: phosphorylase: pyrimidin-4(3H)-one bifunctional 4a-hydroxytetrahydrobiopterin beta- ketol-acid kinase: D-2-hydroxyacid AAY42_RS14960 4-hydroxyphenylpyruvate alpha-glucosidase: inositol oxygenase: AAY42_RS14960 AAY42_RS14960 AAY42_RS14960 diaminohydroxyphosphoribosylaminopyrimidine dehydratase: phosphoglucomutase: reductoisomerase: dehydrogenase: dioxygenase: hppD AAY42_RS05795 AAY42_RS06370 AAY42_RS08300 deaminase/5-amino-6-(5-phosphoribosylamino) AAY42_RS05505 pgmB ilvC AAY42_RS04245 α dCMP -D-ribose- 10 β aldehydo-D- urate urate uracil reductase RibD: ribD an N -formyl- (2-hydroxyphenyl) -D-glucose (R)-2,3-dihydroxy- D-glucopyranose 1-phosphate 5-amino-6-(5-phospho- pyruvate 7,8-dihydrofolate acetate 6-phosphate 3-methylpentanoate glucuronate UTP and CTP dephosphorylation I D-ribitylamino)uracil

UTP D-ribose 5- pyrimidine deoxyribonucleotides phosphate dephosphorylation CTP synthase: nucleoside triphosphate AAY42_RS05925 pyrophosphohydrolase: UDP mazG CTP nucleotide pyrophosphohydrolase: UMP AAY42_RS08135 CDP dCTP dCMP 5'/3'- nucleotidase dUTP diphosphatase: dut SurE: surE CMP [+ 2 isozymes] uridine dUTP dUMP 5'/3'- nucleotidase SurE: surE 5-hydroxy-CTP 5-hydroxy-CMP cytidine

purine deoxyribonucleosides degradation I

2'-deoxyinosine 2'-deoxyadenosine 2'-deoxyguanosine

purine-nucleoside purine-nucleoside purine-nucleoside phosphorylase: phosphorylase: phosphorylase: AAY42_RS14960 AAY42_RS14960 AAY42_RS14960

2-deoxy-α-D- ribose 1-phosphate

a reduced plastocyanin an oxidized plastocyanin ammonium

FeoB RS04320 RS02030 RS05285 NhaC AqpZ RS09350 GltS BrnQ RS08975 RS07535 RS17010 CcoN RS00360 RS09885 RS05770 RS08995 RS14400 RS12855 RS01475 RS12875 CrcB RS11800 Amt RS07000 RS07270

ammonium O 2 H O 2 This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.